TY  - JOUR
AU  - Rašković, Aleksandar
AU  - Martić, Nikola
AU  - Tomas, Ana
AU  - Andrejić-Višnjić, Bojana
AU  - Bosanac, Milana
AU  - Atanasković, Marko
AU  - Nemet, Marko
AU  - Popović, Radmila
AU  - Krstić, Marko
AU  - Vukmirović, Saša
AU  - Stilinović, Nebojša
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6396
AB  - Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with carob extract and simvastatin for four weeks. After sacrifice, blood samples were collected for biochemical analysis, and liver tissue was taken for histological and immunohistochemical assessment. Weight gain was significantly higher in groups fed with cholesterol-fortified granules; total cholesterol was found to be significantly lower in the hypercholesterolemic groups treated with simvastatin and simvastatin/carob combined regimens compared with hypercholesterolemic animals treated with saline (p < 0.05). The same was true for low-density lipoprotein cholesterol and the LDL/HDL ratio (p < 0.05). Adiponectin was remarkably higher in animals treated with simvastatin compared to all other groups (p < 0.05). Leptin was significantly lower in groups treated with carob and simvastatin compared to the hypercholesterolemic group treated with saline (p < 0.05). Carob/simvastatin co-administration reduced hepatocyte damage and improved liver morphology. A study confirmed the anti-dyslipidemic, anti-obesity, and hepatoprotective potential of carob pulp alone or in combination with simvastatin in the treatment of high-fat diet-fed rats.
PB  - MDPI
T2  - Pharmaceutics
T1  - Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model
VL  - 15
IS  - 11
SP  - 2611
DO  - 10.3390/pharmaceutics15112611
ER  - 

@article{
author = "Rašković, Aleksandar and Martić, Nikola and Tomas, Ana and Andrejić-Višnjić, Bojana and Bosanac, Milana and Atanasković, Marko and Nemet, Marko and Popović, Radmila and Krstić, Marko and Vukmirović, Saša and Stilinović, Nebojša",
year = "2023",
abstract = "Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with carob extract and simvastatin for four weeks. After sacrifice, blood samples were collected for biochemical analysis, and liver tissue was taken for histological and immunohistochemical assessment. Weight gain was significantly higher in groups fed with cholesterol-fortified granules; total cholesterol was found to be significantly lower in the hypercholesterolemic groups treated with simvastatin and simvastatin/carob combined regimens compared with hypercholesterolemic animals treated with saline (p < 0.05). The same was true for low-density lipoprotein cholesterol and the LDL/HDL ratio (p < 0.05). Adiponectin was remarkably higher in animals treated with simvastatin compared to all other groups (p < 0.05). Leptin was significantly lower in groups treated with carob and simvastatin compared to the hypercholesterolemic group treated with saline (p < 0.05). Carob/simvastatin co-administration reduced hepatocyte damage and improved liver morphology. A study confirmed the anti-dyslipidemic, anti-obesity, and hepatoprotective potential of carob pulp alone or in combination with simvastatin in the treatment of high-fat diet-fed rats.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model",
volume = "15",
number = "11",
pages = "2611",
doi = "10.3390/pharmaceutics15112611"
}

Rašković, A., Martić, N., Tomas, A., Andrejić-Višnjić, B., Bosanac, M., Atanasković, M., Nemet, M., Popović, R., Krstić, M., Vukmirović, S.,& Stilinović, N.. (2023). Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model. in Pharmaceutics
MDPI., 15(11), 2611.
https://doi.org/10.3390/pharmaceutics15112611

Rašković A, Martić N, Tomas A, Andrejić-Višnjić B, Bosanac M, Atanasković M, Nemet M, Popović R, Krstić M, Vukmirović S, Stilinović N. Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model. in Pharmaceutics. 2023;15(11):2611.
doi:10.3390/pharmaceutics15112611 .

Rašković, Aleksandar, Martić, Nikola, Tomas, Ana, Andrejić-Višnjić, Bojana, Bosanac, Milana, Atanasković, Marko, Nemet, Marko, Popović, Radmila, Krstić, Marko, Vukmirović, Saša, Stilinović, Nebojša, "Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model" in Pharmaceutics, 15, no. 11 (2023):2611,
https://doi.org/10.3390/pharmaceutics15112611 . .