TY  - JOUR
AU  - Petković, Branka B.
AU  - Kuzmanović, Darko
AU  - Dimitrijević, Teodora
AU  - Krstic, M. P.
AU  - Stanković, Dalibor
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2465
AB  - A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination
VL  - 12
IS  - 5
SP  - 3709
EP  - 3720
DO  - 10.20964/2017.05.34
ER  - 

@article{
author = "Petković, Branka B. and Kuzmanović, Darko and Dimitrijević, Teodora and Krstic, M. P. and Stanković, Dalibor",
year = "2017",
abstract = "A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination",
volume = "12",
number = "5",
pages = "3709-3720",
doi = "10.20964/2017.05.34"
}

Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstic, M. P.,& Stanković, D.. (2017). Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science
Esg, Belgrade., 12(5), 3709-3720.
https://doi.org/10.20964/2017.05.34

Petković BB, Kuzmanović D, Dimitrijević T, Krstic MP, Stanković D. Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science. 2017;12(5):3709-3720.
doi:10.20964/2017.05.34 .

Petković, Branka B., Kuzmanović, Darko, Dimitrijević, Teodora, Krstic, M. P., Stanković, Dalibor, "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination" in International Journal of Electrochemical Science, 12, no. 5 (2017):3709-3720,
https://doi.org/10.20964/2017.05.34 . .

TY  - JOUR
AU  - Stanković, Dalibor
AU  - Dimitrijević, Teodora
AU  - Kuzmanović, Darko
AU  - Krstic, M. P.
AU  - Petković, Branka B.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2018
AB  - A simple and efficient procedure is described for electrochemical determination of trifluoperazine (TFP), a prominent compound in a large group of phenothiazine derivatives with potent physiological activity. This method is based on the electrochemical oxidation of TFP in Britton-Robinson buffer solution in pH 6 at a boron-doped diamond electrode. Cyclic voltammetry provided a four well defined oxidation peaks at + 0.65, + 0.83, + 1.06 and + 1.35 V (vs. Ag/AgCl/3 M KCl electrode). Differential pulse voltammetry was applied as a very sensitive analytical technique for the determination of micromolar amounts of TFP. Two oxidation peaks on higher potentials were chosen for quantification of TFP. Under optimized conditions, the analytical curves obtained were linear in the TFP concentration range of 1.0 to 37.0 mmol L-1, with a detection limit of 0.7 and 0.6 mmol L-1, respectively. The effect of interfering agents (common urinary compounds) appeared to be negligible confirming the favourable selectivity of the method. The proposed method was analytically applied by determination of trifluoperazine content in model human urine samples with good accuracy (recoveries varied from 97% to 104%). The developed approach could be beneficial in analysis of TFP in biological samples using a boron-doped diamond electrode as an up-to-date electrochemical sensor and could represent an inexpensive analytical alternative to separation methods.
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine
VL  - 5
IS  - 129
SP  - 107058
EP  - 107063
DO  - 10.1039/c5ra18783d
ER  - 

@article{
author = "Stanković, Dalibor and Dimitrijević, Teodora and Kuzmanović, Darko and Krstic, M. P. and Petković, Branka B.",
year = "2015",
abstract = "A simple and efficient procedure is described for electrochemical determination of trifluoperazine (TFP), a prominent compound in a large group of phenothiazine derivatives with potent physiological activity. This method is based on the electrochemical oxidation of TFP in Britton-Robinson buffer solution in pH 6 at a boron-doped diamond electrode. Cyclic voltammetry provided a four well defined oxidation peaks at + 0.65, + 0.83, + 1.06 and + 1.35 V (vs. Ag/AgCl/3 M KCl electrode). Differential pulse voltammetry was applied as a very sensitive analytical technique for the determination of micromolar amounts of TFP. Two oxidation peaks on higher potentials were chosen for quantification of TFP. Under optimized conditions, the analytical curves obtained were linear in the TFP concentration range of 1.0 to 37.0 mmol L-1, with a detection limit of 0.7 and 0.6 mmol L-1, respectively. The effect of interfering agents (common urinary compounds) appeared to be negligible confirming the favourable selectivity of the method. The proposed method was analytically applied by determination of trifluoperazine content in model human urine samples with good accuracy (recoveries varied from 97% to 104%). The developed approach could be beneficial in analysis of TFP in biological samples using a boron-doped diamond electrode as an up-to-date electrochemical sensor and could represent an inexpensive analytical alternative to separation methods.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine",
volume = "5",
number = "129",
pages = "107058-107063",
doi = "10.1039/c5ra18783d"
}

Stanković, D., Dimitrijević, T., Kuzmanović, D., Krstic, M. P.,& Petković, B. B.. (2015). Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine. in RSC Advances
Royal Soc Chemistry, Cambridge., 5(129), 107058-107063.
https://doi.org/10.1039/c5ra18783d

Stanković D, Dimitrijević T, Kuzmanović D, Krstic MP, Petković BB. Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine. in RSC Advances. 2015;5(129):107058-107063.
doi:10.1039/c5ra18783d .

Stanković, Dalibor, Dimitrijević, Teodora, Kuzmanović, Darko, Krstic, M. P., Petković, Branka B., "Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine" in RSC Advances, 5, no. 129 (2015):107058-107063,
https://doi.org/10.1039/c5ra18783d . .