Lakić, Mladen

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orcid::0000-0001-7947-1064
  • Lakić, Mladen (6)
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Author's Bibliography

Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite

Lakić, Mladen; Anđelković, Ljubica; Šuljagić, Marija; Vulić, Predrag J.; Perić, Marko; Iskrenović, Predrag; Krstić, Ivan; Kuraica, Milorad M.; Nikolić, Aleksandar S.

(Elsevier, 2019)

TY  - JOUR
AU  - Lakić, Mladen
AU  - Anđelković, Ljubica
AU  - Šuljagić, Marija
AU  - Vulić, Predrag J.
AU  - Perić, Marko
AU  - Iskrenović, Predrag
AU  - Krstić, Ivan
AU  - Kuraica, Milorad M.
AU  - Nikolić, Aleksandar S.
PY  - 2019
AB  - Light-transmitting measurements of white light and a consequentially chosen laser beam of 655 nm propagating through citrate- and oleate-coated CoFe 2 O 4 , FeFe 2 O 4 and MgFe 2 O 4 nanoparticles under the influence of an external magnetic field were presented. New experimental settings were developed for the optical study of ferrites’ behavior in ferrofluid with the applied magnetic field strength within the 30–400 mT range. A magnetic field-induced change of light transmittance occurred and a precipitation of all studied samples was obtained. Optical investigations of ferrofluid suspensions revealed that, contrary to the linear aggregates of colloidal CoFe 2 O 4 and FeFe 2 O 4 , spheroidal aggregates were formed in the case of MgFe 2 O 4 . In all three cases, the surface modification resulted in decreased dipole–dipole interactions between ferrite cores, and thus, less precipitates were noticed. All oleate-coated nanoparticles have demonstrated weaker magnetic responses compared to the citrate-encapsulated samples. The aggregation of nanoparticles potentially increases cytotoxicity. Regarding non-linear clustering of MgFe 2 O 4 suspensions, it can be concluded that its excretion from the organism may likely be easier and faster when used in diagnosis and/or therapy. Therefore, more attention should be paid to the lowly toxic MgFe 2 O 4 regarding its medical application.
PB  - Elsevier
T2  - Optical Materials
T1  - Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite
VL  - 91
SP  - 279
EP  - 285
DO  - 10.1016/j.optmat.2019.03.031
ER  - 
@article{
author = "Lakić, Mladen and Anđelković, Ljubica and Šuljagić, Marija and Vulić, Predrag J. and Perić, Marko and Iskrenović, Predrag and Krstić, Ivan and Kuraica, Milorad M. and Nikolić, Aleksandar S.",
year = "2019",
abstract = "Light-transmitting measurements of white light and a consequentially chosen laser beam of 655 nm propagating through citrate- and oleate-coated CoFe 2 O 4 , FeFe 2 O 4 and MgFe 2 O 4 nanoparticles under the influence of an external magnetic field were presented. New experimental settings were developed for the optical study of ferrites’ behavior in ferrofluid with the applied magnetic field strength within the 30–400 mT range. A magnetic field-induced change of light transmittance occurred and a precipitation of all studied samples was obtained. Optical investigations of ferrofluid suspensions revealed that, contrary to the linear aggregates of colloidal CoFe 2 O 4 and FeFe 2 O 4 , spheroidal aggregates were formed in the case of MgFe 2 O 4 . In all three cases, the surface modification resulted in decreased dipole–dipole interactions between ferrite cores, and thus, less precipitates were noticed. All oleate-coated nanoparticles have demonstrated weaker magnetic responses compared to the citrate-encapsulated samples. The aggregation of nanoparticles potentially increases cytotoxicity. Regarding non-linear clustering of MgFe 2 O 4 suspensions, it can be concluded that its excretion from the organism may likely be easier and faster when used in diagnosis and/or therapy. Therefore, more attention should be paid to the lowly toxic MgFe 2 O 4 regarding its medical application.",
publisher = "Elsevier",
journal = "Optical Materials",
title = "Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite",
volume = "91",
pages = "279-285",
doi = "10.1016/j.optmat.2019.03.031"
}
Lakić, M., Anđelković, L., Šuljagić, M., Vulić, P. J., Perić, M., Iskrenović, P., Krstić, I., Kuraica, M. M.,& Nikolić, A. S.. (2019). Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite. in Optical Materials
Elsevier., 91, 279-285.
https://doi.org/10.1016/j.optmat.2019.03.031
Lakić M, Anđelković L, Šuljagić M, Vulić PJ, Perić M, Iskrenović P, Krstić I, Kuraica MM, Nikolić AS. Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite. in Optical Materials. 2019;91:279-285.
doi:10.1016/j.optmat.2019.03.031 .
Lakić, Mladen, Anđelković, Ljubica, Šuljagić, Marija, Vulić, Predrag J., Perić, Marko, Iskrenović, Predrag, Krstić, Ivan, Kuraica, Milorad M., Nikolić, Aleksandar S., "Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite" in Optical Materials, 91 (2019):279-285,
https://doi.org/10.1016/j.optmat.2019.03.031 . .
6
6
6

A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch

Anđelković, Ljubica; Šuljagić, Marija; Lakić, Mladen; Jeremić, Dejan; Vulić, Predrag J.; Nikolić, Aleksandar S.

(Elsevier Sci Ltd, Oxford, 2018)

TY  - JOUR
AU  - Anđelković, Ljubica
AU  - Šuljagić, Marija
AU  - Lakić, Mladen
AU  - Jeremić, Dejan
AU  - Vulić, Predrag J.
AU  - Nikolić, Aleksandar S.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2171
AB  - Zinc-ferrite, nickel-ferrite and mixed nickel-zinc ferrites were successfully synthesized via the thermal decomposition method from acetylacetonate complexes. To control the particle size and enhance dispersibility in an aqueous medium, starch, a natural and biocompatible compound, was used for the first time for coating such magnetic powders. X-ray powder diffraction (XRPD) was performed to study the structural properties of all samples. The presence of a single-phase spinel structure as well as the cation distribution in both sites of all investigated magnetic powders was confirmed. The values of unit cell parameters obtained from the results of the Rietveld analysis decreased, while the average crystallite size increased with increasing Ni2+ content. The average microstrain parameters unambiguously showed a change in the spinel structure with cation distribution. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) analyses were also utilized to characterize the synthesized materials, corroborating the XRPD data. The obtained results indicated that functionalization by starch was successfully achieved.
PB  - Elsevier Sci Ltd, Oxford
T2  - Ceramics International
T1  - A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch
VL  - 44
IS  - 12
SP  - 14163
EP  - 14168
DO  - 10.1016/j.ceramint.2018.05.018
UR  - Kon_3502
ER  - 
@article{
author = "Anđelković, Ljubica and Šuljagić, Marija and Lakić, Mladen and Jeremić, Dejan and Vulić, Predrag J. and Nikolić, Aleksandar S.",
year = "2018",
abstract = "Zinc-ferrite, nickel-ferrite and mixed nickel-zinc ferrites were successfully synthesized via the thermal decomposition method from acetylacetonate complexes. To control the particle size and enhance dispersibility in an aqueous medium, starch, a natural and biocompatible compound, was used for the first time for coating such magnetic powders. X-ray powder diffraction (XRPD) was performed to study the structural properties of all samples. The presence of a single-phase spinel structure as well as the cation distribution in both sites of all investigated magnetic powders was confirmed. The values of unit cell parameters obtained from the results of the Rietveld analysis decreased, while the average crystallite size increased with increasing Ni2+ content. The average microstrain parameters unambiguously showed a change in the spinel structure with cation distribution. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) analyses were also utilized to characterize the synthesized materials, corroborating the XRPD data. The obtained results indicated that functionalization by starch was successfully achieved.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Ceramics International",
title = "A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch",
volume = "44",
number = "12",
pages = "14163-14168",
doi = "10.1016/j.ceramint.2018.05.018",
url = "Kon_3502"
}
Anđelković, L., Šuljagić, M., Lakić, M., Jeremić, D., Vulić, P. J.,& Nikolić, A. S.. (2018). A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch. in Ceramics International
Elsevier Sci Ltd, Oxford., 44(12), 14163-14168.
https://doi.org/10.1016/j.ceramint.2018.05.018
Kon_3502
Anđelković L, Šuljagić M, Lakić M, Jeremić D, Vulić PJ, Nikolić AS. A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch. in Ceramics International. 2018;44(12):14163-14168.
doi:10.1016/j.ceramint.2018.05.018
Kon_3502 .
Anđelković, Ljubica, Šuljagić, Marija, Lakić, Mladen, Jeremić, Dejan, Vulić, Predrag J., Nikolić, Aleksandar S., "A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch" in Ceramics International, 44, no. 12 (2018):14163-14168,
https://doi.org/10.1016/j.ceramint.2018.05.018 .,
Kon_3502 .
35
33
34

A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch

Anđelković, Ljubica; Šuljagić, Marija; Lakić, Mladen; Jeremić, Dejan; Vulić, Predrag J.; Nikolić, Aleksandar S.

(Elsevier Sci Ltd, Oxford, 2018)

TY  - JOUR
AU  - Anđelković, Ljubica
AU  - Šuljagić, Marija
AU  - Lakić, Mladen
AU  - Jeremić, Dejan
AU  - Vulić, Predrag J.
AU  - Nikolić, Aleksandar S.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3149
AB  - Zinc-ferrite, nickel-ferrite and mixed nickel-zinc ferrites were successfully synthesized via the thermal decomposition method from acetylacetonate complexes. To control the particle size and enhance dispersibility in an aqueous medium, starch, a natural and biocompatible compound, was used for the first time for coating such magnetic powders. X-ray powder diffraction (XRPD) was performed to study the structural properties of all samples. The presence of a single-phase spinel structure as well as the cation distribution in both sites of all investigated magnetic powders was confirmed. The values of unit cell parameters obtained from the results of the Rietveld analysis decreased, while the average crystallite size increased with increasing Ni2+ content. The average microstrain parameters unambiguously showed a change in the spinel structure with cation distribution. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) analyses were also utilized to characterize the synthesized materials, corroborating the XRPD data. The obtained results indicated that functionalization by starch was successfully achieved.
PB  - Elsevier Sci Ltd, Oxford
T2  - Ceramics International
T1  - A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch
VL  - 44
IS  - 12
SP  - 14163
EP  - 14168
DO  - 10.1016/j.ceramint.2018.05.018
UR  - Kon_3502
ER  - 
@article{
author = "Anđelković, Ljubica and Šuljagić, Marija and Lakić, Mladen and Jeremić, Dejan and Vulić, Predrag J. and Nikolić, Aleksandar S.",
year = "2018",
abstract = "Zinc-ferrite, nickel-ferrite and mixed nickel-zinc ferrites were successfully synthesized via the thermal decomposition method from acetylacetonate complexes. To control the particle size and enhance dispersibility in an aqueous medium, starch, a natural and biocompatible compound, was used for the first time for coating such magnetic powders. X-ray powder diffraction (XRPD) was performed to study the structural properties of all samples. The presence of a single-phase spinel structure as well as the cation distribution in both sites of all investigated magnetic powders was confirmed. The values of unit cell parameters obtained from the results of the Rietveld analysis decreased, while the average crystallite size increased with increasing Ni2+ content. The average microstrain parameters unambiguously showed a change in the spinel structure with cation distribution. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) analyses were also utilized to characterize the synthesized materials, corroborating the XRPD data. The obtained results indicated that functionalization by starch was successfully achieved.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Ceramics International",
title = "A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch",
volume = "44",
number = "12",
pages = "14163-14168",
doi = "10.1016/j.ceramint.2018.05.018",
url = "Kon_3502"
}
Anđelković, L., Šuljagić, M., Lakić, M., Jeremić, D., Vulić, P. J.,& Nikolić, A. S.. (2018). A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch. in Ceramics International
Elsevier Sci Ltd, Oxford., 44(12), 14163-14168.
https://doi.org/10.1016/j.ceramint.2018.05.018
Kon_3502
Anđelković L, Šuljagić M, Lakić M, Jeremić D, Vulić PJ, Nikolić AS. A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch. in Ceramics International. 2018;44(12):14163-14168.
doi:10.1016/j.ceramint.2018.05.018
Kon_3502 .
Anđelković, Ljubica, Šuljagić, Marija, Lakić, Mladen, Jeremić, Dejan, Vulić, Predrag J., Nikolić, Aleksandar S., "A study of the structural and morphological properties of Ni-ferrite, Zn-ferrite and Ni-Zn-ferrites functionalized with starch" in Ceramics International, 44, no. 12 (2018):14163-14168,
https://doi.org/10.1016/j.ceramint.2018.05.018 .,
Kon_3502 .
35
33
34

Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone

Lakić, Mladen; Vukadinović, Aleksandar; Kalcher, Kurt; Nikolić, Aleksandar S.; Stanković, Dalibor

(Elsevier Science Bv, Amsterdam, 2016)

TY  - JOUR
AU  - Lakić, Mladen
AU  - Vukadinović, Aleksandar
AU  - Kalcher, Kurt
AU  - Nikolić, Aleksandar S.
AU  - Stanković, Dalibor
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2343
AB  - This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.
PB  - Elsevier Science Bv, Amsterdam
T2  - Talanta
T1  - Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone
VL  - 161
SP  - 668
EP  - 674
DO  - 10.1016/j.talanta.2016.09.029
UR  - Kon_3159
ER  - 
@article{
author = "Lakić, Mladen and Vukadinović, Aleksandar and Kalcher, Kurt and Nikolić, Aleksandar S. and Stanković, Dalibor",
year = "2016",
abstract = "This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Talanta",
title = "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone",
volume = "161",
pages = "668-674",
doi = "10.1016/j.talanta.2016.09.029",
url = "Kon_3159"
}
Lakić, M., Vukadinović, A., Kalcher, K., Nikolić, A. S.,& Stanković, D.. (2016). Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta
Elsevier Science Bv, Amsterdam., 161, 668-674.
https://doi.org/10.1016/j.talanta.2016.09.029
Kon_3159
Lakić M, Vukadinović A, Kalcher K, Nikolić AS, Stanković D. Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta. 2016;161:668-674.
doi:10.1016/j.talanta.2016.09.029
Kon_3159 .
Lakić, Mladen, Vukadinović, Aleksandar, Kalcher, Kurt, Nikolić, Aleksandar S., Stanković, Dalibor, "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone" in Talanta, 161 (2016):668-674,
https://doi.org/10.1016/j.talanta.2016.09.029 .,
Kon_3159 .
18
21
18

Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029

Lakić, Mladen; Vukadinović, Aleksandar; Kalcher, Kurt; Nikolić, Aleksandar S.; Stanković, Dalibor

(Elsevier Science Bv, Amsterdam, 2016)

TY  - DATA
AU  - Lakić, Mladen
AU  - Vukadinović, Aleksandar
AU  - Kalcher, Kurt
AU  - Nikolić, Aleksandar S.
AU  - Stanković, Dalibor
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3507
PB  - Elsevier Science Bv, Amsterdam
T2  - Talanta
T1  - Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029
ER  - 
@misc{
author = "Lakić, Mladen and Vukadinović, Aleksandar and Kalcher, Kurt and Nikolić, Aleksandar S. and Stanković, Dalibor",
year = "2016",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Talanta",
title = "Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029"
}
Lakić, M., Vukadinović, A., Kalcher, K., Nikolić, A. S.,& Stanković, D.. (2016). Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029. in Talanta
Elsevier Science Bv, Amsterdam..
Lakić M, Vukadinović A, Kalcher K, Nikolić AS, Stanković D. Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029. in Talanta. 2016;..
Lakić, Mladen, Vukadinović, Aleksandar, Kalcher, Kurt, Nikolić, Aleksandar S., Stanković, Dalibor, "Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029" in Talanta (2016).

Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent

Lakić, Mladen; Sabo, Ljubica; Ristić, Slavica; Savić, Aleksandar; Petričević, Saša; Nikolić, Nadežda; Vukadinović, Aleksandar; Janković, Drina; Sabo, Tibor; Vranješ-Đuric, Sanja

(Wiley, Hoboken, 2016)

TY  - JOUR
AU  - Lakić, Mladen
AU  - Sabo, Ljubica
AU  - Ristić, Slavica
AU  - Savić, Aleksandar
AU  - Petričević, Saša
AU  - Nikolić, Nadežda
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Sabo, Tibor
AU  - Vranješ-Đuric, Sanja
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2045
AB  - The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O'-diethylethylenediamine-N,N'-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L') and diacid ligand (L"), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m'(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley & Sons, Ltd.
PB  - Wiley, Hoboken
T2  - Applied Organometallic Chemistry
T1  - Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent
VL  - 30
IS  - 2
SP  - 81
EP  - 88
DO  - 10.1002/aoc.3401
UR  - Kon_3001
ER  - 
@article{
author = "Lakić, Mladen and Sabo, Ljubica and Ristić, Slavica and Savić, Aleksandar and Petričević, Saša and Nikolić, Nadežda and Vukadinović, Aleksandar and Janković, Drina and Sabo, Tibor and Vranješ-Đuric, Sanja",
year = "2016",
abstract = "The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O'-diethylethylenediamine-N,N'-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L') and diacid ligand (L"), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m'(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley & Sons, Ltd.",
publisher = "Wiley, Hoboken",
journal = "Applied Organometallic Chemistry",
title = "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent",
volume = "30",
number = "2",
pages = "81-88",
doi = "10.1002/aoc.3401",
url = "Kon_3001"
}
Lakić, M., Sabo, L., Ristić, S., Savić, A., Petričević, S., Nikolić, N., Vukadinović, A., Janković, D., Sabo, T.,& Vranješ-Đuric, S.. (2016). Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry
Wiley, Hoboken., 30(2), 81-88.
https://doi.org/10.1002/aoc.3401
Kon_3001
Lakić M, Sabo L, Ristić S, Savić A, Petričević S, Nikolić N, Vukadinović A, Janković D, Sabo T, Vranješ-Đuric S. Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry. 2016;30(2):81-88.
doi:10.1002/aoc.3401
Kon_3001 .
Lakić, Mladen, Sabo, Ljubica, Ristić, Slavica, Savić, Aleksandar, Petričević, Saša, Nikolić, Nadežda, Vukadinović, Aleksandar, Janković, Drina, Sabo, Tibor, Vranješ-Đuric, Sanja, "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent" in Applied Organometallic Chemistry, 30, no. 2 (2016):81-88,
https://doi.org/10.1002/aoc.3401 .,
Kon_3001 .
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