TY  - CONF
AU  - Cvijetić, Ilija
AU  - Ivković, Đurđa
AU  - Todorović, Petar
AU  - Andrić, Filip
AU  - Ristivojević, Petar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6222
AB  - DES are mixtures of a hydrogen bond donor (HBD) and a hydrogen bond acceptor (HBA) that, when combined in a specific molar ratio, exhibit a significant decrease in melting point and become liquid at room temperature. DES can be tailored to meet different physicochemical requirements by altering the HBA:HBD ratio or the nature of the compounds. In this study, we utilized the COSMO-RS method to predict the activity coefficients of 12 phenolic compounds in 105 NaDES. These NaDES contained equimolar mixtures of betaine, carnitine, creatine, and ornithine as HBAs and various sugars and amino acids as HBDs. The NaDES were compared to methanol, and several mixtures exhibited higher affinities to all phenolics. The most promising NaDES were betaine-glycerol, betaine-xylitol, and carnitine-urea. We are currently conducting experimental validation of the extraction efficiency of these cosmetically acceptable solvents. In summary, we have identified promising NaDES mixtures that could replace conventional solvents and contribute to the development of sustainable, bio-based extracts.

Acknowledgment: This research was funded by The Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program, No. 389927, and the MNTR, contracts No. 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.
C3  - 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia
T1  - Screening natural deep eutectic solvents (NaDES) using COSMO-RS for sustainable and environmentally-friendly cosmetic ingredients
IS  - 66
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6222
ER  - 

@conference{
author = "Cvijetić, Ilija and Ivković, Đurđa and Todorović, Petar and Andrić, Filip and Ristivojević, Petar",
year = "2023",
abstract = "DES are mixtures of a hydrogen bond donor (HBD) and a hydrogen bond acceptor (HBA) that, when combined in a specific molar ratio, exhibit a significant decrease in melting point and become liquid at room temperature. DES can be tailored to meet different physicochemical requirements by altering the HBA:HBD ratio or the nature of the compounds. In this study, we utilized the COSMO-RS method to predict the activity coefficients of 12 phenolic compounds in 105 NaDES. These NaDES contained equimolar mixtures of betaine, carnitine, creatine, and ornithine as HBAs and various sugars and amino acids as HBDs. The NaDES were compared to methanol, and several mixtures exhibited higher affinities to all phenolics. The most promising NaDES were betaine-glycerol, betaine-xylitol, and carnitine-urea. We are currently conducting experimental validation of the extraction efficiency of these cosmetically acceptable solvents. In summary, we have identified promising NaDES mixtures that could replace conventional solvents and contribute to the development of sustainable, bio-based extracts.

Acknowledgment: This research was funded by The Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program, No. 389927, and the MNTR, contracts No. 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.",
journal = "59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia",
title = "Screening natural deep eutectic solvents (NaDES) using COSMO-RS for sustainable and environmentally-friendly cosmetic ingredients",
number = "66",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6222"
}

Cvijetić, I., Ivković, Đ., Todorović, P., Andrić, F.,& Ristivojević, P.. (2023). Screening natural deep eutectic solvents (NaDES) using COSMO-RS for sustainable and environmentally-friendly cosmetic ingredients. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia(66).
https://hdl.handle.net/21.15107/rcub_cherry_6222

Cvijetić I, Ivković Đ, Todorović P, Andrić F, Ristivojević P. Screening natural deep eutectic solvents (NaDES) using COSMO-RS for sustainable and environmentally-friendly cosmetic ingredients. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia. 2023;(66).
https://hdl.handle.net/21.15107/rcub_cherry_6222 .

Cvijetić, Ilija, Ivković, Đurđa, Todorović, Petar, Andrić, Filip, Ristivojević, Petar, "Screening natural deep eutectic solvents (NaDES) using COSMO-RS for sustainable and environmentally-friendly cosmetic ingredients" in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia, no. 66 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6222 .

TY  - CONF
AU  - Ivković, Đurđa
AU  - Trifunović, Olga
AU  - Andrić, Filip
AU  - Krstić-Ristivojević, Maja
AU  - Ristivojević, Petar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6221
AB  - The latest studies show that UV and blue light, emitted by electronic devices with screens, slows the proliferation of the keratinocytes and generates free radicals leading to skin ageing1. Polyphenols, a compounds found in plants, can prevent light-induced damage to the skin. A constant screening of plant extracts is requisite in order to discern light-protective formulations to constitute cosmetic products. Using mass spectrometry, phenolic compounds were identified and quantified in plant extracts from 18 plants grown in Eastern Serbia. The cytotoxicity of the obtained extracts was tested on HaCaT cells (immortalized human keratinocytes) and IC50 values were determined. The obtained extracts are rich mixtures of phenolic compounds that must be dosed appropriately since they also damage skin cells at larger concentrations.

1. Nakashima Y, et al., Free Radic. Biol. Med. 2017, 108, 300–310.

Acknowledgment: This work was supported by The Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program, No.6389927, Ministry of Science, Technological Development and Innovation of Republic of Serbia Contract numbers 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.
C3  - 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia
T1  - Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties
IS  - 41
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6221
ER  - 

@conference{
author = "Ivković, Đurđa and Trifunović, Olga and Andrić, Filip and Krstić-Ristivojević, Maja and Ristivojević, Petar",
year = "2023",
abstract = "The latest studies show that UV and blue light, emitted by electronic devices with screens, slows the proliferation of the keratinocytes and generates free radicals leading to skin ageing1. Polyphenols, a compounds found in plants, can prevent light-induced damage to the skin. A constant screening of plant extracts is requisite in order to discern light-protective formulations to constitute cosmetic products. Using mass spectrometry, phenolic compounds were identified and quantified in plant extracts from 18 plants grown in Eastern Serbia. The cytotoxicity of the obtained extracts was tested on HaCaT cells (immortalized human keratinocytes) and IC50 values were determined. The obtained extracts are rich mixtures of phenolic compounds that must be dosed appropriately since they also damage skin cells at larger concentrations.

1. Nakashima Y, et al., Free Radic. Biol. Med. 2017, 108, 300–310.

Acknowledgment: This work was supported by The Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program, No.6389927, Ministry of Science, Technological Development and Innovation of Republic of Serbia Contract numbers 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.",
journal = "59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia",
title = "Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties",
number = "41",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6221"
}

Ivković, Đ., Trifunović, O., Andrić, F., Krstić-Ristivojević, M.,& Ristivojević, P.. (2023). Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia(41).
https://hdl.handle.net/21.15107/rcub_cherry_6221

Ivković Đ, Trifunović O, Andrić F, Krstić-Ristivojević M, Ristivojević P. Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia. 2023;(41).
https://hdl.handle.net/21.15107/rcub_cherry_6221 .

Ivković, Đurđa, Trifunović, Olga, Andrić, Filip, Krstić-Ristivojević, Maja, Ristivojević, Petar, "Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties" in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia, no. 41 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6221 .

TY  - DATA
AU  - Stanković, Mira
AU  - Prokopijević, Miloš
AU  - Šikoparija, Branko
AU  - Nedić, Nebojša
AU  - Andrić, Filip
AU  - Polović, Natalija
AU  - Natić, Maja
AU  - Radotić, Ksenija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5848
AB  - Varroa destructor is a parasitic mite responsible for the loss of honey bee (Apis mellifera) colonies. This study aimed to find a promising marker in honey for the bee colony infestation level using fluorescence spectroscopy and biochemical analyses. We examined whether the parameters of the honey samples’ fluorescence spectra and biochemical parameters, both related to proteins and phenolics, may be connected with the level of honey bee colonies’ infestation. The infestation level was highly positively correlated with the catalase activity in honey (r = 0.936). Additionally, the infestation level was positively correlated with the phenolic spectral component (r = 0.656), which was tentatively related to the phenolics in honey. No correlation was found between the diastase activity in honey and the colonies’ infestation level. The results indicate that the catalase activity in honey and the PFC1 spectral component may be reliable markers for the V. destructor infestation level of the colonies. The obtained data may be related to the honey yield obtained from the apiaries.
T2  - Foods
T2  - Foods
T1  - Supplementary material for: Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods, 12(3), 629.
https://doi.org/10.3390/foods12030629
VL  - 12
IS  - 3
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5848
ER  - 

@misc{
author = "Stanković, Mira and Prokopijević, Miloš and Šikoparija, Branko and Nedić, Nebojša and Andrić, Filip and Polović, Natalija and Natić, Maja and Radotić, Ksenija",
year = "2023",
abstract = "Varroa destructor is a parasitic mite responsible for the loss of honey bee (Apis mellifera) colonies. This study aimed to find a promising marker in honey for the bee colony infestation level using fluorescence spectroscopy and biochemical analyses. We examined whether the parameters of the honey samples’ fluorescence spectra and biochemical parameters, both related to proteins and phenolics, may be connected with the level of honey bee colonies’ infestation. The infestation level was highly positively correlated with the catalase activity in honey (r = 0.936). Additionally, the infestation level was positively correlated with the phenolic spectral component (r = 0.656), which was tentatively related to the phenolics in honey. No correlation was found between the diastase activity in honey and the colonies’ infestation level. The results indicate that the catalase activity in honey and the PFC1 spectral component may be reliable markers for the V. destructor infestation level of the colonies. The obtained data may be related to the honey yield obtained from the apiaries.",
journal = "Foods, Foods",
title = "Supplementary material for: Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods, 12(3), 629.
https://doi.org/10.3390/foods12030629",
volume = "12",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5848"
}

Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Supplementary material for: Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods, 12(3), 629.
https://doi.org/10.3390/foods12030629. in Foods, 12(3).
https://hdl.handle.net/21.15107/rcub_cherry_5848

Stanković M, Prokopijević M, Šikoparija B, Nedić N, Andrić F, Polović N, Natić M, Radotić K. Supplementary material for: Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods, 12(3), 629.
https://doi.org/10.3390/foods12030629. in Foods. 2023;12(3).
https://hdl.handle.net/21.15107/rcub_cherry_5848 .

Stanković, Mira, Prokopijević, Miloš, Šikoparija, Branko, Nedić, Nebojša, Andrić, Filip, Polović, Natalija, Natić, Maja, Radotić, Ksenija, "Supplementary material for: Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods, 12(3), 629.
https://doi.org/10.3390/foods12030629" in Foods, 12, no. 3 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_5848 .

TY  - JOUR
AU  - Stanković, Mira
AU  - Prokopijević, Miloš
AU  - Šikoparija, Branko
AU  - Nedić, Nebojša
AU  - Andrić, Filip
AU  - Polović, Natalija
AU  - Natić, Maja
AU  - Radotić, Ksenija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5847
AB  - Varroa destructor is a parasitic mite responsible for the loss of honey bee (Apis mellifera) colonies. This study aimed to find a promising marker in honey for the bee colony infestation level using fluorescence spectroscopy and biochemical analyses. We examined whether the parameters of the honey samples’ fluorescence spectra and biochemical parameters, both related to proteins and phenolics, may be connected with the level of honey bee colonies’ infestation. The infestation level was highly positively correlated with the catalase activity in honey (r = 0.936). Additionally, the infestation level was positively correlated with the phenolic spectral component (r = 0.656), which was tentatively related to the phenolics in honey. No correlation was found between the diastase activity in honey and the colonies’ infestation level. The results indicate that the catalase activity in honey and the PFC1 spectral component may be reliable markers for the V. destructor infestation level of the colonies. The obtained data may be related to the honey yield obtained from the apiaries.
T2  - Foods
T2  - Foods
T1  - Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies
VL  - 12
IS  - 3
SP  - 629
DO  - 10.3390/foods12030629
ER  - 

@article{
author = "Stanković, Mira and Prokopijević, Miloš and Šikoparija, Branko and Nedić, Nebojša and Andrić, Filip and Polović, Natalija and Natić, Maja and Radotić, Ksenija",
year = "2023",
abstract = "Varroa destructor is a parasitic mite responsible for the loss of honey bee (Apis mellifera) colonies. This study aimed to find a promising marker in honey for the bee colony infestation level using fluorescence spectroscopy and biochemical analyses. We examined whether the parameters of the honey samples’ fluorescence spectra and biochemical parameters, both related to proteins and phenolics, may be connected with the level of honey bee colonies’ infestation. The infestation level was highly positively correlated with the catalase activity in honey (r = 0.936). Additionally, the infestation level was positively correlated with the phenolic spectral component (r = 0.656), which was tentatively related to the phenolics in honey. No correlation was found between the diastase activity in honey and the colonies’ infestation level. The results indicate that the catalase activity in honey and the PFC1 spectral component may be reliable markers for the V. destructor infestation level of the colonies. The obtained data may be related to the honey yield obtained from the apiaries.",
journal = "Foods, Foods",
title = "Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies",
volume = "12",
number = "3",
pages = "629",
doi = "10.3390/foods12030629"
}

Stanković, M., Prokopijević, M., Šikoparija, B., Nedić, N., Andrić, F., Polović, N., Natić, M.,& Radotić, K.. (2023). Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods, 12(3), 629.
https://doi.org/10.3390/foods12030629

Stanković M, Prokopijević M, Šikoparija B, Nedić N, Andrić F, Polović N, Natić M, Radotić K. Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies. in Foods. 2023;12(3):629.
doi:10.3390/foods12030629 .

Stanković, Mira, Prokopijević, Miloš, Šikoparija, Branko, Nedić, Nebojša, Andrić, Filip, Polović, Natalija, Natić, Maja, Radotić, Ksenija, "Using Front-Face Fluorescence Spectroscopy and Biochemical
Analysis of Honey to Assess a Marker for the Level of Varroa
destructor Infestation of Honey Bee (Apis mellifera) Colonies" in Foods, 12, no. 3 (2023):629,
https://doi.org/10.3390/foods12030629 . .

TY  - JOUR
AU  - Ristivojević, Petar
AU  - Nešić, Jelena
AU  - Andrić, Filip
AU  - Nedić, Nebojša
AU  - Stanisavljević, Ljubiša
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5895
AB  - Propolis is a resinous natural substance collected by honeybees from different plant sources. The element content of propolis is influenced by the content of elements in the soil, climatic factors, and the degree of pollution. The aim of the study was to characterize element composition and content of toxic elements in 51 propolis collected from different locations in Serbia and to evaluate the differences among them. Determination of the 21 elements were performed using Inductively coupled plasma - optical emission spectrometry. K was the most abundant element, followed by Ca, Mg, Si, Fe, Zn, and Al. The microelements B, Ba, Mn, Na, Pb, and Ti were also present in propolis, while Co, Cr, Cu, Mo, Ni, Sr, and V were found in trace. Toxic elements such as Pb, As, and Cd were found in the trace. Kruskal-Wallis tests differentiate groups of samples by geographical origin. The presence of B, Fe, Sr, Ti, Zn, and As demonstrated statistical significance between six regions of Serbia.
PB  - Wiley
T2  - Chemistry & Biodiversity
T2  - Chemistry & Biodiversity
T1  - Elemental Profile of Propolis from Different Areas of Serbia
VL  - 20
IS  - 3
SP  - e202201140
DO  - 10.1002/cbdv.202201140
ER  - 

@article{
author = "Ristivojević, Petar and Nešić, Jelena and Andrić, Filip and Nedić, Nebojša and Stanisavljević, Ljubiša and Milojković-Opsenica, Dušanka and Trifković, Jelena",
year = "2023",
abstract = "Propolis is a resinous natural substance collected by honeybees from different plant sources. The element content of propolis is influenced by the content of elements in the soil, climatic factors, and the degree of pollution. The aim of the study was to characterize element composition and content of toxic elements in 51 propolis collected from different locations in Serbia and to evaluate the differences among them. Determination of the 21 elements were performed using Inductively coupled plasma - optical emission spectrometry. K was the most abundant element, followed by Ca, Mg, Si, Fe, Zn, and Al. The microelements B, Ba, Mn, Na, Pb, and Ti were also present in propolis, while Co, Cr, Cu, Mo, Ni, Sr, and V were found in trace. Toxic elements such as Pb, As, and Cd were found in the trace. Kruskal-Wallis tests differentiate groups of samples by geographical origin. The presence of B, Fe, Sr, Ti, Zn, and As demonstrated statistical significance between six regions of Serbia.",
publisher = "Wiley",
journal = "Chemistry & Biodiversity, Chemistry & Biodiversity",
title = "Elemental Profile of Propolis from Different Areas of Serbia",
volume = "20",
number = "3",
pages = "e202201140",
doi = "10.1002/cbdv.202201140"
}

Ristivojević, P., Nešić, J., Andrić, F., Nedić, N., Stanisavljević, L., Milojković-Opsenica, D.,& Trifković, J.. (2023). Elemental Profile of Propolis from Different Areas of Serbia. in Chemistry & Biodiversity
Wiley., 20(3), e202201140.
https://doi.org/10.1002/cbdv.202201140

Ristivojević P, Nešić J, Andrić F, Nedić N, Stanisavljević L, Milojković-Opsenica D, Trifković J. Elemental Profile of Propolis from Different Areas of Serbia. in Chemistry & Biodiversity. 2023;20(3):e202201140.
doi:10.1002/cbdv.202201140 .

Ristivojević, Petar, Nešić, Jelena, Andrić, Filip, Nedić, Nebojša, Stanisavljević, Ljubiša, Milojković-Opsenica, Dušanka, Trifković, Jelena, "Elemental Profile of Propolis from Different Areas of Serbia" in Chemistry & Biodiversity, 20, no. 3 (2023):e202201140,
https://doi.org/10.1002/cbdv.202201140 . .

TY  - JOUR
AU  - Horvacki, Nikola
AU  - Andrić, Filip
AU  - Gašić, Uroš M.
AU  - Đurović, Dejan
AU  - Tešić, Živoslav Lj.
AU  - Fotirić-Akšić, Milica M.
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5683
AB  - Domesticated international (standard) apple cultivars, together with resistant apple cultivars are the core of the Serbian apple production. Furthermore, autochthonous cultivars are characterized by a good adaptability to the local environmental conditions and represent a valuable source of genetic variability, as well as an important source of the gene pool for further breeding programs. Additionally, they show a higher phenolic content and a stronger antioxidant activity, in comparison to commercial cultivars. Therefore, they are more likely to be used as a functional food. The subjects of this study were seventeen samples of fruits and leaves from autochthonous apple cultivars, five international standard cultivars, and six resistant apple cultivars. The phenolic profile was determined using ultra-high performance liquid chromatography (UHPLC), coupled with a diode array detector and a TSQ Quantum Access Max triple-quadrupole mass spectrometer. A total of twenty compounds were quantified in the samples. Most of the analyzed phenolics were detected in higher amounts in the peel, compared to the mesocarp. The results of the multivariate analysis of variance (MANOVA) indicate that 5-O-caffeoylquinic acid is present in the highest amount in the mesocarp, while in the peel and leaves, quercetin-glycosides were detected in the highest amount. According to the MANOVA: phloretin, phlorizin, 5-O-caffeoylquinic acid, kaempferol, and p-coumaric acid are present in significantly higher levels in the autochthonous cultivars, compared to the standard and resistant ones (in both fruits and leaves). Therefore, these compounds can be used as chemical tracers of the apple varietal origin.
PB  - MDPI
T2  - Molecules
T1  - Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia
VL  - 27
IS  - 21
SP  - 7651
DO  - 10.3390/molecules27217651
ER  - 

@article{
author = "Horvacki, Nikola and Andrić, Filip and Gašić, Uroš M. and Đurović, Dejan and Tešić, Živoslav Lj. and Fotirić-Akšić, Milica M. and Milojković-Opsenica, Dušanka",
year = "2022",
abstract = "Domesticated international (standard) apple cultivars, together with resistant apple cultivars are the core of the Serbian apple production. Furthermore, autochthonous cultivars are characterized by a good adaptability to the local environmental conditions and represent a valuable source of genetic variability, as well as an important source of the gene pool for further breeding programs. Additionally, they show a higher phenolic content and a stronger antioxidant activity, in comparison to commercial cultivars. Therefore, they are more likely to be used as a functional food. The subjects of this study were seventeen samples of fruits and leaves from autochthonous apple cultivars, five international standard cultivars, and six resistant apple cultivars. The phenolic profile was determined using ultra-high performance liquid chromatography (UHPLC), coupled with a diode array detector and a TSQ Quantum Access Max triple-quadrupole mass spectrometer. A total of twenty compounds were quantified in the samples. Most of the analyzed phenolics were detected in higher amounts in the peel, compared to the mesocarp. The results of the multivariate analysis of variance (MANOVA) indicate that 5-O-caffeoylquinic acid is present in the highest amount in the mesocarp, while in the peel and leaves, quercetin-glycosides were detected in the highest amount. According to the MANOVA: phloretin, phlorizin, 5-O-caffeoylquinic acid, kaempferol, and p-coumaric acid are present in significantly higher levels in the autochthonous cultivars, compared to the standard and resistant ones (in both fruits and leaves). Therefore, these compounds can be used as chemical tracers of the apple varietal origin.",
publisher = "MDPI",
journal = "Molecules",
title = "Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia",
volume = "27",
number = "21",
pages = "7651",
doi = "10.3390/molecules27217651"
}

Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž. Lj., Fotirić-Akšić, M. M.,& Milojković-Opsenica, D.. (2022). Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. in Molecules
MDPI., 27(21), 7651.
https://doi.org/10.3390/molecules27217651

Horvacki N, Andrić F, Gašić UM, Đurović D, Tešić ŽL, Fotirić-Akšić MM, Milojković-Opsenica D. Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. in Molecules. 2022;27(21):7651.
doi:10.3390/molecules27217651 .

Horvacki, Nikola, Andrić, Filip, Gašić, Uroš M., Đurović, Dejan, Tešić, Živoslav Lj., Fotirić-Akšić, Milica M., Milojković-Opsenica, Dušanka, "Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia" in Molecules, 27, no. 21 (2022):7651,
https://doi.org/10.3390/molecules27217651 . .

TY  - DATA
AU  - Horvacki, Nikola
AU  - Andrić, Filip
AU  - Gašić, Uroš M.
AU  - Đurović, Dejan
AU  - Tešić, Živoslav Lj.
AU  - Fotirić-Akšić, Milica M.
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5701
AB  - Domesticated international (standard) apple cultivars, together with resistant apple cultivars are the core of the Serbian apple production. Furthermore, autochthonous cultivars are characterized by a good adaptability to the local environmental conditions and represent a valuable source of genetic variability, as well as an important source of the gene pool for further breeding programs. Additionally, they show a higher phenolic content and a stronger antioxidant activity, in comparison to commercial cultivars. Therefore, they are more likely to be used as a functional food. The subjects of this study were seventeen samples of fruits and leaves from autochthonous apple cultivars, five international standard cultivars, and six resistant apple cultivars. The phenolic profile was determined using ultra-high performance liquid chromatography (UHPLC), coupled with a diode array detector and a TSQ Quantum Access Max triple-quadrupole mass spectrometer. A total of twenty compounds were quantified in the samples. Most of the analyzed phenolics were detected in higher amounts in the peel, compared to the mesocarp. The results of the multivariate analysis of variance (MANOVA) indicate that 5-O-caffeoylquinic acid is present in the highest amount in the mesocarp, while in the peel and leaves, quercetin-glycosides were detected in the highest amount. According to the MANOVA: phloretin, phlorizin, 5-O-caffeoylquinic acid, kaempferol, and p-coumaric acid are present in significantly higher levels in the autochthonous cultivars, compared to the standard and resistant ones (in both fruits and leaves). Therefore, these compounds can be used as chemical tracers of the apple varietal origin.
PB  - MDPI
T2  - Molecules
T1  - Supplementary material for the article: Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž., Fotirić-Akšić, M. M., & Milojković-Opsenica, D. (2022). Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. Molecules, 27(21), 7651. https://doi.org/10.3390/molecules27217651
VL  - 27
IS  - 21
SP  - 7651
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5701
ER  - 

@misc{
author = "Horvacki, Nikola and Andrić, Filip and Gašić, Uroš M. and Đurović, Dejan and Tešić, Živoslav Lj. and Fotirić-Akšić, Milica M. and Milojković-Opsenica, Dušanka",
year = "2022",
abstract = "Domesticated international (standard) apple cultivars, together with resistant apple cultivars are the core of the Serbian apple production. Furthermore, autochthonous cultivars are characterized by a good adaptability to the local environmental conditions and represent a valuable source of genetic variability, as well as an important source of the gene pool for further breeding programs. Additionally, they show a higher phenolic content and a stronger antioxidant activity, in comparison to commercial cultivars. Therefore, they are more likely to be used as a functional food. The subjects of this study were seventeen samples of fruits and leaves from autochthonous apple cultivars, five international standard cultivars, and six resistant apple cultivars. The phenolic profile was determined using ultra-high performance liquid chromatography (UHPLC), coupled with a diode array detector and a TSQ Quantum Access Max triple-quadrupole mass spectrometer. A total of twenty compounds were quantified in the samples. Most of the analyzed phenolics were detected in higher amounts in the peel, compared to the mesocarp. The results of the multivariate analysis of variance (MANOVA) indicate that 5-O-caffeoylquinic acid is present in the highest amount in the mesocarp, while in the peel and leaves, quercetin-glycosides were detected in the highest amount. According to the MANOVA: phloretin, phlorizin, 5-O-caffeoylquinic acid, kaempferol, and p-coumaric acid are present in significantly higher levels in the autochthonous cultivars, compared to the standard and resistant ones (in both fruits and leaves). Therefore, these compounds can be used as chemical tracers of the apple varietal origin.",
publisher = "MDPI",
journal = "Molecules",
title = "Supplementary material for the article: Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž., Fotirić-Akšić, M. M., & Milojković-Opsenica, D. (2022). Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. Molecules, 27(21), 7651. https://doi.org/10.3390/molecules27217651",
volume = "27",
number = "21",
pages = "7651",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5701"
}

Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž. Lj., Fotirić-Akšić, M. M.,& Milojković-Opsenica, D.. (2022). Supplementary material for the article: Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž., Fotirić-Akšić, M. M., & Milojković-Opsenica, D. (2022). Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. Molecules, 27(21), 7651. https://doi.org/10.3390/molecules27217651. in Molecules
MDPI., 27(21), 7651.
https://hdl.handle.net/21.15107/rcub_cherry_5701

Horvacki N, Andrić F, Gašić UM, Đurović D, Tešić ŽL, Fotirić-Akšić MM, Milojković-Opsenica D. Supplementary material for the article: Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž., Fotirić-Akšić, M. M., & Milojković-Opsenica, D. (2022). Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. Molecules, 27(21), 7651. https://doi.org/10.3390/molecules27217651. in Molecules. 2022;27(21):7651.
https://hdl.handle.net/21.15107/rcub_cherry_5701 .

Horvacki, Nikola, Andrić, Filip, Gašić, Uroš M., Đurović, Dejan, Tešić, Živoslav Lj., Fotirić-Akšić, Milica M., Milojković-Opsenica, Dušanka, "Supplementary material for the article: Horvacki, N., Andrić, F., Gašić, U. M., Đurović, D., Tešić, Ž., Fotirić-Akšić, M. M., & Milojković-Opsenica, D. (2022). Phenolic Compounds as Phytochemical Tracers of Varietal Origin of Some Autochthonous Apple Cultivars Grown in Serbia. Molecules, 27(21), 7651. https://doi.org/10.3390/molecules27217651" in Molecules, 27, no. 21 (2022):7651,
https://hdl.handle.net/21.15107/rcub_cherry_5701 .

TY  - JOUR
AU  - Krstić, Đurđa
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Fotirić-Akšić, Milica M.
AU  - Đorđević, Boban
AU  - Milojković-Opsenica, Dušanka
AU  - Andrić, Filip
AU  - Trifković, Jelena
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5667
AB  - Research background. Considering the importance of consumption of berry fruits with
proven health-beneficial properties and difficulties in quality control of products of specific botanical and geographic origin, a fingerprint method was developed, based on advanced data analysis (pattern recognition, classification), in order to relate the variability
of nutrients in the selected cultivars to primary metabolite profile.
Experimental approach. Forty-five samples of genuine berry fruit cultivars (strawberry,
raspberry, blackberry, black currant, blueberry, gooseberry, chokeberry, cape gooseberry
and goji berry) were characterized according to chromatographic profiles of primary metabolites (sugars, lipids and fatty acids) obtained by three chromatographic techniques
(high-performance thin-layer chromatography, gas chromatography coupled to mass
spectrometry, and high-performance anion-exchange chromatography with pulsed amperometric detection).
Results and conclusions. Comprehensive analysis allowed monitoring and identification
of metabolites belonging to polar lipids, mono-, di- and triacylglycerols, free fatty acids,
free sterols, sterol esters, mono- to heptasaccharides and sugar alcohols. Chemical fingerprint of berry seeds showed the uniformity of primary metabolites within each fruit species, but revealed differences depending on the botanical origin. All three chromatographic methods provided a discriminative, informative and predictive metabolomics
methodology, which proved to be useful for chemotaxonomic classification.
Novelty and scientific contribution. A novel methodology for the identification of bioactive compounds from primary metabolites of natural products was described. The proposed untargeted metabolite profiling approach could be used in the future as a routine
method for tracing of novel bioactive compounds. The knowledge of metabolite composition obtained in this study can provide a better assessment of genotypic and phenotypic differences between berry fruit species and varieties, and could contribute to the development of new breeding programs.
PB  - University of Zagreb : Faculty of Food Technology and Biotechnology
T2  - Food Technology and Biotechnology
T1  - Primary Metabolite Chromatographic Profiling as a Tool for Chemotaxonomic Classification of Seeds from Berry Fruits
VL  - 60
IS  - 3
SP  - 406
EP  - 417
DO  - 10.17113/ftb.60.03.22.7505
ER  - 

@article{
author = "Krstić, Đurđa and Tosti, Tomislav and Đurović, Saša and Fotirić-Akšić, Milica M. and Đorđević, Boban and Milojković-Opsenica, Dušanka and Andrić, Filip and Trifković, Jelena",
year = "2022",
abstract = "Research background. Considering the importance of consumption of berry fruits with
proven health-beneficial properties and difficulties in quality control of products of specific botanical and geographic origin, a fingerprint method was developed, based on advanced data analysis (pattern recognition, classification), in order to relate the variability
of nutrients in the selected cultivars to primary metabolite profile.
Experimental approach. Forty-five samples of genuine berry fruit cultivars (strawberry,
raspberry, blackberry, black currant, blueberry, gooseberry, chokeberry, cape gooseberry
and goji berry) were characterized according to chromatographic profiles of primary metabolites (sugars, lipids and fatty acids) obtained by three chromatographic techniques
(high-performance thin-layer chromatography, gas chromatography coupled to mass
spectrometry, and high-performance anion-exchange chromatography with pulsed amperometric detection).
Results and conclusions. Comprehensive analysis allowed monitoring and identification
of metabolites belonging to polar lipids, mono-, di- and triacylglycerols, free fatty acids,
free sterols, sterol esters, mono- to heptasaccharides and sugar alcohols. Chemical fingerprint of berry seeds showed the uniformity of primary metabolites within each fruit species, but revealed differences depending on the botanical origin. All three chromatographic methods provided a discriminative, informative and predictive metabolomics
methodology, which proved to be useful for chemotaxonomic classification.
Novelty and scientific contribution. A novel methodology for the identification of bioactive compounds from primary metabolites of natural products was described. The proposed untargeted metabolite profiling approach could be used in the future as a routine
method for tracing of novel bioactive compounds. The knowledge of metabolite composition obtained in this study can provide a better assessment of genotypic and phenotypic differences between berry fruit species and varieties, and could contribute to the development of new breeding programs.",
publisher = "University of Zagreb : Faculty of Food Technology and Biotechnology",
journal = "Food Technology and Biotechnology",
title = "Primary Metabolite Chromatographic Profiling as a Tool for Chemotaxonomic Classification of Seeds from Berry Fruits",
volume = "60",
number = "3",
pages = "406-417",
doi = "10.17113/ftb.60.03.22.7505"
}

Krstić, Đ., Tosti, T., Đurović, S., Fotirić-Akšić, M. M., Đorđević, B., Milojković-Opsenica, D., Andrić, F.,& Trifković, J.. (2022). Primary Metabolite Chromatographic Profiling as a Tool for Chemotaxonomic Classification of Seeds from Berry Fruits. in Food Technology and Biotechnology
University of Zagreb : Faculty of Food Technology and Biotechnology., 60(3), 406-417.
https://doi.org/10.17113/ftb.60.03.22.7505

Krstić Đ, Tosti T, Đurović S, Fotirić-Akšić MM, Đorđević B, Milojković-Opsenica D, Andrić F, Trifković J. Primary Metabolite Chromatographic Profiling as a Tool for Chemotaxonomic Classification of Seeds from Berry Fruits. in Food Technology and Biotechnology. 2022;60(3):406-417.
doi:10.17113/ftb.60.03.22.7505 .

Krstić, Đurđa, Tosti, Tomislav, Đurović, Saša, Fotirić-Akšić, Milica M., Đorđević, Boban, Milojković-Opsenica, Dušanka, Andrić, Filip, Trifković, Jelena, "Primary Metabolite Chromatographic Profiling as a Tool for Chemotaxonomic Classification of Seeds from Berry Fruits" in Food Technology and Biotechnology, 60, no. 3 (2022):406-417,
https://doi.org/10.17113/ftb.60.03.22.7505 . .

TY  - DATA
AU  - Ristivojević, Petar
AU  - Andrić, Filip
AU  - Vasić, Vesna
AU  - Milojković-Opsenica, Dušanka
AU  - Morlock, Gertrud E.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5001
PB  - Elsevier
T2  - Food Chemistry
T1  - Supplementary data for the article: Ristivojević, P.; Andrić, F.; Vasić, V.; Milojković Opsenica, D.; Morlock, G. Fast Detection of Apricot Product Frauds by Added Pumpkin via Planar Chromatography and Chemometrics: Greenness Assessment by Analytical Eco-Scale. Food Chemistry 2022, 374 (131714). https://doi.org/10.1016/j.foodchem.2021.131714.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5001
ER  - 

@misc{
author = "Ristivojević, Petar and Andrić, Filip and Vasić, Vesna and Milojković-Opsenica, Dušanka and Morlock, Gertrud E.",
year = "2022",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Supplementary data for the article: Ristivojević, P.; Andrić, F.; Vasić, V.; Milojković Opsenica, D.; Morlock, G. Fast Detection of Apricot Product Frauds by Added Pumpkin via Planar Chromatography and Chemometrics: Greenness Assessment by Analytical Eco-Scale. Food Chemistry 2022, 374 (131714). https://doi.org/10.1016/j.foodchem.2021.131714.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5001"
}

Ristivojević, P., Andrić, F., Vasić, V., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Supplementary data for the article: Ristivojević, P.; Andrić, F.; Vasić, V.; Milojković Opsenica, D.; Morlock, G. Fast Detection of Apricot Product Frauds by Added Pumpkin via Planar Chromatography and Chemometrics: Greenness Assessment by Analytical Eco-Scale. Food Chemistry 2022, 374 (131714). https://doi.org/10.1016/j.foodchem.2021.131714.. in Food Chemistry
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_5001

Ristivojević P, Andrić F, Vasić V, Milojković-Opsenica D, Morlock GE. Supplementary data for the article: Ristivojević, P.; Andrić, F.; Vasić, V.; Milojković Opsenica, D.; Morlock, G. Fast Detection of Apricot Product Frauds by Added Pumpkin via Planar Chromatography and Chemometrics: Greenness Assessment by Analytical Eco-Scale. Food Chemistry 2022, 374 (131714). https://doi.org/10.1016/j.foodchem.2021.131714.. in Food Chemistry. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5001 .

Ristivojević, Petar, Andrić, Filip, Vasić, Vesna, Milojković-Opsenica, Dušanka, Morlock, Gertrud E., "Supplementary data for the article: Ristivojević, P.; Andrić, F.; Vasić, V.; Milojković Opsenica, D.; Morlock, G. Fast Detection of Apricot Product Frauds by Added Pumpkin via Planar Chromatography and Chemometrics: Greenness Assessment by Analytical Eco-Scale. Food Chemistry 2022, 374 (131714). https://doi.org/10.1016/j.foodchem.2021.131714." in Food Chemistry (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5001 .

TY  - JOUR
AU  - Ristivojević, Petar
AU  - Lekić, Nevena
AU  - Cvijetić, Ilija
AU  - Krstić, Đurđa
AU  - Andrić, Filip
AU  - Milojković-Opsenica, Dušanka
AU  - Morlock, Gertrud E.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5644
AB  - Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.
PB  - MDPI
T2  - Molecules
T1  - Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics
VL  - 27
SP  - 6062
DO  - 10.3390/molecules27186062
ER  - 

@article{
author = "Ristivojević, Petar and Lekić, Nevena and Cvijetić, Ilija and Krstić, Đurđa and Andrić, Filip and Milojković-Opsenica, Dušanka and Morlock, Gertrud E.",
year = "2022",
abstract = "Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.",
publisher = "MDPI",
journal = "Molecules",
title = "Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics",
volume = "27",
pages = "6062",
doi = "10.3390/molecules27186062"
}

Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules
MDPI., 27, 6062.
https://doi.org/10.3390/molecules27186062

Ristivojević P, Lekić N, Cvijetić I, Krstić Đ, Andrić F, Milojković-Opsenica D, Morlock GE. Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules. 2022;27:6062.
doi:10.3390/molecules27186062 .

Ristivojević, Petar, Lekić, Nevena, Cvijetić, Ilija, Krstić, Đurđa, Andrić, Filip, Milojković-Opsenica, Dušanka, Morlock, Gertrud E., "Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics" in Molecules, 27 (2022):6062,
https://doi.org/10.3390/molecules27186062 . .

TY  - DATA
AU  - Ristivojević, Petar
AU  - Lekić, Nevena
AU  - Cvijetić, Ilija
AU  - Krstić, Đurđa
AU  - Andrić, Filip
AU  - Milojković-Opsenica, Dušanka
AU  - Morlock, Gertrud E.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5646
AB  - Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.
PB  - MDPI
T2  - Molecules
T1  - Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062
VL  - 27
SP  - 6062
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5646
ER  - 

@misc{
author = "Ristivojević, Petar and Lekić, Nevena and Cvijetić, Ilija and Krstić, Đurđa and Andrić, Filip and Milojković-Opsenica, Dušanka and Morlock, Gertrud E.",
year = "2022",
abstract = "Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.",
publisher = "MDPI",
journal = "Molecules",
title = "Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062",
volume = "27",
pages = "6062",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5646"
}

Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062. in Molecules
MDPI., 27, 6062.
https://hdl.handle.net/21.15107/rcub_cherry_5646

Ristivojević P, Lekić N, Cvijetić I, Krstić Đ, Andrić F, Milojković-Opsenica D, Morlock GE. Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062. in Molecules. 2022;27:6062.
https://hdl.handle.net/21.15107/rcub_cherry_5646 .

Ristivojević, Petar, Lekić, Nevena, Cvijetić, Ilija, Krstić, Đurđa, Andrić, Filip, Milojković-Opsenica, Dušanka, Morlock, Gertrud E., "Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062" in Molecules, 27 (2022):6062,
https://hdl.handle.net/21.15107/rcub_cherry_5646 .

TY  - CONF
AU  - Ivković, Đurđa
AU  - Krstić-Ristivojević, Maja
AU  - Jankov, Milica
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Andrić, Filip
AU  - Ristivojević, Petar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6214
AB  - Excess of free radicals in skin causes oxidative stress, which results to skin aging and
appearance of age spots. The enzyme tyrosinase is responsible for mentioned process.
Slowing down of this unwanted process is one of the challenges of modern science. Thus,
the aim of this study is to examine the potential of selected plant extracts to reduce
oxidation stress and the appearance of hyperpigmentation. The extracts were characterized
by the use of high-performance thin-layer chromatography and high-performance liquid
chromatography coupled with mass spectrometry. The antioxidant activity of the extracts
and potential for the inhibition of tyrosinase enzyme were determined. Nineteen phenolic
compounds were quantificated in the tested extracts. The obtained results demonstrate that
the extracts of Morus alba (92%), Rubus (86%) and Agrimona eupatoria (84%) are the
most effective inhibitors. The Teucrium chamaedrys and Agrimona eupatoria showed high
values of antioxidant activity. The listed samples are commercial.
C3  - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings
T1  - Skin anti-ageing potential of 18 medicinal herbs collected from Serbia
IS  - 44
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6214
ER  - 

@conference{
author = "Ivković, Đurđa and Krstić-Ristivojević, Maja and Jankov, Milica and Milojković-Opsenica, Dušanka and Trifković, Jelena and Andrić, Filip and Ristivojević, Petar",
year = "2022",
abstract = "Excess of free radicals in skin causes oxidative stress, which results to skin aging and
appearance of age spots. The enzyme tyrosinase is responsible for mentioned process.
Slowing down of this unwanted process is one of the challenges of modern science. Thus,
the aim of this study is to examine the potential of selected plant extracts to reduce
oxidation stress and the appearance of hyperpigmentation. The extracts were characterized
by the use of high-performance thin-layer chromatography and high-performance liquid
chromatography coupled with mass spectrometry. The antioxidant activity of the extracts
and potential for the inhibition of tyrosinase enzyme were determined. Nineteen phenolic
compounds were quantificated in the tested extracts. The obtained results demonstrate that
the extracts of Morus alba (92%), Rubus (86%) and Agrimona eupatoria (84%) are the
most effective inhibitors. The Teucrium chamaedrys and Agrimona eupatoria showed high
values of antioxidant activity. The listed samples are commercial.",
journal = "58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings",
title = "Skin anti-ageing potential of 18 medicinal herbs collected from Serbia",
number = "44",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6214"
}

Ivković, Đ., Krstić-Ristivojević, M., Jankov, M., Milojković-Opsenica, D., Trifković, J., Andrić, F.,& Ristivojević, P.. (2022). Skin anti-ageing potential of 18 medicinal herbs collected from Serbia. in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings(44).
https://hdl.handle.net/21.15107/rcub_cherry_6214

Ivković Đ, Krstić-Ristivojević M, Jankov M, Milojković-Opsenica D, Trifković J, Andrić F, Ristivojević P. Skin anti-ageing potential of 18 medicinal herbs collected from Serbia. in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings. 2022;(44).
https://hdl.handle.net/21.15107/rcub_cherry_6214 .

Ivković, Đurđa, Krstić-Ristivojević, Maja, Jankov, Milica, Milojković-Opsenica, Dušanka, Trifković, Jelena, Andrić, Filip, Ristivojević, Petar, "Skin anti-ageing potential of 18 medicinal herbs collected from Serbia" in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings, no. 44 (2022),
https://hdl.handle.net/21.15107/rcub_cherry_6214 .

TY  - CONF
AU  - Imamoto, Minami
AU  - Jankov, Milica
AU  - Ristivojević, Petar
AU  - Trifković, Jelena
AU  - Milojković-Opsenica, Dušanka
AU  - Andrić, Filip
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6211
C3  - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings
T1  - HPTLC-guided optimization of ultrasound assisted extraction of polyphenols from green tea leaves (Camellia sinensis) using image analysis and multicriteria optimization
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6211
ER  - 

@conference{
author = "Imamoto, Minami and Jankov, Milica and Ristivojević, Petar and Trifković, Jelena and Milojković-Opsenica, Dušanka and Andrić, Filip",
year = "2022",
journal = "58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings",
title = "HPTLC-guided optimization of ultrasound assisted extraction of polyphenols from green tea leaves (Camellia sinensis) using image analysis and multicriteria optimization",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6211"
}

Imamoto, M., Jankov, M., Ristivojević, P., Trifković, J., Milojković-Opsenica, D.,& Andrić, F.. (2022). HPTLC-guided optimization of ultrasound assisted extraction of polyphenols from green tea leaves (Camellia sinensis) using image analysis and multicriteria optimization. in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings.
https://hdl.handle.net/21.15107/rcub_cherry_6211

Imamoto M, Jankov M, Ristivojević P, Trifković J, Milojković-Opsenica D, Andrić F. HPTLC-guided optimization of ultrasound assisted extraction of polyphenols from green tea leaves (Camellia sinensis) using image analysis and multicriteria optimization. in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_6211 .

Imamoto, Minami, Jankov, Milica, Ristivojević, Petar, Trifković, Jelena, Milojković-Opsenica, Dušanka, Andrić, Filip, "HPTLC-guided optimization of ultrasound assisted extraction of polyphenols from green tea leaves (Camellia sinensis) using image analysis and multicriteria optimization" in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings (2022),
https://hdl.handle.net/21.15107/rcub_cherry_6211 .

TY  - JOUR
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Ristivojević, Petar
AU  - Andrić, Filip
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4999
AB  - Quality control, nutritional value and the monitoring of hazardous residues in honey bee- products have become
major topics for both producers and consumers. Due to its potential role in human health, bee-products rich in
bioactive compounds are becoming increasingly popular. This review aims to provide an overview of thin-layer
chromatography methods used in quality control, authenticity testing and chemical profiling of bee-products in
order to help scientists engaged in the field of bee-products chemistry to utilize the advantages of this technique
in the detection and elimination of fraudulent practices in bee-product manufacturing. Recently, hyphenation of
thin-layer chromatography, image analysis and chemometrics support bee-products analysis by simultaneous determination of analytes with different detection principles, identification of individual
bioactive compounds as well as structure elucidation of compounds. Highlighted opportunities of thin-layer
chromatography could encourage further investigations that would lead to improvements in the detection and
elimination of marketing fraudulent practices.
PB  - Elsevier
T2  - Journal of Chromatography B
T1  - Thin-layer chromatography in the authenticity testing of bee-products
VL  - 1188
IS  - 123068
DO  - 10.1016/j.jchromb.2021.123068
ER  - 

@article{
author = "Milojković-Opsenica, Dušanka and Trifković, Jelena and Ristivojević, Petar and Andrić, Filip",
year = "2022",
abstract = "Quality control, nutritional value and the monitoring of hazardous residues in honey bee- products have become
major topics for both producers and consumers. Due to its potential role in human health, bee-products rich in
bioactive compounds are becoming increasingly popular. This review aims to provide an overview of thin-layer
chromatography methods used in quality control, authenticity testing and chemical profiling of bee-products in
order to help scientists engaged in the field of bee-products chemistry to utilize the advantages of this technique
in the detection and elimination of fraudulent practices in bee-product manufacturing. Recently, hyphenation of
thin-layer chromatography, image analysis and chemometrics support bee-products analysis by simultaneous determination of analytes with different detection principles, identification of individual
bioactive compounds as well as structure elucidation of compounds. Highlighted opportunities of thin-layer
chromatography could encourage further investigations that would lead to improvements in the detection and
elimination of marketing fraudulent practices.",
publisher = "Elsevier",
journal = "Journal of Chromatography B",
title = "Thin-layer chromatography in the authenticity testing of bee-products",
volume = "1188",
number = "123068",
doi = "10.1016/j.jchromb.2021.123068"
}

Milojković-Opsenica, D., Trifković, J., Ristivojević, P.,& Andrić, F.. (2022). Thin-layer chromatography in the authenticity testing of bee-products. in Journal of Chromatography B
Elsevier., 1188(123068).
https://doi.org/10.1016/j.jchromb.2021.123068

Milojković-Opsenica D, Trifković J, Ristivojević P, Andrić F. Thin-layer chromatography in the authenticity testing of bee-products. in Journal of Chromatography B. 2022;1188(123068).
doi:10.1016/j.jchromb.2021.123068 .

Milojković-Opsenica, Dušanka, Trifković, Jelena, Ristivojević, Petar, Andrić, Filip, "Thin-layer chromatography in the authenticity testing of bee-products" in Journal of Chromatography B, 1188, no. 123068 (2022),
https://doi.org/10.1016/j.jchromb.2021.123068 . .

TY  - JOUR
AU  - Ristivojević, Petar
AU  - Andrić, Filip
AU  - Vasić, Vesna
AU  - Milojković-Opsenica, Dušanka
AU  - Morlock, Gertrud E.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5000
AB  - The European Commission requires that fruit products distributed on the market meet standards of high quality and authenticity. For the quality assessment of apricot products susceptible to food fraud, an environmentally friendly, simple and cost-effective analytical profiling was developed by high-performance thin-layer chromatography multi-imaging (HPTLC-FLD/Vis). The new phytochemical profiling was applied for analysis of authentic samples (7 apricot and 5 pumpkin samples) and simulated adulterated products (11 mixture samples prepared by addition of 2.5–53% pooled pumpkin to pooled apricot). Based on the analytical eco-scale assessment, the HPTLC-FLD/Vis method was proven as an excellent green analytical method with low energy and solvent consumption. Chemometric data analysis confirmed the difference between apricot and apricot-pumpkin mixtures based on the phytochemical profile. Chemical markers responsible for their differentiation were identified. The results indicated that frauds by adding pumpkin to apricot products can be detected at added contents as low as 2.5%.
PB  - Elsevier
T2  - Food Chemistry
T1  - Fast detection of apricot product frauds by added pumpkin via planar chromatography and chemometrics: Greenness assessment by analytical eco-scale
VL  - 374
IS  - 131714
DO  - 10.1016/j.foodchem.2021.131714
ER  - 

@article{
author = "Ristivojević, Petar and Andrić, Filip and Vasić, Vesna and Milojković-Opsenica, Dušanka and Morlock, Gertrud E.",
year = "2022",
abstract = "The European Commission requires that fruit products distributed on the market meet standards of high quality and authenticity. For the quality assessment of apricot products susceptible to food fraud, an environmentally friendly, simple and cost-effective analytical profiling was developed by high-performance thin-layer chromatography multi-imaging (HPTLC-FLD/Vis). The new phytochemical profiling was applied for analysis of authentic samples (7 apricot and 5 pumpkin samples) and simulated adulterated products (11 mixture samples prepared by addition of 2.5–53% pooled pumpkin to pooled apricot). Based on the analytical eco-scale assessment, the HPTLC-FLD/Vis method was proven as an excellent green analytical method with low energy and solvent consumption. Chemometric data analysis confirmed the difference between apricot and apricot-pumpkin mixtures based on the phytochemical profile. Chemical markers responsible for their differentiation were identified. The results indicated that frauds by adding pumpkin to apricot products can be detected at added contents as low as 2.5%.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Fast detection of apricot product frauds by added pumpkin via planar chromatography and chemometrics: Greenness assessment by analytical eco-scale",
volume = "374",
number = "131714",
doi = "10.1016/j.foodchem.2021.131714"
}

Ristivojević, P., Andrić, F., Vasić, V., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Fast detection of apricot product frauds by added pumpkin via planar chromatography and chemometrics: Greenness assessment by analytical eco-scale. in Food Chemistry
Elsevier., 374(131714).
https://doi.org/10.1016/j.foodchem.2021.131714

Ristivojević P, Andrić F, Vasić V, Milojković-Opsenica D, Morlock GE. Fast detection of apricot product frauds by added pumpkin via planar chromatography and chemometrics: Greenness assessment by analytical eco-scale. in Food Chemistry. 2022;374(131714).
doi:10.1016/j.foodchem.2021.131714 .

Ristivojević, Petar, Andrić, Filip, Vasić, Vesna, Milojković-Opsenica, Dušanka, Morlock, Gertrud E., "Fast detection of apricot product frauds by added pumpkin via planar chromatography and chemometrics: Greenness assessment by analytical eco-scale" in Food Chemistry, 374, no. 131714 (2022),
https://doi.org/10.1016/j.foodchem.2021.131714 . .

TY  - CONF
AU  - Ristivojević, Petar
AU  - Jakanovski, Mihajlo V.
AU  - Andrić, Filip
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5233
UR  - https://27hskiki.hkd.hr/book-of-abstracts/
AB  - Upper-respiratory-tract infections (URTI) are contagious diseases caused by a variety of bacteria and viruses. Based on European Union reports for Serbia, usage of antibiotics in pediatrics is extremely high compared to other European countries. Thus, there is growing demand for herbal-based products for the prevention of URTI as an alternative for antibiotics. Due to therapeutic properties such as antimicrobial, cytotoxic, antioxidative, and anti-inflammatory Rubi idaei leaves were used in Serbian folk medicine against URTI. Additionally, commercially available herbal products most often comprise ethanolic extracts. However, high-alcohol content makes such products unsuitable for patients’ intolerant to alcohol, especially children or other sensitive group of patients. Due to mentioned drawbacks, proposed study was focus on the development of novel natural, edible, and safe alternative using NADES (Natural Deep Eutectic Solvent), as a new-generation solvents that resemble the plants’ intracellular environment. Due to the unique, tuneable solvation properties, NADES are getting more attention as solvents in natural product research.
This study aimed to present the green approach by using ultrasound assisted extraction and twenty various NADES systems as well as ethanol, methanol, and water as control solvents. The obtained extracts were evaluated in terms of their chemical composition by high-performance thin-layer chromatography (HPTLC), as well as in individual compounds by high-performance liquid chromatography (HPLC) coupled with mass spectrometry.
Chromatographic profiles revealed differences in chemical composition depending on the applied extraction system. Ten phenolic compounds such as chlorogenic acid, caffeic acid, rutin, isoquercetin, astragalin, isorhamnetin 3-O-glucoside, apigetrin, quercetin, kaempferol were quantified in Rubi Idaei leaves. Astragalin, isoquercetin, and rutin were major Consituents, while other compounds were found in minor amount. Kaempferol was found in high amount in almost all extracts, except in systems cholin chloride : glycerol with higher amount of water and cholin chloride : urea. Chemometric evaluation was applied to compare the extraction profile of NADES systems and their quantitative composition. Extraction systems discrimination revealed by principal component analysis confirming specific chemical profiles depending on the solvents used (Figure 1).
C3  - 27th Croatian Meeting of Chemists and Chemical Engineers with international participation
5th Symposium Vladimir Prelog 5 – 8 October 2021
Veli Lošinj, Croatia, Book of Abstracts
T1  - Natural deep eutectic solvent as extraction media for the main phenolic compounds from Rubi idaei leaves
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5233
ER  - 

@conference{
author = "Ristivojević, Petar and Jakanovski, Mihajlo V. and Andrić, Filip and Milojković-Opsenica, Dušanka and Trifković, Jelena",
year = "2021",
abstract = "Upper-respiratory-tract infections (URTI) are contagious diseases caused by a variety of bacteria and viruses. Based on European Union reports for Serbia, usage of antibiotics in pediatrics is extremely high compared to other European countries. Thus, there is growing demand for herbal-based products for the prevention of URTI as an alternative for antibiotics. Due to therapeutic properties such as antimicrobial, cytotoxic, antioxidative, and anti-inflammatory Rubi idaei leaves were used in Serbian folk medicine against URTI. Additionally, commercially available herbal products most often comprise ethanolic extracts. However, high-alcohol content makes such products unsuitable for patients’ intolerant to alcohol, especially children or other sensitive group of patients. Due to mentioned drawbacks, proposed study was focus on the development of novel natural, edible, and safe alternative using NADES (Natural Deep Eutectic Solvent), as a new-generation solvents that resemble the plants’ intracellular environment. Due to the unique, tuneable solvation properties, NADES are getting more attention as solvents in natural product research.
This study aimed to present the green approach by using ultrasound assisted extraction and twenty various NADES systems as well as ethanol, methanol, and water as control solvents. The obtained extracts were evaluated in terms of their chemical composition by high-performance thin-layer chromatography (HPTLC), as well as in individual compounds by high-performance liquid chromatography (HPLC) coupled with mass spectrometry.
Chromatographic profiles revealed differences in chemical composition depending on the applied extraction system. Ten phenolic compounds such as chlorogenic acid, caffeic acid, rutin, isoquercetin, astragalin, isorhamnetin 3-O-glucoside, apigetrin, quercetin, kaempferol were quantified in Rubi Idaei leaves. Astragalin, isoquercetin, and rutin were major Consituents, while other compounds were found in minor amount. Kaempferol was found in high amount in almost all extracts, except in systems cholin chloride : glycerol with higher amount of water and cholin chloride : urea. Chemometric evaluation was applied to compare the extraction profile of NADES systems and their quantitative composition. Extraction systems discrimination revealed by principal component analysis confirming specific chemical profiles depending on the solvents used (Figure 1).",
journal = "27th Croatian Meeting of Chemists and Chemical Engineers with international participation
5th Symposium Vladimir Prelog 5 – 8 October 2021
Veli Lošinj, Croatia, Book of Abstracts",
title = "Natural deep eutectic solvent as extraction media for the main phenolic compounds from Rubi idaei leaves",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5233"
}

Ristivojević, P., Jakanovski, M. V., Andrić, F., Milojković-Opsenica, D.,& Trifković, J.. (2021). Natural deep eutectic solvent as extraction media for the main phenolic compounds from Rubi idaei leaves. in 27th Croatian Meeting of Chemists and Chemical Engineers with international participation
5th Symposium Vladimir Prelog 5 – 8 October 2021
Veli Lošinj, Croatia, Book of Abstracts.
https://hdl.handle.net/21.15107/rcub_cherry_5233

Ristivojević P, Jakanovski MV, Andrić F, Milojković-Opsenica D, Trifković J. Natural deep eutectic solvent as extraction media for the main phenolic compounds from Rubi idaei leaves. in 27th Croatian Meeting of Chemists and Chemical Engineers with international participation
5th Symposium Vladimir Prelog 5 – 8 October 2021
Veli Lošinj, Croatia, Book of Abstracts. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_5233 .

Ristivojević, Petar, Jakanovski, Mihajlo V., Andrić, Filip, Milojković-Opsenica, Dušanka, Trifković, Jelena, "Natural deep eutectic solvent as extraction media for the main phenolic compounds from Rubi idaei leaves" in 27th Croatian Meeting of Chemists and Chemical Engineers with international participation
5th Symposium Vladimir Prelog 5 – 8 October 2021
Veli Lošinj, Croatia, Book of Abstracts (2021),
https://hdl.handle.net/21.15107/rcub_cherry_5233 .

TY  - CONF
AU  - Trifković, Jelena
AU  - Jović, Marko D.
AU  - Živković-Radovanović, Vukosava
AU  - Andrić, Filip
AU  - Ristivojević, Petar
AU  - Milojković-Opsenica, Dušanka
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5229
AB  - The guarantee of food safety and quality along the food chain has become an important issue which challenges the worldwide and attracts the extensive attention. In order to ensure food safety and quality, efficient analytical methodologies must be applied in the detection of food authenticity, origin, product quality control, food microbiology, genetically modified ingredients, pesticide residues, allergens and toxins.[1] The aim of this study was to develop a green, simple, and high throughput procedure for the quality assessment of food supplements using a high-performance thin-layer chromatography (HPTLC)/bioautography with multivariate statistics. Bioautography assays were developed for the identification of constituents with radical scavenging (DPPH assay), antimicrobial (Bacillus subtilis, Escherichia coli, Micrococus luteus), and enzymes (alpha-amylase) activities of different oregano samples (Figure 1). Further, the combination of chemical screening/bioprofiling and chemometrics was used for identification of target, most potent compounds and additionally, search of the most potent oregano samples. Due to several advantages such as minimum requirements for sample preparation and minimal amount of investigated sample, possibility of selection of eco-friendly and harmless organic solvents, in situ identification of target compounds, multi detection of investigated compounds, and low solvent consumption (200-500 μL per sample) planar chromatography/bioautography is recognized as green technique. Methodology suggested in this study confirmed its possible application in quality control of food supplements.
C3  - 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia
T1  - Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5229
ER  - 

@conference{
author = "Trifković, Jelena and Jović, Marko D. and Živković-Radovanović, Vukosava and Andrić, Filip and Ristivojević, Petar and Milojković-Opsenica, Dušanka",
year = "2021",
abstract = "The guarantee of food safety and quality along the food chain has become an important issue which challenges the worldwide and attracts the extensive attention. In order to ensure food safety and quality, efficient analytical methodologies must be applied in the detection of food authenticity, origin, product quality control, food microbiology, genetically modified ingredients, pesticide residues, allergens and toxins.[1] The aim of this study was to develop a green, simple, and high throughput procedure for the quality assessment of food supplements using a high-performance thin-layer chromatography (HPTLC)/bioautography with multivariate statistics. Bioautography assays were developed for the identification of constituents with radical scavenging (DPPH assay), antimicrobial (Bacillus subtilis, Escherichia coli, Micrococus luteus), and enzymes (alpha-amylase) activities of different oregano samples (Figure 1). Further, the combination of chemical screening/bioprofiling and chemometrics was used for identification of target, most potent compounds and additionally, search of the most potent oregano samples. Due to several advantages such as minimum requirements for sample preparation and minimal amount of investigated sample, possibility of selection of eco-friendly and harmless organic solvents, in situ identification of target compounds, multi detection of investigated compounds, and low solvent consumption (200-500 μL per sample) planar chromatography/bioautography is recognized as green technique. Methodology suggested in this study confirmed its possible application in quality control of food supplements.",
journal = "27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia",
title = "Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5229"
}

Trifković, J., Jović, M. D., Živković-Radovanović, V., Andrić, F., Ristivojević, P.,& Milojković-Opsenica, D.. (2021). Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare. in 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia.
https://hdl.handle.net/21.15107/rcub_cherry_5229

Trifković J, Jović MD, Živković-Radovanović V, Andrić F, Ristivojević P, Milojković-Opsenica D. Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare. in 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_5229 .

Trifković, Jelena, Jović, Marko D., Živković-Radovanović, Vukosava, Andrić, Filip, Ristivojević, Petar, Milojković-Opsenica, Dušanka, "Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare" in 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia (2021),
https://hdl.handle.net/21.15107/rcub_cherry_5229 .

TY  - CONF
AU  - Trifković, Jelena
AU  - Jović, Marko D.
AU  - Živković-Radovanović, Vukosava
AU  - Andrić, Filip
AU  - Ristivojević, Petar
AU  - Milojković-Opsenica, Dušanka
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5263
AB  - The guarantee of food safety and quality along the food chain has become an important issue which challenges the worldwide and attracts the extensive attention. In order to ensure food safety and quality, efficient analytical methodologies must be applied in the detection of food authenticity, origin, product quality control, food microbiology, genetically modified ingredients, pesticide residues, allergens and toxins.[1] The aim of this study was to develop a green, simple, and high throughput procedure for the quality assessment of food supplements using a high-performance thin-layer chromatography (HPTLC)/bioautography with multivariate statistics. Bioautography assays were developed for the identification of constituents with radical scavenging (DPPH assay), antimicrobial (Bacillus subtilis, Escherichia coli, Micrococus luteus), and enzymes (alpha-amylase) activities of different oregano samples (Figure 1). Further, the combination of chemical screening/bioprofiling and chemometrics was used for identification of target, most potent compounds and additionally, search of the most potent oregano samples. Due to several advantages such as minimum requirements for sample preparation and minimal amount of investigated sample, possibility of selection of eco-friendly and harmless organic solvents, in situ identification of target compounds, multi detection of investigated compounds, and low solvent consumption (200-500 μL per sample) planar chromatography/bioautography is recognized as green technique. Methodology suggested in this study confirmed its possible application in quality control of food supplements.
C3  - 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia
T1  - Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5263
ER  - 

@conference{
author = "Trifković, Jelena and Jović, Marko D. and Živković-Radovanović, Vukosava and Andrić, Filip and Ristivojević, Petar and Milojković-Opsenica, Dušanka",
year = "2021",
abstract = "The guarantee of food safety and quality along the food chain has become an important issue which challenges the worldwide and attracts the extensive attention. In order to ensure food safety and quality, efficient analytical methodologies must be applied in the detection of food authenticity, origin, product quality control, food microbiology, genetically modified ingredients, pesticide residues, allergens and toxins.[1] The aim of this study was to develop a green, simple, and high throughput procedure for the quality assessment of food supplements using a high-performance thin-layer chromatography (HPTLC)/bioautography with multivariate statistics. Bioautography assays were developed for the identification of constituents with radical scavenging (DPPH assay), antimicrobial (Bacillus subtilis, Escherichia coli, Micrococus luteus), and enzymes (alpha-amylase) activities of different oregano samples (Figure 1). Further, the combination of chemical screening/bioprofiling and chemometrics was used for identification of target, most potent compounds and additionally, search of the most potent oregano samples. Due to several advantages such as minimum requirements for sample preparation and minimal amount of investigated sample, possibility of selection of eco-friendly and harmless organic solvents, in situ identification of target compounds, multi detection of investigated compounds, and low solvent consumption (200-500 μL per sample) planar chromatography/bioautography is recognized as green technique. Methodology suggested in this study confirmed its possible application in quality control of food supplements.",
journal = "27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia",
title = "Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5263"
}

Trifković, J., Jović, M. D., Živković-Radovanović, V., Andrić, F., Ristivojević, P.,& Milojković-Opsenica, D.. (2021). Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare. in 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia.
https://hdl.handle.net/21.15107/rcub_cherry_5263

Trifković J, Jović MD, Živković-Radovanović V, Andrić F, Ristivojević P, Milojković-Opsenica D. Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare. in 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_5263 .

Trifković, Jelena, Jović, Marko D., Živković-Radovanović, Vukosava, Andrić, Filip, Ristivojević, Petar, Milojković-Opsenica, Dušanka, "Statistical analysis based green planar chromatographic methodology for quality control of food supplements: case study on Origanum vulgare" in 27th Croatian Meeting of Chemists and Chemical Engineers, 5–8 October 2021, Veli Lošinj, Croatia (2021),
https://hdl.handle.net/21.15107/rcub_cherry_5263 .

TY  - JOUR
AU  - Dramićanin, Aleksandra M.
AU  - Andrić, Filip
AU  - Mutić, Jelena
AU  - Stanković, Vesna
AU  - Momirović, Nebojša M.
AU  - Milojković-Opsenica, Dušanka
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4823
AB  - The effects of organic versus integral and conventional crop management on content and distribution of major and trace elements in different varieties of potato were investigated in a three year field trial. A set of 48 potato tubers of four varieties with different harvesting times, cultivated in three types of agricultural systems: conventional (C), integral (I), and organic (O) were characterized based on the composition of the elements of their bulk and peel. A total of 16 elements were quantified. In order to determine the source of variation among the types of production, parts of potato and varieties, multivariate analysis of variance (MANOVA) was conducted. The results indicate that Ca, Mg, and K may be considered as important indicators of the type of production, genotypes of potato, and harvesting time. Additionally, the analyses show that ten microelements are able to distinguish between production types and genotypes of potato.
PB  - Elsevier
T2  - Food Chemistry
T1  - Content and distribution of major and trace elements as a tool to assess the genotypes, harvesting time, and cultivation systems of potato
VL  - 354
SP  - 129507
DO  - 10.1016/j.foodchem.2021.129507
ER  - 

@article{
author = "Dramićanin, Aleksandra M. and Andrić, Filip and Mutić, Jelena and Stanković, Vesna and Momirović, Nebojša M. and Milojković-Opsenica, Dušanka",
year = "2021",
abstract = "The effects of organic versus integral and conventional crop management on content and distribution of major and trace elements in different varieties of potato were investigated in a three year field trial. A set of 48 potato tubers of four varieties with different harvesting times, cultivated in three types of agricultural systems: conventional (C), integral (I), and organic (O) were characterized based on the composition of the elements of their bulk and peel. A total of 16 elements were quantified. In order to determine the source of variation among the types of production, parts of potato and varieties, multivariate analysis of variance (MANOVA) was conducted. The results indicate that Ca, Mg, and K may be considered as important indicators of the type of production, genotypes of potato, and harvesting time. Additionally, the analyses show that ten microelements are able to distinguish between production types and genotypes of potato.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Content and distribution of major and trace elements as a tool to assess the genotypes, harvesting time, and cultivation systems of potato",
volume = "354",
pages = "129507",
doi = "10.1016/j.foodchem.2021.129507"
}

Dramićanin, A. M., Andrić, F., Mutić, J., Stanković, V., Momirović, N. M.,& Milojković-Opsenica, D.. (2021). Content and distribution of major and trace elements as a tool to assess the genotypes, harvesting time, and cultivation systems of potato. in Food Chemistry
Elsevier., 354, 129507.
https://doi.org/10.1016/j.foodchem.2021.129507

Dramićanin AM, Andrić F, Mutić J, Stanković V, Momirović NM, Milojković-Opsenica D. Content and distribution of major and trace elements as a tool to assess the genotypes, harvesting time, and cultivation systems of potato. in Food Chemistry. 2021;354:129507.
doi:10.1016/j.foodchem.2021.129507 .

Dramićanin, Aleksandra M., Andrić, Filip, Mutić, Jelena, Stanković, Vesna, Momirović, Nebojša M., Milojković-Opsenica, Dušanka, "Content and distribution of major and trace elements as a tool to assess the genotypes, harvesting time, and cultivation systems of potato" in Food Chemistry, 354 (2021):129507,
https://doi.org/10.1016/j.foodchem.2021.129507 . .

TY  - DATA
AU  - Dramićanin, Aleksandra M.
AU  - Andrić, Filip
AU  - Mutić, Jelena
AU  - Stanković, Vesna
AU  - Momirović, Nebojša M.
AU  - Milojković-Opsenica, Dušanka
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4824
PB  - Elsevier
T2  - Food Chemistry
T1  - Supplementary data for the article: Dramićanin, A.; Andrić, F.; Mutić, J.; Stanković, V.; Momirović, N.; Milojković-Opsenica, D. Content and Distribution of Major and Trace Elements as a Tool to Assess the Genotypes, Harvesting Time, and Cultivation Systems of Potato. Food Chemistry 2021, 354, 129507. https://doi.org/10.1016/j.foodchem.2021.129507.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4824
ER  - 

@misc{
author = "Dramićanin, Aleksandra M. and Andrić, Filip and Mutić, Jelena and Stanković, Vesna and Momirović, Nebojša M. and Milojković-Opsenica, Dušanka",
year = "2021",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Supplementary data for the article: Dramićanin, A.; Andrić, F.; Mutić, J.; Stanković, V.; Momirović, N.; Milojković-Opsenica, D. Content and Distribution of Major and Trace Elements as a Tool to Assess the Genotypes, Harvesting Time, and Cultivation Systems of Potato. Food Chemistry 2021, 354, 129507. https://doi.org/10.1016/j.foodchem.2021.129507.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4824"
}

Dramićanin, A. M., Andrić, F., Mutić, J., Stanković, V., Momirović, N. M.,& Milojković-Opsenica, D.. (2021). Supplementary data for the article: Dramićanin, A.; Andrić, F.; Mutić, J.; Stanković, V.; Momirović, N.; Milojković-Opsenica, D. Content and Distribution of Major and Trace Elements as a Tool to Assess the Genotypes, Harvesting Time, and Cultivation Systems of Potato. Food Chemistry 2021, 354, 129507. https://doi.org/10.1016/j.foodchem.2021.129507.. in Food Chemistry
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4824

Dramićanin AM, Andrić F, Mutić J, Stanković V, Momirović NM, Milojković-Opsenica D. Supplementary data for the article: Dramićanin, A.; Andrić, F.; Mutić, J.; Stanković, V.; Momirović, N.; Milojković-Opsenica, D. Content and Distribution of Major and Trace Elements as a Tool to Assess the Genotypes, Harvesting Time, and Cultivation Systems of Potato. Food Chemistry 2021, 354, 129507. https://doi.org/10.1016/j.foodchem.2021.129507.. in Food Chemistry. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4824 .

Dramićanin, Aleksandra M., Andrić, Filip, Mutić, Jelena, Stanković, Vesna, Momirović, Nebojša M., Milojković-Opsenica, Dušanka, "Supplementary data for the article: Dramićanin, A.; Andrić, F.; Mutić, J.; Stanković, V.; Momirović, N.; Milojković-Opsenica, D. Content and Distribution of Major and Trace Elements as a Tool to Assess the Genotypes, Harvesting Time, and Cultivation Systems of Potato. Food Chemistry 2021, 354, 129507. https://doi.org/10.1016/j.foodchem.2021.129507." in Food Chemistry (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4824 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Trišović, Nemanja
AU  - Andrić, Filip
AU  - Mladenović, Aleksandar
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4419
AB  - The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 µM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 µM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.
PB  - Springer International Publishing
T2  - Monatshefte für Chemie - Chemical Monthly
T2  - Monatshefte für Chemie - Chemical MonthlyMonatsh Chem
T1  - Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution
VL  - 152
IS  - 2
SP  - 185
EP  - 192
DO  - 10.1007/s00706-021-02745-3
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Trišović, Nemanja and Andrić, Filip and Mladenović, Aleksandar and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2021",
abstract = "The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 µM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 µM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.",
publisher = "Springer International Publishing",
journal = "Monatshefte für Chemie - Chemical Monthly, Monatshefte für Chemie - Chemical MonthlyMonatsh Chem",
title = "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution",
volume = "152",
number = "2",
pages = "185-192",
doi = "10.1007/s00706-021-02745-3"
}

Lović, J., Lađarević, J., Trišović, N., Andrić, F., Mladenović, A., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov Ivić, M.. (2021). Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly
Springer International Publishing., 152(2), 185-192.
https://doi.org/10.1007/s00706-021-02745-3

Lović J, Lađarević J, Trišović N, Andrić F, Mladenović A, Mijin D, Vuković D, Petrović SD, Avramov Ivić M. Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly. 2021;152(2):185-192.
doi:10.1007/s00706-021-02745-3 .

Lović, Jelena, Lađarević, Jelena, Trišović, Nemanja, Andrić, Filip, Mladenović, Aleksandar, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution" in Monatshefte für Chemie - Chemical Monthly, 152, no. 2 (2021):185-192,
https://doi.org/10.1007/s00706-021-02745-3 . .

TY  - JOUR
AU  - Ristivojević, Petar
AU  - Trifković, Jelena
AU  - Andrić, Filip
AU  - Milojković-Opsenica, Dušanka
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5198
AB  - In the current article, an overview of recent applications and opportunities of image evaluation of
high-performance thin-layer chromatograms (HPTLC) in food analysis and natural product
research is presented. The article shortly covers the aspects of specialized software packages for
image analysis, image post-correction, signal acquisition, and preprocessing. Contemporary aspects
of image-based HPTLC fingerprinting, quantification of target compounds, and advanced chemometric
modeling were reviewed. Special attention was dedicated to freely available software packages.
Advantages and disadvantages of each one were discussed in terms of abilities to obtain
chromatographic profiles and perform crucial steps in signal manipulation, such as background
subtraction, denoising, and background detrending. The most frequently applied techniques for
signal manipulation have been discussed and recommendation provided. In that sense, the article
aims to provide a valuable guideline for readers dealing with the application of HPTLC image analysis
in food and natural products research, especially in connection with the most frequently used
chemometric techniques, in domains of pattern recognition, classification, and regression.
PB  - Marcel Dekker
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Recent trends in image evaluation of HPTLC chromatograms
VL  - 43
SP  - 291
EP  - 299
DO  - 10.1080/10826076.2020.1725555
ER  - 

@article{
author = "Ristivojević, Petar and Trifković, Jelena and Andrić, Filip and Milojković-Opsenica, Dušanka",
year = "2020",
abstract = "In the current article, an overview of recent applications and opportunities of image evaluation of
high-performance thin-layer chromatograms (HPTLC) in food analysis and natural product
research is presented. The article shortly covers the aspects of specialized software packages for
image analysis, image post-correction, signal acquisition, and preprocessing. Contemporary aspects
of image-based HPTLC fingerprinting, quantification of target compounds, and advanced chemometric
modeling were reviewed. Special attention was dedicated to freely available software packages.
Advantages and disadvantages of each one were discussed in terms of abilities to obtain
chromatographic profiles and perform crucial steps in signal manipulation, such as background
subtraction, denoising, and background detrending. The most frequently applied techniques for
signal manipulation have been discussed and recommendation provided. In that sense, the article
aims to provide a valuable guideline for readers dealing with the application of HPTLC image analysis
in food and natural products research, especially in connection with the most frequently used
chemometric techniques, in domains of pattern recognition, classification, and regression.",
publisher = "Marcel Dekker",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Recent trends in image evaluation of HPTLC chromatograms",
volume = "43",
pages = "291-299",
doi = "10.1080/10826076.2020.1725555"
}

Ristivojević, P., Trifković, J., Andrić, F.,& Milojković-Opsenica, D.. (2020). Recent trends in image evaluation of HPTLC chromatograms. in Journal of Liquid Chromatography & Related Technologies
Marcel Dekker., 43, 291-299.
https://doi.org/10.1080/10826076.2020.1725555

Ristivojević P, Trifković J, Andrić F, Milojković-Opsenica D. Recent trends in image evaluation of HPTLC chromatograms. in Journal of Liquid Chromatography & Related Technologies. 2020;43:291-299.
doi:10.1080/10826076.2020.1725555 .

Ristivojević, Petar, Trifković, Jelena, Andrić, Filip, Milojković-Opsenica, Dušanka, "Recent trends in image evaluation of HPTLC chromatograms" in Journal of Liquid Chromatography & Related Technologies, 43 (2020):291-299,
https://doi.org/10.1080/10826076.2020.1725555 . .

TY  - JOUR
AU  - Ciura, Krzesimir
AU  - Fedorowicz, Joanna
AU  - Andrić, Filip
AU  - Žuvela, Petar
AU  - Greber, Katarzyna Ewa
AU  - Baranowski, Paweł
AU  - Kawczak, Piotr
AU  - Nowakowska, Joanna
AU  - Baçzek, Tomasz
AU  - Saçzewski, Jarosław
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3764
AB  - The lipophilicity of a molecule is a well-recognized as a crucial physicochemical factor that conditions the biological activity of a drug candidate. This study was aimed to evaluate the lipophilicity of isoxazolo[3,4-b]pyridine-3(1H)-ones and their N1-substituted derivatives, which demonstrated pronounced antifungal activities. Several methods, including reversed-phase thin layer chromatography (RP-TLC), reversed phase high-performance liquid chromatography (RP-HPLC), and micellar electrokinetic chromatography (MEKC), were employed. Furthermore, the calculated logP values were estimated using various freely and commercially available software packages and online platforms, as well as density functional theory computations (DFT). Similarities and dissimilarities between the determined lipophilicity indices were assessed using several chemometric approaches. Principal component analysis (PCA) indicated that other features beside lipophilicity affect antifungal activities of the investigated derivatives. Quantitative-structure-retention-relationship (QSRR) analysis by means of genetic algorithm - partial least squares (GA-PLS) - was implemented to rationalize the link between the physicochemical descriptors and lipophilicity. Among the studied compounds, structure 16 should be considered as the best starting structure for further studies, since it demonstrated the lowest lipophilic character within the series while retaining biological activity. Sum of ranking differences (SRD) analysis indicated that the chromatographic approach, regardless of the technique employed, should be considered as the best approach for lipophilicity assessment of isoxazolones.
T2  - Molecules
T1  - Lipophilicity determination of antifungal isoxazolo[3,4-b]pyridin-3(1h)-ones and their n1-substituted derivatives with chromatographic and computational methods
VL  - 24
IS  - 23
SP  - 1
EP  - 22
DO  - 10.3390/molecules24234311
ER  - 

@article{
author = "Ciura, Krzesimir and Fedorowicz, Joanna and Andrić, Filip and Žuvela, Petar and Greber, Katarzyna Ewa and Baranowski, Paweł and Kawczak, Piotr and Nowakowska, Joanna and Baçzek, Tomasz and Saçzewski, Jarosław",
year = "2019",
abstract = "The lipophilicity of a molecule is a well-recognized as a crucial physicochemical factor that conditions the biological activity of a drug candidate. This study was aimed to evaluate the lipophilicity of isoxazolo[3,4-b]pyridine-3(1H)-ones and their N1-substituted derivatives, which demonstrated pronounced antifungal activities. Several methods, including reversed-phase thin layer chromatography (RP-TLC), reversed phase high-performance liquid chromatography (RP-HPLC), and micellar electrokinetic chromatography (MEKC), were employed. Furthermore, the calculated logP values were estimated using various freely and commercially available software packages and online platforms, as well as density functional theory computations (DFT). Similarities and dissimilarities between the determined lipophilicity indices were assessed using several chemometric approaches. Principal component analysis (PCA) indicated that other features beside lipophilicity affect antifungal activities of the investigated derivatives. Quantitative-structure-retention-relationship (QSRR) analysis by means of genetic algorithm - partial least squares (GA-PLS) - was implemented to rationalize the link between the physicochemical descriptors and lipophilicity. Among the studied compounds, structure 16 should be considered as the best starting structure for further studies, since it demonstrated the lowest lipophilic character within the series while retaining biological activity. Sum of ranking differences (SRD) analysis indicated that the chromatographic approach, regardless of the technique employed, should be considered as the best approach for lipophilicity assessment of isoxazolones.",
journal = "Molecules",
title = "Lipophilicity determination of antifungal isoxazolo[3,4-b]pyridin-3(1h)-ones and their n1-substituted derivatives with chromatographic and computational methods",
volume = "24",
number = "23",
pages = "1-22",
doi = "10.3390/molecules24234311"
}

Ciura, K., Fedorowicz, J., Andrić, F., Žuvela, P., Greber, K. E., Baranowski, P., Kawczak, P., Nowakowska, J., Baçzek, T.,& Saçzewski, J.. (2019). Lipophilicity determination of antifungal isoxazolo[3,4-b]pyridin-3(1h)-ones and their n1-substituted derivatives with chromatographic and computational methods. in Molecules, 24(23), 1-22.
https://doi.org/10.3390/molecules24234311

Ciura K, Fedorowicz J, Andrić F, Žuvela P, Greber KE, Baranowski P, Kawczak P, Nowakowska J, Baçzek T, Saçzewski J. Lipophilicity determination of antifungal isoxazolo[3,4-b]pyridin-3(1h)-ones and their n1-substituted derivatives with chromatographic and computational methods. in Molecules. 2019;24(23):1-22.
doi:10.3390/molecules24234311 .

Ciura, Krzesimir, Fedorowicz, Joanna, Andrić, Filip, Žuvela, Petar, Greber, Katarzyna Ewa, Baranowski, Paweł, Kawczak, Piotr, Nowakowska, Joanna, Baçzek, Tomasz, Saçzewski, Jarosław, "Lipophilicity determination of antifungal isoxazolo[3,4-b]pyridin-3(1h)-ones and their n1-substituted derivatives with chromatographic and computational methods" in Molecules, 24, no. 23 (2019):1-22,
https://doi.org/10.3390/molecules24234311 . .

TY  - JOUR
AU  - Ciura, Krzesimir
AU  - Fedorowicz, Joanna
AU  - Andrić, Filip
AU  - Greber, Katarzyna E.
AU  - Gurgielewicz, Alina
AU  - Sawicki, Wiesław
AU  - Saczewski, Jaroslaw
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3740
AB  - Lipophilicity is a vital physicochemical parameter of a molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties. In this study, evaluation of lipophilicities of a series of novel fluoroquinolone-Safirinium dye hybrids using chromatographic and computational methods is presented. Fluoroquinolone-Safirinium dye hybrids have been synthesized as new dual-acting hydrophilic antibacterial agents. Reversed phase thin-layer chromatography and micellar electrokinetic chromatography experiments were carried out. Furthermore, logP values of the target structures were predicted by means of different software platforms and algorithms. In order to assess similarities and dissimilarities of the obtained lipophilicity indexes, cluster analysis and sum of ranking differences were performed. The significant differences of calculated logP values (α = 0.05, p < 0.001) indicated that an experimental approach is necessary for lipophilicity prediction of this class of antibiotics. Chromatographic data indicated that the newly synthesized hybrid (fluoro)quinolone-based quaternary ammonium derivatives show less lipophilic character than the parent (fluoro)quinolones. Additionally, the chromatographically obtained lipophilicity indexes were evaluated for possible application in quantitative retention–activity relationships. The established lipophilicity models have the potential to predict antimicrobial activities of a series of quaternary (fluoro)quinolones against Bacillus subtilis, Escherichia coli, and Proteus vulgaris.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Lipophilicity determination of quaternary (Fluoro)quinolones by chromatographic and theoretical approaches
VL  - 20
IS  - 21
DO  - 10.3390/ijms20215288
ER  - 

@article{
author = "Ciura, Krzesimir and Fedorowicz, Joanna and Andrić, Filip and Greber, Katarzyna E. and Gurgielewicz, Alina and Sawicki, Wiesław and Saczewski, Jaroslaw",
year = "2019",
abstract = "Lipophilicity is a vital physicochemical parameter of a molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties. In this study, evaluation of lipophilicities of a series of novel fluoroquinolone-Safirinium dye hybrids using chromatographic and computational methods is presented. Fluoroquinolone-Safirinium dye hybrids have been synthesized as new dual-acting hydrophilic antibacterial agents. Reversed phase thin-layer chromatography and micellar electrokinetic chromatography experiments were carried out. Furthermore, logP values of the target structures were predicted by means of different software platforms and algorithms. In order to assess similarities and dissimilarities of the obtained lipophilicity indexes, cluster analysis and sum of ranking differences were performed. The significant differences of calculated logP values (α = 0.05, p < 0.001) indicated that an experimental approach is necessary for lipophilicity prediction of this class of antibiotics. Chromatographic data indicated that the newly synthesized hybrid (fluoro)quinolone-based quaternary ammonium derivatives show less lipophilic character than the parent (fluoro)quinolones. Additionally, the chromatographically obtained lipophilicity indexes were evaluated for possible application in quantitative retention–activity relationships. The established lipophilicity models have the potential to predict antimicrobial activities of a series of quaternary (fluoro)quinolones against Bacillus subtilis, Escherichia coli, and Proteus vulgaris.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Lipophilicity determination of quaternary (Fluoro)quinolones by chromatographic and theoretical approaches",
volume = "20",
number = "21",
doi = "10.3390/ijms20215288"
}

Ciura, K., Fedorowicz, J., Andrić, F., Greber, K. E., Gurgielewicz, A., Sawicki, W.,& Saczewski, J.. (2019). Lipophilicity determination of quaternary (Fluoro)quinolones by chromatographic and theoretical approaches. in International Journal of Molecular Sciences
MDPI., 20(21).
https://doi.org/10.3390/ijms20215288

Ciura K, Fedorowicz J, Andrić F, Greber KE, Gurgielewicz A, Sawicki W, Saczewski J. Lipophilicity determination of quaternary (Fluoro)quinolones by chromatographic and theoretical approaches. in International Journal of Molecular Sciences. 2019;20(21).
doi:10.3390/ijms20215288 .

Ciura, Krzesimir, Fedorowicz, Joanna, Andrić, Filip, Greber, Katarzyna E., Gurgielewicz, Alina, Sawicki, Wiesław, Saczewski, Jaroslaw, "Lipophilicity determination of quaternary (Fluoro)quinolones by chromatographic and theoretical approaches" in International Journal of Molecular Sciences, 20, no. 21 (2019),
https://doi.org/10.3390/ijms20215288 . .

TY  - DATA
AU  - Ciura, Krzesimir
AU  - Fedorowicz, Joanna
AU  - Andrić, Filip
AU  - Greber, Katarzyna E.
AU  - Gurgielewicz, Alina
AU  - Sawicki, Wiesław
AU  - Saczewski, Jaroslaw
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3741
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Supplementary data for the article: Ciura, K.; Fedorowicz, J.; Andrić, F.; Greber, K. E.; Gurgielewicz, A.; Sawicki, W.; Saczewski, J. Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches. International Journal of Molecular Sciences 2019, 20 (21). https://doi.org/10.3390/ijms20215288
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3741
ER  - 

@misc{
author = "Ciura, Krzesimir and Fedorowicz, Joanna and Andrić, Filip and Greber, Katarzyna E. and Gurgielewicz, Alina and Sawicki, Wiesław and Saczewski, Jaroslaw",
year = "2019",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Supplementary data for the article: Ciura, K.; Fedorowicz, J.; Andrić, F.; Greber, K. E.; Gurgielewicz, A.; Sawicki, W.; Saczewski, J. Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches. International Journal of Molecular Sciences 2019, 20 (21). https://doi.org/10.3390/ijms20215288",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3741"
}

Ciura, K., Fedorowicz, J., Andrić, F., Greber, K. E., Gurgielewicz, A., Sawicki, W.,& Saczewski, J.. (2019). Supplementary data for the article: Ciura, K.; Fedorowicz, J.; Andrić, F.; Greber, K. E.; Gurgielewicz, A.; Sawicki, W.; Saczewski, J. Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches. International Journal of Molecular Sciences 2019, 20 (21). https://doi.org/10.3390/ijms20215288. in International Journal of Molecular Sciences
MDPI..
https://hdl.handle.net/21.15107/rcub_cherry_3741

Ciura K, Fedorowicz J, Andrić F, Greber KE, Gurgielewicz A, Sawicki W, Saczewski J. Supplementary data for the article: Ciura, K.; Fedorowicz, J.; Andrić, F.; Greber, K. E.; Gurgielewicz, A.; Sawicki, W.; Saczewski, J. Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches. International Journal of Molecular Sciences 2019, 20 (21). https://doi.org/10.3390/ijms20215288. in International Journal of Molecular Sciences. 2019;.
https://hdl.handle.net/21.15107/rcub_cherry_3741 .

Ciura, Krzesimir, Fedorowicz, Joanna, Andrić, Filip, Greber, Katarzyna E., Gurgielewicz, Alina, Sawicki, Wiesław, Saczewski, Jaroslaw, "Supplementary data for the article: Ciura, K.; Fedorowicz, J.; Andrić, F.; Greber, K. E.; Gurgielewicz, A.; Sawicki, W.; Saczewski, J. Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches. International Journal of Molecular Sciences 2019, 20 (21). https://doi.org/10.3390/ijms20215288" in International Journal of Molecular Sciences (2019),
https://hdl.handle.net/21.15107/rcub_cherry_3741 .