TY  - JOUR
AU  - Simic, Vera
AU  - Kolarević, Stoimir
AU  - Brčeski, Ilija
AU  - Jeremić, Dejan
AU  - Vuković-Gačić, Branka
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2269
AB  - Metal coordination compounds have an important role in the development of novel drugs. Using the resazurin microtitration assay we assessed the cytotoxicity and antiviral activity of the ligand 2-(diphenylphosphino) benzaldehyde 1-adamantoylhydrazone and its Pd(II) and Pt(II) complexes. Cytotoxicity was tested in A549 human lung adenocarcinoma epithelial cells. We observed that the ligand displayed a more pronounced cytotoxic activity than the platinum-based drug, carboplatin. Morphological evaluation of A549 cells treated with the ligand by acridine orange and ethidium bromide double staining revealed the presence of signs of apoptosis. Antiviral activity against poliovirus type 1 was assessed by examination of the cytopathic effect (CPE) in Hep-2 cells. Cells that were exposed to the 19 mu M ligand before infection displayed a maximal significant reduction (by 24.42 +/- 1.49%) of the CPE. This was likely due to the inhibition of virus receptors and prevention of viral adsorption. Treatment with 17 mu M Pt(II) complex after viral infection caused a maximal significant reduction (by 30.52 +/- 3.12%) of the CPE, presumably through an effect on viral replication. The results indicate that the ligand should be viewed as a potential anticancer agent. The ligand and the Pt(II) complex show promising results for further investigation of antiviral activity.
PB  - Tubitak Scientific & Technical Research Council Turkey, Ankara
T2  - Turkish Journal of Biology
T1  - Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone
VL  - 40
IS  - 3
SP  - 661
EP  - 669
DO  - 10.3906/biy-1503-23
ER  - 

@article{
author = "Simic, Vera and Kolarević, Stoimir and Brčeski, Ilija and Jeremić, Dejan and Vuković-Gačić, Branka",
year = "2016",
abstract = "Metal coordination compounds have an important role in the development of novel drugs. Using the resazurin microtitration assay we assessed the cytotoxicity and antiviral activity of the ligand 2-(diphenylphosphino) benzaldehyde 1-adamantoylhydrazone and its Pd(II) and Pt(II) complexes. Cytotoxicity was tested in A549 human lung adenocarcinoma epithelial cells. We observed that the ligand displayed a more pronounced cytotoxic activity than the platinum-based drug, carboplatin. Morphological evaluation of A549 cells treated with the ligand by acridine orange and ethidium bromide double staining revealed the presence of signs of apoptosis. Antiviral activity against poliovirus type 1 was assessed by examination of the cytopathic effect (CPE) in Hep-2 cells. Cells that were exposed to the 19 mu M ligand before infection displayed a maximal significant reduction (by 24.42 +/- 1.49%) of the CPE. This was likely due to the inhibition of virus receptors and prevention of viral adsorption. Treatment with 17 mu M Pt(II) complex after viral infection caused a maximal significant reduction (by 30.52 +/- 3.12%) of the CPE, presumably through an effect on viral replication. The results indicate that the ligand should be viewed as a potential anticancer agent. The ligand and the Pt(II) complex show promising results for further investigation of antiviral activity.",
publisher = "Tubitak Scientific & Technical Research Council Turkey, Ankara",
journal = "Turkish Journal of Biology",
title = "Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone",
volume = "40",
number = "3",
pages = "661-669",
doi = "10.3906/biy-1503-23"
}

Simic, V., Kolarević, S., Brčeski, I., Jeremić, D.,& Vuković-Gačić, B.. (2016). Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone. in Turkish Journal of Biology
Tubitak Scientific & Technical Research Council Turkey, Ankara., 40(3), 661-669.
https://doi.org/10.3906/biy-1503-23

Simic V, Kolarević S, Brčeski I, Jeremić D, Vuković-Gačić B. Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone. in Turkish Journal of Biology. 2016;40(3):661-669.
doi:10.3906/biy-1503-23 .

Simic, Vera, Kolarević, Stoimir, Brčeski, Ilija, Jeremić, Dejan, Vuković-Gačić, Branka, "Cytotoxicity and antiviral activity of palladium(II) and platinum(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone" in Turkish Journal of Biology, 40, no. 3 (2016):661-669,
https://doi.org/10.3906/biy-1503-23 . .

TY  - JOUR
AU  - Đorđević, Milena M.
AU  - Jeremić, Dejan
AU  - Rodić, Marko
AU  - Simic, Vera S.
AU  - Brčeski, Ilija
AU  - Leovac, Vukadin M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1504
AB  - The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone
VL  - 68
SP  - 234
EP  - 240
DO  - 10.1016/j.poly.2013.10.029
ER  - 

@article{
author = "Đorđević, Milena M. and Jeremić, Dejan and Rodić, Marko and Simic, Vera S. and Brčeski, Ilija and Leovac, Vukadin M.",
year = "2014",
abstract = "The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone",
volume = "68",
pages = "234-240",
doi = "10.1016/j.poly.2013.10.029"
}

Đorđević, M. M., Jeremić, D., Rodić, M., Simic, V. S., Brčeski, I.,& Leovac, V. M.. (2014). Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 68, 234-240.
https://doi.org/10.1016/j.poly.2013.10.029

Đorđević MM, Jeremić D, Rodić M, Simic VS, Brčeski I, Leovac VM. Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone. in Polyhedron. 2014;68:234-240.
doi:10.1016/j.poly.2013.10.029 .

Đorđević, Milena M., Jeremić, Dejan, Rodić, Marko, Simic, Vera S., Brčeski, Ilija, Leovac, Vukadin M., "Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone" in Polyhedron, 68 (2014):234-240,
https://doi.org/10.1016/j.poly.2013.10.029 . .