TY  - JOUR
AU  - Jankovic, S.M.
AU  - Beleslin, D.
AU  - Ivanović, Milovan
AU  - Kouvelas, D.
AU  - Argyriou, A.
AU  - Đorđević, S.
AU  - Mirtsou-Fidani, V.
PY  - 1997
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/45
AB  - Opiates inhibit electrically-stimulated contractions of isolated rat ileum acting on δ-receptors. We have examined effects of fentanyl and its three analogues on contractions of isolated rat ileum stimulated by electric field (20 V, 22 ms, 1 Hz). Fentanyl (from 10-9 M to 10-7 M) and trans-3-(carbomethoxy) fentanyl (from 10-7 M to 10-5 M) produced concentration-dependent decrease in amplitude of stimulated contractions, only fentanyl was about 40 times more potent. Cis-3-(methyl) fentanyl and Cis-3-(carbomethoxy) fentanyl did not affect stimulated contractions. Our study suggested that introduction of methyl and carbomethoxy moieties on position 3 of piperidine ring produced loss of fentanyl activity on δ-opioid receptors, cis-orientation being specially uafavourable.
T2  - Archives of Gastroenterohepatology
T1  - Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum
VL  - 16
IS  - 2
SP  - 29
EP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_cherry_45
ER  - 

@article{
author = "Jankovic, S.M. and Beleslin, D. and Ivanović, Milovan and Kouvelas, D. and Argyriou, A. and Đorđević, S. and Mirtsou-Fidani, V.",
year = "1997",
abstract = "Opiates inhibit electrically-stimulated contractions of isolated rat ileum acting on δ-receptors. We have examined effects of fentanyl and its three analogues on contractions of isolated rat ileum stimulated by electric field (20 V, 22 ms, 1 Hz). Fentanyl (from 10-9 M to 10-7 M) and trans-3-(carbomethoxy) fentanyl (from 10-7 M to 10-5 M) produced concentration-dependent decrease in amplitude of stimulated contractions, only fentanyl was about 40 times more potent. Cis-3-(methyl) fentanyl and Cis-3-(carbomethoxy) fentanyl did not affect stimulated contractions. Our study suggested that introduction of methyl and carbomethoxy moieties on position 3 of piperidine ring produced loss of fentanyl activity on δ-opioid receptors, cis-orientation being specially uafavourable.",
journal = "Archives of Gastroenterohepatology",
title = "Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum",
volume = "16",
number = "2",
pages = "29-32",
url = "https://hdl.handle.net/21.15107/rcub_cherry_45"
}

Jankovic, S.M., Beleslin, D., Ivanović, M., Kouvelas, D., Argyriou, A., Đorđević, S.,& Mirtsou-Fidani, V.. (1997). Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum. in Archives of Gastroenterohepatology, 16(2), 29-32.
https://hdl.handle.net/21.15107/rcub_cherry_45

Jankovic S, Beleslin D, Ivanović M, Kouvelas D, Argyriou A, Đorđević S, Mirtsou-Fidani V. Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum. in Archives of Gastroenterohepatology. 1997;16(2):29-32.
https://hdl.handle.net/21.15107/rcub_cherry_45 .

Jankovic, S.M., Beleslin, D., Ivanović, Milovan, Kouvelas, D., Argyriou, A., Đorđević, S., Mirtsou-Fidani, V., "Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum" in Archives of Gastroenterohepatology, 16, no. 2 (1997):29-32,
https://hdl.handle.net/21.15107/rcub_cherry_45 .