Zengin, Gokhan

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  • Zengin, Gokhan (9)
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A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques

Zengin, Gokhan; Cvetanović, Aleksandra; Gašić, Uroš M.; Tešić, Živoslav Lj.; Stupar, Alena; Bulut, Gizem; Sinan, Kouadio Ibrahime; Uysal, Sengul; Picot-Allain, Marie Carene Nancy; Mahomoodally, Mohamad Fawzi

(Elsevier, 2020)

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Cvetanović, Aleksandra
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Stupar, Alena
AU  - Bulut, Gizem
AU  - Sinan, Kouadio Ibrahime
AU  - Uysal, Sengul
AU  - Picot-Allain, Marie Carene Nancy
AU  - Mahomoodally, Mohamad Fawzi
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3963
AB  - We endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [TE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 mg ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited α-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts.
PB  - Elsevier
T2  - Process Biochemistry
T1  - A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques
VL  - 91
SP  - 113
EP  - 125
DO  - 10.1016/j.procbio.2019.12.002
ER  - 
@article{
author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Tešić, Živoslav Lj. and Stupar, Alena and Bulut, Gizem and Sinan, Kouadio Ibrahime and Uysal, Sengul and Picot-Allain, Marie Carene Nancy and Mahomoodally, Mohamad Fawzi",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3963",
abstract = "We endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [TE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 mg ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited α-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts.",
publisher = "Elsevier",
journal = "Process Biochemistry",
title = "A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques",
volume = "91",
pages = "113-125",
doi = "10.1016/j.procbio.2019.12.002"
}
Zengin, G., Cvetanović, A., Gašić, U. M., Tešić, Ž. Lj., Stupar, A., Bulut, G., Sinan, K. I., Uysal, S., Picot-Allain, M. C. N.,& Mahomoodally, M. F. (2020). A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques.
Process Biochemistry
Elsevier., 91, 113-125.
https://doi.org/10.1016/j.procbio.2019.12.002
Zengin G, Cvetanović A, Gašić UM, Tešić ŽL, Stupar A, Bulut G, Sinan KI, Uysal S, Picot-Allain MCN, Mahomoodally MF. A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques. Process Biochemistry. 2020;91:113-125
Zengin Gokhan, Cvetanović Aleksandra, Gašić Uroš M., Tešić Živoslav Lj., Stupar Alena, Bulut Gizem, Sinan Kouadio Ibrahime, Uysal Sengul, Picot-Allain Marie Carene Nancy, Mahomoodally Mohamad Fawzi, "A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques" Process Biochemistry, 91 (2020):113-125,
https://doi.org/10.1016/j.procbio.2019.12.002 .
3
2
3

Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip

Zengin, Gokhan; Cvetanović, Aleksandra; Gašić, Uroš M.; Stupar, Alena; Bulut, Gizem; Şenkardes, Ismail; Dogan, Ahmet; Ibrahime Sinan, Kouadio; Uysal, Sengul; Aumeeruddy-Elalfi, Zaahira; Aktumsek, Abdurrahman; Fawzi Mahomoodally, Mohamad

(Elsevier, 2020)

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Cvetanović, Aleksandra
AU  - Gašić, Uroš M.
AU  - Stupar, Alena
AU  - Bulut, Gizem
AU  - Şenkardes, Ismail
AU  - Dogan, Ahmet
AU  - Ibrahime Sinan, Kouadio
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahira
AU  - Aktumsek, Abdurrahman
AU  - Fawzi Mahomoodally, Mohamad
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3882
AB  - Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip
VL  - 146
DO  - 10.1016/j.indcrop.2020.112202
ER  - 
@article{
author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Stupar, Alena and Bulut, Gizem and Şenkardes, Ismail and Dogan, Ahmet and Ibrahime Sinan, Kouadio and Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Aktumsek, Abdurrahman and Fawzi Mahomoodally, Mohamad",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3882",
abstract = "Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip",
volume = "146",
doi = "10.1016/j.indcrop.2020.112202"
}
Zengin, G., Cvetanović, A., Gašić, U. M., Stupar, A., Bulut, G., Şenkardes, I., Dogan, A., Ibrahime Sinan, K., Uysal, S., Aumeeruddy-Elalfi, Z., Aktumsek, A.,& Fawzi Mahomoodally, M. (2020). Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip.
Industrial Crops and Products
Elsevier., 146.
https://doi.org/10.1016/j.indcrop.2020.112202
Zengin G, Cvetanović A, Gašić UM, Stupar A, Bulut G, Şenkardes I, Dogan A, Ibrahime Sinan K, Uysal S, Aumeeruddy-Elalfi Z, Aktumsek A, Fawzi Mahomoodally M. Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip. Industrial Crops and Products. 2020;146
Zengin Gokhan, Cvetanović Aleksandra, Gašić Uroš M., Stupar Alena, Bulut Gizem, Şenkardes Ismail, Dogan Ahmet, Ibrahime Sinan Kouadio, Uysal Sengul, Aumeeruddy-Elalfi Zaahira, Aktumsek Abdurrahman, Fawzi Mahomoodally Mohamad, "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip" Industrial Crops and Products, 146 (2020),
https://doi.org/10.1016/j.indcrop.2020.112202 .
6
4
5

Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202

Zengin, Gokhan; Cvetanović, Aleksandra; Gašić, Uroš M.; Stupar, Alena; Bulut, Gizem; Şenkardes, Ismail; Dogan, Ahmet; Ibrahime Sinan, Kouadio; Uysal, Sengul; Aumeeruddy-Elalfi, Zaahira; Aktumsek, Abdurrahman; Fawzi Mahomoodally, Mohamad

(Elsevier, 2020)

TY  - BOOK
AU  - Zengin, Gokhan
AU  - Cvetanović, Aleksandra
AU  - Gašić, Uroš M.
AU  - Stupar, Alena
AU  - Bulut, Gizem
AU  - Şenkardes, Ismail
AU  - Dogan, Ahmet
AU  - Ibrahime Sinan, Kouadio
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahira
AU  - Aktumsek, Abdurrahman
AU  - Fawzi Mahomoodally, Mohamad
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3893
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202
ER  - 
@book{
author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Stupar, Alena and Bulut, Gizem and Şenkardes, Ismail and Dogan, Ahmet and Ibrahime Sinan, Kouadio and Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Aktumsek, Abdurrahman and Fawzi Mahomoodally, Mohamad",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3893",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202"
}
Zengin, G., Cvetanović, A., Gašić, U. M., Stupar, A., Bulut, G., Şenkardes, I., Dogan, A., Ibrahime Sinan, K., Uysal, S., Aumeeruddy-Elalfi, Z., Aktumsek, A.,& Fawzi Mahomoodally, M. (2020). Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202.
Industrial Crops and Products
Elsevier..
Zengin G, Cvetanović A, Gašić UM, Stupar A, Bulut G, Şenkardes I, Dogan A, Ibrahime Sinan K, Uysal S, Aumeeruddy-Elalfi Z, Aktumsek A, Fawzi Mahomoodally M. Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202. Industrial Crops and Products. 2020;
Zengin Gokhan, Cvetanović Aleksandra, Gašić Uroš M., Stupar Alena, Bulut Gizem, Şenkardes Ismail, Dogan Ahmet, Ibrahime Sinan Kouadio, Uysal Sengul, Aumeeruddy-Elalfi Zaahira, Aktumsek Abdurrahman, Fawzi Mahomoodally Mohamad, "Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U. M.; Stupar, A.; Bulut, G.; Şenkardes, I.; Dogan, A.; Ibrahime Sinan, K.; Uysal, S.; Aumeeruddy-Elalfi, Z.; Aktumsek, A.; Fawzi Mahomoodally, M. Modern and Traditional Extraction Techniques Affect Chemical Composition and Bioactivity of Tanacetum Parthenium (L.) Sch.Bip. Industrial Crops and Products 2020, 146. https://doi.org/10.1016/j.indcrop.2020.112202" Industrial Crops and Products (2020)

The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts

Cvetanović, Aleksandra; Švarc-Gajić, Jaroslava; Zeković, Zoran P.; Jerković, Jelena; Zengin, Gokhan; Gašić, Uroš M.; Tešić, Živoslav Lj.; Mašković, Pavle; Soares, Cristina; Fatima Barroso, M.; Delerue-Matos, Cristina; Đurović, Saša

(Elsevier Sci Ltd, Oxford, 2019)

TY  - JOUR
AU  - Cvetanović, Aleksandra
AU  - Švarc-Gajić, Jaroslava
AU  - Zeković, Zoran P.
AU  - Jerković, Jelena
AU  - Zengin, Gokhan
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Mašković, Pavle
AU  - Soares, Cristina
AU  - Fatima Barroso, M.
AU  - Delerue-Matos, Cristina
AU  - Đurović, Saša
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2802
AB  - The main goal of this research was to determine the relationship among chemical structure, bioactivity and temperature of chamomile during subcritical water extraction in isobaric conditions (45 bar) at seven different temperatures (65-210 degrees C). The influence of temperature on phenolic profiles was defined by UHPLC-HESI-MS/MS. The overall results indicate that the presence of conjugated double bonds, side chains, glucose moiety or ether moiety in molecules influence the efficiency of polyphenols' extraction in subcritical water. In terms of antioxidant activity, the extracts were the most active towards ABTS radicals (IC50 = 7.3-16.8 mu g/mL), whereby temperature of 150 degrees C was optimal. On the other hand, the extracts obtained at 115 degrees C showed highest cytotoxicity. Inhibition of alpha-amylase and alpha-glucosidase was the highest at 65 and 85 degrees C, i.e. 0.51 and 4.13 mmolAE/g, respectively. Activity against tyrosinase was the highest at 210 degrees C (17.92 mgKAE/g). The data showed that different non-phenolic compounds may also participate in bio-activities of the extracts.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts
VL  - 271
SP  - 328
EP  - 337
DO  - 10.1016/j.foodchem.2018.07.154
ER  - 
@article{
author = "Cvetanović, Aleksandra and Švarc-Gajić, Jaroslava and Zeković, Zoran P. and Jerković, Jelena and Zengin, Gokhan and Gašić, Uroš M. and Tešić, Živoslav Lj. and Mašković, Pavle and Soares, Cristina and Fatima Barroso, M. and Delerue-Matos, Cristina and Đurović, Saša",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2802",
abstract = "The main goal of this research was to determine the relationship among chemical structure, bioactivity and temperature of chamomile during subcritical water extraction in isobaric conditions (45 bar) at seven different temperatures (65-210 degrees C). The influence of temperature on phenolic profiles was defined by UHPLC-HESI-MS/MS. The overall results indicate that the presence of conjugated double bonds, side chains, glucose moiety or ether moiety in molecules influence the efficiency of polyphenols' extraction in subcritical water. In terms of antioxidant activity, the extracts were the most active towards ABTS radicals (IC50 = 7.3-16.8 mu g/mL), whereby temperature of 150 degrees C was optimal. On the other hand, the extracts obtained at 115 degrees C showed highest cytotoxicity. Inhibition of alpha-amylase and alpha-glucosidase was the highest at 65 and 85 degrees C, i.e. 0.51 and 4.13 mmolAE/g, respectively. Activity against tyrosinase was the highest at 210 degrees C (17.92 mgKAE/g). The data showed that different non-phenolic compounds may also participate in bio-activities of the extracts.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts",
volume = "271",
pages = "328-337",
doi = "10.1016/j.foodchem.2018.07.154"
}
Cvetanović, A., Švarc-Gajić, J., Zeković, Z. P., Jerković, J., Zengin, G., Gašić, U. M., Tešić, Ž. Lj., Mašković, P., Soares, C., Fatima Barroso, M., Delerue-Matos, C.,& Đurović, S. (2019). The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts.
Food Chemistry
Elsevier Sci Ltd, Oxford., 271, 328-337.
https://doi.org/10.1016/j.foodchem.2018.07.154
Cvetanović A, Švarc-Gajić J, Zeković ZP, Jerković J, Zengin G, Gašić UM, Tešić ŽL, Mašković P, Soares C, Fatima Barroso M, Delerue-Matos C, Đurović S. The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts. Food Chemistry. 2019;271:328-337
Cvetanović Aleksandra, Švarc-Gajić Jaroslava, Zeković Zoran P., Jerković Jelena, Zengin Gokhan, Gašić Uroš M., Tešić Živoslav Lj., Mašković Pavle, Soares Cristina, Fatima Barroso M., Delerue-Matos Cristina, Đurović Saša, "The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts" Food Chemistry, 271 (2019):328-337,
https://doi.org/10.1016/j.foodchem.2018.07.154 .
30
20
24

Supplementary material for the article: Cvetanovic, A.; Svarc-Gajic, J.; Zekovic, Z.; Jerkovic, J.; Zengin, G.; Gašić, U. M.; Tešić, Ž. L.; Maskovic, P.; Soares, C.; Fatima Barroso, M.; et al. The Influence of the Extraction Temperature on Polyphenolic Profiles and Bioactivity of Chamomile (Matricaria Chamomilla L.) Subcritical Water Extracts. Food Chemistry 2019, 271, 328–337. https://doi.org/10.1016/j.foodchem.2018.07.154

Cvetanović, Aleksandra; Švarc-Gajić, Jaroslava; Zeković, Zoran P.; Jerković, Jelena; Zengin, Gokhan; Gašić, Uroš M.; Tešić, Živoslav Lj.; Mašković, Pavle; Soares, Cristina; Fatima Barroso, M.; Delerue-Matos, Cristina; Đurović, Saša

(Elsevier Sci Ltd, Oxford, 2019)

TY  - BOOK
AU  - Cvetanović, Aleksandra
AU  - Švarc-Gajić, Jaroslava
AU  - Zeković, Zoran P.
AU  - Jerković, Jelena
AU  - Zengin, Gokhan
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Mašković, Pavle
AU  - Soares, Cristina
AU  - Fatima Barroso, M.
AU  - Delerue-Matos, Cristina
AU  - Đurović, Saša
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2972
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Supplementary material for the article: Cvetanovic, A.; Svarc-Gajic, J.; Zekovic, Z.; Jerkovic, J.; Zengin, G.; Gašić, U. M.; Tešić, Ž. L.; Maskovic, P.; Soares, C.; Fatima Barroso, M.; et al. The Influence of the Extraction Temperature on Polyphenolic Profiles and Bioactivity of Chamomile (Matricaria Chamomilla L.) Subcritical Water Extracts. Food Chemistry 2019, 271, 328–337. https://doi.org/10.1016/j.foodchem.2018.07.154
ER  - 
@book{
author = "Cvetanović, Aleksandra and Švarc-Gajić, Jaroslava and Zeković, Zoran P. and Jerković, Jelena and Zengin, Gokhan and Gašić, Uroš M. and Tešić, Živoslav Lj. and Mašković, Pavle and Soares, Cristina and Fatima Barroso, M. and Delerue-Matos, Cristina and Đurović, Saša",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2972",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Supplementary material for the article: Cvetanovic, A.; Svarc-Gajic, J.; Zekovic, Z.; Jerkovic, J.; Zengin, G.; Gašić, U. M.; Tešić, Ž. L.; Maskovic, P.; Soares, C.; Fatima Barroso, M.; et al. The Influence of the Extraction Temperature on Polyphenolic Profiles and Bioactivity of Chamomile (Matricaria Chamomilla L.) Subcritical Water Extracts. Food Chemistry 2019, 271, 328–337. https://doi.org/10.1016/j.foodchem.2018.07.154"
}
Cvetanović, A., Švarc-Gajić, J., Zeković, Z. P., Jerković, J., Zengin, G., Gašić, U. M., Tešić, Ž. Lj., Mašković, P., Soares, C., Fatima Barroso, M., Delerue-Matos, C.,& Đurović, S. (2019). Supplementary material for the article: Cvetanovic, A.; Svarc-Gajic, J.; Zekovic, Z.; Jerkovic, J.; Zengin, G.; Gašić, U. M.; Tešić, Ž. L.; Maskovic, P.; Soares, C.; Fatima Barroso, M.; et al. The Influence of the Extraction Temperature on Polyphenolic Profiles and Bioactivity of Chamomile (Matricaria Chamomilla L.) Subcritical Water Extracts. Food Chemistry 2019, 271, 328–337. https://doi.org/10.1016/j.foodchem.2018.07.154.
Food Chemistry
Elsevier Sci Ltd, Oxford..
Cvetanović A, Švarc-Gajić J, Zeković ZP, Jerković J, Zengin G, Gašić UM, Tešić ŽL, Mašković P, Soares C, Fatima Barroso M, Delerue-Matos C, Đurović S. Supplementary material for the article: Cvetanovic, A.; Svarc-Gajic, J.; Zekovic, Z.; Jerkovic, J.; Zengin, G.; Gašić, U. M.; Tešić, Ž. L.; Maskovic, P.; Soares, C.; Fatima Barroso, M.; et al. The Influence of the Extraction Temperature on Polyphenolic Profiles and Bioactivity of Chamomile (Matricaria Chamomilla L.) Subcritical Water Extracts. Food Chemistry 2019, 271, 328–337. https://doi.org/10.1016/j.foodchem.2018.07.154. Food Chemistry. 2019;
Cvetanović Aleksandra, Švarc-Gajić Jaroslava, Zeković Zoran P., Jerković Jelena, Zengin Gokhan, Gašić Uroš M., Tešić Živoslav Lj., Mašković Pavle, Soares Cristina, Fatima Barroso M., Delerue-Matos Cristina, Đurović Saša, "Supplementary material for the article: Cvetanovic, A.; Svarc-Gajic, J.; Zekovic, Z.; Jerkovic, J.; Zengin, G.; Gašić, U. M.; Tešić, Ž. L.; Maskovic, P.; Soares, C.; Fatima Barroso, M.; et al. The Influence of the Extraction Temperature on Polyphenolic Profiles and Bioactivity of Chamomile (Matricaria Chamomilla L.) Subcritical Water Extracts. Food Chemistry 2019, 271, 328–337. https://doi.org/10.1016/j.foodchem.2018.07.154" Food Chemistry (2019)

The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts

Cvetanović, Aleksandra; Švarc-Gajić, Jaroslava; Zeković, Zoran P.; Jerković, Jelena; Zengin, Gokhan; Gašić, Uroš M.; Tešić, Živoslav Lj.; Mašković, Pavle; Soares, Cristina; Fatima Barroso, M.; Delerue-Matos, Cristina; Đurović, Saša

(Elsevier Sci Ltd, Oxford, 2019)

TY  - JOUR
AU  - Cvetanović, Aleksandra
AU  - Švarc-Gajić, Jaroslava
AU  - Zeković, Zoran P.
AU  - Jerković, Jelena
AU  - Zengin, Gokhan
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Mašković, Pavle
AU  - Soares, Cristina
AU  - Fatima Barroso, M.
AU  - Delerue-Matos, Cristina
AU  - Đurović, Saša
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2220
AB  - The main goal of this research was to determine the relationship among chemical structure, bioactivity and temperature of chamomile during subcritical water extraction in isobaric conditions (45 bar) at seven different temperatures (65-210 degrees C). The influence of temperature on phenolic profiles was defined by UHPLC-HESI-MS/MS. The overall results indicate that the presence of conjugated double bonds, side chains, glucose moiety or ether moiety in molecules influence the efficiency of polyphenols' extraction in subcritical water. In terms of antioxidant activity, the extracts were the most active towards ABTS radicals (IC50 = 7.3-16.8 mu g/mL), whereby temperature of 150 degrees C was optimal. On the other hand, the extracts obtained at 115 degrees C showed highest cytotoxicity. Inhibition of alpha-amylase and alpha-glucosidase was the highest at 65 and 85 degrees C, i.e. 0.51 and 4.13 mmolAE/g, respectively. Activity against tyrosinase was the highest at 210 degrees C (17.92 mgKAE/g). The data showed that different non-phenolic compounds may also participate in bio-activities of the extracts.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts
VL  - 271
SP  - 328
EP  - 337
DO  - 10.1016/j.foodchem.2018.07.154
ER  - 
@article{
author = "Cvetanović, Aleksandra and Švarc-Gajić, Jaroslava and Zeković, Zoran P. and Jerković, Jelena and Zengin, Gokhan and Gašić, Uroš M. and Tešić, Živoslav Lj. and Mašković, Pavle and Soares, Cristina and Fatima Barroso, M. and Delerue-Matos, Cristina and Đurović, Saša",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2220",
abstract = "The main goal of this research was to determine the relationship among chemical structure, bioactivity and temperature of chamomile during subcritical water extraction in isobaric conditions (45 bar) at seven different temperatures (65-210 degrees C). The influence of temperature on phenolic profiles was defined by UHPLC-HESI-MS/MS. The overall results indicate that the presence of conjugated double bonds, side chains, glucose moiety or ether moiety in molecules influence the efficiency of polyphenols' extraction in subcritical water. In terms of antioxidant activity, the extracts were the most active towards ABTS radicals (IC50 = 7.3-16.8 mu g/mL), whereby temperature of 150 degrees C was optimal. On the other hand, the extracts obtained at 115 degrees C showed highest cytotoxicity. Inhibition of alpha-amylase and alpha-glucosidase was the highest at 65 and 85 degrees C, i.e. 0.51 and 4.13 mmolAE/g, respectively. Activity against tyrosinase was the highest at 210 degrees C (17.92 mgKAE/g). The data showed that different non-phenolic compounds may also participate in bio-activities of the extracts.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts",
volume = "271",
pages = "328-337",
doi = "10.1016/j.foodchem.2018.07.154"
}
Cvetanović, A., Švarc-Gajić, J., Zeković, Z. P., Jerković, J., Zengin, G., Gašić, U. M., Tešić, Ž. Lj., Mašković, P., Soares, C., Fatima Barroso, M., Delerue-Matos, C.,& Đurović, S. (2019). The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts.
Food Chemistry
Elsevier Sci Ltd, Oxford., 271, 328-337.
https://doi.org/10.1016/j.foodchem.2018.07.154
Cvetanović A, Švarc-Gajić J, Zeković ZP, Jerković J, Zengin G, Gašić UM, Tešić ŽL, Mašković P, Soares C, Fatima Barroso M, Delerue-Matos C, Đurović S. The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts. Food Chemistry. 2019;271:328-337
Cvetanović Aleksandra, Švarc-Gajić Jaroslava, Zeković Zoran P., Jerković Jelena, Zengin Gokhan, Gašić Uroš M., Tešić Živoslav Lj., Mašković Pavle, Soares Cristina, Fatima Barroso M., Delerue-Matos Cristina, Đurović Saša, "The influence of the extraction temperature on polyphenolic profiles and bioactivity of chamomile (Matricaria chamomilla L.) subcritical water extracts" Food Chemistry, 271 (2019):328-337,
https://doi.org/10.1016/j.foodchem.2018.07.154 .
1
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24

Subcritical water extraction as a cutting edge technology for the extraction of bioactive compounds from chamomile: Influence of pressure on chemical composition and bioactivity of extracts

Cvetanović, Aleksandra; Švarc-Gajić, Jaroslava; Zeković, Zoran P.; Gašić, Uroš M.; Tešić, Živoslav Lj.; Zengin, Gokhan; Mašković, Pavle; Mahomoodally, Mohamad Fawzi; Đurović, Saša

(Elsevier Sci Ltd, Oxford, 2018)

TY  - JOUR
AU  - Cvetanović, Aleksandra
AU  - Švarc-Gajić, Jaroslava
AU  - Zeković, Zoran P.
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Zengin, Gokhan
AU  - Mašković, Pavle
AU  - Mahomoodally, Mohamad Fawzi
AU  - Đurović, Saša
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2173
AB  - The study was designed to determine the relationship between chemical structure, bioactivity and pressure during the subcritical water extraction (SCW) of chamomile. Extraction was carried out at isothermal conditions (100 degrees C) at five different pressures (10, 30, 45, 60 and 90 bar). Twenty three polyphenolic compounds were identified in the extracts, whereby apigenin was found to be the dominant compound (61.53-1344.99 mg/kg). Results suggest that the lowest applied pressure has negligible effect on phenolic recovery from chamomile, but also the use of pressures above than 45 bar was proven as needlessly. By using in vitro assays, influence of pressure on antioxidant, cytotoxic and enzyme-inhibitory activities of the extracts was evaluated. Extracts obtained at 30, 45 and 60 bar exhibited stronger bioactivities than at 10 and 90 bar. It was concluded that pressure exert a significant influence on chemical composition of extracts, and thus on biological activity of chamomile extracts.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Subcritical water extraction as a cutting edge technology for the extraction of bioactive compounds from chamomile: Influence of pressure on chemical composition and bioactivity of extracts
VL  - 266
SP  - 389
EP  - 396
DO  - 10.1016/j.foodchem.2018.06.037
ER  - 
@article{
author = "Cvetanović, Aleksandra and Švarc-Gajić, Jaroslava and Zeković, Zoran P. and Gašić, Uroš M. and Tešić, Živoslav Lj. and Zengin, Gokhan and Mašković, Pavle and Mahomoodally, Mohamad Fawzi and Đurović, Saša",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2173",
abstract = "The study was designed to determine the relationship between chemical structure, bioactivity and pressure during the subcritical water extraction (SCW) of chamomile. Extraction was carried out at isothermal conditions (100 degrees C) at five different pressures (10, 30, 45, 60 and 90 bar). Twenty three polyphenolic compounds were identified in the extracts, whereby apigenin was found to be the dominant compound (61.53-1344.99 mg/kg). Results suggest that the lowest applied pressure has negligible effect on phenolic recovery from chamomile, but also the use of pressures above than 45 bar was proven as needlessly. By using in vitro assays, influence of pressure on antioxidant, cytotoxic and enzyme-inhibitory activities of the extracts was evaluated. Extracts obtained at 30, 45 and 60 bar exhibited stronger bioactivities than at 10 and 90 bar. It was concluded that pressure exert a significant influence on chemical composition of extracts, and thus on biological activity of chamomile extracts.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Subcritical water extraction as a cutting edge technology for the extraction of bioactive compounds from chamomile: Influence of pressure on chemical composition and bioactivity of extracts",
volume = "266",
pages = "389-396",
doi = "10.1016/j.foodchem.2018.06.037"
}
Cvetanović, A., Švarc-Gajić, J., Zeković, Z. P., Gašić, U. M., Tešić, Ž. Lj., Zengin, G., Mašković, P., Mahomoodally, M. F.,& Đurović, S. (2018). Subcritical water extraction as a cutting edge technology for the extraction of bioactive compounds from chamomile: Influence of pressure on chemical composition and bioactivity of extracts.
Food Chemistry
Elsevier Sci Ltd, Oxford., 266, 389-396.
https://doi.org/10.1016/j.foodchem.2018.06.037
Cvetanović A, Švarc-Gajić J, Zeković ZP, Gašić UM, Tešić ŽL, Zengin G, Mašković P, Mahomoodally MF, Đurović S. Subcritical water extraction as a cutting edge technology for the extraction of bioactive compounds from chamomile: Influence of pressure on chemical composition and bioactivity of extracts. Food Chemistry. 2018;266:389-396
Cvetanović Aleksandra, Švarc-Gajić Jaroslava, Zeković Zoran P., Gašić Uroš M., Tešić Živoslav Lj., Zengin Gokhan, Mašković Pavle, Mahomoodally Mohamad Fawzi, Đurović Saša, "Subcritical water extraction as a cutting edge technology for the extraction of bioactive compounds from chamomile: Influence of pressure on chemical composition and bioactivity of extracts" Food Chemistry, 266 (2018):389-396,
https://doi.org/10.1016/j.foodchem.2018.06.037 .
28
20
22

Isolation of apigenin from subcritical water extracts: Optimization of the process

Cvetanović, Aleksandra; Švarc-Gajić, Jaroslava; Gašić, Uroš M.; Tešić, Živoslav Lj.; Zengin, Gokhan; Zeković, Zoran P.; Đurović, Saša

(Elsevier Science Bv, Amsterdam, 2017)

TY  - JOUR
AU  - Cvetanović, Aleksandra
AU  - Švarc-Gajić, Jaroslava
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Zengin, Gokhan
AU  - Zeković, Zoran P.
AU  - Đurović, Saša
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3137
AB  - Apigenin is a phytochemical which has been associated with numerous beneficial health effects. However, due to its low concentration and poor bioavailability, isolation from natural sources is very difficult. Subcritical water (SCW) is an excellent solvent for the extraction of moderately polar and non-polar flavonoids. Carefully balanced moderate hydrolytical potential of SCW was used in this work to liberate apigenin from its bound forms. In this research simultaneous extraction and hydrolysis of apigenin bound forms from chamomile have been performed. Optimal operation parameters for maximum yields of apigenin have been investigated and defined (solvent-to-sample ratio 1:30; agitation rate 3 Hz; pressure 45 bar; temperature 115 degrees C; time 30 min). Apigenin was further isolated in its pure form from water extracts obtained under optimal conditions using column chromatography. The purity of isolated compound was confirmed by spectroscopic analysis. Biological activity of extracts obtained under optimal conditions were determined as well. In order to identify polyphenolic compounds UHPLC-HESI-MS/MS analysis was performed.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Supercritical Fluids
T1  - Isolation of apigenin from subcritical water extracts: Optimization of the process
VL  - 120
SP  - 32
EP  - 42
DO  - 10.1016/j.supflu.2016.10.012
ER  - 
@article{
author = "Cvetanović, Aleksandra and Švarc-Gajić, Jaroslava and Gašić, Uroš M. and Tešić, Živoslav Lj. and Zengin, Gokhan and Zeković, Zoran P. and Đurović, Saša",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3137",
abstract = "Apigenin is a phytochemical which has been associated with numerous beneficial health effects. However, due to its low concentration and poor bioavailability, isolation from natural sources is very difficult. Subcritical water (SCW) is an excellent solvent for the extraction of moderately polar and non-polar flavonoids. Carefully balanced moderate hydrolytical potential of SCW was used in this work to liberate apigenin from its bound forms. In this research simultaneous extraction and hydrolysis of apigenin bound forms from chamomile have been performed. Optimal operation parameters for maximum yields of apigenin have been investigated and defined (solvent-to-sample ratio 1:30; agitation rate 3 Hz; pressure 45 bar; temperature 115 degrees C; time 30 min). Apigenin was further isolated in its pure form from water extracts obtained under optimal conditions using column chromatography. The purity of isolated compound was confirmed by spectroscopic analysis. Biological activity of extracts obtained under optimal conditions were determined as well. In order to identify polyphenolic compounds UHPLC-HESI-MS/MS analysis was performed.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Supercritical Fluids",
title = "Isolation of apigenin from subcritical water extracts: Optimization of the process",
volume = "120",
pages = "32-42",
doi = "10.1016/j.supflu.2016.10.012"
}
Cvetanović, A., Švarc-Gajić, J., Gašić, U. M., Tešić, Ž. Lj., Zengin, G., Zeković, Z. P.,& Đurović, S. (2017). Isolation of apigenin from subcritical water extracts: Optimization of the process.
Journal of Supercritical Fluids
Elsevier Science Bv, Amsterdam., 120, 32-42.
https://doi.org/10.1016/j.supflu.2016.10.012
Cvetanović A, Švarc-Gajić J, Gašić UM, Tešić ŽL, Zengin G, Zeković ZP, Đurović S. Isolation of apigenin from subcritical water extracts: Optimization of the process. Journal of Supercritical Fluids. 2017;120:32-42
Cvetanović Aleksandra, Švarc-Gajić Jaroslava, Gašić Uroš M., Tešić Živoslav Lj., Zengin Gokhan, Zeković Zoran P., Đurović Saša, "Isolation of apigenin from subcritical water extracts: Optimization of the process" Journal of Supercritical Fluids, 120 (2017):32-42,
https://doi.org/10.1016/j.supflu.2016.10.012 .
47
40
42

Isolation of apigenin from subcritical water extracts: Optimization of the process

Cvetanović, Aleksandra; Švarc-Gajić, Jaroslava; Gašić, Uroš M.; Tešić, Živoslav Lj.; Zengin, Gokhan; Zeković, Zoran P.; Đurović, Saša

(Elsevier Science Bv, Amsterdam, 2017)

TY  - JOUR
AU  - Cvetanović, Aleksandra
AU  - Švarc-Gajić, Jaroslava
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav Lj.
AU  - Zengin, Gokhan
AU  - Zeković, Zoran P.
AU  - Đurović, Saša
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2376
AB  - Apigenin is a phytochemical which has been associated with numerous beneficial health effects. However, due to its low concentration and poor bioavailability, isolation from natural sources is very difficult. Subcritical water (SCW) is an excellent solvent for the extraction of moderately polar and non-polar flavonoids. Carefully balanced moderate hydrolytical potential of SCW was used in this work to liberate apigenin from its bound forms. In this research simultaneous extraction and hydrolysis of apigenin bound forms from chamomile have been performed. Optimal operation parameters for maximum yields of apigenin have been investigated and defined (solvent-to-sample ratio 1:30; agitation rate 3 Hz; pressure 45 bar; temperature 115 degrees C; time 30 min). Apigenin was further isolated in its pure form from water extracts obtained under optimal conditions using column chromatography. The purity of isolated compound was confirmed by spectroscopic analysis. Biological activity of extracts obtained under optimal conditions were determined as well. In order to identify polyphenolic compounds UHPLC-HESI-MS/MS analysis was performed.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Supercritical Fluids
T1  - Isolation of apigenin from subcritical water extracts: Optimization of the process
VL  - 120
SP  - 32
EP  - 42
DO  - 10.1016/j.supflu.2016.10.012
ER  - 
@article{
author = "Cvetanović, Aleksandra and Švarc-Gajić, Jaroslava and Gašić, Uroš M. and Tešić, Živoslav Lj. and Zengin, Gokhan and Zeković, Zoran P. and Đurović, Saša",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2376",
abstract = "Apigenin is a phytochemical which has been associated with numerous beneficial health effects. However, due to its low concentration and poor bioavailability, isolation from natural sources is very difficult. Subcritical water (SCW) is an excellent solvent for the extraction of moderately polar and non-polar flavonoids. Carefully balanced moderate hydrolytical potential of SCW was used in this work to liberate apigenin from its bound forms. In this research simultaneous extraction and hydrolysis of apigenin bound forms from chamomile have been performed. Optimal operation parameters for maximum yields of apigenin have been investigated and defined (solvent-to-sample ratio 1:30; agitation rate 3 Hz; pressure 45 bar; temperature 115 degrees C; time 30 min). Apigenin was further isolated in its pure form from water extracts obtained under optimal conditions using column chromatography. The purity of isolated compound was confirmed by spectroscopic analysis. Biological activity of extracts obtained under optimal conditions were determined as well. In order to identify polyphenolic compounds UHPLC-HESI-MS/MS analysis was performed.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Supercritical Fluids",
title = "Isolation of apigenin from subcritical water extracts: Optimization of the process",
volume = "120",
pages = "32-42",
doi = "10.1016/j.supflu.2016.10.012"
}
Cvetanović, A., Švarc-Gajić, J., Gašić, U. M., Tešić, Ž. Lj., Zengin, G., Zeković, Z. P.,& Đurović, S. (2017). Isolation of apigenin from subcritical water extracts: Optimization of the process.
Journal of Supercritical Fluids
Elsevier Science Bv, Amsterdam., 120, 32-42.
https://doi.org/10.1016/j.supflu.2016.10.012
Cvetanović A, Švarc-Gajić J, Gašić UM, Tešić ŽL, Zengin G, Zeković ZP, Đurović S. Isolation of apigenin from subcritical water extracts: Optimization of the process. Journal of Supercritical Fluids. 2017;120:32-42
Cvetanović Aleksandra, Švarc-Gajić Jaroslava, Gašić Uroš M., Tešić Živoslav Lj., Zengin Gokhan, Zeković Zoran P., Đurović Saša, "Isolation of apigenin from subcritical water extracts: Optimization of the process" Journal of Supercritical Fluids, 120 (2017):32-42,
https://doi.org/10.1016/j.supflu.2016.10.012 .
47
40
42