TY  - JOUR
AU  - Kojadinović, Milica I.
AU  - Arsic, Aleksandra
AU  - Petovic-Oggiano, Gordana
AU  - Gavrović-Jankulović, Marija
AU  - Glibetic, Marija
AU  - Popović, Milica M.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2551
AB  - Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Food Sciences and Nutrition
T1  - Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2
VL  - 68
IS  - 8
SP  - 952
EP  - 959
DO  - 10.1080/09637486.2017.1328665
ER  - 

@article{
author = "Kojadinović, Milica I. and Arsic, Aleksandra and Petovic-Oggiano, Gordana and Gavrović-Jankulović, Marija and Glibetic, Marija and Popović, Milica M.",
year = "2017",
abstract = "Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Food Sciences and Nutrition",
title = "Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2",
volume = "68",
number = "8",
pages = "952-959",
doi = "10.1080/09637486.2017.1328665"
}

Kojadinović, M. I., Arsic, A., Petovic-Oggiano, G., Gavrović-Jankulović, M., Glibetic, M.,& Popović, M. M.. (2017). Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. in International Journal of Food Sciences and Nutrition
Taylor & Francis Ltd, Abingdon., 68(8), 952-959.
https://doi.org/10.1080/09637486.2017.1328665

Kojadinović MI, Arsic A, Petovic-Oggiano G, Gavrović-Jankulović M, Glibetic M, Popović MM. Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. in International Journal of Food Sciences and Nutrition. 2017;68(8):952-959.
doi:10.1080/09637486.2017.1328665 .

Kojadinović, Milica I., Arsic, Aleksandra, Petovic-Oggiano, Gordana, Gavrović-Jankulović, Marija, Glibetic, Marija, Popović, Milica M., "Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2" in International Journal of Food Sciences and Nutrition, 68, no. 8 (2017):952-959,
https://doi.org/10.1080/09637486.2017.1328665 . .

TY  - JOUR
AU  - Takić, Marija M.
AU  - Ristić-Medić, Danijela
AU  - Mandić, Ljuba M.
AU  - Glibetic, Marija
AU  - Arsic, Aleksandra
AU  - Debeljak-Martacic, Jasmina
AU  - Ristic-Oddiano, Gordana
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/632
AB  - This study examines the relationship between erythrocyte phospholipid FA composition and insulin sensitivity in obese patients on a typical Serbian diet. In 30 patients, two insulin sensitivity groups were formed and their FAs analyzed. The shares of 22:5n-3, 22:6n-3, and total n-3 PUFAs, as well as a measure of Delta 5 desaturase activity (the 20:4n-6/20:3n-6 ratio) were lower in the insulin resistance group compared to the normal glucose tolerance group. The fasting insulin level and HOMA value were inversely related to the percentage of 22:5n-3, 22:6n-3, and total n-3 PUFAs. Our data indicate that the percentage of n-3 PUFAs in erythrocyte phospholipids is linked with insulin sensitivity parameters in obese patients.
AB  - Masnokiselinski sastav membrana, koji se bar delimično može modifikovati dijetarnim unosom masnih kiselina, igra važnu ulogu u senzitivnosti na insulin. Cilj ove studije bio je ispitivanje veze između senzitivnosti na insulin i masnokiselinskog sastava fosfolipida eritrocita kod gojaznih osoba. Trideset umereno gojaznih/gojaznih nedijabetičara sa hiperlipoproteinemijama (ukupni holesterol  gt  5.2 mmol/l, LDL-holesterol  gt  3.4 mmol/l) podeljeni su u dve grupe, koristeći HOMA vrednost kao parametar senzitivnosti na insulin: grupu sa normalnom tolerancom na glukozu (NTG) i grupu sa rezistencijom na insulin (IR). Ukupni lipidi eritrocita su estrahovani i fosfolipidi izolovani tankoslojnom hromatografijom. Posle metilovanja masne kiseline analizirane su gasno-tečnom hromatografijom. Zastupljenost 22:5n-3 (p  lt  0.01), 22:6n-3 (p  lt  0.01), ukupnih n-3 polinezasićenih masnih kiselina (p  lt  0.001) i odnos zastupljenosti 20:4n-6/20:3n-6 (pokazatelja aktivnosti delta-5 desaturaze) (p  lt  0.05) su sniženi u IR grupi u poređenju sa NGT grupom. Nivo insulina natašte i HOMA vrednost inverntno su povezani sa zastupljenošću 22:5n-3 (p  lt  0.05), 22:6n-3 (p  lt  0.01) i ukupnim n-3 polinezasićenim kiselinama (p  lt  0.01). Naši rezultati pokazuju da je nivo n-3 masnih kiselina u fosfolipidima eritrocita povezan sa senzitivnošću na insulin kod gojaznih osoba na ishrani tipičnoj za podneblje Srbije.
PB  - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
T2  - Archives of biological sciences
T1  - N-3 Polyunsaturated Acids in Erythrocyte Phospholipids Are Associated with Insulin Sensitivity in Obese Patients on a Typical Serbian Diet
T1  - Zastupljenost n-3 polinezasićenih masnih kiselina u fosfolipidima eritrocita i insulinska senzitivnost kod gojaznih osoba pri tipičnoj ishrani podneblja Srbije
VL  - 61
IS  - 1
SP  - 37
EP  - 43
DO  - 10.2298/ABS0901037T
ER  - 

@article{
author = "Takić, Marija M. and Ristić-Medić, Danijela and Mandić, Ljuba M. and Glibetic, Marija and Arsic, Aleksandra and Debeljak-Martacic, Jasmina and Ristic-Oddiano, Gordana",
year = "2009",
abstract = "This study examines the relationship between erythrocyte phospholipid FA composition and insulin sensitivity in obese patients on a typical Serbian diet. In 30 patients, two insulin sensitivity groups were formed and their FAs analyzed. The shares of 22:5n-3, 22:6n-3, and total n-3 PUFAs, as well as a measure of Delta 5 desaturase activity (the 20:4n-6/20:3n-6 ratio) were lower in the insulin resistance group compared to the normal glucose tolerance group. The fasting insulin level and HOMA value were inversely related to the percentage of 22:5n-3, 22:6n-3, and total n-3 PUFAs. Our data indicate that the percentage of n-3 PUFAs in erythrocyte phospholipids is linked with insulin sensitivity parameters in obese patients., Masnokiselinski sastav membrana, koji se bar delimično može modifikovati dijetarnim unosom masnih kiselina, igra važnu ulogu u senzitivnosti na insulin. Cilj ove studije bio je ispitivanje veze između senzitivnosti na insulin i masnokiselinskog sastava fosfolipida eritrocita kod gojaznih osoba. Trideset umereno gojaznih/gojaznih nedijabetičara sa hiperlipoproteinemijama (ukupni holesterol  gt  5.2 mmol/l, LDL-holesterol  gt  3.4 mmol/l) podeljeni su u dve grupe, koristeći HOMA vrednost kao parametar senzitivnosti na insulin: grupu sa normalnom tolerancom na glukozu (NTG) i grupu sa rezistencijom na insulin (IR). Ukupni lipidi eritrocita su estrahovani i fosfolipidi izolovani tankoslojnom hromatografijom. Posle metilovanja masne kiseline analizirane su gasno-tečnom hromatografijom. Zastupljenost 22:5n-3 (p  lt  0.01), 22:6n-3 (p  lt  0.01), ukupnih n-3 polinezasićenih masnih kiselina (p  lt  0.001) i odnos zastupljenosti 20:4n-6/20:3n-6 (pokazatelja aktivnosti delta-5 desaturaze) (p  lt  0.05) su sniženi u IR grupi u poređenju sa NGT grupom. Nivo insulina natašte i HOMA vrednost inverntno su povezani sa zastupljenošću 22:5n-3 (p  lt  0.05), 22:6n-3 (p  lt  0.01) i ukupnim n-3 polinezasićenim kiselinama (p  lt  0.01). Naši rezultati pokazuju da je nivo n-3 masnih kiselina u fosfolipidima eritrocita povezan sa senzitivnošću na insulin kod gojaznih osoba na ishrani tipičnoj za podneblje Srbije.",
publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd",
journal = "Archives of biological sciences",
title = "N-3 Polyunsaturated Acids in Erythrocyte Phospholipids Are Associated with Insulin Sensitivity in Obese Patients on a Typical Serbian Diet, Zastupljenost n-3 polinezasićenih masnih kiselina u fosfolipidima eritrocita i insulinska senzitivnost kod gojaznih osoba pri tipičnoj ishrani podneblja Srbije",
volume = "61",
number = "1",
pages = "37-43",
doi = "10.2298/ABS0901037T"
}

Takić, M. M., Ristić-Medić, D., Mandić, L. M., Glibetic, M., Arsic, A., Debeljak-Martacic, J.,& Ristic-Oddiano, G.. (2009). N-3 Polyunsaturated Acids in Erythrocyte Phospholipids Are Associated with Insulin Sensitivity in Obese Patients on a Typical Serbian Diet. in Archives of biological sciences
Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 61(1), 37-43.
https://doi.org/10.2298/ABS0901037T

Takić MM, Ristić-Medić D, Mandić LM, Glibetic M, Arsic A, Debeljak-Martacic J, Ristic-Oddiano G. N-3 Polyunsaturated Acids in Erythrocyte Phospholipids Are Associated with Insulin Sensitivity in Obese Patients on a Typical Serbian Diet. in Archives of biological sciences. 2009;61(1):37-43.
doi:10.2298/ABS0901037T .

Takić, Marija M., Ristić-Medić, Danijela, Mandić, Ljuba M., Glibetic, Marija, Arsic, Aleksandra, Debeljak-Martacic, Jasmina, Ristic-Oddiano, Gordana, "N-3 Polyunsaturated Acids in Erythrocyte Phospholipids Are Associated with Insulin Sensitivity in Obese Patients on a Typical Serbian Diet" in Archives of biological sciences, 61, no. 1 (2009):37-43,
https://doi.org/10.2298/ABS0901037T . .

TY  - JOUR
AU  - Nikolić, Milan
AU  - Medic, Danijela Ristic
AU  - Stanić-Vučinić, Dragana
AU  - Postic, Marija
AU  - Arsic, Aleksandra
AU  - Niketić, Vesna
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/936
AB  - Background Blood cholesterol levels are affected by diet and in particular by the type of fat intake. We originally showed that a significant but variable amount of cholesterol is firmly bound to haemoglobin (Hb) yielding the Hb-lipid adduct (Hb-Ch) in erythrocytes isolated from normo-lipidemic males. Aim of the study To establish whether dietary lipids affect the level of Hb-Ch in human erythrocytes. Methods Seventy-four healthy free-living adults were separated according to their serum cholesterol levels into two groups: normo-cholesterolemic (LDL cholesterol  lt  3.4 mmol/l and total cholesterol  lt  5.2 mmol/l) (NC) and hyper-cholesterolemic (LDL cholesterol  gt = 3.4 mmol/l) (HC). Habitual dietary information was used to classify subjects in both study groups into sub-groups of low-fat ( lt = 30% total energy as fat) and high-fat consumers ( gt  30% total energy as fat). The NC low-fat consumers were placed on a high-lipid (high-fat and high-cholesterol) diet whereas the HC subjects with high-fat intake were assigned to a low-lipid (low-fat and low-cholesterol) diet. Both types of dietary intervention were allowed to continue for 6 weeks. The main variable under scrutiny was the Hb-Ch concentration. Results In both study groups low-fat intake subjects had low levels of Hb-Ch (approx. 0.35 mmol/l RBC) compared with high-fat intake subjects (approx. 0.60 mmol/l RBC), and serum cholesterol was not correlated with Hb-Ch. The two dietary interventions produced substantial changes in the Hb-Ch level that paralleled variation in the serum cholesterol concentration. A high-lipid diet (35% fat, 15% saturated; 580 mg cholesterol) increased Hb-Ch (by approximately 47%, P  lt  0.001) in subjects with low Hb-Ch at onset, whereas a low-lipid diet (28% fat, 9% saturated; 280 mg cholesterol) decreased Hb-Ch (by approximately 40%, P  lt  0.001) in subjects with high Hb-Ch at onset. Conclusion High consumption of dietary lipids, including saturated fat and cholesterol, has an important influence on the level of Hb-Ch in human erythrocytes.
PB  - Springer Heidelberg, Heidelberg
T2  - European Journal of Nutrition
T1  - Dietary lipid intake influences the level of cholesterol bound to haemoglobin in human erythrocytes
VL  - 47
IS  - 3
SP  - 123
EP  - 130
DO  - 10.1007/s00394-008-0705-z
ER  - 

@article{
author = "Nikolić, Milan and Medic, Danijela Ristic and Stanić-Vučinić, Dragana and Postic, Marija and Arsic, Aleksandra and Niketić, Vesna",
year = "2008",
abstract = "Background Blood cholesterol levels are affected by diet and in particular by the type of fat intake. We originally showed that a significant but variable amount of cholesterol is firmly bound to haemoglobin (Hb) yielding the Hb-lipid adduct (Hb-Ch) in erythrocytes isolated from normo-lipidemic males. Aim of the study To establish whether dietary lipids affect the level of Hb-Ch in human erythrocytes. Methods Seventy-four healthy free-living adults were separated according to their serum cholesterol levels into two groups: normo-cholesterolemic (LDL cholesterol  lt  3.4 mmol/l and total cholesterol  lt  5.2 mmol/l) (NC) and hyper-cholesterolemic (LDL cholesterol  gt = 3.4 mmol/l) (HC). Habitual dietary information was used to classify subjects in both study groups into sub-groups of low-fat ( lt = 30% total energy as fat) and high-fat consumers ( gt  30% total energy as fat). The NC low-fat consumers were placed on a high-lipid (high-fat and high-cholesterol) diet whereas the HC subjects with high-fat intake were assigned to a low-lipid (low-fat and low-cholesterol) diet. Both types of dietary intervention were allowed to continue for 6 weeks. The main variable under scrutiny was the Hb-Ch concentration. Results In both study groups low-fat intake subjects had low levels of Hb-Ch (approx. 0.35 mmol/l RBC) compared with high-fat intake subjects (approx. 0.60 mmol/l RBC), and serum cholesterol was not correlated with Hb-Ch. The two dietary interventions produced substantial changes in the Hb-Ch level that paralleled variation in the serum cholesterol concentration. A high-lipid diet (35% fat, 15% saturated; 580 mg cholesterol) increased Hb-Ch (by approximately 47%, P  lt  0.001) in subjects with low Hb-Ch at onset, whereas a low-lipid diet (28% fat, 9% saturated; 280 mg cholesterol) decreased Hb-Ch (by approximately 40%, P  lt  0.001) in subjects with high Hb-Ch at onset. Conclusion High consumption of dietary lipids, including saturated fat and cholesterol, has an important influence on the level of Hb-Ch in human erythrocytes.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "European Journal of Nutrition",
title = "Dietary lipid intake influences the level of cholesterol bound to haemoglobin in human erythrocytes",
volume = "47",
number = "3",
pages = "123-130",
doi = "10.1007/s00394-008-0705-z"
}

Nikolić, M., Medic, D. R., Stanić-Vučinić, D., Postic, M., Arsic, A.,& Niketić, V.. (2008). Dietary lipid intake influences the level of cholesterol bound to haemoglobin in human erythrocytes. in European Journal of Nutrition
Springer Heidelberg, Heidelberg., 47(3), 123-130.
https://doi.org/10.1007/s00394-008-0705-z

Nikolić M, Medic DR, Stanić-Vučinić D, Postic M, Arsic A, Niketić V. Dietary lipid intake influences the level of cholesterol bound to haemoglobin in human erythrocytes. in European Journal of Nutrition. 2008;47(3):123-130.
doi:10.1007/s00394-008-0705-z .

Nikolić, Milan, Medic, Danijela Ristic, Stanić-Vučinić, Dragana, Postic, Marija, Arsic, Aleksandra, Niketić, Vesna, "Dietary lipid intake influences the level of cholesterol bound to haemoglobin in human erythrocytes" in European Journal of Nutrition, 47, no. 3 (2008):123-130,
https://doi.org/10.1007/s00394-008-0705-z . .