TY  - JOUR
AU  - Opsenica, Igor
AU  - Opsenica, Dejan M.
AU  - Jadranin, Milka
AU  - Smith, Kirsten S.
AU  - Milhous, Wilbur K.
AU  - Stratakis, Manolis
AU  - Šolaja, Bogdan A.
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/901
AB  - Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized.
AB  - U ovom radu prikazana je sinteza nekoliko dicikiloheksilidenskih tetraoksana u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja 2-5 dobijena kao (cis,trans)-smese pokazala su izraženu antimalarijsku aktivnost prema D6, W2 i TM91C235 (Thailand) sojevima P. falciparum. Ona imaju bolju ili sličnu aktivnost od odgovarajućih desmetil cikloheksilidenskih derivata. Sintetisana su i dva endoperoksida himerne strukture znatno izraženije aktivnosti od prirodnog proizvoda askaridola. .
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - On peroxide antimalarials
T1  - O peroksidnim antimalaricima
VL  - 72
IS  - 12
SP  - 1181
EP  - 1190
DO  - 10.2298/JSC0712181O
ER  - 

@article{
author = "Opsenica, Igor and Opsenica, Dejan M. and Jadranin, Milka and Smith, Kirsten S. and Milhous, Wilbur K. and Stratakis, Manolis and Šolaja, Bogdan A.",
year = "2007",
abstract = "Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized., U ovom radu prikazana je sinteza nekoliko dicikiloheksilidenskih tetraoksana u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja 2-5 dobijena kao (cis,trans)-smese pokazala su izraženu antimalarijsku aktivnost prema D6, W2 i TM91C235 (Thailand) sojevima P. falciparum. Ona imaju bolju ili sličnu aktivnost od odgovarajućih desmetil cikloheksilidenskih derivata. Sintetisana su i dva endoperoksida himerne strukture znatno izraženije aktivnosti od prirodnog proizvoda askaridola. .",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "On peroxide antimalarials, O peroksidnim antimalaricima",
volume = "72",
number = "12",
pages = "1181-1190",
doi = "10.2298/JSC0712181O"
}

Opsenica, I., Opsenica, D. M., Jadranin, M., Smith, K. S., Milhous, W. K., Stratakis, M.,& Šolaja, B. A.. (2007). On peroxide antimalarials. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 72(12), 1181-1190.
https://doi.org/10.2298/JSC0712181O

Opsenica I, Opsenica DM, Jadranin M, Smith KS, Milhous WK, Stratakis M, Šolaja BA. On peroxide antimalarials. in Journal of the Serbian Chemical Society. 2007;72(12):1181-1190.
doi:10.2298/JSC0712181O .

Opsenica, Igor, Opsenica, Dejan M., Jadranin, Milka, Smith, Kirsten S., Milhous, Wilbur K., Stratakis, Manolis, Šolaja, Bogdan A., "On peroxide antimalarials" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1181-1190,
https://doi.org/10.2298/JSC0712181O . .

TY  - JOUR
AU  - Hatzakis, Emmanuel
AU  - Opsenica, Igor
AU  - Šolaja, Bogdan A.
AU  - Stratakis, Manolis
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/861
AB  - Novel polar derivatives of the antimalarial endoperoxide ascaridole were synthesized based on the zeolite NaY-promoted isomerization of perillyl and nopol derivatives to conjugated cyclohexadienes, followed by reaction with singlet oxygen. Several unsaturated endoperoxides were in situ reduced with diimide to form dihydroascaridole derivatives, as well.
PB  - Arkat Usa Inc, Gainesville
T2  - Arkivoc
T1  - Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole
SP  - 124
EP  - 135
UR  - https://hdl.handle.net/21.15107/rcub_cherry_861
ER  - 

@article{
author = "Hatzakis, Emmanuel and Opsenica, Igor and Šolaja, Bogdan A. and Stratakis, Manolis",
year = "2007",
abstract = "Novel polar derivatives of the antimalarial endoperoxide ascaridole were synthesized based on the zeolite NaY-promoted isomerization of perillyl and nopol derivatives to conjugated cyclohexadienes, followed by reaction with singlet oxygen. Several unsaturated endoperoxides were in situ reduced with diimide to form dihydroascaridole derivatives, as well.",
publisher = "Arkat Usa Inc, Gainesville",
journal = "Arkivoc",
title = "Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole",
pages = "124-135",
url = "https://hdl.handle.net/21.15107/rcub_cherry_861"
}

Hatzakis, E., Opsenica, I., Šolaja, B. A.,& Stratakis, M.. (2007). Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole. in Arkivoc
Arkat Usa Inc, Gainesville., 124-135.
https://hdl.handle.net/21.15107/rcub_cherry_861

Hatzakis E, Opsenica I, Šolaja BA, Stratakis M. Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole. in Arkivoc. 2007;:124-135.
https://hdl.handle.net/21.15107/rcub_cherry_861 .

Hatzakis, Emmanuel, Opsenica, Igor, Šolaja, Bogdan A., Stratakis, Manolis, "Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole" in Arkivoc (2007):124-135,
https://hdl.handle.net/21.15107/rcub_cherry_861 .