TY  - JOUR
AU  - Vujčić, Miroslava
AU  - Lazić, Milan
AU  - Milenković, Milica R.
AU  - Sladić, Dušan
AU  - Radulović, Siniša
AU  - Filipović, Nenad R.
AU  - Anđelković, Katarina K.
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1168
AB  - Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex. (C) 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25: 175-182, 2011; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20374
PB  - Wiley-Blackwell, Malden
T2  - Journal of Biochemical and Molecular Toxicology
T1  - A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide
VL  - 25
IS  - 3
SP  - 175
EP  - 182
DO  - 10.1002/jbt.20374
ER  - 

@article{
author = "Vujčić, Miroslava and Lazić, Milan and Milenković, Milica R. and Sladić, Dušan and Radulović, Siniša and Filipović, Nenad R. and Anđelković, Katarina K.",
year = "2011",
abstract = "Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex. (C) 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25: 175-182, 2011; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20374",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Biochemical and Molecular Toxicology",
title = "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide",
volume = "25",
number = "3",
pages = "175-182",
doi = "10.1002/jbt.20374"
}

Vujčić, M., Lazić, M., Milenković, M. R., Sladić, D., Radulović, S., Filipović, N. R.,& Anđelković, K. K.. (2011). A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology
Wiley-Blackwell, Malden., 25(3), 175-182.
https://doi.org/10.1002/jbt.20374

Vujčić M, Lazić M, Milenković MR, Sladić D, Radulović S, Filipović NR, Anđelković KK. A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology. 2011;25(3):175-182.
doi:10.1002/jbt.20374 .

Vujčić, Miroslava, Lazić, Milan, Milenković, Milica R., Sladić, Dušan, Radulović, Siniša, Filipović, Nenad R., Anđelković, Katarina K., "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide" in Journal of Biochemical and Molecular Toxicology, 25, no. 3 (2011):175-182,
https://doi.org/10.1002/jbt.20374 . .

TY  - JOUR
AU  - Vučković, Ivan M.
AU  - Vujisić, Ljubodrag V.
AU  - Stesevic, Danijela
AU  - Radulović, Siniša
AU  - Lazić, Milan
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1048
AB  - Two epimeric guaianolides were isolated from the aerial parts of Anthemis segetalis. These compounds have not been detected in any Anthemis species so far. One of them was tested for cytotoxicity against human cervical cancer (HeLa) and murine melanoma (B16) cell lines showing appreciable activity. copyright (C) 2009 John Wiley & Sons, Ltd.
PB  - John Wiley & Sons Ltd, Chichester
T2  - Phytotherapy Research
T1  - Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)
VL  - 24
IS  - 2
SP  - 225
EP  - 227
DO  - 10.1002/ptr.2916
ER  - 

@article{
author = "Vučković, Ivan M. and Vujisić, Ljubodrag V. and Stesevic, Danijela and Radulović, Siniša and Lazić, Milan and Milosavljević, Slobodan M.",
year = "2010",
abstract = "Two epimeric guaianolides were isolated from the aerial parts of Anthemis segetalis. These compounds have not been detected in any Anthemis species so far. One of them was tested for cytotoxicity against human cervical cancer (HeLa) and murine melanoma (B16) cell lines showing appreciable activity. copyright (C) 2009 John Wiley & Sons, Ltd.",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Phytotherapy Research",
title = "Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)",
volume = "24",
number = "2",
pages = "225-227",
doi = "10.1002/ptr.2916"
}

Vučković, I. M., Vujisić, L. V., Stesevic, D., Radulović, S., Lazić, M.,& Milosavljević, S. M.. (2010). Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae). in Phytotherapy Research
John Wiley & Sons Ltd, Chichester., 24(2), 225-227.
https://doi.org/10.1002/ptr.2916

Vučković IM, Vujisić LV, Stesevic D, Radulović S, Lazić M, Milosavljević SM. Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae). in Phytotherapy Research. 2010;24(2):225-227.
doi:10.1002/ptr.2916 .

Vučković, Ivan M., Vujisić, Ljubodrag V., Stesevic, Danijela, Radulović, Siniša, Lazić, Milan, Milosavljević, Slobodan M., "Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)" in Phytotherapy Research, 24, no. 2 (2010):225-227,
https://doi.org/10.1002/ptr.2916 . .

TY  - JOUR
AU  - Atrrog, Abubaker A. B.
AU  - Natić, Maja
AU  - Tosti, Tomislav
AU  - Milojković-Opsenica, Dušanka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan M.
AU  - Lazić, Milan
AU  - Radulović, Siniša
AU  - Tešić, Živoslav Lj.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/609
AB  - In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R(M)(0) and C(0). Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC(50) values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright (C) 2008 John Wiley & Sons, Ltd.
PB  - John Wiley & Sons Ltd, Chichester
T2  - Biomedical Chromatography
T1  - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
VL  - 23
IS  - 3
SP  - 250
EP  - 256
DO  - 10.1002/bmc.1091
ER  - 

@article{
author = "Atrrog, Abubaker A. B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Đorđević, Iris and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan M. and Lazić, Milan and Radulović, Siniša and Tešić, Živoslav Lj.",
year = "2009",
abstract = "In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R(M)(0) and C(0). Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC(50) values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright (C) 2008 John Wiley & Sons, Ltd.",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Biomedical Chromatography",
title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro",
volume = "23",
number = "3",
pages = "250-256",
doi = "10.1002/bmc.1091"
}

Atrrog, A. A. B., Natić, M., Tosti, T., Milojković-Opsenica, D., Đorđević, I., Tešević, V., Jadranin, M., Milosavljević, S. M., Lazić, M., Radulović, S.,& Tešić, Ž. Lj.. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography
John Wiley & Sons Ltd, Chichester., 23(3), 250-256.
https://doi.org/10.1002/bmc.1091

Atrrog AAB, Natić M, Tosti T, Milojković-Opsenica D, Đorđević I, Tešević V, Jadranin M, Milosavljević SM, Lazić M, Radulović S, Tešić ŽL. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography. 2009;23(3):250-256.
doi:10.1002/bmc.1091 .

Atrrog, Abubaker A. B., Natić, Maja, Tosti, Tomislav, Milojković-Opsenica, Dušanka, Đorđević, Iris, Tešević, Vele, Jadranin, Milka, Milosavljević, Slobodan M., Lazić, Milan, Radulović, Siniša, Tešić, Živoslav Lj., "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" in Biomedical Chromatography, 23, no. 3 (2009):250-256,
https://doi.org/10.1002/bmc.1091 . .

TY  - JOUR
AU  - Filipović, Nenad R.
AU  - Bacchi, Alessia
AU  - Lazić, Milan
AU  - Pelizzi, Giancarlo
AU  - Radulović, Siniša
AU  - Sladić, Dušan
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/913
AB  - A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells. (c) 2007 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Inorganic Chemistry Communications
T1  - Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide
VL  - 11
IS  - 1
SP  - 47
EP  - 50
DO  - 10.1016/j.inoche.2007.10.013
ER  - 

@article{
author = "Filipović, Nenad R. and Bacchi, Alessia and Lazić, Milan and Pelizzi, Giancarlo and Radulović, Siniša and Sladić, Dušan and Todorović, Tamara and Anđelković, Katarina K.",
year = "2008",
abstract = "A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells. (c) 2007 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Inorganic Chemistry Communications",
title = "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide",
volume = "11",
number = "1",
pages = "47-50",
doi = "10.1016/j.inoche.2007.10.013"
}

Filipović, N. R., Bacchi, A., Lazić, M., Pelizzi, G., Radulović, S., Sladić, D., Todorović, T.,& Anđelković, K. K.. (2008). Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications
Elsevier Science Bv, Amsterdam., 11(1), 47-50.
https://doi.org/10.1016/j.inoche.2007.10.013

Filipović NR, Bacchi A, Lazić M, Pelizzi G, Radulović S, Sladić D, Todorović T, Anđelković KK. Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications. 2008;11(1):47-50.
doi:10.1016/j.inoche.2007.10.013 .

Filipović, Nenad R., Bacchi, Alessia, Lazić, Milan, Pelizzi, Giancarlo, Radulović, Siniša, Sladić, Dušan, Todorović, Tamara, Anđelković, Katarina K., "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide" in Inorganic Chemistry Communications, 11, no. 1 (2008):47-50,
https://doi.org/10.1016/j.inoche.2007.10.013 . .