TY  - JOUR
AU  - Sofrenić, Ivana V.
AU  - Anđelković, Boban D.
AU  - Vujisić, Ljubodrag V.
AU  - Novaković, Miroslav M.
AU  - Knežević, Aleksandar
AU  - Stanković, Miroslava

AU  - Milosavljević, Slobodan M.
AU  - Tešević, Vele
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4819
AB  - Eleven 31-methylenlanostane triterpenoids, i.e., seven 21- and four 26-oic acids, as well as a lupane triterpenoid betulin, isolated from the fruiting bodies of the mushroom Fomitopsis betulina, were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. Most of the tested compounds showed a beneficial effect by reducing DNA damage of human lymphocytes more effectively than amifostine, a radioprotective agent, used as a positive control. All the tested compounds decreased MN frequency in the concentration dependent manner, with the concentration of 2.0 µg mL-1 being the most effective – with increase of the concentration the activity slightly decreases. The structure–activity relationship (SAR) studies indicated that the lanostanes containing a conjugated 7,9 (11)-diene system exhibit lower activity than Δ8-analogues. It was also demonstrated that the DNA protective activities within the Δ8-lanostane-26-oic acid group are affected by the substitution in position 3 pattern. In the Δ8 series the oxygenation at C-12 or 16 as well as 21- or 26-oic acid functionality proved beneficial for in vitro protective effect on chromosomal aberrations. Betulin exhibited the lowest protective activity, but it is still comparable to that of amifostine.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina
VL  - 86
IS  - 9
SP  - 809
EP  - 817
DO  - 10.2298/JSC210401039S
ER  - 

@article{
author = "Sofrenić, Ivana V. and Anđelković, Boban D. and Vujisić, Ljubodrag V. and Novaković, Miroslav M. and Knežević, Aleksandar and Stanković, Miroslava
 and Milosavljević, Slobodan M. and Tešević, Vele",
year = "2021",
abstract = "Eleven 31-methylenlanostane triterpenoids, i.e., seven 21- and four 26-oic acids, as well as a lupane triterpenoid betulin, isolated from the fruiting bodies of the mushroom Fomitopsis betulina, were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. Most of the tested compounds showed a beneficial effect by reducing DNA damage of human lymphocytes more effectively than amifostine, a radioprotective agent, used as a positive control. All the tested compounds decreased MN frequency in the concentration dependent manner, with the concentration of 2.0 µg mL-1 being the most effective – with increase of the concentration the activity slightly decreases. The structure–activity relationship (SAR) studies indicated that the lanostanes containing a conjugated 7,9 (11)-diene system exhibit lower activity than Δ8-analogues. It was also demonstrated that the DNA protective activities within the Δ8-lanostane-26-oic acid group are affected by the substitution in position 3 pattern. In the Δ8 series the oxygenation at C-12 or 16 as well as 21- or 26-oic acid functionality proved beneficial for in vitro protective effect on chromosomal aberrations. Betulin exhibited the lowest protective activity, but it is still comparable to that of amifostine.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina",
volume = "86",
number = "9",
pages = "809-817",
doi = "10.2298/JSC210401039S"
}

Sofrenić, I. V., Anđelković, B. D., Vujisić, L. V., Novaković, M. M., Knežević, A., Stanković, M., Milosavljević, S. M.,& Tešević, V.. (2021). DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 86(9), 809-817.
https://doi.org/10.2298/JSC210401039S

Sofrenić IV, Anđelković BD, Vujisić LV, Novaković MM, Knežević A, Stanković M, Milosavljević SM, Tešević V. DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina. in Journal of the Serbian Chemical Society. 2021;86(9):809-817.
doi:10.2298/JSC210401039S .

Sofrenić, Ivana V., Anđelković, Boban D., Vujisić, Ljubodrag V., Novaković, Miroslav M., Knežević, Aleksandar, Stanković, Miroslava
, Milosavljević, Slobodan M., Tešević, Vele, "DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina" in Journal of the Serbian Chemical Society, 86, no. 9 (2021):809-817,
https://doi.org/10.2298/JSC210401039S . .

TY  - JOUR
AU  - Milosavljević, Slobodan M.
AU  - Đorđević, Iris
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Stanković, Miroslava
AU  - Todorović, Nina
AU  - Novaković, Miroslav M.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4838
AB  - In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.
PB  - SAGE Publications
T2  - Natural Product Communications
T1  - Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA
VL  - 16
IS  - 12
SP  - 1
EP  - 8
DO  - 10.1177/1934578X211067289
ER  - 

@article{
author = "Milosavljević, Slobodan M. and Đorđević, Iris and Mandić, Boris and Tešević, Vele and Stanković, Miroslava and Todorović, Nina and Novaković, Miroslav M.",
year = "2021",
abstract = "In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.",
publisher = "SAGE Publications",
journal = "Natural Product Communications",
title = "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA",
volume = "16",
number = "12",
pages = "1-8",
doi = "10.1177/1934578X211067289"
}

Milosavljević, S. M., Đorđević, I., Mandić, B., Tešević, V., Stanković, M., Todorović, N.,& Novaković, M. M.. (2021). Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications
SAGE Publications., 16(12), 1-8.
https://doi.org/10.1177/1934578X211067289

Milosavljević SM, Đorđević I, Mandić B, Tešević V, Stanković M, Todorović N, Novaković MM. Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications. 2021;16(12):1-8.
doi:10.1177/1934578X211067289 .

Milosavljević, Slobodan M., Đorđević, Iris, Mandić, Boris, Tešević, Vele, Stanković, Miroslava, Todorović, Nina, Novaković, Miroslav M., "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA" in Natural Product Communications, 16, no. 12 (2021):1-8,
https://doi.org/10.1177/1934578X211067289 . .

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Aljančić, Ivana
AU  - Vujisić, Ljubodrag V.
AU  - Mandić, Boris
AU  - Tešević, Vele
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3143
AB  - Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).
PB  - SAGE Journals
T2  - Natural Product Communications
T1  - Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA
VL  - 14
IS  - 5
DO  - 10.1177/1934578X19848168
ER  - 

@article{
author = "Krstić, Gordana B. and Jadranin, Milka and Stanković, Miroslava and Aljančić, Ivana and Vujisić, Ljubodrag V. and Mandić, Boris and Tešević, Vele",
year = "2019",
abstract = "Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).",
publisher = "SAGE Journals",
journal = "Natural Product Communications",
title = "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA",
volume = "14",
number = "5",
doi = "10.1177/1934578X19848168"
}

Krstić, G. B., Jadranin, M., Stanković, M., Aljančić, I., Vujisić, L. V., Mandić, B.,& Tešević, V.. (2019). Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications
SAGE Journals., 14(5).
https://doi.org/10.1177/1934578X19848168

Krstić GB, Jadranin M, Stanković M, Aljančić I, Vujisić LV, Mandić B, Tešević V. Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications. 2019;14(5).
doi:10.1177/1934578X19848168 .

Krstić, Gordana B., Jadranin, Milka, Stanković, Miroslava, Aljančić, Ivana, Vujisić, Ljubodrag V., Mandić, Boris, Tešević, Vele, "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA" in Natural Product Communications, 14, no. 5 (2019),
https://doi.org/10.1177/1934578X19848168 . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Milosavljević, Slobodan M.
AU  - Vujisić, Ljubodrag V.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4938
AB  - Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB  - Informa UK Limited
T2  - Natural Product Research
T1  - Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA
SP  - 1
EP  - 9
DO  - 10.1080/14786419.2019.1687470
ER  - 

@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Stanković, Miroslava and Mandić, Boris and Milosavljević, Slobodan M. and Vujisić, Ljubodrag V.",
year = "2019",
abstract = "Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Informa UK Limited",
journal = "Natural Product Research",
title = "Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA",
pages = "1-9",
doi = "10.1080/14786419.2019.1687470"
}

Cvetković, M., Đorđević, I., Jadranin, M., Stanković, M., Mandić, B., Milosavljević, S. M.,& Vujisić, L. V.. (2019). Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA. in Natural Product Research
Informa UK Limited., 1-9.
https://doi.org/10.1080/14786419.2019.1687470

Cvetković M, Đorđević I, Jadranin M, Stanković M, Mandić B, Milosavljević SM, Vujisić LV. Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA. in Natural Product Research. 2019;:1-9.
doi:10.1080/14786419.2019.1687470 .

Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Stanković, Miroslava, Mandić, Boris, Milosavljević, Slobodan M., Vujisić, Ljubodrag V., "Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA" in Natural Product Research (2019):1-9,
https://doi.org/10.1080/14786419.2019.1687470 . .

TY  - JOUR
AU  - Simić, Milena R.
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Savić, Vladimir
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1660
AB  - Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Archiv der Pharmazie
T1  - Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes
VL  - 348
IS  - 2
SP  - 100
EP  - 112
DO  - 10.1002/ardp.201400350
ER  - 

@article{
author = "Simić, Milena R. and Stanković, Miroslava and Mandić, Boris and Tešević, Vele and Savić, Vladimir",
year = "2015",
abstract = "Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Archiv der Pharmazie",
title = "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes",
volume = "348",
number = "2",
pages = "100-112",
doi = "10.1002/ardp.201400350"
}

Simić, M. R., Stanković, M., Mandić, B., Tešević, V.,& Savić, V.. (2015). Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie
Wiley-V C H Verlag Gmbh, Weinheim., 348(2), 100-112.
https://doi.org/10.1002/ardp.201400350

Simić MR, Stanković M, Mandić B, Tešević V, Savić V. Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie. 2015;348(2):100-112.
doi:10.1002/ardp.201400350 .

Simić, Milena R., Stanković, Miroslava, Mandić, Boris, Tešević, Vele, Savić, Vladimir, "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes" in Archiv der Pharmazie, 348, no. 2 (2015):100-112,
https://doi.org/10.1002/ardp.201400350 . .

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Stanković, Miroslava
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Apostolović, Danijela
AU  - Mandić, Boris
AU  - Veljić, Milan
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1793
AB  - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
VL  - 11
IS  - 6
SP  - 872
EP  - 885
DO  - 10.1002/cbdv.201300277
ER  - 

@article{
author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Apostolović, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection",
volume = "11",
number = "6",
pages = "872-885",
doi = "10.1002/cbdv.201300277"
}

Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Apostolović, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885.
https://doi.org/10.1002/cbdv.201300277

Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Apostolović D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity. 2014;11(6):872-885.
doi:10.1002/cbdv.201300277 .

Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Apostolović, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry and Biodiversity, 11, no. 6 (2014):872-885,
https://doi.org/10.1002/cbdv.201300277 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Stanković, Miroslava
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1626
AB  - This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Mini Reviews in Medicinal Chemistry
T1  - Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay
VL  - 13
IS  - 3
SP  - 431
EP  - 438
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1626
ER  - 

@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M. and Stanković, Miroslava",
year = "2013",
abstract = "This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Mini Reviews in Medicinal Chemistry",
title = "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay",
volume = "13",
number = "3",
pages = "431-438",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1626"
}

Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S. M.,& Stanković, M.. (2013). Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini Reviews in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 13(3), 431-438.
https://hdl.handle.net/21.15107/rcub_cherry_1626

Gođevac D, Tešević V, Vajs V, Milosavljević SM, Stanković M. Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini Reviews in Medicinal Chemistry. 2013;13(3):431-438.
https://hdl.handle.net/21.15107/rcub_cherry_1626 .

Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., Stanković, Miroslava, "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay" in Mini Reviews in Medicinal Chemistry, 13, no. 3 (2013):431-438,
https://hdl.handle.net/21.15107/rcub_cherry_1626 .

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Stanković, Miroslava
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1630
AB  - A study of secondary metabolites from the bark of Alnus glutinosa led to the isolation of fourteen diarylheptanoids: oregonin (1), platyphylloside (2), rubranoside A (3), rubranoside B (4), hirsutanonol (5), hirsutenone (6), hirsutanonol-5-O-β-D-glucopyranoside (7), platyphyllonol-5-O-β-D- xylopyranoside (8), aceroside VII (9), alnuside A (10), alnuside B (11), 1,7-bis-(3,4-dihydoxyphenyl)-5-hydroxy-heptane-3-O-β-D-xylopyranoside (12), (5S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)-5-O-β-D-glucopyranosyl- heptan-3-one (13), and (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-O-β-D-[6-(3,4- dimethoxycinnamoylglucopyranosyl)]-heptan-3-one (14). All of the diarylheptanoids, except 1 and 5, were found in A. glutinosa for the first time, while 13 and 14 were new compounds. The structures were determined by spectroscopic techniques: 1D and 2D NMR, HR-ESI-MS, FTIR, UV, and CD. All isolated compounds were analyzed for an in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus assay. The majority of them, including the new compounds 13 and 14, exerted a pronounced effect in decreasing DNA damage in human lymphocytes. Diarylheptanoids 1, 2, 5, 13, and 14 at a concentration of 1 g/mL decreased the frequency of micronuclei by 52.8 %, 43.8 %, 63.6 %, 44.4 %, and 56.0 %, respectively, exerting a much stronger effect than the synthetic protector amifostine (17.2 %, c = 1 g/mL).
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA
VL  - 79
IS  - 6
SP  - 499
EP  - 505
DO  - 10.1055/s-0032-1328301
ER  - 

@article{
author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2013",
abstract = "A study of secondary metabolites from the bark of Alnus glutinosa led to the isolation of fourteen diarylheptanoids: oregonin (1), platyphylloside (2), rubranoside A (3), rubranoside B (4), hirsutanonol (5), hirsutenone (6), hirsutanonol-5-O-β-D-glucopyranoside (7), platyphyllonol-5-O-β-D- xylopyranoside (8), aceroside VII (9), alnuside A (10), alnuside B (11), 1,7-bis-(3,4-dihydoxyphenyl)-5-hydroxy-heptane-3-O-β-D-xylopyranoside (12), (5S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)-5-O-β-D-glucopyranosyl- heptan-3-one (13), and (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-O-β-D-[6-(3,4- dimethoxycinnamoylglucopyranosyl)]-heptan-3-one (14). All of the diarylheptanoids, except 1 and 5, were found in A. glutinosa for the first time, while 13 and 14 were new compounds. The structures were determined by spectroscopic techniques: 1D and 2D NMR, HR-ESI-MS, FTIR, UV, and CD. All isolated compounds were analyzed for an in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus assay. The majority of them, including the new compounds 13 and 14, exerted a pronounced effect in decreasing DNA damage in human lymphocytes. Diarylheptanoids 1, 2, 5, 13, and 14 at a concentration of 1 g/mL decreased the frequency of micronuclei by 52.8 %, 43.8 %, 63.6 %, 44.4 %, and 56.0 %, respectively, exerting a much stronger effect than the synthetic protector amifostine (17.2 %, c = 1 g/mL).",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA",
volume = "79",
number = "6",
pages = "499-505",
doi = "10.1055/s-0032-1328301"
}

Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2013). Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 79(6), 499-505.
https://doi.org/10.1055/s-0032-1328301

Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. in Planta Medica. 2013;79(6):499-505.
doi:10.1055/s-0032-1328301 .

Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA" in Planta Medica, 79, no. 6 (2013):499-505,
https://doi.org/10.1055/s-0032-1328301 . .

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Stanković, Miroslava
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3484
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Supplementary data for article: Novaković, M. M.; Stanković, M.; Vučković, I. M.; Todorović, N.; Trifunović, S. S.; Tešević, V.; Vajs, V.; Milosavljević, S. M. Diarylheptanoids from Alnus Glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. Planta Medica 2013, 79 (6), 499–505. https://doi.org/10.1055/s-0032-1328301
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3484
ER  - 

@misc{
author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2013",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Supplementary data for article: Novaković, M. M.; Stanković, M.; Vučković, I. M.; Todorović, N.; Trifunović, S. S.; Tešević, V.; Vajs, V.; Milosavljević, S. M. Diarylheptanoids from Alnus Glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. Planta Medica 2013, 79 (6), 499–505. https://doi.org/10.1055/s-0032-1328301",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3484"
}

Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2013). Supplementary data for article: Novaković, M. M.; Stanković, M.; Vučković, I. M.; Todorović, N.; Trifunović, S. S.; Tešević, V.; Vajs, V.; Milosavljević, S. M. Diarylheptanoids from Alnus Glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. Planta Medica 2013, 79 (6), 499–505. https://doi.org/10.1055/s-0032-1328301. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart..
https://hdl.handle.net/21.15107/rcub_cherry_3484

Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Tešević V, Vajs V, Milosavljević SM. Supplementary data for article: Novaković, M. M.; Stanković, M.; Vučković, I. M.; Todorović, N.; Trifunović, S. S.; Tešević, V.; Vajs, V.; Milosavljević, S. M. Diarylheptanoids from Alnus Glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. Planta Medica 2013, 79 (6), 499–505. https://doi.org/10.1055/s-0032-1328301. in Planta Medica. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3484 .

Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Supplementary data for article: Novaković, M. M.; Stanković, M.; Vučković, I. M.; Todorović, N.; Trifunović, S. S.; Tešević, V.; Vajs, V.; Milosavljević, S. M. Diarylheptanoids from Alnus Glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. Planta Medica 2013, 79 (6), 499–505. https://doi.org/10.1055/s-0032-1328301" in Planta Medica (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3484 .

TY  - JOUR
AU  - Vulic, Todor
AU  - Nikićević, Ninoslav
AU  - Stanković, Ljubisa
AU  - Veličković, Milovan
AU  - Todosijević, Marina
AU  - Popovic, Branko
AU  - Urosevic, Ivan
AU  - Stanković, Miroslava
AU  - Beraha, Isidora
AU  - Tešević, Vele
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1580
AB  - The chemical characteristics of fruit spirits produced from three black currant cultivars (Mailing Juel, Ometa and Ben Sarek) and two red currant cultivars (Rondom and Versailles) grown in Serbia were examined using gas chromatography. In addition, a sensory evaluation of the spirit samples was performed using the Buxbaum model of positive rating. Fruit spirits produced from black currant cultivars displayed the highest contents of methanol (267.2-595.0 g/hl A.A.) and amyl alcohols (74.2-204.8 g/hl A.A.). Total sensory scores of currant brandies ranged between 17.60 and 18.40, while currant brandy produced from the Ben Sarek black currant cultivar received the highest score (18.40). All tested samples of currant brandies fulfilled EU requirements as regards their content of methanol and other components such as acetaldehyde, ethyl acetate, and high alcohols. The currant distillates were compared with other commercial spirits, including plum and grape brandies.
PB  - Soc Chemists Technologists Madeconia, Skopje
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Chemical and Sensorial Characteristics of Fruit Spirits Produced from  Different Black Currant (Ribes Nigrum L.) and Red Currant (Ribes Rubrum L.) Cultivars
VL  - 31
IS  - 2
SP  - 217
EP  - 227
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1580
ER  - 

@article{
author = "Vulic, Todor and Nikićević, Ninoslav and Stanković, Ljubisa and Veličković, Milovan and Todosijević, Marina and Popovic, Branko and Urosevic, Ivan and Stanković, Miroslava and Beraha, Isidora and Tešević, Vele",
year = "2012",
abstract = "The chemical characteristics of fruit spirits produced from three black currant cultivars (Mailing Juel, Ometa and Ben Sarek) and two red currant cultivars (Rondom and Versailles) grown in Serbia were examined using gas chromatography. In addition, a sensory evaluation of the spirit samples was performed using the Buxbaum model of positive rating. Fruit spirits produced from black currant cultivars displayed the highest contents of methanol (267.2-595.0 g/hl A.A.) and amyl alcohols (74.2-204.8 g/hl A.A.). Total sensory scores of currant brandies ranged between 17.60 and 18.40, while currant brandy produced from the Ben Sarek black currant cultivar received the highest score (18.40). All tested samples of currant brandies fulfilled EU requirements as regards their content of methanol and other components such as acetaldehyde, ethyl acetate, and high alcohols. The currant distillates were compared with other commercial spirits, including plum and grape brandies.",
publisher = "Soc Chemists Technologists Madeconia, Skopje",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Chemical and Sensorial Characteristics of Fruit Spirits Produced from  Different Black Currant (Ribes Nigrum L.) and Red Currant (Ribes Rubrum L.) Cultivars",
volume = "31",
number = "2",
pages = "217-227",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1580"
}

Vulic, T., Nikićević, N., Stanković, L., Veličković, M., Todosijević, M., Popovic, B., Urosevic, I., Stanković, M., Beraha, I.,& Tešević, V.. (2012). Chemical and Sensorial Characteristics of Fruit Spirits Produced from  Different Black Currant (Ribes Nigrum L.) and Red Currant (Ribes Rubrum L.) Cultivars. in Macedonian Journal of Chemistry and Chemical Engineering
Soc Chemists Technologists Madeconia, Skopje., 31(2), 217-227.
https://hdl.handle.net/21.15107/rcub_cherry_1580

Vulic T, Nikićević N, Stanković L, Veličković M, Todosijević M, Popovic B, Urosevic I, Stanković M, Beraha I, Tešević V. Chemical and Sensorial Characteristics of Fruit Spirits Produced from  Different Black Currant (Ribes Nigrum L.) and Red Currant (Ribes Rubrum L.) Cultivars. in Macedonian Journal of Chemistry and Chemical Engineering. 2012;31(2):217-227.
https://hdl.handle.net/21.15107/rcub_cherry_1580 .

Vulic, Todor, Nikićević, Ninoslav, Stanković, Ljubisa, Veličković, Milovan, Todosijević, Marina, Popovic, Branko, Urosevic, Ivan, Stanković, Miroslava, Beraha, Isidora, Tešević, Vele, "Chemical and Sensorial Characteristics of Fruit Spirits Produced from  Different Black Currant (Ribes Nigrum L.) and Red Currant (Ribes Rubrum L.) Cultivars" in Macedonian Journal of Chemistry and Chemical Engineering, 31, no. 2 (2012):217-227,
https://hdl.handle.net/21.15107/rcub_cherry_1580 .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Zdunić, Gordana
AU  - Ordevic, Boban
AU  - Stanković, Miroslava
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1315
AB  - On the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Food Science
T1  - Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA
VL  - 77
IS  - 7
DO  - 10.1111/j.1750-3841.2012.02756.x
ER  - 

@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M. and Zdunić, Gordana and Ordevic, Boban and Stanković, Miroslava",
year = "2012",
abstract = "On the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Food Science",
title = "Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA",
volume = "77",
number = "7",
doi = "10.1111/j.1750-3841.2012.02756.x"
}

Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S. M., Zdunić, G., Ordevic, B.,& Stanković, M.. (2012). Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA. in Journal of Food Science
Wiley-Blackwell, Hoboken., 77(7).
https://doi.org/10.1111/j.1750-3841.2012.02756.x

Gođevac D, Tešević V, Vajs V, Milosavljević SM, Zdunić G, Ordevic B, Stanković M. Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA. in Journal of Food Science. 2012;77(7).
doi:10.1111/j.1750-3841.2012.02756.x .

Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., Zdunić, Gordana, Ordevic, Boban, Stanković, Miroslava, "Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA" in Journal of Food Science, 77, no. 7 (2012),
https://doi.org/10.1111/j.1750-3841.2012.02756.x . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Stanković, Miroslava
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1199
AB  - The tentative identification of seed extracts from 3 cultivars of blackberry (blackberry seed extracts [BSEs]) constituents was performed by LC/UV/MS technique. The identified compounds belonged to ellagitannins, galic acid derivatives, and ellagic acid derivatives. Two ellagitannins, Lambertianin C and Sanguiniin H-6, and an ellagic acid derivative, 4-alpha-L-arabinofuranosylellagic acid, were isolated using semipreparative High-performance liquid chromatography. The structure elucidations were based on high resolution-mass spectrometry and nuclear magnetic resonance studies. The BSEs and 3 isolated pure compounds were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (MN) assay. The frequency of MN was scored in binucleated cells, and nuclear proliferation index was calculated. Among the tested extracts, the seeds of cv. Thornfree at concentration of 1 mu g/mL exhibit the most prominent effect decreasing the frequency of MN by 62.4%, when compared with the controls cell cultures. Antioxidant potential of pure ellagitannins cannot explain the strong effect of BSEs. The assumption was that better antioxidant effect of BSEs result from synergistic effects of individual compounds contained in the extracts and/or some minor components possessed strong activity.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Food Science
T1  - Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA
VL  - 76
IS  - 7
DO  - 10.1111/j.1750-3841.2011.02305.x
ER  - 

@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M. and Stanković, Miroslava",
year = "2011",
abstract = "The tentative identification of seed extracts from 3 cultivars of blackberry (blackberry seed extracts [BSEs]) constituents was performed by LC/UV/MS technique. The identified compounds belonged to ellagitannins, galic acid derivatives, and ellagic acid derivatives. Two ellagitannins, Lambertianin C and Sanguiniin H-6, and an ellagic acid derivative, 4-alpha-L-arabinofuranosylellagic acid, were isolated using semipreparative High-performance liquid chromatography. The structure elucidations were based on high resolution-mass spectrometry and nuclear magnetic resonance studies. The BSEs and 3 isolated pure compounds were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (MN) assay. The frequency of MN was scored in binucleated cells, and nuclear proliferation index was calculated. Among the tested extracts, the seeds of cv. Thornfree at concentration of 1 mu g/mL exhibit the most prominent effect decreasing the frequency of MN by 62.4%, when compared with the controls cell cultures. Antioxidant potential of pure ellagitannins cannot explain the strong effect of BSEs. The assumption was that better antioxidant effect of BSEs result from synergistic effects of individual compounds contained in the extracts and/or some minor components possessed strong activity.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Food Science",
title = "Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA",
volume = "76",
number = "7",
doi = "10.1111/j.1750-3841.2011.02305.x"
}

Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S. M.,& Stanković, M.. (2011). Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA. in Journal of Food Science
Wiley-Blackwell, Hoboken., 76(7).
https://doi.org/10.1111/j.1750-3841.2011.02305.x

Gođevac D, Tešević V, Vajs V, Milosavljević SM, Stanković M. Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA. in Journal of Food Science. 2011;76(7).
doi:10.1111/j.1750-3841.2011.02305.x .

Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., Stanković, Miroslava, "Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA" in Journal of Food Science, 76, no. 7 (2011),
https://doi.org/10.1111/j.1750-3841.2011.02305.x . .

TY  - JOUR
AU  - Nikićević, Ninoslav
AU  - Veličković, Milovan
AU  - Jadranin, Milka
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Vujisić, Ljubodrag V.
AU  - Stanković, Miroslava
AU  - Urosevic, Ivan
AU  - Tešević, Vele
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1206
AB  - The chemical and sensorial characteristics of cherry brandy produced from five cherry varieties (Oblacinska, Celery's 16, Rexle, Heiman's Ruby and Heiman's Conserve) grown in Serbia were studied. Gas chromatography and gas chromatography-mass spectrometry analysis of these distillates led to the identification of 32 components, including 20 esters, benzaldehyde, 6 terpenes and 5 acids. The ethyl esters of C(8)-C(18) acids were the most abundant in all samples. The benzaldehyde content was quantified by high performance liquid chromatography with UV detection. The average benzaldehyde concentration in the samples ranged between 2.1 and 24.1 mg L(-1). The total sensory scores of the cherry brandies ranged between 17.30 to 18.05, with the cherry brandy produced from the Celery's 16 variety receiving the highest score (18.05).
AB  - Ispitivane su hemijske i senzorske karakteristike rakije višnjevače proizvedene iz pet varijeteta višnje (Oblačinska, Celery's 16, Rexle, Heiman's Ruby i Heiman's Conserve) gajenih u Srbiji. Metodama gasne hromatografije i kombinacijom gasne hromatografije i masene spektrometrije u ekstrakatima identifikovana su 32 jedinjenja, 20 estara, benzaldehid, 6 terpena i 5 kiselina. Etil-estri C8-C18 kiselina su najobilniji u svim uzorcima. Sadržaj benzaldehida je određivan metodom tečne hromatografije uz UV detekciju. Prosečna količina benzaldehida u ispitivanim uzorcima bila je između 2,1 i 24,1 mg L-1. Ocene senzorskog ispitivanja rakija višnjevača su u rasponu od 17,30 do 18,05, dok je najbolje ocenjena (18,05) rakija proizvedena od varijeteta Celery's 16.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - The effects of the cherry variety on the chemical and sensorial characteristics of cherry brandy
T1  - Uticaj varijeteta višnje na hemijske i senzorne karakteristike rakije višnjevače
VL  - 76
IS  - 9
SP  - 1219
EP  - 1228
DO  - 10.2298/JSC101201109N
ER  - 

@article{
author = "Nikićević, Ninoslav and Veličković, Milovan and Jadranin, Milka and Vučković, Ivan M. and Novaković, Miroslav M. and Vujisić, Ljubodrag V. and Stanković, Miroslava and Urosevic, Ivan and Tešević, Vele",
year = "2011",
abstract = "The chemical and sensorial characteristics of cherry brandy produced from five cherry varieties (Oblacinska, Celery's 16, Rexle, Heiman's Ruby and Heiman's Conserve) grown in Serbia were studied. Gas chromatography and gas chromatography-mass spectrometry analysis of these distillates led to the identification of 32 components, including 20 esters, benzaldehyde, 6 terpenes and 5 acids. The ethyl esters of C(8)-C(18) acids were the most abundant in all samples. The benzaldehyde content was quantified by high performance liquid chromatography with UV detection. The average benzaldehyde concentration in the samples ranged between 2.1 and 24.1 mg L(-1). The total sensory scores of the cherry brandies ranged between 17.30 to 18.05, with the cherry brandy produced from the Celery's 16 variety receiving the highest score (18.05)., Ispitivane su hemijske i senzorske karakteristike rakije višnjevače proizvedene iz pet varijeteta višnje (Oblačinska, Celery's 16, Rexle, Heiman's Ruby i Heiman's Conserve) gajenih u Srbiji. Metodama gasne hromatografije i kombinacijom gasne hromatografije i masene spektrometrije u ekstrakatima identifikovana su 32 jedinjenja, 20 estara, benzaldehid, 6 terpena i 5 kiselina. Etil-estri C8-C18 kiselina su najobilniji u svim uzorcima. Sadržaj benzaldehida je određivan metodom tečne hromatografije uz UV detekciju. Prosečna količina benzaldehida u ispitivanim uzorcima bila je između 2,1 i 24,1 mg L-1. Ocene senzorskog ispitivanja rakija višnjevača su u rasponu od 17,30 do 18,05, dok je najbolje ocenjena (18,05) rakija proizvedena od varijeteta Celery's 16.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "The effects of the cherry variety on the chemical and sensorial characteristics of cherry brandy, Uticaj varijeteta višnje na hemijske i senzorne karakteristike rakije višnjevače",
volume = "76",
number = "9",
pages = "1219-1228",
doi = "10.2298/JSC101201109N"
}

Nikićević, N., Veličković, M., Jadranin, M., Vučković, I. M., Novaković, M. M., Vujisić, L. V., Stanković, M., Urosevic, I.,& Tešević, V.. (2011). The effects of the cherry variety on the chemical and sensorial characteristics of cherry brandy. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 76(9), 1219-1228.
https://doi.org/10.2298/JSC101201109N

Nikićević N, Veličković M, Jadranin M, Vučković IM, Novaković MM, Vujisić LV, Stanković M, Urosevic I, Tešević V. The effects of the cherry variety on the chemical and sensorial characteristics of cherry brandy. in Journal of the Serbian Chemical Society. 2011;76(9):1219-1228.
doi:10.2298/JSC101201109N .

Nikićević, Ninoslav, Veličković, Milovan, Jadranin, Milka, Vučković, Ivan M., Novaković, Miroslav M., Vujisić, Ljubodrag V., Stanković, Miroslava, Urosevic, Ivan, Tešević, Vele, "The effects of the cherry variety on the chemical and sensorial characteristics of cherry brandy" in Journal of the Serbian Chemical Society, 76, no. 9 (2011):1219-1228,
https://doi.org/10.2298/JSC101201109N . .

TY  - JOUR
AU  - Vučković, Ivan M.
AU  - Vajs, Vlatka
AU  - Stanković, Miroslava
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1067
AB  - A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA
VL  - 7
IS  - 3
SP  - 698
EP  - 704
DO  - 10.1002/cbdv.200900067
ER  - 

@article{
author = "Vučković, Ivan M. and Vajs, Vlatka and Stanković, Miroslava and Tešević, Vele and Milosavljević, Slobodan M.",
year = "2010",
abstract = "A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA",
volume = "7",
number = "3",
pages = "698-704",
doi = "10.1002/cbdv.200900067"
}

Vučković, I. M., Vajs, V., Stanković, M., Tešević, V.,& Milosavljević, S. M.. (2010). A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 7(3), 698-704.
https://doi.org/10.1002/cbdv.200900067

Vučković IM, Vajs V, Stanković M, Tešević V, Milosavljević SM. A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity. 2010;7(3):698-704.
doi:10.1002/cbdv.200900067 .

Vučković, Ivan M., Vajs, Vlatka, Stanković, Miroslava, Tešević, Vele, Milosavljević, Slobodan M., "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA" in Chemistry and Biodiversity, 7, no. 3 (2010):698-704,
https://doi.org/10.1002/cbdv.200900067 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Stanković, Miroslava
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag V.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1079
AB  - This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species
VL  - 5
IS  - 5
SP  - 729
EP  - 732
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1079
ER  - 

@article{
author = "Aljančić, Ivana and Stanković, Miroslava and Tešević, Vele and Vujisić, Ljubodrag V. and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2010",
abstract = "This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species",
volume = "5",
number = "5",
pages = "729-732",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1079"
}

Aljančić, I., Stanković, M., Tešević, V., Vujisić, L. V., Vajs, V.,& Milosavljević, S. M.. (2010). Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species. in Natural Product Communications
Natural Products Inc, Westerville., 5(5), 729-732.
https://hdl.handle.net/21.15107/rcub_cherry_1079

Aljančić I, Stanković M, Tešević V, Vujisić LV, Vajs V, Milosavljević SM. Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species. in Natural Product Communications. 2010;5(5):729-732.
https://hdl.handle.net/21.15107/rcub_cherry_1079 .

Aljančić, Ivana, Stanković, Miroslava, Tešević, Vele, Vujisić, Ljubodrag V., Vajs, Vlatka, Milosavljević, Slobodan M., "Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species" in Natural Product Communications, 5, no. 5 (2010):729-732,
https://hdl.handle.net/21.15107/rcub_cherry_1079 .

TY  - JOUR
AU  - Tešević, Vele
AU  - Nikićević, Ninoslav
AU  - Milosavljević, Slobodan M.
AU  - Bajić, Danica
AU  - Vajs, Vlatka
AU  - Vučković, Ivan M.
AU  - Vujisić, Ljubodrag V.
AU  - Đorđević, Iris
AU  - Stanković, Miroslava
AU  - Veličković, Milovan
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/613
AB  - In this study, volatile compounds were analyzed in five samples of home-made spirit beverage made by the distillation of fermented fruits of cornelian cherry (Cornus mas L.). The major volatile compounds, besides ethanol, identified and quantified were: methanol, acetaldehyde, I-propanol, ethyl acetate, 2-methyl-1-propanol, 1-butanol, amyl alcohols, 1-hexanol and 2-phenyl-ethanol, The minor volatiles were submitted to liquid liquid extraction with dichloromethane and analyzed by gas chromatography and gas chromatography/ /mass spectrometry (GC/MS). A total of 84 compounds were identified. The most abundant compounds were straight-chain free fatty acids, ethyl esters of C(6)-C(18) acids, limonene, 2-phenylethanol and 4-ethylphenol. Most of the compounds found in the "Drenja" spirits investigated in this study arc similar to those present in other alcoholic beverages.
AB  - U radu su analizirane isparljive komponente u pet uzoraka alkoholnih pića, domaće izrade, dobijenih destilacijom fermentisanih plodova drenjine (Cornus mas L.). Glavna isparljiva jedinjenja, koja su određena i kvantifikovana, su: metanol, 1-propanol, etil-acetat, 2-metil-1-propanol, 1-butanol, izoamil-alkoholi, 1-heksanol i 2-feniletanol. Manje zastupljena isparljiva jedinjenja su ekstrahovana dihlormetanom i analizirana kombinacijom gasne hromatografije i masene spektrometrije (GC/MS). Identifikovana su ukupno 84 jedinjenja. Najzastupljenija jedinjenja bila su etil estri masnih kiselina sa C6-C18, slobodne masne kiseline, limonen, 2-feniletanol i 4-etilfenol. Većina jedinjenja nađena u 'drenji' su slična onima koja su prisutna i u drugim alkoholnim pićima.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Characterization of volatile compounds of "Drenja", an alcoholic beverage obtained from the fruits of cornelian cherry
T1  - Karakterizacija isparljivih komponenti 'Drenje', alkoholnog pića dobijenog iz plodova drenjine (Cornus mas)
VL  - 74
IS  - 2
SP  - 117
EP  - 128
DO  - 10.2298/JSC0902117T
ER  - 

@article{
author = "Tešević, Vele and Nikićević, Ninoslav and Milosavljević, Slobodan M. and Bajić, Danica and Vajs, Vlatka and Vučković, Ivan M. and Vujisić, Ljubodrag V. and Đorđević, Iris and Stanković, Miroslava and Veličković, Milovan",
year = "2009",
abstract = "In this study, volatile compounds were analyzed in five samples of home-made spirit beverage made by the distillation of fermented fruits of cornelian cherry (Cornus mas L.). The major volatile compounds, besides ethanol, identified and quantified were: methanol, acetaldehyde, I-propanol, ethyl acetate, 2-methyl-1-propanol, 1-butanol, amyl alcohols, 1-hexanol and 2-phenyl-ethanol, The minor volatiles were submitted to liquid liquid extraction with dichloromethane and analyzed by gas chromatography and gas chromatography/ /mass spectrometry (GC/MS). A total of 84 compounds were identified. The most abundant compounds were straight-chain free fatty acids, ethyl esters of C(6)-C(18) acids, limonene, 2-phenylethanol and 4-ethylphenol. Most of the compounds found in the "Drenja" spirits investigated in this study arc similar to those present in other alcoholic beverages., U radu su analizirane isparljive komponente u pet uzoraka alkoholnih pića, domaće izrade, dobijenih destilacijom fermentisanih plodova drenjine (Cornus mas L.). Glavna isparljiva jedinjenja, koja su određena i kvantifikovana, su: metanol, 1-propanol, etil-acetat, 2-metil-1-propanol, 1-butanol, izoamil-alkoholi, 1-heksanol i 2-feniletanol. Manje zastupljena isparljiva jedinjenja su ekstrahovana dihlormetanom i analizirana kombinacijom gasne hromatografije i masene spektrometrije (GC/MS). Identifikovana su ukupno 84 jedinjenja. Najzastupljenija jedinjenja bila su etil estri masnih kiselina sa C6-C18, slobodne masne kiseline, limonen, 2-feniletanol i 4-etilfenol. Većina jedinjenja nađena u 'drenji' su slična onima koja su prisutna i u drugim alkoholnim pićima.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Characterization of volatile compounds of "Drenja", an alcoholic beverage obtained from the fruits of cornelian cherry, Karakterizacija isparljivih komponenti 'Drenje', alkoholnog pića dobijenog iz plodova drenjine (Cornus mas)",
volume = "74",
number = "2",
pages = "117-128",
doi = "10.2298/JSC0902117T"
}

Tešević, V., Nikićević, N., Milosavljević, S. M., Bajić, D., Vajs, V., Vučković, I. M., Vujisić, L. V., Đorđević, I., Stanković, M.,& Veličković, M.. (2009). Characterization of volatile compounds of "Drenja", an alcoholic beverage obtained from the fruits of cornelian cherry. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 74(2), 117-128.
https://doi.org/10.2298/JSC0902117T

Tešević V, Nikićević N, Milosavljević SM, Bajić D, Vajs V, Vučković IM, Vujisić LV, Đorđević I, Stanković M, Veličković M. Characterization of volatile compounds of "Drenja", an alcoholic beverage obtained from the fruits of cornelian cherry. in Journal of the Serbian Chemical Society. 2009;74(2):117-128.
doi:10.2298/JSC0902117T .

Tešević, Vele, Nikićević, Ninoslav, Milosavljević, Slobodan M., Bajić, Danica, Vajs, Vlatka, Vučković, Ivan M., Vujisić, Ljubodrag V., Đorđević, Iris, Stanković, Miroslava, Veličković, Milovan, "Characterization of volatile compounds of "Drenja", an alcoholic beverage obtained from the fruits of cornelian cherry" in Journal of the Serbian Chemical Society, 74, no. 2 (2009):117-128,
https://doi.org/10.2298/JSC0902117T . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Stanković, Miroslava
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1029
AB  - This study addresses in vitro effects of raspberry (Rubus idaeus) seed extracts (RSE) on the frequency of micronuclei. We evaluated the effects of three different extracts (50%, 80%, and 100% methanol) in doses of 1.4, 4.2, and 8.4 mu g/mL, per 5 mL culture using cytochalasin-B micronucleus (CBMN) assay in peripheral human lymphocytes. The frequency of MN was scored in binucleated (BN) cells. The nuclear proliferation index was also calculated. The distribution of polyphenolic compounds in RSEs was determined using LC/UV/ESI-TOF MS. The identified 37 compounds comprised flavanol monomers and oligomers, as well as varieties of ellagitannin components. Treatment of lymphocytes with RSEs induced a significant decrease in the frequency of micronuclei by 80%. These results demonstrate that the constituents of RSEs may be important in the prevention of oxidative lymphocyte damage by reactive oxygen species and may also reduce the level of DNA damage. These findings support the potential benefits of polyphenolic compounds from raspberry seeds as efficient antioxidants. (C) 2009 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Antioxidant properties of raspberry seed extracts on micronucleus distribution in peripheral blood lymphocytes
VL  - 47
IS  - 11
SP  - 2853
EP  - 2859
DO  - 10.1016/j.fct.2009.09.006
ER  - 

@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M. and Stanković, Miroslava",
year = "2009",
abstract = "This study addresses in vitro effects of raspberry (Rubus idaeus) seed extracts (RSE) on the frequency of micronuclei. We evaluated the effects of three different extracts (50%, 80%, and 100% methanol) in doses of 1.4, 4.2, and 8.4 mu g/mL, per 5 mL culture using cytochalasin-B micronucleus (CBMN) assay in peripheral human lymphocytes. The frequency of MN was scored in binucleated (BN) cells. The nuclear proliferation index was also calculated. The distribution of polyphenolic compounds in RSEs was determined using LC/UV/ESI-TOF MS. The identified 37 compounds comprised flavanol monomers and oligomers, as well as varieties of ellagitannin components. Treatment of lymphocytes with RSEs induced a significant decrease in the frequency of micronuclei by 80%. These results demonstrate that the constituents of RSEs may be important in the prevention of oxidative lymphocyte damage by reactive oxygen species and may also reduce the level of DNA damage. These findings support the potential benefits of polyphenolic compounds from raspberry seeds as efficient antioxidants. (C) 2009 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Antioxidant properties of raspberry seed extracts on micronucleus distribution in peripheral blood lymphocytes",
volume = "47",
number = "11",
pages = "2853-2859",
doi = "10.1016/j.fct.2009.09.006"
}

Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S. M.,& Stanković, M.. (2009). Antioxidant properties of raspberry seed extracts on micronucleus distribution in peripheral blood lymphocytes. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 47(11), 2853-2859.
https://doi.org/10.1016/j.fct.2009.09.006

Gođevac D, Tešević V, Vajs V, Milosavljević SM, Stanković M. Antioxidant properties of raspberry seed extracts on micronucleus distribution in peripheral blood lymphocytes. in Food and Chemical Toxicology. 2009;47(11):2853-2859.
doi:10.1016/j.fct.2009.09.006 .

Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., Stanković, Miroslava, "Antioxidant properties of raspberry seed extracts on micronucleus distribution in peripheral blood lymphocytes" in Food and Chemical Toxicology, 47, no. 11 (2009):2853-2859,
https://doi.org/10.1016/j.fct.2009.09.006 . .

TY  - JOUR
AU  - Stanković, Miroslava
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Todorović, Nina
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/952
AB  - The distribution of polyphenolic compounds in a grape (Vitis vinifera) seed extract (GSE) was determined using LC/ESI-TOF MS, HPLC/DAD, and (13)C-NMR. The 17 identified compounds comprised gallic and protocatechuic acid, catetchin and epicatechin monomers, procyanidin oligomers, and procyanidin gallates. This study addresses the in vitro effects of grape seed extract (GSE) on the frequency of micronuclei with reference to the antioxidant status in human lymphocytes. To establish the most effective protective support, we used four different concentrations of GSE, in the range 1-6 mu g/mL. Treatment of lymphocytes with GSE at a concentration of 2.5 mu g/mL induced a significant decrease in the frequency of micronuclei by 40%, reduction of malonyldialdehyde production by 30%, while a concentration of 5 mu g/mL increased catalase and glutathione S-transferase activity by 10 % and 15 %, respectively. These results demonstrate that GSE may be effective in the prevention of oxidative lymphocyte damage by ROS.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Antioxidant properties of grape seed extract on human lymphocyte oxidative defence
VL  - 74
IS  - 7
SP  - 730
EP  - 735
DO  - 10.1055/s-2008-1074521
ER  - 

@article{
author = "Stanković, Miroslava and Tešević, Vele and Vajs, Vlatka and Todorović, Nina and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2008",
abstract = "The distribution of polyphenolic compounds in a grape (Vitis vinifera) seed extract (GSE) was determined using LC/ESI-TOF MS, HPLC/DAD, and (13)C-NMR. The 17 identified compounds comprised gallic and protocatechuic acid, catetchin and epicatechin monomers, procyanidin oligomers, and procyanidin gallates. This study addresses the in vitro effects of grape seed extract (GSE) on the frequency of micronuclei with reference to the antioxidant status in human lymphocytes. To establish the most effective protective support, we used four different concentrations of GSE, in the range 1-6 mu g/mL. Treatment of lymphocytes with GSE at a concentration of 2.5 mu g/mL induced a significant decrease in the frequency of micronuclei by 40%, reduction of malonyldialdehyde production by 30%, while a concentration of 5 mu g/mL increased catalase and glutathione S-transferase activity by 10 % and 15 %, respectively. These results demonstrate that GSE may be effective in the prevention of oxidative lymphocyte damage by ROS.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Antioxidant properties of grape seed extract on human lymphocyte oxidative defence",
volume = "74",
number = "7",
pages = "730-735",
doi = "10.1055/s-2008-1074521"
}

Stanković, M., Tešević, V., Vajs, V., Todorović, N., Milosavljević, S. M.,& Gođevac, D.. (2008). Antioxidant properties of grape seed extract on human lymphocyte oxidative defence. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 74(7), 730-735.
https://doi.org/10.1055/s-2008-1074521

Stanković M, Tešević V, Vajs V, Todorović N, Milosavljević SM, Gođevac D. Antioxidant properties of grape seed extract on human lymphocyte oxidative defence. in Planta Medica. 2008;74(7):730-735.
doi:10.1055/s-2008-1074521 .

Stanković, Miroslava, Tešević, Vele, Vajs, Vlatka, Todorović, Nina, Milosavljević, Slobodan M., Gođevac, Dejan, "Antioxidant properties of grape seed extract on human lymphocyte oxidative defence" in Planta Medica, 74, no. 7 (2008):730-735,
https://doi.org/10.1055/s-2008-1074521 . .