TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Mančić, Lidija
AU  - Vuković, Marina
AU  - Stojanović, Zoran
AU  - Nikolić, Marko G.
AU  - Škapin, Srečo
AU  - Jovanović, Sonja
AU  - Veselinović, Ljiljana M.
AU  - Uskoković, Vuk
AU  - Lazić, Snežana
AU  - Marković, Smilja
AU  - Lazarević, Miloš M.
AU  - Uskoković, Dragan P.
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3702
AB  - Taking advantage of the flexibility of the apatite structure, nano- and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE3+ = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at T ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P63/m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca2+ with smaller RE3+ ions at both cation positions. The FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:RE3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λex = 370 nm) due to an increased concentration of defects. The "up"- and the "down"-conversion spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders showed characteristic transitions of Tm3+ and Eu3+, respectively. Furthermore, in contrast to diamagnetic HAp, all HAp:RE3+ powders exhibited paramagnetic behavior. Cell viability tests of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.
PB  - Springer Nature
T2  - Scientific reports
T1  - Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging
VL  - 9
IS  - 1
SP  - 16305
DO  - 10.1038/s41598-019-52885-0
ER  - 

@article{
author = "Ignjatović, Nenad and Mančić, Lidija and Vuković, Marina and Stojanović, Zoran and Nikolić, Marko G. and Škapin, Srečo and Jovanović, Sonja and Veselinović, Ljiljana M. and Uskoković, Vuk and Lazić, Snežana and Marković, Smilja and Lazarević, Miloš M. and Uskoković, Dragan P.",
year = "2019",
abstract = "Taking advantage of the flexibility of the apatite structure, nano- and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE3+ = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at T ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P63/m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca2+ with smaller RE3+ ions at both cation positions. The FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:RE3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λex = 370 nm) due to an increased concentration of defects. The "up"- and the "down"-conversion spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders showed characteristic transitions of Tm3+ and Eu3+, respectively. Furthermore, in contrast to diamagnetic HAp, all HAp:RE3+ powders exhibited paramagnetic behavior. Cell viability tests of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.",
publisher = "Springer Nature",
journal = "Scientific reports",
title = "Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging",
volume = "9",
number = "1",
pages = "16305",
doi = "10.1038/s41598-019-52885-0"
}

Ignjatović, N., Mančić, L., Vuković, M., Stojanović, Z., Nikolić, M. G., Škapin, S., Jovanović, S., Veselinović, L. M., Uskoković, V., Lazić, S., Marković, S., Lazarević, M. M.,& Uskoković, D. P.. (2019). Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging. in Scientific reports
Springer Nature., 9(1), 16305.
https://doi.org/10.1038/s41598-019-52885-0

Ignjatović N, Mančić L, Vuković M, Stojanović Z, Nikolić MG, Škapin S, Jovanović S, Veselinović LM, Uskoković V, Lazić S, Marković S, Lazarević MM, Uskoković DP. Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging. in Scientific reports. 2019;9(1):16305.
doi:10.1038/s41598-019-52885-0 .

Ignjatović, Nenad, Mančić, Lidija, Vuković, Marina, Stojanović, Zoran, Nikolić, Marko G., Škapin, Srečo, Jovanović, Sonja, Veselinović, Ljiljana M., Uskoković, Vuk, Lazić, Snežana, Marković, Smilja, Lazarević, Miloš M., Uskoković, Dragan P., "Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging" in Scientific reports, 9, no. 1 (2019):16305,
https://doi.org/10.1038/s41598-019-52885-0 . .

TY  - CONF
AU  - Ignjatović, Nenad
AU  - Mančić, Lidija
AU  - Vuković, Marina
AU  - Stojanović, Zoran S.
AU  - Nikolić, Marko G.
AU  - Škapin, Srečo
AU  - Jovanović, Sonja
AU  - Veselinović, Ljiljana M.
AU  - Lazić, Snežana
AU  - Marković, Smilja
AU  - Uskoković, Dragan
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5228
AB  - Hydroxyapatite (HAp) has been widely used as bone reconstruction materials due to their similarity to bone tissue. The improvement of HAp properties was achieved by doping its crystal lattice with different ions. Lanthanides, i.e. Rare Earth Elements (RE) are also suitable for doping HAp. The aim of the presented research was to investigate the possibility of creating lumino-magnetic particles of HAp doped with gadolinium (Gd3+) ions and co-doped with ytterbium/thulium (Yb3+/Tm3+) or europium (Eu3+) ions for potential use in multimodal imaging (MI). Pure HAp (Ca5(PO4)3(OH)), magnetic HAp:Gd (Ca4.85Gd0.15(PO4)3(OH)), and lumino-magnetic HAp:Gd/Yb/Tm (Ca4.85Gd0.03Yb0.1Tm0.02(PO4)3(OH)) and HAp:Gd/Eu (Ca4.94Gd0.02Eu0.04(PO4)3(OH)) particles were synthesized using emulsification process and hydrothermal processing. All synthesized particles had an elongated shape and exhibited a paramagnetic behavior. Reduction of the unit cell volume as a result of replacement of Ca2+ ions by ions with a smaller ionic radius (Gd3+, Yb3+, Tm3+, Eu3+) confirmed by using XRD and Rietveld refined plots. The energy band gap values of the synthesized samples range from 4.93 to 3.18 eV and decrease in the following order: HAp:Gd >HAp>HAp:Gd/Eu>HAp:Gd/Yb/Tm. The results of photoluminescence emission spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu particles showed characteristic transitions of Tm3+ and Eu3+, respectively.
PB  - Belgrade : Materials Research Society of Serbia
C3  - Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019
T1  - Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents
SP  - 76
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5228
ER  - 

@conference{
author = "Ignjatović, Nenad and Mančić, Lidija and Vuković, Marina and Stojanović, Zoran S. and Nikolić, Marko G. and Škapin, Srečo and Jovanović, Sonja and Veselinović, Ljiljana M. and Lazić, Snežana and Marković, Smilja and Uskoković, Dragan",
year = "2019",
abstract = "Hydroxyapatite (HAp) has been widely used as bone reconstruction materials due to their similarity to bone tissue. The improvement of HAp properties was achieved by doping its crystal lattice with different ions. Lanthanides, i.e. Rare Earth Elements (RE) are also suitable for doping HAp. The aim of the presented research was to investigate the possibility of creating lumino-magnetic particles of HAp doped with gadolinium (Gd3+) ions and co-doped with ytterbium/thulium (Yb3+/Tm3+) or europium (Eu3+) ions for potential use in multimodal imaging (MI). Pure HAp (Ca5(PO4)3(OH)), magnetic HAp:Gd (Ca4.85Gd0.15(PO4)3(OH)), and lumino-magnetic HAp:Gd/Yb/Tm (Ca4.85Gd0.03Yb0.1Tm0.02(PO4)3(OH)) and HAp:Gd/Eu (Ca4.94Gd0.02Eu0.04(PO4)3(OH)) particles were synthesized using emulsification process and hydrothermal processing. All synthesized particles had an elongated shape and exhibited a paramagnetic behavior. Reduction of the unit cell volume as a result of replacement of Ca2+ ions by ions with a smaller ionic radius (Gd3+, Yb3+, Tm3+, Eu3+) confirmed by using XRD and Rietveld refined plots. The energy band gap values of the synthesized samples range from 4.93 to 3.18 eV and decrease in the following order: HAp:Gd >HAp>HAp:Gd/Eu>HAp:Gd/Yb/Tm. The results of photoluminescence emission spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu particles showed characteristic transitions of Tm3+ and Eu3+, respectively.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019",
title = "Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents",
pages = "76-76",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5228"
}

Ignjatović, N., Mančić, L., Vuković, M., Stojanović, Z. S., Nikolić, M. G., Škapin, S., Jovanović, S., Veselinović, L. M., Lazić, S., Marković, S.,& Uskoković, D.. (2019). Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents. in Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019
Belgrade : Materials Research Society of Serbia., 76-76.
https://hdl.handle.net/21.15107/rcub_cherry_5228

Ignjatović N, Mančić L, Vuković M, Stojanović ZS, Nikolić MG, Škapin S, Jovanović S, Veselinović LM, Lazić S, Marković S, Uskoković D. Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents. in Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019. 2019;:76-76.
https://hdl.handle.net/21.15107/rcub_cherry_5228 .

Ignjatović, Nenad, Mančić, Lidija, Vuković, Marina, Stojanović, Zoran S., Nikolić, Marko G., Škapin, Srečo, Jovanović, Sonja, Veselinović, Ljiljana M., Lazić, Snežana, Marković, Smilja, Uskoković, Dragan, "Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents" in Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019 (2019):76-76,
https://hdl.handle.net/21.15107/rcub_cherry_5228 .

TY  - JOUR
AU  - Radotić, Ksenija
AU  - Dučić, T.
AU  - Prodanović, Radivoje
AU  - Vujčić, Zoran
AU  - Karadžić, B.
AU  - Jovanović, Sonja
PY  - 2003
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/53
AB  - We studied the soluble peroxidase and superoxid-dismutase activity, peroxidase isoenzyme pattern and metal content in the needles of 2-year-old spruce grown on soils supplemented with cadmium and nickel concentrations from 3 to 30 mg kg-1 and 50 to 500 mg kg-1 respectively. The two metals were applied both separately and simultaneously. The kinetics of metal assimilation and total accumulated quantity depended on the type of treatment. Following metal exposure, an increase in peroxidase activity in the seedlings treated with Cd and Ni/Cd, and in superoxide-dismutase activity during Ni/Cd treatment was observed. A parallel change of peroxidase isoenzyme pattern occurred. There was a good correlation between accumulated metals in needles and enzyme activities. The effect of Cd on the measured parameters was shown to be stronger comparing to the effect of Ni. The results obtained show that peroxidase and superoxide-dismutase activity and peroxidase isoenzyme pattern could be used to evaluate the capacity of one part of the defense system in spruce seedlings to withstand metal stress.
T2  - Jugoslovenska Medicinska Biohemija
T1  - Toxicity of nickel and cadmium in spruce seedlings: Effect of separated and combined treatments on peroxidase and superoxide-dismutase activity
VL  - 22
IS  - 1
SP  - 41
EP  - 52
DO  - 10.2298/JMH0301041R
ER  - 

@article{
author = "Radotić, Ksenija and Dučić, T. and Prodanović, Radivoje and Vujčić, Zoran and Karadžić, B. and Jovanović, Sonja",
year = "2003",
abstract = "We studied the soluble peroxidase and superoxid-dismutase activity, peroxidase isoenzyme pattern and metal content in the needles of 2-year-old spruce grown on soils supplemented with cadmium and nickel concentrations from 3 to 30 mg kg-1 and 50 to 500 mg kg-1 respectively. The two metals were applied both separately and simultaneously. The kinetics of metal assimilation and total accumulated quantity depended on the type of treatment. Following metal exposure, an increase in peroxidase activity in the seedlings treated with Cd and Ni/Cd, and in superoxide-dismutase activity during Ni/Cd treatment was observed. A parallel change of peroxidase isoenzyme pattern occurred. There was a good correlation between accumulated metals in needles and enzyme activities. The effect of Cd on the measured parameters was shown to be stronger comparing to the effect of Ni. The results obtained show that peroxidase and superoxide-dismutase activity and peroxidase isoenzyme pattern could be used to evaluate the capacity of one part of the defense system in spruce seedlings to withstand metal stress.",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Toxicity of nickel and cadmium in spruce seedlings: Effect of separated and combined treatments on peroxidase and superoxide-dismutase activity",
volume = "22",
number = "1",
pages = "41-52",
doi = "10.2298/JMH0301041R"
}

Radotić, K., Dučić, T., Prodanović, R., Vujčić, Z., Karadžić, B.,& Jovanović, S.. (2003). Toxicity of nickel and cadmium in spruce seedlings: Effect of separated and combined treatments on peroxidase and superoxide-dismutase activity. in Jugoslovenska Medicinska Biohemija, 22(1), 41-52.
https://doi.org/10.2298/JMH0301041R

Radotić K, Dučić T, Prodanović R, Vujčić Z, Karadžić B, Jovanović S. Toxicity of nickel and cadmium in spruce seedlings: Effect of separated and combined treatments on peroxidase and superoxide-dismutase activity. in Jugoslovenska Medicinska Biohemija. 2003;22(1):41-52.
doi:10.2298/JMH0301041R .

Radotić, Ksenija, Dučić, T., Prodanović, Radivoje, Vujčić, Zoran, Karadžić, B., Jovanović, Sonja, "Toxicity of nickel and cadmium in spruce seedlings: Effect of separated and combined treatments on peroxidase and superoxide-dismutase activity" in Jugoslovenska Medicinska Biohemija, 22, no. 1 (2003):41-52,
https://doi.org/10.2298/JMH0301041R . .