TY  - JOUR
AU  - Lolić, Aleksandar
AU  - Paiga, Paula
AU  - Santos, Lucia H. M. L. M.
AU  - Ramos, Sandra
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1653
AB  - The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L-1, respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L-1). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and September. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment.
PB  - Elsevier Science Bv, Amsterdam
T2  - Science of the Total Environment
T1  - Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk
VL  - 508
SP  - 240
EP  - 250
DO  - 10.1016/j.scitotenv.2014.11.097
ER  - 

@article{
author = "Lolić, Aleksandar and Paiga, Paula and Santos, Lucia H. M. L. M. and Ramos, Sandra and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
abstract = "The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L-1, respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L-1). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and September. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Science of the Total Environment",
title = "Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk",
volume = "508",
pages = "240-250",
doi = "10.1016/j.scitotenv.2014.11.097"
}

Lolić, A., Paiga, P., Santos, L. H. M. L. M., Ramos, S., Correia, M.,& Delerue-Matos, C.. (2015). Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk. in Science of the Total Environment
Elsevier Science Bv, Amsterdam., 508, 240-250.
https://doi.org/10.1016/j.scitotenv.2014.11.097

Lolić A, Paiga P, Santos LHMLM, Ramos S, Correia M, Delerue-Matos C. Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk. in Science of the Total Environment. 2015;508:240-250.
doi:10.1016/j.scitotenv.2014.11.097 .

Lolić, Aleksandar, Paiga, Paula, Santos, Lucia H. M. L. M., Ramos, Sandra, Correia, Manuela, Delerue-Matos, Cristina, "Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk" in Science of the Total Environment, 508 (2015):240-250,
https://doi.org/10.1016/j.scitotenv.2014.11.097 . .

TY  - JOUR
AU  - Paiga, Paula
AU  - Lolić, Aleksandar
AU  - Hellebuyck, Floris
AU  - Santos, Lucia H. M. L. M.
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1674
AB  - An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater
VL  - 106
SP  - 61
EP  - 70
DO  - 10.1016/j.jpba.2014.06.017
ER  - 

@article{
author = "Paiga, Paula and Lolić, Aleksandar and Hellebuyck, Floris and Santos, Lucia H. M. L. M. and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
abstract = "An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater",
volume = "106",
pages = "61-70",
doi = "10.1016/j.jpba.2014.06.017"
}

Paiga, P., Lolić, A., Hellebuyck, F., Santos, L. H. M. L. M., Correia, M.,& Delerue-Matos, C.. (2015). Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam., 106, 61-70.
https://doi.org/10.1016/j.jpba.2014.06.017

Paiga P, Lolić A, Hellebuyck F, Santos LHMLM, Correia M, Delerue-Matos C. Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis. 2015;106:61-70.
doi:10.1016/j.jpba.2014.06.017 .

Paiga, Paula, Lolić, Aleksandar, Hellebuyck, Floris, Santos, Lucia H. M. L. M., Correia, Manuela, Delerue-Matos, Cristina, "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater" in Journal of Pharmaceutical and Biomedical Analysis, 106 (2015):61-70,
https://doi.org/10.1016/j.jpba.2014.06.017 . .

TY  - DATA
AU  - Lolić, Aleksandar
AU  - Paiga, Paula
AU  - Santos, Lucia H. M. L. M.
AU  - Ramos, Sandra
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3340
PB  - Elsevier Science Bv, Amsterdam
T2  - Science of the Total Environment
T1  - Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3340
ER  - 

@misc{
author = "Lolić, Aleksandar and Paiga, Paula and Santos, Lucia H. M. L. M. and Ramos, Sandra and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Science of the Total Environment",
title = "Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3340"
}

Lolić, A., Paiga, P., Santos, L. H. M. L. M., Ramos, S., Correia, M.,& Delerue-Matos, C.. (2015). Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097. in Science of the Total Environment
Elsevier Science Bv, Amsterdam..
https://hdl.handle.net/21.15107/rcub_cherry_3340

Lolić A, Paiga P, Santos LHMLM, Ramos S, Correia M, Delerue-Matos C. Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097. in Science of the Total Environment. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3340 .

Lolić, Aleksandar, Paiga, Paula, Santos, Lucia H. M. L. M., Ramos, Sandra, Correia, Manuela, Delerue-Matos, Cristina, "Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097" in Science of the Total Environment (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3340 .

TY  - DATA
AU  - Paiga, Paula
AU  - Lolić, Aleksandar
AU  - Hellebuyck, Floris
AU  - Santos, Lucia H. M. L. M.
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3362
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3362
ER  - 

@misc{
author = "Paiga, Paula and Lolić, Aleksandar and Hellebuyck, Floris and Santos, Lucia H. M. L. M. and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3362"
}

Paiga, P., Lolić, A., Hellebuyck, F., Santos, L. H. M. L. M., Correia, M.,& Delerue-Matos, C.. (2015). Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam..
https://hdl.handle.net/21.15107/rcub_cherry_3362

Paiga P, Lolić A, Hellebuyck F, Santos LHMLM, Correia M, Delerue-Matos C. Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017. in Journal of Pharmaceutical and Biomedical Analysis. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3362 .

Paiga, Paula, Lolić, Aleksandar, Hellebuyck, Floris, Santos, Lucia H. M. L. M., Correia, Manuela, Delerue-Matos, Cristina, "Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017" in Journal of Pharmaceutical and Biomedical Analysis (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3362 .