TY  - JOUR
AU  - Borges, Anabela
AU  - Simoes, Manuel
AU  - Todorović, Tamara
AU  - Filipović, Nenad R.
AU  - Garcia-Sosa, Alfonso T.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2163
AB  - Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.
PB  - Mdpi, Basel
T2  - Molecules
T1  - Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator
VL  - 23
IS  - 6
DO  - 10.3390/molecules23061385
ER  - 

@article{
author = "Borges, Anabela and Simoes, Manuel and Todorović, Tamara and Filipović, Nenad R. and Garcia-Sosa, Alfonso T.",
year = "2018",
abstract = "Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.",
publisher = "Mdpi, Basel",
journal = "Molecules",
title = "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator",
volume = "23",
number = "6",
doi = "10.3390/molecules23061385"
}

Borges, A., Simoes, M., Todorović, T., Filipović, N. R.,& Garcia-Sosa, A. T.. (2018). Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules
Mdpi, Basel., 23(6).
https://doi.org/10.3390/molecules23061385

Borges A, Simoes M, Todorović T, Filipović NR, Garcia-Sosa AT. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules. 2018;23(6).
doi:10.3390/molecules23061385 .

Borges, Anabela, Simoes, Manuel, Todorović, Tamara, Filipović, Nenad R., Garcia-Sosa, Alfonso T., "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator" in Molecules, 23, no. 6 (2018),
https://doi.org/10.3390/molecules23061385 . .

TY  - DATA
AU  - Borges, Anabela
AU  - Simoes, Manuel
AU  - Todorović, Tamara
AU  - Filipović, Nenad R.
AU  - Garcia-Sosa, Alfonso T.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3141
PB  - Mdpi, Basel
T2  - Molecules
T1  - Supplementary data for the article: Borges, A.; Simões, M.; Todorović, T. R.; Filipović, N. R.; Garcia-Sosa, A. T. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas Aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. Molecules 2018, 23 (6). https://doi.org/10.3390/molecules23061385
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3141
ER  - 

@misc{
author = "Borges, Anabela and Simoes, Manuel and Todorović, Tamara and Filipović, Nenad R. and Garcia-Sosa, Alfonso T.",
year = "2018",
publisher = "Mdpi, Basel",
journal = "Molecules",
title = "Supplementary data for the article: Borges, A.; Simões, M.; Todorović, T. R.; Filipović, N. R.; Garcia-Sosa, A. T. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas Aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. Molecules 2018, 23 (6). https://doi.org/10.3390/molecules23061385",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3141"
}

Borges, A., Simoes, M., Todorović, T., Filipović, N. R.,& Garcia-Sosa, A. T.. (2018). Supplementary data for the article: Borges, A.; Simões, M.; Todorović, T. R.; Filipović, N. R.; Garcia-Sosa, A. T. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas Aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. Molecules 2018, 23 (6). https://doi.org/10.3390/molecules23061385. in Molecules
Mdpi, Basel..
https://hdl.handle.net/21.15107/rcub_cherry_3141

Borges A, Simoes M, Todorović T, Filipović NR, Garcia-Sosa AT. Supplementary data for the article: Borges, A.; Simões, M.; Todorović, T. R.; Filipović, N. R.; Garcia-Sosa, A. T. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas Aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. Molecules 2018, 23 (6). https://doi.org/10.3390/molecules23061385. in Molecules. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3141 .

Borges, Anabela, Simoes, Manuel, Todorović, Tamara, Filipović, Nenad R., Garcia-Sosa, Alfonso T., "Supplementary data for the article: Borges, A.; Simões, M.; Todorović, T. R.; Filipović, N. R.; Garcia-Sosa, A. T. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas Aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. Molecules 2018, 23 (6). https://doi.org/10.3390/molecules23061385" in Molecules (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3141 .