Filipović, Dragana

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orcid::0000-0002-7828-4168
  • Filipović, Dragana (4)
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Author's Bibliography

Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study

Filipović, Dragana; Gašić, Uroš M.; Stevanović, Nikola R.; Dabić-Zagorac, Dragana; Fotirić-Akšić, Milica M.; Natić, Maja

(Taylor & Francis Ltd, Abingdon, 2018)

TY  - JOUR
AU  - Filipović, Dragana
AU  - Gašić, Uroš M.
AU  - Stevanović, Nikola R.
AU  - Dabić-Zagorac, Dragana
AU  - Fotirić-Akšić, Milica M.
AU  - Natić, Maja
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2160
AB  - The carbon stable isotope content of Cornelian cherry stones collected from wild tree stands in Serbia, SE Europe, was measured using elemental analyser-isotope ratio mass spectrometry, with the aim of recording natural carbon isotope composition of the fruit stones and its possible variation. The results show a significant variation in the carbon isotope values; we identified several environmental factors that, along with a number of other possible determinants, likely contributed to this variation. The obtained data are compared with the measurement of carbon isotope content of an archaeological specimen of Cornelian cherry stone discovered at the Neolithic site of Vina (ca. 5600-4500 BC) in Serbia. Notwithstanding the limitedness of the data and the complexity surrounding carbon fractionation and the isotopic variation, it is suggested that the differences/similarities in carbon isotope ratios between modern and archaeological Cornelian cherry stones, when measured for much larger assemblages, could potentially offer a glimpse into growing conditions of Cornelian cherry trees in the past.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Isotopes in Environmental and Health Studies
T1  - Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study
VL  - 54
IS  - 4
SP  - 337
EP  - 351
DO  - 10.1080/10256016.2017.1392516
ER  - 
@article{
author = "Filipović, Dragana and Gašić, Uroš M. and Stevanović, Nikola R. and Dabić-Zagorac, Dragana and Fotirić-Akšić, Milica M. and Natić, Maja",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2160",
abstract = "The carbon stable isotope content of Cornelian cherry stones collected from wild tree stands in Serbia, SE Europe, was measured using elemental analyser-isotope ratio mass spectrometry, with the aim of recording natural carbon isotope composition of the fruit stones and its possible variation. The results show a significant variation in the carbon isotope values; we identified several environmental factors that, along with a number of other possible determinants, likely contributed to this variation. The obtained data are compared with the measurement of carbon isotope content of an archaeological specimen of Cornelian cherry stone discovered at the Neolithic site of Vina (ca. 5600-4500 BC) in Serbia. Notwithstanding the limitedness of the data and the complexity surrounding carbon fractionation and the isotopic variation, it is suggested that the differences/similarities in carbon isotope ratios between modern and archaeological Cornelian cherry stones, when measured for much larger assemblages, could potentially offer a glimpse into growing conditions of Cornelian cherry trees in the past.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Isotopes in Environmental and Health Studies",
title = "Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study",
volume = "54",
number = "4",
pages = "337-351",
doi = "10.1080/10256016.2017.1392516"
}
Filipović, D., Gašić, U. M., Stevanović, N. R., Dabić-Zagorac, D., Fotirić-Akšić, M. M.,& Natić, M. (2018). Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study.
Isotopes in Environmental and Health Studies
Taylor & Francis Ltd, Abingdon., 54(4), 337-351.
https://doi.org/10.1080/10256016.2017.1392516
Filipović D, Gašić UM, Stevanović NR, Dabić-Zagorac D, Fotirić-Akšić MM, Natić M. Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study. Isotopes in Environmental and Health Studies. 2018;54(4):337-351
Filipović Dragana, Gašić Uroš M., Stevanović Nikola R., Dabić-Zagorac Dragana, Fotirić-Akšić Milica M., Natić Maja, "Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study" Isotopes in Environmental and Health Studies, 54, no. 4 (2018):337-351,
https://doi.org/10.1080/10256016.2017.1392516 .
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Chronic isolation stress compromises JNK/c-Jun signaling in rat brain

Filipović, Dragana; Zlatkovic, Jelena; Pavićević, Ivan D.; Mandić, Ljuba M.; Demajo, Miroslav

(Springer Wien, Wien, 2012)

TY  - JOUR
AU  - Filipović, Dragana
AU  - Zlatkovic, Jelena
AU  - Pavićević, Ivan D.
AU  - Mandić, Ljuba M.
AU  - Demajo, Miroslav
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1540
AB  - The c-Jun NH2-terminal kinases (JNKs) are important stress-responsive kinases. They regulate cellular activities by sequential phosphorylation and activation through a mitogen-activated protein kinase cascade, whereas JNKs activation is altered in response to various stressors. In the present study, we used immunoblotting to assess the effect of 21 day of social isolation as the chronic stressor, either sole and in combination with 2 h of acute immobilization or cold (4A degrees C) stress on circulating corticosterone level and phosphorylation status of p46 (phospho-p46/total p46) and p54 (phospho-p54/total p54) JNK isoforms in the cytosolic and nuclear fraction of the prefrontal cortex and hippocampus of male Wistar rats. Also, the phosphorylation status of JNK nuclear down-stream target c-Jun (p-c-Jun/c-Jun) on Ser63 was examined. Both acute stressors with elevated CORT levels led to increased phosphorylation status of cytosolic p54 JNK isoforms but not p46 JNK isoforms only in the hippocampus and no change in phosphorylation status of c-jun in both brain regions. Chronic isolation with unaltered CORT level and reduced responsiveness to novel acute stressors, led to unchanged or reduced phosphorylation status of p46 and p54 JNK isoforms in both fractions and both brain regions, whereas the decrease of c-Jun phosphorylation status was found only in the prefrontal cortex. Our results suggest that compromised JNKs activation following chronic isolation may lead to interruption of JNK signaling, which could be related with neuropsychiatric disorders such as depression or long-lasting neuronal remodeling.
PB  - Springer Wien, Wien
T2  - Journal of Neural Transmission
T1  - Chronic isolation stress compromises JNK/c-Jun signaling in rat brain
VL  - 119
IS  - 11
SP  - 1275
EP  - 1284
DO  - 10.1007/s00702-012-0776-0
ER  - 
@article{
author = "Filipović, Dragana and Zlatkovic, Jelena and Pavićević, Ivan D. and Mandić, Ljuba M. and Demajo, Miroslav",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1540",
abstract = "The c-Jun NH2-terminal kinases (JNKs) are important stress-responsive kinases. They regulate cellular activities by sequential phosphorylation and activation through a mitogen-activated protein kinase cascade, whereas JNKs activation is altered in response to various stressors. In the present study, we used immunoblotting to assess the effect of 21 day of social isolation as the chronic stressor, either sole and in combination with 2 h of acute immobilization or cold (4A degrees C) stress on circulating corticosterone level and phosphorylation status of p46 (phospho-p46/total p46) and p54 (phospho-p54/total p54) JNK isoforms in the cytosolic and nuclear fraction of the prefrontal cortex and hippocampus of male Wistar rats. Also, the phosphorylation status of JNK nuclear down-stream target c-Jun (p-c-Jun/c-Jun) on Ser63 was examined. Both acute stressors with elevated CORT levels led to increased phosphorylation status of cytosolic p54 JNK isoforms but not p46 JNK isoforms only in the hippocampus and no change in phosphorylation status of c-jun in both brain regions. Chronic isolation with unaltered CORT level and reduced responsiveness to novel acute stressors, led to unchanged or reduced phosphorylation status of p46 and p54 JNK isoforms in both fractions and both brain regions, whereas the decrease of c-Jun phosphorylation status was found only in the prefrontal cortex. Our results suggest that compromised JNKs activation following chronic isolation may lead to interruption of JNK signaling, which could be related with neuropsychiatric disorders such as depression or long-lasting neuronal remodeling.",
publisher = "Springer Wien, Wien",
journal = "Journal of Neural Transmission",
title = "Chronic isolation stress compromises JNK/c-Jun signaling in rat brain",
volume = "119",
number = "11",
pages = "1275-1284",
doi = "10.1007/s00702-012-0776-0"
}
Filipović, D., Zlatkovic, J., Pavićević, I. D., Mandić, L. M.,& Demajo, M. (2012). Chronic isolation stress compromises JNK/c-Jun signaling in rat brain.
Journal of Neural Transmission
Springer Wien, Wien., 119(11), 1275-1284.
https://doi.org/10.1007/s00702-012-0776-0
Filipović D, Zlatkovic J, Pavićević ID, Mandić LM, Demajo M. Chronic isolation stress compromises JNK/c-Jun signaling in rat brain. Journal of Neural Transmission. 2012;119(11):1275-1284
Filipović Dragana, Zlatkovic Jelena, Pavićević Ivan D., Mandić Ljuba M., Demajo Miroslav, "Chronic isolation stress compromises JNK/c-Jun signaling in rat brain" Journal of Neural Transmission, 119, no. 11 (2012):1275-1284,
https://doi.org/10.1007/s00702-012-0776-0 .
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Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver

Filipović, Dragana; Mandić, Ljuba M.; Kanazir, Dusan; Pajović, Snezana B.

(Springer, Dordrecht, 2010)

TY  - JOUR
AU  - Filipović, Dragana
AU  - Mandić, Ljuba M.
AU  - Kanazir, Dusan
AU  - Pajović, Snezana B.
PY  - 2010
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1072
AB  - Cellular protection against oxidative stress is afforded by the enzyme superoxide dismutase (SOD). In this study, the protein levels of copper-zinc SOD (CuZnSOD) in the cytosolic and nuclear fraction, manganese SOD (MnSOD) in the mitochondrial, and cytosolic fraction and cytochrome c (cyt c) in the liver of male rats exposed to 2 h of acute immobilization (IM) or Cold stress, 21 days chronic isolation or their combinations (chronic/acute stress) were examined. The serum corticosterone (CORT) level was measured, as an indicator of stress stimuli. Both acute stressors with elevated CORT levels caused a decrease of mitochondrial MnSOD, while acute IM resulted in redistribution of the CuZnSOD protein level between the cytosolic and nuclear fraction. Chronic isolation, during which the CORT level was close to control value, resulted in an increase of cytosolic CuZnSOD, whereas a decrease of MnSOD in mitochondrial and its corresponding increase in cytosol fraction was found. In both combined stress regimes, an increase of the CuZnSOD and MnSOD levels in the cytosolic fraction was recorded whereby increase of the CORT level was observed only in the chronic isolation followed by acute IM. The data indicate that acute and/or chronic stress models have different degrees of influence on serum CORT and SOD subcellular protein levels. Increased cytosolic CuZnSOD protein level under chronic isolation suggests that state of oxidative stress may also exist under CORT level similar to the basal value. The presence of MnSOD and cyt c in the cytosolic fraction could serve as useful parameters for mitochondrial dysfunction.
PB  - Springer, Dordrecht
T2  - Molecular and Cellular Biochemistry
T1  - Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver
VL  - 338
IS  - 1-2
SP  - 167
EP  - 174
DO  - 10.1007/s11010-009-0350-8
ER  - 
@article{
author = "Filipović, Dragana and Mandić, Ljuba M. and Kanazir, Dusan and Pajović, Snezana B.",
year = "2010",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1072",
abstract = "Cellular protection against oxidative stress is afforded by the enzyme superoxide dismutase (SOD). In this study, the protein levels of copper-zinc SOD (CuZnSOD) in the cytosolic and nuclear fraction, manganese SOD (MnSOD) in the mitochondrial, and cytosolic fraction and cytochrome c (cyt c) in the liver of male rats exposed to 2 h of acute immobilization (IM) or Cold stress, 21 days chronic isolation or their combinations (chronic/acute stress) were examined. The serum corticosterone (CORT) level was measured, as an indicator of stress stimuli. Both acute stressors with elevated CORT levels caused a decrease of mitochondrial MnSOD, while acute IM resulted in redistribution of the CuZnSOD protein level between the cytosolic and nuclear fraction. Chronic isolation, during which the CORT level was close to control value, resulted in an increase of cytosolic CuZnSOD, whereas a decrease of MnSOD in mitochondrial and its corresponding increase in cytosol fraction was found. In both combined stress regimes, an increase of the CuZnSOD and MnSOD levels in the cytosolic fraction was recorded whereby increase of the CORT level was observed only in the chronic isolation followed by acute IM. The data indicate that acute and/or chronic stress models have different degrees of influence on serum CORT and SOD subcellular protein levels. Increased cytosolic CuZnSOD protein level under chronic isolation suggests that state of oxidative stress may also exist under CORT level similar to the basal value. The presence of MnSOD and cyt c in the cytosolic fraction could serve as useful parameters for mitochondrial dysfunction.",
publisher = "Springer, Dordrecht",
journal = "Molecular and Cellular Biochemistry",
title = "Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver",
volume = "338",
number = "1-2",
pages = "167-174",
doi = "10.1007/s11010-009-0350-8"
}
Filipović, D., Mandić, L. M., Kanazir, D.,& Pajović, S. B. (2010). Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver.
Molecular and Cellular Biochemistry
Springer, Dordrecht., 338(1-2), 167-174.
https://doi.org/10.1007/s11010-009-0350-8
Filipović D, Mandić LM, Kanazir D, Pajović SB. Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver. Molecular and Cellular Biochemistry. 2010;338(1-2):167-174
Filipović Dragana, Mandić Ljuba M., Kanazir Dusan, Pajović Snezana B., "Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver" Molecular and Cellular Biochemistry, 338, no. 1-2 (2010):167-174,
https://doi.org/10.1007/s11010-009-0350-8 .
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Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes

Mandić, Ljuba M.; Filipović, Dragana

(Academic Press Aust, Marrickville, 1998)

TY  - JOUR
AU  - Mandić, Ljuba M.
AU  - Filipović, Dragana
PY  - 1998
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/382
AB  - The activity of the isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) is determined in the serum of insulin-dependent (IDDM) and non insulin-dependent diabetics (NIDDM) with or without diabetic complications. The increase in total activity of serum NAG in diabetics is proportional to the A form activity (r=0,976, p lt  0,0001). The contribution of the A form activity (65.87+/-5.99%) to total NAG activity of IDDM and NIDDM diabetics with and without complications does not change considerably compared to the control group. The contribution of the B form activity depends on the state of metabolic monitoring and diabetic complications. A significantly lower activity of the serum B form was found in IDDM (p lt 0,001) and NIDDM diabetics (p lt 0,05) compared to the healthy individuals, as well as the higher activity ratios of the A/B forms. A decrease in serum B form is correlated with the occurrence and abundance of the intermediary I forms (r=-0,665). These changes are particularly significant in the individuals with the pronounced microangiopathy.
PB  - Academic Press Aust, Marrickville
T2  - Biochemistry and Molecular Biology International
T1  - Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes
VL  - 45
IS  - 3
SP  - 545
EP  - 554
ER  - 
@article{
author = "Mandić, Ljuba M. and Filipović, Dragana",
year = "1998",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/382",
abstract = "The activity of the isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) is determined in the serum of insulin-dependent (IDDM) and non insulin-dependent diabetics (NIDDM) with or without diabetic complications. The increase in total activity of serum NAG in diabetics is proportional to the A form activity (r=0,976, p lt  0,0001). The contribution of the A form activity (65.87+/-5.99%) to total NAG activity of IDDM and NIDDM diabetics with and without complications does not change considerably compared to the control group. The contribution of the B form activity depends on the state of metabolic monitoring and diabetic complications. A significantly lower activity of the serum B form was found in IDDM (p lt 0,001) and NIDDM diabetics (p lt 0,05) compared to the healthy individuals, as well as the higher activity ratios of the A/B forms. A decrease in serum B form is correlated with the occurrence and abundance of the intermediary I forms (r=-0,665). These changes are particularly significant in the individuals with the pronounced microangiopathy.",
publisher = "Academic Press Aust, Marrickville",
journal = "Biochemistry and Molecular Biology International",
title = "Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes",
volume = "45",
number = "3",
pages = "545-554"
}
Mandić, L. M.,& Filipović, D. (1998). Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes.
Biochemistry and Molecular Biology International
Academic Press Aust, Marrickville., 45(3), 545-554.
Mandić LM, Filipović D. Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes. Biochemistry and Molecular Biology International. 1998;45(3):545-554
Mandić Ljuba M., Filipović Dragana, "Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes" Biochemistry and Molecular Biology International, 45, no. 3 (1998):545-554
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