TY  - JOUR
AU  - Malesevic, Nevenka
AU  - Srdić, Tatjana
AU  - Radulović, Siniša
AU  - Sladić, Dušan
AU  - Radulovic, Vesna
AU  - Brčeski, Ilija
AU  - Anđelković, Katarina K.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/762
AB  - A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes
VL  - 100
IS  - 11
SP  - 1811
EP  - 1818
DO  - 10.1016/j.jinorgbio.2006.07.002
ER  - 

@article{
author = "Malesevic, Nevenka and Srdić, Tatjana and Radulović, Siniša and Sladić, Dušan and Radulovic, Vesna and Brčeski, Ilija and Anđelković, Katarina K.",
year = "2006",
abstract = "A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes",
volume = "100",
number = "11",
pages = "1811-1818",
doi = "10.1016/j.jinorgbio.2006.07.002"
}

Malesevic, N., Srdić, T., Radulović, S., Sladić, D., Radulovic, V., Brčeski, I.,& Anđelković, K. K.. (2006). Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 100(11), 1811-1818.
https://doi.org/10.1016/j.jinorgbio.2006.07.002

Malesevic N, Srdić T, Radulović S, Sladić D, Radulovic V, Brčeski I, Anđelković KK. Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry. 2006;100(11):1811-1818.
doi:10.1016/j.jinorgbio.2006.07.002 .

Malesevic, Nevenka, Srdić, Tatjana, Radulović, Siniša, Sladić, Dušan, Radulovic, Vesna, Brčeski, Ilija, Anđelković, Katarina K., "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes" in Journal of Inorganic Biochemistry, 100, no. 11 (2006):1811-1818,
https://doi.org/10.1016/j.jinorgbio.2006.07.002 . .