TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Lakićević, Novak
AU  - Pavlović, Slađan Z.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6455
AB  - Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and harmful effects on the central nervous system. In this study, we present a comprehensive review and meta-analysis of peer-reviewed research encompassing five crucial clinical matrices: hair, whole blood, plasma, red blood cells (RBCs), and urine. We assess the disparities in Hg levels between gender- and age-matched neurotypical children (controls) and children diagnosed with autism spectrum disorder (ASD) (cases). After applying rigorous selection criteria, we incorporated a total of 60 case-control studies into our meta-analysis. These studies comprised 25 investigations of Hg levels in hair (controls/cases: 1134/1361), 15 in whole blood (controls/cases: 1019/1345), 6 in plasma (controls/cases: 224/263), 5 in RBCs (controls/cases: 215/293), and 9 in urine (controls/cases: 399/623). This meta-analysis did not include the data of ASD children who received chelation therapy. Our meta-analysis revealed no statistically significant differences in Hg levels in hair and urine between ASD cases and controls. In whole blood, plasma, and RBCs, Hg levels were significantly higher in ASD cases compared to their neurotypical counterparts. This indicates that ASD children could exhibit reduced detoxification capacity for Hg and impaired mechanisms for Hg excretion from their bodies. This underscores the detrimental role of Hg in ASD and underscores the critical importance of monitoring Hg levels in ASD children, particularly in early childhood. These findings emphasize the pressing need for global initiatives aimed at minimizing Hg exposure, thus highlighting the critical intersection of human–environment interaction and neurodevelopment health.
T2  - Biomedicines
T1  - Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis
VL  - 11
IS  - 12
SP  - 3344
DO  - 10.3390/biomedicines11123344
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Lakićević, Novak and Pavlović, Slađan Z.",
year = "2023",
abstract = "Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and harmful effects on the central nervous system. In this study, we present a comprehensive review and meta-analysis of peer-reviewed research encompassing five crucial clinical matrices: hair, whole blood, plasma, red blood cells (RBCs), and urine. We assess the disparities in Hg levels between gender- and age-matched neurotypical children (controls) and children diagnosed with autism spectrum disorder (ASD) (cases). After applying rigorous selection criteria, we incorporated a total of 60 case-control studies into our meta-analysis. These studies comprised 25 investigations of Hg levels in hair (controls/cases: 1134/1361), 15 in whole blood (controls/cases: 1019/1345), 6 in plasma (controls/cases: 224/263), 5 in RBCs (controls/cases: 215/293), and 9 in urine (controls/cases: 399/623). This meta-analysis did not include the data of ASD children who received chelation therapy. Our meta-analysis revealed no statistically significant differences in Hg levels in hair and urine between ASD cases and controls. In whole blood, plasma, and RBCs, Hg levels were significantly higher in ASD cases compared to their neurotypical counterparts. This indicates that ASD children could exhibit reduced detoxification capacity for Hg and impaired mechanisms for Hg excretion from their bodies. This underscores the detrimental role of Hg in ASD and underscores the critical importance of monitoring Hg levels in ASD children, particularly in early childhood. These findings emphasize the pressing need for global initiatives aimed at minimizing Hg exposure, thus highlighting the critical intersection of human–environment interaction and neurodevelopment health.",
journal = "Biomedicines",
title = "Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis",
volume = "11",
number = "12",
pages = "3344",
doi = "10.3390/biomedicines11123344"
}

Stojsavljević, A., Lakićević, N.,& Pavlović, S. Z.. (2023). Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis. in Biomedicines, 11(12), 3344.
https://doi.org/10.3390/biomedicines11123344

Stojsavljević A, Lakićević N, Pavlović SZ. Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis. in Biomedicines. 2023;11(12):3344.
doi:10.3390/biomedicines11123344 .

Stojsavljević, Aleksandar, Lakićević, Novak, Pavlović, Slađan Z., "Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis" in Biomedicines, 11, no. 12 (2023):3344,
https://doi.org/10.3390/biomedicines11123344 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Lakićević, Novak
AU  - Pavlović, Slađan Z.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6365
AB  - Environmental pollutants, particularly toxic trace metals with neurotoxic potential, have been related to the genesis of autism. One of these metals that stands out, in particular, is lead (Pb). We conducted an in-depth systematic review and meta-analysis of peer-reviewed studies on Pb levels in biological materials retrieved from autistic children (cases) and neurotypical children (controls) in this work. A systematic review was conducted after the careful selection of published studies according to established criteria to gain a broad insight into the higher or lower levels of Pb in the biological materials of cases and controls, and the findings were then strengthened by a meta-analysis. The meta-analysis included 17 studies (hair), 13 studies (whole blood), and 8 studies (urine). The overall number of controls/cases was 869/915 (hair), 670/755 (whole blood), and 344/373 (urine). This meta-analysis showed significantly higher Pb levels in all three types of biological material in cases than in controls, suggesting a higher body Pb burden in autistic children. Thus, environmental Pb exposure could be related to the genesis of autism. Since no level of Pb can be considered safe, the data from this study undoubtedly point to the importance of regularly monitoring Pb levels in autistic children.
PB  - MDPI
T2  - Toxics
T1  - Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis
VL  - 11
IS  - 9
SP  - 753
DO  - 10.3390/toxics11090753
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Lakićević, Novak and Pavlović, Slađan Z.",
year = "2023",
abstract = "Environmental pollutants, particularly toxic trace metals with neurotoxic potential, have been related to the genesis of autism. One of these metals that stands out, in particular, is lead (Pb). We conducted an in-depth systematic review and meta-analysis of peer-reviewed studies on Pb levels in biological materials retrieved from autistic children (cases) and neurotypical children (controls) in this work. A systematic review was conducted after the careful selection of published studies according to established criteria to gain a broad insight into the higher or lower levels of Pb in the biological materials of cases and controls, and the findings were then strengthened by a meta-analysis. The meta-analysis included 17 studies (hair), 13 studies (whole blood), and 8 studies (urine). The overall number of controls/cases was 869/915 (hair), 670/755 (whole blood), and 344/373 (urine). This meta-analysis showed significantly higher Pb levels in all three types of biological material in cases than in controls, suggesting a higher body Pb burden in autistic children. Thus, environmental Pb exposure could be related to the genesis of autism. Since no level of Pb can be considered safe, the data from this study undoubtedly point to the importance of regularly monitoring Pb levels in autistic children.",
publisher = "MDPI",
journal = "Toxics",
title = "Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis",
volume = "11",
number = "9",
pages = "753",
doi = "10.3390/toxics11090753"
}

Stojsavljević, A., Lakićević, N.,& Pavlović, S. Z.. (2023). Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis. in Toxics
MDPI., 11(9), 753.
https://doi.org/10.3390/toxics11090753

Stojsavljević A, Lakićević N, Pavlović SZ. Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis. in Toxics. 2023;11(9):753.
doi:10.3390/toxics11090753 .

Stojsavljević, Aleksandar, Lakićević, Novak, Pavlović, Slađan Z., "Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis" in Toxics, 11, no. 9 (2023):753,
https://doi.org/10.3390/toxics11090753 . .