TY  - JOUR
AU  - Dumanović, Jelena
AU  - Nepovimova, Eugenie
AU  - Natić, Maja
AU  - Kuča, Kamil
AU  - Jaćević, Vesna
PY  - 2021
UR  - https://www.frontiersin.org/articles/10.3389/fpls.2020.552969/full
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4452
AB  - In plants, there's a complex and multilevel network of the antioxidative system (AOS) operating to counteract harmful reactive species (RS), the foremost important of which are reactive oxygen species (ROS), and maintain homeostasis within the cell. Specific AOSs for plant cells are, first and foremost, enzymes of the glutathione-ascorbate cycle (Asc-GSH), followed by phenolic compounds and lipophilic antioxidants like carotenoids and tocopherols. Evidence that plant cells have excellent antioxidative defence systems is their ability to survive at H2O2 concentrations incompatible with animal cell life. For the survival of stressed plants, it's of particular importance that AOS cooperate and participate in redox reactions, therefore providing better protection and regeneration of the active reduced forms. Considering that plants abound in antioxidant compounds, and humans are not predisposed to synthesize the majority of them, new fields of research have emerged. Antioxidant potential of plant compounds has been exploited for antiaging formulations preparation, food fortification and preservation, but also in designing new therapies for diseases with oxidative stress implicated in aetiology.
PB  - Frontiers
T2  - Frontiers in Plant Science
T1  - The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview
VL  - 11
SP  - 552969
DO  - 10.3389/fpls.2020.552969
ER  - 

@article{
author = "Dumanović, Jelena and Nepovimova, Eugenie and Natić, Maja and Kuča, Kamil and Jaćević, Vesna",
year = "2021",
abstract = "In plants, there's a complex and multilevel network of the antioxidative system (AOS) operating to counteract harmful reactive species (RS), the foremost important of which are reactive oxygen species (ROS), and maintain homeostasis within the cell. Specific AOSs for plant cells are, first and foremost, enzymes of the glutathione-ascorbate cycle (Asc-GSH), followed by phenolic compounds and lipophilic antioxidants like carotenoids and tocopherols. Evidence that plant cells have excellent antioxidative defence systems is their ability to survive at H2O2 concentrations incompatible with animal cell life. For the survival of stressed plants, it's of particular importance that AOS cooperate and participate in redox reactions, therefore providing better protection and regeneration of the active reduced forms. Considering that plants abound in antioxidant compounds, and humans are not predisposed to synthesize the majority of them, new fields of research have emerged. Antioxidant potential of plant compounds has been exploited for antiaging formulations preparation, food fortification and preservation, but also in designing new therapies for diseases with oxidative stress implicated in aetiology.",
publisher = "Frontiers",
journal = "Frontiers in Plant Science",
title = "The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview",
volume = "11",
pages = "552969",
doi = "10.3389/fpls.2020.552969"
}

Dumanović, J., Nepovimova, E., Natić, M., Kuča, K.,& Jaćević, V.. (2021). The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview. in Frontiers in Plant Science
Frontiers., 11, 552969.
https://doi.org/10.3389/fpls.2020.552969

Dumanović J, Nepovimova E, Natić M, Kuča K, Jaćević V. The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview. in Frontiers in Plant Science. 2021;11:552969.
doi:10.3389/fpls.2020.552969 .

Dumanović, Jelena, Nepovimova, Eugenie, Natić, Maja, Kuča, Kamil, Jaćević, Vesna, "The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview" in Frontiers in Plant Science, 11 (2021):552969,
https://doi.org/10.3389/fpls.2020.552969 . .

TY  - JOUR
AU  - Jaćević, Vesna
AU  - Dumanović, Jelena
AU  - Lazarević, Miodrag
AU  - Nepovimova, Eugenie
AU  - Resanović, Radmila
AU  - Milovanović, Zoran
AU  - Wu, Qinghua
AU  - Kuča, Kamil
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4258
AB  - In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.
PB  - MDPI
T2  - Toxins
T1  - Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin
VL  - 12
IS  - 10
SP  - 643
DO  - 10.3390/toxins12100643
ER  - 

@article{
author = "Jaćević, Vesna and Dumanović, Jelena and Lazarević, Miodrag and Nepovimova, Eugenie and Resanović, Radmila and Milovanović, Zoran and Wu, Qinghua and Kuča, Kamil",
year = "2020",
abstract = "In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.",
publisher = "MDPI",
journal = "Toxins",
title = "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin",
volume = "12",
number = "10",
pages = "643",
doi = "10.3390/toxins12100643"
}

Jaćević, V., Dumanović, J., Lazarević, M., Nepovimova, E., Resanović, R., Milovanović, Z., Wu, Q.,& Kuča, K.. (2020). Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins
MDPI., 12(10), 643.
https://doi.org/10.3390/toxins12100643

Jaćević V, Dumanović J, Lazarević M, Nepovimova E, Resanović R, Milovanović Z, Wu Q, Kuča K. Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins. 2020;12(10):643.
doi:10.3390/toxins12100643 .

Jaćević, Vesna, Dumanović, Jelena, Lazarević, Miodrag, Nepovimova, Eugenie, Resanović, Radmila, Milovanović, Zoran, Wu, Qinghua, Kuča, Kamil, "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin" in Toxins, 12, no. 10 (2020):643,
https://doi.org/10.3390/toxins12100643 . .