TY  - JOUR
AU  - Cagnini, Caroline Zanella
AU  - Dias, Angélica Barbosa
AU  - Vilas Boas, Mariana Rodrigues
AU  - Batista, Fabiana Pacheco Reis
AU  - Faria, Maria Graciela Iecher
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Tešević, Vele
AU  - Ferreira, Ederlan de Souza
AU  - Colauto, Nelson Barros
AU  - Linde, Giani Andrea
AU  - Gazim, Zilda Cristiani
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5676
AB  - Bioactive compounds extracted from plants such as antimicrobials have attracted the attention of consumers and the food industry. This study aimed to determine the antimicrobial activity and chemical composition of Annona muricata leaf oleoresin obtained by supercritical CO2 extraction. The oleoresin was obtained by supercritical CO2 extraction and the chemical identification by gas chromatography coupled to mass spectrometry. Antimicrobial activity was evaluated by broth microdilution method against 14 foodborne fungi and bacteria. The oleoresin major chemical class was phytosterols (22.7%) and the major compounds were γ-sitosterol (15.7%), α-tocopherol (13.7%), phytol (13.1%), and hexadecanoic acid (11.5%). Minimum inhibitory concentration against bacteria ranged from 0.0025 to 0.010 mg mL−1. The oleoresin had high bactericidal activity against all bacteria, mainly Enterobacter cloacae and Pseudomonas aeruginosa with 0.005 mg mL−1 minimum bactericidal concentration. However, it had low fungicidal activity. The leaf oleoresin of A. muricata has promising applications in food, cosmetic, and pharmaceutical industries.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Antimicrobial activity of Annona muricata leaf oleoresin
VL  - 36
SP  - 4787
DO  - 10.1080/14786419.2021.2011270
ER  - 

@article{
author = "Cagnini, Caroline Zanella and Dias, Angélica Barbosa and Vilas Boas, Mariana Rodrigues and Batista, Fabiana Pacheco Reis and Faria, Maria Graciela Iecher and Glamočlija, Jasmina and Soković, Marina and Tešević, Vele and Ferreira, Ederlan de Souza and Colauto, Nelson Barros and Linde, Giani Andrea and Gazim, Zilda Cristiani",
year = "2022",
abstract = "Bioactive compounds extracted from plants such as antimicrobials have attracted the attention of consumers and the food industry. This study aimed to determine the antimicrobial activity and chemical composition of Annona muricata leaf oleoresin obtained by supercritical CO2 extraction. The oleoresin was obtained by supercritical CO2 extraction and the chemical identification by gas chromatography coupled to mass spectrometry. Antimicrobial activity was evaluated by broth microdilution method against 14 foodborne fungi and bacteria. The oleoresin major chemical class was phytosterols (22.7%) and the major compounds were γ-sitosterol (15.7%), α-tocopherol (13.7%), phytol (13.1%), and hexadecanoic acid (11.5%). Minimum inhibitory concentration against bacteria ranged from 0.0025 to 0.010 mg mL−1. The oleoresin had high bactericidal activity against all bacteria, mainly Enterobacter cloacae and Pseudomonas aeruginosa with 0.005 mg mL−1 minimum bactericidal concentration. However, it had low fungicidal activity. The leaf oleoresin of A. muricata has promising applications in food, cosmetic, and pharmaceutical industries.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Antimicrobial activity of Annona muricata leaf oleoresin",
volume = "36",
pages = "4787",
doi = "10.1080/14786419.2021.2011270"
}

Cagnini, C. Z., Dias, A. B., Vilas Boas, M. R., Batista, F. P. R., Faria, M. G. I., Glamočlija, J., Soković, M., Tešević, V., Ferreira, E. d. S., Colauto, N. B., Linde, G. A.,& Gazim, Z. C.. (2022). Antimicrobial activity of Annona muricata leaf oleoresin. in Natural Product Research
Taylor and Francis Ltd.., 36, 4787.
https://doi.org/10.1080/14786419.2021.2011270

Cagnini CZ, Dias AB, Vilas Boas MR, Batista FPR, Faria MGI, Glamočlija J, Soković M, Tešević V, Ferreira EDS, Colauto NB, Linde GA, Gazim ZC. Antimicrobial activity of Annona muricata leaf oleoresin. in Natural Product Research. 2022;36:4787.
doi:10.1080/14786419.2021.2011270 .

Cagnini, Caroline Zanella, Dias, Angélica Barbosa, Vilas Boas, Mariana Rodrigues, Batista, Fabiana Pacheco Reis, Faria, Maria Graciela Iecher, Glamočlija, Jasmina, Soković, Marina, Tešević, Vele, Ferreira, Ederlan de Souza, Colauto, Nelson Barros, Linde, Giani Andrea, Gazim, Zilda Cristiani, "Antimicrobial activity of Annona muricata leaf oleoresin" in Natural Product Research, 36 (2022):4787,
https://doi.org/10.1080/14786419.2021.2011270 . .

TY  - JOUR
AU  - Gazim, Zilda Cristiani
AU  - Rodrigues, Felipe
AU  - Lourenco Amorin, Ana Carolina
AU  - de Rezende, Claudia Moraes
AU  - Soković, Marina
AU  - Tešević, Vele
AU  - Vučković, Ivan M.
AU  - Krstić, Gordana B.
AU  - Ranieri Cortez, Lucia Elaine
AU  - Colauto, Nelson Barros
AU  - Linde, Giani Andrea
AU  - Garcia Cortez, Diogenes Aparicio
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1762
AB  - Tetradenia riparia (Hochstetter) Codd belongs to the Lamiaceae family and it was introduced in Brazil as an exotic ornamental plant. A previous study showed its antimicrobial, acaricidal and analgesic activities. Two compounds were isolated from essential oil of T. riparia leaves and identified as 9 beta, 13 beta-epoxy-7-abietene (1), a new one, and 6,7-dehydroroyleanone (2), already reported for another plant. The structure of these compounds was determined by spectroscopic analysis and by comparison with literature data. The cytotoxic activities of the essential oil and compounds 1 and 2 were determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and by tumor cells MDA-MB-435 (human breast carcinoma), HCT-8 (human colon), SF-295 (human nervous system) and HL-60 (human promyelocytic leukemia). The essential oil and compound 1 showed high cytotoxic potential of the cell lines SF-295 (78.06% and 94.80%, respectively), HCT-8 (85.00% and 86.54%, respectively) and MDA-MB-435 (59.48% and 45.43%, respectively). Compound 2 had no cytotoxic activity. The antioxidant activity was determined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH), beta-carotene-linoleic acid system and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The inhibitory concentration (IC50 in mu g mL(-1)) for essential oil and compound 2 was, respectively 15.63 and 0.01 for DPPH; 130.1 and 109.6 for beta-carotene-linoleic acid and 1524 and 1024 for ABTS. Compound 1 had no antioxidant activity. By fractioning the oil, it was possible to identify two unpublished compounds: 1 with high cytotoxic potential and 2 with high antioxidant potential.
PB  - Mdpi Ag, Basel
T2  - Molecules
T1  - New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities
VL  - 19
IS  - 1
SP  - 514
EP  - 524
DO  - 10.3390/molecules19010514
ER  - 

@article{
author = "Gazim, Zilda Cristiani and Rodrigues, Felipe and Lourenco Amorin, Ana Carolina and de Rezende, Claudia Moraes and Soković, Marina and Tešević, Vele and Vučković, Ivan M. and Krstić, Gordana B. and Ranieri Cortez, Lucia Elaine and Colauto, Nelson Barros and Linde, Giani Andrea and Garcia Cortez, Diogenes Aparicio",
year = "2014",
abstract = "Tetradenia riparia (Hochstetter) Codd belongs to the Lamiaceae family and it was introduced in Brazil as an exotic ornamental plant. A previous study showed its antimicrobial, acaricidal and analgesic activities. Two compounds were isolated from essential oil of T. riparia leaves and identified as 9 beta, 13 beta-epoxy-7-abietene (1), a new one, and 6,7-dehydroroyleanone (2), already reported for another plant. The structure of these compounds was determined by spectroscopic analysis and by comparison with literature data. The cytotoxic activities of the essential oil and compounds 1 and 2 were determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and by tumor cells MDA-MB-435 (human breast carcinoma), HCT-8 (human colon), SF-295 (human nervous system) and HL-60 (human promyelocytic leukemia). The essential oil and compound 1 showed high cytotoxic potential of the cell lines SF-295 (78.06% and 94.80%, respectively), HCT-8 (85.00% and 86.54%, respectively) and MDA-MB-435 (59.48% and 45.43%, respectively). Compound 2 had no cytotoxic activity. The antioxidant activity was determined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH), beta-carotene-linoleic acid system and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The inhibitory concentration (IC50 in mu g mL(-1)) for essential oil and compound 2 was, respectively 15.63 and 0.01 for DPPH; 130.1 and 109.6 for beta-carotene-linoleic acid and 1524 and 1024 for ABTS. Compound 1 had no antioxidant activity. By fractioning the oil, it was possible to identify two unpublished compounds: 1 with high cytotoxic potential and 2 with high antioxidant potential.",
publisher = "Mdpi Ag, Basel",
journal = "Molecules",
title = "New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities",
volume = "19",
number = "1",
pages = "514-524",
doi = "10.3390/molecules19010514"
}

Gazim, Z. C., Rodrigues, F., Lourenco Amorin, A. C., de Rezende, C. M., Soković, M., Tešević, V., Vučković, I. M., Krstić, G. B., Ranieri Cortez, L. E., Colauto, N. B., Linde, G. A.,& Garcia Cortez, D. A.. (2014). New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities. in Molecules
Mdpi Ag, Basel., 19(1), 514-524.
https://doi.org/10.3390/molecules19010514

Gazim ZC, Rodrigues F, Lourenco Amorin AC, de Rezende CM, Soković M, Tešević V, Vučković IM, Krstić GB, Ranieri Cortez LE, Colauto NB, Linde GA, Garcia Cortez DA. New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities. in Molecules. 2014;19(1):514-524.
doi:10.3390/molecules19010514 .

Gazim, Zilda Cristiani, Rodrigues, Felipe, Lourenco Amorin, Ana Carolina, de Rezende, Claudia Moraes, Soković, Marina, Tešević, Vele, Vučković, Ivan M., Krstić, Gordana B., Ranieri Cortez, Lucia Elaine, Colauto, Nelson Barros, Linde, Giani Andrea, Garcia Cortez, Diogenes Aparicio, "New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities" in Molecules, 19, no. 1 (2014):514-524,
https://doi.org/10.3390/molecules19010514 . .

TY  - JOUR
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Tešević, Vele
AU  - Linde, Giani Andrea
AU  - Colauto, Nelson Barros
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1250
AB  - The essential oil of Lippia alba is reported as an antifungal against human pathogenic microorganisms but few articles report its use as an alternative to synthetic fungicides on green mould control. The objective of this study was to determine chemical characteristics of L. alba essential oil and its antifungal activity against green molds as an alternative to synthetic fungicides. Essential oil was extracted by Clevenger hydrodistillation, characterized by GC-MS analysis, and the structure of the main compounds confirmed by H-1 and C-13-NMR spectroscopy. Microdilution assays evaluated the essential oil minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). Commercial fungicides Ketoconazole and Bifonazole were used as control. Essential oil yield is of 0.15% and the major components are neral (33.32%) and geranial (50.94%). The L. alba essential oil has MIC of 0.300-1.250 mg/mL and MFC of 0.600-1.250 mg/mL. Ketoconazole and Bifonazole show MIC ranging from 0.025-0.500 to 0.100-0.200 mg/mL, and MFC ranging from 0.250-0.100 to 0.200-0.250 mg/mL, respectively. L. alba essential oil is classified as citral type and the results indicate that it is a potential alternative to synthetic fungicides.
PB  - Soc Brasileira Microbiologia, Sao Paulo
T2  - Brazilian Journal of Microbiology
T1  - Chemical Characterization of Lippia Alba Essential Oil: An Alternative to Control Green Molds
VL  - 42
IS  - 4
SP  - 1537
EP  - 1546
DO  - 10.1590/S1517-83822011000400041
ER  - 

@article{
author = "Glamočlija, Jasmina and Soković, Marina and Tešević, Vele and Linde, Giani Andrea and Colauto, Nelson Barros",
year = "2011",
abstract = "The essential oil of Lippia alba is reported as an antifungal against human pathogenic microorganisms but few articles report its use as an alternative to synthetic fungicides on green mould control. The objective of this study was to determine chemical characteristics of L. alba essential oil and its antifungal activity against green molds as an alternative to synthetic fungicides. Essential oil was extracted by Clevenger hydrodistillation, characterized by GC-MS analysis, and the structure of the main compounds confirmed by H-1 and C-13-NMR spectroscopy. Microdilution assays evaluated the essential oil minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). Commercial fungicides Ketoconazole and Bifonazole were used as control. Essential oil yield is of 0.15% and the major components are neral (33.32%) and geranial (50.94%). The L. alba essential oil has MIC of 0.300-1.250 mg/mL and MFC of 0.600-1.250 mg/mL. Ketoconazole and Bifonazole show MIC ranging from 0.025-0.500 to 0.100-0.200 mg/mL, and MFC ranging from 0.250-0.100 to 0.200-0.250 mg/mL, respectively. L. alba essential oil is classified as citral type and the results indicate that it is a potential alternative to synthetic fungicides.",
publisher = "Soc Brasileira Microbiologia, Sao Paulo",
journal = "Brazilian Journal of Microbiology",
title = "Chemical Characterization of Lippia Alba Essential Oil: An Alternative to Control Green Molds",
volume = "42",
number = "4",
pages = "1537-1546",
doi = "10.1590/S1517-83822011000400041"
}

Glamočlija, J., Soković, M., Tešević, V., Linde, G. A.,& Colauto, N. B.. (2011). Chemical Characterization of Lippia Alba Essential Oil: An Alternative to Control Green Molds. in Brazilian Journal of Microbiology
Soc Brasileira Microbiologia, Sao Paulo., 42(4), 1537-1546.
https://doi.org/10.1590/S1517-83822011000400041

Glamočlija J, Soković M, Tešević V, Linde GA, Colauto NB. Chemical Characterization of Lippia Alba Essential Oil: An Alternative to Control Green Molds. in Brazilian Journal of Microbiology. 2011;42(4):1537-1546.
doi:10.1590/S1517-83822011000400041 .

Glamočlija, Jasmina, Soković, Marina, Tešević, Vele, Linde, Giani Andrea, Colauto, Nelson Barros, "Chemical Characterization of Lippia Alba Essential Oil: An Alternative to Control Green Molds" in Brazilian Journal of Microbiology, 42, no. 4 (2011):1537-1546,
https://doi.org/10.1590/S1517-83822011000400041 . .