TY  - JOUR
AU  - Šenk, Milena
AU  - Simić, Milena
AU  - Milojković-Opsenica, Dušanka
AU  - Brankov, Milan
AU  - Tolimir, Miodrag
AU  - Kodranov, Igor D.
AU  - Dragičević, Vesna
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6421
AB  - Climate changes are one of the biggest threats to food security. Sustainable agriculture, focused on eco-friendly practices for highly efficient food production, enables greater resilience and safety. This study experimented on intercropping and bio-fertilizer application as convenient ecological solutions for crop yield stability and quality. The experiment was conducted during 2018 and 2020 with soybean and common millet sown in three sowing patterns: alternating rows, alternating strips 1 (2 rows of soybean + 2 rows of millet), and alternating strips 2 (2 rows of soybean + 4 rows of millet), as well as sole crops (control), with or without a bio-fertilizer Coveron. Grain yield and nutrient grain yield response were calculated through land equivalent ratio (LER) and element-LER (E-LER), while quality was estimated based on the concentration of antioxidants (phytate phosphorus, total phenolic compounds, and yellow pigment) and elements in grains, including potential bio-availability of essential elements. Results revealed LER values to be >1 for all sowing patterns, with the highest one achieved in alternating strips 1 (1.38) together with a greater level of all antioxidants in millet grain. Intercropping significantly enhanced Fe and Mn accumulation in both crops and simultaneously decreased the concentration of potentially toxic elements (Al, Cr) in millet grain. Potential bio-availability of essential elements, expressed through the ratio between phytic acid and Ca, Mg, Fe, and Zn revealed smaller values in intercropped soybean and millet with the bio-fertilizer. The bio-fertilizer also increased the concentration of some micro-elements in millet grain, classifying it as a highly dependent plant to microbial inoculation. Interaction of intercropping and bio-fertilizer was most pronounced for LER, E-LER, and accumulation of Fe and Mn in grains. These results highlighted the benefits of soybean–common millet intercropping, especially in combination with the bio-fertilizer, in light of enhanced land utilization and nutrient absorption, thus increasing the resilience of soybean and millet under dry land conditions and low-input systems toward stability and food security.
T2  - Frontiers in Nutrition
T2  - Frontiers in Nutrition
T1  - Common millet and soybean intercropping with bio-fertilizer as sustainable practice for managing grain yield and quality
VL  - 10
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6421
ER  - 

@article{
author = "Šenk, Milena and Simić, Milena and Milojković-Opsenica, Dušanka and Brankov, Milan and Tolimir, Miodrag and Kodranov, Igor D. and Dragičević, Vesna",
year = "2023",
abstract = "Climate changes are one of the biggest threats to food security. Sustainable agriculture, focused on eco-friendly practices for highly efficient food production, enables greater resilience and safety. This study experimented on intercropping and bio-fertilizer application as convenient ecological solutions for crop yield stability and quality. The experiment was conducted during 2018 and 2020 with soybean and common millet sown in three sowing patterns: alternating rows, alternating strips 1 (2 rows of soybean + 2 rows of millet), and alternating strips 2 (2 rows of soybean + 4 rows of millet), as well as sole crops (control), with or without a bio-fertilizer Coveron. Grain yield and nutrient grain yield response were calculated through land equivalent ratio (LER) and element-LER (E-LER), while quality was estimated based on the concentration of antioxidants (phytate phosphorus, total phenolic compounds, and yellow pigment) and elements in grains, including potential bio-availability of essential elements. Results revealed LER values to be >1 for all sowing patterns, with the highest one achieved in alternating strips 1 (1.38) together with a greater level of all antioxidants in millet grain. Intercropping significantly enhanced Fe and Mn accumulation in both crops and simultaneously decreased the concentration of potentially toxic elements (Al, Cr) in millet grain. Potential bio-availability of essential elements, expressed through the ratio between phytic acid and Ca, Mg, Fe, and Zn revealed smaller values in intercropped soybean and millet with the bio-fertilizer. The bio-fertilizer also increased the concentration of some micro-elements in millet grain, classifying it as a highly dependent plant to microbial inoculation. Interaction of intercropping and bio-fertilizer was most pronounced for LER, E-LER, and accumulation of Fe and Mn in grains. These results highlighted the benefits of soybean–common millet intercropping, especially in combination with the bio-fertilizer, in light of enhanced land utilization and nutrient absorption, thus increasing the resilience of soybean and millet under dry land conditions and low-input systems toward stability and food security.",
journal = "Frontiers in Nutrition, Frontiers in Nutrition",
title = "Common millet and soybean intercropping with bio-fertilizer as sustainable practice for managing grain yield and quality",
volume = "10",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6421"
}

Šenk, M., Simić, M., Milojković-Opsenica, D., Brankov, M., Tolimir, M., Kodranov, I. D.,& Dragičević, V.. (2023). Common millet and soybean intercropping with bio-fertilizer as sustainable practice for managing grain yield and quality. in Frontiers in Nutrition, 10.
https://hdl.handle.net/21.15107/rcub_cherry_6421

Šenk M, Simić M, Milojković-Opsenica D, Brankov M, Tolimir M, Kodranov ID, Dragičević V. Common millet and soybean intercropping with bio-fertilizer as sustainable practice for managing grain yield and quality. in Frontiers in Nutrition. 2023;10.
https://hdl.handle.net/21.15107/rcub_cherry_6421 .

Šenk, Milena, Simić, Milena, Milojković-Opsenica, Dušanka, Brankov, Milan, Tolimir, Miodrag, Kodranov, Igor D., Dragičević, Vesna, "Common millet and soybean intercropping with bio-fertilizer as sustainable practice for managing grain yield and quality" in Frontiers in Nutrition, 10 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6421 .

TY  - JOUR
AU  - Jovanović, Miloš
AU  - Simić, Milena R.
AU  - Petković, Miloš
AU  - Tasić, Gordana
AU  - Maslak, Veselin
AU  - Jovanović, Predrag M.
AU  - Savić, Vladimir
PY  - 2022
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/jhet.4472
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5204
AB  - A photochemically promoted intramolecular cyclization of aryl-, vinyl-, and alkyliodo allenes has been developed. The optimal conditions employed [Ir(ppy)2(dtbbpy)]PF6 (1 mol%) as catalyst affording products with high exo selectivity in moderate to good yields. Chiral substrates showed diastereoselectivity of up to 95/5 favoring trans product.
PB  - Wiley
T2  - Journal of Heterocyclic Chemistry
T1  - Highly exo selective, photochemically promoted cyclization of iodoallene derivatives
VL  - 59
IS  - 8
SP  - 1435
EP  - 1440
DO  - 10.1002/jhet.4472
ER  - 

@article{
author = "Jovanović, Miloš and Simić, Milena R. and Petković, Miloš and Tasić, Gordana and Maslak, Veselin and Jovanović, Predrag M. and Savić, Vladimir",
year = "2022",
abstract = "A photochemically promoted intramolecular cyclization of aryl-, vinyl-, and alkyliodo allenes has been developed. The optimal conditions employed [Ir(ppy)2(dtbbpy)]PF6 (1 mol%) as catalyst affording products with high exo selectivity in moderate to good yields. Chiral substrates showed diastereoselectivity of up to 95/5 favoring trans product.",
publisher = "Wiley",
journal = "Journal of Heterocyclic Chemistry",
title = "Highly exo selective, photochemically promoted cyclization of iodoallene derivatives",
volume = "59",
number = "8",
pages = "1435-1440",
doi = "10.1002/jhet.4472"
}

Jovanović, M., Simić, M. R., Petković, M., Tasić, G., Maslak, V., Jovanović, P. M.,& Savić, V.. (2022). Highly exo selective, photochemically promoted cyclization of iodoallene derivatives. in Journal of Heterocyclic Chemistry
Wiley., 59(8), 1435-1440.
https://doi.org/10.1002/jhet.4472

Jovanović M, Simić MR, Petković M, Tasić G, Maslak V, Jovanović PM, Savić V. Highly exo selective, photochemically promoted cyclization of iodoallene derivatives. in Journal of Heterocyclic Chemistry. 2022;59(8):1435-1440.
doi:10.1002/jhet.4472 .

Jovanović, Miloš, Simić, Milena R., Petković, Miloš, Tasić, Gordana, Maslak, Veselin, Jovanović, Predrag M., Savić, Vladimir, "Highly exo selective, photochemically promoted cyclization of iodoallene derivatives" in Journal of Heterocyclic Chemistry, 59, no. 8 (2022):1435-1440,
https://doi.org/10.1002/jhet.4472 . .

TY  - JOUR
AU  - Assaleh, Mohamed H.
AU  - Božić, Aleksandra R.
AU  - Bjelogrlić, Snežana K.
AU  - Milošević, Milena D.
AU  - Simić, Milena R.
AU  - Marinković, Aleksandar
AU  - Cvijetić, Ilija
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3846
AB  - Thiocarbohydrazones (TCHs) and structurally related molecules are versatile organic compounds which exert antioxidant, anticancer, and other beneficial health effects. The combination of UV/Vis, NMR spectroscopy, and quantum chemical calculations was used to rationalize the experimentally observed increase in the radical scavenging activity upon the addition of water in DMSO solution of TCHs. Mono- and bis(salicylaldehyde) TCHs (compounds 1 and 2) undergo water-induced E-to-Z isomerization which is followed by disruption of intramolecular hydrogen bond, ground state destabilization, and 11 kcal/mol decrease in the bond dissociation enthalpy (BDE). Electron spin delocalization is more pronounced in Z-isomers of 1 and 2. On the other hand, 2-acetylpyridine TCHs (compounds 3 and 4) undergo thione-to-thiol tautomerism which also decreases the BDE and facilitates the hydrogen atom transfer to 2,2-diphenyl-1-picrylhydrazyl radical (DPPH∙). The appearance of thiolic –SH group as another reactive site toward free radicals improves the antioxidant activity of 3 and 4. The spin density of 3- and 4-thiol radicals is delocalized over the entire thiocarbohydrazide moiety compared to more localized spin of thione radicals. Additional stabilization of thiol radicals corroborates with the increased antioxidant activity. This study provides the new insights on the solution structure of TCHs, and also highlights the importance of solution structure determination when studying the structure-antioxidant relationships of isomerizable compounds.
T2  - Structural Chemistry
T1  - Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study
VL  - 30
IS  - 6
SP  - 2447
EP  - 2457
DO  - 10.1007/s11224-019-01371-4
ER  - 

@article{
author = "Assaleh, Mohamed H. and Božić, Aleksandra R. and Bjelogrlić, Snežana K. and Milošević, Milena D. and Simić, Milena R. and Marinković, Aleksandar and Cvijetić, Ilija",
year = "2019",
abstract = "Thiocarbohydrazones (TCHs) and structurally related molecules are versatile organic compounds which exert antioxidant, anticancer, and other beneficial health effects. The combination of UV/Vis, NMR spectroscopy, and quantum chemical calculations was used to rationalize the experimentally observed increase in the radical scavenging activity upon the addition of water in DMSO solution of TCHs. Mono- and bis(salicylaldehyde) TCHs (compounds 1 and 2) undergo water-induced E-to-Z isomerization which is followed by disruption of intramolecular hydrogen bond, ground state destabilization, and 11 kcal/mol decrease in the bond dissociation enthalpy (BDE). Electron spin delocalization is more pronounced in Z-isomers of 1 and 2. On the other hand, 2-acetylpyridine TCHs (compounds 3 and 4) undergo thione-to-thiol tautomerism which also decreases the BDE and facilitates the hydrogen atom transfer to 2,2-diphenyl-1-picrylhydrazyl radical (DPPH∙). The appearance of thiolic –SH group as another reactive site toward free radicals improves the antioxidant activity of 3 and 4. The spin density of 3- and 4-thiol radicals is delocalized over the entire thiocarbohydrazide moiety compared to more localized spin of thione radicals. Additional stabilization of thiol radicals corroborates with the increased antioxidant activity. This study provides the new insights on the solution structure of TCHs, and also highlights the importance of solution structure determination when studying the structure-antioxidant relationships of isomerizable compounds.",
journal = "Structural Chemistry",
title = "Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study",
volume = "30",
number = "6",
pages = "2447-2457",
doi = "10.1007/s11224-019-01371-4"
}

Assaleh, M. H., Božić, A. R., Bjelogrlić, S. K., Milošević, M. D., Simić, M. R., Marinković, A.,& Cvijetić, I.. (2019). Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study. in Structural Chemistry, 30(6), 2447-2457.
https://doi.org/10.1007/s11224-019-01371-4

Assaleh MH, Božić AR, Bjelogrlić SK, Milošević MD, Simić MR, Marinković A, Cvijetić I. Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study. in Structural Chemistry. 2019;30(6):2447-2457.
doi:10.1007/s11224-019-01371-4 .

Assaleh, Mohamed H., Božić, Aleksandra R., Bjelogrlić, Snežana K., Milošević, Milena D., Simić, Milena R., Marinković, Aleksandar, Cvijetić, Ilija, "Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study" in Structural Chemistry, 30, no. 6 (2019):2447-2457,
https://doi.org/10.1007/s11224-019-01371-4 . .

TY  - DATA
AU  - Assaleh, Mohamed H.
AU  - Božić, Aleksandra R.
AU  - Bjelogrlić, Snežana K.
AU  - Milošević, Milena D.
AU  - Simić, Milena R.
AU  - Marinković, Aleksandar
AU  - Cvijetić, Ilija
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3848
T2  - Structural Chemistry
T1  - Supplementary data for the article: Assaleh, M. H.; Božić, A. R.; Bjelogrlić, S.; Milošević, M.; Simić, M.; Marinković, A. D.; Cvijetić, I. N. Water-Induced Isomerism of Salicylaldehyde and 2-Acetylpyridine Mono- and Bis-(Thiocarbohydrazones) Improves the Antioxidant Activity: Spectroscopic and DFT Study. Struct Chem 2019, 30 (6), 2447–2457. https://doi.org/10.1007/s11224-019-01371-4
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3848
ER  - 

@misc{
author = "Assaleh, Mohamed H. and Božić, Aleksandra R. and Bjelogrlić, Snežana K. and Milošević, Milena D. and Simić, Milena R. and Marinković, Aleksandar and Cvijetić, Ilija",
year = "2019",
journal = "Structural Chemistry",
title = "Supplementary data for the article: Assaleh, M. H.; Božić, A. R.; Bjelogrlić, S.; Milošević, M.; Simić, M.; Marinković, A. D.; Cvijetić, I. N. Water-Induced Isomerism of Salicylaldehyde and 2-Acetylpyridine Mono- and Bis-(Thiocarbohydrazones) Improves the Antioxidant Activity: Spectroscopic and DFT Study. Struct Chem 2019, 30 (6), 2447–2457. https://doi.org/10.1007/s11224-019-01371-4",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3848"
}

Assaleh, M. H., Božić, A. R., Bjelogrlić, S. K., Milošević, M. D., Simić, M. R., Marinković, A.,& Cvijetić, I.. (2019). Supplementary data for the article: Assaleh, M. H.; Božić, A. R.; Bjelogrlić, S.; Milošević, M.; Simić, M.; Marinković, A. D.; Cvijetić, I. N. Water-Induced Isomerism of Salicylaldehyde and 2-Acetylpyridine Mono- and Bis-(Thiocarbohydrazones) Improves the Antioxidant Activity: Spectroscopic and DFT Study. Struct Chem 2019, 30 (6), 2447–2457. https://doi.org/10.1007/s11224-019-01371-4. in Structural Chemistry.
https://hdl.handle.net/21.15107/rcub_cherry_3848

Assaleh MH, Božić AR, Bjelogrlić SK, Milošević MD, Simić MR, Marinković A, Cvijetić I. Supplementary data for the article: Assaleh, M. H.; Božić, A. R.; Bjelogrlić, S.; Milošević, M.; Simić, M.; Marinković, A. D.; Cvijetić, I. N. Water-Induced Isomerism of Salicylaldehyde and 2-Acetylpyridine Mono- and Bis-(Thiocarbohydrazones) Improves the Antioxidant Activity: Spectroscopic and DFT Study. Struct Chem 2019, 30 (6), 2447–2457. https://doi.org/10.1007/s11224-019-01371-4. in Structural Chemistry. 2019;.
https://hdl.handle.net/21.15107/rcub_cherry_3848 .

Assaleh, Mohamed H., Božić, Aleksandra R., Bjelogrlić, Snežana K., Milošević, Milena D., Simić, Milena R., Marinković, Aleksandar, Cvijetić, Ilija, "Supplementary data for the article: Assaleh, M. H.; Božić, A. R.; Bjelogrlić, S.; Milošević, M.; Simić, M.; Marinković, A. D.; Cvijetić, I. N. Water-Induced Isomerism of Salicylaldehyde and 2-Acetylpyridine Mono- and Bis-(Thiocarbohydrazones) Improves the Antioxidant Activity: Spectroscopic and DFT Study. Struct Chem 2019, 30 (6), 2447–2457. https://doi.org/10.1007/s11224-019-01371-4" in Structural Chemistry (2019),
https://hdl.handle.net/21.15107/rcub_cherry_3848 .

TY  - DATA
AU  - Mesarović, Jelena
AU  - Srdić, Jelena
AU  - Mladenović-Drinić, Snežana
AU  - Dragičević, Vesna
AU  - Simić, Milena R.
AU  - Brankov, Milan
AU  - Milojković-Opsenica, Dušanka
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2883
PB  - Elsevier
T2  - Journal of Cereal Science
T1  - Supplementary data for the article: Mesarović, J.; Srdić, J.; Mladenović-Drinić, S.; Dragičević, V.; Simić, M.; Brankov, M.; Milojković-Opsenica, D. Evaluation of the Nutritional Profile of Sweet Maize after Herbicide and Foliar Fertilizer Application. J. Cereal Sci. 2019, 87, 132–137. https://doi.org/10.1016/j.jcs.2019.03.017
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2883
ER  - 

@misc{
author = "Mesarović, Jelena and Srdić, Jelena and Mladenović-Drinić, Snežana and Dragičević, Vesna and Simić, Milena R. and Brankov, Milan and Milojković-Opsenica, Dušanka",
year = "2019",
publisher = "Elsevier",
journal = "Journal of Cereal Science",
title = "Supplementary data for the article: Mesarović, J.; Srdić, J.; Mladenović-Drinić, S.; Dragičević, V.; Simić, M.; Brankov, M.; Milojković-Opsenica, D. Evaluation of the Nutritional Profile of Sweet Maize after Herbicide and Foliar Fertilizer Application. J. Cereal Sci. 2019, 87, 132–137. https://doi.org/10.1016/j.jcs.2019.03.017",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2883"
}

Mesarović, J., Srdić, J., Mladenović-Drinić, S., Dragičević, V., Simić, M. R., Brankov, M.,& Milojković-Opsenica, D.. (2019). Supplementary data for the article: Mesarović, J.; Srdić, J.; Mladenović-Drinić, S.; Dragičević, V.; Simić, M.; Brankov, M.; Milojković-Opsenica, D. Evaluation of the Nutritional Profile of Sweet Maize after Herbicide and Foliar Fertilizer Application. J. Cereal Sci. 2019, 87, 132–137. https://doi.org/10.1016/j.jcs.2019.03.017. in Journal of Cereal Science
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_2883

Mesarović J, Srdić J, Mladenović-Drinić S, Dragičević V, Simić MR, Brankov M, Milojković-Opsenica D. Supplementary data for the article: Mesarović, J.; Srdić, J.; Mladenović-Drinić, S.; Dragičević, V.; Simić, M.; Brankov, M.; Milojković-Opsenica, D. Evaluation of the Nutritional Profile of Sweet Maize after Herbicide and Foliar Fertilizer Application. J. Cereal Sci. 2019, 87, 132–137. https://doi.org/10.1016/j.jcs.2019.03.017. in Journal of Cereal Science. 2019;.
https://hdl.handle.net/21.15107/rcub_cherry_2883 .

Mesarović, Jelena, Srdić, Jelena, Mladenović-Drinić, Snežana, Dragičević, Vesna, Simić, Milena R., Brankov, Milan, Milojković-Opsenica, Dušanka, "Supplementary data for the article: Mesarović, J.; Srdić, J.; Mladenović-Drinić, S.; Dragičević, V.; Simić, M.; Brankov, M.; Milojković-Opsenica, D. Evaluation of the Nutritional Profile of Sweet Maize after Herbicide and Foliar Fertilizer Application. J. Cereal Sci. 2019, 87, 132–137. https://doi.org/10.1016/j.jcs.2019.03.017" in Journal of Cereal Science (2019),
https://hdl.handle.net/21.15107/rcub_cherry_2883 .

TY  - JOUR
AU  - Milenković, Milena
AU  - Simić, Milena R.
AU  - Brankov, Milan
AU  - Milojković-Opsenica, Dušanka
AU  - Kresović, Branka
AU  - Dragičević, Vesna
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3928
AB  - Sustainable agriculture considers production of high quality food and feed with minimal impact on environment. Intercropping is one of the most efficient ways to produce valuable biomass for animal feed rich in nutrients. Intercrop combinations: alternating rows of soybean and proso millet (S-M), alternating strips with 2 rows of soybean and 2 rows of millet (SS-MM-SS) and alternating strips with 2 rows of soybean and 4 rows of millet (SS-MMMM-SS); single crop of soybean and single crop of proso millet were tested. The effect of bio-fertilizer Coveron was also followed. Aboveground biomass was harvested and land equivalent ratio (LER), as well as leaf area index (LAI) was determined. All intercropping combinations increased LAI of soybean when compared to monocrop, to 43% and 84% in SS-MM-SS combination with and without Coveron, respectively. Coveron slightly increased LAI. The highest values of biomass yield were obtained in S-M intercrop for soybean (39% and 42% higher in relation to monocrop, in combination with and without Coveron, respectively) and in monocrop for proso millet. Nevertheless, the highest LER value was obtained for SS-MM-SS combination without Coveron (1.12). In intercrops treated with Coveron slightly lower LER values were obtained for S-M and SS-MMMM-SS combination (0.97 and 0.98, respectively). Irrespective to sowing way, results indicate that 1:1 ratio of soybean and proso millet in intercrop (S-M and SS-MM-SS combinations) is the most promising way to achieve high biomass yield.
PB  - Novi Sad : Nacionalno društvo za procesnu tehniku i energetiku u poljoprivredi
T2  - Journal on Processing and Energy in Agriculture
T1  - Intercropping of soybean and proso millet for biomass production
VL  - 23
IS  - 1
SP  - 38
EP  - 40
EP  - M51
DO  - 10.5937/jpea1901038M
ER  - 

@article{
author = "Milenković, Milena and Simić, Milena R. and Brankov, Milan and Milojković-Opsenica, Dušanka and Kresović, Branka and Dragičević, Vesna",
year = "2019",
abstract = "Sustainable agriculture considers production of high quality food and feed with minimal impact on environment. Intercropping is one of the most efficient ways to produce valuable biomass for animal feed rich in nutrients. Intercrop combinations: alternating rows of soybean and proso millet (S-M), alternating strips with 2 rows of soybean and 2 rows of millet (SS-MM-SS) and alternating strips with 2 rows of soybean and 4 rows of millet (SS-MMMM-SS); single crop of soybean and single crop of proso millet were tested. The effect of bio-fertilizer Coveron was also followed. Aboveground biomass was harvested and land equivalent ratio (LER), as well as leaf area index (LAI) was determined. All intercropping combinations increased LAI of soybean when compared to monocrop, to 43% and 84% in SS-MM-SS combination with and without Coveron, respectively. Coveron slightly increased LAI. The highest values of biomass yield were obtained in S-M intercrop for soybean (39% and 42% higher in relation to monocrop, in combination with and without Coveron, respectively) and in monocrop for proso millet. Nevertheless, the highest LER value was obtained for SS-MM-SS combination without Coveron (1.12). In intercrops treated with Coveron slightly lower LER values were obtained for S-M and SS-MMMM-SS combination (0.97 and 0.98, respectively). Irrespective to sowing way, results indicate that 1:1 ratio of soybean and proso millet in intercrop (S-M and SS-MM-SS combinations) is the most promising way to achieve high biomass yield.",
publisher = "Novi Sad : Nacionalno društvo za procesnu tehniku i energetiku u poljoprivredi",
journal = "Journal on Processing and Energy in Agriculture",
title = "Intercropping of soybean and proso millet for biomass production",
volume = "23",
number = "1",
pages = "38-40-M51",
doi = "10.5937/jpea1901038M"
}

Milenković, M., Simić, M. R., Brankov, M., Milojković-Opsenica, D., Kresović, B.,& Dragičević, V.. (2019). Intercropping of soybean and proso millet for biomass production. in Journal on Processing and Energy in Agriculture
Novi Sad : Nacionalno društvo za procesnu tehniku i energetiku u poljoprivredi., 23(1), 38-40.
https://doi.org/10.5937/jpea1901038M

Milenković M, Simić MR, Brankov M, Milojković-Opsenica D, Kresović B, Dragičević V. Intercropping of soybean and proso millet for biomass production. in Journal on Processing and Energy in Agriculture. 2019;23(1):38-40.
doi:10.5937/jpea1901038M .

Milenković, Milena, Simić, Milena R., Brankov, Milan, Milojković-Opsenica, Dušanka, Kresović, Branka, Dragičević, Vesna, "Intercropping of soybean and proso millet for biomass production" in Journal on Processing and Energy in Agriculture, 23, no. 1 (2019):38-40,
https://doi.org/10.5937/jpea1901038M . .

TY  - JOUR
AU  - Mesarović, Jelena
AU  - Srdić, Jelena
AU  - Mladenović-Drinić, Snežana
AU  - Dragičević, Vesna
AU  - Simić, Milena R.
AU  - Brankov, Milan
AU  - Milojković-Opsenica, Dušanka
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2978
AB  - Intensive weed management is required to meet the growing demands of sweet maize production. Herbicide application is inevitable in sweet maize production, while foliar fertilizer is commonly used in cropping in order to improve crop yield and quality. The effect of nicosulfuron and mesotrione, with and without foliar fertilizer, on the content of phytochemicals (i.e. carotenoids, tocopherols and free phenolic acids) in the kernels of three sweet maize hybrids was evaluated. Herbicides applied alone mainly improved the nutritive profile of the sweet maize kernel. The application of herbicides in combination with foliar fertilizer showed a high variability in the concentration of carotenoids, tocopherols and free phenolic acids. The significant change in the content of phytochemicals was induced by the applied treatments, but it is also genotype-dependent, which was also confirmed by the Principal Component Analysis.
PB  - Elsevier
T2  - Journal of Cereal Science
T1  - Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application
VL  - 87
SP  - 132
EP  - 137
DO  - 10.1016/j.jcs.2019.03.017
ER  - 

@article{
author = "Mesarović, Jelena and Srdić, Jelena and Mladenović-Drinić, Snežana and Dragičević, Vesna and Simić, Milena R. and Brankov, Milan and Milojković-Opsenica, Dušanka",
year = "2019",
abstract = "Intensive weed management is required to meet the growing demands of sweet maize production. Herbicide application is inevitable in sweet maize production, while foliar fertilizer is commonly used in cropping in order to improve crop yield and quality. The effect of nicosulfuron and mesotrione, with and without foliar fertilizer, on the content of phytochemicals (i.e. carotenoids, tocopherols and free phenolic acids) in the kernels of three sweet maize hybrids was evaluated. Herbicides applied alone mainly improved the nutritive profile of the sweet maize kernel. The application of herbicides in combination with foliar fertilizer showed a high variability in the concentration of carotenoids, tocopherols and free phenolic acids. The significant change in the content of phytochemicals was induced by the applied treatments, but it is also genotype-dependent, which was also confirmed by the Principal Component Analysis.",
publisher = "Elsevier",
journal = "Journal of Cereal Science",
title = "Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application",
volume = "87",
pages = "132-137",
doi = "10.1016/j.jcs.2019.03.017"
}

Mesarović, J., Srdić, J., Mladenović-Drinić, S., Dragičević, V., Simić, M. R., Brankov, M.,& Milojković-Opsenica, D.. (2019). Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application. in Journal of Cereal Science
Elsevier., 87, 132-137.
https://doi.org/10.1016/j.jcs.2019.03.017

Mesarović J, Srdić J, Mladenović-Drinić S, Dragičević V, Simić MR, Brankov M, Milojković-Opsenica D. Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application. in Journal of Cereal Science. 2019;87:132-137.
doi:10.1016/j.jcs.2019.03.017 .

Mesarović, Jelena, Srdić, Jelena, Mladenović-Drinić, Snežana, Dragičević, Vesna, Simić, Milena R., Brankov, Milan, Milojković-Opsenica, Dušanka, "Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application" in Journal of Cereal Science, 87 (2019):132-137,
https://doi.org/10.1016/j.jcs.2019.03.017 . .

TY  - JOUR
AU  - Mesarović, Jelena
AU  - Srdić, Jelena
AU  - Mladenović-Drinić, Snežana
AU  - Dragičević, Vesna
AU  - Simić, Milena R.
AU  - Brankov, Milan
AU  - Milojković-Opsenica, Dušanka
PY  - 2019
AB  - Intensive weed management is required to meet the growing demands of sweet maize production. Herbicide application is inevitable in sweet maize production, while foliar fertilizer is commonly used in cropping in order to improve crop yield and quality. The effect of nicosulfuron and mesotrione, with and without foliar fertilizer, on the content of phytochemicals (i.e. carotenoids, tocopherols and free phenolic acids) in the kernels of three sweet maize hybrids was evaluated. Herbicides applied alone mainly improved the nutritive profile of the sweet maize kernel. The application of herbicides in combination with foliar fertilizer showed a high variability in the concentration of carotenoids, tocopherols and free phenolic acids. The significant change in the content of phytochemicals was induced by the applied treatments, but it is also genotype-dependent, which was also confirmed by the Principal Component Analysis.
PB  - Elsevier
T2  - Journal of Cereal Science
T1  - Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application
VL  - 87
SP  - 132
EP  - 137
DO  - 10.1016/j.jcs.2019.03.017
ER  - 

@article{
author = "Mesarović, Jelena and Srdić, Jelena and Mladenović-Drinić, Snežana and Dragičević, Vesna and Simić, Milena R. and Brankov, Milan and Milojković-Opsenica, Dušanka",
year = "2019",
abstract = "Intensive weed management is required to meet the growing demands of sweet maize production. Herbicide application is inevitable in sweet maize production, while foliar fertilizer is commonly used in cropping in order to improve crop yield and quality. The effect of nicosulfuron and mesotrione, with and without foliar fertilizer, on the content of phytochemicals (i.e. carotenoids, tocopherols and free phenolic acids) in the kernels of three sweet maize hybrids was evaluated. Herbicides applied alone mainly improved the nutritive profile of the sweet maize kernel. The application of herbicides in combination with foliar fertilizer showed a high variability in the concentration of carotenoids, tocopherols and free phenolic acids. The significant change in the content of phytochemicals was induced by the applied treatments, but it is also genotype-dependent, which was also confirmed by the Principal Component Analysis.",
publisher = "Elsevier",
journal = "Journal of Cereal Science",
title = "Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application",
volume = "87",
pages = "132-137",
doi = "10.1016/j.jcs.2019.03.017"
}

Mesarović, J., Srdić, J., Mladenović-Drinić, S., Dragičević, V., Simić, M. R., Brankov, M.,& Milojković-Opsenica, D.. (2019). Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application. in Journal of Cereal Science
Elsevier., 87, 132-137.
https://doi.org/10.1016/j.jcs.2019.03.017

Mesarović J, Srdić J, Mladenović-Drinić S, Dragičević V, Simić MR, Brankov M, Milojković-Opsenica D. Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application. in Journal of Cereal Science. 2019;87:132-137.
doi:10.1016/j.jcs.2019.03.017 .

Mesarović, Jelena, Srdić, Jelena, Mladenović-Drinić, Snežana, Dragičević, Vesna, Simić, Milena R., Brankov, Milan, Milojković-Opsenica, Dušanka, "Evaluation of the nutritional profile of sweet maize after herbicide and foliar fertilizer application" in Journal of Cereal Science, 87 (2019):132-137,
https://doi.org/10.1016/j.jcs.2019.03.017 . .

TY  - JOUR
AU  - Mesarović, Jelena
AU  - Srdić, Jelena
AU  - Mladenović-Drinić, Snežana
AU  - Dragičević, Vesna
AU  - Simić, Milena R.
AU  - Brankov, Milan
AU  - Milojković-Opsenica, Dušanka
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2823
AB  - Hemijske mere u suzbijanju korova su neophodan korak u tehnologiji gajenja kukuruza šećerca. Kod useva, primena herbicida mote dovesti do abiotickog stresa koji negativno utiče na neenzimske antioksidanse, pogotovo kod osetljivijih genotipova, kao štoćje kukuruz šećerac. Antioksidativni profil je ispitivan merenjem koncentracije rastvorljivih fenolnih jedinjenja, karotenoida, fitinske kiseline i glutationa u svetem zrnu tri hibrida kukuruza šecerca nakon primene herbicida, folijarnog Cubriva kao i njihovih kombinacija, u poljskom ogledu, tokom dve godine. Sadrtaj antioksidanasa je varirao u zavisnosti od hibrida, klimatskih uslova tokom vegetacionog perioda, kao i od primenjenih tretmana. Sulfonilurea herbicid je značajno povećao antiokidativni status zrna u poreCenju sa triketonskim herbicidom. Kombinacija herbicid plus folijarno Cubrivo je znacajno uticala na variranja antioksidativnog profila zrna. Pored toga, zabeletene su značajne korelacije (pozitivna i negativna) izmeCu prinosa i sadrtaja ispitivanih antioksidanasa tri hibrida kukuruza šećerca.
AB  - The chemical method of weed control is an indispensable step in cropping practices of sweet maize. Application of the herbicides can induce the abiotic stress which affects the non-enzymatic antioxidants in the crops, especially on the sensitive one, like sweet maize is. Antioxidant profile, through the measurement of the soluble phenolic, carotenoids, phytic acid and glutathione concentration, in the grain of the three sweet maize hybrids after application of herbicides, foliar fertilizer, as well as their combinations, in field experiment, conducted over a two-year period, was determined. The content of tested antioxidant parameters was dependent on hybrids, growing season, as well as of the applied treatment. Sulfonylurea herbicides significantly increased the antioxidant status of sweet maize fresh grain, compared to the herbicide from triketone group, without affecting the fresh grain yield. Combination of herbicide plus foliar fertilizer expressed a various impact on antioxidant profile of the maize grain. Furthermore, significant correlations (positive and negative) between fresh grain yield and analyzed antioxidants in grain of three sweet maize hybrids were noticed.
T2  - Genetika
T1  - Antioxidant status of the different sweet maize hybrids under herbicide and foliar fertilizer application
VL  - 50
IS  - 3
SP  - 1023
EP  - 1033
DO  - 10.2298/GENSR1803023M
ER  - 

@article{
author = "Mesarović, Jelena and Srdić, Jelena and Mladenović-Drinić, Snežana and Dragičević, Vesna and Simić, Milena R. and Brankov, Milan and Milojković-Opsenica, Dušanka",
year = "2018",
abstract = "Hemijske mere u suzbijanju korova su neophodan korak u tehnologiji gajenja kukuruza šećerca. Kod useva, primena herbicida mote dovesti do abiotickog stresa koji negativno utiče na neenzimske antioksidanse, pogotovo kod osetljivijih genotipova, kao štoćje kukuruz šećerac. Antioksidativni profil je ispitivan merenjem koncentracije rastvorljivih fenolnih jedinjenja, karotenoida, fitinske kiseline i glutationa u svetem zrnu tri hibrida kukuruza šecerca nakon primene herbicida, folijarnog Cubriva kao i njihovih kombinacija, u poljskom ogledu, tokom dve godine. Sadrtaj antioksidanasa je varirao u zavisnosti od hibrida, klimatskih uslova tokom vegetacionog perioda, kao i od primenjenih tretmana. Sulfonilurea herbicid je značajno povećao antiokidativni status zrna u poreCenju sa triketonskim herbicidom. Kombinacija herbicid plus folijarno Cubrivo je znacajno uticala na variranja antioksidativnog profila zrna. Pored toga, zabeletene su značajne korelacije (pozitivna i negativna) izmeCu prinosa i sadrtaja ispitivanih antioksidanasa tri hibrida kukuruza šećerca., The chemical method of weed control is an indispensable step in cropping practices of sweet maize. Application of the herbicides can induce the abiotic stress which affects the non-enzymatic antioxidants in the crops, especially on the sensitive one, like sweet maize is. Antioxidant profile, through the measurement of the soluble phenolic, carotenoids, phytic acid and glutathione concentration, in the grain of the three sweet maize hybrids after application of herbicides, foliar fertilizer, as well as their combinations, in field experiment, conducted over a two-year period, was determined. The content of tested antioxidant parameters was dependent on hybrids, growing season, as well as of the applied treatment. Sulfonylurea herbicides significantly increased the antioxidant status of sweet maize fresh grain, compared to the herbicide from triketone group, without affecting the fresh grain yield. Combination of herbicide plus foliar fertilizer expressed a various impact on antioxidant profile of the maize grain. Furthermore, significant correlations (positive and negative) between fresh grain yield and analyzed antioxidants in grain of three sweet maize hybrids were noticed.",
journal = "Genetika",
title = "Antioxidant status of the different sweet maize hybrids under herbicide and foliar fertilizer application",
volume = "50",
number = "3",
pages = "1023-1033",
doi = "10.2298/GENSR1803023M"
}

Mesarović, J., Srdić, J., Mladenović-Drinić, S., Dragičević, V., Simić, M. R., Brankov, M.,& Milojković-Opsenica, D.. (2018). Antioxidant status of the different sweet maize hybrids under herbicide and foliar fertilizer application. in Genetika, 50(3), 1023-1033.
https://doi.org/10.2298/GENSR1803023M

Mesarović J, Srdić J, Mladenović-Drinić S, Dragičević V, Simić MR, Brankov M, Milojković-Opsenica D. Antioxidant status of the different sweet maize hybrids under herbicide and foliar fertilizer application. in Genetika. 2018;50(3):1023-1033.
doi:10.2298/GENSR1803023M .

Mesarović, Jelena, Srdić, Jelena, Mladenović-Drinić, Snežana, Dragičević, Vesna, Simić, Milena R., Brankov, Milan, Milojković-Opsenica, Dušanka, "Antioxidant status of the different sweet maize hybrids under herbicide and foliar fertilizer application" in Genetika, 50, no. 3 (2018):1023-1033,
https://doi.org/10.2298/GENSR1803023M . .

TY  - JOUR
AU  - Simić, Milena R.
AU  - Paunović, Nikola
AU  - Borić, Ivan
AU  - Ranđelović, Jelena
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Pekmezović, Marina
AU  - Savić, Vladimir
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2008
AB  - A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. (C) 2015 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies
VL  - 26
IS  - 1
SP  - 235
EP  - 239
DO  - 10.1016/j.bmcl.2015.08.086
ER  - 

@article{
author = "Simić, Milena R. and Paunović, Nikola and Borić, Ivan and Ranđelović, Jelena and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Pekmezović, Marina and Savić, Vladimir",
year = "2016",
abstract = "A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. (C) 2015 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies",
volume = "26",
number = "1",
pages = "235-239",
doi = "10.1016/j.bmcl.2015.08.086"
}

Simić, M. R., Paunović, N., Borić, I., Ranđelović, J., Vojnović, S., Nikodinović-Runić, J., Pekmezović, M.,& Savić, V.. (2016). Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 26(1), 235-239.
https://doi.org/10.1016/j.bmcl.2015.08.086

Simić MR, Paunović N, Borić I, Ranđelović J, Vojnović S, Nikodinović-Runić J, Pekmezović M, Savić V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic and Medicinal Chemistry Letters. 2016;26(1):235-239.
doi:10.1016/j.bmcl.2015.08.086 .

Simić, Milena R., Paunović, Nikola, Borić, Ivan, Ranđelović, Jelena, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Pekmezović, Marina, Savić, Vladimir, "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies" in Bioorganic and Medicinal Chemistry Letters, 26, no. 1 (2016):235-239,
https://doi.org/10.1016/j.bmcl.2015.08.086 . .

TY  - JOUR
AU  - Mandić, Boris
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana S.
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1692
AB  - Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge
VL  - 29
IS  - 9
SP  - 887
EP  - 890
DO  - 10.1080/14786419.2014.991929
ER  - 

@article{
author = "Mandić, Boris and Vlajić, Marina D. and Trifunović, Snežana S. and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Novaković, Miroslav M. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2015",
abstract = "Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge",
volume = "29",
number = "9",
pages = "887-890",
doi = "10.1080/14786419.2014.991929"
}

Mandić, B., Vlajić, M. D., Trifunović, S. S., Simić, M. R., Vujisić, L. V., Vučković, I. M., Novaković, M. M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(9), 887-890.
https://doi.org/10.1080/14786419.2014.991929

Mandić B, Vlajić MD, Trifunović SS, Simić MR, Vujisić LV, Vučković IM, Novaković MM, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research. 2015;29(9):887-890.
doi:10.1080/14786419.2014.991929 .

Mandić, Boris, Vlajić, Marina D., Trifunović, Snežana S., Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan M., Novaković, Miroslav M., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge" in Natural Product Research, 29, no. 9 (2015):887-890,
https://doi.org/10.1080/14786419.2014.991929 . .

TY  - DATA
AU  - Mandić, Boris
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana S.
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3388
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3388
ER  - 

@misc{
author = "Mandić, Boris and Vlajić, Marina D. and Trifunović, Snežana S. and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Novaković, Miroslav M. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2015",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3388"
}

Mandić, B., Vlajić, M. D., Trifunović, S. S., Simić, M. R., Vujisić, L. V., Vučković, I. M., Novaković, M. M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2015). Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
https://hdl.handle.net/21.15107/rcub_cherry_3388

Mandić B, Vlajić MD, Trifunović SS, Simić MR, Vujisić LV, Vučković IM, Novaković MM, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929. in Natural Product Research. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3388 .

Mandić, Boris, Vlajić, Marina D., Trifunović, Snežana S., Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan M., Novaković, Miroslav M., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929" in Natural Product Research (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3388 .

TY  - JOUR
AU  - Simić, Milena R.
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Savić, Vladimir
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1660
AB  - Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Archiv der Pharmazie
T1  - Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes
VL  - 348
IS  - 2
SP  - 100
EP  - 112
DO  - 10.1002/ardp.201400350
ER  - 

@article{
author = "Simić, Milena R. and Stanković, Miroslava and Mandić, Boris and Tešević, Vele and Savić, Vladimir",
year = "2015",
abstract = "Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Archiv der Pharmazie",
title = "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes",
volume = "348",
number = "2",
pages = "100-112",
doi = "10.1002/ardp.201400350"
}

Simić, M. R., Stanković, M., Mandić, B., Tešević, V.,& Savić, V.. (2015). Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie
Wiley-V C H Verlag Gmbh, Weinheim., 348(2), 100-112.
https://doi.org/10.1002/ardp.201400350

Simić MR, Stanković M, Mandić B, Tešević V, Savić V. Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie. 2015;348(2):100-112.
doi:10.1002/ardp.201400350 .

Simić, Milena R., Stanković, Miroslava, Mandić, Boris, Tešević, Vele, Savić, Vladimir, "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes" in Archiv der Pharmazie, 348, no. 2 (2015):100-112,
https://doi.org/10.1002/ardp.201400350 . .

TY  - DATA
AU  - Tasić, Gordana
AU  - Simić, Milena R.
AU  - Popovic, Stanimir
AU  - Husinec, Suren
AU  - Maslak, Veselin
AU  - Savić, Vladimir
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3501
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron Letters
T1  - Supplementary data for article: Tasić, G.; Simić, M. R.; Popovic, S.; Husinec, S.; Maslak, V.; Savić, V. Indirect N-Vinylation of Indoles via Isomerisation of N-Allyl Derivatives: Synthesis of (+/-)-Debromoarborescidine B. Tetrahedron Letters 2013, 54 (34), 4536–4539. https://doi.org/10.1016/j.tetlet.2013.06.069
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3501
ER  - 

@misc{
author = "Tasić, Gordana and Simić, Milena R. and Popovic, Stanimir and Husinec, Suren and Maslak, Veselin and Savić, Vladimir",
year = "2013",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron Letters",
title = "Supplementary data for article: Tasić, G.; Simić, M. R.; Popovic, S.; Husinec, S.; Maslak, V.; Savić, V. Indirect N-Vinylation of Indoles via Isomerisation of N-Allyl Derivatives: Synthesis of (+/-)-Debromoarborescidine B. Tetrahedron Letters 2013, 54 (34), 4536–4539. https://doi.org/10.1016/j.tetlet.2013.06.069",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3501"
}

Tasić, G., Simić, M. R., Popovic, S., Husinec, S., Maslak, V.,& Savić, V.. (2013). Supplementary data for article: Tasić, G.; Simić, M. R.; Popovic, S.; Husinec, S.; Maslak, V.; Savić, V. Indirect N-Vinylation of Indoles via Isomerisation of N-Allyl Derivatives: Synthesis of (+/-)-Debromoarborescidine B. Tetrahedron Letters 2013, 54 (34), 4536–4539. https://doi.org/10.1016/j.tetlet.2013.06.069. in Tetrahedron Letters
Pergamon-Elsevier Science Ltd, Oxford..
https://hdl.handle.net/21.15107/rcub_cherry_3501

Tasić G, Simić MR, Popovic S, Husinec S, Maslak V, Savić V. Supplementary data for article: Tasić, G.; Simić, M. R.; Popovic, S.; Husinec, S.; Maslak, V.; Savić, V. Indirect N-Vinylation of Indoles via Isomerisation of N-Allyl Derivatives: Synthesis of (+/-)-Debromoarborescidine B. Tetrahedron Letters 2013, 54 (34), 4536–4539. https://doi.org/10.1016/j.tetlet.2013.06.069. in Tetrahedron Letters. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3501 .

Tasić, Gordana, Simić, Milena R., Popovic, Stanimir, Husinec, Suren, Maslak, Veselin, Savić, Vladimir, "Supplementary data for article: Tasić, G.; Simić, M. R.; Popovic, S.; Husinec, S.; Maslak, V.; Savić, V. Indirect N-Vinylation of Indoles via Isomerisation of N-Allyl Derivatives: Synthesis of (+/-)-Debromoarborescidine B. Tetrahedron Letters 2013, 54 (34), 4536–4539. https://doi.org/10.1016/j.tetlet.2013.06.069" in Tetrahedron Letters (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3501 .

TY  - JOUR
AU  - Mandić, Boris
AU  - Simić, Milena R.
AU  - Vučković, Ivan M.
AU  - Vujisić, Ljubodrag V.
AU  - Novaković, Miroslav M.
AU  - Trifunović, Snežana S.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1494
AB  - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
PB  - Mdpi Ag, Basel
T2  - Molecules
T1  - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
VL  - 18
IS  - 9
SP  - 10694
EP  - 10706
DO  - 10.3390/molecules180910694
ER  - 

@article{
author = "Mandić, Boris and Simić, Milena R. and Vučković, Ivan M. and Vujisić, Ljubodrag V. and Novaković, Miroslav M. and Trifunović, Snežana S. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2013",
abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.",
publisher = "Mdpi Ag, Basel",
journal = "Molecules",
title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization",
volume = "18",
number = "9",
pages = "10694-10706",
doi = "10.3390/molecules180910694"
}

Mandić, B., Simić, M. R., Vučković, I. M., Vujisić, L. V., Novaković, M. M., Trifunović, S. S., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules
Mdpi Ag, Basel., 18(9), 10694-10706.
https://doi.org/10.3390/molecules180910694

Mandić B, Simić MR, Vučković IM, Vujisić LV, Novaković MM, Trifunović SS, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706.
doi:10.3390/molecules180910694 .

Mandić, Boris, Simić, Milena R., Vučković, Ivan M., Vujisić, Ljubodrag V., Novaković, Miroslav M., Trifunović, Snežana S., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706,
https://doi.org/10.3390/molecules180910694 . .

TY  - JOUR
AU  - Tasić, Gordana
AU  - Simić, Milena R.
AU  - Popovic, Stanimir
AU  - Husinec, Suren
AU  - Maslak, Veselin
AU  - Savić, Vladimir
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1382
AB  - Double bond migration in N-allylindoles has been investigated as a method to access N-vinyl derivatives of this heterocycle. The optimal reaction conditions employed t-BuOK or NaH in DMSO as the solvent at room temperature to afford the products in yields ranging from 51 to 99%. Although in some cases a high degree of stereoselectivity was observed, preferential formation of either the Z- or E-isomer was not predictable. The developed methodology was employed in the synthesis of (+/-)-debromoarborescidine B.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron Letters
T1  - Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B
VL  - 54
IS  - 34
SP  - 4536
EP  - 4539
DO  - 10.1016/j.tetlet.2013.06.069
ER  - 

@article{
author = "Tasić, Gordana and Simić, Milena R. and Popovic, Stanimir and Husinec, Suren and Maslak, Veselin and Savić, Vladimir",
year = "2013",
abstract = "Double bond migration in N-allylindoles has been investigated as a method to access N-vinyl derivatives of this heterocycle. The optimal reaction conditions employed t-BuOK or NaH in DMSO as the solvent at room temperature to afford the products in yields ranging from 51 to 99%. Although in some cases a high degree of stereoselectivity was observed, preferential formation of either the Z- or E-isomer was not predictable. The developed methodology was employed in the synthesis of (+/-)-debromoarborescidine B.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron Letters",
title = "Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B",
volume = "54",
number = "34",
pages = "4536-4539",
doi = "10.1016/j.tetlet.2013.06.069"
}

Tasić, G., Simić, M. R., Popovic, S., Husinec, S., Maslak, V.,& Savić, V.. (2013). Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B. in Tetrahedron Letters
Pergamon-Elsevier Science Ltd, Oxford., 54(34), 4536-4539.
https://doi.org/10.1016/j.tetlet.2013.06.069

Tasić G, Simić MR, Popovic S, Husinec S, Maslak V, Savić V. Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B. in Tetrahedron Letters. 2013;54(34):4536-4539.
doi:10.1016/j.tetlet.2013.06.069 .

Tasić, Gordana, Simić, Milena R., Popovic, Stanimir, Husinec, Suren, Maslak, Veselin, Savić, Vladimir, "Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B" in Tetrahedron Letters, 54, no. 34 (2013):4536-4539,
https://doi.org/10.1016/j.tetlet.2013.06.069 . .

TY  - THES
AU  - Simić, Milena R.
PY  - 2012
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=247
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:5519/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=43575311
UR  - http://nardus.mpn.gov.rs/123456789/3463
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2607
AB  - Cilj ove doktorske teze bio je razvoj nove sinteze protoberberinskih derivata,policikličnih jedinjenja koja sadrže izohinolinski skelet. Protoberberini predstavljajuširoko rasprostranjenu, važnu grupu izohinolinskih alkaloida. Zahvaljujući njihovimizraženim farmakološkim osobinama interes za ovu grupu jedinjenja je u stalnomporastu.Novi sintetski put koji omogućuje pristup različitim klasama protoberberinabaziran je na dobijanju zajedničkog intermedijera, 1,3-diena izohinolinske strukture.Diels-Alderovom reakcijom sa različitim dienofilima i oksidacijom nastalihcikloadukata omogućena je instalacija prstena C u različitim oksidacionim stanjima kaoi dodatnih supstituenata potrebnih za funkcionalizaciju prstena D protoberberina. Naovaj način dobijene su dve vrste skeleta prirodnih proizvoda, tetrahidroprotoberberinskii oksoprotoberberinski.Ova sintetska metodologija pokazala se primenljivom i na dihidro-β-karbolin ipiridin. Alkaloidi koji su derivati β-karbolina su jedinjenja koja pokazuju veoma širokspektar bioloških aktivnosti, tako da postoji interes za razvoj metodologije zafunkcionalizaciju ovog heterocikličnog jedinjenja.Polazeći od dihidro-β-karbolina, preko odgovarajućeg intermedijernog 1,3-diena, dobijene su dve klase jedinjenja, ketojobirinska i dihidrogambirtaninska. Piridinse takoñe pokazao pogodnim za ovu vrstu anelacija, pri čemu su dobijenebenzohinolizinske strukture, slične nekim biološki aktivnim jedinjenjima.Ispitivano je in vitro citotoksično dejstvo nekih sintetisanih izohinolinskih i β-karbolinskih derivata na maligne ćelijske linije (FemX, HeLa, K562). Najznačajnijucitotoksičnu aktivnost od ispitivanih jedinjenja pokazao je izohinolinski cikloadukt 2.17prema K562 ćelijama (IC50=24,7 μM)Pored ovoga, ispitivana je funkcionalizacija 1,3-dienskog sistema paladijumomkatalizovanim reakcijama, što je omogućilo dobijanje alilnih acetata sa izohinolinskom iβ-karbolinskom strukturom...
AB  - The aim of this thesis was the development of a synthetic route forprotoberberine derivatives, polycyclic compounds containing the isoquinoline skeleton.The protoberberines are widespread, important group of isoquinoline alkaloids.Due to the potent pharmacological properties they have attracted an attention frommedicinal chemist and drug researchers. Our proposed synthetic route enabling accessto different classes of protoberberines is based on a common intermediate, anisoquinolinic 1,3-diene. The incorporation of ring C in various oxidative states, as wellas the incorporation of additional substituents necessary for the functionalisation of ringD of protoberberines was achieved through Diels-Alder reactions with differentdienophiles and the subsequent oxidation of the resulting cycloadducts. Two types ofnatural products' skeletons, tetrahydroprotoberberines and oxoprotoberberines wereefficiently synthesised using this approach. This synthetic methodology proved to beapplicable in the preparation of dihydro-β-carbolines and pyridines. Alkaloids derivedof β-carboline are important compounds with a broad spectrum of biological activities.Starting with dihydro-β-carboline, through the corresponding intermediary 1,3-diene, ketoyobirines and dihydrogambirtanines were obtained. Pyridine had also shownamenable to these types of annulations, giving benzoquinolizine structures.In vitro cytotoxic activity of some synthetised isoquinolines and β-carbolineswas investigated (FemX, HeLa, K562). Cycloadduct 2.17 shows the greatest cytotoxicactivity of the compounds tested, with IC50 value of 24,7 μM towards K562 cells.In addition to this, the possibility of functionalization of 1,3-diene system in Pdcatalysedreaction was also explored, enabling access to different allylic acetates withisoquinoline and β-carboline structure...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Anelacije heterocikličnih jedinjenja i njihova primena u sintezi prirodnih proizvoda
T1  - Annulations of heterocyclic compounds and their application in synthesis of natural compounds
UR  - https://hdl.handle.net/21.15107/rcub_nardus_3463
ER  - 

@phdthesis{
author = "Simić, Milena R.",
year = "2012",
abstract = "Cilj ove doktorske teze bio je razvoj nove sinteze protoberberinskih derivata,policikličnih jedinjenja koja sadrže izohinolinski skelet. Protoberberini predstavljajuširoko rasprostranjenu, važnu grupu izohinolinskih alkaloida. Zahvaljujući njihovimizraženim farmakološkim osobinama interes za ovu grupu jedinjenja je u stalnomporastu.Novi sintetski put koji omogućuje pristup različitim klasama protoberberinabaziran je na dobijanju zajedničkog intermedijera, 1,3-diena izohinolinske strukture.Diels-Alderovom reakcijom sa različitim dienofilima i oksidacijom nastalihcikloadukata omogućena je instalacija prstena C u različitim oksidacionim stanjima kaoi dodatnih supstituenata potrebnih za funkcionalizaciju prstena D protoberberina. Naovaj način dobijene su dve vrste skeleta prirodnih proizvoda, tetrahidroprotoberberinskii oksoprotoberberinski.Ova sintetska metodologija pokazala se primenljivom i na dihidro-β-karbolin ipiridin. Alkaloidi koji su derivati β-karbolina su jedinjenja koja pokazuju veoma širokspektar bioloških aktivnosti, tako da postoji interes za razvoj metodologije zafunkcionalizaciju ovog heterocikličnog jedinjenja.Polazeći od dihidro-β-karbolina, preko odgovarajućeg intermedijernog 1,3-diena, dobijene su dve klase jedinjenja, ketojobirinska i dihidrogambirtaninska. Piridinse takoñe pokazao pogodnim za ovu vrstu anelacija, pri čemu su dobijenebenzohinolizinske strukture, slične nekim biološki aktivnim jedinjenjima.Ispitivano je in vitro citotoksično dejstvo nekih sintetisanih izohinolinskih i β-karbolinskih derivata na maligne ćelijske linije (FemX, HeLa, K562). Najznačajnijucitotoksičnu aktivnost od ispitivanih jedinjenja pokazao je izohinolinski cikloadukt 2.17prema K562 ćelijama (IC50=24,7 μM)Pored ovoga, ispitivana je funkcionalizacija 1,3-dienskog sistema paladijumomkatalizovanim reakcijama, što je omogućilo dobijanje alilnih acetata sa izohinolinskom iβ-karbolinskom strukturom..., The aim of this thesis was the development of a synthetic route forprotoberberine derivatives, polycyclic compounds containing the isoquinoline skeleton.The protoberberines are widespread, important group of isoquinoline alkaloids.Due to the potent pharmacological properties they have attracted an attention frommedicinal chemist and drug researchers. Our proposed synthetic route enabling accessto different classes of protoberberines is based on a common intermediate, anisoquinolinic 1,3-diene. The incorporation of ring C in various oxidative states, as wellas the incorporation of additional substituents necessary for the functionalisation of ringD of protoberberines was achieved through Diels-Alder reactions with differentdienophiles and the subsequent oxidation of the resulting cycloadducts. Two types ofnatural products' skeletons, tetrahydroprotoberberines and oxoprotoberberines wereefficiently synthesised using this approach. This synthetic methodology proved to beapplicable in the preparation of dihydro-β-carbolines and pyridines. Alkaloids derivedof β-carboline are important compounds with a broad spectrum of biological activities.Starting with dihydro-β-carboline, through the corresponding intermediary 1,3-diene, ketoyobirines and dihydrogambirtanines were obtained. Pyridine had also shownamenable to these types of annulations, giving benzoquinolizine structures.In vitro cytotoxic activity of some synthetised isoquinolines and β-carbolineswas investigated (FemX, HeLa, K562). Cycloadduct 2.17 shows the greatest cytotoxicactivity of the compounds tested, with IC50 value of 24,7 μM towards K562 cells.In addition to this, the possibility of functionalization of 1,3-diene system in Pdcatalysedreaction was also explored, enabling access to different allylic acetates withisoquinoline and β-carboline structure...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Anelacije heterocikličnih jedinjenja i njihova primena u sintezi prirodnih proizvoda, Annulations of heterocyclic compounds and their application in synthesis of natural compounds",
url = "https://hdl.handle.net/21.15107/rcub_nardus_3463"
}

Simić, M. R.. (2012). Anelacije heterocikličnih jedinjenja i njihova primena u sintezi prirodnih proizvoda. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_3463

Simić MR. Anelacije heterocikličnih jedinjenja i njihova primena u sintezi prirodnih proizvoda. in Универзитет у Београду. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_3463 .

Simić, Milena R., "Anelacije heterocikličnih jedinjenja i njihova primena u sintezi prirodnih proizvoda" in Универзитет у Београду (2012),
https://hdl.handle.net/21.15107/rcub_nardus_3463 .

TY  - DATA
AU  - Husinec, Suren
AU  - Savić, Vladimir
AU  - Simić, Milena R.
AU  - Tešević, Vele
AU  - Vidović, Dragoslav
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3572
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron Letters
T1  - Supplementary data for article: Husinec, S.; Savić, V.; Simić, M. R.; Tešević, V.; Vidovic, D. Annulations of Isoquinoline and Beta-Carboline Ring Systems: Synthesis of 8-Oxoprotoberberine Derivatives. Tetrahedron Letters 2011, 52 (21), 2733–2736. https://doi.org/10.1016/j.tetlet.2011.03.085
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3572
ER  - 

@misc{
author = "Husinec, Suren and Savić, Vladimir and Simić, Milena R. and Tešević, Vele and Vidović, Dragoslav",
year = "2011",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron Letters",
title = "Supplementary data for article: Husinec, S.; Savić, V.; Simić, M. R.; Tešević, V.; Vidovic, D. Annulations of Isoquinoline and Beta-Carboline Ring Systems: Synthesis of 8-Oxoprotoberberine Derivatives. Tetrahedron Letters 2011, 52 (21), 2733–2736. https://doi.org/10.1016/j.tetlet.2011.03.085",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3572"
}

Husinec, S., Savić, V., Simić, M. R., Tešević, V.,& Vidović, D.. (2011). Supplementary data for article: Husinec, S.; Savić, V.; Simić, M. R.; Tešević, V.; Vidovic, D. Annulations of Isoquinoline and Beta-Carboline Ring Systems: Synthesis of 8-Oxoprotoberberine Derivatives. Tetrahedron Letters 2011, 52 (21), 2733–2736. https://doi.org/10.1016/j.tetlet.2011.03.085. in Tetrahedron Letters
Pergamon-Elsevier Science Ltd, Oxford..
https://hdl.handle.net/21.15107/rcub_cherry_3572

Husinec S, Savić V, Simić MR, Tešević V, Vidović D. Supplementary data for article: Husinec, S.; Savić, V.; Simić, M. R.; Tešević, V.; Vidovic, D. Annulations of Isoquinoline and Beta-Carboline Ring Systems: Synthesis of 8-Oxoprotoberberine Derivatives. Tetrahedron Letters 2011, 52 (21), 2733–2736. https://doi.org/10.1016/j.tetlet.2011.03.085. in Tetrahedron Letters. 2011;.
https://hdl.handle.net/21.15107/rcub_cherry_3572 .

Husinec, Suren, Savić, Vladimir, Simić, Milena R., Tešević, Vele, Vidović, Dragoslav, "Supplementary data for article: Husinec, S.; Savić, V.; Simić, M. R.; Tešević, V.; Vidovic, D. Annulations of Isoquinoline and Beta-Carboline Ring Systems: Synthesis of 8-Oxoprotoberberine Derivatives. Tetrahedron Letters 2011, 52 (21), 2733–2736. https://doi.org/10.1016/j.tetlet.2011.03.085" in Tetrahedron Letters (2011),
https://hdl.handle.net/21.15107/rcub_cherry_3572 .

TY  - JOUR
AU  - Husinec, Suren
AU  - Savić, Vladimir
AU  - Simić, Milena R.
AU  - Tešević, Vele
AU  - Vidović, Dragoslav
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1342
AB  - Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron Letters
T1  - Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives
VL  - 52
IS  - 21
SP  - 2733
EP  - 2736
DO  - 10.1016/j.tetlet.2011.03.085
ER  - 

@article{
author = "Husinec, Suren and Savić, Vladimir and Simić, Milena R. and Tešević, Vele and Vidović, Dragoslav",
year = "2011",
abstract = "Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron Letters",
title = "Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives",
volume = "52",
number = "21",
pages = "2733-2736",
doi = "10.1016/j.tetlet.2011.03.085"
}

Husinec, S., Savić, V., Simić, M. R., Tešević, V.,& Vidović, D.. (2011). Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives. in Tetrahedron Letters
Pergamon-Elsevier Science Ltd, Oxford., 52(21), 2733-2736.
https://doi.org/10.1016/j.tetlet.2011.03.085

Husinec S, Savić V, Simić MR, Tešević V, Vidović D. Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives. in Tetrahedron Letters. 2011;52(21):2733-2736.
doi:10.1016/j.tetlet.2011.03.085 .

Husinec, Suren, Savić, Vladimir, Simić, Milena R., Tešević, Vele, Vidović, Dragoslav, "Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives" in Tetrahedron Letters, 52, no. 21 (2011):2733-2736,
https://doi.org/10.1016/j.tetlet.2011.03.085 . .

TY  - JOUR
AU  - Mandić, Boris
AU  - Gođevac, Dejan
AU  - Beškoski, Vladimir
AU  - Simić, Milena R.
AU  - Trifunović, Snežana S.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/602
AB  - The genus Senecio (family Asteraceae) is one of the largest in the world. It comprises about 1100 species which are the rich source of pyrrolizidine alkaloids. Plants containing pyrrolizidine alkaloids are among the most important sources of human and animal exposure to plant toxins and carcinogens. The pyrrolizidine alkaloids of seven Senecio species (S. erucifolius, S. othonnae, S. wagneri, S. subalpinus, S. carpathicus, S. paludosus and S. rupestris) were studied. Fourteen alkaloids were isolated and their structures determined from spectroscopic data ((1)H- and (13)C-NMR, IR and MS). Five of them were identified in S. erucifolius, four in S. othonnae, two in S. wagneri, four in S. subalpinus, two in S. carpathicus, three in S. paludosus and three in S. rupestris. Seven pyrrolizidine alkaloids were found for the first time in particular species. The results have chemotaxonomic importance. The cytotoxic activity and antimicrobial activity of some alkaloids were also studied.
AB  - Jedan od najbrojnijih rodova na svetu je rod Senecio (familija Asteraceae). Obuhvata oko 1100 vrsta koje predstavljaju bogat izvor pirolizidinskih alkaloida. Najznačajnija izloženost ljudi i životinja biljnim toksinima i karcinogenima potiče od biljaka koje sadrže pirolizidinske alkaloide. U ovom radu izolovani su pirolizidinski alkaloidi iz sedam vrsta roda Senecio (S. erucifolius, S. othonnae, S. wagneri, S. subalpinus, S. carpathicus, S. paludosus i S. rupestris), a njihove strukture određene na bazi spektroskopskih podataka (1H- i 13C-NMR, IR i MS). Izolovano je ukupno 14 alkaloida, pet iz S. erucifolius, četiri iz S. othonnae, dva iz S. wagneri, četiri iz S. subalpinus, dva iz S. carpathicus, tri iz S. paludosus i tri iz S. rupestris. Sedam pirolizidinskih alkaloida je po prvi put izolovano iz nekih pojedinačnih vrsta. Dobijeni rezultati imaju hemotaksonomski značaj. Ispitana je citotoksičnost i antimikrobna aktivnost izolovanih alkaloida.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro
T1  - Pirolizidinski alkaloidi iz sedam samoniklih biljnih vrsta roda Senecio koje rastu u Srbiji i Crnoj Gori
VL  - 74
IS  - 1
SP  - 27
EP  - 34
DO  - 10.2298/JSC0901027M
ER  - 

@article{
author = "Mandić, Boris and Gođevac, Dejan and Beškoski, Vladimir and Simić, Milena R. and Trifunović, Snežana S. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2009",
abstract = "The genus Senecio (family Asteraceae) is one of the largest in the world. It comprises about 1100 species which are the rich source of pyrrolizidine alkaloids. Plants containing pyrrolizidine alkaloids are among the most important sources of human and animal exposure to plant toxins and carcinogens. The pyrrolizidine alkaloids of seven Senecio species (S. erucifolius, S. othonnae, S. wagneri, S. subalpinus, S. carpathicus, S. paludosus and S. rupestris) were studied. Fourteen alkaloids were isolated and their structures determined from spectroscopic data ((1)H- and (13)C-NMR, IR and MS). Five of them were identified in S. erucifolius, four in S. othonnae, two in S. wagneri, four in S. subalpinus, two in S. carpathicus, three in S. paludosus and three in S. rupestris. Seven pyrrolizidine alkaloids were found for the first time in particular species. The results have chemotaxonomic importance. The cytotoxic activity and antimicrobial activity of some alkaloids were also studied., Jedan od najbrojnijih rodova na svetu je rod Senecio (familija Asteraceae). Obuhvata oko 1100 vrsta koje predstavljaju bogat izvor pirolizidinskih alkaloida. Najznačajnija izloženost ljudi i životinja biljnim toksinima i karcinogenima potiče od biljaka koje sadrže pirolizidinske alkaloide. U ovom radu izolovani su pirolizidinski alkaloidi iz sedam vrsta roda Senecio (S. erucifolius, S. othonnae, S. wagneri, S. subalpinus, S. carpathicus, S. paludosus i S. rupestris), a njihove strukture određene na bazi spektroskopskih podataka (1H- i 13C-NMR, IR i MS). Izolovano je ukupno 14 alkaloida, pet iz S. erucifolius, četiri iz S. othonnae, dva iz S. wagneri, četiri iz S. subalpinus, dva iz S. carpathicus, tri iz S. paludosus i tri iz S. rupestris. Sedam pirolizidinskih alkaloida je po prvi put izolovano iz nekih pojedinačnih vrsta. Dobijeni rezultati imaju hemotaksonomski značaj. Ispitana je citotoksičnost i antimikrobna aktivnost izolovanih alkaloida.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro, Pirolizidinski alkaloidi iz sedam samoniklih biljnih vrsta roda Senecio koje rastu u Srbiji i Crnoj Gori",
volume = "74",
number = "1",
pages = "27-34",
doi = "10.2298/JSC0901027M"
}

Mandić, B., Gođevac, D., Beškoski, V., Simić, M. R., Trifunović, S. S., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2009). Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 74(1), 27-34.
https://doi.org/10.2298/JSC0901027M

Mandić B, Gođevac D, Beškoski V, Simić MR, Trifunović SS, Tešević V, Vajs V, Milosavljević SM. Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro. in Journal of the Serbian Chemical Society. 2009;74(1):27-34.
doi:10.2298/JSC0901027M .

Mandić, Boris, Gođevac, Dejan, Beškoski, Vladimir, Simić, Milena R., Trifunović, Snežana S., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro" in Journal of the Serbian Chemical Society, 74, no. 1 (2009):27-34,
https://doi.org/10.2298/JSC0901027M . .

TY  - JOUR
AU  - Rakic, S
AU  - Povrenovic, D
AU  - Tešević, Vele
AU  - Simić, Milena R.
AU  - Maletić, Radojka
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/755
AB  - In this paper, are presented the results of physical and chemical investigations of differently treated samples of oak acorn. The aim of this investigation is to estimate the influence of thermal treatment on physical and nutritive characteristics of investigated samples. Oak acorn, Quercus robur, (belonging to Fagaceae family) was investigated in native and thermally treated forms. By subsequent extraction of dry toasted oak acorn (Quercus semen tostum) the aqueous extract was obtained which is then dried in a spout-fluid bed. The content of total polyphenols, then polyphenols unadsorbed on hide powder and tannins was determined by spectrophotometric methods with phosphor-wolfram acid according to Ph. Yug. V. Galic acid was determined by HPLC. The total antioxidant activity (TAA) of the aqueous extract compared to the control samples of pigs fat and synthetic antioxidant butylated hydroxyanisole BHA was estimated by Schall-Oven test at 60 +/- 1 degrees C in dark, and oxidative changes were determined by measuring the Peroxide value (PV). For determination of macro- and microelements the method of AAS was used. By detecting the changes of PV it is established that aqueous extract was influencing the stability of pigs fat, that is, showing the antioxidant activity. The activity was increasing with increasing concentration in tested samples. The obtained results regarding the total polyphenols content, the content of galic acid, nitrogen compounds, macro and microelements show that acorn, after treatment, was retaining and in some cases improving its functional properties. (c) 2005 Elsevier Ltd. All rights reserved.
PB  - Elsevier Sci Ltd, Oxford
T2  - Journal of Food Engineering
T1  - Oak acorn, polyphenols and antioxidant activity in functional food
VL  - 74
IS  - 3
SP  - 416
EP  - 423
DO  - 10.1016/j.jfoodeng.2005.03.057
ER  - 

@article{
author = "Rakic, S and Povrenovic, D and Tešević, Vele and Simić, Milena R. and Maletić, Radojka",
year = "2006",
abstract = "In this paper, are presented the results of physical and chemical investigations of differently treated samples of oak acorn. The aim of this investigation is to estimate the influence of thermal treatment on physical and nutritive characteristics of investigated samples. Oak acorn, Quercus robur, (belonging to Fagaceae family) was investigated in native and thermally treated forms. By subsequent extraction of dry toasted oak acorn (Quercus semen tostum) the aqueous extract was obtained which is then dried in a spout-fluid bed. The content of total polyphenols, then polyphenols unadsorbed on hide powder and tannins was determined by spectrophotometric methods with phosphor-wolfram acid according to Ph. Yug. V. Galic acid was determined by HPLC. The total antioxidant activity (TAA) of the aqueous extract compared to the control samples of pigs fat and synthetic antioxidant butylated hydroxyanisole BHA was estimated by Schall-Oven test at 60 +/- 1 degrees C in dark, and oxidative changes were determined by measuring the Peroxide value (PV). For determination of macro- and microelements the method of AAS was used. By detecting the changes of PV it is established that aqueous extract was influencing the stability of pigs fat, that is, showing the antioxidant activity. The activity was increasing with increasing concentration in tested samples. The obtained results regarding the total polyphenols content, the content of galic acid, nitrogen compounds, macro and microelements show that acorn, after treatment, was retaining and in some cases improving its functional properties. (c) 2005 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Journal of Food Engineering",
title = "Oak acorn, polyphenols and antioxidant activity in functional food",
volume = "74",
number = "3",
pages = "416-423",
doi = "10.1016/j.jfoodeng.2005.03.057"
}

Rakic, S., Povrenovic, D., Tešević, V., Simić, M. R.,& Maletić, R.. (2006). Oak acorn, polyphenols and antioxidant activity in functional food. in Journal of Food Engineering
Elsevier Sci Ltd, Oxford., 74(3), 416-423.
https://doi.org/10.1016/j.jfoodeng.2005.03.057

Rakic S, Povrenovic D, Tešević V, Simić MR, Maletić R. Oak acorn, polyphenols and antioxidant activity in functional food. in Journal of Food Engineering. 2006;74(3):416-423.
doi:10.1016/j.jfoodeng.2005.03.057 .

Rakic, S, Povrenovic, D, Tešević, Vele, Simić, Milena R., Maletić, Radojka, "Oak acorn, polyphenols and antioxidant activity in functional food" in Journal of Food Engineering, 74, no. 3 (2006):416-423,
https://doi.org/10.1016/j.jfoodeng.2005.03.057 . .