TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna
AU  - Tešević, Vele
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2446
AB  - The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V.
PB  - Elsevier Science Bv, Amsterdam
T2  - Arabian Journal of Chemistry
T1  - Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells
VL  - 10
SP  - 1240
EP  - 1242
DO  - 10.1016/j.arabjc.2013.03.003
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Bogdanović, Gordana and Kojić, Vesna and Tešević, Vele",
year = "2017",
abstract = "The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Arabian Journal of Chemistry",
title = "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells",
volume = "10",
pages = "1240-1242",
doi = "10.1016/j.arabjc.2013.03.003"
}

Pejin, B., Iodice, C., Bogdanović, G., Kojić, V.,& Tešević, V.. (2017). Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry
Elsevier Science Bv, Amsterdam., 10, 1240-1242.
https://doi.org/10.1016/j.arabjc.2013.03.003

Pejin B, Iodice C, Bogdanović G, Kojić V, Tešević V. Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry. 2017;10:1240-1242.
doi:10.1016/j.arabjc.2013.03.003 .

Pejin, Boris, Iodice, Carmine, Bogdanović, Gordana, Kojić, Vesna, Tešević, Vele, "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells" in Arabian Journal of Chemistry, 10 (2017):1240-1242,
https://doi.org/10.1016/j.arabjc.2013.03.003 . .

TY  - JOUR
AU  - Joksović, Milan D.
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna
AU  - Szecsenyi, Katalin Meszaros
AU  - Leovac, Vukadin M.
AU  - Jakimov, Dimitar
AU  - Trifunović, Snežana S.
AU  - Marković, Violeta
AU  - Joksović, Ljubinka
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1097
AB  - New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Heterocyclic Chemistry
T1  - Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids
VL  - 47
IS  - 4
SP  - 850
EP  - 856
DO  - 10.1002/jhet.400
ER  - 

@article{
author = "Joksović, Milan D. and Bogdanović, Gordana and Kojić, Vesna and Szecsenyi, Katalin Meszaros and Leovac, Vukadin M. and Jakimov, Dimitar and Trifunović, Snežana S. and Marković, Violeta and Joksović, Ljubinka",
year = "2010",
abstract = "New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Heterocyclic Chemistry",
title = "Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids",
volume = "47",
number = "4",
pages = "850-856",
doi = "10.1002/jhet.400"
}

Joksović, M. D., Bogdanović, G., Kojić, V., Szecsenyi, K. M., Leovac, V. M., Jakimov, D., Trifunović, S. S., Marković, V.,& Joksović, L.. (2010). Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids. in Journal of Heterocyclic Chemistry
Wiley-Blackwell, Malden., 47(4), 850-856.
https://doi.org/10.1002/jhet.400

Joksović MD, Bogdanović G, Kojić V, Szecsenyi KM, Leovac VM, Jakimov D, Trifunović SS, Marković V, Joksović L. Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids. in Journal of Heterocyclic Chemistry. 2010;47(4):850-856.
doi:10.1002/jhet.400 .

Joksović, Milan D., Bogdanović, Gordana, Kojić, Vesna, Szecsenyi, Katalin Meszaros, Leovac, Vukadin M., Jakimov, Dimitar, Trifunović, Snežana S., Marković, Violeta, Joksović, Ljubinka, "Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids" in Journal of Heterocyclic Chemistry, 47, no. 4 (2010):850-856,
https://doi.org/10.1002/jhet.400 . .