TY  - JOUR
AU  - Zec, Manja
AU  - Srdić-Rajić, Tatjana
AU  - Konic-Ristic, Aleksandra
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Filipovic-Ljeskovic, Ivana
AU  - Radulović, Siniša
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1539
AB  - Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
VL  - 12
IS  - 9
SP  - 1071
EP  - 1080
DO  - 10.2174/187152012803529682
ER  - 

@article{
author = "Zec, Manja and Srdić-Rajić, Tatjana and Konic-Ristic, Aleksandra and Todorović, Tamara and Anđelković, Katarina K. and Filipovic-Ljeskovic, Ivana and Radulović, Siniša",
year = "2012",
abstract = "Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones",
volume = "12",
number = "9",
pages = "1071-1080",
doi = "10.2174/187152012803529682"
}

Zec, M., Srdić-Rajić, T., Konic-Ristic, A., Todorović, T., Anđelković, K. K., Filipovic-Ljeskovic, I.,& Radulović, S.. (2012). Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 12(9), 1071-1080.
https://doi.org/10.2174/187152012803529682

Zec M, Srdić-Rajić T, Konic-Ristic A, Todorović T, Anđelković KK, Filipovic-Ljeskovic I, Radulović S. Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry. 2012;12(9):1071-1080.
doi:10.2174/187152012803529682 .

Zec, Manja, Srdić-Rajić, Tatjana, Konic-Ristic, Aleksandra, Todorović, Tamara, Anđelković, Katarina K., Filipovic-Ljeskovic, Ivana, Radulović, Siniša, "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones" in Anti-Cancer Agents in Medicinal Chemistry, 12, no. 9 (2012):1071-1080,
https://doi.org/10.2174/187152012803529682 . .