TY  - JOUR
AU  - Borković-Mitić, Slavica S.
AU  - Stojsavljević, Aleksandar
AU  - Vjotić, Ljiljana
AU  - Matić, Siniša
AU  - Mitić, Bojan M.
AU  - Manojlović, Dragan D.
AU  - Pavlović, Slađan Z.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4820
AB  - There are only a few reports examining the impact of oxidative stress in patients with benign andmalignant brain tumors. In this study we investigated whether there are changes in antioxidantsystem (AOS) parameters and key trace elements between control, benign and malignant braintissues. The study also aimed to examine correlations between the analyzed parameters. The studyenrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The resultswere compared with control tissue (CT) without tumor infiltration collected from patients with BT.The following antioxidant parameters were determined: activities of total, manganese‑containing,and copper/zinc‑containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities ofcatalase, glutathione peroxidase, glutathione S‑transferase, glutathione reductase and acetylcholineesterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn),copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOSparameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changesin AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and highGST activities were significant for distinguishing between MT and CT. Malignant tissue was alsocharacterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysisclearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BTand MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in theMT group. The results of this study reveal differences between the AOS parameters and the essentialtrace elements between the analyzed groups. The observed dysregulations show that oxidative stresscould have an important role in disrupting brain homeostasis and its presence in the pathogenesis ofbenign and malignant brain tumors.
PB  - Springer
T2  - Scientifc Reports
T1  - Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues
VL  - 11
SP  - 14776
DO  - 10.1038/s41598-021-94302-5
ER  - 

@article{
author = "Borković-Mitić, Slavica S. and Stojsavljević, Aleksandar and Vjotić, Ljiljana and Matić, Siniša and Mitić, Bojan M. and Manojlović, Dragan D. and Pavlović, Slađan Z.",
year = "2021",
abstract = "There are only a few reports examining the impact of oxidative stress in patients with benign andmalignant brain tumors. In this study we investigated whether there are changes in antioxidantsystem (AOS) parameters and key trace elements between control, benign and malignant braintissues. The study also aimed to examine correlations between the analyzed parameters. The studyenrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The resultswere compared with control tissue (CT) without tumor infiltration collected from patients with BT.The following antioxidant parameters were determined: activities of total, manganese‑containing,and copper/zinc‑containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities ofcatalase, glutathione peroxidase, glutathione S‑transferase, glutathione reductase and acetylcholineesterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn),copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOSparameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changesin AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and highGST activities were significant for distinguishing between MT and CT. Malignant tissue was alsocharacterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysisclearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BTand MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in theMT group. The results of this study reveal differences between the AOS parameters and the essentialtrace elements between the analyzed groups. The observed dysregulations show that oxidative stresscould have an important role in disrupting brain homeostasis and its presence in the pathogenesis ofbenign and malignant brain tumors.",
publisher = "Springer",
journal = "Scientifc Reports",
title = "Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues",
volume = "11",
pages = "14776",
doi = "10.1038/s41598-021-94302-5"
}

Borković-Mitić, S. S., Stojsavljević, A., Vjotić, L., Matić, S., Mitić, B. M., Manojlović, D. D.,& Pavlović, S. Z.. (2021). Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. in Scientifc Reports
Springer., 11, 14776.
https://doi.org/10.1038/s41598-021-94302-5

Borković-Mitić SS, Stojsavljević A, Vjotić L, Matić S, Mitić BM, Manojlović DD, Pavlović SZ. Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. in Scientifc Reports. 2021;11:14776.
doi:10.1038/s41598-021-94302-5 .

Borković-Mitić, Slavica S., Stojsavljević, Aleksandar, Vjotić, Ljiljana, Matić, Siniša, Mitić, Bojan M., Manojlović, Dragan D., Pavlović, Slađan Z., "Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues" in Scientifc Reports, 11 (2021):14776,
https://doi.org/10.1038/s41598-021-94302-5 . .

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković-Mitić, Slavica S.
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan Z.
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3982
AB  - Introduction: Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus. Material and methods: Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe. Results: The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor. Conclusions: There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia Publishing House
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
VL  - 16
IS  - 4
SP  - 811
EP  - 819
DO  - 10.5114/aoms.2019.87409
ER  - 

@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković-Mitić, Slavica S. and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan Z.",
year = "2020",
abstract = "Introduction: Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus. Material and methods: Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe. Results: The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor. Conclusions: There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia Publishing House",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
volume = "16",
number = "4",
pages = "811-819",
doi = "10.5114/aoms.2019.87409"
}

Vujotić, L., Matić, S., Borković-Mitić, S. S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S. Z.. (2020). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science
Termedia Publishing House., 16(4), 811-819.
https://doi.org/10.5114/aoms.2019.87409

Vujotić L, Matić S, Borković-Mitić SS, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović SZ. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. in Archives of Medical Science. 2020;16(4):811-819.
doi:10.5114/aoms.2019.87409 .

Vujotić, Ljiljana, Matić, Siniša, Borković-Mitić, Slavica S., Stojsavljević, Aleksandar, Mutić, Jelena, Baščarević, Vladimir, Joković, Miloš, Pavlović, Slađan Z., "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" in Archives of Medical Science, 16, no. 4 (2020):811-819,
https://doi.org/10.5114/aoms.2019.87409 . .