TY  - JOUR
AU  - Leong, Patrick P. T.
AU  - Mihajlović, Aleksandar
AU  - Bogdanović, Nadežda
AU  - Breberina, Luka M.
AU  - Xi, Larry
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4685
AB  - Single-cell sequencing provides a new level of granularity in studying the heterogeneous nature of cancer cells. For some cancers, this heterogeneity is the result of copy number changes of genes within the cellular genomes. The ability to accurately determine such copy number changes is critical in tracing and understanding tumorigenesis. Current single-cell genome sequencing methodologies infer copy numbers based on statistical approaches followed by rounding decimal numbers to integer values. Such methodologies are sample dependent, have varying calling sensitivities which heavily depend on the sample’s ploidy and are sensitive to noise in sequencing data. In this paper we have demonstrated the concept of integer-counting by using a novel bioinformatic algorithm built on our library construction chemistry in order to detect the discrete nature of the genome.
PB  - Nature Research
T2  - Scientific Reports
T1  - Reconstructing and counting genomic fragments through tagmentation-based haploid phasing
VL  - 11
IS  - 1
SP  - 18907
DO  - 10.1038/s41598-021-97852-w
ER  - 

@article{
author = "Leong, Patrick P. T. and Mihajlović, Aleksandar and Bogdanović, Nadežda and Breberina, Luka M. and Xi, Larry",
year = "2021",
abstract = "Single-cell sequencing provides a new level of granularity in studying the heterogeneous nature of cancer cells. For some cancers, this heterogeneity is the result of copy number changes of genes within the cellular genomes. The ability to accurately determine such copy number changes is critical in tracing and understanding tumorigenesis. Current single-cell genome sequencing methodologies infer copy numbers based on statistical approaches followed by rounding decimal numbers to integer values. Such methodologies are sample dependent, have varying calling sensitivities which heavily depend on the sample’s ploidy and are sensitive to noise in sequencing data. In this paper we have demonstrated the concept of integer-counting by using a novel bioinformatic algorithm built on our library construction chemistry in order to detect the discrete nature of the genome.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Reconstructing and counting genomic fragments through tagmentation-based haploid phasing",
volume = "11",
number = "1",
pages = "18907",
doi = "10.1038/s41598-021-97852-w"
}

Leong, P. P. T., Mihajlović, A., Bogdanović, N., Breberina, L. M.,& Xi, L.. (2021). Reconstructing and counting genomic fragments through tagmentation-based haploid phasing. in Scientific Reports
Nature Research., 11(1), 18907.
https://doi.org/10.1038/s41598-021-97852-w

Leong PPT, Mihajlović A, Bogdanović N, Breberina LM, Xi L. Reconstructing and counting genomic fragments through tagmentation-based haploid phasing. in Scientific Reports. 2021;11(1):18907.
doi:10.1038/s41598-021-97852-w .

Leong, Patrick P. T., Mihajlović, Aleksandar, Bogdanović, Nadežda, Breberina, Luka M., Xi, Larry, "Reconstructing and counting genomic fragments through tagmentation-based haploid phasing" in Scientific Reports, 11, no. 1 (2021):18907,
https://doi.org/10.1038/s41598-021-97852-w . .

TY  - DATA
AU  - Leong, Patrick P. T.
AU  - Mihajlović, Aleksandar
AU  - Bogdanović, Nadežda
AU  - Breberina, Luka M.
AU  - Xi, Larry
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4686
PB  - Nature Research
T2  - Scientific Reports
T1  - Supplementary data for the article: Leong, P. P. T.; Mihajlović, A.; Bogdanović, N.; Breberina, L.; Xi, L. Reconstructing and Counting Genomic Fragments through Tagmentation-Based Haploid Phasing. Sci Rep 2021, 11 (1), 18907. https://doi.org/10.1038/s41598-021-97852-w.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4686
ER  - 

@misc{
author = "Leong, Patrick P. T. and Mihajlović, Aleksandar and Bogdanović, Nadežda and Breberina, Luka M. and Xi, Larry",
year = "2021",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Supplementary data for the article: Leong, P. P. T.; Mihajlović, A.; Bogdanović, N.; Breberina, L.; Xi, L. Reconstructing and Counting Genomic Fragments through Tagmentation-Based Haploid Phasing. Sci Rep 2021, 11 (1), 18907. https://doi.org/10.1038/s41598-021-97852-w.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4686"
}

Leong, P. P. T., Mihajlović, A., Bogdanović, N., Breberina, L. M.,& Xi, L.. (2021). Supplementary data for the article: Leong, P. P. T.; Mihajlović, A.; Bogdanović, N.; Breberina, L.; Xi, L. Reconstructing and Counting Genomic Fragments through Tagmentation-Based Haploid Phasing. Sci Rep 2021, 11 (1), 18907. https://doi.org/10.1038/s41598-021-97852-w.. in Scientific Reports
Nature Research..
https://hdl.handle.net/21.15107/rcub_cherry_4686

Leong PPT, Mihajlović A, Bogdanović N, Breberina LM, Xi L. Supplementary data for the article: Leong, P. P. T.; Mihajlović, A.; Bogdanović, N.; Breberina, L.; Xi, L. Reconstructing and Counting Genomic Fragments through Tagmentation-Based Haploid Phasing. Sci Rep 2021, 11 (1), 18907. https://doi.org/10.1038/s41598-021-97852-w.. in Scientific Reports. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4686 .

Leong, Patrick P. T., Mihajlović, Aleksandar, Bogdanović, Nadežda, Breberina, Luka M., Xi, Larry, "Supplementary data for the article: Leong, P. P. T.; Mihajlović, A.; Bogdanović, N.; Breberina, L.; Xi, L. Reconstructing and Counting Genomic Fragments through Tagmentation-Based Haploid Phasing. Sci Rep 2021, 11 (1), 18907. https://doi.org/10.1038/s41598-021-97852-w." in Scientific Reports (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4686 .