TY  - JOUR
AU  - Rilak, Ana
AU  - Petrović, Biljana
AU  - Grgurić-Šipka, Sanja
AU  - Tešić, Živoslav Lj.
AU  - Bugarcic, Zivadin D.
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1197
AB  - The reactions of ruthenium(II)-arene complex [Ru-II(eta(6)-p-cym)(pydc)Cl] (where p-cym = p-isopropyl toluene, pydc = 2,3-pyridinedicarboxylato) with biologically nitrogen-donor nucleophiles, such as guanosine-5'-monophosphate (5'-GMP), guanosine (Guo) and L-histidine (L-His) were studied by UV-Vis spectrophotometry and H-1 NMR spectroscopy. The reactions were studied at pH 2.5 and at 7.2. All reactions were followed under pseudo-first order conditions with large excess of the nucleophiles. The selected nucleophiles have a high affinity for Ru(II)-arene complex. The reactivity of the used ligands follow the same order at both pH values: Guo  gt  5'-GMP  gt  L-His, while the reactions at pH 7.2 are always faster. The negative entropies of activation (Delta S-not equal) support an associative mode of activation. However, the rate constants obtained by H-1 NMR at 295 K in D2O follow the same order of the ligand reactivity. The hydrolysis of the [Ru-II(eta(6)-p-cym)(pydc)Cl] complex was very fast and completed by the time the first spectrum was measured. Addition of excess of NaCl to equilibrium solutions reversed the hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands
VL  - 30
IS  - 13
SP  - 2339
EP  - 2344
DO  - 10.1016/j.poly.2011.06.019
ER  - 

@article{
author = "Rilak, Ana and Petrović, Biljana and Grgurić-Šipka, Sanja and Tešić, Živoslav Lj. and Bugarcic, Zivadin D.",
year = "2011",
abstract = "The reactions of ruthenium(II)-arene complex [Ru-II(eta(6)-p-cym)(pydc)Cl] (where p-cym = p-isopropyl toluene, pydc = 2,3-pyridinedicarboxylato) with biologically nitrogen-donor nucleophiles, such as guanosine-5'-monophosphate (5'-GMP), guanosine (Guo) and L-histidine (L-His) were studied by UV-Vis spectrophotometry and H-1 NMR spectroscopy. The reactions were studied at pH 2.5 and at 7.2. All reactions were followed under pseudo-first order conditions with large excess of the nucleophiles. The selected nucleophiles have a high affinity for Ru(II)-arene complex. The reactivity of the used ligands follow the same order at both pH values: Guo  gt  5'-GMP  gt  L-His, while the reactions at pH 7.2 are always faster. The negative entropies of activation (Delta S-not equal) support an associative mode of activation. However, the rate constants obtained by H-1 NMR at 295 K in D2O follow the same order of the ligand reactivity. The hydrolysis of the [Ru-II(eta(6)-p-cym)(pydc)Cl] complex was very fast and completed by the time the first spectrum was measured. Addition of excess of NaCl to equilibrium solutions reversed the hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands",
volume = "30",
number = "13",
pages = "2339-2344",
doi = "10.1016/j.poly.2011.06.019"
}

Rilak, A., Petrović, B., Grgurić-Šipka, S., Tešić, Ž. Lj.,& Bugarcic, Z. D.. (2011). Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 30(13), 2339-2344.
https://doi.org/10.1016/j.poly.2011.06.019

Rilak A, Petrović B, Grgurić-Šipka S, Tešić ŽL, Bugarcic ZD. Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands. in Polyhedron. 2011;30(13):2339-2344.
doi:10.1016/j.poly.2011.06.019 .

Rilak, Ana, Petrović, Biljana, Grgurić-Šipka, Sanja, Tešić, Živoslav Lj., Bugarcic, Zivadin D., "Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands" in Polyhedron, 30, no. 13 (2011):2339-2344,
https://doi.org/10.1016/j.poly.2011.06.019 . .