TY  - JOUR
AU  - Stevanović, Nikola R.
AU  - Mijatović, Aleksandar
AU  - Lolić, Aleksandar
AU  - Zlatović, Mario
AU  - Baošić, Rada
PY  - 2022
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4707
AB  - The influences of the application of mono- and two-component organic modifiers on lipophilicity determination of 12 tetradentate Schiff bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifiers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible for the behaviour of substances in both the biological and chromatographic system. The applied organic modifier shows the ability to modify the surface of the applied sorbent, which affects the manifestation of lipophilicity of the observed compounds. Mono-component organic modifiers from different groups of the Snyder triangle were used, as well as their two-component mixtures. In addition, we compared experimentally determined calculated parameters of lipophilicity.
PB  - Springer
T2  - Chemical Papers
T1  - Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases
VL  - 76
SP  - 585
EP  - 593
DO  - 10.1007/s11696-021-01884-5
ER  - 

@article{
author = "Stevanović, Nikola R. and Mijatović, Aleksandar and Lolić, Aleksandar and Zlatović, Mario and Baošić, Rada",
year = "2022",
abstract = "The influences of the application of mono- and two-component organic modifiers on lipophilicity determination of 12 tetradentate Schiff bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifiers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible for the behaviour of substances in both the biological and chromatographic system. The applied organic modifier shows the ability to modify the surface of the applied sorbent, which affects the manifestation of lipophilicity of the observed compounds. Mono-component organic modifiers from different groups of the Snyder triangle were used, as well as their two-component mixtures. In addition, we compared experimentally determined calculated parameters of lipophilicity.",
publisher = "Springer",
journal = "Chemical Papers",
title = "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases",
volume = "76",
pages = "585-593",
doi = "10.1007/s11696-021-01884-5"
}

Stevanović, N. R., Mijatović, A., Lolić, A., Zlatović, M.,& Baošić, R.. (2022). Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases. in Chemical Papers
Springer., 76, 585-593.
https://doi.org/10.1007/s11696-021-01884-5

Stevanović NR, Mijatović A, Lolić A, Zlatović M, Baošić R. Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases. in Chemical Papers. 2022;76:585-593.
doi:10.1007/s11696-021-01884-5 .

Stevanović, Nikola R., Mijatović, Aleksandar, Lolić, Aleksandar, Zlatović, Mario, Baošić, Rada, "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases" in Chemical Papers, 76 (2022):585-593,
https://doi.org/10.1007/s11696-021-01884-5 . .

TY  - JOUR
AU  - Peruško, Marija
AU  - Ghnimi, Sami
AU  - Simović, Ana
AU  - Stevanović, Nikola R.
AU  - Radomirović, Mirjana Ž.
AU  - Gharsallaoui, Adem
AU  - Smiljanić, Katarina
AU  - Van Haute, Sam
AU  - Stanić-Vučinić, Dragana
AU  - Ćirković-Veličković, Tanja
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4333
AB  - Demand for camel milk (CM) is increasing worldwide, due to its high nutritious value and health benefits. In this study, whole CM powders were produced by spray drying (SD) at six inlet temperatures (190 °C–250 °C) and by freeze drying (FD). Physicochemical and functional properties of CM powder proteins were investigated. SD at higher inlet temperatures (230 °C–250 °C) resulted in higher extent of Maillard reaction (MR), in comparison to lower temperatures (190 °C–200 °C) and FD treatment. Both treatments had negative effect on casein solubility, while whey proteins remained soluble and slightly increased its solubility with the extent of MR. The CM powders obtained at higher inlet temperatures demonstrated improved antioxidant activity. Secondary structure of whey proteins did not differ among the samples, while surface hydrophobicity of whey proteins was higher in all SD than in FD samples, suggesting only limited denaturation of camel whey proteins at higher inlet temperatures of drying. Thus, the effects of SD under the conditions applied in our study did not decrease camel whey protein solubility, while drying procedure itself regardless of temperature decreased solubility of camel milk caseins. MR generated during CM processing could be an important means of compensating for the lack of antioxidant protection normally associated with β-lactoglobulin but happens to be absent from this milk.
PB  - Elsevier
T2  - LWT
T1  - Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying
VL  - 143
SP  - 111091
DO  - 10.1016/j.lwt.2021.111091
ER  - 

@article{
author = "Peruško, Marija and Ghnimi, Sami and Simović, Ana and Stevanović, Nikola R. and Radomirović, Mirjana Ž. and Gharsallaoui, Adem and Smiljanić, Katarina and Van Haute, Sam and Stanić-Vučinić, Dragana and Ćirković-Veličković, Tanja",
year = "2021",
abstract = "Demand for camel milk (CM) is increasing worldwide, due to its high nutritious value and health benefits. In this study, whole CM powders were produced by spray drying (SD) at six inlet temperatures (190 °C–250 °C) and by freeze drying (FD). Physicochemical and functional properties of CM powder proteins were investigated. SD at higher inlet temperatures (230 °C–250 °C) resulted in higher extent of Maillard reaction (MR), in comparison to lower temperatures (190 °C–200 °C) and FD treatment. Both treatments had negative effect on casein solubility, while whey proteins remained soluble and slightly increased its solubility with the extent of MR. The CM powders obtained at higher inlet temperatures demonstrated improved antioxidant activity. Secondary structure of whey proteins did not differ among the samples, while surface hydrophobicity of whey proteins was higher in all SD than in FD samples, suggesting only limited denaturation of camel whey proteins at higher inlet temperatures of drying. Thus, the effects of SD under the conditions applied in our study did not decrease camel whey protein solubility, while drying procedure itself regardless of temperature decreased solubility of camel milk caseins. MR generated during CM processing could be an important means of compensating for the lack of antioxidant protection normally associated with β-lactoglobulin but happens to be absent from this milk.",
publisher = "Elsevier",
journal = "LWT",
title = "Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying",
volume = "143",
pages = "111091",
doi = "10.1016/j.lwt.2021.111091"
}

Peruško, M., Ghnimi, S., Simović, A., Stevanović, N. R., Radomirović, M. Ž., Gharsallaoui, A., Smiljanić, K., Van Haute, S., Stanić-Vučinić, D.,& Ćirković-Veličković, T.. (2021). Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying. in LWT
Elsevier., 143, 111091.
https://doi.org/10.1016/j.lwt.2021.111091

Peruško M, Ghnimi S, Simović A, Stevanović NR, Radomirović MŽ, Gharsallaoui A, Smiljanić K, Van Haute S, Stanić-Vučinić D, Ćirković-Veličković T. Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying. in LWT. 2021;143:111091.
doi:10.1016/j.lwt.2021.111091 .

Peruško, Marija, Ghnimi, Sami, Simović, Ana, Stevanović, Nikola R., Radomirović, Mirjana Ž., Gharsallaoui, Adem, Smiljanić, Katarina, Van Haute, Sam, Stanić-Vučinić, Dragana, Ćirković-Veličković, Tanja, "Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying" in LWT, 143 (2021):111091,
https://doi.org/10.1016/j.lwt.2021.111091 . .

TY  - DATA
AU  - Peruško, Marija
AU  - Ghnimi, Sami
AU  - Simović, Ana
AU  - Stevanović, Nikola R.
AU  - Radomirović, Mirjana Ž.
AU  - Gharsallaoui, Adem
AU  - Smiljanić, Katarina
AU  - Van Haute, Sam
AU  - Stanić-Vučinić, Dragana
AU  - Ćirković-Veličković, Tanja
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4334
PB  - Elsevier
T2  - LWT
T1  - Supplementary data for the article: Perusko, M.; Ghnimi, S.; Simovic, A.; Stevanovic, N.; Radomirovic, M.; Gharsallaoui, A.; Smiljanic, K.; Van Haute, S.; Stanic-Vucinic, D.; Cirkovic Velickovic, T. Maillard Reaction Products Formation and Antioxidative Power of Spray Dried Camel Milk Powders Increases with the Inlet Temperature of Drying. LWT 2021, 143, 111091. https://doi.org/10.1016/j.lwt.2021.111091.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4334
ER  - 

@misc{
author = "Peruško, Marija and Ghnimi, Sami and Simović, Ana and Stevanović, Nikola R. and Radomirović, Mirjana Ž. and Gharsallaoui, Adem and Smiljanić, Katarina and Van Haute, Sam and Stanić-Vučinić, Dragana and Ćirković-Veličković, Tanja",
year = "2021",
publisher = "Elsevier",
journal = "LWT",
title = "Supplementary data for the article: Perusko, M.; Ghnimi, S.; Simovic, A.; Stevanovic, N.; Radomirovic, M.; Gharsallaoui, A.; Smiljanic, K.; Van Haute, S.; Stanic-Vucinic, D.; Cirkovic Velickovic, T. Maillard Reaction Products Formation and Antioxidative Power of Spray Dried Camel Milk Powders Increases with the Inlet Temperature of Drying. LWT 2021, 143, 111091. https://doi.org/10.1016/j.lwt.2021.111091.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4334"
}

Peruško, M., Ghnimi, S., Simović, A., Stevanović, N. R., Radomirović, M. Ž., Gharsallaoui, A., Smiljanić, K., Van Haute, S., Stanić-Vučinić, D.,& Ćirković-Veličković, T.. (2021). Supplementary data for the article: Perusko, M.; Ghnimi, S.; Simovic, A.; Stevanovic, N.; Radomirovic, M.; Gharsallaoui, A.; Smiljanic, K.; Van Haute, S.; Stanic-Vucinic, D.; Cirkovic Velickovic, T. Maillard Reaction Products Formation and Antioxidative Power of Spray Dried Camel Milk Powders Increases with the Inlet Temperature of Drying. LWT 2021, 143, 111091. https://doi.org/10.1016/j.lwt.2021.111091.. in LWT
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4334

Peruško M, Ghnimi S, Simović A, Stevanović NR, Radomirović MŽ, Gharsallaoui A, Smiljanić K, Van Haute S, Stanić-Vučinić D, Ćirković-Veličković T. Supplementary data for the article: Perusko, M.; Ghnimi, S.; Simovic, A.; Stevanovic, N.; Radomirovic, M.; Gharsallaoui, A.; Smiljanic, K.; Van Haute, S.; Stanic-Vucinic, D.; Cirkovic Velickovic, T. Maillard Reaction Products Formation and Antioxidative Power of Spray Dried Camel Milk Powders Increases with the Inlet Temperature of Drying. LWT 2021, 143, 111091. https://doi.org/10.1016/j.lwt.2021.111091.. in LWT. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4334 .

Peruško, Marija, Ghnimi, Sami, Simović, Ana, Stevanović, Nikola R., Radomirović, Mirjana Ž., Gharsallaoui, Adem, Smiljanić, Katarina, Van Haute, Sam, Stanić-Vučinić, Dragana, Ćirković-Veličković, Tanja, "Supplementary data for the article: Perusko, M.; Ghnimi, S.; Simovic, A.; Stevanovic, N.; Radomirovic, M.; Gharsallaoui, A.; Smiljanic, K.; Van Haute, S.; Stanic-Vucinic, D.; Cirkovic Velickovic, T. Maillard Reaction Products Formation and Antioxidative Power of Spray Dried Camel Milk Powders Increases with the Inlet Temperature of Drying. LWT 2021, 143, 111091. https://doi.org/10.1016/j.lwt.2021.111091." in LWT (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4334 .

TY  - DATA
AU  - Khulal, Urmila
AU  - Ghnimi, Sami
AU  - Stevanović, Nikola R.
AU  - Rajković, Andreja
AU  - Ćirković-Veličković, Tanja
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4747
PB  - Elsevier
T2  - LWT
T1  - Supplementary data for the article: Khulal, U.; Ghnimi, S.; Stevanovic, N.; Rajkovic, A.; Cirkovic Velickovic, T. Aggregability and Digestibility Study of Fruit Juice Fortified Camel Milk Powder Proteins. LWT 2021, 152, 112250. https://doi.org/10.1016/j.lwt.2021.112250.
VL  - 152
SP  - 112250
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4747
ER  - 

@misc{
author = "Khulal, Urmila and Ghnimi, Sami and Stevanović, Nikola R. and Rajković, Andreja and Ćirković-Veličković, Tanja",
year = "2021",
publisher = "Elsevier",
journal = "LWT",
title = "Supplementary data for the article: Khulal, U.; Ghnimi, S.; Stevanovic, N.; Rajkovic, A.; Cirkovic Velickovic, T. Aggregability and Digestibility Study of Fruit Juice Fortified Camel Milk Powder Proteins. LWT 2021, 152, 112250. https://doi.org/10.1016/j.lwt.2021.112250.",
volume = "152",
pages = "112250",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4747"
}

Khulal, U., Ghnimi, S., Stevanović, N. R., Rajković, A.,& Ćirković-Veličković, T.. (2021). Supplementary data for the article: Khulal, U.; Ghnimi, S.; Stevanovic, N.; Rajkovic, A.; Cirkovic Velickovic, T. Aggregability and Digestibility Study of Fruit Juice Fortified Camel Milk Powder Proteins. LWT 2021, 152, 112250. https://doi.org/10.1016/j.lwt.2021.112250.. in LWT
Elsevier., 152, 112250.
https://hdl.handle.net/21.15107/rcub_cherry_4747

Khulal U, Ghnimi S, Stevanović NR, Rajković A, Ćirković-Veličković T. Supplementary data for the article: Khulal, U.; Ghnimi, S.; Stevanovic, N.; Rajkovic, A.; Cirkovic Velickovic, T. Aggregability and Digestibility Study of Fruit Juice Fortified Camel Milk Powder Proteins. LWT 2021, 152, 112250. https://doi.org/10.1016/j.lwt.2021.112250.. in LWT. 2021;152:112250.
https://hdl.handle.net/21.15107/rcub_cherry_4747 .

Khulal, Urmila, Ghnimi, Sami, Stevanović, Nikola R., Rajković, Andreja, Ćirković-Veličković, Tanja, "Supplementary data for the article: Khulal, U.; Ghnimi, S.; Stevanovic, N.; Rajkovic, A.; Cirkovic Velickovic, T. Aggregability and Digestibility Study of Fruit Juice Fortified Camel Milk Powder Proteins. LWT 2021, 152, 112250. https://doi.org/10.1016/j.lwt.2021.112250." in LWT, 152 (2021):112250,
https://hdl.handle.net/21.15107/rcub_cherry_4747 .

TY  - JOUR
AU  - Stevanović, Nikola R.
AU  - Apostolović, Danijela
AU  - Milčić, Miloš K.
AU  - Lolić, Aleksandar
AU  - Hage, Marianne van
AU  - Ćirković-Veličković, Tanja
AU  - Baošić, Rada
PY  - 2021
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/nj/d1nj00040c
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4399
AB  - Different Schiff base complexes have biological activities that make them suitable for drug design. The biological properties of tetradentate Schiff base copper(II) complexed with N,N′-bis(acetylacetone)propylenediimine have been studied. The cytotoxic activity towards Caco-2 cells were determined by MTT, Anexin V and PI apoptosis assays. N,N′-bis(acetylacetone)propylenediimine-copper(II) showed the anti-cancer and anti-proliferative properties by inducing apoptosis in Caco-2 cells. A comparison of the cytotoxic activity of this compound with cisplatin shows that it is more effective on the colorectal cancer cell line Caco-2. The binding capacity and interaction of N,N′-bis(acetylacetone)propylenediimine-copper(II) with HSA were systemically investigated by in vitro fluorescence spectroscopy, CD spectroscopy, and in silico molecular docking study. Furthermore, in vitro and in silico interaction studies indicated that the complex binds to HSA through a static quenching mechanism without changes in protein conformation. The calculated number of binding sites was in line with molecular docking studies. The obtained Ka value suggests that the compound can be released from the protein in target cells. The tetradentate Schiff base copper(II) complex exhibited in vitro biological activities against cancer epithelial cells, which depend on the molecular structure of the complex, causing apoptosis, and the complex can bind to the protein drug carrier in circulation to the target tissue.
T2  - New Journal of Chemistry
T1  - Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2
VL  - 45
IS  - 14
SP  - 6231
EP  - 6237
DO  - 10.1039/D1NJ00040C
ER  - 

@article{
author = "Stevanović, Nikola R. and Apostolović, Danijela and Milčić, Miloš K. and Lolić, Aleksandar and Hage, Marianne van and Ćirković-Veličković, Tanja and Baošić, Rada",
year = "2021",
abstract = "Different Schiff base complexes have biological activities that make them suitable for drug design. The biological properties of tetradentate Schiff base copper(II) complexed with N,N′-bis(acetylacetone)propylenediimine have been studied. The cytotoxic activity towards Caco-2 cells were determined by MTT, Anexin V and PI apoptosis assays. N,N′-bis(acetylacetone)propylenediimine-copper(II) showed the anti-cancer and anti-proliferative properties by inducing apoptosis in Caco-2 cells. A comparison of the cytotoxic activity of this compound with cisplatin shows that it is more effective on the colorectal cancer cell line Caco-2. The binding capacity and interaction of N,N′-bis(acetylacetone)propylenediimine-copper(II) with HSA were systemically investigated by in vitro fluorescence spectroscopy, CD spectroscopy, and in silico molecular docking study. Furthermore, in vitro and in silico interaction studies indicated that the complex binds to HSA through a static quenching mechanism without changes in protein conformation. The calculated number of binding sites was in line with molecular docking studies. The obtained Ka value suggests that the compound can be released from the protein in target cells. The tetradentate Schiff base copper(II) complex exhibited in vitro biological activities against cancer epithelial cells, which depend on the molecular structure of the complex, causing apoptosis, and the complex can bind to the protein drug carrier in circulation to the target tissue.",
journal = "New Journal of Chemistry",
title = "Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2",
volume = "45",
number = "14",
pages = "6231-6237",
doi = "10.1039/D1NJ00040C"
}

Stevanović, N. R., Apostolović, D., Milčić, M. K., Lolić, A., Hage, M. v., Ćirković-Veličković, T.,& Baošić, R.. (2021). Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2. in New Journal of Chemistry, 45(14), 6231-6237.
https://doi.org/10.1039/D1NJ00040C

Stevanović NR, Apostolović D, Milčić MK, Lolić A, Hage MV, Ćirković-Veličković T, Baošić R. Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2. in New Journal of Chemistry. 2021;45(14):6231-6237.
doi:10.1039/D1NJ00040C .

Stevanović, Nikola R., Apostolović, Danijela, Milčić, Miloš K., Lolić, Aleksandar, Hage, Marianne van, Ćirković-Veličković, Tanja, Baošić, Rada, "Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2" in New Journal of Chemistry, 45, no. 14 (2021):6231-6237,
https://doi.org/10.1039/D1NJ00040C . .

TY  - DATA
AU  - Stevanović, Nikola R.
AU  - Apostolović, Danijela
AU  - Milčić, Miloš K.
AU  - Lolić, Aleksandar
AU  - Hage, Marianne van
AU  - Ćirković-Veličković, Tanja
AU  - Baošić, Rada
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4400
T2  - New Journal of Chemistry
T1  - Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4400
ER  - 

@misc{
author = "Stevanović, Nikola R. and Apostolović, Danijela and Milčić, Miloš K. and Lolić, Aleksandar and Hage, Marianne van and Ćirković-Veličković, Tanja and Baošić, Rada",
year = "2021",
journal = "New Journal of Chemistry",
title = "Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4400"
}

Stevanović, N. R., Apostolović, D., Milčić, M. K., Lolić, A., Hage, M. v., Ćirković-Veličković, T.,& Baošić, R.. (2021). Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.. in New Journal of Chemistry.
https://hdl.handle.net/21.15107/rcub_cherry_4400

Stevanović NR, Apostolović D, Milčić MK, Lolić A, Hage MV, Ćirković-Veličković T, Baošić R. Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.. in New Journal of Chemistry. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4400 .

Stevanović, Nikola R., Apostolović, Danijela, Milčić, Miloš K., Lolić, Aleksandar, Hage, Marianne van, Ćirković-Veličković, Tanja, Baošić, Rada, "Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C." in New Journal of Chemistry (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4400 .

TY  - JOUR
AU  - Stevanović, Nikola R.
AU  - Apostolović, Danijela
AU  - Milčić, Miloš K.
AU  - Lolić, Aleksandar
AU  - Hage, Marianne van
AU  - Ćirković-Veličković, Tanja
AU  - Baošić, Rada
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4856
AB  - Different Schiff base complexes have biological activities that make them suitable for drug design. The biological properties of tetradentate Schiff base copper(II) complexed with N,N′-bis(acetylacetone)propylenediimine have been studied. The cytotoxic activity towards Caco-2 cells were determined by MTT, Anexin V and PI apoptosis assays. N,N′-bis(acetylacetone)propylenediimine-copper(II) showed the anti-cancer and anti-proliferative properties by inducing apoptosis in Caco-2 cells. A comparison of the cytotoxic activity of this compound with cisplatin shows that it is more effective on the colorectal cancer cell line Caco-2. The binding capacity and interaction of N,N′-bis(acetylacetone)propylenediimine-copper(II) with HSA were systemically investigated by in vitro fluorescence spectroscopy, CD spectroscopy, and in silico molecular docking study. Furthermore, in vitro and in silico interaction studies indicated that the complex binds to HSA through a static quenching mechanism without changes in protein conformation. The calculated number of binding sites was in line with molecular docking studies. The obtained Ka value suggests that the compound can be released from the protein in target cells. The tetradentate Schiff base copper(II) complex exhibited in vitro biological activities against cancer epithelial cells, which depend on the molecular structure of the complex, causing apoptosis, and the complex can bind to the protein drug carrier in circulation to the target tissue.
T2  - New Journal of Chemistry
T1  - Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2
VL  - 45
IS  - 14
SP  - 6231
EP  - 6237
DO  - 10.1039/D1NJ00040C
ER  - 

@article{
author = "Stevanović, Nikola R. and Apostolović, Danijela and Milčić, Miloš K. and Lolić, Aleksandar and Hage, Marianne van and Ćirković-Veličković, Tanja and Baošić, Rada",
year = "2021",
abstract = "Different Schiff base complexes have biological activities that make them suitable for drug design. The biological properties of tetradentate Schiff base copper(II) complexed with N,N′-bis(acetylacetone)propylenediimine have been studied. The cytotoxic activity towards Caco-2 cells were determined by MTT, Anexin V and PI apoptosis assays. N,N′-bis(acetylacetone)propylenediimine-copper(II) showed the anti-cancer and anti-proliferative properties by inducing apoptosis in Caco-2 cells. A comparison of the cytotoxic activity of this compound with cisplatin shows that it is more effective on the colorectal cancer cell line Caco-2. The binding capacity and interaction of N,N′-bis(acetylacetone)propylenediimine-copper(II) with HSA were systemically investigated by in vitro fluorescence spectroscopy, CD spectroscopy, and in silico molecular docking study. Furthermore, in vitro and in silico interaction studies indicated that the complex binds to HSA through a static quenching mechanism without changes in protein conformation. The calculated number of binding sites was in line with molecular docking studies. The obtained Ka value suggests that the compound can be released from the protein in target cells. The tetradentate Schiff base copper(II) complex exhibited in vitro biological activities against cancer epithelial cells, which depend on the molecular structure of the complex, causing apoptosis, and the complex can bind to the protein drug carrier in circulation to the target tissue.",
journal = "New Journal of Chemistry",
title = "Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2",
volume = "45",
number = "14",
pages = "6231-6237",
doi = "10.1039/D1NJ00040C"
}

Stevanović, N. R., Apostolović, D., Milčić, M. K., Lolić, A., Hage, M. v., Ćirković-Veličković, T.,& Baošić, R.. (2021). Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2. in New Journal of Chemistry, 45(14), 6231-6237.
https://doi.org/10.1039/D1NJ00040C

Stevanović NR, Apostolović D, Milčić MK, Lolić A, Hage MV, Ćirković-Veličković T, Baošić R. Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2. in New Journal of Chemistry. 2021;45(14):6231-6237.
doi:10.1039/D1NJ00040C .

Stevanović, Nikola R., Apostolović, Danijela, Milčić, Miloš K., Lolić, Aleksandar, Hage, Marianne van, Ćirković-Veličković, Tanja, Baošić, Rada, "Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2" in New Journal of Chemistry, 45, no. 14 (2021):6231-6237,
https://doi.org/10.1039/D1NJ00040C . .

TY  - JOUR
AU  - Peruško, Marija
AU  - Ghnimi, Sami
AU  - Simović, Ana
AU  - Stevanović, Nikola R.
AU  - Radomirović, Mirjana Ž.
AU  - Gharsallaoui, Adem
AU  - Smiljanić, Katarina
AU  - Van Haute, Sam
AU  - Stanić-Vučinić, Dragana
AU  - Ćirković-Veličković, Tanja
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4332
AB  - Demand for camel milk (CM) is increasing worldwide, due to its high nutritious value and health benefits. In this study, whole CM powders were produced by spray drying (SD) at six inlet temperatures (190 °C–250 °C) and by freeze drying (FD). Physicochemical and functional properties of CM powder proteins were investigated. SD at higher inlet temperatures (230 °C–250 °C) resulted in higher extent of Maillard reaction (MR), in comparison to lower temperatures (190 °C–200 °C) and FD treatment. Both treatments had negative effect on casein solubility, while whey proteins remained soluble and slightly increased its solubility with the extent of MR. The CM powders obtained at higher inlet temperatures demonstrated improved antioxidant activity. Secondary structure of whey proteins did not differ among the samples, while surface hydrophobicity of whey proteins was higher in all SD than in FD samples, suggesting only limited denaturation of camel whey proteins at higher inlet temperatures of drying. Thus, the effects of SD under the conditions applied in our study did not decrease camel whey protein solubility, while drying procedure itself regardless of temperature decreased solubility of camel milk caseins. MR generated during CM processing could be an important means of compensating for the lack of antioxidant protection normally associated with β-lactoglobulin but happens to be absent from this milk.
PB  - Elsevier
T2  - LWT
T1  - Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying
VL  - 143
SP  - 111091
DO  - 10.1016/j.lwt.2021.111091
ER  - 

@article{
author = "Peruško, Marija and Ghnimi, Sami and Simović, Ana and Stevanović, Nikola R. and Radomirović, Mirjana Ž. and Gharsallaoui, Adem and Smiljanić, Katarina and Van Haute, Sam and Stanić-Vučinić, Dragana and Ćirković-Veličković, Tanja",
year = "2021",
abstract = "Demand for camel milk (CM) is increasing worldwide, due to its high nutritious value and health benefits. In this study, whole CM powders were produced by spray drying (SD) at six inlet temperatures (190 °C–250 °C) and by freeze drying (FD). Physicochemical and functional properties of CM powder proteins were investigated. SD at higher inlet temperatures (230 °C–250 °C) resulted in higher extent of Maillard reaction (MR), in comparison to lower temperatures (190 °C–200 °C) and FD treatment. Both treatments had negative effect on casein solubility, while whey proteins remained soluble and slightly increased its solubility with the extent of MR. The CM powders obtained at higher inlet temperatures demonstrated improved antioxidant activity. Secondary structure of whey proteins did not differ among the samples, while surface hydrophobicity of whey proteins was higher in all SD than in FD samples, suggesting only limited denaturation of camel whey proteins at higher inlet temperatures of drying. Thus, the effects of SD under the conditions applied in our study did not decrease camel whey protein solubility, while drying procedure itself regardless of temperature decreased solubility of camel milk caseins. MR generated during CM processing could be an important means of compensating for the lack of antioxidant protection normally associated with β-lactoglobulin but happens to be absent from this milk.",
publisher = "Elsevier",
journal = "LWT",
title = "Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying",
volume = "143",
pages = "111091",
doi = "10.1016/j.lwt.2021.111091"
}

Peruško, M., Ghnimi, S., Simović, A., Stevanović, N. R., Radomirović, M. Ž., Gharsallaoui, A., Smiljanić, K., Van Haute, S., Stanić-Vučinić, D.,& Ćirković-Veličković, T.. (2021). Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying. in LWT
Elsevier., 143, 111091.
https://doi.org/10.1016/j.lwt.2021.111091

Peruško M, Ghnimi S, Simović A, Stevanović NR, Radomirović MŽ, Gharsallaoui A, Smiljanić K, Van Haute S, Stanić-Vučinić D, Ćirković-Veličković T. Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying. in LWT. 2021;143:111091.
doi:10.1016/j.lwt.2021.111091 .

Peruško, Marija, Ghnimi, Sami, Simović, Ana, Stevanović, Nikola R., Radomirović, Mirjana Ž., Gharsallaoui, Adem, Smiljanić, Katarina, Van Haute, Sam, Stanić-Vučinić, Dragana, Ćirković-Veličković, Tanja, "Maillard reaction products formation and antioxidative power of spray dried camel milk powders increases with the inlet temperature of drying" in LWT, 143 (2021):111091,
https://doi.org/10.1016/j.lwt.2021.111091 . .

TY  - JOUR
AU  - Khulal, Urmila
AU  - Ghnimi, Sami
AU  - Stevanović, Nikola R.
AU  - Rajković, Andreja
AU  - Ćirković-Veličković, Tanja
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4746
AB  - In this work, we observed the effect of grape juice (% concentrated juice/% concentrated camel milk: GJ20/80, GJ50/50) and pomegranate juice (PJ20/80, PJ40/60) fortification on camel milk (CM) protein solubility and digestibility. Proteins were dissolved in sodium phosphate buffer to 50 mg/ml and defatted prior Bradford assay of protein concentration, then analyzed by Size Exclusion-Ultra High-Performance Liquid chromatography (SE-UHPLC). The CM protein aggregation and their stability were further monitored at different pH 2.0, 4.0, and 7.5 via sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Freeze dried CM (FDCM) was the reference sample and our results showed that GJ50/50 and PJ40/60 with the highest fruit juice ratio had the lowest protein content in the supernatant, hence the decreased solubility. SE-UHPLC of supernatants showed a slight decrease in retention times of 11 kDa and 62 kDa proteins for GJ50/50 and PJ40/60 suggesting a possibility of adduct formation due to fortification leading to higher molecular weight. The simulated static in vitro gastrointestinal digestion of samples revealed that most soluble proteins were readily digested by pepsin, trypsin and chymotrypsin enzymes leading to small peptides. However, the SDS PAGE of pellets showed the partial resistance of casein and α-lactalbumin against peptic digestion.
PB  - Elsevier
T2  - LWT
T1  - Aggregability and digestibility study of fruit juice fortified camel milk powder proteins
VL  - 152
SP  - 112250
DO  - 10.1016/j.lwt.2021.112250
ER  - 

@article{
author = "Khulal, Urmila and Ghnimi, Sami and Stevanović, Nikola R. and Rajković, Andreja and Ćirković-Veličković, Tanja",
year = "2021",
abstract = "In this work, we observed the effect of grape juice (% concentrated juice/% concentrated camel milk: GJ20/80, GJ50/50) and pomegranate juice (PJ20/80, PJ40/60) fortification on camel milk (CM) protein solubility and digestibility. Proteins were dissolved in sodium phosphate buffer to 50 mg/ml and defatted prior Bradford assay of protein concentration, then analyzed by Size Exclusion-Ultra High-Performance Liquid chromatography (SE-UHPLC). The CM protein aggregation and their stability were further monitored at different pH 2.0, 4.0, and 7.5 via sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Freeze dried CM (FDCM) was the reference sample and our results showed that GJ50/50 and PJ40/60 with the highest fruit juice ratio had the lowest protein content in the supernatant, hence the decreased solubility. SE-UHPLC of supernatants showed a slight decrease in retention times of 11 kDa and 62 kDa proteins for GJ50/50 and PJ40/60 suggesting a possibility of adduct formation due to fortification leading to higher molecular weight. The simulated static in vitro gastrointestinal digestion of samples revealed that most soluble proteins were readily digested by pepsin, trypsin and chymotrypsin enzymes leading to small peptides. However, the SDS PAGE of pellets showed the partial resistance of casein and α-lactalbumin against peptic digestion.",
publisher = "Elsevier",
journal = "LWT",
title = "Aggregability and digestibility study of fruit juice fortified camel milk powder proteins",
volume = "152",
pages = "112250",
doi = "10.1016/j.lwt.2021.112250"
}

Khulal, U., Ghnimi, S., Stevanović, N. R., Rajković, A.,& Ćirković-Veličković, T.. (2021). Aggregability and digestibility study of fruit juice fortified camel milk powder proteins. in LWT
Elsevier., 152, 112250.
https://doi.org/10.1016/j.lwt.2021.112250

Khulal U, Ghnimi S, Stevanović NR, Rajković A, Ćirković-Veličković T. Aggregability and digestibility study of fruit juice fortified camel milk powder proteins. in LWT. 2021;152:112250.
doi:10.1016/j.lwt.2021.112250 .

Khulal, Urmila, Ghnimi, Sami, Stevanović, Nikola R., Rajković, Andreja, Ćirković-Veličković, Tanja, "Aggregability and digestibility study of fruit juice fortified camel milk powder proteins" in LWT, 152 (2021):112250,
https://doi.org/10.1016/j.lwt.2021.112250 . .

TY  - CONF
AU  - Peruško, Marija
AU  - Simović, Ana
AU  - Stevanović, Nikola R.
AU  - Radomirović, Mirjana Ž.
AU  - Smiljanić, Katarina
AU  - Stanić-Vučinić, Dragana
AU  - Ghnimi, Sami
AU  - Ćirković-Veličković, Tanja
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5130
AB  - Objective. Camel milk is highly nutritious food with many health benefits proposed. Demand for camel milk has increased worldwide. Production of camel milk powders facilitate its transport, prolonge shelf-life, and also offer an attractive additive for various food products. In this study we examined the effect of freeze/spray drying treatment for camel milk powder production, on physiochemical and functional properties of camel milk proteins.
Material and Methods. Whole camel milk powders were prepared by spray drying treatment at six different inlet temperatures (190°C - 250°C) or by freeze drying. The soluble protein fractions upon the treatments were analysed by combination of electrophoretic and spectroscopic techniques. Structural and functional properties of camel milk proteins such as Maillard reaction products formation, antioxidant activity and protein solubility were assessed.
Results. SDS-PAGE revealed non-uniform increase in Mw of major protein bands, while native electrophoresis revealed non-uniform decrease in pI values with increased inlet temperature of spray drying. That indicated attachement of lactose moieties to NH2-group of proteins via non-enzymatic Maillard reaction. Spectrophotometric analysis showed formation of intermediate Maillard reaction products (increased absorbance at 294 nm) and no detectable late Maillard reaction products formation. Higher inlet temperatures (230°C - 250°C) resulted in higher protein carbonyls formation and lower content of free amino groups as a result of Maillard reaction. Far-UV circular dichroism spectra showed no differences in secondary structures between freeze and spray dried samples. Antioxidant activity and protein solubility were increased with increase in inlet temperature.
Conclusions. Our results showed that spray drying treatment promotes non-enzymatic glycation of camel milk proteins and exert significant effects on the techno-functional properties of CM powder such as nutritional value and shelf life. Thus, optimization of spray drying parametars is essential for production of high quality camel milk powders.
Acknowledgments: This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant number 172024. The project leading to this application has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 810752.
C3  - 2nd FoodEnTwin Workshop Experimental anlimal models for food and environment, February 3-4, 2020, Vienna, Austria
T1  - Higher degree of Maillard reaction induced by spray drying at high temperatures increases antioxidant activity of camel milk proteins
SP  - 6
EP  - 7
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5130
ER  - 

@conference{
author = "Peruško, Marija and Simović, Ana and Stevanović, Nikola R. and Radomirović, Mirjana Ž. and Smiljanić, Katarina and Stanić-Vučinić, Dragana and Ghnimi, Sami and Ćirković-Veličković, Tanja",
year = "2020",
abstract = "Objective. Camel milk is highly nutritious food with many health benefits proposed. Demand for camel milk has increased worldwide. Production of camel milk powders facilitate its transport, prolonge shelf-life, and also offer an attractive additive for various food products. In this study we examined the effect of freeze/spray drying treatment for camel milk powder production, on physiochemical and functional properties of camel milk proteins.
Material and Methods. Whole camel milk powders were prepared by spray drying treatment at six different inlet temperatures (190°C - 250°C) or by freeze drying. The soluble protein fractions upon the treatments were analysed by combination of electrophoretic and spectroscopic techniques. Structural and functional properties of camel milk proteins such as Maillard reaction products formation, antioxidant activity and protein solubility were assessed.
Results. SDS-PAGE revealed non-uniform increase in Mw of major protein bands, while native electrophoresis revealed non-uniform decrease in pI values with increased inlet temperature of spray drying. That indicated attachement of lactose moieties to NH2-group of proteins via non-enzymatic Maillard reaction. Spectrophotometric analysis showed formation of intermediate Maillard reaction products (increased absorbance at 294 nm) and no detectable late Maillard reaction products formation. Higher inlet temperatures (230°C - 250°C) resulted in higher protein carbonyls formation and lower content of free amino groups as a result of Maillard reaction. Far-UV circular dichroism spectra showed no differences in secondary structures between freeze and spray dried samples. Antioxidant activity and protein solubility were increased with increase in inlet temperature.
Conclusions. Our results showed that spray drying treatment promotes non-enzymatic glycation of camel milk proteins and exert significant effects on the techno-functional properties of CM powder such as nutritional value and shelf life. Thus, optimization of spray drying parametars is essential for production of high quality camel milk powders.
Acknowledgments: This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant number 172024. The project leading to this application has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 810752.",
journal = "2nd FoodEnTwin Workshop Experimental anlimal models for food and environment, February 3-4, 2020, Vienna, Austria",
title = "Higher degree of Maillard reaction induced by spray drying at high temperatures increases antioxidant activity of camel milk proteins",
pages = "6-7",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5130"
}

Peruško, M., Simović, A., Stevanović, N. R., Radomirović, M. Ž., Smiljanić, K., Stanić-Vučinić, D., Ghnimi, S.,& Ćirković-Veličković, T.. (2020). Higher degree of Maillard reaction induced by spray drying at high temperatures increases antioxidant activity of camel milk proteins. in 2nd FoodEnTwin Workshop Experimental anlimal models for food and environment, February 3-4, 2020, Vienna, Austria, 6-7.
https://hdl.handle.net/21.15107/rcub_cherry_5130

Peruško M, Simović A, Stevanović NR, Radomirović MŽ, Smiljanić K, Stanić-Vučinić D, Ghnimi S, Ćirković-Veličković T. Higher degree of Maillard reaction induced by spray drying at high temperatures increases antioxidant activity of camel milk proteins. in 2nd FoodEnTwin Workshop Experimental anlimal models for food and environment, February 3-4, 2020, Vienna, Austria. 2020;:6-7.
https://hdl.handle.net/21.15107/rcub_cherry_5130 .

Peruško, Marija, Simović, Ana, Stevanović, Nikola R., Radomirović, Mirjana Ž., Smiljanić, Katarina, Stanić-Vučinić, Dragana, Ghnimi, Sami, Ćirković-Veličković, Tanja, "Higher degree of Maillard reaction induced by spray drying at high temperatures increases antioxidant activity of camel milk proteins" in 2nd FoodEnTwin Workshop Experimental anlimal models for food and environment, February 3-4, 2020, Vienna, Austria (2020):6-7,
https://hdl.handle.net/21.15107/rcub_cherry_5130 .

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Kovačević, Gordana
AU  - Stanković, Dalibor
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3976
AB  - A new glucose biosensor for selective and sensitive determination of glucose in beverage samples was developed. A copper complex with a Schiff base, N,N’-bis(acetylacetonato) propylenediimine, was used as a mediator. It was mixed with glucose oxidase (GOx) and prepared as carbon paste electrode (CPE). Cyclic voltammetry was used for electrochemical measurements. The biosensor showed improved sensitivity when enzyme mediator ratio was 1 : 5, and working pH was 6.6 in 0.1 M phosphate buffer. The linear response of the biosensor for glucose concentration was in the range from 0.5 to 10 mM, with low detection limit of 0.36 mM (calculated as 3 s/n) and sensitivity of 0.16 μA/mM. The reproducibility of the biosensor, calculated as relative standard deviation, was 1.9% for 6 intra-day measurements. Biosensor was stored at +4 °C between experiments, and it was stable during 14 days after the preparation. The developed biosensor was applied on determination of glucose in commercial beverages (apple and cherry juice) and obtained results showed good agreement with the reference method.
PB  - Wiley-Blackwell
T2  - ChemistrySelect
T1  - Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor
VL  - 5
IS  - 5
SP  - 1671
EP  - 1675
DO  - 10.1002/slct.201904873
ER  - 

@article{
author = "Perušković, Danica S. and Stevanović, Nikola R. and Kovačević, Gordana and Stanković, Dalibor and Lolić, Aleksandar and Baošić, Rada",
year = "2020",
abstract = "A new glucose biosensor for selective and sensitive determination of glucose in beverage samples was developed. A copper complex with a Schiff base, N,N’-bis(acetylacetonato) propylenediimine, was used as a mediator. It was mixed with glucose oxidase (GOx) and prepared as carbon paste electrode (CPE). Cyclic voltammetry was used for electrochemical measurements. The biosensor showed improved sensitivity when enzyme mediator ratio was 1 : 5, and working pH was 6.6 in 0.1 M phosphate buffer. The linear response of the biosensor for glucose concentration was in the range from 0.5 to 10 mM, with low detection limit of 0.36 mM (calculated as 3 s/n) and sensitivity of 0.16 μA/mM. The reproducibility of the biosensor, calculated as relative standard deviation, was 1.9% for 6 intra-day measurements. Biosensor was stored at +4 °C between experiments, and it was stable during 14 days after the preparation. The developed biosensor was applied on determination of glucose in commercial beverages (apple and cherry juice) and obtained results showed good agreement with the reference method.",
publisher = "Wiley-Blackwell",
journal = "ChemistrySelect",
title = "Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor",
volume = "5",
number = "5",
pages = "1671-1675",
doi = "10.1002/slct.201904873"
}

Perušković, D. S., Stevanović, N. R., Kovačević, G., Stanković, D., Lolić, A.,& Baošić, R.. (2020). Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor. in ChemistrySelect
Wiley-Blackwell., 5(5), 1671-1675.
https://doi.org/10.1002/slct.201904873

Perušković DS, Stevanović NR, Kovačević G, Stanković D, Lolić A, Baošić R. Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor. in ChemistrySelect. 2020;5(5):1671-1675.
doi:10.1002/slct.201904873 .

Perušković, Danica S., Stevanović, Nikola R., Kovačević, Gordana, Stanković, Dalibor, Lolić, Aleksandar, Baošić, Rada, "Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor" in ChemistrySelect, 5, no. 5 (2020):1671-1675,
https://doi.org/10.1002/slct.201904873 . .

TY  - CONF
AU  - Peruško, Marija
AU  - Simović, Ana
AU  - Stevanović, Nikola R.
AU  - Smiljanić, Katarina
AU  - Radomirović, Mirjana Ž.
AU  - Stanić-Vučinić, Dragana
AU  - Ghnimi, Sami
AU  - Ćirković-Veličković, Tanja
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5131
AB  - Objective. Camel milk is highly nutritious food with numerous health benefits
proposed. Demand for camel milk has increased worldwide. Production of camel milk
powders facilitate its transport, prolonge shelf-life, and also offer an attractive additive
for various food products. In this study we characterized proteins of soluble fraction of
freeze/spray dried camel milk powders.
Material and Methods. Whole camel milk powders were prepared by spray drying
treatment at six different inlet temperatures (190°C - 250°C) or by freeze drying. The
soluble protein fractions upon the treatments were analysed by combination of
electrophoretic and spectroscopic techniques. Functional properties, such as
antioxidant activity and protein solubility were assessed.
Results. SDS-PAGE revealed non-uniform increase in Mw of major protein bands, while
native electrophoresis revealed non-uniform decrease in pI values with increased inlet
temperature of spray drying. That indicated attachement of lactose moieties to NH2-
group of proteins via non-enzymatic Maillard reaction. Spectrophotometric analysis
showed formation of intermediate Maillard reaction products (increased absorbance at
294 nm) and no detectable late Maillard reaction products formation. Far-UV circular
dichroism spectra showed no differences in secondary structures between freeze and
spray dried samples. Antioxidant activity and protein solubility were increased with
increase in inlet temperature.
Conclusions. Our results showed that spray drying treatment promoted non-enzymatic
glycation of camel milk proteins. Glycation of food proteins affects their technofunctional
properties, shelf-life and nutritional value. Thus, optimization of spray
drying parametars is essential for production of high quality camel milk powders.
Acknowledgements: This research work was funded the Ministry of Education and Science of the Republic
of Serbia, GA No. OI172024, Ghent University Global Campus, Belgian Special Research Fund BOF StG No.
01N01718, Serbian Academy of Sciences and Arts Project F-26. The project leading to this application
has received funding from the European Union's Horizon 2020 research and innovation programme under
grant agreement No 810752.
C3  - 1st FoodEnTwin Workshop “Food and Environmental -Omics”, Book of Abstracts, June 20-21, 2019, Belgrade, Serbia
T1  - Physicochemical characterization of soluble proteins of whole camel milk powders produced by spray drying treatment at high temperatures
SP  - 27
EP  - 27
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5131
ER  - 

@conference{
author = "Peruško, Marija and Simović, Ana and Stevanović, Nikola R. and Smiljanić, Katarina and Radomirović, Mirjana Ž. and Stanić-Vučinić, Dragana and Ghnimi, Sami and Ćirković-Veličković, Tanja",
year = "2019",
abstract = "Objective. Camel milk is highly nutritious food with numerous health benefits
proposed. Demand for camel milk has increased worldwide. Production of camel milk
powders facilitate its transport, prolonge shelf-life, and also offer an attractive additive
for various food products. In this study we characterized proteins of soluble fraction of
freeze/spray dried camel milk powders.
Material and Methods. Whole camel milk powders were prepared by spray drying
treatment at six different inlet temperatures (190°C - 250°C) or by freeze drying. The
soluble protein fractions upon the treatments were analysed by combination of
electrophoretic and spectroscopic techniques. Functional properties, such as
antioxidant activity and protein solubility were assessed.
Results. SDS-PAGE revealed non-uniform increase in Mw of major protein bands, while
native electrophoresis revealed non-uniform decrease in pI values with increased inlet
temperature of spray drying. That indicated attachement of lactose moieties to NH2-
group of proteins via non-enzymatic Maillard reaction. Spectrophotometric analysis
showed formation of intermediate Maillard reaction products (increased absorbance at
294 nm) and no detectable late Maillard reaction products formation. Far-UV circular
dichroism spectra showed no differences in secondary structures between freeze and
spray dried samples. Antioxidant activity and protein solubility were increased with
increase in inlet temperature.
Conclusions. Our results showed that spray drying treatment promoted non-enzymatic
glycation of camel milk proteins. Glycation of food proteins affects their technofunctional
properties, shelf-life and nutritional value. Thus, optimization of spray
drying parametars is essential for production of high quality camel milk powders.
Acknowledgements: This research work was funded the Ministry of Education and Science of the Republic
of Serbia, GA No. OI172024, Ghent University Global Campus, Belgian Special Research Fund BOF StG No.
01N01718, Serbian Academy of Sciences and Arts Project F-26. The project leading to this application
has received funding from the European Union's Horizon 2020 research and innovation programme under
grant agreement No 810752.",
journal = "1st FoodEnTwin Workshop “Food and Environmental -Omics”, Book of Abstracts, June 20-21, 2019, Belgrade, Serbia",
title = "Physicochemical characterization of soluble proteins of whole camel milk powders produced by spray drying treatment at high temperatures",
pages = "27-27",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5131"
}

Peruško, M., Simović, A., Stevanović, N. R., Smiljanić, K., Radomirović, M. Ž., Stanić-Vučinić, D., Ghnimi, S.,& Ćirković-Veličković, T.. (2019). Physicochemical characterization of soluble proteins of whole camel milk powders produced by spray drying treatment at high temperatures. in 1st FoodEnTwin Workshop “Food and Environmental -Omics”, Book of Abstracts, June 20-21, 2019, Belgrade, Serbia, 27-27.
https://hdl.handle.net/21.15107/rcub_cherry_5131

Peruško M, Simović A, Stevanović NR, Smiljanić K, Radomirović MŽ, Stanić-Vučinić D, Ghnimi S, Ćirković-Veličković T. Physicochemical characterization of soluble proteins of whole camel milk powders produced by spray drying treatment at high temperatures. in 1st FoodEnTwin Workshop “Food and Environmental -Omics”, Book of Abstracts, June 20-21, 2019, Belgrade, Serbia. 2019;:27-27.
https://hdl.handle.net/21.15107/rcub_cherry_5131 .

Peruško, Marija, Simović, Ana, Stevanović, Nikola R., Smiljanić, Katarina, Radomirović, Mirjana Ž., Stanić-Vučinić, Dragana, Ghnimi, Sami, Ćirković-Veličković, Tanja, "Physicochemical characterization of soluble proteins of whole camel milk powders produced by spray drying treatment at high temperatures" in 1st FoodEnTwin Workshop “Food and Environmental -Omics”, Book of Abstracts, June 20-21, 2019, Belgrade, Serbia (2019):27-27,
https://hdl.handle.net/21.15107/rcub_cherry_5131 .

TY  - JOUR
AU  - Filipović, Dragana
AU  - Gašić, Uroš M.
AU  - Stevanović, Nikola R.
AU  - Dabić Zagorac, Dragana
AU  - Fotirić-Akšić, Milica M.
AU  - Natić, Maja
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2160
AB  - The carbon stable isotope content of Cornelian cherry stones collected from wild tree stands in Serbia, SE Europe, was measured using elemental analyser-isotope ratio mass spectrometry, with the aim of recording natural carbon isotope composition of the fruit stones and its possible variation. The results show a significant variation in the carbon isotope values; we identified several environmental factors that, along with a number of other possible determinants, likely contributed to this variation. The obtained data are compared with the measurement of carbon isotope content of an archaeological specimen of Cornelian cherry stone discovered at the Neolithic site of Vina (ca. 5600-4500 BC) in Serbia. Notwithstanding the limitedness of the data and the complexity surrounding carbon fractionation and the isotopic variation, it is suggested that the differences/similarities in carbon isotope ratios between modern and archaeological Cornelian cherry stones, when measured for much larger assemblages, could potentially offer a glimpse into growing conditions of Cornelian cherry trees in the past.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Isotopes in Environmental and Health Studies
T1  - Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study
VL  - 54
IS  - 4
SP  - 337
EP  - 351
DO  - 10.1080/10256016.2017.1392516
ER  - 

@article{
author = "Filipović, Dragana and Gašić, Uroš M. and Stevanović, Nikola R. and Dabić Zagorac, Dragana and Fotirić-Akšić, Milica M. and Natić, Maja",
year = "2018",
abstract = "The carbon stable isotope content of Cornelian cherry stones collected from wild tree stands in Serbia, SE Europe, was measured using elemental analyser-isotope ratio mass spectrometry, with the aim of recording natural carbon isotope composition of the fruit stones and its possible variation. The results show a significant variation in the carbon isotope values; we identified several environmental factors that, along with a number of other possible determinants, likely contributed to this variation. The obtained data are compared with the measurement of carbon isotope content of an archaeological specimen of Cornelian cherry stone discovered at the Neolithic site of Vina (ca. 5600-4500 BC) in Serbia. Notwithstanding the limitedness of the data and the complexity surrounding carbon fractionation and the isotopic variation, it is suggested that the differences/similarities in carbon isotope ratios between modern and archaeological Cornelian cherry stones, when measured for much larger assemblages, could potentially offer a glimpse into growing conditions of Cornelian cherry trees in the past.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Isotopes in Environmental and Health Studies",
title = "Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study",
volume = "54",
number = "4",
pages = "337-351",
doi = "10.1080/10256016.2017.1392516"
}

Filipović, D., Gašić, U. M., Stevanović, N. R., Dabić Zagorac, D., Fotirić-Akšić, M. M.,& Natić, M.. (2018). Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study. in Isotopes in Environmental and Health Studies
Taylor & Francis Ltd, Abingdon., 54(4), 337-351.
https://doi.org/10.1080/10256016.2017.1392516

Filipović D, Gašić UM, Stevanović NR, Dabić Zagorac D, Fotirić-Akšić MM, Natić M. Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study. in Isotopes in Environmental and Health Studies. 2018;54(4):337-351.
doi:10.1080/10256016.2017.1392516 .

Filipović, Dragana, Gašić, Uroš M., Stevanović, Nikola R., Dabić Zagorac, Dragana, Fotirić-Akšić, Milica M., Natić, Maja, "Carbon stable isotope composition of modern and archaeological Cornelian cherry fruit stones: a pilot study" in Isotopes in Environmental and Health Studies, 54, no. 4 (2018):337-351,
https://doi.org/10.1080/10256016.2017.1392516 . .

TY  - JOUR
AU  - Kojić, Ivan
AU  - Bechtel, Achim
AU  - Kittinger, Friedrich
AU  - Stevanović, Nikola R.
AU  - Obradović, Marko
AU  - Stojanović, Ksenija A.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2201
AB  - Pyrolysis of high density polyethylene (HDPE) in the open system was studied. A plastic bag for food packing was used as a source of HDPE. Pyrolysis was performed at temperatures of 400, 450 and 500 degrees C, which were chosen based on thermogravimetric analysis. The HDPE pyrolysis yielded liquid, gaseous and solid products. Temperature rise resulted in the increase of conversion of HDPE into liquid and gaseous products. The main constituents of liquid pyrolysates are 1-n-alkenes, n-alkanes and terminal n-dienes. The composition of liquid products indicates that the performed pyrolysis of HDPE could not serve as a standalone operation for the production of gasoline or diesel, but preferably as a pre-treatment to yield a product to be blended into a refinery or petrochemical feed stream. The advantage of a liquid pyrolysate in comparison to crude oil is the extremely low content of aromatic hydrocarbons and the absence of polar compounds. The gaseous products have desirable composition and consist mainly of methane and ethene. The solid residues do not produce ash by combustion and have high calorific values. Co-pyrolysis of HDPE with mineral-rich lignite indicated positive synergetic effect at 450 and 500 degrees C, which is reflected through the increased experimental yields of liquid and gaseous products in comparison to theoretical ones.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Study of pyrolysis of high density polyethylene in the open system and estimation of its capability for co-pyrolysis with lignite
VL  - 83
IS  - 7-8
SP  - 923
EP  - 940
DO  - 10.2298/JSC171215027K
ER  - 

@article{
author = "Kojić, Ivan and Bechtel, Achim and Kittinger, Friedrich and Stevanović, Nikola R. and Obradović, Marko and Stojanović, Ksenija A.",
year = "2018",
abstract = "Pyrolysis of high density polyethylene (HDPE) in the open system was studied. A plastic bag for food packing was used as a source of HDPE. Pyrolysis was performed at temperatures of 400, 450 and 500 degrees C, which were chosen based on thermogravimetric analysis. The HDPE pyrolysis yielded liquid, gaseous and solid products. Temperature rise resulted in the increase of conversion of HDPE into liquid and gaseous products. The main constituents of liquid pyrolysates are 1-n-alkenes, n-alkanes and terminal n-dienes. The composition of liquid products indicates that the performed pyrolysis of HDPE could not serve as a standalone operation for the production of gasoline or diesel, but preferably as a pre-treatment to yield a product to be blended into a refinery or petrochemical feed stream. The advantage of a liquid pyrolysate in comparison to crude oil is the extremely low content of aromatic hydrocarbons and the absence of polar compounds. The gaseous products have desirable composition and consist mainly of methane and ethene. The solid residues do not produce ash by combustion and have high calorific values. Co-pyrolysis of HDPE with mineral-rich lignite indicated positive synergetic effect at 450 and 500 degrees C, which is reflected through the increased experimental yields of liquid and gaseous products in comparison to theoretical ones.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Study of pyrolysis of high density polyethylene in the open system and estimation of its capability for co-pyrolysis with lignite",
volume = "83",
number = "7-8",
pages = "923-940",
doi = "10.2298/JSC171215027K"
}

Kojić, I., Bechtel, A., Kittinger, F., Stevanović, N. R., Obradović, M.,& Stojanović, K. A.. (2018). Study of pyrolysis of high density polyethylene in the open system and estimation of its capability for co-pyrolysis with lignite. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 83(7-8), 923-940.
https://doi.org/10.2298/JSC171215027K

Kojić I, Bechtel A, Kittinger F, Stevanović NR, Obradović M, Stojanović KA. Study of pyrolysis of high density polyethylene in the open system and estimation of its capability for co-pyrolysis with lignite. in Journal of the Serbian Chemical Society. 2018;83(7-8):923-940.
doi:10.2298/JSC171215027K .

Kojić, Ivan, Bechtel, Achim, Kittinger, Friedrich, Stevanović, Nikola R., Obradović, Marko, Stojanović, Ksenija A., "Study of pyrolysis of high density polyethylene in the open system and estimation of its capability for co-pyrolysis with lignite" in Journal of the Serbian Chemical Society, 83, no. 7-8 (2018):923-940,
https://doi.org/10.2298/JSC171215027K . .

TY  - DATA
AU  - Kojić, Ivan
AU  - Bechtel, Achim
AU  - Kittinger, Friedrich
AU  - Stevanović, Nikola R.
AU  - Obradović, Marko
AU  - Stojanović, Ksenija A.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3306
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary data for the article: Kojic, I.; Bechtel, A.; Kittinger, F.; Stevanovic, N.; Obradovic, M.; Stojanovic, K. Study of Pyrolysis of High Density Polyethylene in the Open System and Estimation of Its Capability for Co-Pyrolysis with Lignite. J. Serb. Chem. Soc. 2018, 83 (7–8), 923–940. https://doi.org/10.2298/JSC171215027K
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3306
ER  - 

@misc{
author = "Kojić, Ivan and Bechtel, Achim and Kittinger, Friedrich and Stevanović, Nikola R. and Obradović, Marko and Stojanović, Ksenija A.",
year = "2018",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary data for the article: Kojic, I.; Bechtel, A.; Kittinger, F.; Stevanovic, N.; Obradovic, M.; Stojanovic, K. Study of Pyrolysis of High Density Polyethylene in the Open System and Estimation of Its Capability for Co-Pyrolysis with Lignite. J. Serb. Chem. Soc. 2018, 83 (7–8), 923–940. https://doi.org/10.2298/JSC171215027K",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3306"
}

Kojić, I., Bechtel, A., Kittinger, F., Stevanović, N. R., Obradović, M.,& Stojanović, K. A.. (2018). Supplementary data for the article: Kojic, I.; Bechtel, A.; Kittinger, F.; Stevanovic, N.; Obradovic, M.; Stojanovic, K. Study of Pyrolysis of High Density Polyethylene in the Open System and Estimation of Its Capability for Co-Pyrolysis with Lignite. J. Serb. Chem. Soc. 2018, 83 (7–8), 923–940. https://doi.org/10.2298/JSC171215027K. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade..
https://hdl.handle.net/21.15107/rcub_cherry_3306

Kojić I, Bechtel A, Kittinger F, Stevanović NR, Obradović M, Stojanović KA. Supplementary data for the article: Kojic, I.; Bechtel, A.; Kittinger, F.; Stevanovic, N.; Obradovic, M.; Stojanovic, K. Study of Pyrolysis of High Density Polyethylene in the Open System and Estimation of Its Capability for Co-Pyrolysis with Lignite. J. Serb. Chem. Soc. 2018, 83 (7–8), 923–940. https://doi.org/10.2298/JSC171215027K. in Journal of the Serbian Chemical Society. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3306 .

Kojić, Ivan, Bechtel, Achim, Kittinger, Friedrich, Stevanović, Nikola R., Obradović, Marko, Stojanović, Ksenija A., "Supplementary data for the article: Kojic, I.; Bechtel, A.; Kittinger, F.; Stevanovic, N.; Obradovic, M.; Stojanovic, K. Study of Pyrolysis of High Density Polyethylene in the Open System and Estimation of Its Capability for Co-Pyrolysis with Lignite. J. Serb. Chem. Soc. 2018, 83 (7–8), 923–940. https://doi.org/10.2298/JSC171215027K" in Journal of the Serbian Chemical Society (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3306 .

TY  - JOUR
AU  - Antunović, Vesna R.
AU  - Tešanović, Slavna
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Baošić, Rada
AU  - Mandić, Snežana D.
AU  - Lolić, Aleksandar
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2122
AB  - The is work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen. The thin flow cell consisted of the bare glassy carbon electrode, reference silver/silver chloride, and stainless steel as the auxiliary electrode. Electrochemical reduction of diazepam (DZP) was characterised by cyclic voltammetry. Azomethine reduction peak was used for DZP quantification. The detector response was linear in the range 20-250 mu mol/dm(3) of diazepam, with a calculated detection limit of 3.83 mu g/cm(3). Intraday and interday precision were 1.53 and 10.8%, respectively. The method was applied on three beverage samples, energetic drink, and two different beer samples, and obtained recoveries were from 93.65 up to 104.96%. The throughoutput of the method was up to 90 analyses per hour.
PB  - Hindawi Ltd, London
T2  - Journal of Analytical Methods in Chemistry
T1  - Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination
DO  - 10.1155/2018/6121489
ER  - 

@article{
author = "Antunović, Vesna R. and Tešanović, Slavna and Perušković, Danica S. and Stevanović, Nikola R. and Baošić, Rada and Mandić, Snežana D. and Lolić, Aleksandar",
year = "2018",
abstract = "The is work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen. The thin flow cell consisted of the bare glassy carbon electrode, reference silver/silver chloride, and stainless steel as the auxiliary electrode. Electrochemical reduction of diazepam (DZP) was characterised by cyclic voltammetry. Azomethine reduction peak was used for DZP quantification. The detector response was linear in the range 20-250 mu mol/dm(3) of diazepam, with a calculated detection limit of 3.83 mu g/cm(3). Intraday and interday precision were 1.53 and 10.8%, respectively. The method was applied on three beverage samples, energetic drink, and two different beer samples, and obtained recoveries were from 93.65 up to 104.96%. The throughoutput of the method was up to 90 analyses per hour.",
publisher = "Hindawi Ltd, London",
journal = "Journal of Analytical Methods in Chemistry",
title = "Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination",
doi = "10.1155/2018/6121489"
}

Antunović, V. R., Tešanović, S., Perušković, D. S., Stevanović, N. R., Baošić, R., Mandić, S. D.,& Lolić, A.. (2018). Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination. in Journal of Analytical Methods in Chemistry
Hindawi Ltd, London..
https://doi.org/10.1155/2018/6121489

Antunović VR, Tešanović S, Perušković DS, Stevanović NR, Baošić R, Mandić SD, Lolić A. Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination. in Journal of Analytical Methods in Chemistry. 2018;.
doi:10.1155/2018/6121489 .

Antunović, Vesna R., Tešanović, Slavna, Perušković, Danica S., Stevanović, Nikola R., Baošić, Rada, Mandić, Snežana D., Lolić, Aleksandar, "Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination" in Journal of Analytical Methods in Chemistry (2018),
https://doi.org/10.1155/2018/6121489 . .

TY  - THES
AU  - Stevanović, Nikola R.
PY  - 2018
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5669
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:17339/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49966607
UR  - http://nardus.mpn.gov.rs/123456789/16159
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2758
AB  - Šifove baze i njihovi kompleksi pokazuju različitu biološku aktivnost poput antiviralne, antimikrobne, antimalarijske i antikancerske. Zbog činjenice da biološka aktivnost jedinjenja zavisi prvenstveno od lipofilnosti molekula, što je posledica strukture jedinjenja, određivanje i korelacija lipofilnosti sa hemijskom strukturom, kao i određivanje biološke aktivnosti su postali nezaobilazni u sintezi novih lekova...
AB  - Schiff bases and their complexes are versatile compounds which have various biological activities such as antiviral, antimicrobial, antimalarial, and anticancer activity. Biological activity of compounds depends on their molecular structure, especially lipophilic character. Determination of lipophilicity, its correlation with chemical structure, and biological activity is very important in drug design...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Polidentatne Šifove baze i njihovi Cu(II) kompleksi: lipofilnost i biološka aktivnost
UR  - https://hdl.handle.net/21.15107/rcub_nardus_16159
ER  - 

@phdthesis{
author = "Stevanović, Nikola R.",
year = "2018",
abstract = "Šifove baze i njihovi kompleksi pokazuju različitu biološku aktivnost poput antiviralne, antimikrobne, antimalarijske i antikancerske. Zbog činjenice da biološka aktivnost jedinjenja zavisi prvenstveno od lipofilnosti molekula, što je posledica strukture jedinjenja, određivanje i korelacija lipofilnosti sa hemijskom strukturom, kao i određivanje biološke aktivnosti su postali nezaobilazni u sintezi novih lekova..., Schiff bases and their complexes are versatile compounds which have various biological activities such as antiviral, antimicrobial, antimalarial, and anticancer activity. Biological activity of compounds depends on their molecular structure, especially lipophilic character. Determination of lipophilicity, its correlation with chemical structure, and biological activity is very important in drug design...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Polidentatne Šifove baze i njihovi Cu(II) kompleksi: lipofilnost i biološka aktivnost",
url = "https://hdl.handle.net/21.15107/rcub_nardus_16159"
}

Stevanović, N. R.. (2018). Polidentatne Šifove baze i njihovi Cu(II) kompleksi: lipofilnost i biološka aktivnost. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_16159

Stevanović NR. Polidentatne Šifove baze i njihovi Cu(II) kompleksi: lipofilnost i biološka aktivnost. in Универзитет у Београду. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_16159 .

Stevanović, Nikola R., "Polidentatne Šifove baze i njihovi Cu(II) kompleksi: lipofilnost i biološka aktivnost" in Универзитет у Београду (2018),
https://hdl.handle.net/21.15107/rcub_nardus_16159 .

TY  - BOOK
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
AU  - Mutić, Jelena
AU  - Stevanović, Nikola R.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2888
PB  - Hemijski fakultet
T1  - Klasične metode kvantitativne hemijske analize
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2888
ER  - 

@book{
author = "Baošić, Rada and Lolić, Aleksandar and Mutić, Jelena and Stevanović, Nikola R.",
year = "2018",
publisher = "Hemijski fakultet",
title = "Klasične metode kvantitativne hemijske analize",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2888"
}

Baošić, R., Lolić, A., Mutić, J.,& Stevanović, N. R.. (2018). Klasične metode kvantitativne hemijske analize. 
Hemijski fakultet..
https://hdl.handle.net/21.15107/rcub_cherry_2888

Baošić R, Lolić A, Mutić J, Stevanović NR. Klasične metode kvantitativne hemijske analize. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_2888 .

Baošić, Rada, Lolić, Aleksandar, Mutić, Jelena, Stevanović, Nikola R., "Klasične metode kvantitativne hemijske analize" (2018),
https://hdl.handle.net/21.15107/rcub_cherry_2888 .

TY  - JOUR
AU  - Stevanović, Nikola R.
AU  - Perušković, Danica S.
AU  - Gašić, Uroš M.
AU  - Antunović, Vesna R.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2443
AB  - The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.
PB  - Wiley, Hoboken
T2  - Biomedical Chromatography
T1  - Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes
VL  - 31
IS  - 3
DO  - 10.1002/bmc.3810
ER  - 

@article{
author = "Stevanović, Nikola R. and Perušković, Danica S. and Gašić, Uroš M. and Antunović, Vesna R. and Lolić, Aleksandar and Baošić, Rada",
year = "2017",
abstract = "The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.",
publisher = "Wiley, Hoboken",
journal = "Biomedical Chromatography",
title = "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes",
volume = "31",
number = "3",
doi = "10.1002/bmc.3810"
}

Stevanović, N. R., Perušković, D. S., Gašić, U. M., Antunović, V. R., Lolić, A.,& Baošić, R.. (2017). Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography
Wiley, Hoboken., 31(3).
https://doi.org/10.1002/bmc.3810

Stevanović NR, Perušković DS, Gašić UM, Antunović VR, Lolić A, Baošić R. Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography. 2017;31(3).
doi:10.1002/bmc.3810 .

Stevanović, Nikola R., Perušković, Danica S., Gašić, Uroš M., Antunović, Vesna R., Lolić, Aleksandar, Baošić, Rada, "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes" in Biomedical Chromatography, 31, no. 3 (2017),
https://doi.org/10.1002/bmc.3810 . .

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Gašić, Uroš M.
AU  - Antunović, Vesna R.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
AU  - Stevanović, Nikola R.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2982
AB  - The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.
PB  - Wiley, Hoboken
T2  - Biomedical Chromatography
T1  - Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes
VL  - 31
IS  - 3
DO  - 10.1002/bmc.3810
ER  - 

@article{
author = "Perušković, Danica S. and Gašić, Uroš M. and Antunović, Vesna R. and Lolić, Aleksandar and Baošić, Rada and Stevanović, Nikola R.",
year = "2017",
abstract = "The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.",
publisher = "Wiley, Hoboken",
journal = "Biomedical Chromatography",
title = "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes",
volume = "31",
number = "3",
doi = "10.1002/bmc.3810"
}

Perušković, D. S., Gašić, U. M., Antunović, V. R., Lolić, A., Baošić, R.,& Stevanović, N. R.. (2017). Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography
Wiley, Hoboken., 31(3).
https://doi.org/10.1002/bmc.3810

Perušković DS, Gašić UM, Antunović VR, Lolić A, Baošić R, Stevanović NR. Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography. 2017;31(3).
doi:10.1002/bmc.3810 .

Perušković, Danica S., Gašić, Uroš M., Antunović, Vesna R., Lolić, Aleksandar, Baošić, Rada, Stevanović, Nikola R., "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes" in Biomedical Chromatography, 31, no. 3 (2017),
https://doi.org/10.1002/bmc.3810 . .

TY  - CONF
AU  - Lolić, Aleksandar
AU  - Antunović, Vesna R.
AU  - Tešanović, Slavna
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Baošić, Rada
AU  - Nikolić, Snežana
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4994
AB  - Diazepam belongs to the group of benzodiazepine drugs, and its consumption with alcohol enhances its sedative effect and absorption rate. That is why it is often used as “date rape drug” [1]. In our experiments we applied the flow injection system on diazepam determination on a bare glassy carbon electrode. The electrochemical determination of diazepam is based on reduction of the azomethine group yielding a dyhidrodiazepam. The single cathodic peak is caused by the reduction of diazepam by a two electron change. The reduction potential is highly dependent on pH value of the electrolyte, shifting to more negative potentials with higher pH [2].
PB  - ISEP Instituto Superior de Engenharia do Porto
C3  - 1st workshop on Electrochemistry Devices (Bio)Sensors, October 13-14, 2016, Porto, Portugal, Book of Abstracts pp 31
T1  - Determination of diazepam by flow-injection with amperometric detection in beverages
SP  - 37
EP  - 37
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4994
ER  - 

@conference{
author = "Lolić, Aleksandar and Antunović, Vesna R. and Tešanović, Slavna and Perušković, Danica S. and Stevanović, Nikola R. and Baošić, Rada and Nikolić, Snežana",
year = "2016",
abstract = "Diazepam belongs to the group of benzodiazepine drugs, and its consumption with alcohol enhances its sedative effect and absorption rate. That is why it is often used as “date rape drug” [1]. In our experiments we applied the flow injection system on diazepam determination on a bare glassy carbon electrode. The electrochemical determination of diazepam is based on reduction of the azomethine group yielding a dyhidrodiazepam. The single cathodic peak is caused by the reduction of diazepam by a two electron change. The reduction potential is highly dependent on pH value of the electrolyte, shifting to more negative potentials with higher pH [2].",
publisher = "ISEP Instituto Superior de Engenharia do Porto",
journal = "1st workshop on Electrochemistry Devices (Bio)Sensors, October 13-14, 2016, Porto, Portugal, Book of Abstracts pp 31",
title = "Determination of diazepam by flow-injection with amperometric detection in beverages",
pages = "37-37",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4994"
}

Lolić, A., Antunović, V. R., Tešanović, S., Perušković, D. S., Stevanović, N. R., Baošić, R.,& Nikolić, S.. (2016). Determination of diazepam by flow-injection with amperometric detection in beverages. in 1st workshop on Electrochemistry Devices (Bio)Sensors, October 13-14, 2016, Porto, Portugal, Book of Abstracts pp 31
ISEP Instituto Superior de Engenharia do Porto., 37-37.
https://hdl.handle.net/21.15107/rcub_cherry_4994

Lolić A, Antunović VR, Tešanović S, Perušković DS, Stevanović NR, Baošić R, Nikolić S. Determination of diazepam by flow-injection with amperometric detection in beverages. in 1st workshop on Electrochemistry Devices (Bio)Sensors, October 13-14, 2016, Porto, Portugal, Book of Abstracts pp 31. 2016;:37-37.
https://hdl.handle.net/21.15107/rcub_cherry_4994 .

Lolić, Aleksandar, Antunović, Vesna R., Tešanović, Slavna, Perušković, Danica S., Stevanović, Nikola R., Baošić, Rada, Nikolić, Snežana, "Determination of diazepam by flow-injection with amperometric detection in beverages" in 1st workshop on Electrochemistry Devices (Bio)Sensors, October 13-14, 2016, Porto, Portugal, Book of Abstracts pp 31 (2016):37-37,
https://hdl.handle.net/21.15107/rcub_cherry_4994 .

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Daric, Branka
AU  - Blagus, Anita
AU  - Stevanović, Nikola R.
AU  - Pavlović, Aleksandra V.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1894
AB  - The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer chromatography. In order to determine retention parameter as a measure of the lipophilicity of the tested compounds, three different binary solvent systems, composed of water and organic modifier (methanol, acetonitrile, and tetrahydrofuran), were used. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis. Principal component analysis was employed to reveal the most influential factors governing the lipophilicity of the investigated compounds. Finally, the influence of organic modifier on determination of lipophilicity parameters was discussed.
PB  - Springer Wien, Wien
T2  - Monatshefte Fur Chemie
T1  - Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases
VL  - 146
IS  - 1
SP  - 1
EP  - 6
DO  - 10.1007/s00706-014-1313-7
ER  - 

@article{
author = "Perušković, Danica S. and Daric, Branka and Blagus, Anita and Stevanović, Nikola R. and Pavlović, Aleksandra V. and Lolić, Aleksandar and Baošić, Rada",
year = "2015",
abstract = "The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer chromatography. In order to determine retention parameter as a measure of the lipophilicity of the tested compounds, three different binary solvent systems, composed of water and organic modifier (methanol, acetonitrile, and tetrahydrofuran), were used. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis. Principal component analysis was employed to reveal the most influential factors governing the lipophilicity of the investigated compounds. Finally, the influence of organic modifier on determination of lipophilicity parameters was discussed.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte Fur Chemie",
title = "Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases",
volume = "146",
number = "1",
pages = "1-6",
doi = "10.1007/s00706-014-1313-7"
}

Perušković, D. S., Daric, B., Blagus, A., Stevanović, N. R., Pavlović, A. V., Lolić, A.,& Baošić, R.. (2015). Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases. in Monatshefte Fur Chemie
Springer Wien, Wien., 146(1), 1-6.
https://doi.org/10.1007/s00706-014-1313-7

Perušković DS, Daric B, Blagus A, Stevanović NR, Pavlović AV, Lolić A, Baošić R. Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases. in Monatshefte Fur Chemie. 2015;146(1):1-6.
doi:10.1007/s00706-014-1313-7 .

Perušković, Danica S., Daric, Branka, Blagus, Anita, Stevanović, Nikola R., Pavlović, Aleksandra V., Lolić, Aleksandar, Baošić, Rada, "Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases" in Monatshefte Fur Chemie, 146, no. 1 (2015):1-6,
https://doi.org/10.1007/s00706-014-1313-7 . .

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Lolić, Aleksandar
AU  - Nikolić, Milan
AU  - Baošić, Rada
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4950
AB  - The retention behavior and lipophilicity parameters of some antiphychotics were determined using reversed-phase thin layer chromatography. Quantitative structure-activity relationships studies have been performed to correlate the molecular characteristics of observed compounds with their retention as well as with their chromatographically determinated lipophilicity parameters.
The effect of different organic modifiers (acetone, tetrahydrofuran, and methanol) has been studied. The retention of investigated compounds decreases linearly with increasing concentration of organic modifier. The chemical structures of the antipsychotics have been characterized by molecular descriptors which are calculated from the structure and related to chromatographically determinated lipophilicity parameters by multiple linear regression analysis. This approach gives us the possibility to gain insight into factors responsible for the retention as well as lipophilicity of the investigated set of the compounds. The most prominent factors affecting lipophilicity of the investigated substances are Solubility, Energy of the highest occupied molecular orbital, and Energy of the lowest unoccupied molecular orbital. The obtained models were used for interpretation of the lipophilicity of the investigated compounds. The prediction results are in good agreement with the experimental value. This study provides good information about pharmacologically important physico-chemical parameters of observed antipsychotics relevant to variations in molecular lipophilicity and chromatographic behavior. Established QSAR models could be helpful in design of novel multitarget antipsychotic compounds.
PB  - Scientific Research Publishing
T2  - American Journal of Analytical Chemistry
T1  - Quantitative Structure-Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions
VL  - 5
IS  - 5
SP  - 335
EP  - 342
DO  - 10.4236/ajac.2014.55041
ER  - 

@article{
author = "Perušković, Danica S. and Stevanović, Nikola R. and Lolić, Aleksandar and Nikolić, Milan and Baošić, Rada",
year = "2014",
abstract = "The retention behavior and lipophilicity parameters of some antiphychotics were determined using reversed-phase thin layer chromatography. Quantitative structure-activity relationships studies have been performed to correlate the molecular characteristics of observed compounds with their retention as well as with their chromatographically determinated lipophilicity parameters.
The effect of different organic modifiers (acetone, tetrahydrofuran, and methanol) has been studied. The retention of investigated compounds decreases linearly with increasing concentration of organic modifier. The chemical structures of the antipsychotics have been characterized by molecular descriptors which are calculated from the structure and related to chromatographically determinated lipophilicity parameters by multiple linear regression analysis. This approach gives us the possibility to gain insight into factors responsible for the retention as well as lipophilicity of the investigated set of the compounds. The most prominent factors affecting lipophilicity of the investigated substances are Solubility, Energy of the highest occupied molecular orbital, and Energy of the lowest unoccupied molecular orbital. The obtained models were used for interpretation of the lipophilicity of the investigated compounds. The prediction results are in good agreement with the experimental value. This study provides good information about pharmacologically important physico-chemical parameters of observed antipsychotics relevant to variations in molecular lipophilicity and chromatographic behavior. Established QSAR models could be helpful in design of novel multitarget antipsychotic compounds.",
publisher = "Scientific Research Publishing",
journal = "American Journal of Analytical Chemistry",
title = "Quantitative Structure-Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions",
volume = "5",
number = "5",
pages = "335-342",
doi = "10.4236/ajac.2014.55041"
}

Perušković, D. S., Stevanović, N. R., Lolić, A., Nikolić, M.,& Baošić, R.. (2014). Quantitative Structure-Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions. in American Journal of Analytical Chemistry
Scientific Research Publishing., 5(5), 335-342.
https://doi.org/10.4236/ajac.2014.55041

Perušković DS, Stevanović NR, Lolić A, Nikolić M, Baošić R. Quantitative Structure-Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions. in American Journal of Analytical Chemistry. 2014;5(5):335-342.
doi:10.4236/ajac.2014.55041 .

Perušković, Danica S., Stevanović, Nikola R., Lolić, Aleksandar, Nikolić, Milan, Baošić, Rada, "Quantitative Structure-Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions" in American Journal of Analytical Chemistry, 5, no. 5 (2014):335-342,
https://doi.org/10.4236/ajac.2014.55041 . .

TY  - CONF
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Lolić, Aleksandar
AU  - Mandić, Snežana
AU  - Baošić, Rada
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4993
AB  - Schiff bases play an important role in inorganic chemistry as they easily form stable complexes
with majority of transition metal ions. Complexes of Schiff bases have been recognized as
models for biologically important species. The aim of this work is to investigate chromatographic
behaviour of series of 12 tetradentate Schiff bases and corresponding copper(II) and
nickel(II) complexes by normal- and reversed-phase thin layer chromatography, and optimization
of chromatographic conditions for their separation. Chromatographic methods have been
frequently applied for determination of retention parameter (RM), which is used for quantitative
relationships between chemical structure and retention. The chemical structures of investigated
compounds can be characterized by molecular descriptors. Quantitative structure-retention relationship
(QSRR) describes how molecular structure affects chromatographic retention. In the case
of thin layer chromatography, the QSRR studies are usually based on RM value, which is defined
by Bate-Smith and Westall eguation. In this study we used two stationary and twenty two
mobile phases. Also, in this work we used multivariant regression analysis to confirm the optimal
chromatographic conditions.
C3  - 9th Aegean Analytical Chemistry Days, 29 Sept-03 Oct 2014, Chios, Greece, Book of Abstracts, P4-09
T1  - Chromatographic behaviour of tetradentate Schiff base and corresponding Copper(II) and Nickel(II) complexes by NP- and RP-TLC
SP  - 193
EP  - 193
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4993
ER  - 

@conference{
author = "Perušković, Danica S. and Stevanović, Nikola R. and Lolić, Aleksandar and Mandić, Snežana and Baošić, Rada",
year = "2014",
abstract = "Schiff bases play an important role in inorganic chemistry as they easily form stable complexes
with majority of transition metal ions. Complexes of Schiff bases have been recognized as
models for biologically important species. The aim of this work is to investigate chromatographic
behaviour of series of 12 tetradentate Schiff bases and corresponding copper(II) and
nickel(II) complexes by normal- and reversed-phase thin layer chromatography, and optimization
of chromatographic conditions for their separation. Chromatographic methods have been
frequently applied for determination of retention parameter (RM), which is used for quantitative
relationships between chemical structure and retention. The chemical structures of investigated
compounds can be characterized by molecular descriptors. Quantitative structure-retention relationship
(QSRR) describes how molecular structure affects chromatographic retention. In the case
of thin layer chromatography, the QSRR studies are usually based on RM value, which is defined
by Bate-Smith and Westall eguation. In this study we used two stationary and twenty two
mobile phases. Also, in this work we used multivariant regression analysis to confirm the optimal
chromatographic conditions.",
journal = "9th Aegean Analytical Chemistry Days, 29 Sept-03 Oct 2014, Chios, Greece, Book of Abstracts, P4-09",
title = "Chromatographic behaviour of tetradentate Schiff base and corresponding Copper(II) and Nickel(II) complexes by NP- and RP-TLC",
pages = "193-193",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4993"
}

Perušković, D. S., Stevanović, N. R., Lolić, A., Mandić, S.,& Baošić, R.. (2014). Chromatographic behaviour of tetradentate Schiff base and corresponding Copper(II) and Nickel(II) complexes by NP- and RP-TLC. in 9th Aegean Analytical Chemistry Days, 29 Sept-03 Oct 2014, Chios, Greece, Book of Abstracts, P4-09, 193-193.
https://hdl.handle.net/21.15107/rcub_cherry_4993

Perušković DS, Stevanović NR, Lolić A, Mandić S, Baošić R. Chromatographic behaviour of tetradentate Schiff base and corresponding Copper(II) and Nickel(II) complexes by NP- and RP-TLC. in 9th Aegean Analytical Chemistry Days, 29 Sept-03 Oct 2014, Chios, Greece, Book of Abstracts, P4-09. 2014;:193-193.
https://hdl.handle.net/21.15107/rcub_cherry_4993 .

Perušković, Danica S., Stevanović, Nikola R., Lolić, Aleksandar, Mandić, Snežana, Baošić, Rada, "Chromatographic behaviour of tetradentate Schiff base and corresponding Copper(II) and Nickel(II) complexes by NP- and RP-TLC" in 9th Aegean Analytical Chemistry Days, 29 Sept-03 Oct 2014, Chios, Greece, Book of Abstracts, P4-09 (2014):193-193,
https://hdl.handle.net/21.15107/rcub_cherry_4993 .

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Stevanović, Nikola R.
AU  - Lončar, Nikola L.
AU  - Baošić, Rada
AU  - Vujčić, Zoran
AU  - Božić, Nataša
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1771
AB  - Several natural isolates of Bacillus strains namely 5B, 12B, 16B, 18 and 24B were grown at two different temperatures in submerged fermentation for the production of raw-starch-digesting alpha-amylases. All strains except Bacillus sp. 18 produced more alpha-amylase at 37 degrees C. The hydrolysis of raw cornstarch followed the same pattern. Efficient hydrolysis was obtained with alpha-amylases from Bacillus sp. 5B, 12B, 16B and 24B grown at 37 degrees C and Bacillus sp. 18 grown at 50 degrees C. Zymography after isoelectric focusing showed that alpha-amylases were produced in multiple forms, from 2 to 6, depending on the strain when they were growing at 37 degrees C, while growth at 50 degrees C induced only 1 or 2 isoforms. Thin layer chromatography (TLC) analysis of the hydrolysis products of raw corn and soluble starch by alpha-amylases revealed the production of various mixtures of oligosaccharides. In most cases, G3 was the most dominant product from soluble starch while G2, G3 and G5 were the main products of raw starch hydrolysis. This indicates that the obtained alpha-amylases could be used for starch liquidification or short-chain-oligosaccharide formation, depending on the type of starch (raw or soluble) used for the hydrolysis.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - A thin layer chromatographic comparison of raw and soluble starch hydrolysis patterns of some alpha-amylases from Bacillus sp isolated in Serbia
VL  - 79
IS  - 4
SP  - 411
EP  - 420
DO  - 10.2298/JSC130909155G
ER  - 

@article{
author = "Gligorijević, Nikola and Stevanović, Nikola R. and Lončar, Nikola L. and Baošić, Rada and Vujčić, Zoran and Božić, Nataša",
year = "2014",
abstract = "Several natural isolates of Bacillus strains namely 5B, 12B, 16B, 18 and 24B were grown at two different temperatures in submerged fermentation for the production of raw-starch-digesting alpha-amylases. All strains except Bacillus sp. 18 produced more alpha-amylase at 37 degrees C. The hydrolysis of raw cornstarch followed the same pattern. Efficient hydrolysis was obtained with alpha-amylases from Bacillus sp. 5B, 12B, 16B and 24B grown at 37 degrees C and Bacillus sp. 18 grown at 50 degrees C. Zymography after isoelectric focusing showed that alpha-amylases were produced in multiple forms, from 2 to 6, depending on the strain when they were growing at 37 degrees C, while growth at 50 degrees C induced only 1 or 2 isoforms. Thin layer chromatography (TLC) analysis of the hydrolysis products of raw corn and soluble starch by alpha-amylases revealed the production of various mixtures of oligosaccharides. In most cases, G3 was the most dominant product from soluble starch while G2, G3 and G5 were the main products of raw starch hydrolysis. This indicates that the obtained alpha-amylases could be used for starch liquidification or short-chain-oligosaccharide formation, depending on the type of starch (raw or soluble) used for the hydrolysis.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "A thin layer chromatographic comparison of raw and soluble starch hydrolysis patterns of some alpha-amylases from Bacillus sp isolated in Serbia",
volume = "79",
number = "4",
pages = "411-420",
doi = "10.2298/JSC130909155G"
}

Gligorijević, N., Stevanović, N. R., Lončar, N. L., Baošić, R., Vujčić, Z.,& Božić, N.. (2014). A thin layer chromatographic comparison of raw and soluble starch hydrolysis patterns of some alpha-amylases from Bacillus sp isolated in Serbia. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(4), 411-420.
https://doi.org/10.2298/JSC130909155G

Gligorijević N, Stevanović NR, Lončar NL, Baošić R, Vujčić Z, Božić N. A thin layer chromatographic comparison of raw and soluble starch hydrolysis patterns of some alpha-amylases from Bacillus sp isolated in Serbia. in Journal of the Serbian Chemical Society. 2014;79(4):411-420.
doi:10.2298/JSC130909155G .

Gligorijević, Nikola, Stevanović, Nikola R., Lončar, Nikola L., Baošić, Rada, Vujčić, Zoran, Božić, Nataša, "A thin layer chromatographic comparison of raw and soluble starch hydrolysis patterns of some alpha-amylases from Bacillus sp isolated in Serbia" in Journal of the Serbian Chemical Society, 79, no. 4 (2014):411-420,
https://doi.org/10.2298/JSC130909155G . .