TY  - JOUR
AU  - Đurašević, Siniša
AU  - Jama, Adel
AU  - Jasnić, Nebojša
AU  - Vujovic, Predrag
AU  - Jovanović, Miloš
AU  - Mitić-Ćulafić, Dragana
AU  - Knežević-Vukčević, Jelena
AU  - Cakić Milosević, Maja
AU  - Ilijević, Konstantin
AU  - Popović-Đorđević, Jelena
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2401
AB  - One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated. The cadmium concentration was measured in the blood, liver, kidney, and feces, as well as the blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as biomarkers of the liver function. Histomorphological changes in the liver and kidney were also determined. Our results revealed that probiotics combined with cadmium increase this metal concentration in feces. As a result, blood, liver, and kidney Cd levels, as well as blood ALT and AST activities were lessened compared to the rat group treated with cadmium only. Besides, probiotics consumed simultaneously with cadmium attenuated histomorphological changes in the liver and kidney caused by cadmium. The rise in lactobacilli number in feces of rats treated simultaneously with cadmium and probiotics results in strong correlation with the increase of Cd concentration in their feces and the decrease of Cd concentration in their blood. We speculate that probiotics actively contribute to cadmium excretion through feces, probably, by its binding to their bacterial cell wall.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats
VL  - 20
IS  - 2
SP  - 189
EP  - 196
DO  - 10.1089/jmf.2016.0090
ER  - 

@article{
author = "Đurašević, Siniša and Jama, Adel and Jasnić, Nebojša and Vujovic, Predrag and Jovanović, Miloš and Mitić-Ćulafić, Dragana and Knežević-Vukčević, Jelena and Cakić Milosević, Maja and Ilijević, Konstantin and Popović-Đorđević, Jelena",
year = "2017",
abstract = "One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated. The cadmium concentration was measured in the blood, liver, kidney, and feces, as well as the blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as biomarkers of the liver function. Histomorphological changes in the liver and kidney were also determined. Our results revealed that probiotics combined with cadmium increase this metal concentration in feces. As a result, blood, liver, and kidney Cd levels, as well as blood ALT and AST activities were lessened compared to the rat group treated with cadmium only. Besides, probiotics consumed simultaneously with cadmium attenuated histomorphological changes in the liver and kidney caused by cadmium. The rise in lactobacilli number in feces of rats treated simultaneously with cadmium and probiotics results in strong correlation with the increase of Cd concentration in their feces and the decrease of Cd concentration in their blood. We speculate that probiotics actively contribute to cadmium excretion through feces, probably, by its binding to their bacterial cell wall.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats",
volume = "20",
number = "2",
pages = "189-196",
doi = "10.1089/jmf.2016.0090"
}

Đurašević, S., Jama, A., Jasnić, N., Vujovic, P., Jovanović, M., Mitić-Ćulafić, D., Knežević-Vukčević, J., Cakić Milosević, M., Ilijević, K.,& Popović-Đorđević, J.. (2017). The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 20(2), 189-196.
https://doi.org/10.1089/jmf.2016.0090

Đurašević S, Jama A, Jasnić N, Vujovic P, Jovanović M, Mitić-Ćulafić D, Knežević-Vukčević J, Cakić Milosević M, Ilijević K, Popović-Đorđević J. The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats. in Journal of Medicinal Food. 2017;20(2):189-196.
doi:10.1089/jmf.2016.0090 .

Đurašević, Siniša, Jama, Adel, Jasnić, Nebojša, Vujovic, Predrag, Jovanović, Miloš, Mitić-Ćulafić, Dragana, Knežević-Vukčević, Jelena, Cakić Milosević, Maja, Ilijević, Konstantin, Popović-Đorđević, Jelena, "The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats" in Journal of Medicinal Food, 20, no. 2 (2017):189-196,
https://doi.org/10.1089/jmf.2016.0090 . .

TY  - DATA
AU  - Mitić-Ćulafić, Dragana
AU  - Nikolić, Biljana
AU  - Simin, Nataša
AU  - Jasnić, Nebojša
AU  - Četojević-Simin, Dragana
AU  - Krstić-Ristivojević, Maja
AU  - Knežević-Vukčević, Jelena
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3482
PB  - Springer, Dordrecht
T2  - Plant Foods for Human Nutrition
T1  - Supplementary data for the article: Mitic-Culafic, D.; Nikolic, B.; Simin, N.; Jasnic, N.; Cetojevic-Simin, D.; Krstic, M.; Knezevic-Vukcevic, J. Effect of Allium Flavum L. and Allium Melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. Plant Food Hum. Nutr. 2016, 71 (1), 28–34. https://doi.org/10.1007/s11130-015-0519-0
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3482
ER  - 

@misc{
author = "Mitić-Ćulafić, Dragana and Nikolić, Biljana and Simin, Nataša and Jasnić, Nebojša and Četojević-Simin, Dragana and Krstić-Ristivojević, Maja and Knežević-Vukčević, Jelena",
year = "2016",
publisher = "Springer, Dordrecht",
journal = "Plant Foods for Human Nutrition",
title = "Supplementary data for the article: Mitic-Culafic, D.; Nikolic, B.; Simin, N.; Jasnic, N.; Cetojevic-Simin, D.; Krstic, M.; Knezevic-Vukcevic, J. Effect of Allium Flavum L. and Allium Melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. Plant Food Hum. Nutr. 2016, 71 (1), 28–34. https://doi.org/10.1007/s11130-015-0519-0",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3482"
}

Mitić-Ćulafić, D., Nikolić, B., Simin, N., Jasnić, N., Četojević-Simin, D., Krstić-Ristivojević, M.,& Knežević-Vukčević, J.. (2016). Supplementary data for the article: Mitic-Culafic, D.; Nikolic, B.; Simin, N.; Jasnic, N.; Cetojevic-Simin, D.; Krstic, M.; Knezevic-Vukcevic, J. Effect of Allium Flavum L. and Allium Melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. Plant Food Hum. Nutr. 2016, 71 (1), 28–34. https://doi.org/10.1007/s11130-015-0519-0. in Plant Foods for Human Nutrition
Springer, Dordrecht..
https://hdl.handle.net/21.15107/rcub_cherry_3482

Mitić-Ćulafić D, Nikolić B, Simin N, Jasnić N, Četojević-Simin D, Krstić-Ristivojević M, Knežević-Vukčević J. Supplementary data for the article: Mitic-Culafic, D.; Nikolic, B.; Simin, N.; Jasnic, N.; Cetojevic-Simin, D.; Krstic, M.; Knezevic-Vukcevic, J. Effect of Allium Flavum L. and Allium Melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. Plant Food Hum. Nutr. 2016, 71 (1), 28–34. https://doi.org/10.1007/s11130-015-0519-0. in Plant Foods for Human Nutrition. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3482 .

Mitić-Ćulafić, Dragana, Nikolić, Biljana, Simin, Nataša, Jasnić, Nebojša, Četojević-Simin, Dragana, Krstić-Ristivojević, Maja, Knežević-Vukčević, Jelena, "Supplementary data for the article: Mitic-Culafic, D.; Nikolic, B.; Simin, N.; Jasnic, N.; Cetojevic-Simin, D.; Krstic, M.; Knezevic-Vukcevic, J. Effect of Allium Flavum L. and Allium Melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. Plant Food Hum. Nutr. 2016, 71 (1), 28–34. https://doi.org/10.1007/s11130-015-0519-0" in Plant Foods for Human Nutrition (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3482 .

TY  - JOUR
AU  - Mitić-Ćulafić, Dragana
AU  - Nikolić, Biljana
AU  - Simin, Nataša
AU  - Jasnić, Nebojša
AU  - Četojević-Simin, Dragana
AU  - Krstić-Ristivojević, Maja
AU  - Knežević-Vukčević, Jelena
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2065
AB  - Allium flavum L. and Allium melanantherum Pan. are wild growing plants used in traditional diet in Balkan region. While chemical composition and some biological activities of A. flavum have been reported, A. melanantherum, as an endemic in the Balkan Peninsula, has never been comprehensively examined. After chemical characterization of A. melanantherum, we examined the protective effect of methanol extracts of both species against t-butyl hydro-peroxide (t-BOOH)-induced DNA damage and mutagenesis. The bacterial reverse mutation assay was performed on Escherichia coli WP2 oxyR strain. DNA damage was monitored in human fetal lung fibroblasts (MRC-5) with alkaline comet assay. Obtained results indicated that extracts reduced t-BOOH-induced DNA damage up to 70 and 72 % for A. flavum and A. melanantherum extract, respectively, and showed no effect on t-BOOH-induced mutagenesis. Since the results indicated modulatory effect on cell-mediated antioxidative defense, the effect of extracts on total protein content, and superoxide dismutase (SOD) and catalase (CAT) amounts and activities were monitored. Both extracts increased total protein content, while the increase of enzyme amount and activity was obtained only with A. melanantherum extract and restricted to CAT. The activity of CuZnSOD family was not affected, while SOD1 and SOD2 amounts were significantly decreased, indicating potential involvement of extracellular CuZnSOD. Obtained results strongly support the traditional use of A. flavum and A. melanantherum in nutrition and recommend them for further study.
PB  - Springer, Dordrecht
T2  - Plant Foods for Human Nutrition
T1  - Effect of Allium flavum L. and Allium melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase
VL  - 71
IS  - 1
SP  - 28
EP  - 34
DO  - 10.1007/s11130-015-0519-0
ER  - 

@article{
author = "Mitić-Ćulafić, Dragana and Nikolić, Biljana and Simin, Nataša and Jasnić, Nebojša and Četojević-Simin, Dragana and Krstić-Ristivojević, Maja and Knežević-Vukčević, Jelena",
year = "2016",
abstract = "Allium flavum L. and Allium melanantherum Pan. are wild growing plants used in traditional diet in Balkan region. While chemical composition and some biological activities of A. flavum have been reported, A. melanantherum, as an endemic in the Balkan Peninsula, has never been comprehensively examined. After chemical characterization of A. melanantherum, we examined the protective effect of methanol extracts of both species against t-butyl hydro-peroxide (t-BOOH)-induced DNA damage and mutagenesis. The bacterial reverse mutation assay was performed on Escherichia coli WP2 oxyR strain. DNA damage was monitored in human fetal lung fibroblasts (MRC-5) with alkaline comet assay. Obtained results indicated that extracts reduced t-BOOH-induced DNA damage up to 70 and 72 % for A. flavum and A. melanantherum extract, respectively, and showed no effect on t-BOOH-induced mutagenesis. Since the results indicated modulatory effect on cell-mediated antioxidative defense, the effect of extracts on total protein content, and superoxide dismutase (SOD) and catalase (CAT) amounts and activities were monitored. Both extracts increased total protein content, while the increase of enzyme amount and activity was obtained only with A. melanantherum extract and restricted to CAT. The activity of CuZnSOD family was not affected, while SOD1 and SOD2 amounts were significantly decreased, indicating potential involvement of extracellular CuZnSOD. Obtained results strongly support the traditional use of A. flavum and A. melanantherum in nutrition and recommend them for further study.",
publisher = "Springer, Dordrecht",
journal = "Plant Foods for Human Nutrition",
title = "Effect of Allium flavum L. and Allium melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase",
volume = "71",
number = "1",
pages = "28-34",
doi = "10.1007/s11130-015-0519-0"
}

Mitić-Ćulafić, D., Nikolić, B., Simin, N., Jasnić, N., Četojević-Simin, D., Krstić-Ristivojević, M.,& Knežević-Vukčević, J.. (2016). Effect of Allium flavum L. and Allium melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. in Plant Foods for Human Nutrition
Springer, Dordrecht., 71(1), 28-34.
https://doi.org/10.1007/s11130-015-0519-0

Mitić-Ćulafić D, Nikolić B, Simin N, Jasnić N, Četojević-Simin D, Krstić-Ristivojević M, Knežević-Vukčević J. Effect of Allium flavum L. and Allium melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase. in Plant Foods for Human Nutrition. 2016;71(1):28-34.
doi:10.1007/s11130-015-0519-0 .

Mitić-Ćulafić, Dragana, Nikolić, Biljana, Simin, Nataša, Jasnić, Nebojša, Četojević-Simin, Dragana, Krstić-Ristivojević, Maja, Knežević-Vukčević, Jelena, "Effect of Allium flavum L. and Allium melanantherum Pan. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase" in Plant Foods for Human Nutrition, 71, no. 1 (2016):28-34,
https://doi.org/10.1007/s11130-015-0519-0 . .