Radulović, Niko S.

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orcid::0000-0003-1342-7567
  • Radulović, Niko S. (7)
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Author's Bibliography

Supplementary data for article: Ilic-Tomic, T.; Genčić, M. S.; Živković, M. Z.; Vasiljevic, B.; Djokic, L.; Nikodinovic-Runic, J.; Radulović, N. S. Structural Diversity and Possible Functional Roles of Free Fatty Acids of the Novel Soil Isolate Streptomyces Sp. NP10. Applied Microbiology and Biotechnology 2015, 99 (11), 4815–4833. https://doi.org/10.1007/s00253-014-6364-5

Ilić-Tomić, Tatjana; Genčić, Marija S.; Živković, Miodrag V.; Vasiljević, Branka; Đokić, Lidija; Nikodinović-Runić, Jasmina; Radulović, Niko S.

(Springer, New York, 2015)

TY  - DATA
AU  - Ilić-Tomić, Tatjana
AU  - Genčić, Marija S.
AU  - Živković, Miodrag V.
AU  - Vasiljević, Branka
AU  - Đokić, Lidija
AU  - Nikodinović-Runić, Jasmina
AU  - Radulović, Niko S.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3430
PB  - Springer, New York
T2  - Applied Microbiology and Biotechnology
T1  - Supplementary data for article: Ilic-Tomic, T.; Genčić, M. S.; Živković, M. Z.; Vasiljevic, B.; Djokic, L.; Nikodinovic-Runic, J.; Radulović, N. S. Structural Diversity and Possible Functional Roles of Free Fatty Acids of the Novel Soil Isolate Streptomyces Sp. NP10. Applied Microbiology and Biotechnology 2015, 99 (11), 4815–4833. https://doi.org/10.1007/s00253-014-6364-5
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3430
ER  - 
@misc{
author = "Ilić-Tomić, Tatjana and Genčić, Marija S. and Živković, Miodrag V. and Vasiljević, Branka and Đokić, Lidija and Nikodinović-Runić, Jasmina and Radulović, Niko S.",
year = "2015",
publisher = "Springer, New York",
journal = "Applied Microbiology and Biotechnology",
title = "Supplementary data for article: Ilic-Tomic, T.; Genčić, M. S.; Živković, M. Z.; Vasiljevic, B.; Djokic, L.; Nikodinovic-Runic, J.; Radulović, N. S. Structural Diversity and Possible Functional Roles of Free Fatty Acids of the Novel Soil Isolate Streptomyces Sp. NP10. Applied Microbiology and Biotechnology 2015, 99 (11), 4815–4833. https://doi.org/10.1007/s00253-014-6364-5",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3430"
}
Ilić-Tomić, T., Genčić, M. S., Živković, M. V., Vasiljević, B., Đokić, L., Nikodinović-Runić, J.,& Radulović, N. S.. (2015). Supplementary data for article: Ilic-Tomic, T.; Genčić, M. S.; Živković, M. Z.; Vasiljevic, B.; Djokic, L.; Nikodinovic-Runic, J.; Radulović, N. S. Structural Diversity and Possible Functional Roles of Free Fatty Acids of the Novel Soil Isolate Streptomyces Sp. NP10. Applied Microbiology and Biotechnology 2015, 99 (11), 4815–4833. https://doi.org/10.1007/s00253-014-6364-5. in Applied Microbiology and Biotechnology
Springer, New York..
https://hdl.handle.net/21.15107/rcub_cherry_3430
Ilić-Tomić T, Genčić MS, Živković MV, Vasiljević B, Đokić L, Nikodinović-Runić J, Radulović NS. Supplementary data for article: Ilic-Tomic, T.; Genčić, M. S.; Živković, M. Z.; Vasiljevic, B.; Djokic, L.; Nikodinovic-Runic, J.; Radulović, N. S. Structural Diversity and Possible Functional Roles of Free Fatty Acids of the Novel Soil Isolate Streptomyces Sp. NP10. Applied Microbiology and Biotechnology 2015, 99 (11), 4815–4833. https://doi.org/10.1007/s00253-014-6364-5. in Applied Microbiology and Biotechnology. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3430 .
Ilić-Tomić, Tatjana, Genčić, Marija S., Živković, Miodrag V., Vasiljević, Branka, Đokić, Lidija, Nikodinović-Runić, Jasmina, Radulović, Niko S., "Supplementary data for article: Ilic-Tomic, T.; Genčić, M. S.; Živković, M. Z.; Vasiljevic, B.; Djokic, L.; Nikodinovic-Runic, J.; Radulović, N. S. Structural Diversity and Possible Functional Roles of Free Fatty Acids of the Novel Soil Isolate Streptomyces Sp. NP10. Applied Microbiology and Biotechnology 2015, 99 (11), 4815–4833. https://doi.org/10.1007/s00253-014-6364-5" in Applied Microbiology and Biotechnology (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3430 .

Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10

Ilić-Tomić, Tatjana; Genčić, Marija S.; Živković, Miodrag V.; Vasiljević, Branka; Đokić, Lidija; Nikodinović-Runić, Jasmina; Radulović, Niko S.

(Springer, New York, 2015)

TY  - JOUR
AU  - Ilić-Tomić, Tatjana
AU  - Genčić, Marija S.
AU  - Živković, Miodrag V.
AU  - Vasiljević, Branka
AU  - Đokić, Lidija
AU  - Nikodinović-Runić, Jasmina
AU  - Radulović, Niko S.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1713
AB  - Herein, a novel soil bacterium Streptomyces sp. NP10 able to grow outside usual streptomycetes optimum conditions (e.g., at 4 A degrees C, pH 9 and high NaCl concentration), exhibiting atypical hemolytic, DNAse, and cellulolytic activities, is described. This strain produces and excretes into the growth medium large amounts of free long-chain fatty acids (FAs). A concurrent lipidomics study revealed a large structural diversity of FAs with over 50 different n- and branched-chain, (un)saturated, and cyclopropane FAs (C-7-C-30) produced by this strain. Two of these, i-17:0cy9-10 and a-18:0cy9-10, represent new natural products and the first ever identified branched cyclopropane FAs. Both free and bound lipid profiles of Streptomyces sp. NP10 were dominated by saturated branched chain FAs (i-14:0, a-15:0, and i-16:0). Although these free FAs showed only a moderate antimicrobial activity, our results suggest that they could have an ecophysiological role in interspecies signaling with another soil microorganism Pseudomonas aeruginosa. This work represents the first comprehensive report on the structural diversity and complexity of the free FA pool in Streptomyces. A naturally occurring streptomycete, such as Streptomyces sp. NP10, which secretes significant amounts of free long-chain FAs (non-cytotoxic) into the medium, could be useful in microbial biodiesel production.
PB  - Springer, New York
T2  - Applied Microbiology and Biotechnology
T1  - Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10
VL  - 99
IS  - 11
SP  - 4815
EP  - 4833
DO  - 10.1007/s00253-014-6364-5
ER  - 
@article{
author = "Ilić-Tomić, Tatjana and Genčić, Marija S. and Živković, Miodrag V. and Vasiljević, Branka and Đokić, Lidija and Nikodinović-Runić, Jasmina and Radulović, Niko S.",
year = "2015",
abstract = "Herein, a novel soil bacterium Streptomyces sp. NP10 able to grow outside usual streptomycetes optimum conditions (e.g., at 4 A degrees C, pH 9 and high NaCl concentration), exhibiting atypical hemolytic, DNAse, and cellulolytic activities, is described. This strain produces and excretes into the growth medium large amounts of free long-chain fatty acids (FAs). A concurrent lipidomics study revealed a large structural diversity of FAs with over 50 different n- and branched-chain, (un)saturated, and cyclopropane FAs (C-7-C-30) produced by this strain. Two of these, i-17:0cy9-10 and a-18:0cy9-10, represent new natural products and the first ever identified branched cyclopropane FAs. Both free and bound lipid profiles of Streptomyces sp. NP10 were dominated by saturated branched chain FAs (i-14:0, a-15:0, and i-16:0). Although these free FAs showed only a moderate antimicrobial activity, our results suggest that they could have an ecophysiological role in interspecies signaling with another soil microorganism Pseudomonas aeruginosa. This work represents the first comprehensive report on the structural diversity and complexity of the free FA pool in Streptomyces. A naturally occurring streptomycete, such as Streptomyces sp. NP10, which secretes significant amounts of free long-chain FAs (non-cytotoxic) into the medium, could be useful in microbial biodiesel production.",
publisher = "Springer, New York",
journal = "Applied Microbiology and Biotechnology",
title = "Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10",
volume = "99",
number = "11",
pages = "4815-4833",
doi = "10.1007/s00253-014-6364-5"
}
Ilić-Tomić, T., Genčić, M. S., Živković, M. V., Vasiljević, B., Đokić, L., Nikodinović-Runić, J.,& Radulović, N. S.. (2015). Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10. in Applied Microbiology and Biotechnology
Springer, New York., 99(11), 4815-4833.
https://doi.org/10.1007/s00253-014-6364-5
Ilić-Tomić T, Genčić MS, Živković MV, Vasiljević B, Đokić L, Nikodinović-Runić J, Radulović NS. Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10. in Applied Microbiology and Biotechnology. 2015;99(11):4815-4833.
doi:10.1007/s00253-014-6364-5 .
Ilić-Tomić, Tatjana, Genčić, Marija S., Živković, Miodrag V., Vasiljević, Branka, Đokić, Lidija, Nikodinović-Runić, Jasmina, Radulović, Niko S., "Structural diversity and possible functional roles of free fatty acids of the novel soil isolate Streptomyces sp NP10" in Applied Microbiology and Biotechnology, 99, no. 11 (2015):4815-4833,
https://doi.org/10.1007/s00253-014-6364-5 . .
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Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing

Kramar, Ana; Ilić-Tomić, Tatjana; Petković, Miloš; Radulović, Niko S.; Kostić, Mirjana M.; Jocic, Dragan; Nikodinović-Runić, Jasmina

(Springer, New York, 2014)

TY  - JOUR
AU  - Kramar, Ana
AU  - Ilić-Tomić, Tatjana
AU  - Petković, Miloš
AU  - Radulović, Niko S.
AU  - Kostić, Mirjana M.
AU  - Jocic, Dragan
AU  - Nikodinović-Runić, Jasmina
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1807
AB  - Renewed demand for incorporation of natural dyes (bio-colorants) in textile industry could be met through biotechnological production of bacterial pigments. Two new Streptomyces strains (NP2 and NP4) were isolated for the remarkable ability to produce diffusible deep blue and deep red pigment into fermentation medium. Crude mycelial extracts of both strains were used as bio-colorants in conventional textile dyeing procedures avoiding downstream purification procedures. The yields of bio-colorants obtained in this way were 62 and 84 mg per g of mycelia for Streptomyces sp. NP2 and Streptomyces sp. NP4, respectively. Through nuclear magnetic resonance analysis of crude extracts before and after dyeing procedures, it was shown that both extracts contained prodigiosin-like family of compounds that exhibited different dyeing capabilities towards different textile fibers. Polyamide and acrylic fibers were colored to the deepest shade, polyester and triacetate fibers to a noticeable, but much lower shade depth, while cotton and cellulosic fibers stained weakly. These results confirmed that crude bacterial extracts had the characteristics similar to those of ionic and disperse dyes, which was consistent with the identified polypyrrolic prodigiosin-like structures.
PB  - Springer, New York
T2  - World Journal of Microbiology and Biotechnology
T1  - Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing
VL  - 30
IS  - 8
SP  - 2231
EP  - 2240
DO  - 10.1007/s11274-014-1644-x
ER  - 
@article{
author = "Kramar, Ana and Ilić-Tomić, Tatjana and Petković, Miloš and Radulović, Niko S. and Kostić, Mirjana M. and Jocic, Dragan and Nikodinović-Runić, Jasmina",
year = "2014",
abstract = "Renewed demand for incorporation of natural dyes (bio-colorants) in textile industry could be met through biotechnological production of bacterial pigments. Two new Streptomyces strains (NP2 and NP4) were isolated for the remarkable ability to produce diffusible deep blue and deep red pigment into fermentation medium. Crude mycelial extracts of both strains were used as bio-colorants in conventional textile dyeing procedures avoiding downstream purification procedures. The yields of bio-colorants obtained in this way were 62 and 84 mg per g of mycelia for Streptomyces sp. NP2 and Streptomyces sp. NP4, respectively. Through nuclear magnetic resonance analysis of crude extracts before and after dyeing procedures, it was shown that both extracts contained prodigiosin-like family of compounds that exhibited different dyeing capabilities towards different textile fibers. Polyamide and acrylic fibers were colored to the deepest shade, polyester and triacetate fibers to a noticeable, but much lower shade depth, while cotton and cellulosic fibers stained weakly. These results confirmed that crude bacterial extracts had the characteristics similar to those of ionic and disperse dyes, which was consistent with the identified polypyrrolic prodigiosin-like structures.",
publisher = "Springer, New York",
journal = "World Journal of Microbiology and Biotechnology",
title = "Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing",
volume = "30",
number = "8",
pages = "2231-2240",
doi = "10.1007/s11274-014-1644-x"
}
Kramar, A., Ilić-Tomić, T., Petković, M., Radulović, N. S., Kostić, M. M., Jocic, D.,& Nikodinović-Runić, J.. (2014). Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing. in World Journal of Microbiology and Biotechnology
Springer, New York., 30(8), 2231-2240.
https://doi.org/10.1007/s11274-014-1644-x
Kramar A, Ilić-Tomić T, Petković M, Radulović NS, Kostić MM, Jocic D, Nikodinović-Runić J. Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing. in World Journal of Microbiology and Biotechnology. 2014;30(8):2231-2240.
doi:10.1007/s11274-014-1644-x .
Kramar, Ana, Ilić-Tomić, Tatjana, Petković, Miloš, Radulović, Niko S., Kostić, Mirjana M., Jocic, Dragan, Nikodinović-Runić, Jasmina, "Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing" in World Journal of Microbiology and Biotechnology, 30, no. 8 (2014):2231-2240,
https://doi.org/10.1007/s11274-014-1644-x . .
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Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy

Radulović, Niko S.; Zlatkovic, Dragan B.; Ilić-Tomić, Tatjana; Šenerović, Lidija; Nikodinović-Runić, Jasmina

(Elsevier Ireland Ltd, Clare, 2014)

TY  - JOUR
AU  - Radulović, Niko S.
AU  - Zlatkovic, Dragan B.
AU  - Ilić-Tomić, Tatjana
AU  - Šenerović, Lidija
AU  - Nikodinović-Runić, Jasmina
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1773
AB  - Ethnopharmacological relevance: Reseda lutea L (Resedaceae) or Wild Mignonette is a widely distributed plant species. Pliny the Elder (AD 23-AD 79), a Roman scholar and naturalist, reported the use of R. lutea for reducing tumors in his Historia naturalis. Accounts of the beneficial effects of R. lutea in tumor treatment could also be found in the works of later authors, such as Etienne Francois Geoffroy (1672-1731) and Samuel Frederick Gray (1766-1828). However, to date no in vivo or in vitro evidence exists in support of the alleged tumor healing properties of R. lutea. Materials and methods: The composition of autolysates obtained from different organs (root, flower and fruit) of R. lutea was investigated by GC and GC-MS analyses and IR, 1D and 2D NMR spectroscopy. These analyses led to the discovery of a new compound isolated in pure form from the flower autolysate. Autolysates and their major constituents were submitted to MU-dye reduction cytotoxic assay on human A375 (melanoma) and MRC5 (fibroblast) cell lines. Mechanism of the cytotoxic effects was studied by cell cycle analysis and Annexin V assay. Results: Benzyl isothiocyanate and 2-(alpha-L-rhamnopyranosyloxy)benzyl isothiocyanate were identified as the major constituents of the root and flower autolysates, respectively (the later represents a new natural product). These compounds showed significant antiproliferative effects against both cell lines, which could also explain the observed high cytotoxic activity of the tested autolysates. Cell cycle analysis revealed apoptosis as the probable mechanism of cell death. Conclusions: Tumor healing properties attributed to R. lutea in the pre-modern texts were substantiated by the herein obtained results. Two isothiocyanates were found to be the major carriers of the observed activity. Although there was a relatively low differential effect of the plant metabolites on transformed and non-transformed cell lines, one can argue that the noted strong cytotoxicity provides first evidence that could explain the long forgotten use of this particular species. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy
VL  - 153
IS  - 1
SP  - 125
EP  - 132
DO  - 10.1016/j.jep.2014.01.034
ER  - 
@article{
author = "Radulović, Niko S. and Zlatkovic, Dragan B. and Ilić-Tomić, Tatjana and Šenerović, Lidija and Nikodinović-Runić, Jasmina",
year = "2014",
abstract = "Ethnopharmacological relevance: Reseda lutea L (Resedaceae) or Wild Mignonette is a widely distributed plant species. Pliny the Elder (AD 23-AD 79), a Roman scholar and naturalist, reported the use of R. lutea for reducing tumors in his Historia naturalis. Accounts of the beneficial effects of R. lutea in tumor treatment could also be found in the works of later authors, such as Etienne Francois Geoffroy (1672-1731) and Samuel Frederick Gray (1766-1828). However, to date no in vivo or in vitro evidence exists in support of the alleged tumor healing properties of R. lutea. Materials and methods: The composition of autolysates obtained from different organs (root, flower and fruit) of R. lutea was investigated by GC and GC-MS analyses and IR, 1D and 2D NMR spectroscopy. These analyses led to the discovery of a new compound isolated in pure form from the flower autolysate. Autolysates and their major constituents were submitted to MU-dye reduction cytotoxic assay on human A375 (melanoma) and MRC5 (fibroblast) cell lines. Mechanism of the cytotoxic effects was studied by cell cycle analysis and Annexin V assay. Results: Benzyl isothiocyanate and 2-(alpha-L-rhamnopyranosyloxy)benzyl isothiocyanate were identified as the major constituents of the root and flower autolysates, respectively (the later represents a new natural product). These compounds showed significant antiproliferative effects against both cell lines, which could also explain the observed high cytotoxic activity of the tested autolysates. Cell cycle analysis revealed apoptosis as the probable mechanism of cell death. Conclusions: Tumor healing properties attributed to R. lutea in the pre-modern texts were substantiated by the herein obtained results. Two isothiocyanates were found to be the major carriers of the observed activity. Although there was a relatively low differential effect of the plant metabolites on transformed and non-transformed cell lines, one can argue that the noted strong cytotoxicity provides first evidence that could explain the long forgotten use of this particular species. (C) 2014 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy",
volume = "153",
number = "1",
pages = "125-132",
doi = "10.1016/j.jep.2014.01.034"
}
Radulović, N. S., Zlatkovic, D. B., Ilić-Tomić, T., Šenerović, L.,& Nikodinović-Runić, J.. (2014). Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare., 153(1), 125-132.
https://doi.org/10.1016/j.jep.2014.01.034
Radulović NS, Zlatkovic DB, Ilić-Tomić T, Šenerović L, Nikodinović-Runić J. Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy. in Journal of Ethnopharmacology. 2014;153(1):125-132.
doi:10.1016/j.jep.2014.01.034 .
Radulović, Niko S., Zlatkovic, Dragan B., Ilić-Tomić, Tatjana, Šenerović, Lidija, Nikodinović-Runić, Jasmina, "Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy" in Journal of Ethnopharmacology, 153, no. 1 (2014):125-132,
https://doi.org/10.1016/j.jep.2014.01.034 . .
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Toxic essential oils. Part III: Identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.)

Radulović, Niko S.; Mladenović, Marko Z.; Blagojević, Polina D.; Stojanovic-Radic, Zorica Z.; Ilić-Tomić, Tatjana; Šenerović, Lidija; Nikodinović-Runić, Jasmina

(Pergamon-Elsevier Science Ltd, Oxford, 2013)

TY  - JOUR
AU  - Radulović, Niko S.
AU  - Mladenović, Marko Z.
AU  - Blagojević, Polina D.
AU  - Stojanovic-Radic, Zorica Z.
AU  - Ilić-Tomić, Tatjana
AU  - Šenerović, Lidija
AU  - Nikodinović-Runić, Jasmina
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1485
AB  - To determine the exact structure of previously tentatively identified minor essential-oil constituents of a Chamomile species (Antemis segetalis Ten. (Asteraceae)), we have synthesized a small combinatorial library of 54 regioisomeric allylmethoxyphenyl pentanoates and 2-pentenoates (49 completely new compounds). GC-MS in combination with 1D- and 2D-NMR analyses of the library compounds provided unambiguous data that led to a straightforward identification of the mentioned A. segetalis constituents as eugenyl angelate, 2-methylbutanoate and 3-methylbutanoate (0.21, 0.22, and 0.13 mg/100 g of fresh plant material, respectively). To assess the safety and potential beneficial pharmacological uses of these naturally occurring esters and several other library compounds (these were tested to provide relevant data for a SAR (structure-activity relationship) analysis), we have studied the effect of these compounds in several models of toxicity (acute toxicity against Artemia sauna, cytotoxicity against two cell lines (fibroblast and melanoma)), as well as their acetylcholinesterase inhibitory and antibacterial activities. Anthemis segetalis constituents showed low to moderate activity in all tests. The obtained results suggest that the intake of these compounds in naturally available amounts, on their own, would probably not represent a risk to human health but the possible adverse interactions with the plant matrix should not be neglected.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Toxic essential oils. Part III: Identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.)
VL  - 62
SP  - 554
EP  - 565
DO  - 10.1016/j.fct.2013.09.017
ER  - 
@article{
author = "Radulović, Niko S. and Mladenović, Marko Z. and Blagojević, Polina D. and Stojanovic-Radic, Zorica Z. and Ilić-Tomić, Tatjana and Šenerović, Lidija and Nikodinović-Runić, Jasmina",
year = "2013",
abstract = "To determine the exact structure of previously tentatively identified minor essential-oil constituents of a Chamomile species (Antemis segetalis Ten. (Asteraceae)), we have synthesized a small combinatorial library of 54 regioisomeric allylmethoxyphenyl pentanoates and 2-pentenoates (49 completely new compounds). GC-MS in combination with 1D- and 2D-NMR analyses of the library compounds provided unambiguous data that led to a straightforward identification of the mentioned A. segetalis constituents as eugenyl angelate, 2-methylbutanoate and 3-methylbutanoate (0.21, 0.22, and 0.13 mg/100 g of fresh plant material, respectively). To assess the safety and potential beneficial pharmacological uses of these naturally occurring esters and several other library compounds (these were tested to provide relevant data for a SAR (structure-activity relationship) analysis), we have studied the effect of these compounds in several models of toxicity (acute toxicity against Artemia sauna, cytotoxicity against two cell lines (fibroblast and melanoma)), as well as their acetylcholinesterase inhibitory and antibacterial activities. Anthemis segetalis constituents showed low to moderate activity in all tests. The obtained results suggest that the intake of these compounds in naturally available amounts, on their own, would probably not represent a risk to human health but the possible adverse interactions with the plant matrix should not be neglected.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Toxic essential oils. Part III: Identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.)",
volume = "62",
pages = "554-565",
doi = "10.1016/j.fct.2013.09.017"
}
Radulović, N. S., Mladenović, M. Z., Blagojević, P. D., Stojanovic-Radic, Z. Z., Ilić-Tomić, T., Šenerović, L.,& Nikodinović-Runić, J.. (2013). Toxic essential oils. Part III: Identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.). in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 62, 554-565.
https://doi.org/10.1016/j.fct.2013.09.017
Radulović NS, Mladenović MZ, Blagojević PD, Stojanovic-Radic ZZ, Ilić-Tomić T, Šenerović L, Nikodinović-Runić J. Toxic essential oils. Part III: Identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.). in Food and Chemical Toxicology. 2013;62:554-565.
doi:10.1016/j.fct.2013.09.017 .
Radulović, Niko S., Mladenović, Marko Z., Blagojević, Polina D., Stojanovic-Radic, Zorica Z., Ilić-Tomić, Tatjana, Šenerović, Lidija, Nikodinović-Runić, Jasmina, "Toxic essential oils. Part III: Identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.)" in Food and Chemical Toxicology, 62 (2013):554-565,
https://doi.org/10.1016/j.fct.2013.09.017 . .
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Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety

Ratkovic, Zoran; Juranić, Zorica D.; Stanojković, Tatjana; Manojlović, Dragan D.; Vukicevic, Rastko D.; Radulović, Niko S.; Joksović, Milan D.

(Academic Press Inc Elsevier Science, San Diego, 2010)

TY  - JOUR
AU  - Ratkovic, Zoran
AU  - Juranić, Zorica D.
AU  - Stanojković, Tatjana
AU  - Manojlović, Dragan D.
AU  - Vukicevic, Rastko D.
AU  - Radulović, Niko S.
AU  - Joksović, Milan D.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1078
AB  - A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Bioorganic Chemistry
T1  - Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety
VL  - 38
IS  - 1-3
SP  - 26
EP  - 32
DO  - 10.1016/j.bioorg.2009.09.003
ER  - 
@article{
author = "Ratkovic, Zoran and Juranić, Zorica D. and Stanojković, Tatjana and Manojlović, Dragan D. and Vukicevic, Rastko D. and Radulović, Niko S. and Joksović, Milan D.",
year = "2010",
abstract = "A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Bioorganic Chemistry",
title = "Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety",
volume = "38",
number = "1-3",
pages = "26-32",
doi = "10.1016/j.bioorg.2009.09.003"
}
Ratkovic, Z., Juranić, Z. D., Stanojković, T., Manojlović, D. D., Vukicevic, R. D., Radulović, N. S.,& Joksović, M. D.. (2010). Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety. in Bioorganic Chemistry
Academic Press Inc Elsevier Science, San Diego., 38(1-3), 26-32.
https://doi.org/10.1016/j.bioorg.2009.09.003
Ratkovic Z, Juranić ZD, Stanojković T, Manojlović DD, Vukicevic RD, Radulović NS, Joksović MD. Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety. in Bioorganic Chemistry. 2010;38(1-3):26-32.
doi:10.1016/j.bioorg.2009.09.003 .
Ratkovic, Zoran, Juranić, Zorica D., Stanojković, Tatjana, Manojlović, Dragan D., Vukicevic, Rastko D., Radulović, Niko S., Joksović, Milan D., "Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety" in Bioorganic Chemistry, 38, no. 1-3 (2010):26-32,
https://doi.org/10.1016/j.bioorg.2009.09.003 . .
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Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes

Damljanovic, Ivan; Colovic, Marija; Vukicevic, Mirjana; Manojlović, Dragan D.; Radulović, Niko S.; Wurst, Klaus; Laus, Gerhard; Ratkovic, Zoran; Joksović, Milan D.; Vukicevic, Rastko D.

(Elsevier Science Sa, Lausanne, 2009)

TY  - JOUR
AU  - Damljanovic, Ivan
AU  - Colovic, Marija
AU  - Vukicevic, Mirjana
AU  - Manojlović, Dragan D.
AU  - Radulović, Niko S.
AU  - Wurst, Klaus
AU  - Laus, Gerhard
AU  - Ratkovic, Zoran
AU  - Joksović, Milan D.
AU  - Vukicevic, Rastko D.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/618
AB  - New ferrocene derivatives - 1H-1-phenylpyrazole-4-carboxaldehydes containing o-, m- and p- ferrocenylphenyl group at position 3 - were synthesized and characterized. The electrochemical investigation showed that the position of the ferrocenyl group does not affect the redox potential of these compounds. The X-ray crystal structure of the ortho-derivative is also presented. The screening for the in vitro antimicrobial activity against eleven bacterial and three fungal/yeast strains exhibited complete inactivity of these aldehydes, but n-butyl imines of ortho and meta derivatives showed moderate activity compared to those of the used standards. (C) 2009 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes
VL  - 694
IS  - 9-10
SP  - 1575
EP  - 1580
DO  - 10.1016/j.jorganchem.2009.01.045
ER  - 
@article{
author = "Damljanovic, Ivan and Colovic, Marija and Vukicevic, Mirjana and Manojlović, Dragan D. and Radulović, Niko S. and Wurst, Klaus and Laus, Gerhard and Ratkovic, Zoran and Joksović, Milan D. and Vukicevic, Rastko D.",
year = "2009",
abstract = "New ferrocene derivatives - 1H-1-phenylpyrazole-4-carboxaldehydes containing o-, m- and p- ferrocenylphenyl group at position 3 - were synthesized and characterized. The electrochemical investigation showed that the position of the ferrocenyl group does not affect the redox potential of these compounds. The X-ray crystal structure of the ortho-derivative is also presented. The screening for the in vitro antimicrobial activity against eleven bacterial and three fungal/yeast strains exhibited complete inactivity of these aldehydes, but n-butyl imines of ortho and meta derivatives showed moderate activity compared to those of the used standards. (C) 2009 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes",
volume = "694",
number = "9-10",
pages = "1575-1580",
doi = "10.1016/j.jorganchem.2009.01.045"
}
Damljanovic, I., Colovic, M., Vukicevic, M., Manojlović, D. D., Radulović, N. S., Wurst, K., Laus, G., Ratkovic, Z., Joksović, M. D.,& Vukicevic, R. D.. (2009). Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes. in Journal of Organometallic Chemistry
Elsevier Science Sa, Lausanne., 694(9-10), 1575-1580.
https://doi.org/10.1016/j.jorganchem.2009.01.045
Damljanovic I, Colovic M, Vukicevic M, Manojlović DD, Radulović NS, Wurst K, Laus G, Ratkovic Z, Joksović MD, Vukicevic RD. Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes. in Journal of Organometallic Chemistry. 2009;694(9-10):1575-1580.
doi:10.1016/j.jorganchem.2009.01.045 .
Damljanovic, Ivan, Colovic, Marija, Vukicevic, Mirjana, Manojlović, Dragan D., Radulović, Niko S., Wurst, Klaus, Laus, Gerhard, Ratkovic, Zoran, Joksović, Milan D., Vukicevic, Rastko D., "Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes" in Journal of Organometallic Chemistry, 694, no. 9-10 (2009):1575-1580,
https://doi.org/10.1016/j.jorganchem.2009.01.045 . .
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