TY  - DATA
AU  - Filipović, Nenad R.
AU  - Bjelogrlić, Snežana K.
AU  - Todorović, Tamara
AU  - Blagojević, Vladimir A.
AU  - Muller, Christian D.
AU  - Marinković, Aleksandar
AU  - Vujčić, Miroslava
AU  - Janović, Barbara
AU  - Malešević, Aleksandar
AU  - Begović, Nebojša
AU  - Senćanski, Milan
AU  - Minić, Dragica M.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3578
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Supplementary data for the article: Filipović, N. R.; Bjelogrlić, S.; Todorović, T. R.; Blagojević, V. A.; Muller, C. D.; Marinković, A.; Vujčić, M.; Janović, B.; Malešević, A. S.; Begović, N.; et al. Ni(II) Complex with Bishydrazone Ligand: Synthesis, Characterization, DNA Binding Studies and pro-Apoptotic and pro-Differentiation Induction in Human Cancerous Cell Lines. RSC Adv. 2016, 6 (110), 108726–108740. https://doi.org/10.1039/c6ra24604d
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3578
ER  - 

@misc{
author = "Filipović, Nenad R. and Bjelogrlić, Snežana K. and Todorović, Tamara and Blagojević, Vladimir A. and Muller, Christian D. and Marinković, Aleksandar and Vujčić, Miroslava and Janović, Barbara and Malešević, Aleksandar and Begović, Nebojša and Senćanski, Milan and Minić, Dragica M.",
year = "2016",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Supplementary data for the article: Filipović, N. R.; Bjelogrlić, S.; Todorović, T. R.; Blagojević, V. A.; Muller, C. D.; Marinković, A.; Vujčić, M.; Janović, B.; Malešević, A. S.; Begović, N.; et al. Ni(II) Complex with Bishydrazone Ligand: Synthesis, Characterization, DNA Binding Studies and pro-Apoptotic and pro-Differentiation Induction in Human Cancerous Cell Lines. RSC Adv. 2016, 6 (110), 108726–108740. https://doi.org/10.1039/c6ra24604d",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3578"
}

Filipović, N. R., Bjelogrlić, S. K., Todorović, T., Blagojević, V. A., Muller, C. D., Marinković, A., Vujčić, M., Janović, B., Malešević, A., Begović, N., Senćanski, M.,& Minić, D. M.. (2016). Supplementary data for the article: Filipović, N. R.; Bjelogrlić, S.; Todorović, T. R.; Blagojević, V. A.; Muller, C. D.; Marinković, A.; Vujčić, M.; Janović, B.; Malešević, A. S.; Begović, N.; et al. Ni(II) Complex with Bishydrazone Ligand: Synthesis, Characterization, DNA Binding Studies and pro-Apoptotic and pro-Differentiation Induction in Human Cancerous Cell Lines. RSC Adv. 2016, 6 (110), 108726–108740. https://doi.org/10.1039/c6ra24604d. in RSC Advances
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3578

Filipović NR, Bjelogrlić SK, Todorović T, Blagojević VA, Muller CD, Marinković A, Vujčić M, Janović B, Malešević A, Begović N, Senćanski M, Minić DM. Supplementary data for the article: Filipović, N. R.; Bjelogrlić, S.; Todorović, T. R.; Blagojević, V. A.; Muller, C. D.; Marinković, A.; Vujčić, M.; Janović, B.; Malešević, A. S.; Begović, N.; et al. Ni(II) Complex with Bishydrazone Ligand: Synthesis, Characterization, DNA Binding Studies and pro-Apoptotic and pro-Differentiation Induction in Human Cancerous Cell Lines. RSC Adv. 2016, 6 (110), 108726–108740. https://doi.org/10.1039/c6ra24604d. in RSC Advances. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3578 .

Filipović, Nenad R., Bjelogrlić, Snežana K., Todorović, Tamara, Blagojević, Vladimir A., Muller, Christian D., Marinković, Aleksandar, Vujčić, Miroslava, Janović, Barbara, Malešević, Aleksandar, Begović, Nebojša, Senćanski, Milan, Minić, Dragica M., "Supplementary data for the article: Filipović, N. R.; Bjelogrlić, S.; Todorović, T. R.; Blagojević, V. A.; Muller, C. D.; Marinković, A.; Vujčić, M.; Janović, B.; Malešević, A. S.; Begović, N.; et al. Ni(II) Complex with Bishydrazone Ligand: Synthesis, Characterization, DNA Binding Studies and pro-Apoptotic and pro-Differentiation Induction in Human Cancerous Cell Lines. RSC Adv. 2016, 6 (110), 108726–108740. https://doi.org/10.1039/c6ra24604d" in RSC Advances (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3578 .

TY  - JOUR
AU  - Filipović, Nenad R.
AU  - Bjelogrlić, Snežana K.
AU  - Todorović, Tamara
AU  - Blagojević, Vladimir A.
AU  - Muller, Christian D.
AU  - Marinković, Aleksandar
AU  - Vujčić, Miroslava
AU  - Janović, Barbara
AU  - Malešević, Aleksandar
AU  - Begović, Nebojša
AU  - Senćanski, Milan
AU  - Minić, Dragica M.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2362
AB  - A new Ni(II) complex, [Ni(L)(H2O)] (1), with diethyl 3,3'-(2,2'-(1,1'-(pyridine-2,6-diyl) bis(ethan-1-yl-1-ylidene)) bis(hydrazin-1-yl-2-ylidene)) bis(3-oxopropanoate) ligand (H2L) was synthesized as a potential chemotherapeutic agent. Polidentate ligand was coordinated to Ni(II) NNN-tridentately, in dianionic form, while monodentate water coordination completed square-planar geometry around metal. Structure in the solution was determined by NMR spectroscopy and the same coordination mode was observed in the solid state using IR spectroscopy and further verified by DFT calculations and electrochemical studies. Thermal stability of 1 was determined in both air and nitrogen atmosphere. Anticancer activity of 1 was investigated on acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma (AsPC-1) cell lines. On THP-1 cells 1 induced powerful apoptotic response (ED50 = 10 +/- 3 mu M), which was revealed to be only partially caspase-dependent, with activation of caspase-8 as the dominant course. This suggested that experimentally validated covalent binding of 1 to DNA is not the only mechanism responsible for programmed cell death. This was supported with experiments on AsPC-1 cells. Although treatment of those cells with 1 resulted in poor apoptotic response, cell cycle changes showed concentration-dependent shifts indicating a dual mechanism of activity. This study also reviews the results of preliminary biological screening, which demonstrates that 1 displays a unique pattern of anticancer activity with at least two mechanisms involved.
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines
VL  - 6
IS  - 110
SP  - 108726
EP  - 108740
DO  - 10.1039/c6ra24604d
ER  - 

@article{
author = "Filipović, Nenad R. and Bjelogrlić, Snežana K. and Todorović, Tamara and Blagojević, Vladimir A. and Muller, Christian D. and Marinković, Aleksandar and Vujčić, Miroslava and Janović, Barbara and Malešević, Aleksandar and Begović, Nebojša and Senćanski, Milan and Minić, Dragica M.",
year = "2016",
abstract = "A new Ni(II) complex, [Ni(L)(H2O)] (1), with diethyl 3,3'-(2,2'-(1,1'-(pyridine-2,6-diyl) bis(ethan-1-yl-1-ylidene)) bis(hydrazin-1-yl-2-ylidene)) bis(3-oxopropanoate) ligand (H2L) was synthesized as a potential chemotherapeutic agent. Polidentate ligand was coordinated to Ni(II) NNN-tridentately, in dianionic form, while monodentate water coordination completed square-planar geometry around metal. Structure in the solution was determined by NMR spectroscopy and the same coordination mode was observed in the solid state using IR spectroscopy and further verified by DFT calculations and electrochemical studies. Thermal stability of 1 was determined in both air and nitrogen atmosphere. Anticancer activity of 1 was investigated on acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma (AsPC-1) cell lines. On THP-1 cells 1 induced powerful apoptotic response (ED50 = 10 +/- 3 mu M), which was revealed to be only partially caspase-dependent, with activation of caspase-8 as the dominant course. This suggested that experimentally validated covalent binding of 1 to DNA is not the only mechanism responsible for programmed cell death. This was supported with experiments on AsPC-1 cells. Although treatment of those cells with 1 resulted in poor apoptotic response, cell cycle changes showed concentration-dependent shifts indicating a dual mechanism of activity. This study also reviews the results of preliminary biological screening, which demonstrates that 1 displays a unique pattern of anticancer activity with at least two mechanisms involved.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines",
volume = "6",
number = "110",
pages = "108726-108740",
doi = "10.1039/c6ra24604d"
}

Filipović, N. R., Bjelogrlić, S. K., Todorović, T., Blagojević, V. A., Muller, C. D., Marinković, A., Vujčić, M., Janović, B., Malešević, A., Begović, N., Senćanski, M.,& Minić, D. M.. (2016). Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines. in RSC Advances
Royal Soc Chemistry, Cambridge., 6(110), 108726-108740.
https://doi.org/10.1039/c6ra24604d

Filipović NR, Bjelogrlić SK, Todorović T, Blagojević VA, Muller CD, Marinković A, Vujčić M, Janović B, Malešević A, Begović N, Senćanski M, Minić DM. Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines. in RSC Advances. 2016;6(110):108726-108740.
doi:10.1039/c6ra24604d .

Filipović, Nenad R., Bjelogrlić, Snežana K., Todorović, Tamara, Blagojević, Vladimir A., Muller, Christian D., Marinković, Aleksandar, Vujčić, Miroslava, Janović, Barbara, Malešević, Aleksandar, Begović, Nebojša, Senćanski, Milan, Minić, Dragica M., "Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines" in RSC Advances, 6, no. 110 (2016):108726-108740,
https://doi.org/10.1039/c6ra24604d . .

TY  - JOUR
AU  - Begović, Nebojša
AU  - Blagojević, Vladimir A.
AU  - Ostojić, Sanja B.
AU  - Micić, Darko M.
AU  - Filipović, Nenad R.
AU  - Anđelković, Katarina K.
AU  - Minić, Dragica M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1862
AB  - Thermal stability of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands was investigated using a combination of experimental measurements and DFT calculations. All complexes exhibit a reversible second-order transition around 333 K, which can be attributed to structural reorganization of the ligand molecules. Thermal degradation begins in 570-610 K temperature region, with an endothermic peak, followed by exothermic peaks in DSC. TG measurements show a well-defined mass loss corresponding to the initial degradation, while subsequent processes are poorly separated. DFT calculations suggest that the initial degradation step occurs with release of Cl, which then reacts with remaining part of the complex molecule in an exothermic process. This leads to decomposition of the ligand molecule into four fragments corresponding to ethyl chloride, carbon dioxide, methyl amine, and the fragment with the aromatic group. Mass spectrum suggests that creation of these fragments most likely corresponds to the initial degradation, after which some of these coordinate to Pd center, whose coordination sphere is left incomplete by release of Cl. TG measurement to 1123 K indicates that the final degradation product at this temperature is palladium. (C) 2014 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Thermochimica Acta
T1  - Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands
VL  - 592
SP  - 23
EP  - 30
DO  - 10.1016/j.tca.2014.08.005
ER  - 

@article{
author = "Begović, Nebojša and Blagojević, Vladimir A. and Ostojić, Sanja B. and Micić, Darko M. and Filipović, Nenad R. and Anđelković, Katarina K. and Minić, Dragica M.",
year = "2014",
abstract = "Thermal stability of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands was investigated using a combination of experimental measurements and DFT calculations. All complexes exhibit a reversible second-order transition around 333 K, which can be attributed to structural reorganization of the ligand molecules. Thermal degradation begins in 570-610 K temperature region, with an endothermic peak, followed by exothermic peaks in DSC. TG measurements show a well-defined mass loss corresponding to the initial degradation, while subsequent processes are poorly separated. DFT calculations suggest that the initial degradation step occurs with release of Cl, which then reacts with remaining part of the complex molecule in an exothermic process. This leads to decomposition of the ligand molecule into four fragments corresponding to ethyl chloride, carbon dioxide, methyl amine, and the fragment with the aromatic group. Mass spectrum suggests that creation of these fragments most likely corresponds to the initial degradation, after which some of these coordinate to Pd center, whose coordination sphere is left incomplete by release of Cl. TG measurement to 1123 K indicates that the final degradation product at this temperature is palladium. (C) 2014 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Thermochimica Acta",
title = "Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands",
volume = "592",
pages = "23-30",
doi = "10.1016/j.tca.2014.08.005"
}

Begović, N., Blagojević, V. A., Ostojić, S. B., Micić, D. M., Filipović, N. R., Anđelković, K. K.,& Minić, D. M.. (2014). Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands. in Thermochimica Acta
Elsevier Science Bv, Amsterdam., 592, 23-30.
https://doi.org/10.1016/j.tca.2014.08.005

Begović N, Blagojević VA, Ostojić SB, Micić DM, Filipović NR, Anđelković KK, Minić DM. Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands. in Thermochimica Acta. 2014;592:23-30.
doi:10.1016/j.tca.2014.08.005 .

Begović, Nebojša, Blagojević, Vladimir A., Ostojić, Sanja B., Micić, Darko M., Filipović, Nenad R., Anđelković, Katarina K., Minić, Dragica M., "Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands" in Thermochimica Acta, 592 (2014):23-30,
https://doi.org/10.1016/j.tca.2014.08.005 . .