TY  - JOUR
AU  - Hollo, Berta
AU  - Rodić, Marko
AU  - Vojinović-Ješić, Ljiljana S.
AU  - Živković-Radovanović, Vukosava
AU  - Vuckovic, Gordana
AU  - Leovac, Vukadin M.
AU  - Szecsenyi, Katalin Meszaros
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1767
AB  - The synthesis of a potentially bioactive mixed-valence Co-III/Co-II complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed [(CoL2)-L-III][(CoCl3)-Cl-II py]center dot Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It's thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas [CoL2]NO3 center dot MeOH (1), [CoL2]Br center dot MeOH (2), [CoL2]HSO4 center dot MeOH (3), [CoL2](2)[Co-II(NCS)(4)] (4), [Co(HL)(L)]I-2 center dot 2MeOH (5), and [Co(HL)(L)][(CoCl4)-Cl-II]center dot MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gram-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes.
PB  - Springer, Dordrecht
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes
VL  - 116
IS  - 2
SP  - 655
EP  - 662
DO  - 10.1007/s10973-013-3489-1
ER  - 

@article{
author = "Hollo, Berta and Rodić, Marko and Vojinović-Ješić, Ljiljana S. and Živković-Radovanović, Vukosava and Vuckovic, Gordana and Leovac, Vukadin M. and Szecsenyi, Katalin Meszaros",
year = "2014",
abstract = "The synthesis of a potentially bioactive mixed-valence Co-III/Co-II complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed [(CoL2)-L-III][(CoCl3)-Cl-II py]center dot Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It's thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas [CoL2]NO3 center dot MeOH (1), [CoL2]Br center dot MeOH (2), [CoL2]HSO4 center dot MeOH (3), [CoL2](2)[Co-II(NCS)(4)] (4), [Co(HL)(L)]I-2 center dot 2MeOH (5), and [Co(HL)(L)][(CoCl4)-Cl-II]center dot MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gram-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes.",
publisher = "Springer, Dordrecht",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes",
volume = "116",
number = "2",
pages = "655-662",
doi = "10.1007/s10973-013-3489-1"
}

Hollo, B., Rodić, M., Vojinović-Ješić, L. S., Živković-Radovanović, V., Vuckovic, G., Leovac, V. M.,& Szecsenyi, K. M.. (2014). Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes. in Journal of Thermal Analysis and Calorimetry
Springer, Dordrecht., 116(2), 655-662.
https://doi.org/10.1007/s10973-013-3489-1

Hollo B, Rodić M, Vojinović-Ješić LS, Živković-Radovanović V, Vuckovic G, Leovac VM, Szecsenyi KM. Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes. in Journal of Thermal Analysis and Calorimetry. 2014;116(2):655-662.
doi:10.1007/s10973-013-3489-1 .

Hollo, Berta, Rodić, Marko, Vojinović-Ješić, Ljiljana S., Živković-Radovanović, Vukosava, Vuckovic, Gordana, Leovac, Vukadin M., Szecsenyi, Katalin Meszaros, "Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes" in Journal of Thermal Analysis and Calorimetry, 116, no. 2 (2014):655-662,
https://doi.org/10.1007/s10973-013-3489-1 . .

TY  - JOUR
AU  - Joksović, Milan D.
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna
AU  - Szecsenyi, Katalin Meszaros
AU  - Leovac, Vukadin M.
AU  - Jakimov, Dimitar
AU  - Trifunović, Snežana S.
AU  - Marković, Violeta
AU  - Joksović, Ljubinka
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1097
AB  - New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Heterocyclic Chemistry
T1  - Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids
VL  - 47
IS  - 4
SP  - 850
EP  - 856
DO  - 10.1002/jhet.400
ER  - 

@article{
author = "Joksović, Milan D. and Bogdanović, Gordana and Kojić, Vesna and Szecsenyi, Katalin Meszaros and Leovac, Vukadin M. and Jakimov, Dimitar and Trifunović, Snežana S. and Marković, Violeta and Joksović, Ljubinka",
year = "2010",
abstract = "New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Heterocyclic Chemistry",
title = "Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids",
volume = "47",
number = "4",
pages = "850-856",
doi = "10.1002/jhet.400"
}

Joksović, M. D., Bogdanović, G., Kojić, V., Szecsenyi, K. M., Leovac, V. M., Jakimov, D., Trifunović, S. S., Marković, V.,& Joksović, L.. (2010). Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids. in Journal of Heterocyclic Chemistry
Wiley-Blackwell, Malden., 47(4), 850-856.
https://doi.org/10.1002/jhet.400

Joksović MD, Bogdanović G, Kojić V, Szecsenyi KM, Leovac VM, Jakimov D, Trifunović SS, Marković V, Joksović L. Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids. in Journal of Heterocyclic Chemistry. 2010;47(4):850-856.
doi:10.1002/jhet.400 .

Joksović, Milan D., Bogdanović, Gordana, Kojić, Vesna, Szecsenyi, Katalin Meszaros, Leovac, Vukadin M., Jakimov, Dimitar, Trifunović, Snežana S., Marković, Violeta, Joksović, Ljubinka, "Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids" in Journal of Heterocyclic Chemistry, 47, no. 4 (2010):850-856,
https://doi.org/10.1002/jhet.400 . .

TY  - JOUR
AU  - Joksović, Milan D.
AU  - Marković, Violeta
AU  - Juranić, Zorica D.
AU  - Stanojković, Tatjana
AU  - Jovanović, Ljiljana S.
AU  - Damljanovic, Ivan S.
AU  - Szecsenyi, Katalin Meszaros
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Vukicevic, Rastko D.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1024
AB  - A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] alpha-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 11 exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. (C) 2009 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety
VL  - 694
IS  - 24
SP  - 3935
EP  - 3942
DO  - 10.1016/j.jorganchem.2009.08.013
ER  - 

@article{
author = "Joksović, Milan D. and Marković, Violeta and Juranić, Zorica D. and Stanojković, Tatjana and Jovanović, Ljiljana S. and Damljanovic, Ivan S. and Szecsenyi, Katalin Meszaros and Todorović, Nina and Trifunović, Snežana S. and Vukicevic, Rastko D.",
year = "2009",
abstract = "A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] alpha-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 11 exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. (C) 2009 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety",
volume = "694",
number = "24",
pages = "3935-3942",
doi = "10.1016/j.jorganchem.2009.08.013"
}

Joksović, M. D., Marković, V., Juranić, Z. D., Stanojković, T., Jovanović, L. S., Damljanovic, I. S., Szecsenyi, K. M., Todorović, N., Trifunović, S. S.,& Vukicevic, R. D.. (2009). Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry
Elsevier Science Sa, Lausanne., 694(24), 3935-3942.
https://doi.org/10.1016/j.jorganchem.2009.08.013

Joksović MD, Marković V, Juranić ZD, Stanojković T, Jovanović LS, Damljanovic IS, Szecsenyi KM, Todorović N, Trifunović SS, Vukicevic RD. Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry. 2009;694(24):3935-3942.
doi:10.1016/j.jorganchem.2009.08.013 .

Joksović, Milan D., Marković, Violeta, Juranić, Zorica D., Stanojković, Tatjana, Jovanović, Ljiljana S., Damljanovic, Ivan S., Szecsenyi, Katalin Meszaros, Todorović, Nina, Trifunović, Snežana S., Vukicevic, Rastko D., "Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety" in Journal of Organometallic Chemistry, 694, no. 24 (2009):3935-3942,
https://doi.org/10.1016/j.jorganchem.2009.08.013 . .

TY  - JOUR
AU  - Leka, ZB
AU  - Leovac, Vukadin M.
AU  - Lukic, S
AU  - Sabo, Tibor
AU  - Trifunović, Srećko R.
AU  - Szecsenyi, KM
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/773
AB  - Triammonium-N-dithiocarboxyiminodiacetate, (NH4)(3)L, a new dithiocarbamato derivative of iminodiacetate, has been synthesized. The coordination properties of the ligand were tested in reactions with copper(II), nickel(II) and palladium(II) salts in acidic solutions. Complexes with a general formula M(H2L)(2) were obtained, with the coordination taking place through the sulfur atoms of the dithiocarbamate moiety. The new compounds were characterized by elemental analysis, UV/VIS and IR spectroscopy, thermal analysis and magnetic measurements. In addition, the ligand was characterized by H-1- and C-13-NMR spectroscopy and molar conductivity measurements. The copper(II) complex is paramagnetic, while the nickel(II) and palladium(II) compounds are diamagnetic. The thermal decomposition of all compounds is continuous and the thermal stability of the complexes is higher than that of the ligand, as expected.
PB  - Springer, Dordrecht
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Synthesis and physico-chemical characterization of new dithiocarabamato ligand and its complexes with copper(II), nickel(II) and palladium(II)
VL  - 83
IS  - 3
SP  - 687
EP  - 691
DO  - 10.1007/s10973-005-6938-7
ER  - 

@article{
author = "Leka, ZB and Leovac, Vukadin M. and Lukic, S and Sabo, Tibor and Trifunović, Srećko R. and Szecsenyi, KM",
year = "2006",
abstract = "Triammonium-N-dithiocarboxyiminodiacetate, (NH4)(3)L, a new dithiocarbamato derivative of iminodiacetate, has been synthesized. The coordination properties of the ligand were tested in reactions with copper(II), nickel(II) and palladium(II) salts in acidic solutions. Complexes with a general formula M(H2L)(2) were obtained, with the coordination taking place through the sulfur atoms of the dithiocarbamate moiety. The new compounds were characterized by elemental analysis, UV/VIS and IR spectroscopy, thermal analysis and magnetic measurements. In addition, the ligand was characterized by H-1- and C-13-NMR spectroscopy and molar conductivity measurements. The copper(II) complex is paramagnetic, while the nickel(II) and palladium(II) compounds are diamagnetic. The thermal decomposition of all compounds is continuous and the thermal stability of the complexes is higher than that of the ligand, as expected.",
publisher = "Springer, Dordrecht",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Synthesis and physico-chemical characterization of new dithiocarabamato ligand and its complexes with copper(II), nickel(II) and palladium(II)",
volume = "83",
number = "3",
pages = "687-691",
doi = "10.1007/s10973-005-6938-7"
}

Leka, Z., Leovac, V. M., Lukic, S., Sabo, T., Trifunović, S. R.,& Szecsenyi, K.. (2006). Synthesis and physico-chemical characterization of new dithiocarabamato ligand and its complexes with copper(II), nickel(II) and palladium(II). in Journal of Thermal Analysis and Calorimetry
Springer, Dordrecht., 83(3), 687-691.
https://doi.org/10.1007/s10973-005-6938-7

Leka Z, Leovac VM, Lukic S, Sabo T, Trifunović SR, Szecsenyi K. Synthesis and physico-chemical characterization of new dithiocarabamato ligand and its complexes with copper(II), nickel(II) and palladium(II). in Journal of Thermal Analysis and Calorimetry. 2006;83(3):687-691.
doi:10.1007/s10973-005-6938-7 .

Leka, ZB, Leovac, Vukadin M., Lukic, S, Sabo, Tibor, Trifunović, Srećko R., Szecsenyi, KM, "Synthesis and physico-chemical characterization of new dithiocarabamato ligand and its complexes with copper(II), nickel(II) and palladium(II)" in Journal of Thermal Analysis and Calorimetry, 83, no. 3 (2006):687-691,
https://doi.org/10.1007/s10973-005-6938-7 . .