TY  - JOUR
AU  - Zec, Manja
AU  - Srdić-Rajić, Tatjana
AU  - Krivokuca, Ana
AU  - Jankovic, Radmila
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Radulović, Siniša
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1877
AB  - The synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes of Zn(II), Cd(II) and Ni(II) were published previously. Here we report first evidence on anti-proliferative activity of the complexes and molecular patterns that underlie it. The complexes and the corresponding ligand are shown to be cytotoxic on the panel of nine, malignant and non-malignant cell lines, with the exception of Ni(II) complex that did not achieve IC50 value on any of the cell lines tested. Further experiments on the selected cell lines including A 549, MRC-5, EA.hy 926 and HeLa, have shown that the complexes posses unambiguous property of inducing necrosis in the cells treated for 6 hours, with the ligand and Zn(II) complex being the most active on all cell lines. On the contrary, only small portion of early apoptotic events was detected, under the same experimental condition. This was in complete concordance with the results obtained from Western blot analysis of the treated cells that showed no or slight increase of the protein amounts of two crucial apoptotic mediators: Cytochrome C and Caspase III. We propose the model, under which tested complexes induce necroptosis in treated cells, a recently described type of cell death with necrotic morphological features and acting via caspase independent pathway, and without elevated amounts of intracellular ROS. Endothelial EA.hy 926 cells have proven to be extremely sensitive on the necrosis-inducing effect of the complexes, which could indicate potential anti-angiogenic effect of the novel complexes that is to be investigated.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Medicinal Chemistry
T1  - Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death
VL  - 10
IS  - 8
SP  - 759
EP  - 771
DO  - 10.2174/1573406410666140327122009
ER  - 

@article{
author = "Zec, Manja and Srdić-Rajić, Tatjana and Krivokuca, Ana and Jankovic, Radmila and Todorović, Tamara and Anđelković, Katarina K. and Radulović, Siniša",
year = "2014",
abstract = "The synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes of Zn(II), Cd(II) and Ni(II) were published previously. Here we report first evidence on anti-proliferative activity of the complexes and molecular patterns that underlie it. The complexes and the corresponding ligand are shown to be cytotoxic on the panel of nine, malignant and non-malignant cell lines, with the exception of Ni(II) complex that did not achieve IC50 value on any of the cell lines tested. Further experiments on the selected cell lines including A 549, MRC-5, EA.hy 926 and HeLa, have shown that the complexes posses unambiguous property of inducing necrosis in the cells treated for 6 hours, with the ligand and Zn(II) complex being the most active on all cell lines. On the contrary, only small portion of early apoptotic events was detected, under the same experimental condition. This was in complete concordance with the results obtained from Western blot analysis of the treated cells that showed no or slight increase of the protein amounts of two crucial apoptotic mediators: Cytochrome C and Caspase III. We propose the model, under which tested complexes induce necroptosis in treated cells, a recently described type of cell death with necrotic morphological features and acting via caspase independent pathway, and without elevated amounts of intracellular ROS. Endothelial EA.hy 926 cells have proven to be extremely sensitive on the necrosis-inducing effect of the complexes, which could indicate potential anti-angiogenic effect of the novel complexes that is to be investigated.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Medicinal Chemistry",
title = "Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death",
volume = "10",
number = "8",
pages = "759-771",
doi = "10.2174/1573406410666140327122009"
}

Zec, M., Srdić-Rajić, T., Krivokuca, A., Jankovic, R., Todorović, T., Anđelković, K. K.,& Radulović, S.. (2014). Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death. in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 10(8), 759-771.
https://doi.org/10.2174/1573406410666140327122009

Zec M, Srdić-Rajić T, Krivokuca A, Jankovic R, Todorović T, Anđelković KK, Radulović S. Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death. in Medicinal Chemistry. 2014;10(8):759-771.
doi:10.2174/1573406410666140327122009 .

Zec, Manja, Srdić-Rajić, Tatjana, Krivokuca, Ana, Jankovic, Radmila, Todorović, Tamara, Anđelković, Katarina K., Radulović, Siniša, "Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death" in Medicinal Chemistry, 10, no. 8 (2014):759-771,
https://doi.org/10.2174/1573406410666140327122009 . .

TY  - JOUR
AU  - Zec, Manja
AU  - Srdić-Rajić, Tatjana
AU  - Konic-Ristic, Aleksandra
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Filipovic-Ljeskovic, Ivana
AU  - Radulović, Siniša
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1539
AB  - Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
VL  - 12
IS  - 9
SP  - 1071
EP  - 1080
DO  - 10.2174/187152012803529682
ER  - 

@article{
author = "Zec, Manja and Srdić-Rajić, Tatjana and Konic-Ristic, Aleksandra and Todorović, Tamara and Anđelković, Katarina K. and Filipovic-Ljeskovic, Ivana and Radulović, Siniša",
year = "2012",
abstract = "Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones",
volume = "12",
number = "9",
pages = "1071-1080",
doi = "10.2174/187152012803529682"
}

Zec, M., Srdić-Rajić, T., Konic-Ristic, A., Todorović, T., Anđelković, K. K., Filipovic-Ljeskovic, I.,& Radulović, S.. (2012). Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 12(9), 1071-1080.
https://doi.org/10.2174/187152012803529682

Zec M, Srdić-Rajić T, Konic-Ristic A, Todorović T, Anđelković KK, Filipovic-Ljeskovic I, Radulović S. Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry. 2012;12(9):1071-1080.
doi:10.2174/187152012803529682 .

Zec, Manja, Srdić-Rajić, Tatjana, Konic-Ristic, Aleksandra, Todorović, Tamara, Anđelković, Katarina K., Filipovic-Ljeskovic, Ivana, Radulović, Siniša, "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones" in Anti-Cancer Agents in Medicinal Chemistry, 12, no. 9 (2012):1071-1080,
https://doi.org/10.2174/187152012803529682 . .

TY  - JOUR
AU  - Eshkourfu, Rabia
AU  - Čobeljić, Božidar
AU  - Vujčić, Miroslava
AU  - Turel, Iztok
AU  - Pevec, Andrej
AU  - Sepcic, Kristina
AU  - Zec, Manja
AU  - Radulović, Siniša
AU  - Srdić-Rajić, Tatjana
AU  - Mitić, Dragana
AU  - Anđelković, Katarina K.
AU  - Sladić, Dušan
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1191
AB  - A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding. (C) 2011 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
VL  - 105
IS  - 9
SP  - 1196
EP  - 1203
DO  - 10.1016/j.jinorgbio.2011.05.024
ER  - 

@article{
author = "Eshkourfu, Rabia and Čobeljić, Božidar and Vujčić, Miroslava and Turel, Iztok and Pevec, Andrej and Sepcic, Kristina and Zec, Manja and Radulović, Siniša and Srdić-Rajić, Tatjana and Mitić, Dragana and Anđelković, Katarina K. and Sladić, Dušan",
year = "2011",
abstract = "A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding. (C) 2011 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide",
volume = "105",
number = "9",
pages = "1196-1203",
doi = "10.1016/j.jinorgbio.2011.05.024"
}

Eshkourfu, R., Čobeljić, B., Vujčić, M., Turel, I., Pevec, A., Sepcic, K., Zec, M., Radulović, S., Srdić-Rajić, T., Mitić, D., Anđelković, K. K.,& Sladić, D.. (2011). Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 105(9), 1196-1203.
https://doi.org/10.1016/j.jinorgbio.2011.05.024

Eshkourfu R, Čobeljić B, Vujčić M, Turel I, Pevec A, Sepcic K, Zec M, Radulović S, Srdić-Rajić T, Mitić D, Anđelković KK, Sladić D. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry. 2011;105(9):1196-1203.
doi:10.1016/j.jinorgbio.2011.05.024 .

Eshkourfu, Rabia, Čobeljić, Božidar, Vujčić, Miroslava, Turel, Iztok, Pevec, Andrej, Sepcic, Kristina, Zec, Manja, Radulović, Siniša, Srdić-Rajić, Tatjana, Mitić, Dragana, Anđelković, Katarina K., Sladić, Dušan, "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide" in Journal of Inorganic Biochemistry, 105, no. 9 (2011):1196-1203,
https://doi.org/10.1016/j.jinorgbio.2011.05.024 . .

TY  - JOUR
AU  - Srdić-Rajić, Tatjana
AU  - Zec, Manja
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Radulović, Siniša
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1200
AB  - We previously published the synthesis, characterization and cytotoxic effect of the novel Zn(II), Ni(II), and Cd(II) complexes with 2-formylpyridine selenosemicarbazone. Here we further investigate the mechanism of their antiproliferative activity against several cancer and vascular endothelial cell lines and compared it to the activity of the ligand itself, corresponding salts and, as a referent compound, cisplatin. Investigated complexes induced apoptosis in a time- and dose-dependent manner as well as changes in a cell cycle distribution. Caspase-3 activation in HeLa cells, MDA-MB-361 and vascular endothelial cells EA.hy 926 cells by ligand alone, as well as Zn(II), Ni(II), and Cd(II) complexes was preceded by the activation of the p53 tumor-suppressor gene family protein p73. In addition to activation of p73, these compounds also trigger cytochrome C release by upregulation of Bax expression. The release of cytochrome C has been linked to loss of mitochondrial membrane potential. However, our data indicated that the increased phosphorylation of ERK could be also one of the mechanism involved in the Zn(II), and Cd(II) complexes- induction of apoptosis. Selenosemicarbazone complexes with Cd(II) and Ni(II), possess dual ability to induce apoptosis as well as necrosis, and might present an added advantage for inducing cell death in a diverse array of malignant cells. Taken together, our findings could indicate potential role of these complexes as activator of cross-talk between different signaling pathways that leads to cell death, and thus making the complex intriguing field for further scientific, and maybe clinical investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway
VL  - 46
IS  - 9
SP  - 3734
EP  - 3747
DO  - 10.1016/j.ejmech.2011.05.039
ER  - 

@article{
author = "Srdić-Rajić, Tatjana and Zec, Manja and Todorović, Tamara and Anđelković, Katarina K. and Radulović, Siniša",
year = "2011",
abstract = "We previously published the synthesis, characterization and cytotoxic effect of the novel Zn(II), Ni(II), and Cd(II) complexes with 2-formylpyridine selenosemicarbazone. Here we further investigate the mechanism of their antiproliferative activity against several cancer and vascular endothelial cell lines and compared it to the activity of the ligand itself, corresponding salts and, as a referent compound, cisplatin. Investigated complexes induced apoptosis in a time- and dose-dependent manner as well as changes in a cell cycle distribution. Caspase-3 activation in HeLa cells, MDA-MB-361 and vascular endothelial cells EA.hy 926 cells by ligand alone, as well as Zn(II), Ni(II), and Cd(II) complexes was preceded by the activation of the p53 tumor-suppressor gene family protein p73. In addition to activation of p73, these compounds also trigger cytochrome C release by upregulation of Bax expression. The release of cytochrome C has been linked to loss of mitochondrial membrane potential. However, our data indicated that the increased phosphorylation of ERK could be also one of the mechanism involved in the Zn(II), and Cd(II) complexes- induction of apoptosis. Selenosemicarbazone complexes with Cd(II) and Ni(II), possess dual ability to induce apoptosis as well as necrosis, and might present an added advantage for inducing cell death in a diverse array of malignant cells. Taken together, our findings could indicate potential role of these complexes as activator of cross-talk between different signaling pathways that leads to cell death, and thus making the complex intriguing field for further scientific, and maybe clinical investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway",
volume = "46",
number = "9",
pages = "3734-3747",
doi = "10.1016/j.ejmech.2011.05.039"
}

Srdić-Rajić, T., Zec, M., Todorović, T., Anđelković, K. K.,& Radulović, S.. (2011). Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 46(9), 3734-3747.
https://doi.org/10.1016/j.ejmech.2011.05.039

Srdić-Rajić T, Zec M, Todorović T, Anđelković KK, Radulović S. Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway. in European Journal of Medicinal Chemistry. 2011;46(9):3734-3747.
doi:10.1016/j.ejmech.2011.05.039 .

Srdić-Rajić, Tatjana, Zec, Manja, Todorović, Tamara, Anđelković, Katarina K., Radulović, Siniša, "Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway" in European Journal of Medicinal Chemistry, 46, no. 9 (2011):3734-3747,
https://doi.org/10.1016/j.ejmech.2011.05.039 . .

TY  - JOUR
AU  - Bjelogrlić, Snežana K.
AU  - Todorović, Tamara
AU  - Bacchi, Alessia
AU  - Zec, Manja
AU  - Sladić, Dušan
AU  - Srdić-Rajić, Tatjana
AU  - Radanović, Dušanka D.
AU  - Radulović, Siniša
AU  - Pelizzi, Giancarlo
AU  - Anđelković, Katarina K.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1081
AB  - Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes
VL  - 104
IS  - 6
SP  - 673
EP  - 682
DO  - 10.1016/j.jinorgbio.2010.02.009
ER  - 

@article{
author = "Bjelogrlić, Snežana K. and Todorović, Tamara and Bacchi, Alessia and Zec, Manja and Sladić, Dušan and Srdić-Rajić, Tatjana and Radanović, Dušanka D. and Radulović, Siniša and Pelizzi, Giancarlo and Anđelković, Katarina K.",
year = "2010",
abstract = "Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes",
volume = "104",
number = "6",
pages = "673-682",
doi = "10.1016/j.jinorgbio.2010.02.009"
}

Bjelogrlić, S. K., Todorović, T., Bacchi, A., Zec, M., Sladić, D., Srdić-Rajić, T., Radanović, D. D., Radulović, S., Pelizzi, G.,& Anđelković, K. K.. (2010). Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 104(6), 673-682.
https://doi.org/10.1016/j.jinorgbio.2010.02.009

Bjelogrlić SK, Todorović T, Bacchi A, Zec M, Sladić D, Srdić-Rajić T, Radanović DD, Radulović S, Pelizzi G, Anđelković KK. Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry. 2010;104(6):673-682.
doi:10.1016/j.jinorgbio.2010.02.009 .

Bjelogrlić, Snežana K., Todorović, Tamara, Bacchi, Alessia, Zec, Manja, Sladić, Dušan, Srdić-Rajić, Tatjana, Radanović, Dušanka D., Radulović, Siniša, Pelizzi, Giancarlo, Anđelković, Katarina K., "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes" in Journal of Inorganic Biochemistry, 104, no. 6 (2010):673-682,
https://doi.org/10.1016/j.jinorgbio.2010.02.009 . .