TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - n/a
IS  - n/a
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 

@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "n/a",
number = "n/a",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}

Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R..Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., n/a(n/a), e2300426.
https://doi.org/10.1002/ardp.202300426

Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov J, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie.n/a(n/a):e2300426.
doi:10.1002/ardp.202300426 .

Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana, Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, n/a, no. n/a:e2300426,
https://doi.org/10.1002/ardp.202300426 . .

TY  - CONF
AU  - Živanović, Marija
AU  - Selaković, Milica
AU  - Selaković, Života
AU  - Pavić, Aleksandar
AU  - Grahovac, Jelena
AU  - Šolaja, Bogdan A.
AU  - Srdić-Rajić, Tatjana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5695
PB  - Elsevier
C3  - European Journal of Cancer
T1  - 322 (PB102) - Cationic amphiphilic drugs as potential anticancer therapy for PDAC
VL  - 174S1
IS  - PB102
SP  - S114
DO  - 10.1016/S0959-8049(22)01106-6
ER  - 

@conference{
author = "Živanović, Marija and Selaković, Milica and Selaković, Života and Pavić, Aleksandar and Grahovac, Jelena and Šolaja, Bogdan A. and Srdić-Rajić, Tatjana",
year = "2022",
publisher = "Elsevier",
journal = "European Journal of Cancer",
title = "322 (PB102) - Cationic amphiphilic drugs as potential anticancer therapy for PDAC",
volume = "174S1",
number = "PB102",
pages = "S114",
doi = "10.1016/S0959-8049(22)01106-6"
}

Živanović, M., Selaković, M., Selaković, Ž., Pavić, A., Grahovac, J., Šolaja, B. A.,& Srdić-Rajić, T.. (2022). 322 (PB102) - Cationic amphiphilic drugs as potential anticancer therapy for PDAC. in European Journal of Cancer
Elsevier., 174S1(PB102), S114.
https://doi.org/10.1016/S0959-8049(22)01106-6

Živanović M, Selaković M, Selaković Ž, Pavić A, Grahovac J, Šolaja BA, Srdić-Rajić T. 322 (PB102) - Cationic amphiphilic drugs as potential anticancer therapy for PDAC. in European Journal of Cancer. 2022;174S1(PB102):S114.
doi:10.1016/S0959-8049(22)01106-6 .

Živanović, Marija, Selaković, Milica, Selaković, Života, Pavić, Aleksandar, Grahovac, Jelena, Šolaja, Bogdan A., Srdić-Rajić, Tatjana, "322 (PB102) - Cationic amphiphilic drugs as potential anticancer therapy for PDAC" in European Journal of Cancer, 174S1, no. PB102 (2022):S114,
https://doi.org/10.1016/S0959-8049(22)01106-6 . .

TY  - JOUR
AU  - Videnović, Milica
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Opsenica, Igor
AU  - Srdić-Rajić, Tatjana
AU  - Šolaja, Bogdan A.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2233
AB  - A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Benzothiazole carbamates and amides as antiproliferative species
VL  - 157
SP  - 1096
EP  - 1114
DO  - 10.1016/j.ejmech.2018.08.067
ER  - 

@article{
author = "Videnović, Milica and Mojsin, Marija and Stevanović, Milena and Opsenica, Igor and Srdić-Rajić, Tatjana and Šolaja, Bogdan A.",
year = "2018",
abstract = "A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Benzothiazole carbamates and amides as antiproliferative species",
volume = "157",
pages = "1096-1114",
doi = "10.1016/j.ejmech.2018.08.067"
}

Videnović, M., Mojsin, M., Stevanović, M., Opsenica, I., Srdić-Rajić, T.,& Šolaja, B. A.. (2018). Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 157, 1096-1114.
https://doi.org/10.1016/j.ejmech.2018.08.067

Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja BA. Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry. 2018;157:1096-1114.
doi:10.1016/j.ejmech.2018.08.067 .

Videnović, Milica, Mojsin, Marija, Stevanović, Milena, Opsenica, Igor, Srdić-Rajić, Tatjana, Šolaja, Bogdan A., "Benzothiazole carbamates and amides as antiproliferative species" in European Journal of Medicinal Chemistry, 157 (2018):1096-1114,
https://doi.org/10.1016/j.ejmech.2018.08.067 . .

TY  - JOUR
AU  - Videnović, Milica
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Opsenica, Igor
AU  - Srdić-Rajić, Tatjana
AU  - Šolaja, Bogdan A.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2960
AB  - A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Benzothiazole carbamates and amides as antiproliferative species
VL  - 157
SP  - 1096
EP  - 1114
DO  - 10.1016/j.ejmech.2018.08.067
ER  - 

@article{
author = "Videnović, Milica and Mojsin, Marija and Stevanović, Milena and Opsenica, Igor and Srdić-Rajić, Tatjana and Šolaja, Bogdan A.",
year = "2018",
abstract = "A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Benzothiazole carbamates and amides as antiproliferative species",
volume = "157",
pages = "1096-1114",
doi = "10.1016/j.ejmech.2018.08.067"
}

Videnović, M., Mojsin, M., Stevanović, M., Opsenica, I., Srdić-Rajić, T.,& Šolaja, B. A.. (2018). Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 157, 1096-1114.
https://doi.org/10.1016/j.ejmech.2018.08.067

Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja BA. Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry. 2018;157:1096-1114.
doi:10.1016/j.ejmech.2018.08.067 .

Videnović, Milica, Mojsin, Marija, Stevanović, Milena, Opsenica, Igor, Srdić-Rajić, Tatjana, Šolaja, Bogdan A., "Benzothiazole carbamates and amides as antiproliferative species" in European Journal of Medicinal Chemistry, 157 (2018):1096-1114,
https://doi.org/10.1016/j.ejmech.2018.08.067 . .

TY  - DATA
AU  - Videnović, Milica
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Opsenica, Igor
AU  - Srdić-Rajić, Tatjana
AU  - Šolaja, Bogdan A.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2961
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Supplementary material for the article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. https://doi.org/10.1016/j.ejmech.2018.08.067
VL  - 157
SP  - 1096
EP  - 1114
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2961
ER  - 

@misc{
author = "Videnović, Milica and Mojsin, Marija and Stevanović, Milena and Opsenica, Igor and Srdić-Rajić, Tatjana and Šolaja, Bogdan A.",
year = "2018",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Supplementary material for the article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. https://doi.org/10.1016/j.ejmech.2018.08.067",
volume = "157",
pages = "1096-1114",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2961"
}

Videnović, M., Mojsin, M., Stevanović, M., Opsenica, I., Srdić-Rajić, T.,& Šolaja, B. A.. (2018). Supplementary material for the article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. https://doi.org/10.1016/j.ejmech.2018.08.067. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 157, 1096-1114.
https://hdl.handle.net/21.15107/rcub_cherry_2961

Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja BA. Supplementary material for the article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. https://doi.org/10.1016/j.ejmech.2018.08.067. in European Journal of Medicinal Chemistry. 2018;157:1096-1114.
https://hdl.handle.net/21.15107/rcub_cherry_2961 .

Videnović, Milica, Mojsin, Marija, Stevanović, Milena, Opsenica, Igor, Srdić-Rajić, Tatjana, Šolaja, Bogdan A., "Supplementary material for the article: Videnović, M.; Mojsin, M.; Stevanović, M.; Opsenica, I.; Srdić-Rajić, T.; Šolaja, B. Benzothiazole Carbamates and Amides as Antiproliferative Species. Eur. J. Med. Chem. 2018, 157, 1096–1114. https://doi.org/10.1016/j.ejmech.2018.08.067" in European Journal of Medicinal Chemistry, 157 (2018):1096-1114,
https://hdl.handle.net/21.15107/rcub_cherry_2961 .

TY  - CONF
AU  - Videnović, Milica
AU  - Mojsin, Marija
AU  - Srdić-Rajić, Tatjana
AU  - Opsenica, Igor
AU  - Stevanović, Milena
AU  - Šolaja, Bogdan A.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5348
C3  - 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8. i 9. jun 2018.
T1  - Potencijalno antimetastatsko i antiproliferativno dejstvo derivata benzotiazola na ćelije embrionalnog humanog teratokarcinoma NT2/D1
T1  - Potential antimetastatic and antiproliferative activity of benzothiazole derivatives against NT2/D1 embryonal human teratocarcinoma cell line
VL  - 87
EP  - 87
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5348
ER  - 

@conference{
author = "Videnović, Milica and Mojsin, Marija and Srdić-Rajić, Tatjana and Opsenica, Igor and Stevanović, Milena and Šolaja, Bogdan A.",
year = "2018",
journal = "55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8. i 9. jun 2018.",
title = "Potencijalno antimetastatsko i antiproliferativno dejstvo derivata benzotiazola na ćelije embrionalnog humanog teratokarcinoma NT2/D1, Potential antimetastatic and antiproliferative activity of benzothiazole derivatives against NT2/D1 embryonal human teratocarcinoma cell line",
volume = "87",
pages = "87",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5348"
}

Videnović, M., Mojsin, M., Srdić-Rajić, T., Opsenica, I., Stevanović, M.,& Šolaja, B. A.. (2018). Potencijalno antimetastatsko i antiproliferativno dejstvo derivata benzotiazola na ćelije embrionalnog humanog teratokarcinoma NT2/D1. in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8. i 9. jun 2018., 87.
https://hdl.handle.net/21.15107/rcub_cherry_5348

Videnović M, Mojsin M, Srdić-Rajić T, Opsenica I, Stevanović M, Šolaja BA. Potencijalno antimetastatsko i antiproliferativno dejstvo derivata benzotiazola na ćelije embrionalnog humanog teratokarcinoma NT2/D1. in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8. i 9. jun 2018.. 2018;87:null-87.
https://hdl.handle.net/21.15107/rcub_cherry_5348 .

Videnović, Milica, Mojsin, Marija, Srdić-Rajić, Tatjana, Opsenica, Igor, Stevanović, Milena, Šolaja, Bogdan A., "Potencijalno antimetastatsko i antiproliferativno dejstvo derivata benzotiazola na ćelije embrionalnog humanog teratokarcinoma NT2/D1" in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8. i 9. jun 2018., 87 (2018),
https://hdl.handle.net/21.15107/rcub_cherry_5348 .

TY  - CONF
AU  - Videnović, Milica
AU  - Srdić-Rajić, Tatjana
AU  - Opsenica, Igor
AU  - Radulović, Siniša
AU  - Šolaja, Bogdan A.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5347
AB  - Poznato je da se mnogi lekovi, derivati benzotiazola, vrlo uspešno koriste u tretmanu
različitih kliničkih stanja.1
 Takođe, značajno mesto zauzimaju u istraživanjima
antitumorskih agenasa i veliki broj strukturnih modifikacija jezgra benzotiazola načinjen je
s ciljem poboljšanja njihove antitumorske aktivnosti. U okviru naših istraživanja u ovoj
oblasti sintetisana je serija novih karbamata i amida 6-alkiltio-supstituisanih
benzotiazolamina i ispitana je njihova antiproliferativna aktivnost prema MCF-7 ćelijskoj
liniji humanog karcinoma dojke. Pokazano je da derivati benzotiazolamina izazivaju visoko
specifičnu programiranu ćelijsku smrt apoptozu u značajnom procentu tretiranih MCF-7
ćelija. Ispitan je i uticaj novih jedinjenja na ćelijski ciklus, mitohondrijski membranski
potencijal i nivo unutarćelijskih reaktivnih kiseoničnih vrsta
AB  - Numerous benzothiazole-based clinical drugs have been extensively used in practice to
treat various type of diseases with high therapeutic efficacy.1
 In addition, benzothiazole derivatives are compounds of an undoubted interest in anticancer research and a lot of structural modifications on their core nuclei have been made to improve their antitumor activety. Therefore, we have synthesized a series of novel 6-alkylthio-substituted benzothiazolamine carbamates and amides. To investigate their anticancer potency, we have used MCF7 human breast cancer cell line. Benzothiazolamine derivatives show great potency for
promoting highly specific programmed cell death apoptosis in MCF-7 cancer cell line. Our
research continued towards examination of our compounds influence on cell cycle phase
distribution, reactive oxygen species level and mitochondrial membrane potential.
C3  - 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016.
T1  - Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke
T1  - Investigation of antiproliferative activity of new benzothiazolamine derivatives against MCF-7 human breast cancer cell line
SP  - 99
EP  - 99
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5347
ER  - 

@conference{
author = "Videnović, Milica and Srdić-Rajić, Tatjana and Opsenica, Igor and Radulović, Siniša and Šolaja, Bogdan A.",
year = "2016",
abstract = "Poznato je da se mnogi lekovi, derivati benzotiazola, vrlo uspešno koriste u tretmanu
različitih kliničkih stanja.1
 Takođe, značajno mesto zauzimaju u istraživanjima
antitumorskih agenasa i veliki broj strukturnih modifikacija jezgra benzotiazola načinjen je
s ciljem poboljšanja njihove antitumorske aktivnosti. U okviru naših istraživanja u ovoj
oblasti sintetisana je serija novih karbamata i amida 6-alkiltio-supstituisanih
benzotiazolamina i ispitana je njihova antiproliferativna aktivnost prema MCF-7 ćelijskoj
liniji humanog karcinoma dojke. Pokazano je da derivati benzotiazolamina izazivaju visoko
specifičnu programiranu ćelijsku smrt apoptozu u značajnom procentu tretiranih MCF-7
ćelija. Ispitan je i uticaj novih jedinjenja na ćelijski ciklus, mitohondrijski membranski
potencijal i nivo unutarćelijskih reaktivnih kiseoničnih vrsta, Numerous benzothiazole-based clinical drugs have been extensively used in practice to
treat various type of diseases with high therapeutic efficacy.1
 In addition, benzothiazole derivatives are compounds of an undoubted interest in anticancer research and a lot of structural modifications on their core nuclei have been made to improve their antitumor activety. Therefore, we have synthesized a series of novel 6-alkylthio-substituted benzothiazolamine carbamates and amides. To investigate their anticancer potency, we have used MCF7 human breast cancer cell line. Benzothiazolamine derivatives show great potency for
promoting highly specific programmed cell death apoptosis in MCF-7 cancer cell line. Our
research continued towards examination of our compounds influence on cell cycle phase
distribution, reactive oxygen species level and mitochondrial membrane potential.",
journal = "53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016.",
title = "Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke, Investigation of antiproliferative activity of new benzothiazolamine derivatives against MCF-7 human breast cancer cell line",
pages = "99-99",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5347"
}

Videnović, M., Srdić-Rajić, T., Opsenica, I., Radulović, S.,& Šolaja, B. A.. (2016). Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke. in 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016., 99-99.
https://hdl.handle.net/21.15107/rcub_cherry_5347

Videnović M, Srdić-Rajić T, Opsenica I, Radulović S, Šolaja BA. Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke. in 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016.. 2016;:99-99.
https://hdl.handle.net/21.15107/rcub_cherry_5347 .

Videnović, Milica, Srdić-Rajić, Tatjana, Opsenica, Igor, Radulović, Siniša, Šolaja, Bogdan A., "Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke" in 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016. (2016):99-99,
https://hdl.handle.net/21.15107/rcub_cherry_5347 .

TY  - CONF
AU  - Videnović, Milica
AU  - Srdić-Rajić, Tatjana
AU  - Opsenica, Igor
AU  - Radulović, Siniša
AU  - Šolaja, Bogdan A.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5349
AB  - Background
Cancer is the second leading cause of morbidity and mortality worldwide, with approximately 14 million
new cases and 8.2 million cancer-related deaths in 2012.1
 Current chemotherapy targets the proliferative
advantage of tumor cells over healthy cells, but the lack of selectivity of chemotherapeutic agents usually
leads to serious side effects. A major challenge in the development of effective and safe cancer treatment
is to identify the agents that could affect cellular processes essential for, or greatly enhanced in, malignant
cells only.
Aims
Benzothiazole derivatives represent a series of compounds of an undoubted interest because of the broad
spectrum of biological effects associated with this scaffold.2
 In addition, benzothiazoles have attracted
considerable attention in anticancer research and a lot of structural modifications on their core nuclei have
been made to improve the antitumor activity. Therefore, we have synthesized novel benzothiazolamine
derivatives and investigated their anticancer potential against MCF-7 human breast cancer cell line.
Methods
We have synthesized a series of novel benzothiazolamine carbamates and amides starting from 1-chloro4-nitrobenzene and an appropriate alkylthiol, 3 followed by cyclization to benzothiazolamine and further
derivatization of amino-group. The selected compounds were subjected to a panel of NCI-60 cell line for
in vitro determination of antitumor activity. For better insight into possible mechanism of antiproliferative
activity, we have examined the cell cycle phase distribution and apoptosis in MCF-7 human breast cancer
cell line using flow cytometry methods, after treatment with synthesized compounds. Our research
continued towards examination of our compounds’ influence on the reactive oxygen species level,
mitochondrial membrane potential, as well as cell cycle regulators.
Results
The cell cycle phase distribution and apoptosis in MCF-7 human breast cancer cell line were investigated
after exposure to IC50 concentrations, obtained in vitro, of four selected compounds (Figure 1.b) for 24
and 48 hours, respectively. Using flow cytometry after PI staining we showed that our compounds affect cell cycle distribution in a
time dependent manner. After 24 h treatment, the portion of cells in G2/M phase increased, suggesting
cell cycle arrest in mitosis. After 48 hours, the number of sub G1 phase cells increased, which indicates
apoptosis.
Following incubation with selected compounds for 48 hours, the proapoptotic effect was reflected by the
increase of portion of early apoptotic cells up to 63 % measured by bivariate Annexin V/PI flow
cytometry (Figure 1.a). Moreover, we observed the loss of mitochondrial membrane potential, which
could indicate that our compounds promote apoptosis via the mitochondrial pathway in MCF-7 cells. In
addition, reactive oxygen species level in MCF-7 cells significantly decreased after treatment with
benzothiazolamine derivatives.
Conclusion
Benzothiazolamine carbamates and amides showed great potency for promoting highly specific
programmed cell death apoptosis in MCF-7 cancer cell line. Further examination will eventually provide
identification of molecular targets of benzothiazolamines. Our data offer a significant contribution to the
search for medicinally active compounds and may lead to discovery of a new potent antitumor agent.
C3  - European School of Medicinal Chemistry (XXXVI Advanced Course of Medicinal Chemistry and "E. Duranti" National Seminar for PhD Students) Proceedings of PhD student poster session
T1  - New benzothiazolamine derivatives as inducers of an early apoptosis in MCF-7 human breast cancer cell line
SP  - 75
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5349
ER  - 

@conference{
author = "Videnović, Milica and Srdić-Rajić, Tatjana and Opsenica, Igor and Radulović, Siniša and Šolaja, Bogdan A.",
year = "2016",
abstract = "Background
Cancer is the second leading cause of morbidity and mortality worldwide, with approximately 14 million
new cases and 8.2 million cancer-related deaths in 2012.1
 Current chemotherapy targets the proliferative
advantage of tumor cells over healthy cells, but the lack of selectivity of chemotherapeutic agents usually
leads to serious side effects. A major challenge in the development of effective and safe cancer treatment
is to identify the agents that could affect cellular processes essential for, or greatly enhanced in, malignant
cells only.
Aims
Benzothiazole derivatives represent a series of compounds of an undoubted interest because of the broad
spectrum of biological effects associated with this scaffold.2
 In addition, benzothiazoles have attracted
considerable attention in anticancer research and a lot of structural modifications on their core nuclei have
been made to improve the antitumor activity. Therefore, we have synthesized novel benzothiazolamine
derivatives and investigated their anticancer potential against MCF-7 human breast cancer cell line.
Methods
We have synthesized a series of novel benzothiazolamine carbamates and amides starting from 1-chloro4-nitrobenzene and an appropriate alkylthiol, 3 followed by cyclization to benzothiazolamine and further
derivatization of amino-group. The selected compounds were subjected to a panel of NCI-60 cell line for
in vitro determination of antitumor activity. For better insight into possible mechanism of antiproliferative
activity, we have examined the cell cycle phase distribution and apoptosis in MCF-7 human breast cancer
cell line using flow cytometry methods, after treatment with synthesized compounds. Our research
continued towards examination of our compounds’ influence on the reactive oxygen species level,
mitochondrial membrane potential, as well as cell cycle regulators.
Results
The cell cycle phase distribution and apoptosis in MCF-7 human breast cancer cell line were investigated
after exposure to IC50 concentrations, obtained in vitro, of four selected compounds (Figure 1.b) for 24
and 48 hours, respectively. Using flow cytometry after PI staining we showed that our compounds affect cell cycle distribution in a
time dependent manner. After 24 h treatment, the portion of cells in G2/M phase increased, suggesting
cell cycle arrest in mitosis. After 48 hours, the number of sub G1 phase cells increased, which indicates
apoptosis.
Following incubation with selected compounds for 48 hours, the proapoptotic effect was reflected by the
increase of portion of early apoptotic cells up to 63 % measured by bivariate Annexin V/PI flow
cytometry (Figure 1.a). Moreover, we observed the loss of mitochondrial membrane potential, which
could indicate that our compounds promote apoptosis via the mitochondrial pathway in MCF-7 cells. In
addition, reactive oxygen species level in MCF-7 cells significantly decreased after treatment with
benzothiazolamine derivatives.
Conclusion
Benzothiazolamine carbamates and amides showed great potency for promoting highly specific
programmed cell death apoptosis in MCF-7 cancer cell line. Further examination will eventually provide
identification of molecular targets of benzothiazolamines. Our data offer a significant contribution to the
search for medicinally active compounds and may lead to discovery of a new potent antitumor agent.",
journal = "European School of Medicinal Chemistry (XXXVI Advanced Course of Medicinal Chemistry and "E. Duranti" National Seminar for PhD Students) Proceedings of PhD student poster session",
title = "New benzothiazolamine derivatives as inducers of an early apoptosis in MCF-7 human breast cancer cell line",
pages = "75-76",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5349"
}

Videnović, M., Srdić-Rajić, T., Opsenica, I., Radulović, S.,& Šolaja, B. A.. (2016). New benzothiazolamine derivatives as inducers of an early apoptosis in MCF-7 human breast cancer cell line. in European School of Medicinal Chemistry (XXXVI Advanced Course of Medicinal Chemistry and "E. Duranti" National Seminar for PhD Students) Proceedings of PhD student poster session, 75-76.
https://hdl.handle.net/21.15107/rcub_cherry_5349

Videnović M, Srdić-Rajić T, Opsenica I, Radulović S, Šolaja BA. New benzothiazolamine derivatives as inducers of an early apoptosis in MCF-7 human breast cancer cell line. in European School of Medicinal Chemistry (XXXVI Advanced Course of Medicinal Chemistry and "E. Duranti" National Seminar for PhD Students) Proceedings of PhD student poster session. 2016;:75-76.
https://hdl.handle.net/21.15107/rcub_cherry_5349 .

Videnović, Milica, Srdić-Rajić, Tatjana, Opsenica, Igor, Radulović, Siniša, Šolaja, Bogdan A., "New benzothiazolamine derivatives as inducers of an early apoptosis in MCF-7 human breast cancer cell line" in European School of Medicinal Chemistry (XXXVI Advanced Course of Medicinal Chemistry and "E. Duranti" National Seminar for PhD Students) Proceedings of PhD student poster session (2016):75-76,
https://hdl.handle.net/21.15107/rcub_cherry_5349 .

TY  - JOUR
AU  - Zec, Manja
AU  - Srdić-Rajić, Tatjana
AU  - Krivokuca, Ana
AU  - Jankovic, Radmila
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Radulović, Siniša
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1877
AB  - The synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes of Zn(II), Cd(II) and Ni(II) were published previously. Here we report first evidence on anti-proliferative activity of the complexes and molecular patterns that underlie it. The complexes and the corresponding ligand are shown to be cytotoxic on the panel of nine, malignant and non-malignant cell lines, with the exception of Ni(II) complex that did not achieve IC50 value on any of the cell lines tested. Further experiments on the selected cell lines including A 549, MRC-5, EA.hy 926 and HeLa, have shown that the complexes posses unambiguous property of inducing necrosis in the cells treated for 6 hours, with the ligand and Zn(II) complex being the most active on all cell lines. On the contrary, only small portion of early apoptotic events was detected, under the same experimental condition. This was in complete concordance with the results obtained from Western blot analysis of the treated cells that showed no or slight increase of the protein amounts of two crucial apoptotic mediators: Cytochrome C and Caspase III. We propose the model, under which tested complexes induce necroptosis in treated cells, a recently described type of cell death with necrotic morphological features and acting via caspase independent pathway, and without elevated amounts of intracellular ROS. Endothelial EA.hy 926 cells have proven to be extremely sensitive on the necrosis-inducing effect of the complexes, which could indicate potential anti-angiogenic effect of the novel complexes that is to be investigated.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Medicinal Chemistry
T1  - Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death
VL  - 10
IS  - 8
SP  - 759
EP  - 771
DO  - 10.2174/1573406410666140327122009
ER  - 

@article{
author = "Zec, Manja and Srdić-Rajić, Tatjana and Krivokuca, Ana and Jankovic, Radmila and Todorović, Tamara and Anđelković, Katarina K. and Radulović, Siniša",
year = "2014",
abstract = "The synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes of Zn(II), Cd(II) and Ni(II) were published previously. Here we report first evidence on anti-proliferative activity of the complexes and molecular patterns that underlie it. The complexes and the corresponding ligand are shown to be cytotoxic on the panel of nine, malignant and non-malignant cell lines, with the exception of Ni(II) complex that did not achieve IC50 value on any of the cell lines tested. Further experiments on the selected cell lines including A 549, MRC-5, EA.hy 926 and HeLa, have shown that the complexes posses unambiguous property of inducing necrosis in the cells treated for 6 hours, with the ligand and Zn(II) complex being the most active on all cell lines. On the contrary, only small portion of early apoptotic events was detected, under the same experimental condition. This was in complete concordance with the results obtained from Western blot analysis of the treated cells that showed no or slight increase of the protein amounts of two crucial apoptotic mediators: Cytochrome C and Caspase III. We propose the model, under which tested complexes induce necroptosis in treated cells, a recently described type of cell death with necrotic morphological features and acting via caspase independent pathway, and without elevated amounts of intracellular ROS. Endothelial EA.hy 926 cells have proven to be extremely sensitive on the necrosis-inducing effect of the complexes, which could indicate potential anti-angiogenic effect of the novel complexes that is to be investigated.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Medicinal Chemistry",
title = "Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death",
volume = "10",
number = "8",
pages = "759-771",
doi = "10.2174/1573406410666140327122009"
}

Zec, M., Srdić-Rajić, T., Krivokuca, A., Jankovic, R., Todorović, T., Anđelković, K. K.,& Radulović, S.. (2014). Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death. in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 10(8), 759-771.
https://doi.org/10.2174/1573406410666140327122009

Zec M, Srdić-Rajić T, Krivokuca A, Jankovic R, Todorović T, Anđelković KK, Radulović S. Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death. in Medicinal Chemistry. 2014;10(8):759-771.
doi:10.2174/1573406410666140327122009 .

Zec, Manja, Srdić-Rajić, Tatjana, Krivokuca, Ana, Jankovic, Radmila, Todorović, Tamara, Anđelković, Katarina K., Radulović, Siniša, "Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death" in Medicinal Chemistry, 10, no. 8 (2014):759-771,
https://doi.org/10.2174/1573406410666140327122009 . .

TY  - JOUR
AU  - Filipović, Lana
AU  - Aranđelović, Sandra
AU  - Gligorijević, Nevenka
AU  - Krivokuca, Ana
AU  - Jankovic, Radmila
AU  - Srdić-Rajić, Tatjana
AU  - Rakic, Gordana
AU  - Tešić, Živoslav Lj.
AU  - Radulović, Siniša
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1414
AB  - Background. In our previous study we reported the synthesis and cytotoxicity of two trans-platinum(II) complexes: trans-[PtCl2(3-acetylpyridine)(2)] (1) and trans-[PtCl2(4-acetylpyridine)(2)] (2), revealing significant cytotoxic potential of 2. In order to evaluate the mechanism underlying biological activity of both trans-Pt(II) isomers, comparative studies versus cisplatin were performed in HeLa, MRC-5 and MS1 cells. Materials and methods. The cytotoxic activity of the investigated complexes was determined using SRB assay. The colagenolytic activity was determined using gelatin zymography, while the effect of platinum complexes on matrix metalloproteinases 2 and 9 mRNA expression was evaluated by quantitative real-time PCR. Apoptotic potential and cell cycle alterations were determined by FACS analyses. Western blot analysis was used to evaluate the effect on expression of DNA-repair enzyme ERCC1, and quantitative real-time PCR was used for the ERCC1 mRNA expression analysis. In vitro antiangiogenic potential was determined by tube formation assay. Platinum content in intracellular DNA and proteins was determined by inductively coupled plasma-optical emission spectrometry. Results. Compound 2 displayed an apparent cytoselective profile, and flow cytometry analysis in HeLa cells indicated that 2 exerted antiproliferative effect through apoptosis induction, while 1 induced both apoptosis and necrosis. Action of 1 and 2, as analyzed by quantitative real-time PCR and Western blot, was associated with down-regulation of ERCC1. Both trans-complexes inhibited MMP-9 mRNA expression in HeLa, while 2 significantly abrogated in vitro tubulogenesis in MS1 cells. Conclusions. The ability of 2 to induce multiple and selective in vitro cytotoxic effects encourages further investigations of trans-platinum(II) complexes with substituted pyridines.
PB  - Assoc Radiology & Oncology, Ljubljana
T2  - Radiology and Oncology
T1  - Biological evaluation of transdichloridoplatinum( II) complexes with 3-and 4-acetylpyridine in comparison to cisplatin
VL  - 47
IS  - 4
SP  - 346
EP  - 357
DO  - 10.2478/raon-2013-0050
ER  - 

@article{
author = "Filipović, Lana and Aranđelović, Sandra and Gligorijević, Nevenka and Krivokuca, Ana and Jankovic, Radmila and Srdić-Rajić, Tatjana and Rakic, Gordana and Tešić, Živoslav Lj. and Radulović, Siniša",
year = "2013",
abstract = "Background. In our previous study we reported the synthesis and cytotoxicity of two trans-platinum(II) complexes: trans-[PtCl2(3-acetylpyridine)(2)] (1) and trans-[PtCl2(4-acetylpyridine)(2)] (2), revealing significant cytotoxic potential of 2. In order to evaluate the mechanism underlying biological activity of both trans-Pt(II) isomers, comparative studies versus cisplatin were performed in HeLa, MRC-5 and MS1 cells. Materials and methods. The cytotoxic activity of the investigated complexes was determined using SRB assay. The colagenolytic activity was determined using gelatin zymography, while the effect of platinum complexes on matrix metalloproteinases 2 and 9 mRNA expression was evaluated by quantitative real-time PCR. Apoptotic potential and cell cycle alterations were determined by FACS analyses. Western blot analysis was used to evaluate the effect on expression of DNA-repair enzyme ERCC1, and quantitative real-time PCR was used for the ERCC1 mRNA expression analysis. In vitro antiangiogenic potential was determined by tube formation assay. Platinum content in intracellular DNA and proteins was determined by inductively coupled plasma-optical emission spectrometry. Results. Compound 2 displayed an apparent cytoselective profile, and flow cytometry analysis in HeLa cells indicated that 2 exerted antiproliferative effect through apoptosis induction, while 1 induced both apoptosis and necrosis. Action of 1 and 2, as analyzed by quantitative real-time PCR and Western blot, was associated with down-regulation of ERCC1. Both trans-complexes inhibited MMP-9 mRNA expression in HeLa, while 2 significantly abrogated in vitro tubulogenesis in MS1 cells. Conclusions. The ability of 2 to induce multiple and selective in vitro cytotoxic effects encourages further investigations of trans-platinum(II) complexes with substituted pyridines.",
publisher = "Assoc Radiology & Oncology, Ljubljana",
journal = "Radiology and Oncology",
title = "Biological evaluation of transdichloridoplatinum( II) complexes with 3-and 4-acetylpyridine in comparison to cisplatin",
volume = "47",
number = "4",
pages = "346-357",
doi = "10.2478/raon-2013-0050"
}

Filipović, L., Aranđelović, S., Gligorijević, N., Krivokuca, A., Jankovic, R., Srdić-Rajić, T., Rakic, G., Tešić, Ž. Lj.,& Radulović, S.. (2013). Biological evaluation of transdichloridoplatinum( II) complexes with 3-and 4-acetylpyridine in comparison to cisplatin. in Radiology and Oncology
Assoc Radiology & Oncology, Ljubljana., 47(4), 346-357.
https://doi.org/10.2478/raon-2013-0050

Filipović L, Aranđelović S, Gligorijević N, Krivokuca A, Jankovic R, Srdić-Rajić T, Rakic G, Tešić ŽL, Radulović S. Biological evaluation of transdichloridoplatinum( II) complexes with 3-and 4-acetylpyridine in comparison to cisplatin. in Radiology and Oncology. 2013;47(4):346-357.
doi:10.2478/raon-2013-0050 .

Filipović, Lana, Aranđelović, Sandra, Gligorijević, Nevenka, Krivokuca, Ana, Jankovic, Radmila, Srdić-Rajić, Tatjana, Rakic, Gordana, Tešić, Živoslav Lj., Radulović, Siniša, "Biological evaluation of transdichloridoplatinum( II) complexes with 3-and 4-acetylpyridine in comparison to cisplatin" in Radiology and Oncology, 47, no. 4 (2013):346-357,
https://doi.org/10.2478/raon-2013-0050 . .

TY  - JOUR
AU  - Čavić, Milena
AU  - Grozdanović, Milica
AU  - Bajić, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Andjus, Pavle R.
AU  - Gavrović-Jankulović, Marija
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1284
AB  - Actinidin belongs to the papain-like family of cysteine proteases and is a major kiwifruit allergen. In this study, the effect of actinidin on cellular morphology and adhesion of T84 intestinal cells was investigated. Both rounding and detachment of T84 cells were observed upon actinidin treatment. The morphological changes and cell desquamation was protease-dependent, as well as time- and concentration-dependent. Changes of intercellular adhesion and adhesion of epithelial cells to collagen upon actinidin treatment could be responsible for the cell rounding and give rise to discontinuous breaches in the epithelial monolayer observed in this study. Actinidin's action on cell morphology, adhesion and monolayer integrity were not due to compromised viability of T84 epithelial cells, as confirmed by MTT assay and flow cytometric analysis of the cell cycle. Damage to the epithelial monolayer of the intestine induced by actinidin should be further evaluated as an important factor in the development of kiwifruit allergy and other intestinal disorders.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells
VL  - 77
SP  - 46
EP  - 52
DO  - 10.1016/j.phytochem.2011.12.014
ER  - 

@article{
author = "Čavić, Milena and Grozdanović, Milica and Bajić, Aleksandar and Srdić-Rajić, Tatjana and Andjus, Pavle R. and Gavrović-Jankulović, Marija",
year = "2012",
abstract = "Actinidin belongs to the papain-like family of cysteine proteases and is a major kiwifruit allergen. In this study, the effect of actinidin on cellular morphology and adhesion of T84 intestinal cells was investigated. Both rounding and detachment of T84 cells were observed upon actinidin treatment. The morphological changes and cell desquamation was protease-dependent, as well as time- and concentration-dependent. Changes of intercellular adhesion and adhesion of epithelial cells to collagen upon actinidin treatment could be responsible for the cell rounding and give rise to discontinuous breaches in the epithelial monolayer observed in this study. Actinidin's action on cell morphology, adhesion and monolayer integrity were not due to compromised viability of T84 epithelial cells, as confirmed by MTT assay and flow cytometric analysis of the cell cycle. Damage to the epithelial monolayer of the intestine induced by actinidin should be further evaluated as an important factor in the development of kiwifruit allergy and other intestinal disorders.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells",
volume = "77",
pages = "46-52",
doi = "10.1016/j.phytochem.2011.12.014"
}

Čavić, M., Grozdanović, M., Bajić, A., Srdić-Rajić, T., Andjus, P. R.,& Gavrović-Jankulović, M.. (2012). Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 77, 46-52.
https://doi.org/10.1016/j.phytochem.2011.12.014

Čavić M, Grozdanović M, Bajić A, Srdić-Rajić T, Andjus PR, Gavrović-Jankulović M. Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells. in Phytochemistry. 2012;77:46-52.
doi:10.1016/j.phytochem.2011.12.014 .

Čavić, Milena, Grozdanović, Milica, Bajić, Aleksandar, Srdić-Rajić, Tatjana, Andjus, Pavle R., Gavrović-Jankulović, Marija, "Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells" in Phytochemistry, 77 (2012):46-52,
https://doi.org/10.1016/j.phytochem.2011.12.014 . .

TY  - JOUR
AU  - Zec, Manja
AU  - Srdić-Rajić, Tatjana
AU  - Konic-Ristic, Aleksandra
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Filipovic-Ljeskovic, Ivana
AU  - Radulović, Siniša
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1539
AB  - Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
VL  - 12
IS  - 9
SP  - 1071
EP  - 1080
DO  - 10.2174/187152012803529682
ER  - 

@article{
author = "Zec, Manja and Srdić-Rajić, Tatjana and Konic-Ristic, Aleksandra and Todorović, Tamara and Anđelković, Katarina K. and Filipovic-Ljeskovic, Ivana and Radulović, Siniša",
year = "2012",
abstract = "Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones",
volume = "12",
number = "9",
pages = "1071-1080",
doi = "10.2174/187152012803529682"
}

Zec, M., Srdić-Rajić, T., Konic-Ristic, A., Todorović, T., Anđelković, K. K., Filipovic-Ljeskovic, I.,& Radulović, S.. (2012). Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 12(9), 1071-1080.
https://doi.org/10.2174/187152012803529682

Zec M, Srdić-Rajić T, Konic-Ristic A, Todorović T, Anđelković KK, Filipovic-Ljeskovic I, Radulović S. Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry. 2012;12(9):1071-1080.
doi:10.2174/187152012803529682 .

Zec, Manja, Srdić-Rajić, Tatjana, Konic-Ristic, Aleksandra, Todorović, Tamara, Anđelković, Katarina K., Filipovic-Ljeskovic, Ivana, Radulović, Siniša, "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones" in Anti-Cancer Agents in Medicinal Chemistry, 12, no. 9 (2012):1071-1080,
https://doi.org/10.2174/187152012803529682 . .

TY  - JOUR
AU  - Eshkourfu, Rabia
AU  - Čobeljić, Božidar
AU  - Vujčić, Miroslava
AU  - Turel, Iztok
AU  - Pevec, Andrej
AU  - Sepcic, Kristina
AU  - Zec, Manja
AU  - Radulović, Siniša
AU  - Srdić-Rajić, Tatjana
AU  - Mitić, Dragana
AU  - Anđelković, Katarina K.
AU  - Sladić, Dušan
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1191
AB  - A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding. (C) 2011 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
VL  - 105
IS  - 9
SP  - 1196
EP  - 1203
DO  - 10.1016/j.jinorgbio.2011.05.024
ER  - 

@article{
author = "Eshkourfu, Rabia and Čobeljić, Božidar and Vujčić, Miroslava and Turel, Iztok and Pevec, Andrej and Sepcic, Kristina and Zec, Manja and Radulović, Siniša and Srdić-Rajić, Tatjana and Mitić, Dragana and Anđelković, Katarina K. and Sladić, Dušan",
year = "2011",
abstract = "A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding. (C) 2011 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide",
volume = "105",
number = "9",
pages = "1196-1203",
doi = "10.1016/j.jinorgbio.2011.05.024"
}

Eshkourfu, R., Čobeljić, B., Vujčić, M., Turel, I., Pevec, A., Sepcic, K., Zec, M., Radulović, S., Srdić-Rajić, T., Mitić, D., Anđelković, K. K.,& Sladić, D.. (2011). Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 105(9), 1196-1203.
https://doi.org/10.1016/j.jinorgbio.2011.05.024

Eshkourfu R, Čobeljić B, Vujčić M, Turel I, Pevec A, Sepcic K, Zec M, Radulović S, Srdić-Rajić T, Mitić D, Anđelković KK, Sladić D. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry. 2011;105(9):1196-1203.
doi:10.1016/j.jinorgbio.2011.05.024 .

Eshkourfu, Rabia, Čobeljić, Božidar, Vujčić, Miroslava, Turel, Iztok, Pevec, Andrej, Sepcic, Kristina, Zec, Manja, Radulović, Siniša, Srdić-Rajić, Tatjana, Mitić, Dragana, Anđelković, Katarina K., Sladić, Dušan, "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide" in Journal of Inorganic Biochemistry, 105, no. 9 (2011):1196-1203,
https://doi.org/10.1016/j.jinorgbio.2011.05.024 . .

TY  - JOUR
AU  - Srdić-Rajić, Tatjana
AU  - Zec, Manja
AU  - Todorović, Tamara
AU  - Anđelković, Katarina K.
AU  - Radulović, Siniša
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1200
AB  - We previously published the synthesis, characterization and cytotoxic effect of the novel Zn(II), Ni(II), and Cd(II) complexes with 2-formylpyridine selenosemicarbazone. Here we further investigate the mechanism of their antiproliferative activity against several cancer and vascular endothelial cell lines and compared it to the activity of the ligand itself, corresponding salts and, as a referent compound, cisplatin. Investigated complexes induced apoptosis in a time- and dose-dependent manner as well as changes in a cell cycle distribution. Caspase-3 activation in HeLa cells, MDA-MB-361 and vascular endothelial cells EA.hy 926 cells by ligand alone, as well as Zn(II), Ni(II), and Cd(II) complexes was preceded by the activation of the p53 tumor-suppressor gene family protein p73. In addition to activation of p73, these compounds also trigger cytochrome C release by upregulation of Bax expression. The release of cytochrome C has been linked to loss of mitochondrial membrane potential. However, our data indicated that the increased phosphorylation of ERK could be also one of the mechanism involved in the Zn(II), and Cd(II) complexes- induction of apoptosis. Selenosemicarbazone complexes with Cd(II) and Ni(II), possess dual ability to induce apoptosis as well as necrosis, and might present an added advantage for inducing cell death in a diverse array of malignant cells. Taken together, our findings could indicate potential role of these complexes as activator of cross-talk between different signaling pathways that leads to cell death, and thus making the complex intriguing field for further scientific, and maybe clinical investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway
VL  - 46
IS  - 9
SP  - 3734
EP  - 3747
DO  - 10.1016/j.ejmech.2011.05.039
ER  - 

@article{
author = "Srdić-Rajić, Tatjana and Zec, Manja and Todorović, Tamara and Anđelković, Katarina K. and Radulović, Siniša",
year = "2011",
abstract = "We previously published the synthesis, characterization and cytotoxic effect of the novel Zn(II), Ni(II), and Cd(II) complexes with 2-formylpyridine selenosemicarbazone. Here we further investigate the mechanism of their antiproliferative activity against several cancer and vascular endothelial cell lines and compared it to the activity of the ligand itself, corresponding salts and, as a referent compound, cisplatin. Investigated complexes induced apoptosis in a time- and dose-dependent manner as well as changes in a cell cycle distribution. Caspase-3 activation in HeLa cells, MDA-MB-361 and vascular endothelial cells EA.hy 926 cells by ligand alone, as well as Zn(II), Ni(II), and Cd(II) complexes was preceded by the activation of the p53 tumor-suppressor gene family protein p73. In addition to activation of p73, these compounds also trigger cytochrome C release by upregulation of Bax expression. The release of cytochrome C has been linked to loss of mitochondrial membrane potential. However, our data indicated that the increased phosphorylation of ERK could be also one of the mechanism involved in the Zn(II), and Cd(II) complexes- induction of apoptosis. Selenosemicarbazone complexes with Cd(II) and Ni(II), possess dual ability to induce apoptosis as well as necrosis, and might present an added advantage for inducing cell death in a diverse array of malignant cells. Taken together, our findings could indicate potential role of these complexes as activator of cross-talk between different signaling pathways that leads to cell death, and thus making the complex intriguing field for further scientific, and maybe clinical investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway",
volume = "46",
number = "9",
pages = "3734-3747",
doi = "10.1016/j.ejmech.2011.05.039"
}

Srdić-Rajić, T., Zec, M., Todorović, T., Anđelković, K. K.,& Radulović, S.. (2011). Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 46(9), 3734-3747.
https://doi.org/10.1016/j.ejmech.2011.05.039

Srdić-Rajić T, Zec M, Todorović T, Anđelković KK, Radulović S. Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway. in European Journal of Medicinal Chemistry. 2011;46(9):3734-3747.
doi:10.1016/j.ejmech.2011.05.039 .

Srdić-Rajić, Tatjana, Zec, Manja, Todorović, Tamara, Anđelković, Katarina K., Radulović, Siniša, "Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway" in European Journal of Medicinal Chemistry, 46, no. 9 (2011):3734-3747,
https://doi.org/10.1016/j.ejmech.2011.05.039 . .

TY  - CONF
AU  - Zec, M. M.
AU  - Srdić-Rajić, Tatjana
AU  - Anđelković, Katarina K.
AU  - Radulović, Siniša
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1343
PB  - Oxford Univ Press, Oxford
C3  - Annals of Oncology
T1  - Development of Novel Selenosemicarbazones' Complexes in Targeting Apoptotic Signal Pathways in Human Metastatic Breast Cancer Cell Line Mda-Mb-361
VL  - 22
SP  - 55
EP  - 55
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1343
ER  - 

@conference{
author = "Zec, M. M. and Srdić-Rajić, Tatjana and Anđelković, Katarina K. and Radulović, Siniša",
year = "2011",
publisher = "Oxford Univ Press, Oxford",
journal = "Annals of Oncology",
title = "Development of Novel Selenosemicarbazones' Complexes in Targeting Apoptotic Signal Pathways in Human Metastatic Breast Cancer Cell Line Mda-Mb-361",
volume = "22",
pages = "55-55",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1343"
}

Zec, M. M., Srdić-Rajić, T., Anđelković, K. K.,& Radulović, S.. (2011). Development of Novel Selenosemicarbazones' Complexes in Targeting Apoptotic Signal Pathways in Human Metastatic Breast Cancer Cell Line Mda-Mb-361. in Annals of Oncology
Oxford Univ Press, Oxford., 22, 55-55.
https://hdl.handle.net/21.15107/rcub_cherry_1343

Zec MM, Srdić-Rajić T, Anđelković KK, Radulović S. Development of Novel Selenosemicarbazones' Complexes in Targeting Apoptotic Signal Pathways in Human Metastatic Breast Cancer Cell Line Mda-Mb-361. in Annals of Oncology. 2011;22:55-55.
https://hdl.handle.net/21.15107/rcub_cherry_1343 .

Zec, M. M., Srdić-Rajić, Tatjana, Anđelković, Katarina K., Radulović, Siniša, "Development of Novel Selenosemicarbazones' Complexes in Targeting Apoptotic Signal Pathways in Human Metastatic Breast Cancer Cell Line Mda-Mb-361" in Annals of Oncology, 22 (2011):55-55,
https://hdl.handle.net/21.15107/rcub_cherry_1343 .

TY  - JOUR
AU  - Bjelogrlić, Snežana K.
AU  - Todorović, Tamara
AU  - Bacchi, Alessia
AU  - Zec, Manja
AU  - Sladić, Dušan
AU  - Srdić-Rajić, Tatjana
AU  - Radanović, Dušanka D.
AU  - Radulović, Siniša
AU  - Pelizzi, Giancarlo
AU  - Anđelković, Katarina K.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1081
AB  - Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes
VL  - 104
IS  - 6
SP  - 673
EP  - 682
DO  - 10.1016/j.jinorgbio.2010.02.009
ER  - 

@article{
author = "Bjelogrlić, Snežana K. and Todorović, Tamara and Bacchi, Alessia and Zec, Manja and Sladić, Dušan and Srdić-Rajić, Tatjana and Radanović, Dušanka D. and Radulović, Siniša and Pelizzi, Giancarlo and Anđelković, Katarina K.",
year = "2010",
abstract = "Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes",
volume = "104",
number = "6",
pages = "673-682",
doi = "10.1016/j.jinorgbio.2010.02.009"
}

Bjelogrlić, S. K., Todorović, T., Bacchi, A., Zec, M., Sladić, D., Srdić-Rajić, T., Radanović, D. D., Radulović, S., Pelizzi, G.,& Anđelković, K. K.. (2010). Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 104(6), 673-682.
https://doi.org/10.1016/j.jinorgbio.2010.02.009

Bjelogrlić SK, Todorović T, Bacchi A, Zec M, Sladić D, Srdić-Rajić T, Radanović DD, Radulović S, Pelizzi G, Anđelković KK. Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry. 2010;104(6):673-682.
doi:10.1016/j.jinorgbio.2010.02.009 .

Bjelogrlić, Snežana K., Todorović, Tamara, Bacchi, Alessia, Zec, Manja, Sladić, Dušan, Srdić-Rajić, Tatjana, Radanović, Dušanka D., Radulović, Siniša, Pelizzi, Giancarlo, Anđelković, Katarina K., "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes" in Journal of Inorganic Biochemistry, 104, no. 6 (2010):673-682,
https://doi.org/10.1016/j.jinorgbio.2010.02.009 . .

TY  - JOUR
AU  - Malesevic, Nevenka
AU  - Srdić, Tatjana
AU  - Radulović, Siniša
AU  - Sladić, Dušan
AU  - Radulovic, Vesna
AU  - Brčeski, Ilija
AU  - Anđelković, Katarina K.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/762
AB  - A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes
VL  - 100
IS  - 11
SP  - 1811
EP  - 1818
DO  - 10.1016/j.jinorgbio.2006.07.002
ER  - 

@article{
author = "Malesevic, Nevenka and Srdić, Tatjana and Radulović, Siniša and Sladić, Dušan and Radulovic, Vesna and Brčeski, Ilija and Anđelković, Katarina K.",
year = "2006",
abstract = "A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes",
volume = "100",
number = "11",
pages = "1811-1818",
doi = "10.1016/j.jinorgbio.2006.07.002"
}

Malesevic, N., Srdić, T., Radulović, S., Sladić, D., Radulovic, V., Brčeski, I.,& Anđelković, K. K.. (2006). Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 100(11), 1811-1818.
https://doi.org/10.1016/j.jinorgbio.2006.07.002

Malesevic N, Srdić T, Radulović S, Sladić D, Radulovic V, Brčeski I, Anđelković KK. Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry. 2006;100(11):1811-1818.
doi:10.1016/j.jinorgbio.2006.07.002 .

Malesevic, Nevenka, Srdić, Tatjana, Radulović, Siniša, Sladić, Dušan, Radulovic, Vesna, Brčeski, Ilija, Anđelković, Katarina K., "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes" in Journal of Inorganic Biochemistry, 100, no. 11 (2006):1811-1818,
https://doi.org/10.1016/j.jinorgbio.2006.07.002 . .