TY  - JOUR
AU  - Kaludjerovic, GN
AU  - Miljković, Đorđe
AU  - Momčilović, Miljana
AU  - Djinovic, VM
AU  - Stojkovic, MM
AU  - Sabo, Tibor
AU  - Trajković, Vladimir S.
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/719
AB  - The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. (C) 2005 Wiley-Liss, Inc.
PB  - Wiley, Hoboken
T2  - International Journal of Cancer
T1  - Novel platinum(IV) complexes induce rapid tumor cell death in vitro
VL  - 116
IS  - 3
SP  - 479
EP  - 486
DO  - 10.1002/ijc.21080
ER  - 

@article{
author = "Kaludjerovic, GN and Miljković, Đorđe and Momčilović, Miljana and Djinovic, VM and Stojkovic, MM and Sabo, Tibor and Trajković, Vladimir S.",
year = "2005",
abstract = "The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. (C) 2005 Wiley-Liss, Inc.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Cancer",
title = "Novel platinum(IV) complexes induce rapid tumor cell death in vitro",
volume = "116",
number = "3",
pages = "479-486",
doi = "10.1002/ijc.21080"
}

Kaludjerovic, G., Miljković, Đ., Momčilović, M., Djinovic, V., Stojkovic, M., Sabo, T.,& Trajković, V. S.. (2005). Novel platinum(IV) complexes induce rapid tumor cell death in vitro. in International Journal of Cancer
Wiley, Hoboken., 116(3), 479-486.
https://doi.org/10.1002/ijc.21080

Kaludjerovic G, Miljković Đ, Momčilović M, Djinovic V, Stojkovic M, Sabo T, Trajković VS. Novel platinum(IV) complexes induce rapid tumor cell death in vitro. in International Journal of Cancer. 2005;116(3):479-486.
doi:10.1002/ijc.21080 .

Kaludjerovic, GN, Miljković, Đorđe, Momčilović, Miljana, Djinovic, VM, Stojkovic, MM, Sabo, Tibor, Trajković, Vladimir S., "Novel platinum(IV) complexes induce rapid tumor cell death in vitro" in International Journal of Cancer, 116, no. 3 (2005):479-486,
https://doi.org/10.1002/ijc.21080 . .

TY  - JOUR
AU  - Mijatovic, S
AU  - Maksimovic-Ivanic, D
AU  - Radovic, J
AU  - Miljković, Đorđe
AU  - Kaludjerovic, GN
AU  - Sabo, Tibor
AU  - Trajković, Vladimir S.
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/733
AB  - The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of DNA fragmentation or phosphatidylserine exposure. Cell-based ELISA and Western blot analysis revealed that AE abolished cisplatin-triggered activation of extracellular signal-regulated kinase (ERK) in tumor cells, while activation of c-Jun N-terminal kinase was not significantly altered. A selective blockade of ERK activation with PD98059 mimicked the protective effect of AE treatment in both tumor cell lines. Moreover, AE failed to protect tumor cells against the ERK-independent toxicity of the Pt(IV)-based complex tetrachloro(O,O-dibutyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV). Taken together, these data indicate that herbal anthraquinone AE can downregulate the anticancer activity of cisplatin by blocking the activation of ERK in tumor cells.
PB  - Birkhauser Verlag Ag, Basel
T2  - Cellular and Molecular Life Sciences / CMLS
T1  - Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin
VL  - 62
IS  - 11
SP  - 1275
EP  - 1282
DO  - 10.1007/s00018-005-5041-3
ER  - 

@article{
author = "Mijatovic, S and Maksimovic-Ivanic, D and Radovic, J and Miljković, Đorđe and Kaludjerovic, GN and Sabo, Tibor and Trajković, Vladimir S.",
year = "2005",
abstract = "The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of DNA fragmentation or phosphatidylserine exposure. Cell-based ELISA and Western blot analysis revealed that AE abolished cisplatin-triggered activation of extracellular signal-regulated kinase (ERK) in tumor cells, while activation of c-Jun N-terminal kinase was not significantly altered. A selective blockade of ERK activation with PD98059 mimicked the protective effect of AE treatment in both tumor cell lines. Moreover, AE failed to protect tumor cells against the ERK-independent toxicity of the Pt(IV)-based complex tetrachloro(O,O-dibutyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV). Taken together, these data indicate that herbal anthraquinone AE can downregulate the anticancer activity of cisplatin by blocking the activation of ERK in tumor cells.",
publisher = "Birkhauser Verlag Ag, Basel",
journal = "Cellular and Molecular Life Sciences / CMLS",
title = "Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin",
volume = "62",
number = "11",
pages = "1275-1282",
doi = "10.1007/s00018-005-5041-3"
}

Mijatovic, S., Maksimovic-Ivanic, D., Radovic, J., Miljković, Đ., Kaludjerovic, G., Sabo, T.,& Trajković, V. S.. (2005). Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. in Cellular and Molecular Life Sciences / CMLS
Birkhauser Verlag Ag, Basel., 62(11), 1275-1282.
https://doi.org/10.1007/s00018-005-5041-3

Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljković Đ, Kaludjerovic G, Sabo T, Trajković VS. Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. in Cellular and Molecular Life Sciences / CMLS. 2005;62(11):1275-1282.
doi:10.1007/s00018-005-5041-3 .

Mijatovic, S, Maksimovic-Ivanic, D, Radovic, J, Miljković, Đorđe, Kaludjerovic, GN, Sabo, Tibor, Trajković, Vladimir S., "Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin" in Cellular and Molecular Life Sciences / CMLS, 62, no. 11 (2005):1275-1282,
https://doi.org/10.1007/s00018-005-5041-3 . .

TY  - JOUR
AU  - Kaludjerovic, GN
AU  - Heinemann, FW
AU  - Leovac, Vukadin M.
AU  - Trifunović, Srećko R.
AU  - Sabo, Tibor
PY  - 2003
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/562
AB  - In the anion of the title compound, (C2H10N2)[VO(H2O)(C3H2O4)(2)] or H(2)en[VO(mal)(2)H2O], vanadium(IV) is distorted-octahedrally coordinated by six donor O atoms. The two malonate ligands are situated in the equatorial plane, whereas the oxo and the water ligand occupy axial positions. The apical V=O bond exhibits a strong trans influence. The anion possesses crystallographically imposed C-2 symmetry, with the central V atom, the oxo and the water ligand lying on the twofold axis.
PB  - Blackwell Munksgaard, Copenhagen
T2  - Acta Crystallographica. Section E: Structure Reports Online
T1  - Ethylenediammonium aquabis(malonato)oxovanadate(IV)
VL  - 59
IS  - 7
DO  - 10.1107/S160053680301417X
ER  - 

@article{
author = "Kaludjerovic, GN and Heinemann, FW and Leovac, Vukadin M. and Trifunović, Srećko R. and Sabo, Tibor",
year = "2003",
abstract = "In the anion of the title compound, (C2H10N2)[VO(H2O)(C3H2O4)(2)] or H(2)en[VO(mal)(2)H2O], vanadium(IV) is distorted-octahedrally coordinated by six donor O atoms. The two malonate ligands are situated in the equatorial plane, whereas the oxo and the water ligand occupy axial positions. The apical V=O bond exhibits a strong trans influence. The anion possesses crystallographically imposed C-2 symmetry, with the central V atom, the oxo and the water ligand lying on the twofold axis.",
publisher = "Blackwell Munksgaard, Copenhagen",
journal = "Acta Crystallographica. Section E: Structure Reports Online",
title = "Ethylenediammonium aquabis(malonato)oxovanadate(IV)",
volume = "59",
number = "7",
doi = "10.1107/S160053680301417X"
}

Kaludjerovic, G., Heinemann, F., Leovac, V. M., Trifunović, S. R.,& Sabo, T.. (2003). Ethylenediammonium aquabis(malonato)oxovanadate(IV). in Acta Crystallographica. Section E: Structure Reports Online
Blackwell Munksgaard, Copenhagen., 59(7).
https://doi.org/10.1107/S160053680301417X

Kaludjerovic G, Heinemann F, Leovac VM, Trifunović SR, Sabo T. Ethylenediammonium aquabis(malonato)oxovanadate(IV). in Acta Crystallographica. Section E: Structure Reports Online. 2003;59(7).
doi:10.1107/S160053680301417X .

Kaludjerovic, GN, Heinemann, FW, Leovac, Vukadin M., Trifunović, Srećko R., Sabo, Tibor, "Ethylenediammonium aquabis(malonato)oxovanadate(IV)" in Acta Crystallographica. Section E: Structure Reports Online, 59, no. 7 (2003),
https://doi.org/10.1107/S160053680301417X . .

TY  - JOUR
AU  - Kaludjerovic, GN
AU  - Djinovic, VM
AU  - Trifunović, Srećko R.
AU  - Hodzic, IM
AU  - Sabo, Tibor
PY  - 2002
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/483
AB  - A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmPhipdtc) was prepared, as the sodium salt. In the reaction of hexaaminecobalt(III) chloride with NabmPhipdtc, the corresponding tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]cobalt(III), [Co(bmPhipdtc)(3)] complex was prepared. The complex was characterized by elemental analysis, infrared, electronic absorption, H-1 and C-13-NMR spectroscopy.
AB  - Sintetisan je novi bidentatni ligand butil-(1-metil-3-fenil-propil)-ditiokarbamat (bmΦpdtc), kao natrijumova so. Reakcijom heksaamminkobalt(III)-hlorida i navedenog liganda dobijen je odgovarajući kompleks tris[butil-(1-metil-3-fenil-propil) ditiokarbamato]kobalt(III), [Co(bmΦpdtc)3]. Kompleks je okarakterisan elementalnom analizom, infracrvenim, elektronsko-apsorpcionim, 1H i 13C-NMR spektrima.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis and characterization of tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]-cobalt(III) seskvitoluene
T1  - Sinteza i karakterizacija tris [butil-(1-metil-3-fenil-propil)-ditiokarbamato]-kobalt(III) seskvitoluena
VL  - 67
IS  - 2
SP  - 123
EP  - 126
DO  - 10.2298/JSC0202123K
ER  - 

@article{
author = "Kaludjerovic, GN and Djinovic, VM and Trifunović, Srećko R. and Hodzic, IM and Sabo, Tibor",
year = "2002",
abstract = "A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmPhipdtc) was prepared, as the sodium salt. In the reaction of hexaaminecobalt(III) chloride with NabmPhipdtc, the corresponding tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]cobalt(III), [Co(bmPhipdtc)(3)] complex was prepared. The complex was characterized by elemental analysis, infrared, electronic absorption, H-1 and C-13-NMR spectroscopy., Sintetisan je novi bidentatni ligand butil-(1-metil-3-fenil-propil)-ditiokarbamat (bmΦpdtc), kao natrijumova so. Reakcijom heksaamminkobalt(III)-hlorida i navedenog liganda dobijen je odgovarajući kompleks tris[butil-(1-metil-3-fenil-propil) ditiokarbamato]kobalt(III), [Co(bmΦpdtc)3]. Kompleks je okarakterisan elementalnom analizom, infracrvenim, elektronsko-apsorpcionim, 1H i 13C-NMR spektrima.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis and characterization of tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]-cobalt(III) seskvitoluene, Sinteza i karakterizacija tris [butil-(1-metil-3-fenil-propil)-ditiokarbamato]-kobalt(III) seskvitoluena",
volume = "67",
number = "2",
pages = "123-126",
doi = "10.2298/JSC0202123K"
}

Kaludjerovic, G., Djinovic, V., Trifunović, S. R., Hodzic, I.,& Sabo, T.. (2002). Synthesis and characterization of tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]-cobalt(III) seskvitoluene. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 67(2), 123-126.
https://doi.org/10.2298/JSC0202123K

Kaludjerovic G, Djinovic V, Trifunović SR, Hodzic I, Sabo T. Synthesis and characterization of tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]-cobalt(III) seskvitoluene. in Journal of the Serbian Chemical Society. 2002;67(2):123-126.
doi:10.2298/JSC0202123K .

Kaludjerovic, GN, Djinovic, VM, Trifunović, Srećko R., Hodzic, IM, Sabo, Tibor, "Synthesis and characterization of tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]-cobalt(III) seskvitoluene" in Journal of the Serbian Chemical Society, 67, no. 2 (2002):123-126,
https://doi.org/10.2298/JSC0202123K . .