TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Trifković, Jelena
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Bogdanović, Gradimir
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2181
AB  - Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism
VL  - 48
SP  - 134
EP  - 140
DO  - 10.1016/j.jtemb.2018.03.020
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Trifković, Jelena and Rašić-Milutinović, Zorica and Jovanović, Dragana and Bogdanović, Gradimir and Mutić, Jelena and Manojlović, Dragan D.",
year = "2018",
abstract = "Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism",
volume = "48",
pages = "134-140",
doi = "10.1016/j.jtemb.2018.03.020"
}

Stojsavljević, A., Trifković, J., Rašić-Milutinović, Z., Jovanović, D., Bogdanović, G., Mutić, J.,& Manojlović, D. D.. (2018). Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. in Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 48, 134-140.
https://doi.org/10.1016/j.jtemb.2018.03.020

Stojsavljević A, Trifković J, Rašić-Milutinović Z, Jovanović D, Bogdanović G, Mutić J, Manojlović DD. Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. in Journal of Trace Elements in Medicine and Biology. 2018;48:134-140.
doi:10.1016/j.jtemb.2018.03.020 .

Stojsavljević, Aleksandar, Trifković, Jelena, Rašić-Milutinović, Zorica, Jovanović, Dragana, Bogdanović, Gradimir, Mutić, Jelena, Manojlović, Dragan D., "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism" in Journal of Trace Elements in Medicine and Biology, 48 (2018):134-140,
https://doi.org/10.1016/j.jtemb.2018.03.020 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Trifković, Jelena
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Bogdanović, Gradimir
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3074
AB  - Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism
VL  - 48
SP  - 134
EP  - 140
DO  - 10.1016/j.jtemb.2018.03.020
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Trifković, Jelena and Rašić-Milutinović, Zorica and Jovanović, Dragana and Bogdanović, Gradimir and Mutić, Jelena and Manojlović, Dragan D.",
year = "2018",
abstract = "Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism",
volume = "48",
pages = "134-140",
doi = "10.1016/j.jtemb.2018.03.020"
}

Stojsavljević, A., Trifković, J., Rašić-Milutinović, Z., Jovanović, D., Bogdanović, G., Mutić, J.,& Manojlović, D. D.. (2018). Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. in Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 48, 134-140.
https://doi.org/10.1016/j.jtemb.2018.03.020

Stojsavljević A, Trifković J, Rašić-Milutinović Z, Jovanović D, Bogdanović G, Mutić J, Manojlović DD. Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. in Journal of Trace Elements in Medicine and Biology. 2018;48:134-140.
doi:10.1016/j.jtemb.2018.03.020 .

Stojsavljević, Aleksandar, Trifković, Jelena, Rašić-Milutinović, Zorica, Jovanović, Dragana, Bogdanović, Gradimir, Mutić, Jelena, Manojlović, Dragan D., "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism" in Journal of Trace Elements in Medicine and Biology, 48 (2018):134-140,
https://doi.org/10.1016/j.jtemb.2018.03.020 . .

TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Trifković, Jelena
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Bogdanović, Gradimir
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3075
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3075
ER  - 

@misc{
author = "Stojsavljević, Aleksandar and Trifković, Jelena and Rašić-Milutinović, Zorica and Jovanović, Dragana and Bogdanović, Gradimir and Mutić, Jelena and Manojlović, Dragan D.",
year = "2018",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3075"
}

Stojsavljević, A., Trifković, J., Rašić-Milutinović, Z., Jovanović, D., Bogdanović, G., Mutić, J.,& Manojlović, D. D.. (2018). Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020. in Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Urban & Fischer Verlag, Jena..
https://hdl.handle.net/21.15107/rcub_cherry_3075

Stojsavljević A, Trifković J, Rašić-Milutinović Z, Jovanović D, Bogdanović G, Mutić J, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020. in Journal of Trace Elements in Medicine and Biology. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3075 .

Stojsavljević, Aleksandar, Trifković, Jelena, Rašić-Milutinović, Zorica, Jovanović, Dragana, Bogdanović, Gradimir, Mutić, Jelena, Manojlović, Dragan D., "Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020" in Journal of Trace Elements in Medicine and Biology (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3075 .

TY  - JOUR
AU  - Rašić-Milutinović, Zorica
AU  - Jovanovic, D.
AU  - Bogdanović, G.
AU  - Trifunović, Jelena
AU  - Mutić, Jelena
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2426
AB  - Background: Besides genetic factors, it is known that some trace elements, as Selenium, Copper, and Zinc are essential for thyroid gland fuction and thyroid hormone metabolism. Moreover, there were some metals effect that suggested patterns associated with overt thyroid disease. Aim of study: Hashimoto thyroiditis (HT), chronic autoimune inflamation of thyroid gland with cosequtive hipothyroidism, is common disease in Serbia, and we thought it is worthwile to explore potential effects of essential and toxic metals and metalloides on thyroid function and ability to restore euthyroid status of them. Results: This cross-sectional, case-control, study investigated the status of essential elements (Selenium,Copper,and Zinc) and toxic metals and metalloides (Al, Cr, Mn, Co, As, Cd, Sb, Ba, Be, Pb and Ni) from the blood of 22 female, patients with Hashimoto thyroiditis and overt hypothyroidism, and compared it with those of 55 female healthy persons. We tried to establish the presence of any correlation between previous mentioned elements and thyroid function in hypothyroid patients and healthy participants. Conclusions: The results of our study suggested that the blood concentration of essential trace elements, especially the ratio of Copper, and Selenium may influence directly thyroid function in patients with HT and overt hypothyroidism. Thus, our findings may have implication to life-long substitution therapy in terms of l-thyroxine dose reduction. Furthermore, for the first time, our study shown potential toxic effect of Cadmium on thyroid function in HT patients, which may implicate the dose of l-thyroxine substitution.
PB  - Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart
T2  - Experimental and Clinical Endocrinology and Diabetes
T1  - Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism
VL  - 125
IS  - 2
SP  - 79
EP  - 85
DO  - 10.1055/s-0042-116070
ER  - 

@article{
author = "Rašić-Milutinović, Zorica and Jovanovic, D. and Bogdanović, G. and Trifunović, Jelena and Mutić, Jelena",
year = "2017",
abstract = "Background: Besides genetic factors, it is known that some trace elements, as Selenium, Copper, and Zinc are essential for thyroid gland fuction and thyroid hormone metabolism. Moreover, there were some metals effect that suggested patterns associated with overt thyroid disease. Aim of study: Hashimoto thyroiditis (HT), chronic autoimune inflamation of thyroid gland with cosequtive hipothyroidism, is common disease in Serbia, and we thought it is worthwile to explore potential effects of essential and toxic metals and metalloides on thyroid function and ability to restore euthyroid status of them. Results: This cross-sectional, case-control, study investigated the status of essential elements (Selenium,Copper,and Zinc) and toxic metals and metalloides (Al, Cr, Mn, Co, As, Cd, Sb, Ba, Be, Pb and Ni) from the blood of 22 female, patients with Hashimoto thyroiditis and overt hypothyroidism, and compared it with those of 55 female healthy persons. We tried to establish the presence of any correlation between previous mentioned elements and thyroid function in hypothyroid patients and healthy participants. Conclusions: The results of our study suggested that the blood concentration of essential trace elements, especially the ratio of Copper, and Selenium may influence directly thyroid function in patients with HT and overt hypothyroidism. Thus, our findings may have implication to life-long substitution therapy in terms of l-thyroxine dose reduction. Furthermore, for the first time, our study shown potential toxic effect of Cadmium on thyroid function in HT patients, which may implicate the dose of l-thyroxine substitution.",
publisher = "Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart",
journal = "Experimental and Clinical Endocrinology and Diabetes",
title = "Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism",
volume = "125",
number = "2",
pages = "79-85",
doi = "10.1055/s-0042-116070"
}

Rašić-Milutinović, Z., Jovanovic, D., Bogdanović, G., Trifunović, J.,& Mutić, J.. (2017). Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism. in Experimental and Clinical Endocrinology and Diabetes
Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart., 125(2), 79-85.
https://doi.org/10.1055/s-0042-116070

Rašić-Milutinović Z, Jovanovic D, Bogdanović G, Trifunović J, Mutić J. Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism. in Experimental and Clinical Endocrinology and Diabetes. 2017;125(2):79-85.
doi:10.1055/s-0042-116070 .

Rašić-Milutinović, Zorica, Jovanovic, D., Bogdanović, G., Trifunović, Jelena, Mutić, Jelena, "Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism" in Experimental and Clinical Endocrinology and Diabetes, 125, no. 2 (2017):79-85,
https://doi.org/10.1055/s-0042-116070 . .

TY  - CONF
AU  - Jovanović, Dragana
AU  - Paunović, Katarina
AU  - Manojlović, Dragan D.
AU  - Rašić-Milutinović, Zorica
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/309
AB  - The highest arsenic concentrations in Serbia are measured in drinking water in the Middle Banat region within Vojvodina. The research was designed as a registry-based cross-sectional study comprising two separate populations in Serbia. Mean arsenic concentrations in drinking water from public water supply systems in 383 samples in Middle Banat region was 56.1 μg/L, Median value 38.0 μg/L, range 1.0–349.0 μg/L. This cross-sectional study showed that population from Middle Banat region in Serbia, exposed to low levels of arsenic in drinking water, was at higher risk for the occurrence of type 2 diabetes, in comparison to the unexposed population in Central Serbia. © 2016 Taylor & Francis Group, London.
T1  - Epidemiological evidences on drinking water arsenic and type 2 diabetes
SP  - 376
EP  - 377
UR  - https://hdl.handle.net/21.15107/rcub_cherry_309
ER  - 

@conference{
author = "Jovanović, Dragana and Paunović, Katarina and Manojlović, Dragan D. and Rašić-Milutinović, Zorica",
year = "2016",
abstract = "The highest arsenic concentrations in Serbia are measured in drinking water in the Middle Banat region within Vojvodina. The research was designed as a registry-based cross-sectional study comprising two separate populations in Serbia. Mean arsenic concentrations in drinking water from public water supply systems in 383 samples in Middle Banat region was 56.1 μg/L, Median value 38.0 μg/L, range 1.0–349.0 μg/L. This cross-sectional study showed that population from Middle Banat region in Serbia, exposed to low levels of arsenic in drinking water, was at higher risk for the occurrence of type 2 diabetes, in comparison to the unexposed population in Central Serbia. © 2016 Taylor & Francis Group, London.",
title = "Epidemiological evidences on drinking water arsenic and type 2 diabetes",
pages = "376-377",
url = "https://hdl.handle.net/21.15107/rcub_cherry_309"
}

Jovanović, D., Paunović, K., Manojlović, D. D.,& Rašić-Milutinović, Z.. (2016). Epidemiological evidences on drinking water arsenic and type 2 diabetes. , 376-377.
https://hdl.handle.net/21.15107/rcub_cherry_309

Jovanović D, Paunović K, Manojlović DD, Rašić-Milutinović Z. Epidemiological evidences on drinking water arsenic and type 2 diabetes. 2016;:376-377.
https://hdl.handle.net/21.15107/rcub_cherry_309 .

Jovanović, Dragana, Paunović, Katarina, Manojlović, Dragan D., Rašić-Milutinović, Zorica, "Epidemiological evidences on drinking water arsenic and type 2 diabetes" (2016):376-377,
https://hdl.handle.net/21.15107/rcub_cherry_309 .

TY  - CHAP
AU  - Sudar, Emina
AU  - Soskić, Sanja
AU  - Zarić, Božidarka L.
AU  - Rašić-Milutinović, Zorica
AU  - Smiljanić, Katarina
AU  - Radak, Đorđe
AU  - Mikhailidis, Dimitri
AU  - Rizzo, Manfredi
AU  - Isenović, Esma
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3919
AB  - Cardiovascular disease (CVD) is common cause of death in humans and its major underlying pathology is atherosclerosis. Atherosclerosis is a chronic inflammatory disease that predisposes to coronary artery disease (CAD), stroke and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality. This inflammatory process, triggered by the presence of lipids in the vascular wall, and encompasses a complex interaction among inflammatory cells, vascular elements, and lipoproteins through the expression of several adhesion molecules and cytokines. Obesity is a risk factor for CVD but this association is not fully understood. Altered levels of obesity related peptides such as ghrelin may play an important role in this pathophysiology. Recent evidence indicates that ghrelin features several cardiovascular activities, including increased myocardial contractility, vasodilatation and protection from myocardial infarction. Recent data demonstrate that ghrelin can influence important key events in atherogenesis and thus they may play a role in atherosclerosis. In this review we present the latest data from recent animal and clinical studies which focus on a novel approach to ghrelin as a potential therapeutic agent in the treatment of a complex disease like atherosclerosis. Thus, ghrelin may become a new therapeutic target for the treatment of CVD. Further studies are necessary to investigate the potential mechanisms involved in the effects of ghrelin on the cardiovascular system.
PB  - Nova Science Publishers Inc, New York
T2  - Ghrelin: Production, Action Mechanisms and Physiological Effects
T1  - Ghrelin, obesity and atherosclerosis
SP  - 111
EP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3919
ER  - 

@inbook{
author = "Sudar, Emina and Soskić, Sanja and Zarić, Božidarka L. and Rašić-Milutinović, Zorica and Smiljanić, Katarina and Radak, Đorđe and Mikhailidis, Dimitri and Rizzo, Manfredi and Isenović, Esma",
year = "2012",
abstract = "Cardiovascular disease (CVD) is common cause of death in humans and its major underlying pathology is atherosclerosis. Atherosclerosis is a chronic inflammatory disease that predisposes to coronary artery disease (CAD), stroke and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality. This inflammatory process, triggered by the presence of lipids in the vascular wall, and encompasses a complex interaction among inflammatory cells, vascular elements, and lipoproteins through the expression of several adhesion molecules and cytokines. Obesity is a risk factor for CVD but this association is not fully understood. Altered levels of obesity related peptides such as ghrelin may play an important role in this pathophysiology. Recent evidence indicates that ghrelin features several cardiovascular activities, including increased myocardial contractility, vasodilatation and protection from myocardial infarction. Recent data demonstrate that ghrelin can influence important key events in atherogenesis and thus they may play a role in atherosclerosis. In this review we present the latest data from recent animal and clinical studies which focus on a novel approach to ghrelin as a potential therapeutic agent in the treatment of a complex disease like atherosclerosis. Thus, ghrelin may become a new therapeutic target for the treatment of CVD. Further studies are necessary to investigate the potential mechanisms involved in the effects of ghrelin on the cardiovascular system.",
publisher = "Nova Science Publishers Inc, New York",
journal = "Ghrelin: Production, Action Mechanisms and Physiological Effects",
booktitle = "Ghrelin, obesity and atherosclerosis",
pages = "111-126",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3919"
}

Sudar, E., Soskić, S., Zarić, B. L., Rašić-Milutinović, Z., Smiljanić, K., Radak, Đ., Mikhailidis, D., Rizzo, M.,& Isenović, E.. (2012). Ghrelin, obesity and atherosclerosis. in Ghrelin: Production, Action Mechanisms and Physiological Effects
Nova Science Publishers Inc, New York., 111-126.
https://hdl.handle.net/21.15107/rcub_cherry_3919

Sudar E, Soskić S, Zarić BL, Rašić-Milutinović Z, Smiljanić K, Radak Đ, Mikhailidis D, Rizzo M, Isenović E. Ghrelin, obesity and atherosclerosis. in Ghrelin: Production, Action Mechanisms and Physiological Effects. 2012;:111-126.
https://hdl.handle.net/21.15107/rcub_cherry_3919 .

Sudar, Emina, Soskić, Sanja, Zarić, Božidarka L., Rašić-Milutinović, Zorica, Smiljanić, Katarina, Radak, Đorđe, Mikhailidis, Dimitri, Rizzo, Manfredi, Isenović, Esma, "Ghrelin, obesity and atherosclerosis" in Ghrelin: Production, Action Mechanisms and Physiological Effects (2012):111-126,
https://hdl.handle.net/21.15107/rcub_cherry_3919 .

TY  - CHAP
AU  - Sudar, Emina
AU  - Soskić, Sanja
AU  - Zarić, Božidarka L.
AU  - Rašić-Milutinović, Zorica
AU  - Smiljanić, Katarina
AU  - Radak, Đorđe
AU  - Mikhailidis, Dimitri
AU  - Rizzo, Manfredi
AU  - Isenović, Esma
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3920
AB  - Cardiovascular disease (CVD) is common cause of death in humans and its major underlying pathology is atherosclerosis. Atherosclerosis is a chronic inflammatory disease that predisposes to coronary artery disease (CAD), stroke and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality. This inflammatory process, triggered by the presence of lipids in the vascular wall, and encompasses a complex interaction among inflammatory cells, vascular elements, and lipoproteins through the expression of several adhesion molecules and cytokines. Obesity is a risk factor for CVD but this association is not fully understood. Altered levels of obesity related peptides such as ghrelin may play an important role in this pathophysiology. Recent evidence indicates that ghrelin features several cardiovascular activities, including increased myocardial contractility, vasodilatation and protection from myocardial infarction. Recent data demonstrate that ghrelin can influence important key events in atherogenesis and thus they may play a role in atherosclerosis. In this review we present the latest data from recent animal and clinical studies which focus on a novel approach to ghrelin as a potential therapeutic agent in the treatment of a complex disease like atherosclerosis. Thus, ghrelin may become a new therapeutic target for the treatment of CVD. Further studies are necessary to investigate the potential mechanisms involved in the effects of ghrelin on the cardiovascular system.
PB  - Nova Science Publishers Inc, New York
T2  - Ghrelin: Production, Action Mechanisms and Physiological Effects
T1  - Ghrelin, obesity and atherosclerosis
SP  - 111
EP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3920
ER  - 

@inbook{
author = "Sudar, Emina and Soskić, Sanja and Zarić, Božidarka L. and Rašić-Milutinović, Zorica and Smiljanić, Katarina and Radak, Đorđe and Mikhailidis, Dimitri and Rizzo, Manfredi and Isenović, Esma",
year = "2012",
abstract = "Cardiovascular disease (CVD) is common cause of death in humans and its major underlying pathology is atherosclerosis. Atherosclerosis is a chronic inflammatory disease that predisposes to coronary artery disease (CAD), stroke and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality. This inflammatory process, triggered by the presence of lipids in the vascular wall, and encompasses a complex interaction among inflammatory cells, vascular elements, and lipoproteins through the expression of several adhesion molecules and cytokines. Obesity is a risk factor for CVD but this association is not fully understood. Altered levels of obesity related peptides such as ghrelin may play an important role in this pathophysiology. Recent evidence indicates that ghrelin features several cardiovascular activities, including increased myocardial contractility, vasodilatation and protection from myocardial infarction. Recent data demonstrate that ghrelin can influence important key events in atherogenesis and thus they may play a role in atherosclerosis. In this review we present the latest data from recent animal and clinical studies which focus on a novel approach to ghrelin as a potential therapeutic agent in the treatment of a complex disease like atherosclerosis. Thus, ghrelin may become a new therapeutic target for the treatment of CVD. Further studies are necessary to investigate the potential mechanisms involved in the effects of ghrelin on the cardiovascular system.",
publisher = "Nova Science Publishers Inc, New York",
journal = "Ghrelin: Production, Action Mechanisms and Physiological Effects",
booktitle = "Ghrelin, obesity and atherosclerosis",
pages = "111-126",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3920"
}

Sudar, E., Soskić, S., Zarić, B. L., Rašić-Milutinović, Z., Smiljanić, K., Radak, Đ., Mikhailidis, D., Rizzo, M.,& Isenović, E.. (2012). Ghrelin, obesity and atherosclerosis. in Ghrelin: Production, Action Mechanisms and Physiological Effects
Nova Science Publishers Inc, New York., 111-126.
https://hdl.handle.net/21.15107/rcub_cherry_3920

Sudar E, Soskić S, Zarić BL, Rašić-Milutinović Z, Smiljanić K, Radak Đ, Mikhailidis D, Rizzo M, Isenović E. Ghrelin, obesity and atherosclerosis. in Ghrelin: Production, Action Mechanisms and Physiological Effects. 2012;:111-126.
https://hdl.handle.net/21.15107/rcub_cherry_3920 .

Sudar, Emina, Soskić, Sanja, Zarić, Božidarka L., Rašić-Milutinović, Zorica, Smiljanić, Katarina, Radak, Đorđe, Mikhailidis, Dimitri, Rizzo, Manfredi, Isenović, Esma, "Ghrelin, obesity and atherosclerosis" in Ghrelin: Production, Action Mechanisms and Physiological Effects (2012):111-126,
https://hdl.handle.net/21.15107/rcub_cherry_3920 .

TY  - JOUR
AU  - Jovanović, Dragana
AU  - Paunović, Katarina
AU  - Manojlović, Dragan D.
AU  - Jakovljević, Branko
AU  - Rašić-Milutinović, Zorica
AU  - Dojčinović, Biljana P.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1524
AB  - Background: Arsenic is constantly present in drinking water supply systems of Zrenjanin municipality across decades. It presents a great public health problem in Serbia, but its relationship with acute coronary syndrome (ACS) has not been studied previously. Objectives: The aims of this study were to assess the incidence of ACS in two areas from Zrenjanin municipality consuming different levels of arsenic in drinking water, and to explore the association between arsenic exposure and the probability of fatal outcome of ACS. Methods: The research was a registry-based ecological study of two populations consuming water with different arsenic levels, based on current guidelines (10 mu g/L). Median arsenic in the area above national standard was 80 mu g/L; median arsenic in the other area was 1 mu g/L. Newly diagnosed cases of ACS were obtained from the National Registry for Acute Coronary Syndrome from 2006 to 2010. Results: The two populations were comparable by age, gender, and prevalence of risk factors for ACS. Standardized incidence rates (SIR) of ACS were higher for people consuming arsenic above standard (average five-year SIR was 237.00 per 100.000: 95% CI=214.93-260.74), in comparison to people consuming arsenic within limits (average SIR=124.40 per 100.000; 95% CI=96.00-158.56). Exposure to arsenic above limits was insignificantly associated with fatal outcome of ACS for the whole population, men and women. Conclusions: Consumption of arsenic above national standards was associated with higher risk for the occurrence of acute coronary syndrome and with insignificantly higher probability of fatal outcome of ACS in Zrenjanin municipality. (C) 2012 Elsevier Inc. All rights reserved.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Environmental Research
T1  - Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia
VL  - 117
SP  - 75
EP  - 82
DO  - 10.1016/j.envres.2012.04.016
ER  - 

@article{
author = "Jovanović, Dragana and Paunović, Katarina and Manojlović, Dragan D. and Jakovljević, Branko and Rašić-Milutinović, Zorica and Dojčinović, Biljana P.",
year = "2012",
abstract = "Background: Arsenic is constantly present in drinking water supply systems of Zrenjanin municipality across decades. It presents a great public health problem in Serbia, but its relationship with acute coronary syndrome (ACS) has not been studied previously. Objectives: The aims of this study were to assess the incidence of ACS in two areas from Zrenjanin municipality consuming different levels of arsenic in drinking water, and to explore the association between arsenic exposure and the probability of fatal outcome of ACS. Methods: The research was a registry-based ecological study of two populations consuming water with different arsenic levels, based on current guidelines (10 mu g/L). Median arsenic in the area above national standard was 80 mu g/L; median arsenic in the other area was 1 mu g/L. Newly diagnosed cases of ACS were obtained from the National Registry for Acute Coronary Syndrome from 2006 to 2010. Results: The two populations were comparable by age, gender, and prevalence of risk factors for ACS. Standardized incidence rates (SIR) of ACS were higher for people consuming arsenic above standard (average five-year SIR was 237.00 per 100.000: 95% CI=214.93-260.74), in comparison to people consuming arsenic within limits (average SIR=124.40 per 100.000; 95% CI=96.00-158.56). Exposure to arsenic above limits was insignificantly associated with fatal outcome of ACS for the whole population, men and women. Conclusions: Consumption of arsenic above national standards was associated with higher risk for the occurrence of acute coronary syndrome and with insignificantly higher probability of fatal outcome of ACS in Zrenjanin municipality. (C) 2012 Elsevier Inc. All rights reserved.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Environmental Research",
title = "Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia",
volume = "117",
pages = "75-82",
doi = "10.1016/j.envres.2012.04.016"
}

Jovanović, D., Paunović, K., Manojlović, D. D., Jakovljević, B., Rašić-Milutinović, Z.,& Dojčinović, B. P.. (2012). Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia. in Environmental Research
Academic Press Inc Elsevier Science, San Diego., 117, 75-82.
https://doi.org/10.1016/j.envres.2012.04.016

Jovanović D, Paunović K, Manojlović DD, Jakovljević B, Rašić-Milutinović Z, Dojčinović BP. Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia. in Environmental Research. 2012;117:75-82.
doi:10.1016/j.envres.2012.04.016 .

Jovanović, Dragana, Paunović, Katarina, Manojlović, Dragan D., Jakovljević, Branko, Rašić-Milutinović, Zorica, Dojčinović, Biljana P., "Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia" in Environmental Research, 117 (2012):75-82,
https://doi.org/10.1016/j.envres.2012.04.016 . .