TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Trišović, Nemanja
AU  - Andrić, Filip
AU  - Mladenović, Aleksandar
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4419
AB  - The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 µM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 µM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.
PB  - Springer International Publishing
T2  - Monatshefte für Chemie - Chemical Monthly
T2  - Monatshefte für Chemie - Chemical MonthlyMonatsh Chem
T1  - Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution
VL  - 152
IS  - 2
SP  - 185
EP  - 192
DO  - 10.1007/s00706-021-02745-3
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Trišović, Nemanja and Andrić, Filip and Mladenović, Aleksandar and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2021",
abstract = "The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 µM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 µM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.",
publisher = "Springer International Publishing",
journal = "Monatshefte für Chemie - Chemical Monthly, Monatshefte für Chemie - Chemical MonthlyMonatsh Chem",
title = "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution",
volume = "152",
number = "2",
pages = "185-192",
doi = "10.1007/s00706-021-02745-3"
}

Lović, J., Lađarević, J., Trišović, N., Andrić, F., Mladenović, A., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov Ivić, M.. (2021). Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly
Springer International Publishing., 152(2), 185-192.
https://doi.org/10.1007/s00706-021-02745-3

Lović J, Lađarević J, Trišović N, Andrić F, Mladenović A, Mijin D, Vuković D, Petrović SD, Avramov Ivić M. Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly. 2021;152(2):185-192.
doi:10.1007/s00706-021-02745-3 .

Lović, Jelena, Lađarević, Jelena, Trišović, Nemanja, Andrić, Filip, Mladenović, Aleksandar, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution" in Monatshefte für Chemie - Chemical Monthly, 152, no. 2 (2021):185-192,
https://doi.org/10.1007/s00706-021-02745-3 . .

TY  - DATA
AU  - Matijević, Borko M.
AU  - Vaštag, Đenđi Đ.
AU  - Apostolov, Suzana L.
AU  - Milčić, Miloš K.
AU  - Marinković, Aleksandar
AU  - Petrović, Slobodan D.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3386
T2  - Arabian Journal of Chemistry
T1  - Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3386
ER  - 

@misc{
author = "Matijević, Borko M. and Vaštag, Đenđi Đ. and Apostolov, Suzana L. and Milčić, Miloš K. and Marinković, Aleksandar and Petrović, Slobodan D.",
year = "2015",
journal = "Arabian Journal of Chemistry",
title = "Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3386"
}

Matijević, B. M., Vaštag, Đ. Đ., Apostolov, S. L., Milčić, M. K., Marinković, A.,& Petrović, S. D.. (2015). Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008. in Arabian Journal of Chemistry.
https://hdl.handle.net/21.15107/rcub_cherry_3386

Matijević BM, Vaštag ĐĐ, Apostolov SL, Milčić MK, Marinković A, Petrović SD. Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008. in Arabian Journal of Chemistry. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3386 .

Matijević, Borko M., Vaštag, Đenđi Đ., Apostolov, Suzana L., Milčić, Miloš K., Marinković, Aleksandar, Petrović, Slobodan D., "Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008" in Arabian Journal of Chemistry (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3386 .

TY  - JOUR
AU  - Matijević, Borko M.
AU  - Vaštag, Đenđi Đ.
AU  - Apostolov, Suzana L.
AU  - Milčić, Miloš K.
AU  - Marinković, Aleksandar
AU  - Petrović, Slobodan D.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/293
AB  - The UV absorption spectra of twelve. N-(substituted phenyl)-2-chloroacetamides were recorded in eighteen solvents. The effect of specific and non-specific solvent-solute interactions on the absorption maxima shifts was evaluated by using the Kamlet-Taft solvent parameter set,. i.e. applying linear solvation energy relationships (LSER) principles. Optimized geometries and experimental results were interpreted by using DFT (B3LYP/6-311+G(d,p) method) and time-dependent density functional (TD-DFT) method. Overall electron density in both ground and excited state was obtained by the use of Quantum Theory of Atoms in Molecules,. i.e. Bader's analysis. It was found that both solvent and substituents cause appropriate change of the extent of conjugation in the molecules that further affect their intra-molecular charge transfer (ICT) character. Linear free energy relationships (LFERs) were applied to the substituent-induced NMR chemical shifts (SCS) using single substituent parameter (SSP) and dual substituent parameter (DSP) model. Transmission mode of the electronic effects of substituent was discussed according to the results of theoretical calculations and results of LFER correlations. Comparative analysis of presented results with the ones published for structurally similar series of amide which contained cyano group, instead chlorine, provides additional information on the impact of present group to the properties of investigated compound.
T2  - Arabian Journal of Chemistry
T1  - N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study
DO  - 10.1016/j.arabjc.2015.09.008
ER  - 

@article{
author = "Matijević, Borko M. and Vaštag, Đenđi Đ. and Apostolov, Suzana L. and Milčić, Miloš K. and Marinković, Aleksandar and Petrović, Slobodan D.",
year = "2015",
abstract = "The UV absorption spectra of twelve. N-(substituted phenyl)-2-chloroacetamides were recorded in eighteen solvents. The effect of specific and non-specific solvent-solute interactions on the absorption maxima shifts was evaluated by using the Kamlet-Taft solvent parameter set,. i.e. applying linear solvation energy relationships (LSER) principles. Optimized geometries and experimental results were interpreted by using DFT (B3LYP/6-311+G(d,p) method) and time-dependent density functional (TD-DFT) method. Overall electron density in both ground and excited state was obtained by the use of Quantum Theory of Atoms in Molecules,. i.e. Bader's analysis. It was found that both solvent and substituents cause appropriate change of the extent of conjugation in the molecules that further affect their intra-molecular charge transfer (ICT) character. Linear free energy relationships (LFERs) were applied to the substituent-induced NMR chemical shifts (SCS) using single substituent parameter (SSP) and dual substituent parameter (DSP) model. Transmission mode of the electronic effects of substituent was discussed according to the results of theoretical calculations and results of LFER correlations. Comparative analysis of presented results with the ones published for structurally similar series of amide which contained cyano group, instead chlorine, provides additional information on the impact of present group to the properties of investigated compound.",
journal = "Arabian Journal of Chemistry",
title = "N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study",
doi = "10.1016/j.arabjc.2015.09.008"
}

Matijević, B. M., Vaštag, Đ. Đ., Apostolov, S. L., Milčić, M. K., Marinković, A.,& Petrović, S. D.. (2015). N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study. in Arabian Journal of Chemistry.
https://doi.org/10.1016/j.arabjc.2015.09.008

Matijević BM, Vaštag ĐĐ, Apostolov SL, Milčić MK, Marinković A, Petrović SD. N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study. in Arabian Journal of Chemistry. 2015;.
doi:10.1016/j.arabjc.2015.09.008 .

Matijević, Borko M., Vaštag, Đenđi Đ., Apostolov, Suzana L., Milčić, Miloš K., Marinković, Aleksandar, Petrović, Slobodan D., "N-(substituted phenyl)-2-chloroacetamides: LSER and LFER study" in Arabian Journal of Chemistry (2015),
https://doi.org/10.1016/j.arabjc.2015.09.008 . .