Fawzi Mahomoodally, Mohamad

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Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip

Zengin, Gokhan; Cvetanović, Aleksandra; Gašić, Uroš M.; Stupar, Alena; Bulut, Gizem; Şenkardes, Ismail; Dogan, Ahmet; Ibrahime Sinan, Kouadio; Uysal, Sengul; Aumeeruddy-Elalfi, Zaahira; Aktumsek, Abdurrahman; Fawzi Mahomoodally, Mohamad

(Elsevier, 2020)

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Cvetanović, Aleksandra
AU  - Gašić, Uroš M.
AU  - Stupar, Alena
AU  - Bulut, Gizem
AU  - Şenkardes, Ismail
AU  - Dogan, Ahmet
AU  - Ibrahime Sinan, Kouadio
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahira
AU  - Aktumsek, Abdurrahman
AU  - Fawzi Mahomoodally, Mohamad
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3882
AB  - Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip
VL  - 146
DO  - 10.1016/j.indcrop.2020.112202
ER  - 
@article{
author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Stupar, Alena and Bulut, Gizem and Şenkardes, Ismail and Dogan, Ahmet and Ibrahime Sinan, Kouadio and Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Aktumsek, Abdurrahman and Fawzi Mahomoodally, Mohamad",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3882",
abstract = "Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip",
volume = "146",
doi = "10.1016/j.indcrop.2020.112202"
}
Zengin, G., Cvetanović, A., Gašić, U. M., Stupar, A., Bulut, G., Şenkardes, I., Dogan, A., Ibrahime Sinan, K., Uysal, S., Aumeeruddy-Elalfi, Z., Aktumsek, A.,& Fawzi Mahomoodally, M. (2020). Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip.
Industrial Crops and Products
Elsevier., 146.
https://doi.org/10.1016/j.indcrop.2020.112202
Zengin G, Cvetanović A, Gašić UM, Stupar A, Bulut G, Şenkardes I, Dogan A, Ibrahime Sinan K, Uysal S, Aumeeruddy-Elalfi Z, Aktumsek A, Fawzi Mahomoodally M. Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip. Industrial Crops and Products. 2020;146
Zengin Gokhan, Cvetanović Aleksandra, Gašić Uroš M., Stupar Alena, Bulut Gizem, Şenkardes Ismail, Dogan Ahmet, Ibrahime Sinan Kouadio, Uysal Sengul, Aumeeruddy-Elalfi Zaahira, Aktumsek Abdurrahman, Fawzi Mahomoodally Mohamad, "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip" Industrial Crops and Products, 146 (2020),
https://doi.org/10.1016/j.indcrop.2020.112202 .
6
4
5

Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202

Zengin, Gokhan; Cvetanović, Aleksandra; Gašić, Uroš M.; Stupar, Alena; Bulut, Gizem; Şenkardes, Ismail; Dogan, Ahmet; Ibrahime Sinan, Kouadio; Uysal, Sengul; Aumeeruddy-Elalfi, Zaahira; Aktumsek, Abdurrahman; Fawzi Mahomoodally, Mohamad

(Elsevier, 2020)

TY  - BOOK
AU  - Zengin, Gokhan
AU  - Cvetanović, Aleksandra
AU  - Gašić, Uroš M.
AU  - Stupar, Alena
AU  - Bulut, Gizem
AU  - Şenkardes, Ismail
AU  - Dogan, Ahmet
AU  - Ibrahime Sinan, Kouadio
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahira
AU  - Aktumsek, Abdurrahman
AU  - Fawzi Mahomoodally, Mohamad
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3893
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202
ER  - 
@book{
author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Stupar, Alena and Bulut, Gizem and Şenkardes, Ismail and Dogan, Ahmet and Ibrahime Sinan, Kouadio and Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Aktumsek, Abdurrahman and Fawzi Mahomoodally, Mohamad",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3893",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202"
}
Zengin, G., Cvetanović, A., Gašić, U. M., Stupar, A., Bulut, G., Şenkardes, I., Dogan, A., Ibrahime Sinan, K., Uysal, S., Aumeeruddy-Elalfi, Z., Aktumsek, A.,& Fawzi Mahomoodally, M. (2020). Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202.
Industrial Crops and Products
Elsevier..
Zengin G, Cvetanović A, Gašić UM, Stupar A, Bulut G, Şenkardes I, Dogan A, Ibrahime Sinan K, Uysal S, Aumeeruddy-Elalfi Z, Aktumsek A, Fawzi Mahomoodally M. Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202. Industrial Crops and Products. 2020;
Zengin Gokhan, Cvetanović Aleksandra, Gašić Uroš M., Stupar Alena, Bulut Gizem, Şenkardes Ismail, Dogan Ahmet, Ibrahime Sinan Kouadio, Uysal Sengul, Aumeeruddy-Elalfi Zaahira, Aktumsek Abdurrahman, Fawzi Mahomoodally Mohamad, "Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202" Industrial Crops and Products (2020)