TY  - JOUR
AU  - Šmigić, Jelena
AU  - Sabo, Tibor
AU  - Vranić, Aleksandra
AU  - Živković, Vladimir
AU  - Srejović, Ivan
AU  - Turnić, Tamara N.
AU  - Milosavljević, Isidora
AU  - Poljarević, Jelena
AU  - Krivokapić, Miloš
AU  - Bolevich, Sergey
AU  - Jakovljević, Vladimir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3721
AB  - The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a week for 4 weeks with different substances; experimental groups received cisplatin, ligand and octahedral platinum(IV) complex, and control groups received saline and dimethyl sulfoxide. After sacrificing the animals, hearts were isolated and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). The following parameters of cardiac function were continuously recorded: maximum and minimum rate of change of pressure in the left ventricle, systolic and diastolic left ventricular pressure, heart rate and coronary flow. The results showed statistically significant differences between all experimental groups in maximum and minimum rate of pressure development as well as in systolic pressure of the left ventricle, whereas cisplatin, ligand and the platinum(IV) complex had effects on heart contractility without significant influences on coronary circulation. The findings of the present study could be important for a better understanding of anticancer drug cardiac side effects. Our results indicate that compared to cisplatin as a “gold standard”, novel platinum complexes and ligands do not possess fewer negative effects on the heart, indicating insufficient safety for their usage in terms of affecting cardiac function, a result that can be of great interest for further investigations.
PB  - Springer Science+Business Media, LLC
T2  - Molecular and Cellular Biochemistry
T1  - Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin
VL  - 458
IS  - 1-2
SP  - 89
EP  - 98
DO  - 10.1007/s11010-019-03533-8
ER  - 

@article{
author = "Šmigić, Jelena and Sabo, Tibor and Vranić, Aleksandra and Živković, Vladimir and Srejović, Ivan and Turnić, Tamara N. and Milosavljević, Isidora and Poljarević, Jelena and Krivokapić, Miloš and Bolevich, Sergey and Jakovljević, Vladimir",
year = "2019",
abstract = "The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old) were divided into five groups: three experimental and two control groups. Animals in all groups were treated with a dose of 4 mg/kg body weight once a week for 4 weeks with different substances; experimental groups received cisplatin, ligand and octahedral platinum(IV) complex, and control groups received saline and dimethyl sulfoxide. After sacrificing the animals, hearts were isolated and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40–120 cmH2O). The following parameters of cardiac function were continuously recorded: maximum and minimum rate of change of pressure in the left ventricle, systolic and diastolic left ventricular pressure, heart rate and coronary flow. The results showed statistically significant differences between all experimental groups in maximum and minimum rate of pressure development as well as in systolic pressure of the left ventricle, whereas cisplatin, ligand and the platinum(IV) complex had effects on heart contractility without significant influences on coronary circulation. The findings of the present study could be important for a better understanding of anticancer drug cardiac side effects. Our results indicate that compared to cisplatin as a “gold standard”, novel platinum complexes and ligands do not possess fewer negative effects on the heart, indicating insufficient safety for their usage in terms of affecting cardiac function, a result that can be of great interest for further investigations.",
publisher = "Springer Science+Business Media, LLC",
journal = "Molecular and Cellular Biochemistry",
title = "Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin",
volume = "458",
number = "1-2",
pages = "89-98",
doi = "10.1007/s11010-019-03533-8"
}

Šmigić, J., Sabo, T., Vranić, A., Živković, V., Srejović, I., Turnić, T. N., Milosavljević, I., Poljarević, J., Krivokapić, M., Bolevich, S.,& Jakovljević, V.. (2019). Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin. in Molecular and Cellular Biochemistry
Springer Science+Business Media, LLC., 458(1-2), 89-98.
https://doi.org/10.1007/s11010-019-03533-8

Šmigić J, Sabo T, Vranić A, Živković V, Srejović I, Turnić TN, Milosavljević I, Poljarević J, Krivokapić M, Bolevich S, Jakovljević V. Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin. in Molecular and Cellular Biochemistry. 2019;458(1-2):89-98.
doi:10.1007/s11010-019-03533-8 .

Šmigić, Jelena, Sabo, Tibor, Vranić, Aleksandra, Živković, Vladimir, Srejović, Ivan, Turnić, Tamara N., Milosavljević, Isidora, Poljarević, Jelena, Krivokapić, Miloš, Bolevich, Sergey, Jakovljević, Vladimir, "Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin" in Molecular and Cellular Biochemistry, 458, no. 1-2 (2019):89-98,
https://doi.org/10.1007/s11010-019-03533-8 . .