TY  - JOUR
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Kiewiet, Mensiena B. Gea
AU  - Peruško, Marija
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Paulie, Staffan
AU  - Hage, Marianne van
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6244
AB  - Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and α-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing α-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the α-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to α-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.
PB  - American Society for Clinical Investigation
T2  - The Journal of Clinical Investigation
T1  - Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome
VL  - 133
IS  - 6
DO  - 10.1172/JCI158357
ER  - 

@article{
author = "Apostolović, Danijela and Grundström, Jeanette and Kiewiet, Mensiena B. Gea and Peruško, Marija and Hamsten, Carl and Starkhammar, Maria and Paulie, Staffan and Hage, Marianne van",
year = "2023",
abstract = "Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and α-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing α-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the α-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to α-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.",
publisher = "American Society for Clinical Investigation",
journal = "The Journal of Clinical Investigation",
title = "Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome",
volume = "133",
number = "6",
doi = "10.1172/JCI158357"
}

Apostolović, D., Grundström, J., Kiewiet, M. B. G., Peruško, M., Hamsten, C., Starkhammar, M., Paulie, S.,& Hage, M. v.. (2023). Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. in The Journal of Clinical Investigation
American Society for Clinical Investigation., 133(6).
https://doi.org/10.1172/JCI158357

Apostolović D, Grundström J, Kiewiet MBG, Peruško M, Hamsten C, Starkhammar M, Paulie S, Hage MV. Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. in The Journal of Clinical Investigation. 2023;133(6).
doi:10.1172/JCI158357 .

Apostolović, Danijela, Grundström, Jeanette, Kiewiet, Mensiena B. Gea, Peruško, Marija, Hamsten, Carl, Starkhammar, Maria, Paulie, Staffan, Hage, Marianne van, "Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome" in The Journal of Clinical Investigation, 133, no. 6 (2023),
https://doi.org/10.1172/JCI158357 . .

TY  - DATA
AU  - Peruško, Marija
AU  - Apostolović, Danijela
AU  - Kiewiet, Mensiena Berentje Geertje
AU  - Grundström, Jeanette
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - Hage, Marianne van
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4447
PB  - Blackwell Publishing Ltd
T2  - Allergy
T2  - Allergy
T1  - Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4447
ER  - 

@misc{
author = "Peruško, Marija and Apostolović, Danijela and Kiewiet, Mensiena Berentje Geertje and Grundström, Jeanette and Hamsten, Carl and Starkhammar, Maria and Ćirković-Veličković, Tanja and Hage, Marianne van",
year = "2021",
publisher = "Blackwell Publishing Ltd",
journal = "Allergy, Allergy",
title = "Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4447"
}

Peruško, M., Apostolović, D., Kiewiet, M. B. G., Grundström, J., Hamsten, C., Starkhammar, M., Ćirković-Veličković, T.,& Hage, M. v.. (2021). Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.. in Allergy
Blackwell Publishing Ltd..
https://hdl.handle.net/21.15107/rcub_cherry_4447

Peruško M, Apostolović D, Kiewiet MBG, Grundström J, Hamsten C, Starkhammar M, Ćirković-Veličković T, Hage MV. Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889.. in Allergy. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4447 .

Peruško, Marija, Apostolović, Danijela, Kiewiet, Mensiena Berentje Geertje, Grundström, Jeanette, Hamsten, Carl, Starkhammar, Maria, Ćirković-Veličković, Tanja, Hage, Marianne van, "Supplementary data for the article: Perusko, M.; Apostolovic, D.; Kiewiet, M. B. G.; Grundström, J.; Hamsten, C.; Starkhammar, M.; Velickovic, T. C.; Hage, M. van. Bovine γ-Globulin, Lactoferrin, and Lactoperoxidase Are Relevant Bovine Milk Allergens in Patients with α-Gal Syndrome. Allergy n/a (n/a). https://doi.org/10.1111/all.14889." in Allergy (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4447 .

TY  - JOUR
AU  - Peruško, Marija
AU  - Apostolović, Danijela
AU  - Kiewiet, Mensiena Berentje Geertje
AU  - Grundström, Jeanette
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - Hage, Marianne van
PY  - 2021
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/all.14889
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4446
AB  - Background Mammalian meat is the most common trigger of the allergic reactions in patients with α-Gal syndrome (AGS). Milk and dairy, although less often, also cause a significant number of allergic manifestations. The aim of this study was to identify α-Gal-containing bovine milk proteins with allergenic properties among AGS patients. Methods Thirty-eight AGS patients with IgE to milk were included in the study. Milk proteins were analyzed for the presence of α-Gal and for binding by patients’ IgE using immunoblot, ImmunoCAP, and inhibition ELISA. Allergenicity of milk and milk proteins was assessed by basophil activation test. Results More than half of the AGS patients reported allergic reactions to milk or dairy products. Bovine γ-globulin (BGG), lactoferrin (LF), and lactoperoxidase (LPO) were identified as α-Gal carrying proteins which were recognized by AGS patients’ IgE. Whey mirrored the anti-α-Gal and IgE reactivity of BGG, LF, and LPO. Eighty-nine percent of the patients displayed IgE to BGG, 91% to LF, and 57% to LPO. Inhibition of α-Gal-specific IgE binding was achieved by BGG, LF, LPO, and whey. These proteins also activated AGS patients’ basophils. Interestingly, at lower concentrations, LF was the most potent inhibitor of IgE binding, and the most potent activator of basophils. Conclusion BGG, LF, and LPO were all found to be relevant milk α-Gal-containing glycoproteins that bound AGS patients’ IgE antibodies and activated their basophils. These proteins are probably involved in the allergic reactions to milk in AGS patients. LPO was for the first time shown to be an allergen.
PB  - Wiley
T2  - Allergy
T2  - Allergy
T1  - Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome
VL  - 76
IS  - 12
SP  - 3766
EP  - 3775
DO  - 10.1111/all.14889
ER  - 

@article{
author = "Peruško, Marija and Apostolović, Danijela and Kiewiet, Mensiena Berentje Geertje and Grundström, Jeanette and Hamsten, Carl and Starkhammar, Maria and Ćirković-Veličković, Tanja and Hage, Marianne van",
year = "2021",
abstract = "Background Mammalian meat is the most common trigger of the allergic reactions in patients with α-Gal syndrome (AGS). Milk and dairy, although less often, also cause a significant number of allergic manifestations. The aim of this study was to identify α-Gal-containing bovine milk proteins with allergenic properties among AGS patients. Methods Thirty-eight AGS patients with IgE to milk were included in the study. Milk proteins were analyzed for the presence of α-Gal and for binding by patients’ IgE using immunoblot, ImmunoCAP, and inhibition ELISA. Allergenicity of milk and milk proteins was assessed by basophil activation test. Results More than half of the AGS patients reported allergic reactions to milk or dairy products. Bovine γ-globulin (BGG), lactoferrin (LF), and lactoperoxidase (LPO) were identified as α-Gal carrying proteins which were recognized by AGS patients’ IgE. Whey mirrored the anti-α-Gal and IgE reactivity of BGG, LF, and LPO. Eighty-nine percent of the patients displayed IgE to BGG, 91% to LF, and 57% to LPO. Inhibition of α-Gal-specific IgE binding was achieved by BGG, LF, LPO, and whey. These proteins also activated AGS patients’ basophils. Interestingly, at lower concentrations, LF was the most potent inhibitor of IgE binding, and the most potent activator of basophils. Conclusion BGG, LF, and LPO were all found to be relevant milk α-Gal-containing glycoproteins that bound AGS patients’ IgE antibodies and activated their basophils. These proteins are probably involved in the allergic reactions to milk in AGS patients. LPO was for the first time shown to be an allergen.",
publisher = "Wiley",
journal = "Allergy, Allergy",
title = "Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome",
volume = "76",
number = "12",
pages = "3766-3775",
doi = "10.1111/all.14889"
}

Peruško, M., Apostolović, D., Kiewiet, M. B. G., Grundström, J., Hamsten, C., Starkhammar, M., Ćirković-Veličković, T.,& Hage, M. v.. (2021). Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome. in Allergy
Wiley., 76(12), 3766-3775.
https://doi.org/10.1111/all.14889

Peruško M, Apostolović D, Kiewiet MBG, Grundström J, Hamsten C, Starkhammar M, Ćirković-Veličković T, Hage MV. Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome. in Allergy. 2021;76(12):3766-3775.
doi:10.1111/all.14889 .

Peruško, Marija, Apostolović, Danijela, Kiewiet, Mensiena Berentje Geertje, Grundström, Jeanette, Hamsten, Carl, Starkhammar, Maria, Ćirković-Veličković, Tanja, Hage, Marianne van, "Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome" in Allergy, 76, no. 12 (2021):3766-3775,
https://doi.org/10.1111/all.14889 . .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Peruško, Marija
AU  - Kiewiet, M. B. Gea
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - van Hage, Marianne
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4839
PB  - Wiley
T2  - Clinical and Translational Allergy
T2  - Clinical and Translational AllergyClin Transl Allergy
T1  - Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients
VL  - 11
IS  - 10
SP  - e12087
DO  - 10.1002/clt2.12087
ER  - 

@article{
author = "Apostolović, Danijela and Grundström, Jeanette and Peruško, Marija and Kiewiet, M. B. Gea and Hamsten, Carl and Starkhammar, Maria and van Hage, Marianne",
year = "2021",
publisher = "Wiley",
journal = "Clinical and Translational Allergy, Clinical and Translational AllergyClin Transl Allergy",
title = "Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients",
volume = "11",
number = "10",
pages = "e12087",
doi = "10.1002/clt2.12087"
}

Apostolović, D., Grundström, J., Peruško, M., Kiewiet, M. B. G., Hamsten, C., Starkhammar, M.,& van Hage, M.. (2021). Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients. in Clinical and Translational Allergy
Wiley., 11(10), e12087.
https://doi.org/10.1002/clt2.12087

Apostolović D, Grundström J, Peruško M, Kiewiet MBG, Hamsten C, Starkhammar M, van Hage M. Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients. in Clinical and Translational Allergy. 2021;11(10):e12087.
doi:10.1002/clt2.12087 .

Apostolović, Danijela, Grundström, Jeanette, Peruško, Marija, Kiewiet, M. B. Gea, Hamsten, Carl, Starkhammar, Maria, van Hage, Marianne, "Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients" in Clinical and Translational Allergy, 11, no. 10 (2021):e12087,
https://doi.org/10.1002/clt2.12087 . .

TY  - JOUR
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Apostolović, Danijela
AU  - Radomirović, Mirjana Ž.
AU  - Jovanović, Vesna B.
AU  - Radoi, Vlad
AU  - Kiewiet, M. B. Gea
AU  - Vukojević, Vladana
AU  - Ćirković-Veličković, Tanja
AU  - van Hage, Marianne
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4866
AB  - Transepithelial transport of proteins is an important step in the immune response to food allergens. Mammalian meat allergy is characterized by an IgE response against the carbohydrate moiety galactosyl-α-1,3-galactose (α-Gal) present on mammalian glycoproteins and glycolipids, which causes severe allergic reactions several hours after red meat consumption. The delayed reaction may be related to the processing of α-Gal carrying proteins in the gastrointestinal tract. The aim of this study was to investigate how protein glycosylation by α-Gal affects the susceptibility to gastric digestion and transport through the Caco-2 cell monolayer. We found that α-Gal glycosylation altered protein susceptibility to gastric digestion, where large protein fragments bearing the α-Gal epitope remained for up to 2 h of digestion. Furthermore, α-Gal glycosylation of the protein hampered transcytosis of the protein through the Caco-2 monolayer. α-Gal epitope on the intact protein could be detected in the endosomal fraction obtained by differential centrifugation of Caco-2 cell lysates. Furthermore, the level of galectin-3 in Caco-2 cells was not affected by the presence of α-Gal glycosylated BSA (bovine serum albumin) (BSA-α-Gal). Taken together, our data add new knowledge and shed light on the digestion and transport of α-Gal glycosylated proteins.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer
VL  - 21
IS  - 16
SP  - 5742
DO  - 10.3390/ijms21165742
ER  - 

@article{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Apostolović, Danijela and Radomirović, Mirjana Ž. and Jovanović, Vesna B. and Radoi, Vlad and Kiewiet, M. B. Gea and Vukojević, Vladana and Ćirković-Veličković, Tanja and van Hage, Marianne",
year = "2020",
abstract = "Transepithelial transport of proteins is an important step in the immune response to food allergens. Mammalian meat allergy is characterized by an IgE response against the carbohydrate moiety galactosyl-α-1,3-galactose (α-Gal) present on mammalian glycoproteins and glycolipids, which causes severe allergic reactions several hours after red meat consumption. The delayed reaction may be related to the processing of α-Gal carrying proteins in the gastrointestinal tract. The aim of this study was to investigate how protein glycosylation by α-Gal affects the susceptibility to gastric digestion and transport through the Caco-2 cell monolayer. We found that α-Gal glycosylation altered protein susceptibility to gastric digestion, where large protein fragments bearing the α-Gal epitope remained for up to 2 h of digestion. Furthermore, α-Gal glycosylation of the protein hampered transcytosis of the protein through the Caco-2 monolayer. α-Gal epitope on the intact protein could be detected in the endosomal fraction obtained by differential centrifugation of Caco-2 cell lysates. Furthermore, the level of galectin-3 in Caco-2 cells was not affected by the presence of α-Gal glycosylated BSA (bovine serum albumin) (BSA-α-Gal). Taken together, our data add new knowledge and shed light on the digestion and transport of α-Gal glycosylated proteins.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer",
volume = "21",
number = "16",
pages = "5742",
doi = "10.3390/ijms21165742"
}

Krstić-Ristivojević, M., Grundström, J., Apostolović, D., Radomirović, M. Ž., Jovanović, V. B., Radoi, V., Kiewiet, M. B. G., Vukojević, V., Ćirković-Veličković, T.,& van Hage, M.. (2020). Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer. in International Journal of Molecular Sciences
MDPI., 21(16), 5742.
https://doi.org/10.3390/ijms21165742

Krstić-Ristivojević M, Grundström J, Apostolović D, Radomirović MŽ, Jovanović VB, Radoi V, Kiewiet MBG, Vukojević V, Ćirković-Veličković T, van Hage M. Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer. in International Journal of Molecular Sciences. 2020;21(16):5742.
doi:10.3390/ijms21165742 .

Krstić-Ristivojević, Maja, Grundström, Jeanette, Apostolović, Danijela, Radomirović, Mirjana Ž., Jovanović, Vesna B., Radoi, Vlad, Kiewiet, M. B. Gea, Vukojević, Vladana, Ćirković-Veličković, Tanja, van Hage, Marianne, "Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer" in International Journal of Molecular Sciences, 21, no. 16 (2020):5742,
https://doi.org/10.3390/ijms21165742 . .

TY  - DATA
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Radoi, Vlad
AU  - Starkhammar, Maria
AU  - Vukojević, Vesna
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3073
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3073
ER  - 

@misc{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Tran, Thi Anh Thu and Apostolović, Danijela and Radoi, Vlad and Starkhammar, Maria and Vukojević, Vesna and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2018",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3073"
}

Krstić-Ristivojević, M., Grundström, J., Tran, T. A. T., Apostolović, D., Radoi, V., Starkhammar, M., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2018). Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8. in Scientific Reports
Nature Publishing Group, London..
https://hdl.handle.net/21.15107/rcub_cherry_3073

Krstić-Ristivojević M, Grundström J, Tran TAT, Apostolović D, Radoi V, Starkhammar M, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8. in Scientific Reports. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3073 .

Krstić-Ristivojević, Maja, Grundström, Jeanette, Tran, Thi Anh Thu, Apostolović, Danijela, Radoi, Vlad, Starkhammar, Maria, Vukojević, Vesna, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8" in Scientific Reports (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3073 .

TY  - JOUR
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Radoi, Vlad
AU  - Starkhammar, Maria
AU  - Vukojević, Vladana
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2207
AB  - Red meat allergy is characterized by an IgE response against the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how alpha-Gal is processed and presented to the immune system to initiate an allergic reaction are still unknown. The aim of this study was to reveal whether the presence of alpha-Gal epitopes on the protein surface influence antigen uptake and processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared from healthy blood donors and red meat allergic patients. We found an increased internalization of alpha-Gal carrying proteins over time in iMDDCs by flow cytometric analysis, which was independent of the donor allergic status. The uptake of alpha-Gal carrying proteins was significantly higher than the uptake of non-alpha-Gal carrying proteins. Confocal microscopy revealed alpha-Gal carrying proteins scattered around the cytoplasm in most iMDDCs while detection of proteins not carrying alpha-Gal was negligible. Fluorescent detection of protein on SDS-PAGE showed that degradation of alpha-Gal carrying proteins was slower than degradation of non-alpha-Gal carrying proteins. Thus, the presence of alpha-Gal on the protein surface affects both uptake and degradation of the protein, and the results add new knowledge of alpha-Gal as a clinically relevant food allergen.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells
VL  - 8
DO  - 10.1038/s41598-018-30887-8
ER  - 

@article{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Tran, Thi Anh Thu and Apostolović, Danijela and Radoi, Vlad and Starkhammar, Maria and Vukojević, Vladana and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2018",
abstract = "Red meat allergy is characterized by an IgE response against the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how alpha-Gal is processed and presented to the immune system to initiate an allergic reaction are still unknown. The aim of this study was to reveal whether the presence of alpha-Gal epitopes on the protein surface influence antigen uptake and processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared from healthy blood donors and red meat allergic patients. We found an increased internalization of alpha-Gal carrying proteins over time in iMDDCs by flow cytometric analysis, which was independent of the donor allergic status. The uptake of alpha-Gal carrying proteins was significantly higher than the uptake of non-alpha-Gal carrying proteins. Confocal microscopy revealed alpha-Gal carrying proteins scattered around the cytoplasm in most iMDDCs while detection of proteins not carrying alpha-Gal was negligible. Fluorescent detection of protein on SDS-PAGE showed that degradation of alpha-Gal carrying proteins was slower than degradation of non-alpha-Gal carrying proteins. Thus, the presence of alpha-Gal on the protein surface affects both uptake and degradation of the protein, and the results add new knowledge of alpha-Gal as a clinically relevant food allergen.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells",
volume = "8",
doi = "10.1038/s41598-018-30887-8"
}

Krstić-Ristivojević, M., Grundström, J., Tran, T. A. T., Apostolović, D., Radoi, V., Starkhammar, M., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2018). alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells. in Scientific Reports
Nature Publishing Group, London., 8.
https://doi.org/10.1038/s41598-018-30887-8

Krstić-Ristivojević M, Grundström J, Tran TAT, Apostolović D, Radoi V, Starkhammar M, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells. in Scientific Reports. 2018;8.
doi:10.1038/s41598-018-30887-8 .

Krstić-Ristivojević, Maja, Grundström, Jeanette, Tran, Thi Anh Thu, Apostolović, Danijela, Radoi, Vlad, Starkhammar, Maria, Vukojević, Vladana, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells" in Scientific Reports, 8 (2018),
https://doi.org/10.1038/s41598-018-30887-8 . .

TY  - CONF
AU  - Krstić-Ristivojević, Maja
AU  - Apostolović, Danijela
AU  - Tran, T.
AU  - Grundström, Jeanette
AU  - Radoi, Vlad
AU  - Vukojević, Vladana
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2516
PB  - Wiley, Hoboken
C3  - Allergy
T1  - Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells
VL  - 72
SP  - 796
EP  - 796
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2516
ER  - 

@conference{
author = "Krstić-Ristivojević, Maja and Apostolović, Danijela and Tran, T. and Grundström, Jeanette and Radoi, Vlad and Vukojević, Vladana and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2017",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells",
volume = "72",
pages = "796-796",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2516"
}

Krstić-Ristivojević, M., Apostolović, D., Tran, T., Grundström, J., Radoi, V., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2017). Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells. in Allergy
Wiley, Hoboken., 72, 796-796.
https://hdl.handle.net/21.15107/rcub_cherry_2516

Krstić-Ristivojević M, Apostolović D, Tran T, Grundström J, Radoi V, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells. in Allergy. 2017;72:796-796.
https://hdl.handle.net/21.15107/rcub_cherry_2516 .

Krstić-Ristivojević, Maja, Apostolović, Danijela, Tran, T., Grundström, Jeanette, Radoi, Vlad, Vukojević, Vladana, Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells" in Allergy, 72 (2017):796-796,
https://hdl.handle.net/21.15107/rcub_cherry_2516 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Waden, Konrad
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3650
AB  - We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
PB  - Wiley-Blackwell, Hoboken
T2  - Allergy
T1  - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
VL  - 71
IS  - 10
SP  - 1490
EP  - 1495
DO  - 10.1111/all.12955
ER  - 

@article{
author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2016",
abstract = "We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1",
volume = "71",
number = "10",
pages = "1490-1495",
doi = "10.1111/all.12955"
}

Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy
Wiley-Blackwell, Hoboken., 71(10), 1490-1495.
https://doi.org/10.1111/all.12955

Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy. 2016;71(10):1490-1495.
doi:10.1111/all.12955 .

Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1" in Allergy, 71, no. 10 (2016):1490-1495,
https://doi.org/10.1111/all.12955 . .

TY  - DATA
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Waden, Konrad
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3651
PB  - Wiley-Blackwell, Hoboken
T2  - Allergy
T1  - Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3651
ER  - 

@misc{
author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3651"
}

Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955. in Allergy
Wiley-Blackwell, Hoboken..
https://hdl.handle.net/21.15107/rcub_cherry_3651

Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955. in Allergy. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3651 .

Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "Supplementary data for the article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955" in Allergy (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3651 .

TY  - CONF
AU  - Tran, Thi Anh Thu
AU  - Grundström, Jeanette
AU  - Krstić-Ristivojević, Maja
AU  - Vukojević, Vladana
AU  - Apostolović, Danijela
AU  - Hamsten, Carl
AU  - Gafvelin, Guro
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2309
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells
VL  - 71
SP  - 284
EP  - 284
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2309
ER  - 

@conference{
author = "Tran, Thi Anh Thu and Grundström, Jeanette and Krstić-Ristivojević, Maja and Vukojević, Vladana and Apostolović, Danijela and Hamsten, Carl and Gafvelin, Guro and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells",
volume = "71",
pages = "284-284",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2309"
}

Tran, T. A. T., Grundström, J., Krstić-Ristivojević, M., Vukojević, V., Apostolović, D., Hamsten, C., Gafvelin, G.,& van Hage, M.. (2016). In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells. in Allergy
Wiley-Blackwell, Hoboken., 71, 284-284.
https://hdl.handle.net/21.15107/rcub_cherry_2309

Tran TAT, Grundström J, Krstić-Ristivojević M, Vukojević V, Apostolović D, Hamsten C, Gafvelin G, van Hage M. In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells. in Allergy. 2016;71:284-284.
https://hdl.handle.net/21.15107/rcub_cherry_2309 .

Tran, Thi Anh Thu, Grundström, Jeanette, Krstić-Ristivojević, Maja, Vukojević, Vladana, Apostolović, Danijela, Hamsten, Carl, Gafvelin, Guro, van Hage, Marianne, "In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells" in Allergy, 71 (2016):284-284,
https://hdl.handle.net/21.15107/rcub_cherry_2309 .

TY  - CONF
AU  - Krstić-Ristivojević, Maja
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Tran, Thu T. A.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2310
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer
VL  - 71
SP  - 402
EP  - 402
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2310
ER  - 

@conference{
author = "Krstić-Ristivojević, Maja and Apostolović, Danijela and Grundström, Jeanette and Tran, Thu T. A. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer",
volume = "71",
pages = "402-402",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2310"
}

Krstić-Ristivojević, M., Apostolović, D., Grundström, J., Tran, T. T. A., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M.. (2016). alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer. in Allergy
Wiley-Blackwell, Hoboken., 71, 402-402.
https://hdl.handle.net/21.15107/rcub_cherry_2310

Krstić-Ristivojević M, Apostolović D, Grundström J, Tran TTA, Ćirković-Veličković T, Hamsten C, van Hage M. alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer. in Allergy. 2016;71:402-402.
https://hdl.handle.net/21.15107/rcub_cherry_2310 .

Krstić-Ristivojević, Maja, Apostolović, Danijela, Grundström, Jeanette, Tran, Thu T. A., Ćirković-Veličković, Tanja, Hamsten, Carl, van Hage, Marianne, "alpha-Gal epitope on protein surface decreases transcytosis through Caco-2 monolayer" in Allergy, 71 (2016):402-402,
https://hdl.handle.net/21.15107/rcub_cherry_2310 .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Waden, Konrad
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2337
AB  - We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
PB  - Wiley-Blackwell, Hoboken
T2  - Allergy
T1  - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
VL  - 71
IS  - 10
SP  - 1490
EP  - 1495
DO  - 10.1111/all.12955
ER  - 

@article{
author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2016",
abstract = "We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1",
volume = "71",
number = "10",
pages = "1490-1495",
doi = "10.1111/all.12955"
}

Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy
Wiley-Blackwell, Hoboken., 71(10), 1490-1495.
https://doi.org/10.1111/all.12955

Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy. 2016;71(10):1490-1495.
doi:10.1111/all.12955 .

Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1" in Allergy, 71, no. 10 (2016):1490-1495,
https://doi.org/10.1111/all.12955 . .

TY  - CONF
AU  - Waden, Konrad
AU  - Apostolović, Danijela
AU  - Sanchez-Vidaurre, Sara
AU  - Curin, Mirela
AU  - Grundström, Jeanette
AU  - Gafvelin, Guro
AU  - Ćirković-Veličković, Tanja
AU  - Gronlund, Hans
AU  - Thomas, Wayne R.
AU  - Valenta, Rudolf
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2047
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity
VL  - 70
SP  - 517
EP  - 517
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2047
ER  - 

@conference{
author = "Waden, Konrad and Apostolović, Danijela and Sanchez-Vidaurre, Sara and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne",
year = "2015",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity",
volume = "70",
pages = "517-517",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2047"
}

Waden, K., Apostolović, D., Sanchez-Vidaurre, S., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2015). The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity. in Allergy
Wiley-Blackwell, Hoboken., 70, 517-517.
https://hdl.handle.net/21.15107/rcub_cherry_2047

Waden K, Apostolović D, Sanchez-Vidaurre S, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity. in Allergy. 2015;70:517-517.
https://hdl.handle.net/21.15107/rcub_cherry_2047 .

Waden, Konrad, Apostolović, Danijela, Sanchez-Vidaurre, Sara, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The novel cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1: structures, epitopes and allergenicity" in Allergy, 70 (2015):517-517,
https://hdl.handle.net/21.15107/rcub_cherry_2047 .