Stanković, Slaviša

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  • Stanković, Slaviša (3)

Author's Bibliography

New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity

Dimkić, Ivica; Petrović, Marija; Gavrilović, Milan; Gašić, Uroš M.; Ristivojević, Petar; Stanković, Slaviša; Janaćković, Peđa T.

(Springer, 2020)

TY  - JOUR
AU  - Dimkić, Ivica
AU  - Petrović, Marija
AU  - Gavrilović, Milan
AU  - Gašić, Uroš M.
AU  - Ristivojević, Petar
AU  - Stanković, Slaviša
AU  - Janaćković, Peđa T.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4260
AB  - Ethnobotanical and ethnopharmacological studies of many Centaurea species indicated their potential in folk medicine so far. However, investigations of different Centaurea calcitrapa L. extracts in terms of cytotoxicity and antimicrobial activity against phytopathogens are generally scarce. The phenolic profile and broad antimicrobial activity (especially towards bacterial phytopathogens) of methanol (MeOH), 70% ethanol (EtOH), ethyl-acetate (EtOAc), 50% acetone (Me2CO) and dichloromethane: methanol (DCM: MeOH, 1: 1) extracts of C. calcitrapa leaves and their potential toxicity on MRC-5 cell line were investigated for the first time. A total of 55 phenolic compounds were identified: 30 phenolic acids and their derivatives, 25 flavonoid glycosides and aglycones. This is also the first report of the presence of centaureidin, jaceidin, kaempferide, nepetin, flavonoid glycosides, phenolic acids and their esters in C. calcitrapa extracts. The best results were obtained with EtOAc extract with lowest MIC values expressed in µg/mL ranging from 13 to 25, while methicillin resistant Staphylococcus aureus was the most susceptible strain. The most susceptible phytopathogens were Pseudomonas syringae pv. syringae, Xanthomonas campestris pv. campestris and Agrobacterium tumefaciens. The highest cytotoxicity was recorded for EtOAc and Me2CO extracts with the lowest relative and absolute IC50 values between 88 and 102 µg/mL, while EtOH extract was the least toxic with predicted relative IC50 value of 1578 µg/mL. Our results indicate that all tested extracts at concentration considered as non-toxic can be one of great importance in combat towards phytopathogenic and human pathogenic strains, as well as natural sources of antimicrobials.
PB  - Springer
T2  - AMB Express
T1  - New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity
VL  - 10
IS  - 1
SP  - 183
DO  - 10.1186/s13568-020-01120-5
ER  - 
@article{
author = "Dimkić, Ivica and Petrović, Marija and Gavrilović, Milan and Gašić, Uroš M. and Ristivojević, Petar and Stanković, Slaviša and Janaćković, Peđa T.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4260",
abstract = "Ethnobotanical and ethnopharmacological studies of many Centaurea species indicated their potential in folk medicine so far. However, investigations of different Centaurea calcitrapa L. extracts in terms of cytotoxicity and antimicrobial activity against phytopathogens are generally scarce. The phenolic profile and broad antimicrobial activity (especially towards bacterial phytopathogens) of methanol (MeOH), 70% ethanol (EtOH), ethyl-acetate (EtOAc), 50% acetone (Me2CO) and dichloromethane: methanol (DCM: MeOH, 1: 1) extracts of C. calcitrapa leaves and their potential toxicity on MRC-5 cell line were investigated for the first time. A total of 55 phenolic compounds were identified: 30 phenolic acids and their derivatives, 25 flavonoid glycosides and aglycones. This is also the first report of the presence of centaureidin, jaceidin, kaempferide, nepetin, flavonoid glycosides, phenolic acids and their esters in C. calcitrapa extracts. The best results were obtained with EtOAc extract with lowest MIC values expressed in µg/mL ranging from 13 to 25, while methicillin resistant Staphylococcus aureus was the most susceptible strain. The most susceptible phytopathogens were Pseudomonas syringae pv. syringae, Xanthomonas campestris pv. campestris and Agrobacterium tumefaciens. The highest cytotoxicity was recorded for EtOAc and Me2CO extracts with the lowest relative and absolute IC50 values between 88 and 102 µg/mL, while EtOH extract was the least toxic with predicted relative IC50 value of 1578 µg/mL. Our results indicate that all tested extracts at concentration considered as non-toxic can be one of great importance in combat towards phytopathogenic and human pathogenic strains, as well as natural sources of antimicrobials.",
publisher = "Springer",
journal = "AMB Express",
title = "New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity",
volume = "10",
number = "1",
pages = "183",
doi = "10.1186/s13568-020-01120-5"
}
Dimkić, I., Petrović, M., Gavrilović, M., Gašić, U. M., Ristivojević, P., Stanković, S.,& Janaćković, P. T. (2020). New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity.
AMB Express
Springer., 10(1), 183.
https://doi.org/10.1186/s13568-020-01120-5
Dimkić I, Petrović M, Gavrilović M, Gašić UM, Ristivojević P, Stanković S, Janaćković PT. New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity. AMB Express. 2020;10(1):183
Dimkić Ivica, Petrović Marija, Gavrilović Milan, Gašić Uroš M., Ristivojević Petar, Stanković Slaviša, Janaćković Peđa T., "New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity" AMB Express, 10, no. 1 (2020):183,
https://doi.org/10.1186/s13568-020-01120-5 .
1
2
1

Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities

Pavlović, Tamara; Dimkić, Ivica; Andrić, Snežana; Milojković-Opsenica, Dušanka; Stanković, Slaviša; Janaćković, Peđa T.; Gavrilović, Milan; Ristivojević, Petar

(Elsevier, 2020)

TY  - JOUR
AU  - Pavlović, Tamara
AU  - Dimkić, Ivica
AU  - Andrić, Snežana
AU  - Milojković-Opsenica, Dušanka
AU  - Stanković, Slaviša
AU  - Janaćković, Peđa T.
AU  - Gavrilović, Milan
AU  - Ristivojević, Petar
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4040
AB  - Linden tea has been used in Serbian folk medicine for centuries to induce sweating for colds, relieve throat irritation and cough, reduce blood pressure, as well as a diuretic, spasmolytic, and as a sedative. The main aim of this study was to determine the comprehensive metabolite profile, free radical scavenging activity, and antimicrobial activities against 23 human and plant pathogens of both commercial and field-collected linden tea samples from Serbia. Developed high-performance thin-layer chromatography (HPTLC) method allowed identification of eight major metabolites in investigated samples, while forty-six metabolites were tentatively identified using high resolution mass spectrometry (HRMS): 14 phenolic acids and their derivatives, 15 glycosides, 9 flavonoids, and 8 procyanidins. Both commercial and field-collected linden tea samples showed similar total phenolic content and radical scavenging activity. Seven compounds such as p-hydroxybenzoic acid 4-O-hexoside, caffeic acid cinnamyl ester, pinocembrin, galangin, luteolin 7-O-glucuronide (and its isomer), isorhamnetin hexosyl hexoside were found in Tilia samples for the first time. Radical reagent 2,2-Diphenyl-1-picrylhydrazyl· (DPPH·) was used in DPPH-HPTLC assay which identified chlorogenic acid, caffeic acid, astragalin, quercitrin, tiliroside, and rutin as compounds that exhibit radical scavenging activity. Tilia samples showed inhibitory effect overwhelming only on Gram-positive bacteria, especially on Bacillus subtilis with the lowest MIC values observed, as well as towards Staphylococcus aureus and oral cavity isolates of Streptococcus pyogenes and Streptococcus mutans. Vaginal isolate of Candida glabrata showed more susceptibility than Candida albicans isolate. Generally, extract from Tilia cordata Miller (L4) showed the highest antimicrobial activity against the most of the tested pathogens, among all field-collected Tilia samples.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities
VL  - 154
SP  - 112639
DO  - 10.1016/j.indcrop.2020.112639
ER  - 
@article{
author = "Pavlović, Tamara and Dimkić, Ivica and Andrić, Snežana and Milojković-Opsenica, Dušanka and Stanković, Slaviša and Janaćković, Peđa T. and Gavrilović, Milan and Ristivojević, Petar",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4040",
abstract = "Linden tea has been used in Serbian folk medicine for centuries to induce sweating for colds, relieve throat irritation and cough, reduce blood pressure, as well as a diuretic, spasmolytic, and as a sedative. The main aim of this study was to determine the comprehensive metabolite profile, free radical scavenging activity, and antimicrobial activities against 23 human and plant pathogens of both commercial and field-collected linden tea samples from Serbia. Developed high-performance thin-layer chromatography (HPTLC) method allowed identification of eight major metabolites in investigated samples, while forty-six metabolites were tentatively identified using high resolution mass spectrometry (HRMS): 14 phenolic acids and their derivatives, 15 glycosides, 9 flavonoids, and 8 procyanidins. Both commercial and field-collected linden tea samples showed similar total phenolic content and radical scavenging activity. Seven compounds such as p-hydroxybenzoic acid 4-O-hexoside, caffeic acid cinnamyl ester, pinocembrin, galangin, luteolin 7-O-glucuronide (and its isomer), isorhamnetin hexosyl hexoside were found in Tilia samples for the first time. Radical reagent 2,2-Diphenyl-1-picrylhydrazyl· (DPPH·) was used in DPPH-HPTLC assay which identified chlorogenic acid, caffeic acid, astragalin, quercitrin, tiliroside, and rutin as compounds that exhibit radical scavenging activity. Tilia samples showed inhibitory effect overwhelming only on Gram-positive bacteria, especially on Bacillus subtilis with the lowest MIC values observed, as well as towards Staphylococcus aureus and oral cavity isolates of Streptococcus pyogenes and Streptococcus mutans. Vaginal isolate of Candida glabrata showed more susceptibility than Candida albicans isolate. Generally, extract from Tilia cordata Miller (L4) showed the highest antimicrobial activity against the most of the tested pathogens, among all field-collected Tilia samples.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities",
volume = "154",
pages = "112639",
doi = "10.1016/j.indcrop.2020.112639"
}
Pavlović, T., Dimkić, I., Andrić, S., Milojković-Opsenica, D., Stanković, S., Janaćković, P. T., Gavrilović, M.,& Ristivojević, P. (2020). Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities.
Industrial Crops and Products
Elsevier., 154, 112639.
https://doi.org/10.1016/j.indcrop.2020.112639
Pavlović T, Dimkić I, Andrić S, Milojković-Opsenica D, Stanković S, Janaćković PT, Gavrilović M, Ristivojević P. Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities. Industrial Crops and Products. 2020;154:112639
Pavlović Tamara, Dimkić Ivica, Andrić Snežana, Milojković-Opsenica Dušanka, Stanković Slaviša, Janaćković Peđa T., Gavrilović Milan, Ristivojević Petar, "Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities" Industrial Crops and Products, 154 (2020):112639,
https://doi.org/10.1016/j.indcrop.2020.112639 .
2
2

Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639

Pavlović, Tamara; Dimkić, Ivica; Andrić, Snežana; Milojković-Opsenica, Dušanka; Stanković, Slaviša; Janaćković, Peđa T.; Gavrilović, Milan; Ristivojević, Petar

(Elsevier, 2020)

TY  - BOOK
AU  - Pavlović, Tamara
AU  - Dimkić, Ivica
AU  - Andrić, Snežana
AU  - Milojković-Opsenica, Dušanka
AU  - Stanković, Slaviša
AU  - Janaćković, Peđa T.
AU  - Gavrilović, Milan
AU  - Ristivojević, Petar
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4041
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639
ER  - 
@book{
author = "Pavlović, Tamara and Dimkić, Ivica and Andrić, Snežana and Milojković-Opsenica, Dušanka and Stanković, Slaviša and Janaćković, Peđa T. and Gavrilović, Milan and Ristivojević, Petar",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4041",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639"
}
Pavlović, T., Dimkić, I., Andrić, S., Milojković-Opsenica, D., Stanković, S., Janaćković, P. T., Gavrilović, M.,& Ristivojević, P. (2020). Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639.
Industrial Crops and Products
Elsevier..
Pavlović T, Dimkić I, Andrić S, Milojković-Opsenica D, Stanković S, Janaćković PT, Gavrilović M, Ristivojević P. Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639. Industrial Crops and Products. 2020;
Pavlović Tamara, Dimkić Ivica, Andrić Snežana, Milojković-Opsenica Dušanka, Stanković Slaviša, Janaćković Peđa T., Gavrilović Milan, Ristivojević Petar, "Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639" Industrial Crops and Products (2020)