TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gaeta, Francesco
AU  - Međo, Biljana
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Tmušić, Vladimir
AU  - Romano, Antonino
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2278
AB  - BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.
PB  - Wiley, Hoboken
T2  - Pediatric Allergy and Immunology
T1  - Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up
VL  - 27
IS  - 5
SP  - 533
EP  - 538
DO  - 10.1111/pai.12565
ER  - 

@article{
author = "Atanasković-Marković, Marina and Gaeta, Francesco and Međo, Biljana and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Tmušić, Vladimir and Romano, Antonino",
year = "2016",
abstract = "BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.",
publisher = "Wiley, Hoboken",
journal = "Pediatric Allergy and Immunology",
title = "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up",
volume = "27",
number = "5",
pages = "533-538",
doi = "10.1111/pai.12565"
}

Atanasković-Marković, M., Gaeta, F., Međo, B., Gavrović-Jankulović, M., Ćirković-Veličković, T., Tmušić, V.,& Romano, A.. (2016). Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology
Wiley, Hoboken., 27(5), 533-538.
https://doi.org/10.1111/pai.12565

Atanasković-Marković M, Gaeta F, Međo B, Gavrović-Jankulović M, Ćirković-Veličković T, Tmušić V, Romano A. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology. 2016;27(5):533-538.
doi:10.1111/pai.12565 .

Atanasković-Marković, Marina, Gaeta, Francesco, Međo, Biljana, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Tmušić, Vladimir, Romano, Antonino, "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up" in Pediatric Allergy and Immunology, 27, no. 5 (2016):533-538,
https://doi.org/10.1111/pai.12565 . .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gaeta, Francesco
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Valluzzi, Rocco Luigi
AU  - Romano, Antonino
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1560
AB  - Background Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of MDH have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose MDH on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking. Methods We conducted a prospective study evaluating children with histories of MDH by skin tests, patch tests, serum-specific IgE assays, and drug provocation tests. Results A MDH was diagnosed in 7 (2.5%) of the 279 children evaluated who completed the study. The responsible drugs were beta-lactams (penicillins and cephalosporins) in 5 episodes, ibuprofen and anticonvulsants in 3, and erythromycin, fentanyl, methylprednisolone, and cotrimoxazole in 1. Sensitivity to 2 chemically different drugs was diagnosed in 6 children and to 3 drugs in 1 child. Two of the 7 children presented the first type of MDH, whereas 5 displayed the second one. Conclusions MDH can occur in children, even to drugs other than antibiotics. It is crucial to evaluate children with histories of MDH using both in vivo and in vitro allergologic tests, including challenges. In fact, such approach allows the physician to confirm the diagnosis of MDH in a small percentage of children with histories of MDH, as well as to rule it out in the great majority of them.
PB  - Wiley-Blackwell, Hoboken
T2  - Pediatric Allergy and Immunology
T1  - Diagnosing multiple drug hypersensitivity in children
VL  - 23
IS  - 8
SP  - 785
EP  - 791
DO  - 10.1111/pai.12020
ER  - 

@article{
author = "Atanasković-Marković, Marina and Gaeta, Francesco and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Valluzzi, Rocco Luigi and Romano, Antonino",
year = "2012",
abstract = "Background Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of MDH have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose MDH on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking. Methods We conducted a prospective study evaluating children with histories of MDH by skin tests, patch tests, serum-specific IgE assays, and drug provocation tests. Results A MDH was diagnosed in 7 (2.5%) of the 279 children evaluated who completed the study. The responsible drugs were beta-lactams (penicillins and cephalosporins) in 5 episodes, ibuprofen and anticonvulsants in 3, and erythromycin, fentanyl, methylprednisolone, and cotrimoxazole in 1. Sensitivity to 2 chemically different drugs was diagnosed in 6 children and to 3 drugs in 1 child. Two of the 7 children presented the first type of MDH, whereas 5 displayed the second one. Conclusions MDH can occur in children, even to drugs other than antibiotics. It is crucial to evaluate children with histories of MDH using both in vivo and in vitro allergologic tests, including challenges. In fact, such approach allows the physician to confirm the diagnosis of MDH in a small percentage of children with histories of MDH, as well as to rule it out in the great majority of them.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Pediatric Allergy and Immunology",
title = "Diagnosing multiple drug hypersensitivity in children",
volume = "23",
number = "8",
pages = "785-791",
doi = "10.1111/pai.12020"
}

Atanasković-Marković, M., Gaeta, F., Gavrović-Jankulović, M., Ćirković-Veličković, T., Valluzzi, R. L.,& Romano, A.. (2012). Diagnosing multiple drug hypersensitivity in children. in Pediatric Allergy and Immunology
Wiley-Blackwell, Hoboken., 23(8), 785-791.
https://doi.org/10.1111/pai.12020

Atanasković-Marković M, Gaeta F, Gavrović-Jankulović M, Ćirković-Veličković T, Valluzzi RL, Romano A. Diagnosing multiple drug hypersensitivity in children. in Pediatric Allergy and Immunology. 2012;23(8):785-791.
doi:10.1111/pai.12020 .

Atanasković-Marković, Marina, Gaeta, Francesco, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Valluzzi, Rocco Luigi, Romano, Antonino, "Diagnosing multiple drug hypersensitivity in children" in Pediatric Allergy and Immunology, 23, no. 8 (2012):785-791,
https://doi.org/10.1111/pai.12020 . .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gaeta, Francesco
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Valluzzi, Rocco Luigi
AU  - Romano, Antonino
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/997
PB  - Mosby-Elsevier, New York
T2  - Journal of Allergy and Clinical Immunology
T1  - Tolerability of imipenem in children with IgE-mediated hypersensitivity to penicillins
VL  - 124
IS  - 1
SP  - 167
EP  - 169
DO  - 10.1016/j.jaci.2009.02.031
ER  - 

@article{
author = "Atanasković-Marković, Marina and Gaeta, Francesco and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Valluzzi, Rocco Luigi and Romano, Antonino",
year = "2009",
publisher = "Mosby-Elsevier, New York",
journal = "Journal of Allergy and Clinical Immunology",
title = "Tolerability of imipenem in children with IgE-mediated hypersensitivity to penicillins",
volume = "124",
number = "1",
pages = "167-169",
doi = "10.1016/j.jaci.2009.02.031"
}

Atanasković-Marković, M., Gaeta, F., Gavrović-Jankulović, M., Ćirković-Veličković, T., Valluzzi, R. L.,& Romano, A.. (2009). Tolerability of imipenem in children with IgE-mediated hypersensitivity to penicillins. in Journal of Allergy and Clinical Immunology
Mosby-Elsevier, New York., 124(1), 167-169.
https://doi.org/10.1016/j.jaci.2009.02.031

Atanasković-Marković M, Gaeta F, Gavrović-Jankulović M, Ćirković-Veličković T, Valluzzi RL, Romano A. Tolerability of imipenem in children with IgE-mediated hypersensitivity to penicillins. in Journal of Allergy and Clinical Immunology. 2009;124(1):167-169.
doi:10.1016/j.jaci.2009.02.031 .

Atanasković-Marković, Marina, Gaeta, Francesco, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Valluzzi, Rocco Luigi, Romano, Antonino, "Tolerability of imipenem in children with IgE-mediated hypersensitivity to penicillins" in Journal of Allergy and Clinical Immunology, 124, no. 1 (2009):167-169,
https://doi.org/10.1016/j.jaci.2009.02.031 . .