Spasić, Snežana

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Authority KeyName Variants
orcid::0000-0003-1731-3508
  • Spasić, Snežana (14)
Projects
Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology
FoodEnTwin-Twinning of research activities for the frontier research in the fields of food, nutrition and environmental omics Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance
Study of structure-function relationships in the plant cell wall and modifications of the wall structure by enzyme engineering Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products
Modulation of antioxidative metabolism in plants for improvement of plant abiotic stress tolerance and identification of new biomarkers for application in remediation and monitoring of degraded biotopes Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry)

Author's Bibliography

Investigation of pectin as a prebiotic, antioxidant and antimicrobial agent for the bacteria selected from human milk of mothers of premature infants

Lugonja, Nikoleta; Lončarević, Branka D.; Stanković, Dalibor; Marinković, Vesna S.; Lješević, Marija; Spasić, Snežana; Beškoski, Vladimir

(Turin : Edizioni Minerva Medica, 2021)

TY  - JOUR
AU  - Lugonja, Nikoleta
AU  - Lončarević, Branka D.
AU  - Stanković, Dalibor
AU  - Marinković, Vesna S.
AU  - Lješević, Marija
AU  - Spasić, Snežana
AU  - Beškoski, Vladimir
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4432
AB  - BACKGROUND: Pectin is a complex polysaccharide, present in fresh and processed food as an additive, which also serves as an important source of fiber. In this work, the aim was to investigate in-vitro application of apple pectin as a possible antimicrobial, antioxidant and prebiotic agent for growth of bacteria selected from human milk and infant feces, as well as standard strains Lactobacillus rhamnosus and Bifidobacterium bifidum.
METHODS : All the bacteria isolated from the milk of mothers of preterm and term-born infants, bacteria from infant feces and standard strains were tested for fermentation of apple pectin as the main carbohydrate in selective broth media.
RESULTS: An increase in the growth of bacteria Bifidobacteria, Lactobacillus, and a consortium of bacteria selected from human milk and infant feces was noticed after pectin fermentation. It was found that pectin has a positive impact on the increase of the antioxidant capacity in all the tested samples. A high correlation was achieved, comparing electrochemical with spectrophotometric methods. Antimicrobial tests showed that pectin and fermentation products have slight or no influence at all on the growth of standard strains of Escherichia coli, Staphylococcus aureus and Candida albicans.
CONCLUSIONS: The results showed the importance of pectin as an antioxidant and its impact on the development of potential probiotic microbiota in mothers and infants. The study indicated a new potential application of pectin as a supplement in infant food.
PB  - Turin : Edizioni Minerva Medica
T2  - Minerva Biotechnology and Biomolecular Research
T1  - Investigation of pectin as a prebiotic, antioxidant and antimicrobial agent for the bacteria selected from human milk of mothers of premature infants
VL  - 33
IS  - 2
SP  - 86
EP  - 92
DO  - 10.23736/S2724-542X.21.02760-9
ER  - 
@article{
author = "Lugonja, Nikoleta and Lončarević, Branka D. and Stanković, Dalibor and Marinković, Vesna S. and Lješević, Marija and Spasić, Snežana and Beškoski, Vladimir",
year = "2021",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4432",
abstract = "BACKGROUND: Pectin is a complex polysaccharide, present in fresh and processed food as an additive, which also serves as an important source of fiber. In this work, the aim was to investigate in-vitro application of apple pectin as a possible antimicrobial, antioxidant and prebiotic agent for growth of bacteria selected from human milk and infant feces, as well as standard strains Lactobacillus rhamnosus and Bifidobacterium bifidum.
METHODS : All the bacteria isolated from the milk of mothers of preterm and term-born infants, bacteria from infant feces and standard strains were tested for fermentation of apple pectin as the main carbohydrate in selective broth media.
RESULTS: An increase in the growth of bacteria Bifidobacteria, Lactobacillus, and a consortium of bacteria selected from human milk and infant feces was noticed after pectin fermentation. It was found that pectin has a positive impact on the increase of the antioxidant capacity in all the tested samples. A high correlation was achieved, comparing electrochemical with spectrophotometric methods. Antimicrobial tests showed that pectin and fermentation products have slight or no influence at all on the growth of standard strains of Escherichia coli, Staphylococcus aureus and Candida albicans.
CONCLUSIONS: The results showed the importance of pectin as an antioxidant and its impact on the development of potential probiotic microbiota in mothers and infants. The study indicated a new potential application of pectin as a supplement in infant food.",
publisher = "Turin : Edizioni Minerva Medica",
journal = "Minerva Biotechnology and Biomolecular Research",
title = "Investigation of pectin as a prebiotic, antioxidant and antimicrobial agent for the bacteria selected from human milk of mothers of premature infants",
volume = "33",
number = "2",
pages = "86-92",
doi = "10.23736/S2724-542X.21.02760-9"
}
Lugonja, N., Lončarević, B. D., Stanković, D., Marinković, V. S., Lješević, M., Spasić, S.,& Beškoski, V. (2021). Investigation of pectin as a prebiotic, antioxidant and antimicrobial agent for the bacteria selected from human milk of mothers of premature infants.
Minerva Biotechnology and Biomolecular Research
Turin : Edizioni Minerva Medica., 33(2), 86-92.
https://doi.org/10.23736/S2724-542X.21.02760-9
Lugonja N, Lončarević BD, Stanković D, Marinković VS, Lješević M, Spasić S, Beškoski V. Investigation of pectin as a prebiotic, antioxidant and antimicrobial agent for the bacteria selected from human milk of mothers of premature infants. Minerva Biotechnology and Biomolecular Research. 2021;33(2):86-92
Lugonja Nikoleta, Lončarević Branka D., Stanković Dalibor, Marinković Vesna S., Lješević Marija, Spasić Snežana, Beškoski Vladimir, "Investigation of pectin as a prebiotic, antioxidant and antimicrobial agent for the bacteria selected from human milk of mothers of premature infants" Minerva Biotechnology and Biomolecular Research, 33, no. 2 (2021):86-92,
https://doi.org/10.23736/S2724-542X.21.02760-9 .

Biliverdin-copper complex at physiological pH

Dimitrijević, Milena S.; Bogdanović Pristov, Jelena; Žižić, Milan; Stanković, Dalibor; Bajuk-Bogdanović, Danica; Stanić, Marina; Spasić, Snežana; Hagen, Wilfred; Spasojević, Ivan

(2019)

TY  - JOUR
AU  - Dimitrijević, Milena S.
AU  - Bogdanović Pristov, Jelena
AU  - Žižić, Milan
AU  - Stanković, Dalibor
AU  - Bajuk-Bogdanović, Danica
AU  - Stanić, Marina
AU  - Spasić, Snežana
AU  - Hagen, Wilfred
AU  - Spasojević, Ivan
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3068
AB  - Biliverdin (BV), a product of heme catabolism, is known to interact with transition metals, but the details of such interactions under physiological conditions are scarce. Herein, we examined coordinate/redox interactions of BV with Cu2+ in phosphate buffer at pH 7.4, using spectrophotometry, HESI-MS, Raman spectroscopy, 1 H NMR, EPR, fluorimetry, and electrochemical methods. BV formed a stable coordination complex with copper in 1 : 1 stoichiometry. The structure of BV was more planar and energetically stable in the complex. The complex showed strong paramagnetic effects that were attributed to an unpaired delocalized e−. The delocalized electron may come from BV or Cu2+, so the complex is formally composed either of BV radical cation and Cu1+ or of BV radical anion and Cu3+. The complex underwent oxidation only in the presence of both O2 and an excess of Cu2+, or a strong oxidizing agent, and it was resistant to reducing agents. The biological effects of the stable BV metallocomplex containing a delocalized unpaired electron should be further examined, and may provide an answer to the long-standing question of high energy investment in the catabolism of BV, which represents a relatively harmless molecule per se.
T2  - Dalton Transactions
T1  - Biliverdin-copper complex at physiological pH
VL  - 48
IS  - 18
SP  - 6061
EP  - 6070
DO  - 10.1039/c8dt04724c
ER  - 
@article{
author = "Dimitrijević, Milena S. and Bogdanović Pristov, Jelena and Žižić, Milan and Stanković, Dalibor and Bajuk-Bogdanović, Danica and Stanić, Marina and Spasić, Snežana and Hagen, Wilfred and Spasojević, Ivan",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3068",
abstract = "Biliverdin (BV), a product of heme catabolism, is known to interact with transition metals, but the details of such interactions under physiological conditions are scarce. Herein, we examined coordinate/redox interactions of BV with Cu2+ in phosphate buffer at pH 7.4, using spectrophotometry, HESI-MS, Raman spectroscopy, 1 H NMR, EPR, fluorimetry, and electrochemical methods. BV formed a stable coordination complex with copper in 1 : 1 stoichiometry. The structure of BV was more planar and energetically stable in the complex. The complex showed strong paramagnetic effects that were attributed to an unpaired delocalized e−. The delocalized electron may come from BV or Cu2+, so the complex is formally composed either of BV radical cation and Cu1+ or of BV radical anion and Cu3+. The complex underwent oxidation only in the presence of both O2 and an excess of Cu2+, or a strong oxidizing agent, and it was resistant to reducing agents. The biological effects of the stable BV metallocomplex containing a delocalized unpaired electron should be further examined, and may provide an answer to the long-standing question of high energy investment in the catabolism of BV, which represents a relatively harmless molecule per se.",
journal = "Dalton Transactions",
title = "Biliverdin-copper complex at physiological pH",
volume = "48",
number = "18",
pages = "6061-6070",
doi = "10.1039/c8dt04724c"
}
Dimitrijević, M. S., Bogdanović Pristov, J., Žižić, M., Stanković, D., Bajuk-Bogdanović, D., Stanić, M., Spasić, S., Hagen, W.,& Spasojević, I. (2019). Biliverdin-copper complex at physiological pH.
Dalton Transactions, 48(18), 6061-6070.
https://doi.org/10.1039/c8dt04724c
Dimitrijević MS, Bogdanović Pristov J, Žižić M, Stanković D, Bajuk-Bogdanović D, Stanić M, Spasić S, Hagen W, Spasojević I. Biliverdin-copper complex at physiological pH. Dalton Transactions. 2019;48(18):6061-6070
Dimitrijević Milena S., Bogdanović Pristov Jelena, Žižić Milan, Stanković Dalibor, Bajuk-Bogdanović Danica, Stanić Marina, Spasić Snežana, Hagen Wilfred, Spasojević Ivan, "Biliverdin-copper complex at physiological pH" Dalton Transactions, 48, no. 18 (2019):6061-6070,
https://doi.org/10.1039/c8dt04724c .
7
6
6

Supplementary data for article: Dimitrijević, M. S.; Bogdanović Pristov, J.; Žižić, M.; Stanković, D. M.; Bajuk-Bogdanović, D.; Stanić, M.; Spasić, S.; Hagen, W.; Spasojević, I. Biliverdin-Copper Complex at Physiological PH. Dalton Transactions 2019, 48 (18), 6061–6070. https://doi.org/10.1039/c8dt04724c

Dimitrijević, Milena S.; Bogdanović Pristov, Jelena; Žižić, Milan; Stanković, Dalibor; Bajuk-Bogdanović, Danica; Stanić, Marina; Spasić, Snežana; Hagen, Wilfred; Spasojević, Ivan

(2019)

TY  - BOOK
AU  - Dimitrijević, Milena S.
AU  - Bogdanović Pristov, Jelena
AU  - Žižić, Milan
AU  - Stanković, Dalibor
AU  - Bajuk-Bogdanović, Danica
AU  - Stanić, Marina
AU  - Spasić, Snežana
AU  - Hagen, Wilfred
AU  - Spasojević, Ivan
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3069
T2  - Dalton Transactions
T1  - Supplementary data for article:
Dimitrijević, M. S.; Bogdanović Pristov, J.; Žižić, M.; Stanković, D. M.; Bajuk-Bogdanović, D.; Stanić, M.; Spasić, S.; Hagen, W.; Spasojević, I. Biliverdin-Copper Complex at Physiological PH. Dalton Transactions 2019, 48 (18), 6061–6070. https://doi.org/10.1039/c8dt04724c
VL  - 48
IS  - 18
SP  - 6061
EP  - 6070
ER  - 
@book{
author = "Dimitrijević, Milena S. and Bogdanović Pristov, Jelena and Žižić, Milan and Stanković, Dalibor and Bajuk-Bogdanović, Danica and Stanić, Marina and Spasić, Snežana and Hagen, Wilfred and Spasojević, Ivan",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3069",
journal = "Dalton Transactions",
title = "Supplementary data for article:
Dimitrijević, M. S.; Bogdanović Pristov, J.; Žižić, M.; Stanković, D. M.; Bajuk-Bogdanović, D.; Stanić, M.; Spasić, S.; Hagen, W.; Spasojević, I. Biliverdin-Copper Complex at Physiological PH. Dalton Transactions 2019, 48 (18), 6061–6070. https://doi.org/10.1039/c8dt04724c",
volume = "48",
number = "18",
pages = "6061-6070"
}
Dimitrijević, M. S., Bogdanović Pristov, J., Žižić, M., Stanković, D., Bajuk-Bogdanović, D., Stanić, M., Spasić, S., Hagen, W.,& Spasojević, I. (2019). Supplementary data for article:
Dimitrijević, M. S.; Bogdanović Pristov, J.; Žižić, M.; Stanković, D. M.; Bajuk-Bogdanović, D.; Stanić, M.; Spasić, S.; Hagen, W.; Spasojević, I. Biliverdin-Copper Complex at Physiological PH. Dalton Transactions 2019, 48 (18), 6061–6070. https://doi.org/10.1039/c8dt04724c.
Dalton Transactions, 48(18), 6061-6070.
Dimitrijević MS, Bogdanović Pristov J, Žižić M, Stanković D, Bajuk-Bogdanović D, Stanić M, Spasić S, Hagen W, Spasojević I. Supplementary data for article:
Dimitrijević, M. S.; Bogdanović Pristov, J.; Žižić, M.; Stanković, D. M.; Bajuk-Bogdanović, D.; Stanić, M.; Spasić, S.; Hagen, W.; Spasojević, I. Biliverdin-Copper Complex at Physiological PH. Dalton Transactions 2019, 48 (18), 6061–6070. https://doi.org/10.1039/c8dt04724c. Dalton Transactions. 2019;48(18):6061-6070
Dimitrijević Milena S., Bogdanović Pristov Jelena, Žižić Milan, Stanković Dalibor, Bajuk-Bogdanović Danica, Stanić Marina, Spasić Snežana, Hagen Wilfred, Spasojević Ivan, "Supplementary data for article:
Dimitrijević, M. S.; Bogdanović Pristov, J.; Žižić, M.; Stanković, D. M.; Bajuk-Bogdanović, D.; Stanić, M.; Spasić, S.; Hagen, W.; Spasojević, I. Biliverdin-Copper Complex at Physiological PH. Dalton Transactions 2019, 48 (18), 6061–6070. https://doi.org/10.1039/c8dt04724c" Dalton Transactions, 48, no. 18 (2019):6061-6070

Biliverdin-copper complex at physiological pH

Dimitrijević, Milena S.; Bogdanović Pristov, Jelena; Žižić, Milan; Stanković, Dalibor; Bajuk-Bogdanović, Danica; Stanić, Marina; Spasić, Snežana; Hagen, Wilfred; Spasojević, Ivan

(2019)

TY  - JOUR
AU  - Dimitrijević, Milena S.
AU  - Bogdanović Pristov, Jelena
AU  - Žižić, Milan
AU  - Stanković, Dalibor
AU  - Bajuk-Bogdanović, Danica
AU  - Stanić, Marina
AU  - Spasić, Snežana
AU  - Hagen, Wilfred
AU  - Spasojević, Ivan
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3066
AB  - Biliverdin (BV), a product of heme catabolism, is known to interact with transition metals, but the details of such interactions under physiological conditions are scarce. Herein, we examined coordinate/redox interactions of BV with Cu2+ in phosphate buffer at pH 7.4, using spectrophotometry, HESI-MS, Raman spectroscopy, 1 H NMR, EPR, fluorimetry, and electrochemical methods. BV formed a stable coordination complex with copper in 1 : 1 stoichiometry. The structure of BV was more planar and energetically stable in the complex. The complex showed strong paramagnetic effects that were attributed to an unpaired delocalized e−. The delocalized electron may come from BV or Cu2+, so the complex is formally composed either of BV radical cation and Cu1+ or of BV radical anion and Cu3+. The complex underwent oxidation only in the presence of both O2 and an excess of Cu2+, or a strong oxidizing agent, and it was resistant to reducing agents. The biological effects of the stable BV metallocomplex containing a delocalized unpaired electron should be further examined, and may provide an answer to the long-standing question of high energy investment in the catabolism of BV, which represents a relatively harmless molecule per se.
T2  - Dalton Transactions
T1  - Biliverdin-copper complex at physiological pH
VL  - 48
IS  - 18
SP  - 6061
EP  - 6070
DO  - 10.1039/c8dt04724c
ER  - 
@article{
author = "Dimitrijević, Milena S. and Bogdanović Pristov, Jelena and Žižić, Milan and Stanković, Dalibor and Bajuk-Bogdanović, Danica and Stanić, Marina and Spasić, Snežana and Hagen, Wilfred and Spasojević, Ivan",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3066",
abstract = "Biliverdin (BV), a product of heme catabolism, is known to interact with transition metals, but the details of such interactions under physiological conditions are scarce. Herein, we examined coordinate/redox interactions of BV with Cu2+ in phosphate buffer at pH 7.4, using spectrophotometry, HESI-MS, Raman spectroscopy, 1 H NMR, EPR, fluorimetry, and electrochemical methods. BV formed a stable coordination complex with copper in 1 : 1 stoichiometry. The structure of BV was more planar and energetically stable in the complex. The complex showed strong paramagnetic effects that were attributed to an unpaired delocalized e−. The delocalized electron may come from BV or Cu2+, so the complex is formally composed either of BV radical cation and Cu1+ or of BV radical anion and Cu3+. The complex underwent oxidation only in the presence of both O2 and an excess of Cu2+, or a strong oxidizing agent, and it was resistant to reducing agents. The biological effects of the stable BV metallocomplex containing a delocalized unpaired electron should be further examined, and may provide an answer to the long-standing question of high energy investment in the catabolism of BV, which represents a relatively harmless molecule per se.",
journal = "Dalton Transactions",
title = "Biliverdin-copper complex at physiological pH",
volume = "48",
number = "18",
pages = "6061-6070",
doi = "10.1039/c8dt04724c"
}
Dimitrijević, M. S., Bogdanović Pristov, J., Žižić, M., Stanković, D., Bajuk-Bogdanović, D., Stanić, M., Spasić, S., Hagen, W.,& Spasojević, I. (2019). Biliverdin-copper complex at physiological pH.
Dalton Transactions, 48(18), 6061-6070.
https://doi.org/10.1039/c8dt04724c
Dimitrijević MS, Bogdanović Pristov J, Žižić M, Stanković D, Bajuk-Bogdanović D, Stanić M, Spasić S, Hagen W, Spasojević I. Biliverdin-copper complex at physiological pH. Dalton Transactions. 2019;48(18):6061-6070
Dimitrijević Milena S., Bogdanović Pristov Jelena, Žižić Milan, Stanković Dalibor, Bajuk-Bogdanović Danica, Stanić Marina, Spasić Snežana, Hagen Wilfred, Spasojević Ivan, "Biliverdin-copper complex at physiological pH" Dalton Transactions, 48, no. 18 (2019):6061-6070,
https://doi.org/10.1039/c8dt04724c .
7
6
6

Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content

Uzelac, Tamara N.; Nikolić-Kokić, Aleksandra; Spasić, Snežana; Mačvanin, Mirjana T.; Nikolić, Milan; Mandić, Ljuba M.; Jovanović, Vesna B.

(2019)

TY  - JOUR
AU  - Uzelac, Tamara N.
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Snežana
AU  - Mačvanin, Mirjana T.
AU  - Nikolić, Milan
AU  - Mandić, Ljuba M.
AU  - Jovanović, Vesna B.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3333
AB  - Antipsychotic drugs interfere with the antioxidant defense system provoking complex and often toxicological effects. Here we examined differences in plasma albumin reduced free thiol (SH) group content and its reactivity as a consequence of clozapine (CLZ) and ziprasidone (ZIP) binding. Chronic administration of CLZ reduced, whereas treatment with ZIP increased albumin-SH content in rats. Regardless of the ratio of stearic acid (SA) bound to protein, in vitro binding of ZIP to human serum albumin (HSA) increased both the SH group level and reactivity. In contrast, the effect of CLZ on HSA-SH reactivity was dependent on HSA to SA molar ratio. CLZ binding was accompanied by an increase in HSA-SH reactivity in samples with normal, but a reduction of its reactivity level with higher SA/HSA ratio, compared to drug-free samples. We demonstrate by steady-state fluorescence quenching studies that an increase in SA binding to HSA is associated with a significant reduction of binding constant for both antipsychotics. In addition, this is the first report of quantitative characterization of ZIP binding to HSA. Our findings suggest that albumin-SH content and reactivity is modulated by ZIP towards an increased antioxidant defense capacity in circulation, as opposed to CLZ, which can contribute to the safer, more effective treatment of schizophrenia.
T2  - Chemico-Biological Interactions
T1  - Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content
VL  - 311
SP  - 1
EP  - 7
DO  - 10.1016/j.cbi.2019.108787
ER  - 
@article{
author = "Uzelac, Tamara N. and Nikolić-Kokić, Aleksandra and Spasić, Snežana and Mačvanin, Mirjana T. and Nikolić, Milan and Mandić, Ljuba M. and Jovanović, Vesna B.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3333",
abstract = "Antipsychotic drugs interfere with the antioxidant defense system provoking complex and often toxicological effects. Here we examined differences in plasma albumin reduced free thiol (SH) group content and its reactivity as a consequence of clozapine (CLZ) and ziprasidone (ZIP) binding. Chronic administration of CLZ reduced, whereas treatment with ZIP increased albumin-SH content in rats. Regardless of the ratio of stearic acid (SA) bound to protein, in vitro binding of ZIP to human serum albumin (HSA) increased both the SH group level and reactivity. In contrast, the effect of CLZ on HSA-SH reactivity was dependent on HSA to SA molar ratio. CLZ binding was accompanied by an increase in HSA-SH reactivity in samples with normal, but a reduction of its reactivity level with higher SA/HSA ratio, compared to drug-free samples. We demonstrate by steady-state fluorescence quenching studies that an increase in SA binding to HSA is associated with a significant reduction of binding constant for both antipsychotics. In addition, this is the first report of quantitative characterization of ZIP binding to HSA. Our findings suggest that albumin-SH content and reactivity is modulated by ZIP towards an increased antioxidant defense capacity in circulation, as opposed to CLZ, which can contribute to the safer, more effective treatment of schizophrenia.",
journal = "Chemico-Biological Interactions",
title = "Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content",
volume = "311",
pages = "1-7",
doi = "10.1016/j.cbi.2019.108787"
}
Uzelac, T. N., Nikolić-Kokić, A., Spasić, S., Mačvanin, M. T., Nikolić, M., Mandić, L. M.,& Jovanović, V. B. (2019). Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content.
Chemico-Biological Interactions, 311, 1-7.
https://doi.org/10.1016/j.cbi.2019.108787
Uzelac TN, Nikolić-Kokić A, Spasić S, Mačvanin MT, Nikolić M, Mandić LM, Jovanović VB. Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content. Chemico-Biological Interactions. 2019;311:1-7
Uzelac Tamara N., Nikolić-Kokić Aleksandra, Spasić Snežana, Mačvanin Mirjana T., Nikolić Milan, Mandić Ljuba M., Jovanović Vesna B., "Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content" Chemico-Biological Interactions, 311 (2019):1-7,
https://doi.org/10.1016/j.cbi.2019.108787 .

Supplementary data for the article: Uzelac, T. N.; Nikolić-Kokić, A. L.; Spasić, S. D.; Mačvanin, M. T.; Nikolić, M. R.; Mandić, L. M.; Jovanović, V. B. Opposite Clozapine and Ziprasidone Effects on the Reactivity of Plasma Albumin SH-Group Are the Consequence of Their Different Binding Properties Dependent on Protein Fatty Acids Content. Chemico-Biological Interactions 2019, 311. https://doi.org/10.1016/j.cbi.2019.108787

Uzelac, Tamara N.; Nikolić-Kokić, Aleksandra; Spasić, Snežana; Mačvanin, Mirjana T.; Nikolić, Milan; Mandić, Ljuba M.; Jovanović, Vesna B.

(2019)

TY  - BOOK
AU  - Uzelac, Tamara N.
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Snežana
AU  - Mačvanin, Mirjana T.
AU  - Nikolić, Milan
AU  - Mandić, Ljuba M.
AU  - Jovanović, Vesna B.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3335
T2  - Chemico-Biological Interactions
T1  - Supplementary data for the article: Uzelac, T. N.; Nikolić-Kokić, A. L.; Spasić, S. D.; Mačvanin, M. T.; Nikolić, M. R.; Mandić, L. M.; Jovanović, V. B. Opposite Clozapine and Ziprasidone Effects on the Reactivity of Plasma Albumin SH-Group Are the Consequence of Their Different Binding Properties Dependent on Protein Fatty Acids Content. Chemico-Biological Interactions 2019, 311. https://doi.org/10.1016/j.cbi.2019.108787
ER  - 
@book{
author = "Uzelac, Tamara N. and Nikolić-Kokić, Aleksandra and Spasić, Snežana and Mačvanin, Mirjana T. and Nikolić, Milan and Mandić, Ljuba M. and Jovanović, Vesna B.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3335",
journal = "Chemico-Biological Interactions",
title = "Supplementary data for the article: Uzelac, T. N.; Nikolić-Kokić, A. L.; Spasić, S. D.; Mačvanin, M. T.; Nikolić, M. R.; Mandić, L. M.; Jovanović, V. B. Opposite Clozapine and Ziprasidone Effects on the Reactivity of Plasma Albumin SH-Group Are the Consequence of Their Different Binding Properties Dependent on Protein Fatty Acids Content. Chemico-Biological Interactions 2019, 311. https://doi.org/10.1016/j.cbi.2019.108787"
}
Uzelac, T. N., Nikolić-Kokić, A., Spasić, S., Mačvanin, M. T., Nikolić, M., Mandić, L. M.,& Jovanović, V. B. (2019). Supplementary data for the article: Uzelac, T. N.; Nikolić-Kokić, A. L.; Spasić, S. D.; Mačvanin, M. T.; Nikolić, M. R.; Mandić, L. M.; Jovanović, V. B. Opposite Clozapine and Ziprasidone Effects on the Reactivity of Plasma Albumin SH-Group Are the Consequence of Their Different Binding Properties Dependent on Protein Fatty Acids Content. Chemico-Biological Interactions 2019, 311. https://doi.org/10.1016/j.cbi.2019.108787.
Chemico-Biological Interactions.
Uzelac TN, Nikolić-Kokić A, Spasić S, Mačvanin MT, Nikolić M, Mandić LM, Jovanović VB. Supplementary data for the article: Uzelac, T. N.; Nikolić-Kokić, A. L.; Spasić, S. D.; Mačvanin, M. T.; Nikolić, M. R.; Mandić, L. M.; Jovanović, V. B. Opposite Clozapine and Ziprasidone Effects on the Reactivity of Plasma Albumin SH-Group Are the Consequence of Their Different Binding Properties Dependent on Protein Fatty Acids Content. Chemico-Biological Interactions 2019, 311. https://doi.org/10.1016/j.cbi.2019.108787. Chemico-Biological Interactions. 2019;
Uzelac Tamara N., Nikolić-Kokić Aleksandra, Spasić Snežana, Mačvanin Mirjana T., Nikolić Milan, Mandić Ljuba M., Jovanović Vesna B., "Supplementary data for the article: Uzelac, T. N.; Nikolić-Kokić, A. L.; Spasić, S. D.; Mačvanin, M. T.; Nikolić, M. R.; Mandić, L. M.; Jovanović, V. B. Opposite Clozapine and Ziprasidone Effects on the Reactivity of Plasma Albumin SH-Group Are the Consequence of Their Different Binding Properties Dependent on Protein Fatty Acids Content. Chemico-Biological Interactions 2019, 311. https://doi.org/10.1016/j.cbi.2019.108787" Chemico-Biological Interactions (2019)

Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content

Uzelac, Tamara N.; Nikolić-Kokić, Aleksandra; Spasić, Snežana; Mačvanin, Mirjana T.; Nikolić, Milan; Mandić, Ljuba M.; Jovanović, Vesna B.

(Elsevier, 2019)

TY  - JOUR
AU  - Uzelac, Tamara N.
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Snežana
AU  - Mačvanin, Mirjana T.
AU  - Nikolić, Milan
AU  - Mandić, Ljuba M.
AU  - Jovanović, Vesna B.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3865
AB  - Antipsychotic drugs interfere with the antioxidant defense system provoking complex and often toxicological effects. Here we examined differences in plasma albumin reduced free thiol (SH) group content and its reactivity as a consequence of clozapine (CLZ) and ziprasidone (ZIP) binding. Chronic administration of CLZ reduced, whereas treatment with ZIP increased albumin-SH content in rats. Regardless of the ratio of stearic acid (SA) bound to protein, in vitro binding of ZIP to human serum albumin (HSA) increased both the SH group level and reactivity. In contrast, the effect of CLZ on HSA-SH reactivity was dependent on HSA to SA molar ratio. CLZ binding was accompanied by an increase in HSA-SH reactivity in samples with normal, but a reduction of its reactivity level with higher SA/HSA ratio, compared to drug-free samples. We demonstrate by steady-state fluorescence quenching studies that an increase in SA binding to HSA is associated with a significant reduction of binding constant for both antipsychotics. In addition, this is the first report of quantitative characterization of ZIP binding to HSA. Our findings suggest that albumin-SH content and reactivity is modulated by ZIP towards an increased antioxidant defense capacity in circulation, as opposed to CLZ, which can contribute to the safer, more effective treatment of schizophrenia.
PB  - Elsevier
T2  - Chemico-Biological Interactions
T1  - Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content
VL  - 311
IS  - 108787
DO  - 10.1016/j.cbi.2019.108787
ER  - 
@article{
author = "Uzelac, Tamara N. and Nikolić-Kokić, Aleksandra and Spasić, Snežana and Mačvanin, Mirjana T. and Nikolić, Milan and Mandić, Ljuba M. and Jovanović, Vesna B.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3865",
abstract = "Antipsychotic drugs interfere with the antioxidant defense system provoking complex and often toxicological effects. Here we examined differences in plasma albumin reduced free thiol (SH) group content and its reactivity as a consequence of clozapine (CLZ) and ziprasidone (ZIP) binding. Chronic administration of CLZ reduced, whereas treatment with ZIP increased albumin-SH content in rats. Regardless of the ratio of stearic acid (SA) bound to protein, in vitro binding of ZIP to human serum albumin (HSA) increased both the SH group level and reactivity. In contrast, the effect of CLZ on HSA-SH reactivity was dependent on HSA to SA molar ratio. CLZ binding was accompanied by an increase in HSA-SH reactivity in samples with normal, but a reduction of its reactivity level with higher SA/HSA ratio, compared to drug-free samples. We demonstrate by steady-state fluorescence quenching studies that an increase in SA binding to HSA is associated with a significant reduction of binding constant for both antipsychotics. In addition, this is the first report of quantitative characterization of ZIP binding to HSA. Our findings suggest that albumin-SH content and reactivity is modulated by ZIP towards an increased antioxidant defense capacity in circulation, as opposed to CLZ, which can contribute to the safer, more effective treatment of schizophrenia.",
publisher = "Elsevier",
journal = "Chemico-Biological Interactions",
title = "Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content",
volume = "311",
number = "108787",
doi = "10.1016/j.cbi.2019.108787"
}
Uzelac, T. N., Nikolić-Kokić, A., Spasić, S., Mačvanin, M. T., Nikolić, M., Mandić, L. M.,& Jovanović, V. B. (2019). Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content.
Chemico-Biological Interactions
Elsevier., 311(108787).
https://doi.org/10.1016/j.cbi.2019.108787
Uzelac TN, Nikolić-Kokić A, Spasić S, Mačvanin MT, Nikolić M, Mandić LM, Jovanović VB. Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content. Chemico-Biological Interactions. 2019;311(108787)
Uzelac Tamara N., Nikolić-Kokić Aleksandra, Spasić Snežana, Mačvanin Mirjana T., Nikolić Milan, Mandić Ljuba M., Jovanović Vesna B., "Opposite clozapine and ziprasidone effects on the reactivity of plasma albumin SH-group are the consequence of their different binding properties dependent on protein fatty acids content" Chemico-Biological Interactions, 311, no. 108787 (2019),
https://doi.org/10.1016/j.cbi.2019.108787 .

Redox properties of transitional milk from mothers of preterm infants

Minić, Simeon L.; Ješić, Miloš; Đurović, Dijana; Miletić, Srđan B.; Lugonja, Nikoleta; Marinković, Vesna; Nikolić-Kokić, Aleksandra; Spasić, Snežana; Vrvić, Miroslav M.

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Minić, Simeon L.
AU  - Ješić, Miloš
AU  - Đurović, Dijana
AU  - Miletić, Srđan B.
AU  - Lugonja, Nikoleta
AU  - Marinković, Vesna
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Snežana
AU  - Vrvić, Miroslav M.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2084
AB  - AimThere is a discrepancy between the amount of transitional milk produced by mothers of preterm infants and the low capacity of premature infants to consume it. This milk can be used in milk banks, but previous studies found that there are large variations in the level of host-defence proteins in individual samples of milk from mothers of premature infants, which implies that large individual variations in antioxidative defence composition are also possible. MethodsMilk samples were collected from 20 healthy mothers of preterm infants. We determined the values for non-enzymatic antioxidative capacity parameters (oxygen radical absorbance capacity (ORAC)), static oxidation-reduction potential (ORP), activities of antioxidant defence enzymes and the amount of vitamin C in whole milk, skim and whey fractions of transitional milk. ResultsThe main low-molecular-weight antioxidant in transitional milk is vitamin C and most of it is contained in whey. ORAC is higher in whole transitional milk than in skim milk and whey, and ORP is lower in whole transitional milk than that in skim milk and whey. Antioxidative enzyme activities are similar in all individual samples of transitional milk from mothers of preterm infants. ConclusionsOur results indicate that transitional milk of mothers of preterm infants shows slow individual variations in antioxidative defence composition; therefore, it can be used in human milk banks.
PB  - Wiley, Hoboken
T2  - Journal of Paediatrics and Child Health
T1  - Redox properties of transitional milk from mothers of preterm infants
VL  - 54
IS  - 2
SP  - 160
EP  - 164
DO  - 10.1111/jpc.13676
ER  - 
@article{
author = "Minić, Simeon L. and Ješić, Miloš and Đurović, Dijana and Miletić, Srđan B. and Lugonja, Nikoleta and Marinković, Vesna and Nikolić-Kokić, Aleksandra and Spasić, Snežana and Vrvić, Miroslav M.",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2084",
abstract = "AimThere is a discrepancy between the amount of transitional milk produced by mothers of preterm infants and the low capacity of premature infants to consume it. This milk can be used in milk banks, but previous studies found that there are large variations in the level of host-defence proteins in individual samples of milk from mothers of premature infants, which implies that large individual variations in antioxidative defence composition are also possible. MethodsMilk samples were collected from 20 healthy mothers of preterm infants. We determined the values for non-enzymatic antioxidative capacity parameters (oxygen radical absorbance capacity (ORAC)), static oxidation-reduction potential (ORP), activities of antioxidant defence enzymes and the amount of vitamin C in whole milk, skim and whey fractions of transitional milk. ResultsThe main low-molecular-weight antioxidant in transitional milk is vitamin C and most of it is contained in whey. ORAC is higher in whole transitional milk than in skim milk and whey, and ORP is lower in whole transitional milk than that in skim milk and whey. Antioxidative enzyme activities are similar in all individual samples of transitional milk from mothers of preterm infants. ConclusionsOur results indicate that transitional milk of mothers of preterm infants shows slow individual variations in antioxidative defence composition; therefore, it can be used in human milk banks.",
publisher = "Wiley, Hoboken",
journal = "Journal of Paediatrics and Child Health",
title = "Redox properties of transitional milk from mothers of preterm infants",
volume = "54",
number = "2",
pages = "160-164",
doi = "10.1111/jpc.13676"
}
Minić, S. L., Ješić, M., Đurović, D., Miletić, S. B., Lugonja, N., Marinković, V., Nikolić-Kokić, A., Spasić, S.,& Vrvić, M. M. (2018). Redox properties of transitional milk from mothers of preterm infants.
Journal of Paediatrics and Child Health
Wiley, Hoboken., 54(2), 160-164.
https://doi.org/10.1111/jpc.13676
Minić SL, Ješić M, Đurović D, Miletić SB, Lugonja N, Marinković V, Nikolić-Kokić A, Spasić S, Vrvić MM. Redox properties of transitional milk from mothers of preterm infants. Journal of Paediatrics and Child Health. 2018;54(2):160-164
Minić Simeon L., Ješić Miloš, Đurović Dijana, Miletić Srđan B., Lugonja Nikoleta, Marinković Vesna, Nikolić-Kokić Aleksandra, Spasić Snežana, Vrvić Miroslav M., "Redox properties of transitional milk from mothers of preterm infants" Journal of Paediatrics and Child Health, 54, no. 2 (2018):160-164,
https://doi.org/10.1111/jpc.13676 .
4
2
1
3

Electrochemical monitoring of the breast milk quality

Lugonja, Nikoleta; Stanković, Dalibor; Miličić, Biljana; Spasić, Snežana; Marinković, Vesna; Vrvić, Miroslav M.

(Elsevier Sci Ltd, Oxford, 2018)

TY  - JOUR
AU  - Lugonja, Nikoleta
AU  - Stanković, Dalibor
AU  - Miličić, Biljana
AU  - Spasić, Snežana
AU  - Marinković, Vesna
AU  - Vrvić, Miroslav M.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2528
AB  - The electrochemical techniques were used to determine the total antioxidant capacity of breast milks and the results were compared with a commonly used spectrophotometric (2,2-diphenyl-1-picrylhydrazyl, DPPH) method. Breast milk from mothers of preterm infants was monitored in three lactation phases and after storage of expressed milk by monitoring changes in the total antioxidant capacity over a two year period. Statistical analysis showed there was no significant difference between the ability of the three methods to detect changes in breast milk after storage. Either of the electrochemical techniques studied could be successfully used to replace the time-consuming spectrophotometric method and can be applied to clinical trials.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Electrochemical monitoring of the breast milk quality
VL  - 240
SP  - 567
EP  - 572
DO  - 10.1016/j.foodchem.2017.07.164
ER  - 
@article{
author = "Lugonja, Nikoleta and Stanković, Dalibor and Miličić, Biljana and Spasić, Snežana and Marinković, Vesna and Vrvić, Miroslav M.",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2528",
abstract = "The electrochemical techniques were used to determine the total antioxidant capacity of breast milks and the results were compared with a commonly used spectrophotometric (2,2-diphenyl-1-picrylhydrazyl, DPPH) method. Breast milk from mothers of preterm infants was monitored in three lactation phases and after storage of expressed milk by monitoring changes in the total antioxidant capacity over a two year period. Statistical analysis showed there was no significant difference between the ability of the three methods to detect changes in breast milk after storage. Either of the electrochemical techniques studied could be successfully used to replace the time-consuming spectrophotometric method and can be applied to clinical trials.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Electrochemical monitoring of the breast milk quality",
volume = "240",
pages = "567-572",
doi = "10.1016/j.foodchem.2017.07.164"
}
Lugonja, N., Stanković, D., Miličić, B., Spasić, S., Marinković, V.,& Vrvić, M. M. (2018). Electrochemical monitoring of the breast milk quality.
Food Chemistry
Elsevier Sci Ltd, Oxford., 240, 567-572.
https://doi.org/10.1016/j.foodchem.2017.07.164
Lugonja N, Stanković D, Miličić B, Spasić S, Marinković V, Vrvić MM. Electrochemical monitoring of the breast milk quality. Food Chemistry. 2018;240:567-572
Lugonja Nikoleta, Stanković Dalibor, Miličić Biljana, Spasić Snežana, Marinković Vesna, Vrvić Miroslav M., "Electrochemical monitoring of the breast milk quality" Food Chemistry, 240 (2018):567-572,
https://doi.org/10.1016/j.foodchem.2017.07.164 .
8
4
9

Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity

Božić, Bojana; Korać, Jelena; Stanković, Dalibor; Stanić, Marina; Romanović, Mima; Pristov-Bogdanović, Jelena; Spasić, Snežana; Popović-Bijelić, Ana; Spasojević, Ivan; Bajčetić, Milica

(Elsevier, 2018)

TY  - JOUR
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Pristov-Bogdanović, Jelena
AU  - Spasić, Snežana
AU  - Popović-Bijelić, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/349
AB  - An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis. © 2018 Elsevier Inc.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
VL  - 129
SP  - 279
EP  - 285
DO  - 10.1016/j.freeradbiomed.2018.09.038
ER  - 
@article{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor and Stanić, Marina and Romanović, Mima and Pristov-Bogdanović, Jelena and Spasić, Snežana and Popović-Bijelić, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/349",
abstract = "An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis. © 2018 Elsevier Inc.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity",
volume = "129",
pages = "279-285",
doi = "10.1016/j.freeradbiomed.2018.09.038"
}
Božić, B., Korać, J., Stanković, D., Stanić, M., Romanović, M., Pristov-Bogdanović, J., Spasić, S., Popović-Bijelić, A., Spasojević, I.,& Bajčetić, M. (2018). Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity.
Free Radical Biology and Medicine
Elsevier., 129, 279-285.
https://doi.org/10.1016/j.freeradbiomed.2018.09.038
Božić B, Korać J, Stanković D, Stanić M, Romanović M, Pristov-Bogdanović J, Spasić S, Popović-Bijelić A, Spasojević I, Bajčetić M. Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. Free Radical Biology and Medicine. 2018;129:279-285
Božić Bojana, Korać Jelena, Stanković Dalibor, Stanić Marina, Romanović Mima, Pristov-Bogdanović Jelena, Spasić Snežana, Popović-Bijelić Ana, Spasojević Ivan, Bajčetić Milica, "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity" Free Radical Biology and Medicine, 129 (2018):279-285,
https://doi.org/10.1016/j.freeradbiomed.2018.09.038 .
1
2
1
3

Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity

Božić, Bojana; Korać, Jelena; Stanković, Dalibor; Stanić, Marina; Romanović, Mima; Pristov-Bogdanović, Jelena; Spasić, Snežana; Popović-Bijelić, Ana; Spasojević, Ivan; Bajčetić, Milica

(Elsevier, 2018)

TY  - JOUR
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Pristov-Bogdanović, Jelena
AU  - Spasić, Snežana
AU  - Popović-Bijelić, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2940
AB  - An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis. © 2018 Elsevier Inc.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
VL  - 129
SP  - 279
EP  - 285
DO  - 10.1016/j.freeradbiomed.2018.09.038
ER  - 
@article{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor and Stanić, Marina and Romanović, Mima and Pristov-Bogdanović, Jelena and Spasić, Snežana and Popović-Bijelić, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2940",
abstract = "An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis. © 2018 Elsevier Inc.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity",
volume = "129",
pages = "279-285",
doi = "10.1016/j.freeradbiomed.2018.09.038"
}
Božić, B., Korać, J., Stanković, D., Stanić, M., Romanović, M., Pristov-Bogdanović, J., Spasić, S., Popović-Bijelić, A., Spasojević, I.,& Bajčetić, M. (2018). Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity.
Free Radical Biology and Medicine
Elsevier., 129, 279-285.
https://doi.org/10.1016/j.freeradbiomed.2018.09.038
Božić B, Korać J, Stanković D, Stanić M, Romanović M, Pristov-Bogdanović J, Spasić S, Popović-Bijelić A, Spasojević I, Bajčetić M. Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. Free Radical Biology and Medicine. 2018;129:279-285
Božić Bojana, Korać Jelena, Stanković Dalibor, Stanić Marina, Romanović Mima, Pristov-Bogdanović Jelena, Spasić Snežana, Popović-Bijelić Ana, Spasojević Ivan, Bajčetić Milica, "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity" Free Radical Biology and Medicine, 129 (2018):279-285,
https://doi.org/10.1016/j.freeradbiomed.2018.09.038 .
1
2
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Supplementary data for the article: Božić, B.; Korać, J.; Stanković, D. M.; Stanić, M.; Romanović, M.; Pristov, J. B.; Spasić, S.; Popović-Bijelić, A.; Spasojević, I.; Bajčetić, M. Coordination and Redox Interactions of β-Lactam Antibiotics with Cu2+ in Physiological Settings and the Impact on Antibacterial Activity. Free Radical Biology and Medicine 2018, 129, 279–285. https://doi.org/10.1016/j.freeradbiomed.2018.09.038

Božić, Bojana; Korać, Jelena; Stanković, Dalibor; Stanić, Marina; Romanović, Mima; Pristov-Bogdanović, Jelena; Spasić, Snežana; Popović-Bijelić, Ana; Spasojević, Ivan; Bajčetić, Milica

(2018)

TY  - BOOK
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Pristov-Bogdanović, Jelena
AU  - Spasić, Snežana
AU  - Popović-Bijelić, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2941
T2  - Free Radical Biology and Medicine
T1  - Supplementary data for the article: Božić, B.; Korać, J.; Stanković, D. M.; Stanić, M.; Romanović, M.; Pristov, J. B.; Spasić, S.; Popović-Bijelić, A.; Spasojević, I.; Bajčetić, M. Coordination and Redox Interactions of β-Lactam Antibiotics with Cu2+ in Physiological Settings and the Impact on Antibacterial Activity. Free Radical Biology and Medicine 2018, 129, 279–285. https://doi.org/10.1016/j.freeradbiomed.2018.09.038
VL  - 129
SP  - 279
EP  - 285
ER  - 
@book{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor and Stanić, Marina and Romanović, Mima and Pristov-Bogdanović, Jelena and Spasić, Snežana and Popović-Bijelić, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2941",
journal = "Free Radical Biology and Medicine",
title = "Supplementary data for the article: Božić, B.; Korać, J.; Stanković, D. M.; Stanić, M.; Romanović, M.; Pristov, J. B.; Spasić, S.; Popović-Bijelić, A.; Spasojević, I.; Bajčetić, M. Coordination and Redox Interactions of β-Lactam Antibiotics with Cu2+ in Physiological Settings and the Impact on Antibacterial Activity. Free Radical Biology and Medicine 2018, 129, 279–285. https://doi.org/10.1016/j.freeradbiomed.2018.09.038",
volume = "129",
pages = "279-285"
}
Božić, B., Korać, J., Stanković, D., Stanić, M., Romanović, M., Pristov-Bogdanović, J., Spasić, S., Popović-Bijelić, A., Spasojević, I.,& Bajčetić, M. (2018). Supplementary data for the article: Božić, B.; Korać, J.; Stanković, D. M.; Stanić, M.; Romanović, M.; Pristov, J. B.; Spasić, S.; Popović-Bijelić, A.; Spasojević, I.; Bajčetić, M. Coordination and Redox Interactions of β-Lactam Antibiotics with Cu2+ in Physiological Settings and the Impact on Antibacterial Activity. Free Radical Biology and Medicine 2018, 129, 279–285. https://doi.org/10.1016/j.freeradbiomed.2018.09.038.
Free Radical Biology and Medicine, 129, 279-285.
Božić B, Korać J, Stanković D, Stanić M, Romanović M, Pristov-Bogdanović J, Spasić S, Popović-Bijelić A, Spasojević I, Bajčetić M. Supplementary data for the article: Božić, B.; Korać, J.; Stanković, D. M.; Stanić, M.; Romanović, M.; Pristov, J. B.; Spasić, S.; Popović-Bijelić, A.; Spasojević, I.; Bajčetić, M. Coordination and Redox Interactions of β-Lactam Antibiotics with Cu2+ in Physiological Settings and the Impact on Antibacterial Activity. Free Radical Biology and Medicine 2018, 129, 279–285. https://doi.org/10.1016/j.freeradbiomed.2018.09.038. Free Radical Biology and Medicine. 2018;129:279-285
Božić Bojana, Korać Jelena, Stanković Dalibor, Stanić Marina, Romanović Mima, Pristov-Bogdanović Jelena, Spasić Snežana, Popović-Bijelić Ana, Spasojević Ivan, Bajčetić Milica, "Supplementary data for the article: Božić, B.; Korać, J.; Stanković, D. M.; Stanić, M.; Romanović, M.; Pristov, J. B.; Spasić, S.; Popović-Bijelić, A.; Spasojević, I.; Bajčetić, M. Coordination and Redox Interactions of β-Lactam Antibiotics with Cu2+ in Physiological Settings and the Impact on Antibacterial Activity. Free Radical Biology and Medicine 2018, 129, 279–285. https://doi.org/10.1016/j.freeradbiomed.2018.09.038" Free Radical Biology and Medicine, 129 (2018):279-285

Comparative Electrochemical Determination of Total Antioxidant Activity in Infant Formula with Breast Milk

Lugonja, Nikoleta; Stanković, Dalibor; Spasić, Snežana; Roglić, Goran; Manojlović, Dragan D.; Vrvić, Miroslav M.

(Springer, New York, 2014)

TY  - JOUR
AU  - Lugonja, Nikoleta
AU  - Stanković, Dalibor
AU  - Spasić, Snežana
AU  - Roglić, Goran
AU  - Manojlović, Dragan D.
AU  - Vrvić, Miroslav M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1487
AB  - The aim of this study is to investigate the significance of breast milk and infant formula in the prevention of oxidative stress, by electrochemical determination of the total antioxidant potential, demonstrating the relationship between the antioxidant capacity of milk and postnatal age. Human breast milk, commercial UHT milk, and infant formulas supplemented with prebiotics were used. Samples were diluted in phosphate buffer solution, and the total antioxidant activity was potentiometrically measured by the iodine/iodide redox couple with the Pt Fisher electrode as a working electrode and saturated calomel as a reference electrode. Cyclic voltammograms and differential pulse voltammograms were recorded with the glassy carbon electrode as the working electrode, an accessory platinum electrode, and an Ag/AgCl reference electrode. The potentiometric measurement indicates that human breast milk has the highest redox potential, while the commercial UHT milk has very low potential. Infant formulas also have high potential. The main advantage of electrochemical methods used to assess the total antioxidant activity of milk was that they directly monitored the electron-donating ability of the compounds and could be used for the quantitative analysis of the total antioxidants of different types of milk.
PB  - Springer, New York
T2  - Food Analytical Methods
T1  - Comparative Electrochemical Determination of Total Antioxidant Activity in Infant Formula with Breast Milk
VL  - 7
IS  - 2
SP  - 337
EP  - 344
DO  - 10.1007/s12161-013-9631-7
ER  - 
@article{
author = "Lugonja, Nikoleta and Stanković, Dalibor and Spasić, Snežana and Roglić, Goran and Manojlović, Dragan D. and Vrvić, Miroslav M.",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1487",
abstract = "The aim of this study is to investigate the significance of breast milk and infant formula in the prevention of oxidative stress, by electrochemical determination of the total antioxidant potential, demonstrating the relationship between the antioxidant capacity of milk and postnatal age. Human breast milk, commercial UHT milk, and infant formulas supplemented with prebiotics were used. Samples were diluted in phosphate buffer solution, and the total antioxidant activity was potentiometrically measured by the iodine/iodide redox couple with the Pt Fisher electrode as a working electrode and saturated calomel as a reference electrode. Cyclic voltammograms and differential pulse voltammograms were recorded with the glassy carbon electrode as the working electrode, an accessory platinum electrode, and an Ag/AgCl reference electrode. The potentiometric measurement indicates that human breast milk has the highest redox potential, while the commercial UHT milk has very low potential. Infant formulas also have high potential. The main advantage of electrochemical methods used to assess the total antioxidant activity of milk was that they directly monitored the electron-donating ability of the compounds and could be used for the quantitative analysis of the total antioxidants of different types of milk.",
publisher = "Springer, New York",
journal = "Food Analytical Methods",
title = "Comparative Electrochemical Determination of Total Antioxidant Activity in Infant Formula with Breast Milk",
volume = "7",
number = "2",
pages = "337-344",
doi = "10.1007/s12161-013-9631-7"
}
Lugonja, N., Stanković, D., Spasić, S., Roglić, G., Manojlović, D. D.,& Vrvić, M. M. (2014). Comparative Electrochemical Determination of Total Antioxidant Activity in Infant Formula with Breast Milk.
Food Analytical Methods
Springer, New York., 7(2), 337-344.
https://doi.org/10.1007/s12161-013-9631-7
Lugonja N, Stanković D, Spasić S, Roglić G, Manojlović DD, Vrvić MM. Comparative Electrochemical Determination of Total Antioxidant Activity in Infant Formula with Breast Milk. Food Analytical Methods. 2014;7(2):337-344
Lugonja Nikoleta, Stanković Dalibor, Spasić Snežana, Roglić Goran, Manojlović Dragan D., Vrvić Miroslav M., "Comparative Electrochemical Determination of Total Antioxidant Activity in Infant Formula with Breast Milk" Food Analytical Methods, 7, no. 2 (2014):337-344,
https://doi.org/10.1007/s12161-013-9631-7 .
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The Effect of Humic Acids on Zymogenous Microbial Consortia Growth

Miletić, Srđan B.; Spasić, Snežana; Avdalović, Jelena; Beškoski, Vladimir; Ilić, Mila V.; Gojgić-Cvijović, Gordana D.; Vrvić, Miroslav M.

(Wiley-Blackwell, Hoboken, 2014)

TY  - JOUR
AU  - Miletić, Srđan B.
AU  - Spasić, Snežana
AU  - Avdalović, Jelena
AU  - Beškoski, Vladimir
AU  - Ilić, Mila V.
AU  - Gojgić-Cvijović, Gordana D.
AU  - Vrvić, Miroslav M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1852
AB  - This paper describes experiments with standard humic acids (HA-S) and humic acids (HA) isolated from soil that was contaminated with mazut and treated with a consortium of microorganisms for the process of bioremediation (HA-E). Both acids inhibited the toxicity of ferric chloride and increased the growth of a zymogenous microbial consortia compared with controls. Electron paramagnetic resonance spectroscopy showed that HA-S and HA-E exhibit high anti-oxidative activity involving free radical scavenging and iron sequestration. HA additionally promote microbial consortium growth by providing protection from oxidative stress.
PB  - Wiley-Blackwell, Hoboken
T2  - CLEAN - Soil Air Water
T1  - The Effect of Humic Acids on Zymogenous Microbial Consortia Growth
VL  - 42
IS  - 9
SP  - 1280
EP  - 1283
DO  - 10.1002/clen.201300034
ER  - 
@article{
author = "Miletić, Srđan B. and Spasić, Snežana and Avdalović, Jelena and Beškoski, Vladimir and Ilić, Mila V. and Gojgić-Cvijović, Gordana D. and Vrvić, Miroslav M.",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1852",
abstract = "This paper describes experiments with standard humic acids (HA-S) and humic acids (HA) isolated from soil that was contaminated with mazut and treated with a consortium of microorganisms for the process of bioremediation (HA-E). Both acids inhibited the toxicity of ferric chloride and increased the growth of a zymogenous microbial consortia compared with controls. Electron paramagnetic resonance spectroscopy showed that HA-S and HA-E exhibit high anti-oxidative activity involving free radical scavenging and iron sequestration. HA additionally promote microbial consortium growth by providing protection from oxidative stress.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "CLEAN - Soil Air Water",
title = "The Effect of Humic Acids on Zymogenous Microbial Consortia Growth",
volume = "42",
number = "9",
pages = "1280-1283",
doi = "10.1002/clen.201300034"
}
Miletić, S. B., Spasić, S., Avdalović, J., Beškoski, V., Ilić, M. V., Gojgić-Cvijović, G. D.,& Vrvić, M. M. (2014). The Effect of Humic Acids on Zymogenous Microbial Consortia Growth.
CLEAN - Soil Air Water
Wiley-Blackwell, Hoboken., 42(9), 1280-1283.
https://doi.org/10.1002/clen.201300034
Miletić SB, Spasić S, Avdalović J, Beškoski V, Ilić MV, Gojgić-Cvijović GD, Vrvić MM. The Effect of Humic Acids on Zymogenous Microbial Consortia Growth. CLEAN - Soil Air Water. 2014;42(9):1280-1283
Miletić Srđan B., Spasić Snežana, Avdalović Jelena, Beškoski Vladimir, Ilić Mila V., Gojgić-Cvijović Gordana D., Vrvić Miroslav M., "The Effect of Humic Acids on Zymogenous Microbial Consortia Growth" CLEAN - Soil Air Water, 42, no. 9 (2014):1280-1283,
https://doi.org/10.1002/clen.201300034 .
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