TY  - JOUR
AU  - Anđelković, Uroš
AU  - Tufegdžić, Srđan
AU  - Popović, Milica M.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2557
AB  - The exclusive properties of monolithic supports enable fast mass transfer, high porosity, low back pressure, easy preparation process and miniaturisation, and the availability of different chemistries make them particularly suitable materials for high-throughput (HTP) protein and peptide separation. In this review recent advances in monolith-based chromatographic supports for HTP screening of protein and peptide samples are presented and their application in HTP sample preparation (separation, enrichment, depletion, proteolytic digestion) for HTP proteomics is discussed. Development and applications of different monolithic capillary columns in HTP MS-based bottom-up and top-down proteomics are overviewed. By discussing the chromatographic conditions and the mass spectrometric data acquisition conditions an attempt is made to present currently demonstrated capacities of monolithic capillary columns for HTP identification and quantification of proteins and peptides from complex biological samples by MS-based proteomics. Some recent advances in basic monolith technology of importance for proteomics are also discussed.
PB  - Wiley, Hoboken
T2  - Electrophoresis
T1  - Use of monolithic supports for high-throughput protein and peptide separation in proteomics
VL  - 38
IS  - 22-23
SP  - 2851
EP  - 2869
DO  - 10.1002/elps.201700221
ER  - 

@article{
author = "Anđelković, Uroš and Tufegdžić, Srđan and Popović, Milica M.",
year = "2017",
abstract = "The exclusive properties of monolithic supports enable fast mass transfer, high porosity, low back pressure, easy preparation process and miniaturisation, and the availability of different chemistries make them particularly suitable materials for high-throughput (HTP) protein and peptide separation. In this review recent advances in monolith-based chromatographic supports for HTP screening of protein and peptide samples are presented and their application in HTP sample preparation (separation, enrichment, depletion, proteolytic digestion) for HTP proteomics is discussed. Development and applications of different monolithic capillary columns in HTP MS-based bottom-up and top-down proteomics are overviewed. By discussing the chromatographic conditions and the mass spectrometric data acquisition conditions an attempt is made to present currently demonstrated capacities of monolithic capillary columns for HTP identification and quantification of proteins and peptides from complex biological samples by MS-based proteomics. Some recent advances in basic monolith technology of importance for proteomics are also discussed.",
publisher = "Wiley, Hoboken",
journal = "Electrophoresis",
title = "Use of monolithic supports for high-throughput protein and peptide separation in proteomics",
volume = "38",
number = "22-23",
pages = "2851-2869",
doi = "10.1002/elps.201700221"
}

Anđelković, U., Tufegdžić, S.,& Popović, M. M.. (2017). Use of monolithic supports for high-throughput protein and peptide separation in proteomics. in Electrophoresis
Wiley, Hoboken., 38(22-23), 2851-2869.
https://doi.org/10.1002/elps.201700221

Anđelković U, Tufegdžić S, Popović MM. Use of monolithic supports for high-throughput protein and peptide separation in proteomics. in Electrophoresis. 2017;38(22-23):2851-2869.
doi:10.1002/elps.201700221 .

Anđelković, Uroš, Tufegdžić, Srđan, Popović, Milica M., "Use of monolithic supports for high-throughput protein and peptide separation in proteomics" in Electrophoresis, 38, no. 22-23 (2017):2851-2869,
https://doi.org/10.1002/elps.201700221 . .

TY  - JOUR
AU  - Anđelković, Uroš
AU  - Tufegdžić, Srđan
AU  - Popović, Milica M.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2976
AB  - The exclusive properties of monolithic supports enable fast mass transfer, high porosity, low back pressure, easy preparation process and miniaturisation, and the availability of different chemistries make them particularly suitable materials for high-throughput (HTP) protein and peptide separation. In this review recent advances in monolith-based chromatographic supports for HTP screening of protein and peptide samples are presented and their application in HTP sample preparation (separation, enrichment, depletion, proteolytic digestion) for HTP proteomics is discussed. Development and applications of different monolithic capillary columns in HTP MS-based bottom-up and top-down proteomics are overviewed. By discussing the chromatographic conditions and the mass spectrometric data acquisition conditions an attempt is made to present currently demonstrated capacities of monolithic capillary columns for HTP identification and quantification of proteins and peptides from complex biological samples by MS-based proteomics. Some recent advances in basic monolith technology of importance for proteomics are also discussed.
PB  - Wiley, Hoboken
T2  - Electrophoresis
T1  - Use of monolithic supports for high-throughput protein and peptide separation in proteomics
VL  - 38
IS  - 22-23
SP  - 2851
EP  - 2869
DO  - 10.1002/elps.201700221
ER  - 

@article{
author = "Anđelković, Uroš and Tufegdžić, Srđan and Popović, Milica M.",
year = "2017",
abstract = "The exclusive properties of monolithic supports enable fast mass transfer, high porosity, low back pressure, easy preparation process and miniaturisation, and the availability of different chemistries make them particularly suitable materials for high-throughput (HTP) protein and peptide separation. In this review recent advances in monolith-based chromatographic supports for HTP screening of protein and peptide samples are presented and their application in HTP sample preparation (separation, enrichment, depletion, proteolytic digestion) for HTP proteomics is discussed. Development and applications of different monolithic capillary columns in HTP MS-based bottom-up and top-down proteomics are overviewed. By discussing the chromatographic conditions and the mass spectrometric data acquisition conditions an attempt is made to present currently demonstrated capacities of monolithic capillary columns for HTP identification and quantification of proteins and peptides from complex biological samples by MS-based proteomics. Some recent advances in basic monolith technology of importance for proteomics are also discussed.",
publisher = "Wiley, Hoboken",
journal = "Electrophoresis",
title = "Use of monolithic supports for high-throughput protein and peptide separation in proteomics",
volume = "38",
number = "22-23",
pages = "2851-2869",
doi = "10.1002/elps.201700221"
}

Anđelković, U., Tufegdžić, S.,& Popović, M. M.. (2017). Use of monolithic supports for high-throughput protein and peptide separation in proteomics. in Electrophoresis
Wiley, Hoboken., 38(22-23), 2851-2869.
https://doi.org/10.1002/elps.201700221

Anđelković U, Tufegdžić S, Popović MM. Use of monolithic supports for high-throughput protein and peptide separation in proteomics. in Electrophoresis. 2017;38(22-23):2851-2869.
doi:10.1002/elps.201700221 .

Anđelković, Uroš, Tufegdžić, Srđan, Popović, Milica M., "Use of monolithic supports for high-throughput protein and peptide separation in proteomics" in Electrophoresis, 38, no. 22-23 (2017):2851-2869,
https://doi.org/10.1002/elps.201700221 . .

TY  - DATA
AU  - Vilipić, Jovana
AU  - Novaković, Irena T.
AU  - Zlatović, Mario
AU  - Vujčić, Miroslava
AU  - Tufegdžić, Srđan
AU  - Sladić, Dušan
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3545
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary material for the article: Vilipić, J. P.; Novaković, I. T.; Zlatović, M. V.; Vujčić, M. T.; Tufegdžić, S. J.; Sladić, D. M. Interactions of Cytotoxic Amino Acid Derivatives of Tert-Butylquinone with DNA and Lysozyme. Journal of the Serbian Chemical Society 2016, 81 (12), 1345–1358. https://doi.org/10.2298/JSC160725101V
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3545
ER  - 

@misc{
author = "Vilipić, Jovana and Novaković, Irena T. and Zlatović, Mario and Vujčić, Miroslava and Tufegdžić, Srđan and Sladić, Dušan",
year = "2016",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary material for the article: Vilipić, J. P.; Novaković, I. T.; Zlatović, M. V.; Vujčić, M. T.; Tufegdžić, S. J.; Sladić, D. M. Interactions of Cytotoxic Amino Acid Derivatives of Tert-Butylquinone with DNA and Lysozyme. Journal of the Serbian Chemical Society 2016, 81 (12), 1345–1358. https://doi.org/10.2298/JSC160725101V",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3545"
}

Vilipić, J., Novaković, I. T., Zlatović, M., Vujčić, M., Tufegdžić, S.,& Sladić, D.. (2016). Supplementary material for the article: Vilipić, J. P.; Novaković, I. T.; Zlatović, M. V.; Vujčić, M. T.; Tufegdžić, S. J.; Sladić, D. M. Interactions of Cytotoxic Amino Acid Derivatives of Tert-Butylquinone with DNA and Lysozyme. Journal of the Serbian Chemical Society 2016, 81 (12), 1345–1358. https://doi.org/10.2298/JSC160725101V. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade..
https://hdl.handle.net/21.15107/rcub_cherry_3545

Vilipić J, Novaković IT, Zlatović M, Vujčić M, Tufegdžić S, Sladić D. Supplementary material for the article: Vilipić, J. P.; Novaković, I. T.; Zlatović, M. V.; Vujčić, M. T.; Tufegdžić, S. J.; Sladić, D. M. Interactions of Cytotoxic Amino Acid Derivatives of Tert-Butylquinone with DNA and Lysozyme. Journal of the Serbian Chemical Society 2016, 81 (12), 1345–1358. https://doi.org/10.2298/JSC160725101V. in Journal of the Serbian Chemical Society. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3545 .

Vilipić, Jovana, Novaković, Irena T., Zlatović, Mario, Vujčić, Miroslava, Tufegdžić, Srđan, Sladić, Dušan, "Supplementary material for the article: Vilipić, J. P.; Novaković, I. T.; Zlatović, M. V.; Vujčić, M. T.; Tufegdžić, S. J.; Sladić, D. M. Interactions of Cytotoxic Amino Acid Derivatives of Tert-Butylquinone with DNA and Lysozyme. Journal of the Serbian Chemical Society 2016, 81 (12), 1345–1358. https://doi.org/10.2298/JSC160725101V" in Journal of the Serbian Chemical Society (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3545 .

TY  - JOUR
AU  - Vilipić, Jovana
AU  - Novaković, Irena T.
AU  - Zlatović, Mario
AU  - Vujčić, Miroslava
AU  - Tufegdžić, Srđan
AU  - Sladić, Dušan
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2389
AB  - The interactions of nine amino acid derivatives of tert-butylquinone with biomacromolecules were studied. Sodium dodecyl sulphate (SDS) gel electrophoresis and mass spectrometry confirmed the absence of modifications of lysozyme by any of the synthesized compounds. Spectrophotometric studies demonstrated hyperchromism, i.e., the existence of interactions between the quinones and calf thymus DNA (CT-DNA). Determination of the binding constants by absorption titration indicated weak interactions between the quinone derivatives and CT-DNA. The quenching of fluorescence of the intercalator ethidium bromide (EB) from the EB-CT-DNA system and of the minor groove binder Hoechst 33258 (H) from the H-CT-DNA system by the synthesized derivatives indicated interactions of the compounds and CT-DNA. Circular dichroism (CD) spectra demonstrated a non-intercalative binding mode of the quinone derivatives to CT-DNA. Molecular docking results confirmed binding to the minor groove. The electrophoretic pattern showed no cleavage of the pUC19 plasmid in the presence of any of the synthesized compounds. The ability of the derivatives to scavenge radicals was confirmed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. All the presented results suggest that the DNA minor groove binding is the principal mechanism of action of the examined amino acid derivatives.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Interactions of cytotoxic amino acid derivatives of tert-butylquinone with DNA and lysozyme
VL  - 81
IS  - 12
SP  - 1345
EP  - 1358
DO  - 10.2298/JSC160725101V
ER  - 

@article{
author = "Vilipić, Jovana and Novaković, Irena T. and Zlatović, Mario and Vujčić, Miroslava and Tufegdžić, Srđan and Sladić, Dušan",
year = "2016",
abstract = "The interactions of nine amino acid derivatives of tert-butylquinone with biomacromolecules were studied. Sodium dodecyl sulphate (SDS) gel electrophoresis and mass spectrometry confirmed the absence of modifications of lysozyme by any of the synthesized compounds. Spectrophotometric studies demonstrated hyperchromism, i.e., the existence of interactions between the quinones and calf thymus DNA (CT-DNA). Determination of the binding constants by absorption titration indicated weak interactions between the quinone derivatives and CT-DNA. The quenching of fluorescence of the intercalator ethidium bromide (EB) from the EB-CT-DNA system and of the minor groove binder Hoechst 33258 (H) from the H-CT-DNA system by the synthesized derivatives indicated interactions of the compounds and CT-DNA. Circular dichroism (CD) spectra demonstrated a non-intercalative binding mode of the quinone derivatives to CT-DNA. Molecular docking results confirmed binding to the minor groove. The electrophoretic pattern showed no cleavage of the pUC19 plasmid in the presence of any of the synthesized compounds. The ability of the derivatives to scavenge radicals was confirmed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. All the presented results suggest that the DNA minor groove binding is the principal mechanism of action of the examined amino acid derivatives.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Interactions of cytotoxic amino acid derivatives of tert-butylquinone with DNA and lysozyme",
volume = "81",
number = "12",
pages = "1345-1358",
doi = "10.2298/JSC160725101V"
}

Vilipić, J., Novaković, I. T., Zlatović, M., Vujčić, M., Tufegdžić, S.,& Sladić, D.. (2016). Interactions of cytotoxic amino acid derivatives of tert-butylquinone with DNA and lysozyme. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 81(12), 1345-1358.
https://doi.org/10.2298/JSC160725101V

Vilipić J, Novaković IT, Zlatović M, Vujčić M, Tufegdžić S, Sladić D. Interactions of cytotoxic amino acid derivatives of tert-butylquinone with DNA and lysozyme. in Journal of the Serbian Chemical Society. 2016;81(12):1345-1358.
doi:10.2298/JSC160725101V .

Vilipić, Jovana, Novaković, Irena T., Zlatović, Mario, Vujčić, Miroslava, Tufegdžić, Srđan, Sladić, Dušan, "Interactions of cytotoxic amino acid derivatives of tert-butylquinone with DNA and lysozyme" in Journal of the Serbian Chemical Society, 81, no. 12 (2016):1345-1358,
https://doi.org/10.2298/JSC160725101V . .

TY  - JOUR
AU  - Vujčić, Miroslava
AU  - Tufegdžić, Srđan
AU  - Novaković, Irena T.
AU  - Djikanovic, Daniela
AU  - Gasic, Miroslav J.
AU  - Sladić, Dušan
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1484
AB  - The interactions of avarone, a quinone from the marine sponge Dysideaavara, and the methylamino derivatives of avarone (2), 3'-(methylamino)avarone (3) and 4'-(methylamino)avarone (4) with calf thymus DNA (CT-DNA) were studied. Agarose gel electrophoreticanalysis showed that binding of the quinones quenched fluorescence of ethidium bromide (EB). The extent of fluorescence quenching of intercalator EB by competitive displacement from EB-CT-DNA system and of groove binder Hoechst 33258 (H) from H-CT-DNA system with the quinones was analyzed by fluorescence spectroscopy. The obtained results demonstrated that the quinones reduced binding of both the intercalator EB and the minor groove binder H, indicating possible degradation of DNA. The substituent on the quinone moiety determined the extent of DNA damaging effect of the quinone, which was the most extensive with 3'-(methylamino)avarone and the least extensive with its regioisomer 4'-(methylamino)avarone. The results were confirmed by the observed hyperchromic effects in UV-visible spectra measured after interactions of the derivatives with CT-DNA.
PB  - Elsevier Science Bv, Amsterdam
T2  - International Journal of Biological Macromolecules
T1  - Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA
VL  - 62
SP  - 405
EP  - 410
DO  - 10.1016/j.ijbiomac.2013.09.013
ER  - 

@article{
author = "Vujčić, Miroslava and Tufegdžić, Srđan and Novaković, Irena T. and Djikanovic, Daniela and Gasic, Miroslav J. and Sladić, Dušan",
year = "2013",
abstract = "The interactions of avarone, a quinone from the marine sponge Dysideaavara, and the methylamino derivatives of avarone (2), 3'-(methylamino)avarone (3) and 4'-(methylamino)avarone (4) with calf thymus DNA (CT-DNA) were studied. Agarose gel electrophoreticanalysis showed that binding of the quinones quenched fluorescence of ethidium bromide (EB). The extent of fluorescence quenching of intercalator EB by competitive displacement from EB-CT-DNA system and of groove binder Hoechst 33258 (H) from H-CT-DNA system with the quinones was analyzed by fluorescence spectroscopy. The obtained results demonstrated that the quinones reduced binding of both the intercalator EB and the minor groove binder H, indicating possible degradation of DNA. The substituent on the quinone moiety determined the extent of DNA damaging effect of the quinone, which was the most extensive with 3'-(methylamino)avarone and the least extensive with its regioisomer 4'-(methylamino)avarone. The results were confirmed by the observed hyperchromic effects in UV-visible spectra measured after interactions of the derivatives with CT-DNA.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "International Journal of Biological Macromolecules",
title = "Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA",
volume = "62",
pages = "405-410",
doi = "10.1016/j.ijbiomac.2013.09.013"
}

Vujčić, M., Tufegdžić, S., Novaković, I. T., Djikanovic, D., Gasic, M. J.,& Sladić, D.. (2013). Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA. in International Journal of Biological Macromolecules
Elsevier Science Bv, Amsterdam., 62, 405-410.
https://doi.org/10.1016/j.ijbiomac.2013.09.013

Vujčić M, Tufegdžić S, Novaković IT, Djikanovic D, Gasic MJ, Sladić D. Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA. in International Journal of Biological Macromolecules. 2013;62:405-410.
doi:10.1016/j.ijbiomac.2013.09.013 .

Vujčić, Miroslava, Tufegdžić, Srđan, Novaković, Irena T., Djikanovic, Daniela, Gasic, Miroslav J., Sladić, Dušan, "Studies on the interactions of bioactive quinone avarone and its methylamino derivatives with calf thymus DNA" in International Journal of Biological Macromolecules, 62 (2013):405-410,
https://doi.org/10.1016/j.ijbiomac.2013.09.013 . .

TY  - CONF
AU  - Andjelkovic, U.
AU  - Pajic, I.
AU  - Vizovisek, M.
AU  - Vidmar, R.
AU  - Prislan, I.
AU  - Tufegdžić, Srđan
AU  - Fonovic, M.
AU  - Lah, J.
AU  - Turk, B.
AU  - Sladić, Dušan
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1419
PB  - Wiley-Blackwell, Hoboken
C3  - FEBS Journal / Federation of European of Biochemical Societies
T1  - A new lectin from coral Gerardia savaglia: purification, physico-chemical characterization and thermodynamics of saccharide binding
VL  - 280
SP  - 531
EP  - 531
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1419
ER  - 

@conference{
author = "Andjelkovic, U. and Pajic, I. and Vizovisek, M. and Vidmar, R. and Prislan, I. and Tufegdžić, Srđan and Fonovic, M. and Lah, J. and Turk, B. and Sladić, Dušan",
year = "2013",
publisher = "Wiley-Blackwell, Hoboken",
journal = "FEBS Journal / Federation of European of Biochemical Societies",
title = "A new lectin from coral Gerardia savaglia: purification, physico-chemical characterization and thermodynamics of saccharide binding",
volume = "280",
pages = "531-531",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1419"
}

Andjelkovic, U., Pajic, I., Vizovisek, M., Vidmar, R., Prislan, I., Tufegdžić, S., Fonovic, M., Lah, J., Turk, B.,& Sladić, D.. (2013). A new lectin from coral Gerardia savaglia: purification, physico-chemical characterization and thermodynamics of saccharide binding. in FEBS Journal / Federation of European of Biochemical Societies
Wiley-Blackwell, Hoboken., 280, 531-531.
https://hdl.handle.net/21.15107/rcub_cherry_1419

Andjelkovic U, Pajic I, Vizovisek M, Vidmar R, Prislan I, Tufegdžić S, Fonovic M, Lah J, Turk B, Sladić D. A new lectin from coral Gerardia savaglia: purification, physico-chemical characterization and thermodynamics of saccharide binding. in FEBS Journal / Federation of European of Biochemical Societies. 2013;280:531-531.
https://hdl.handle.net/21.15107/rcub_cherry_1419 .

Andjelkovic, U., Pajic, I., Vizovisek, M., Vidmar, R., Prislan, I., Tufegdžić, Srđan, Fonovic, M., Lah, J., Turk, B., Sladić, Dušan, "A new lectin from coral Gerardia savaglia: purification, physico-chemical characterization and thermodynamics of saccharide binding" in FEBS Journal / Federation of European of Biochemical Societies, 280 (2013):531-531,
https://hdl.handle.net/21.15107/rcub_cherry_1419 .

TY  - JOUR
AU  - Božić, Tatjana T.
AU  - Novaković, Irena T.
AU  - Gasic, Miroslav J.
AU  - Juranić, Zorica D.
AU  - Stanojković, Tatjana
AU  - Tufegdžić, Srđan
AU  - Kljajić, Zoran
AU  - Sladić, Dušan
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1057
AB  - Nine alkyl(aryl)thio derivatives of the marine sesquiterpene quinone avarone were synthesized by nucleophilic addition of thiols or thiophenol to avarone. In most cases only one regioisomer was obtained. Their cytotoxic activities, brine shrimp lethality and antibacterial activity were evaluated, as well as those of some previously synthesized avarone derivatives. Anti-HIV activity of two derivatives was tested. Electrochemical properties were determined for all the derivatives in Order to obtain more accurate information on structure-activity relationships. Most derivatives showed cytotoxic activity against tumor cell lines, with IC(50) values less than 10 mu M for some of them, in particular those with electron-donating substituents. The most active Compound was 4'-(methylamino)avarone, with IC(50) value of 2.4 mu M to melanoma Fem-X cells, and no cytotoxicity to normal lymphocytes. (C) 2009 Elsevier Masson SAS. All Fights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Synthesis and biological activity of derivatives of the marine quinone avarone
VL  - 45
IS  - 3
SP  - 923
EP  - 929
DO  - 10.1016/j.ejmech.2009.11.033
ER  - 

@article{
author = "Božić, Tatjana T. and Novaković, Irena T. and Gasic, Miroslav J. and Juranić, Zorica D. and Stanojković, Tatjana and Tufegdžić, Srđan and Kljajić, Zoran and Sladić, Dušan",
year = "2010",
abstract = "Nine alkyl(aryl)thio derivatives of the marine sesquiterpene quinone avarone were synthesized by nucleophilic addition of thiols or thiophenol to avarone. In most cases only one regioisomer was obtained. Their cytotoxic activities, brine shrimp lethality and antibacterial activity were evaluated, as well as those of some previously synthesized avarone derivatives. Anti-HIV activity of two derivatives was tested. Electrochemical properties were determined for all the derivatives in Order to obtain more accurate information on structure-activity relationships. Most derivatives showed cytotoxic activity against tumor cell lines, with IC(50) values less than 10 mu M for some of them, in particular those with electron-donating substituents. The most active Compound was 4'-(methylamino)avarone, with IC(50) value of 2.4 mu M to melanoma Fem-X cells, and no cytotoxicity to normal lymphocytes. (C) 2009 Elsevier Masson SAS. All Fights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis and biological activity of derivatives of the marine quinone avarone",
volume = "45",
number = "3",
pages = "923-929",
doi = "10.1016/j.ejmech.2009.11.033"
}

Božić, T. T., Novaković, I. T., Gasic, M. J., Juranić, Z. D., Stanojković, T., Tufegdžić, S., Kljajić, Z.,& Sladić, D.. (2010). Synthesis and biological activity of derivatives of the marine quinone avarone. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 45(3), 923-929.
https://doi.org/10.1016/j.ejmech.2009.11.033

Božić TT, Novaković IT, Gasic MJ, Juranić ZD, Stanojković T, Tufegdžić S, Kljajić Z, Sladić D. Synthesis and biological activity of derivatives of the marine quinone avarone. in European Journal of Medicinal Chemistry. 2010;45(3):923-929.
doi:10.1016/j.ejmech.2009.11.033 .

Božić, Tatjana T., Novaković, Irena T., Gasic, Miroslav J., Juranić, Zorica D., Stanojković, Tatjana, Tufegdžić, Srđan, Kljajić, Zoran, Sladić, Dušan, "Synthesis and biological activity of derivatives of the marine quinone avarone" in European Journal of Medicinal Chemistry, 45, no. 3 (2010):923-929,
https://doi.org/10.1016/j.ejmech.2009.11.033 . .

TY  - JOUR
AU  - Filipović, Nenad R.
AU  - Todorović, Tamara
AU  - Marković, Rade
AU  - Marinković, Aleksandar
AU  - Tufegdžić, Srđan
AU  - Gođevac, Dejan
AU  - Anđelković, Katarina K.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1099
AB  - Condensation derivatives of ethyl hydrazinoacetate with 2-formylpyridine and quinoline-2-carboxaldehyde were synthesized. Pd(II), Pt(II) and Cd(II) complexes with the 2-formylpyridine derivative and a Cd(II) complex with the quinoline-2-carboxaldehyde derivative were synthesized and characterized by spectroscopic techniques. In the complexes, both ligands are coordinated in neutral NN bidentate modes, while the remaining two coordination sites are occupied by chloride. All compounds showed biological activity when tested against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
PB  - Springer, Dordrecht
T2  - Transition Metal Chemistry
T1  - Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II)
VL  - 35
IS  - 6
SP  - 765
EP  - 772
DO  - 10.1007/s11243-010-9391-9
ER  - 

@article{
author = "Filipović, Nenad R. and Todorović, Tamara and Marković, Rade and Marinković, Aleksandar and Tufegdžić, Srđan and Gođevac, Dejan and Anđelković, Katarina K.",
year = "2010",
abstract = "Condensation derivatives of ethyl hydrazinoacetate with 2-formylpyridine and quinoline-2-carboxaldehyde were synthesized. Pd(II), Pt(II) and Cd(II) complexes with the 2-formylpyridine derivative and a Cd(II) complex with the quinoline-2-carboxaldehyde derivative were synthesized and characterized by spectroscopic techniques. In the complexes, both ligands are coordinated in neutral NN bidentate modes, while the remaining two coordination sites are occupied by chloride. All compounds showed biological activity when tested against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.",
publisher = "Springer, Dordrecht",
journal = "Transition Metal Chemistry",
title = "Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II)",
volume = "35",
number = "6",
pages = "765-772",
doi = "10.1007/s11243-010-9391-9"
}

Filipović, N. R., Todorović, T., Marković, R., Marinković, A., Tufegdžić, S., Gođevac, D.,& Anđelković, K. K.. (2010). Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II). in Transition Metal Chemistry
Springer, Dordrecht., 35(6), 765-772.
https://doi.org/10.1007/s11243-010-9391-9

Filipović NR, Todorović T, Marković R, Marinković A, Tufegdžić S, Gođevac D, Anđelković KK. Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II). in Transition Metal Chemistry. 2010;35(6):765-772.
doi:10.1007/s11243-010-9391-9 .

Filipović, Nenad R., Todorović, Tamara, Marković, Rade, Marinković, Aleksandar, Tufegdžić, Srđan, Gođevac, Dejan, Anđelković, Katarina K., "Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II)" in Transition Metal Chemistry, 35, no. 6 (2010):765-772,
https://doi.org/10.1007/s11243-010-9391-9 . .

TY  - JOUR
AU  - Vujčić, Miroslava
AU  - Tufegdžić, Srđan
AU  - Vujčić, Zoran
AU  - Gasic, Miroslav J.
AU  - Sladić, Dušan
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/905
AB  - Changes in electrophoresis pattern after interaction of supercoiled plasmid pBR322 DNA with avarol was studied at a micromolar concentration of reactants under mild reaction conditions. Interactions of avarol with linear high-molecular CT-DNA at millimolar concentrations were analyzed by electrophoresis and UV spectrophotometry. It was observed that avarol is capable of quenching ethidium bromide fluorescence in DNA bands. An increase in the absorbance of DNA was detected. The results indicate the binding of avarol to DNA and/or modification of nucleotide bases.
AB  - Proučavane su promene elektroforetskog ponašanja DNA posle interakcija superhelikoidalnog plazmida pBR322 s avarolom pri mikromolarnim koncentracijama reaktanata pod blagim reakcionim uslovima. Interakcije avarola sa linearnom visokomolekulskom CT-DNA pri milimolarnim koncentracijama analizirane su elektroforezom i UV spektrofotometrijom. Uočeno je da je avarol u stanju da gasi fluorescenciju etidijum-bromida u trakama koje potiču od DNA. Detektovan je porast apsorbancije DNA. Rezultati ukazuju na vezivanje avarona za DNA i/ili modifikaciju nukleotidnih baza.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Interactions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitro
T1  - Interakcije antitumorskog seskviterpenskog hidrohinona avarola sa DNA in vitro
VL  - 72
IS  - 12
SP  - 1265
EP  - 1269
DO  - 10.2298/JSC0712265V
ER  - 

@article{
author = "Vujčić, Miroslava and Tufegdžić, Srđan and Vujčić, Zoran and Gasic, Miroslav J. and Sladić, Dušan",
year = "2007",
abstract = "Changes in electrophoresis pattern after interaction of supercoiled plasmid pBR322 DNA with avarol was studied at a micromolar concentration of reactants under mild reaction conditions. Interactions of avarol with linear high-molecular CT-DNA at millimolar concentrations were analyzed by electrophoresis and UV spectrophotometry. It was observed that avarol is capable of quenching ethidium bromide fluorescence in DNA bands. An increase in the absorbance of DNA was detected. The results indicate the binding of avarol to DNA and/or modification of nucleotide bases., Proučavane su promene elektroforetskog ponašanja DNA posle interakcija superhelikoidalnog plazmida pBR322 s avarolom pri mikromolarnim koncentracijama reaktanata pod blagim reakcionim uslovima. Interakcije avarola sa linearnom visokomolekulskom CT-DNA pri milimolarnim koncentracijama analizirane su elektroforezom i UV spektrofotometrijom. Uočeno je da je avarol u stanju da gasi fluorescenciju etidijum-bromida u trakama koje potiču od DNA. Detektovan je porast apsorbancije DNA. Rezultati ukazuju na vezivanje avarona za DNA i/ili modifikaciju nukleotidnih baza.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Interactions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitro, Interakcije antitumorskog seskviterpenskog hidrohinona avarola sa DNA in vitro",
volume = "72",
number = "12",
pages = "1265-1269",
doi = "10.2298/JSC0712265V"
}

Vujčić, M., Tufegdžić, S., Vujčić, Z., Gasic, M. J.,& Sladić, D.. (2007). Interactions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitro. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 72(12), 1265-1269.
https://doi.org/10.2298/JSC0712265V

Vujčić M, Tufegdžić S, Vujčić Z, Gasic MJ, Sladić D. Interactions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitro. in Journal of the Serbian Chemical Society. 2007;72(12):1265-1269.
doi:10.2298/JSC0712265V .

Vujčić, Miroslava, Tufegdžić, Srđan, Vujčić, Zoran, Gasic, Miroslav J., Sladić, Dušan, "Interactions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitro" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1265-1269,
https://doi.org/10.2298/JSC0712265V . .