Stojsavljević, Aleksandar

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orcid::0000-0002-6221-3437
  • Stojsavljević, Aleksandar (17)
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Author's Bibliography

Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus

Vujotić, Ljiljana; Matić, Siniša; Borković-Mitić, Slavica; Stojsavljević, Aleksandar; Mutić, Jelena; Baščarević, Vladimir; Joković, Miloš; Pavlović, Slađan Z.

(Termedia Publishing House, 2020)

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković-Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan Z.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3982
AB  - Introduction: Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus. Material and methods: Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe. Results: The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor. Conclusions: There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia Publishing House
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
VL  - 16
IS  - 4
SP  - 811
EP  - 819
DO  - 10.5114/aoms.2019.87409
ER  - 
@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković-Mitić, Slavica and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan Z.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3982",
abstract = "Introduction: Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus. Material and methods: Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe. Results: The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor. Conclusions: There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia Publishing House",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
volume = "16",
number = "4",
pages = "811-819",
doi = "10.5114/aoms.2019.87409"
}
Vujotić, L., Matić, S., Borković-Mitić, S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S. Z. (2020). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus.
Archives of Medical Science
Termedia Publishing House., 16(4), 811-819.
https://doi.org/10.5114/aoms.2019.87409
Vujotić L, Matić S, Borković-Mitić S, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović SZ. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. Archives of Medical Science. 2020;16(4):811-819
Vujotić Ljiljana, Matić Siniša, Borković-Mitić Slavica, Stojsavljević Aleksandar, Mutić Jelena, Baščarević Vladimir, Joković Miloš, Pavlović Slađan Z., "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" Archives of Medical Science, 16, no. 4 (2020):811-819,
https://doi.org/10.5114/aoms.2019.87409 .
2
1
1

Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Borković-Mitić, Slavica S.; Paunović, Ivan; Diklić, Aleksandar; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(2020)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Diklić, Aleksandar
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3955
AB  - The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlight its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].
T2  - Exposure and Health
T1  - Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease
VL  - 12
IS  - 2
SP  - 255
EP  - 264
DO  - 10.1007/s12403-019-00309-9
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Diklić, Aleksandar and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3955",
abstract = "The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlight its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].",
journal = "Exposure and Health",
title = "Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease",
volume = "12",
number = "2",
pages = "255-264",
doi = "10.1007/s12403-019-00309-9"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Diklić, A., Gavrović-Jankulović, M.,& Manojlović, D. D. (2020). Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease.
Exposure and Health, 12(2), 255-264.
https://doi.org/10.1007/s12403-019-00309-9
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Diklić A, Gavrović-Jankulović M, Manojlović DD. Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease. Exposure and Health. 2020;12(2):255-264
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Borković-Mitić Slavica S., Paunović Ivan, Diklić Aleksandar, Gavrović-Jankulović Marija, Manojlović Dragan D., "Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease" Exposure and Health, 12, no. 2 (2020):255-264,
https://doi.org/10.1007/s12403-019-00309-9 .
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Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević, Aleksandar; Vujotić, Ljiljana; Rovčanin, Branislav; Borković-Mitić, Slavica S.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Nature Research, 2020)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Vujotić, Ljiljana
AU  - Rovčanin, Branislav
AU  - Borković-Mitić, Slavica S.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3885
AB  - The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.
PB  - Nature Research
T2  - Scientific Reports
T1  - Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors
VL  - 10
IS  - 1
DO  - 10.1038/s41598-020-60774-0
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Vujotić, Ljiljana and Rovčanin, Branislav and Borković-Mitić, Slavica S. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3885",
abstract = "The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors",
volume = "10",
number = "1",
doi = "10.1038/s41598-020-60774-0"
}
Stojsavljević, A., Vujotić, L., Rovčanin, B., Borković-Mitić, S. S., Gavrović-Jankulović, M.,& Manojlović, D. D. (2020). Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors.
Scientific Reports
Nature Research., 10(1).
https://doi.org/10.1038/s41598-020-60774-0
Stojsavljević A, Vujotić L, Rovčanin B, Borković-Mitić SS, Gavrović-Jankulović M, Manojlović DD. Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors. Scientific Reports. 2020;10(1)
Stojsavljević Aleksandar, Vujotić Ljiljana, Rovčanin Branislav, Borković-Mitić Slavica S., Gavrović-Jankulović Marija, Manojlović Dragan D., "Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors" Scientific Reports, 10, no. 1 (2020),
https://doi.org/10.1038/s41598-020-60774-0 .
6
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Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples

Stojsavljević, Aleksandar; Rovčanin, Branislav; Jagodić, Jovana; Drašković Radojković, Danijela; Paunović, Ivan; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2020)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Jagodić, Jovana
AU  - Drašković Radojković, Danijela
AU  - Paunović, Ivan
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4032
AB  - Our previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relevant parameters that could affect the concentration of trace elements were considered. This research showed that there was a difference in the elemental profile between HT and control samples. The most important findings were related to the elevated As and Pb content in the thyroid tissue and HT blood samples. The obtained negative correlations between As and Pb with Se may explain the antagonistic effect of As and Pb on the extrusion of essential Se from the HT tissue. The reduced Se content in the blood and its increased content in urine samples may further confirm this hypothesis and explain the lack of Se in HT. Furthermore, the reported results may highlight the unresolved molecular basis of HT and could indicate the role of trace element effects on thyroid homeostasis.
PB  - Elsevier
T2  - Environmental Research
T1  - Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples
VL  - 186
SP  - 109538
DO  - 10.1016/j.envres.2020.109538
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Jagodić, Jovana and Drašković Radojković, Danijela and Paunović, Ivan and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4032",
abstract = "Our previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relevant parameters that could affect the concentration of trace elements were considered. This research showed that there was a difference in the elemental profile between HT and control samples. The most important findings were related to the elevated As and Pb content in the thyroid tissue and HT blood samples. The obtained negative correlations between As and Pb with Se may explain the antagonistic effect of As and Pb on the extrusion of essential Se from the HT tissue. The reduced Se content in the blood and its increased content in urine samples may further confirm this hypothesis and explain the lack of Se in HT. Furthermore, the reported results may highlight the unresolved molecular basis of HT and could indicate the role of trace element effects on thyroid homeostasis.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples",
volume = "186",
pages = "109538",
doi = "10.1016/j.envres.2020.109538"
}
Stojsavljević, A., Rovčanin, B., Jagodić, J., Drašković Radojković, D., Paunović, I., Gavrović-Jankulović, M.,& Manojlović, D. D. (2020). Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples.
Environmental Research
Elsevier., 186, 109538.
https://doi.org/10.1016/j.envres.2020.109538
Stojsavljević A, Rovčanin B, Jagodić J, Drašković Radojković D, Paunović I, Gavrović-Jankulović M, Manojlović DD. Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples. Environmental Research. 2020;186:109538
Stojsavljević Aleksandar, Rovčanin Branislav, Jagodić Jovana, Drašković Radojković Danijela, Paunović Ivan, Gavrović-Jankulović Marija, Manojlović Dragan D., "Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples" Environmental Research, 186 (2020):109538,
https://doi.org/10.1016/j.envres.2020.109538 .
5
1
5

Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter

Rovčanin, Branislav; Stojsavljević, Aleksandar; Kekić, Dušan; Gopčević, Kristina; Manojlović, Dragan D.; Jovanović, Milan; Knežević, Saša; Živaljević, Vladan; Diklić, Aleksandar; Paunovic, Ivan

(2020)

TY  - JOUR
AU  - Rovčanin, Branislav
AU  - Stojsavljević, Aleksandar
AU  - Kekić, Dušan
AU  - Gopčević, Kristina
AU  - Manojlović, Dragan D.
AU  - Jovanović, Milan
AU  - Knežević, Saša
AU  - Živaljević, Vladan
AU  - Diklić, Aleksandar
AU  - Paunovic, Ivan
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4282
AB  - Papillary thyroid carcinoma (PTC) is the endocrine neoplasm that occurs the most often worldwide, and its molecular pathophysiology is still not well characterized. Redox status is recognized as an important factor of carcinogenesis, but its influence on the PTC's clinical course needs to be better elucidated. The aim of this research was to determine the tissue redox status of 65 PTC and 45 colloid goiter (CG) patients together with antioxidative cofactor metal profiling. The malondialdehyde (MDA) concentration was used to access the prooxidation level, while antioxidant mechanisms were estimated by assaying the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). The antioxidative cofactor metals included quantification of Se, Cu, Zn, and Mn concentration. PTC tissues had normal prooxidation levels and increased GPx and GR activity. The activity of SOD has been significantly reduced in multicentric PTC dissemination and increased in smokers. SOD activity was directly dependent on MDA levels in CG tissues. CG patients with retrosternal goiter had reduced MDA concentration and SOD activity. Numerous correlations between redox parameters in PTC tissues reveal good co-activation of antioxidative mechanisms and cooperative response on prooxidation. PTC tissues had decreased Se levels and increased concentration of Cu and Mn in comparison to other tissues. MDA concentration and SOD activity were significant predictors of PTC's multicentric dissemination and for the existence of lymph node metastases, respectively. Particularly, the concentration of Cu predicted the retrosternal localization in CG patients. Significant findings presented in this study provide a possibility for development of novel prognostic molecular biomarkers of PTC and CG.
T2  - Biological Trace Element Research
T1  - Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter
VL  - 197
IS  - 2
SP  - 349
EP  - 359
DO  - 10.1007/s12011-019-01995-x
ER  - 
@article{
author = "Rovčanin, Branislav and Stojsavljević, Aleksandar and Kekić, Dušan and Gopčević, Kristina and Manojlović, Dragan D. and Jovanović, Milan and Knežević, Saša and Živaljević, Vladan and Diklić, Aleksandar and Paunovic, Ivan",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4282",
abstract = "Papillary thyroid carcinoma (PTC) is the endocrine neoplasm that occurs the most often worldwide, and its molecular pathophysiology is still not well characterized. Redox status is recognized as an important factor of carcinogenesis, but its influence on the PTC's clinical course needs to be better elucidated. The aim of this research was to determine the tissue redox status of 65 PTC and 45 colloid goiter (CG) patients together with antioxidative cofactor metal profiling. The malondialdehyde (MDA) concentration was used to access the prooxidation level, while antioxidant mechanisms were estimated by assaying the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). The antioxidative cofactor metals included quantification of Se, Cu, Zn, and Mn concentration. PTC tissues had normal prooxidation levels and increased GPx and GR activity. The activity of SOD has been significantly reduced in multicentric PTC dissemination and increased in smokers. SOD activity was directly dependent on MDA levels in CG tissues. CG patients with retrosternal goiter had reduced MDA concentration and SOD activity. Numerous correlations between redox parameters in PTC tissues reveal good co-activation of antioxidative mechanisms and cooperative response on prooxidation. PTC tissues had decreased Se levels and increased concentration of Cu and Mn in comparison to other tissues. MDA concentration and SOD activity were significant predictors of PTC's multicentric dissemination and for the existence of lymph node metastases, respectively. Particularly, the concentration of Cu predicted the retrosternal localization in CG patients. Significant findings presented in this study provide a possibility for development of novel prognostic molecular biomarkers of PTC and CG.",
journal = "Biological Trace Element Research",
title = "Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter",
volume = "197",
number = "2",
pages = "349-359",
doi = "10.1007/s12011-019-01995-x"
}
Rovčanin, B., Stojsavljević, A., Kekić, D., Gopčević, K., Manojlović, D. D., Jovanović, M., Knežević, S., Živaljević, V., Diklić, A.,& Paunovic, I. (2020). Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter.
Biological Trace Element Research, 197(2), 349-359.
https://doi.org/10.1007/s12011-019-01995-x
Rovčanin B, Stojsavljević A, Kekić D, Gopčević K, Manojlović DD, Jovanović M, Knežević S, Živaljević V, Diklić A, Paunovic I. Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter. Biological Trace Element Research. 2020;197(2):349-359
Rovčanin Branislav, Stojsavljević Aleksandar, Kekić Dušan, Gopčević Kristina, Manojlović Dragan D., Jovanović Milan, Knežević Saša, Živaljević Vladan, Diklić Aleksandar, Paunovic Ivan, "Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter" Biological Trace Element Research, 197, no. 2 (2020):349-359,
https://doi.org/10.1007/s12011-019-01995-x .
1
1
1

Correction to: Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter (Biological Trace Element Research, (2020), 197, 2, (349-359), 10.1007/s12011-019-01995-x)

Rovčanin, Branislav; Stojsavljević, Aleksandar; Kekić, Dušan; Gopčević, Kristina; Manojlović, Dragan D.; Jovanović, Milan; Knežević, Saša; Živaljević, Vladan; Diklić, Aleksandar; Paunovic, Ivan

(Springer, 2020)

TY  - JOUR
AU  - Rovčanin, Branislav
AU  - Stojsavljević, Aleksandar
AU  - Kekić, Dušan
AU  - Gopčević, Kristina
AU  - Manojlović, Dragan D.
AU  - Jovanović, Milan
AU  - Knežević, Saša
AU  - Živaljević, Vladan
AU  - Diklić, Aleksandar
AU  - Paunovic, Ivan
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4283
AB  - Papillary thyroid carcinoma (PTC) is the endocrine neoplasm that occurs the most often worldwide, and its molecular pathophysiology is still not well characterized. Redox status is recognized as an important factor of carcinogenesis, but its influence on the PTC's clinical course needs to be better elucidated. The aim of this research was to determine the tissue redox status of 65 PTC and 45 colloid goiter (CG) patients together with antioxidative cofactor metal profiling. The malondialdehyde (MDA) concentration was used to access the prooxidation level, while antioxidant mechanisms were estimated by assaying the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). The antioxidative cofactor metals included quantification of Se, Cu, Zn, and Mn concentration. PTC tissues had normal prooxidation levels and increased GPx and GR activity. The activity of SOD has been significantly reduced in multicentric PTC dissemination and increased in smokers. SOD activity was directly dependent on MDA levels in CG tissues. CG patients with retrosternal goiter had reduced MDA concentration and SOD activity. Numerous correlations between redox parameters in PTC tissues reveal good co-activation of antioxidative mechanisms and cooperative response on prooxidation. PTC tissues had decreased Se levels and increased concentration of Cu and Mn in comparison to other tissues. MDA concentration and SOD activity were significant predictors of PTC's multicentric dissemination and for the existence of lymph node metastases, respectively. Particularly, the concentration of Cu predicted the retrosternal localization in CG patients. Significant findings presented in this study provide a possibility for development of novel prognostic molecular biomarkers of PTC and CG.
PB  - Springer
T2  - Biological Trace Element Research
T1  - Correction to: Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter (Biological Trace Element Research, (2020), 197, 2, (349-359), 10.1007/s12011-019-01995-x)
VL  - 197
IS  - 2
SP  - 349
EP  - 359
DO  - 10.1007/s12011-019-01995-x
ER  - 
@article{
author = "Rovčanin, Branislav and Stojsavljević, Aleksandar and Kekić, Dušan and Gopčević, Kristina and Manojlović, Dragan D. and Jovanović, Milan and Knežević, Saša and Živaljević, Vladan and Diklić, Aleksandar and Paunovic, Ivan",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4283",
abstract = "Papillary thyroid carcinoma (PTC) is the endocrine neoplasm that occurs the most often worldwide, and its molecular pathophysiology is still not well characterized. Redox status is recognized as an important factor of carcinogenesis, but its influence on the PTC's clinical course needs to be better elucidated. The aim of this research was to determine the tissue redox status of 65 PTC and 45 colloid goiter (CG) patients together with antioxidative cofactor metal profiling. The malondialdehyde (MDA) concentration was used to access the prooxidation level, while antioxidant mechanisms were estimated by assaying the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). The antioxidative cofactor metals included quantification of Se, Cu, Zn, and Mn concentration. PTC tissues had normal prooxidation levels and increased GPx and GR activity. The activity of SOD has been significantly reduced in multicentric PTC dissemination and increased in smokers. SOD activity was directly dependent on MDA levels in CG tissues. CG patients with retrosternal goiter had reduced MDA concentration and SOD activity. Numerous correlations between redox parameters in PTC tissues reveal good co-activation of antioxidative mechanisms and cooperative response on prooxidation. PTC tissues had decreased Se levels and increased concentration of Cu and Mn in comparison to other tissues. MDA concentration and SOD activity were significant predictors of PTC's multicentric dissemination and for the existence of lymph node metastases, respectively. Particularly, the concentration of Cu predicted the retrosternal localization in CG patients. Significant findings presented in this study provide a possibility for development of novel prognostic molecular biomarkers of PTC and CG.",
publisher = "Springer",
journal = "Biological Trace Element Research",
title = "Correction to: Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter (Biological Trace Element Research, (2020), 197, 2, (349-359), 10.1007/s12011-019-01995-x)",
volume = "197",
number = "2",
pages = "349-359",
doi = "10.1007/s12011-019-01995-x"
}
Rovčanin, B., Stojsavljević, A., Kekić, D., Gopčević, K., Manojlović, D. D., Jovanović, M., Knežević, S., Živaljević, V., Diklić, A.,& Paunovic, I. (2020). Correction to: Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter (Biological Trace Element Research, (2020), 197, 2, (349-359), 10.1007/s12011-019-01995-x).
Biological Trace Element Research
Springer., 197(2), 349-359.
https://doi.org/10.1007/s12011-019-01995-x
Rovčanin B, Stojsavljević A, Kekić D, Gopčević K, Manojlović DD, Jovanović M, Knežević S, Živaljević V, Diklić A, Paunovic I. Correction to: Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter (Biological Trace Element Research, (2020), 197, 2, (349-359), 10.1007/s12011-019-01995-x). Biological Trace Element Research. 2020;197(2):349-359
Rovčanin Branislav, Stojsavljević Aleksandar, Kekić Dušan, Gopčević Kristina, Manojlović Dragan D., Jovanović Milan, Knežević Saša, Živaljević Vladan, Diklić Aleksandar, Paunovic Ivan, "Correction to: Redox Status and Antioxidative Cofactor Metals Influence Clinical and Pathological Characteristics of Papillary Thyroid Carcinoma and Colloid Goiter (Biological Trace Element Research, (2020), 197, 2, (349-359), 10.1007/s12011-019-01995-x)" Biological Trace Element Research, 197, no. 2 (2020):349-359,
https://doi.org/10.1007/s12011-019-01995-x .
1
1

A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)

Pavlović, Slađan; Krizmanić, Imre; Borković-Mitić, Slavica; Stojsavljević, Aleksandar; Mitić, Bojan

(Belgrade: Serbian Biological Society, 2020)

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Krizmanić, Imre
AU  - Borković-Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mitić, Bojan
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4308
AB  - We investigated the activities of superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (GSH-Px), glutathione reductase (GR) and the phase II biotransformation enzyme glutathioneS-transferase (GST) in the whole body of fire salamander larvae (Salamandra salamandra) from twolocalities on Mt. Avala (AVS and ABP) and one locality on Mt. Vršački Breg (VSB), Serbia. We alsodetermined the total glutathione (GSH) and sulfhydryl group (SH) contents, as well as the concentrations ofmanganese (Mn), copper (Cu), zinc (Zn), selenium (Se), arsenic (As), cadmium (Cd), lead (Pb) and uranium(U). The obtained results show that animals from VSB had significantly lower weights and lengths thananimals from AVS and ABP. The activities of all investigated enzymes were significantly higher, while theSH content was significantly lower in animals from VSB compared to those from AVS and ABP. Nocorrelations between trace-element concentrations in water and animal tissue were observed. We concludedthat the obtained results were more likely a consequence of the combination of developmental differencesand the effects of different habitat conditions, environmental and anthropogenic influences than ofconcentrations of trace elements in the water alone.
PB  - Belgrade: Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)
VL  - 72
IS  - 4
DO  - 10.2298/ABS200825043P
ER  - 
@article{
author = "Pavlović, Slađan and Krizmanić, Imre and Borković-Mitić, Slavica and Stojsavljević, Aleksandar and Mitić, Bojan",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4308",
abstract = "We investigated the activities of superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (GSH-Px), glutathione reductase (GR) and the phase II biotransformation enzyme glutathioneS-transferase (GST) in the whole body of fire salamander larvae (Salamandra salamandra) from twolocalities on Mt. Avala (AVS and ABP) and one locality on Mt. Vršački Breg (VSB), Serbia. We alsodetermined the total glutathione (GSH) and sulfhydryl group (SH) contents, as well as the concentrations ofmanganese (Mn), copper (Cu), zinc (Zn), selenium (Se), arsenic (As), cadmium (Cd), lead (Pb) and uranium(U). The obtained results show that animals from VSB had significantly lower weights and lengths thananimals from AVS and ABP. The activities of all investigated enzymes were significantly higher, while theSH content was significantly lower in animals from VSB compared to those from AVS and ABP. Nocorrelations between trace-element concentrations in water and animal tissue were observed. We concludedthat the obtained results were more likely a consequence of the combination of developmental differencesand the effects of different habitat conditions, environmental and anthropogenic influences than ofconcentrations of trace elements in the water alone.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)",
volume = "72",
number = "4",
doi = "10.2298/ABS200825043P"
}
Pavlović, S., Krizmanić, I., Borković-Mitić, S., Stojsavljević, A.,& Mitić, B. (2020). A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia).
Archives of Biological Sciences
Belgrade: Serbian Biological Society., 72(4).
https://doi.org/10.2298/ABS200825043P
Pavlović S, Krizmanić I, Borković-Mitić S, Stojsavljević A, Mitić B. A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia). Archives of Biological Sciences. 2020;72(4)
Pavlović Slađan, Krizmanić Imre, Borković-Mitić Slavica, Stojsavljević Aleksandar, Mitić Bojan, "A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)" Archives of Biological Sciences, 72, no. 4 (2020),
https://doi.org/10.2298/ABS200825043P .

Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Borković-Mitić, Slavica S.; Paunović, Ivan; Kodranov, Igor D.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Kodranov, Igor D.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3285
AB  - Evaluation of trace metals at level of solid tissue can provide better information than blood or urine and, therefore, could highlight the role of metals in the etiology of organ-specific disease. The current study aimed to establish the baseline content of four essential (Mn, Cu, Zn, Se) and four toxic metals (As, Cd, Pb, U) in the healthy thyroid tissues (HTTs) by considering sex, age and smoking habits. A further aim was to examine whether differences in the content of metals exist in regard to the thyroid diseases, such as benign tumor (BT), Hashimoto's thyroiditis (HT), multinodular goiter (MNG) and thyroid cancer (TC). A total number of investigated tissue samples were 423. All metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). It was found that the content of Cu and U was higher in HTTs of women, while the content of Zn was higher in HTTs of men. Increased content of Zn and decreased content of U was found in the group of HTTs above 50 years compared to a younger group (<50 years). Increased content of Cd, Pb and U distinguish smokers from the non-smokers. In comparison with other population groups worldwide, investigated Serbian population had up to 15 times reduced content of Se. Despite the difference in metal's profile according to biological variables, this study also demonstrated, for the first time, that each thyroid disease has its unique metal's profile. The most altered metal's content was found in tissues with HT. Contrarily, the greatest similarity in metal's content with HTTs was found in BT tissues. Based on the increased content, metal's that dominantly discriminated HTTs from the HT, MNG and TC was As, Pb and Cd, respectively. Reported results could highlight the role of toxic and essential trace metals in the not very well clarified etiology of thyroid diseases and, moreover, could provide a molecular basis for pathophysiological changes of metal's hazardous effects on thyroid health at the tissue level.
PB  - Elsevier
T2  - Ecotoxicology and Environmental Safety
T1  - Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases
VL  - 183
DO  - 10.1016/j.ecoenv.2019.109479
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Kodranov, Igor D. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3285",
abstract = "Evaluation of trace metals at level of solid tissue can provide better information than blood or urine and, therefore, could highlight the role of metals in the etiology of organ-specific disease. The current study aimed to establish the baseline content of four essential (Mn, Cu, Zn, Se) and four toxic metals (As, Cd, Pb, U) in the healthy thyroid tissues (HTTs) by considering sex, age and smoking habits. A further aim was to examine whether differences in the content of metals exist in regard to the thyroid diseases, such as benign tumor (BT), Hashimoto's thyroiditis (HT), multinodular goiter (MNG) and thyroid cancer (TC). A total number of investigated tissue samples were 423. All metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). It was found that the content of Cu and U was higher in HTTs of women, while the content of Zn was higher in HTTs of men. Increased content of Zn and decreased content of U was found in the group of HTTs above 50 years compared to a younger group (<50 years). Increased content of Cd, Pb and U distinguish smokers from the non-smokers. In comparison with other population groups worldwide, investigated Serbian population had up to 15 times reduced content of Se. Despite the difference in metal's profile according to biological variables, this study also demonstrated, for the first time, that each thyroid disease has its unique metal's profile. The most altered metal's content was found in tissues with HT. Contrarily, the greatest similarity in metal's content with HTTs was found in BT tissues. Based on the increased content, metal's that dominantly discriminated HTTs from the HT, MNG and TC was As, Pb and Cd, respectively. Reported results could highlight the role of toxic and essential trace metals in the not very well clarified etiology of thyroid diseases and, moreover, could provide a molecular basis for pathophysiological changes of metal's hazardous effects on thyroid health at the tissue level.",
publisher = "Elsevier",
journal = "Ecotoxicology and Environmental Safety",
title = "Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases",
volume = "183",
doi = "10.1016/j.ecoenv.2019.109479"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Kodranov, I. D., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases.
Ecotoxicology and Environmental Safety
Elsevier., 183.
https://doi.org/10.1016/j.ecoenv.2019.109479
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Kodranov ID, Gavrović-Jankulović M, Manojlović DD. Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases. Ecotoxicology and Environmental Safety. 2019;183
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Borković-Mitić Slavica S., Paunović Ivan, Kodranov Igor D., Gavrović-Jankulović Marija, Manojlović Dragan D., "Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases" Ecotoxicology and Environmental Safety, 183 (2019),
https://doi.org/10.1016/j.ecoenv.2019.109479 .
14
9
13

Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Borković-Mitić, Slavica S.; Paunović, Ivan; Kodranov, Igor D.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Kodranov, Igor D.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3286
PB  - Elsevier
T2  - Ecotoxicology and Environmental Safety
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Kodranov, Igor D. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3286",
publisher = "Elsevier",
journal = "Ecotoxicology and Environmental Safety",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Kodranov, I. D., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479.
Ecotoxicology and Environmental Safety
Elsevier..
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Kodranov ID, Gavrović-Jankulović M, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479. Ecotoxicology and Environmental Safety. 2019;
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Borković-Mitić Slavica S., Paunović Ivan, Kodranov Igor D., Gavrović-Jankulović Marija, Manojlović Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479" Ecotoxicology and Environmental Safety (2019)

Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Jagodić, Jovana; Borković-Mitić, Slavica S.; Paunović, Ivan; Živaljević, Vladan; Mitić, Bojan M.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Jagodić, Jovana
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Mitić, Bojan M.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3293
AB  - Background: The etiology of papillary thyroid carcinoma (PTC) is unknown and some literature data support the hypothesis that heavy metals, as endocrine disrupters, could play a major role in the pathogenesis of thyroid cancer. This study aimed to estimate the content of selected toxic and essential trace metals (Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U), as well as the selected ratio's (Cu/Zn and Cd/Se) in the malignant thyroid tissues according to sex, age, smoking habits, familial history of any thyroid disease, pathohistological (PH) types of PTC, tumor size, the existence of a thyroid capsular invasion, intrathyroid tumor dissemination, retrosternal thyroid growth, and TNM progress of PTC. Methods: The study included 66 patients with PTC (women/men ratio = 46/20, mean age: 54 ± 14 years). A comparative analysis was made by collecting the healthy thyroid tissues (HTTs) of the same patients, making the total number of samples 132. All trace metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). Results: Metals that significantly separated papillary thyroid tissues (PTTs) from the HTTs were Cd, U and Se (p < 0.05). The obtained negative correlation between Cd and Se in the PTTs could explain extrusion of essential Se caused by increased content of Cd. Only Cd had an influence on the retrosternal thyroid growth, while the essential metals (Mn, Co, and Zn) had an influence on thyroid capsular invasion. Conclusion: It was found that Cd act as the main endocrine disrupter, which could highlight its role in the etiology of PTC. Considering that the Cd/Se ratio significantly separated two studied groups and had an influence on the retrosternal thyroid growth, its altered content could contribute to the better understanding of the molecular basis for pathophysiological changes in the PTC.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology
VL  - 55
SP  - 190
EP  - 195
DO  - 10.1016/j.jtemb.2019.06.009
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Jagodić, Jovana and Borković-Mitić, Slavica S. and Paunović, Ivan and Živaljević, Vladan and Mitić, Bojan M. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3293",
abstract = "Background: The etiology of papillary thyroid carcinoma (PTC) is unknown and some literature data support the hypothesis that heavy metals, as endocrine disrupters, could play a major role in the pathogenesis of thyroid cancer. This study aimed to estimate the content of selected toxic and essential trace metals (Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U), as well as the selected ratio's (Cu/Zn and Cd/Se) in the malignant thyroid tissues according to sex, age, smoking habits, familial history of any thyroid disease, pathohistological (PH) types of PTC, tumor size, the existence of a thyroid capsular invasion, intrathyroid tumor dissemination, retrosternal thyroid growth, and TNM progress of PTC. Methods: The study included 66 patients with PTC (women/men ratio = 46/20, mean age: 54 ± 14 years). A comparative analysis was made by collecting the healthy thyroid tissues (HTTs) of the same patients, making the total number of samples 132. All trace metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). Results: Metals that significantly separated papillary thyroid tissues (PTTs) from the HTTs were Cd, U and Se (p < 0.05). The obtained negative correlation between Cd and Se in the PTTs could explain extrusion of essential Se caused by increased content of Cd. Only Cd had an influence on the retrosternal thyroid growth, while the essential metals (Mn, Co, and Zn) had an influence on thyroid capsular invasion. Conclusion: It was found that Cd act as the main endocrine disrupter, which could highlight its role in the etiology of PTC. Considering that the Cd/Se ratio significantly separated two studied groups and had an influence on the retrosternal thyroid growth, its altered content could contribute to the better understanding of the molecular basis for pathophysiological changes in the PTC.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology",
volume = "55",
pages = "190-195",
doi = "10.1016/j.jtemb.2019.06.009"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Jagodić, J., Borković-Mitić, S. S., Paunović, I., Živaljević, V., Mitić, B. M., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology.
Journal of Trace Elements in Medicine and Biology
Elsevier., 55, 190-195.
https://doi.org/10.1016/j.jtemb.2019.06.009
Stojsavljević A, Rovčanin B, Krstić ĐD, Jagodić J, Borković-Mitić SS, Paunović I, Živaljević V, Mitić BM, Gavrović-Jankulović M, Manojlović DD. Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology. Journal of Trace Elements in Medicine and Biology. 2019;55:190-195
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Jagodić Jovana, Borković-Mitić Slavica S., Paunović Ivan, Živaljević Vladan, Mitić Bojan M., Gavrović-Jankulović Marija, Manojlović Dragan D., "Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology" Journal of Trace Elements in Medicine and Biology, 55 (2019):190-195,
https://doi.org/10.1016/j.jtemb.2019.06.009 .
13
5
13

Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Jagodić, Jovana; Borković-Mitić, Slavica S.; Paunović, Ivan; Živaljević, Vladan; Mitić, Bojan M.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Jagodić, Jovana
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Mitić, Bojan M.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3294
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Jagodić, Jovana and Borković-Mitić, Slavica S. and Paunović, Ivan and Živaljević, Vladan and Mitić, Bojan M. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3294",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Jagodić, J., Borković-Mitić, S. S., Paunović, I., Živaljević, V., Mitić, B. M., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009.
Journal of Trace Elements in Medicine and Biology
Elsevier..
Stojsavljević A, Rovčanin B, Krstić ĐD, Jagodić J, Borković-Mitić SS, Paunović I, Živaljević V, Mitić BM, Gavrović-Jankulović M, Manojlović DD. Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009. Journal of Trace Elements in Medicine and Biology. 2019;
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Jagodić Jovana, Borković-Mitić Slavica S., Paunović Ivan, Živaljević Vladan, Mitić Bojan M., Gavrović-Jankulović Marija, Manojlović Dragan D., "Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009" Journal of Trace Elements in Medicine and Biology (2019)

Metalomika benignih i malignih oboljenja tiroidne žlezde

Stojsavljević, Aleksandar

(Универзитет у Београду, Хемијски факултет, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
PY  - 2019
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=7018
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:20626/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=51745039
UR  - http://nardus.mpn.gov.rs/123456789/11674
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3903
AB  - Etiologija tiroidnih oboljenja je nedovoljno prouĉena i najnoviji literaturni podaci ukazuju da bi metali mogli da igraju kljuĉnu ulogu u patogenezi velikog broja poremećaja, ukljuĉujući i bolesti tiroidne ţlezde. S tim u vezi, cilj ove studije bio je da se odredi sadrţaj esencijalnih i toksiĉnih metala u zdravim tiroidnim tkivima (ZTT) i napravi komparativna analiza sa sadrţajem metala u tiroidnim tkivima sa dijagnostifikovanim benignim i malignim oboljenjima. Dodatni cilj studije bio je sagledavanje metalomike u zavisnosti od bioloških i kliniĉko-patoloških parametara, kao i pronalaţenje najznaĉajnijeg metala (ili njegovog odnosa sa drugim metalom) koji bi mogao da razdvoji ispitivane grupe i obezbedi informacije o molekulskoj osnovi patofizioloških promena ispitivane bolesti tiroidne ţlezde na tkivnom nivou. Uzorci tkiva za analizu metala sakupljeni su nakon operacije tiroidne ţlezde. U istraţivanju je uĉestvovalo 200 pacijenata, od toga 21 pacijent sa Hašimotovim tiroiditisom (HT), 62 pacijenta sa koloidnom strumom (KS), 36 pacijenata sa benignim tumorima (BT) i 81 pacijent sa malignim tumorima (70 sa papilarnim karcinomom, 8 sa folikularnim i troje sa medularnim karcinomom). Od svakog pacijenta sa dijagnostifikovanim tumorom uzorkovano je i ZTT sa najveće moguće udaljenosti od primarnog tumora, koji je bio jasno demarkiran (n = 117). U svakoj patologiji ispitan je sadrţaj metala u zavisnosti od pola, uzrasta, konzumiranja duvana i veliĉine tiroidnog nodusa. Metalomika papilarnog karcinoma tiroidne ţlezde dodatno je ispitana u zavisnosti od patohistološkog (PH) tipa tumora, prethodne istorije tiroidnog oboljenja u porodici, „TNM“ klasifikacije, prisustva invazije tiroidne kapsule, intratiroidne multicentriĉne diseminacije i retrosternalnog tiroidnog rasta. Uzorci tkiva razoreni su mikrotalasnom digestijom i koncentracija elemenata, mangana (Mn), nikla (Ni), bakra (Cu), cinka (Zn), arsena (As), selena (Se), kadmijuma (Cd), olova (Pb), torijuma (Th) i uranijuma (U) odreĊena je metodom induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Za kvantifikaciju metala ĉije su koncentracije bile veće od 10 μg/L dodatno je primenjena metoda induktivno spregnute plazme sa optiĉkom emisionom spektrometrijom (ICP-OES). Za obradu dobijenih podataka primenjene su uni- i multivarijantne statistiĉke metode. PronaĊeno je da je sadrţaj selena u ZTT bio znaĉajno smanjen (i do 15 puta) u poreĊenju sa drugim populacionim grupama širom sveta, na osnovu ĉega bi mogla da se istakne deficijencija selena u ispitivanoj grupi srpske populacije. UtvrĊeno je da patološka tiroidna tkiva imaju znaĉajno izmenjen sadrţaj velikog broja metala u poreĊenju sa ZTT...
AB  - The etiology of thyroid diseases is not very well clarified and the latest literature data indicated that metals could play a key role in the pathogenesis of a great number of disorders, including the thyroid gland diseases. In this regard, the aim of this study was to determine the content of toxic and essential metals in the healthy thyroid tissues (HTTs), as well as to compare the content of metals in tissues with diagnosed benign and malignant thyroid gland diseases. The further aim of this study was to investigate metallomics according to the biological-, clinical- and pathological-parameters, as well as to find the most significant metal (or its ratio to another metal) that could separate examined groups, as well as to provide additional information on the molecular basis of pathophysiological changes of the examined thyroid disease at the tissue’s level. Tissue samples for metal analysis were collected after thyroid surgery. The study included 200 patients, of which 21 patients with Hashimoto’s thyroiditis (HT), 62 patients with colloid goiter (CG), 36 patients with benign tumors (BTs) and 81 patients with malignant tumors (70 with papillary carcinoma, 8 with follicular and three with medullary thyroid carcinoma). HTT was sampled from each patient with diagnosed tumor from the greatest possible distance from the primary tumor, which was well demarked (n = 117). In each pathology, the content of metals was investigated according to sex, age, smoking habits and goiter size. Metallomics of the papillary thyroid carcinoma (PTC) was further examined based on the pathohistological (PH) type of tumor, previous history of any thyroid disease in the family, TNM classification, capsular invasion, intrathyroid dissemination, and the retrosternal thyroid growth. Tissue samples were decomposed by microwave digestion and the concentration of elements, manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), lead (Pb), thorium (Th) and uranium (U) was determined by inductively coupled plasma-mass spectrometry (ICP-MS). Inductively coupled plasma-optical emission spectrometry (ICP-OES) was additionally used to quantify metals with concentrations higher than 10 μg/L. Uni- and multivariate statistical methods were applied for data analysis. It was found that the content of selenium in the HTTs was significantly reduced (up to 15 times) compared to other population groups worldwide, which could highlight the deficiency of Se in the investigated group of Serbian population. It was estimated that pathological thyroid tissues had significantly altered metal’s content when compared to the HTTs. The most altered metal’s content was found in tissues of patients with the HT...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Metalomika benignih i malignih oboljenja tiroidne žlezde
ER  - 
@phdthesis{
author = "Stojsavljević, Aleksandar",
year = "2019",
url = "http://eteze.bg.ac.rs/application/showtheses?thesesId=7018, https://fedorabg.bg.ac.rs/fedora/get/o:20626/bdef:Content/download, http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=51745039, http://nardus.mpn.gov.rs/123456789/11674, http://cherry.chem.bg.ac.rs/handle/123456789/3903",
abstract = "Etiologija tiroidnih oboljenja je nedovoljno prouĉena i najnoviji literaturni podaci ukazuju da bi metali mogli da igraju kljuĉnu ulogu u patogenezi velikog broja poremećaja, ukljuĉujući i bolesti tiroidne ţlezde. S tim u vezi, cilj ove studije bio je da se odredi sadrţaj esencijalnih i toksiĉnih metala u zdravim tiroidnim tkivima (ZTT) i napravi komparativna analiza sa sadrţajem metala u tiroidnim tkivima sa dijagnostifikovanim benignim i malignim oboljenjima. Dodatni cilj studije bio je sagledavanje metalomike u zavisnosti od bioloških i kliniĉko-patoloških parametara, kao i pronalaţenje najznaĉajnijeg metala (ili njegovog odnosa sa drugim metalom) koji bi mogao da razdvoji ispitivane grupe i obezbedi informacije o molekulskoj osnovi patofizioloških promena ispitivane bolesti tiroidne ţlezde na tkivnom nivou. Uzorci tkiva za analizu metala sakupljeni su nakon operacije tiroidne ţlezde. U istraţivanju je uĉestvovalo 200 pacijenata, od toga 21 pacijent sa Hašimotovim tiroiditisom (HT), 62 pacijenta sa koloidnom strumom (KS), 36 pacijenata sa benignim tumorima (BT) i 81 pacijent sa malignim tumorima (70 sa papilarnim karcinomom, 8 sa folikularnim i troje sa medularnim karcinomom). Od svakog pacijenta sa dijagnostifikovanim tumorom uzorkovano je i ZTT sa najveće moguće udaljenosti od primarnog tumora, koji je bio jasno demarkiran (n = 117). U svakoj patologiji ispitan je sadrţaj metala u zavisnosti od pola, uzrasta, konzumiranja duvana i veliĉine tiroidnog nodusa. Metalomika papilarnog karcinoma tiroidne ţlezde dodatno je ispitana u zavisnosti od patohistološkog (PH) tipa tumora, prethodne istorije tiroidnog oboljenja u porodici, „TNM“ klasifikacije, prisustva invazije tiroidne kapsule, intratiroidne multicentriĉne diseminacije i retrosternalnog tiroidnog rasta. Uzorci tkiva razoreni su mikrotalasnom digestijom i koncentracija elemenata, mangana (Mn), nikla (Ni), bakra (Cu), cinka (Zn), arsena (As), selena (Se), kadmijuma (Cd), olova (Pb), torijuma (Th) i uranijuma (U) odreĊena je metodom induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Za kvantifikaciju metala ĉije su koncentracije bile veće od 10 μg/L dodatno je primenjena metoda induktivno spregnute plazme sa optiĉkom emisionom spektrometrijom (ICP-OES). Za obradu dobijenih podataka primenjene su uni- i multivarijantne statistiĉke metode. PronaĊeno je da je sadrţaj selena u ZTT bio znaĉajno smanjen (i do 15 puta) u poreĊenju sa drugim populacionim grupama širom sveta, na osnovu ĉega bi mogla da se istakne deficijencija selena u ispitivanoj grupi srpske populacije. UtvrĊeno je da patološka tiroidna tkiva imaju znaĉajno izmenjen sadrţaj velikog broja metala u poreĊenju sa ZTT..., The etiology of thyroid diseases is not very well clarified and the latest literature data indicated that metals could play a key role in the pathogenesis of a great number of disorders, including the thyroid gland diseases. In this regard, the aim of this study was to determine the content of toxic and essential metals in the healthy thyroid tissues (HTTs), as well as to compare the content of metals in tissues with diagnosed benign and malignant thyroid gland diseases. The further aim of this study was to investigate metallomics according to the biological-, clinical- and pathological-parameters, as well as to find the most significant metal (or its ratio to another metal) that could separate examined groups, as well as to provide additional information on the molecular basis of pathophysiological changes of the examined thyroid disease at the tissue’s level. Tissue samples for metal analysis were collected after thyroid surgery. The study included 200 patients, of which 21 patients with Hashimoto’s thyroiditis (HT), 62 patients with colloid goiter (CG), 36 patients with benign tumors (BTs) and 81 patients with malignant tumors (70 with papillary carcinoma, 8 with follicular and three with medullary thyroid carcinoma). HTT was sampled from each patient with diagnosed tumor from the greatest possible distance from the primary tumor, which was well demarked (n = 117). In each pathology, the content of metals was investigated according to sex, age, smoking habits and goiter size. Metallomics of the papillary thyroid carcinoma (PTC) was further examined based on the pathohistological (PH) type of tumor, previous history of any thyroid disease in the family, TNM classification, capsular invasion, intrathyroid dissemination, and the retrosternal thyroid growth. Tissue samples were decomposed by microwave digestion and the concentration of elements, manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), lead (Pb), thorium (Th) and uranium (U) was determined by inductively coupled plasma-mass spectrometry (ICP-MS). Inductively coupled plasma-optical emission spectrometry (ICP-OES) was additionally used to quantify metals with concentrations higher than 10 μg/L. Uni- and multivariate statistical methods were applied for data analysis. It was found that the content of selenium in the HTTs was significantly reduced (up to 15 times) compared to other population groups worldwide, which could highlight the deficiency of Se in the investigated group of Serbian population. It was estimated that pathological thyroid tissues had significantly altered metal’s content when compared to the HTTs. The most altered metal’s content was found in tissues of patients with the HT...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Metalomika benignih i malignih oboljenja tiroidne žlezde"
}
Stojsavljević, A. (2019). Metalomika benignih i malignih oboljenja tiroidne žlezde.
Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
Stojsavljević A. Metalomika benignih i malignih oboljenja tiroidne žlezde. Универзитет у Београду. 2019;
Stojsavljević Aleksandar, "Metalomika benignih i malignih oboljenja tiroidne žlezde" Универзитет у Београду (2019)

The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples

Stojsavljević, Aleksandar; Škrivanj, Sandra B.; Trifković, Jelena; Đoković, Nenad; Trifunović, Srećko R.; Borković-Mitić, Slavica S.; Manojlović, Dragan D.

(Springer, 2019)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Škrivanj, Sandra B.
AU  - Trifković, Jelena
AU  - Đoković, Nenad
AU  - Trifunović, Srećko R.
AU  - Borković-Mitić, Slavica S.
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3687
AB  - Pollution caused by heavy metals affects all forms of life. The aim of the study was to determine the content of toxic (Sr, Ni, Pb, V, Cd, U, Rb, As) and essential (Na, K, Ca, Mg, Zn, Cu, Se, Mn, Cr, Mo, Co) metals in the bone and whole blood samples, in regard to clinical means of long- and short-term exposure, respectively. For this purpose, the cortical and trabecular parts of femoral neck, as well as the blood samples, were collected to quantify bone-important metals by inductively coupled plasma (ICP)-based techniques. According to principal component analysis (PCA), the most influential metal discriminating blood samples was Cu, while all other quantified elements were present in higher amounts in the bones. Additionally, trabecular bones (TBs) could be characterized by higher content of Mo, Cr, V, Mn, Co, As, and Ni compared to cortical bones (CBs). Linear discrimination analysis (LDA) was successfully applied to distinguish trabecular bone from the cortical bone. Significant correlation between essential Ca and toxic Sr with other elements was found and discussed. This study provides novel data on the effects of metal pollutants on bone health hazards. The results obtained for investigating metals may serve as a baseline for further clinical investigations in the orthopedic fields.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples
VL  - 26
IS  - 16
SP  - 16577
EP  - 16587
DO  - 10.1007/s11356-019-04796-w
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Škrivanj, Sandra B. and Trifković, Jelena and Đoković, Nenad and Trifunović, Srećko R. and Borković-Mitić, Slavica S. and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3687",
abstract = "Pollution caused by heavy metals affects all forms of life. The aim of the study was to determine the content of toxic (Sr, Ni, Pb, V, Cd, U, Rb, As) and essential (Na, K, Ca, Mg, Zn, Cu, Se, Mn, Cr, Mo, Co) metals in the bone and whole blood samples, in regard to clinical means of long- and short-term exposure, respectively. For this purpose, the cortical and trabecular parts of femoral neck, as well as the blood samples, were collected to quantify bone-important metals by inductively coupled plasma (ICP)-based techniques. According to principal component analysis (PCA), the most influential metal discriminating blood samples was Cu, while all other quantified elements were present in higher amounts in the bones. Additionally, trabecular bones (TBs) could be characterized by higher content of Mo, Cr, V, Mn, Co, As, and Ni compared to cortical bones (CBs). Linear discrimination analysis (LDA) was successfully applied to distinguish trabecular bone from the cortical bone. Significant correlation between essential Ca and toxic Sr with other elements was found and discussed. This study provides novel data on the effects of metal pollutants on bone health hazards. The results obtained for investigating metals may serve as a baseline for further clinical investigations in the orthopedic fields.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples",
volume = "26",
number = "16",
pages = "16577-16587",
doi = "10.1007/s11356-019-04796-w"
}
Stojsavljević, A., Škrivanj, S. B., Trifković, J., Đoković, N., Trifunović, S. R., Borković-Mitić, S. S.,& Manojlović, D. D. (2019). The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples.
Environmental Science and Pollution Research
Springer., 26(16), 16577-16587.
https://doi.org/10.1007/s11356-019-04796-w
Stojsavljević A, Škrivanj SB, Trifković J, Đoković N, Trifunović SR, Borković-Mitić SS, Manojlović DD. The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples. Environmental Science and Pollution Research. 2019;26(16):16577-16587
Stojsavljević Aleksandar, Škrivanj Sandra B., Trifković Jelena, Đoković Nenad, Trifunović Srećko R., Borković-Mitić Slavica S., Manojlović Dragan D., "The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples" Environmental Science and Pollution Research, 26, no. 16 (2019):16577-16587,
https://doi.org/10.1007/s11356-019-04796-w .
2
1
2

Supplementary data for the article: Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w

Stojsavljević, Aleksandar; Škrivanj, Sandra B.; Trifković, Jelena; Đoković, Nenad; Trifunović, Srećko R.; Borković-Mitić, Slavica S.; Manojlović, Dragan D.

(Springer, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Škrivanj, Sandra B.
AU  - Trifković, Jelena
AU  - Đoković, Nenad
AU  - Trifunović, Srećko R.
AU  - Borković-Mitić, Slavica S.
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3688
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w
DO  - 10.1007/s11356-019-04796-w
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Škrivanj, Sandra B. and Trifković, Jelena and Đoković, Nenad and Trifunović, Srećko R. and Borković-Mitić, Slavica S. and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3688",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w",
doi = "10.1007/s11356-019-04796-w"
}
Stojsavljević, A., Škrivanj, S. B., Trifković, J., Đoković, N., Trifunović, S. R., Borković-Mitić, S. S.,& Manojlović, D. D. (2019). Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w.
Environmental Science and Pollution Research
Springer..
https://doi.org/10.1007/s11356-019-04796-w
Stojsavljević A, Škrivanj SB, Trifković J, Đoković N, Trifunović SR, Borković-Mitić SS, Manojlović DD. Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w. Environmental Science and Pollution Research. 2019;
Stojsavljević Aleksandar, Škrivanj Sandra B., Trifković Jelena, Đoković Nenad, Trifunović Srećko R., Borković-Mitić Slavica S., Manojlović Dragan D., "Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w" Environmental Science and Pollution Research (2019),
https://doi.org/10.1007/s11356-019-04796-w .
2
1
2

Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism

Stojsavljević, Aleksandar; Trifković, Jelena; Rašić-Milutinović, Zorica; Jovanović, Dragana; Bogdanović, Gradimir; Mutić, Jelena; Manojlović, Dragan D.

(Elsevier Gmbh, Urban & Fischer Verlag, Jena, 2018)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Trifković, Jelena
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Bogdanović, Gradimir
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3074
AB  - Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism
VL  - 48
SP  - 134
EP  - 140
DO  - 10.1016/j.jtemb.2018.03.020
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Trifković, Jelena and Rašić-Milutinović, Zorica and Jovanović, Dragana and Bogdanović, Gradimir and Mutić, Jelena and Manojlović, Dragan D.",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3074",
abstract = "Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism",
volume = "48",
pages = "134-140",
doi = "10.1016/j.jtemb.2018.03.020"
}
Stojsavljević, A., Trifković, J., Rašić-Milutinović, Z., Jovanović, D., Bogdanović, G., Mutić, J.,& Manojlović, D. D. (2018). Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism.
Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 48, 134-140.
https://doi.org/10.1016/j.jtemb.2018.03.020
Stojsavljević A, Trifković J, Rašić-Milutinović Z, Jovanović D, Bogdanović G, Mutić J, Manojlović DD. Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. Journal of Trace Elements in Medicine and Biology. 2018;48:134-140
Stojsavljević Aleksandar, Trifković Jelena, Rašić-Milutinović Zorica, Jovanović Dragana, Bogdanović Gradimir, Mutić Jelena, Manojlović Dragan D., "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism" Journal of Trace Elements in Medicine and Biology, 48 (2018):134-140,
https://doi.org/10.1016/j.jtemb.2018.03.020 .
13
9
13

Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020

Stojsavljević, Aleksandar; Trifković, Jelena; Rašić-Milutinović, Zorica; Jovanović, Dragana; Bogdanović, Gradimir; Mutić, Jelena; Manojlović, Dragan D.

(Elsevier Gmbh, Urban & Fischer Verlag, Jena, 2018)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Trifković, Jelena
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Bogdanović, Gradimir
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3075
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Trifković, Jelena and Rašić-Milutinović, Zorica and Jovanović, Dragana and Bogdanović, Gradimir and Mutić, Jelena and Manojlović, Dragan D.",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3075",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020"
}
Stojsavljević, A., Trifković, J., Rašić-Milutinović, Z., Jovanović, D., Bogdanović, G., Mutić, J.,& Manojlović, D. D. (2018). Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020.
Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Urban & Fischer Verlag, Jena..
Stojsavljević A, Trifković J, Rašić-Milutinović Z, Jovanović D, Bogdanović G, Mutić J, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020. Journal of Trace Elements in Medicine and Biology. 2018;
Stojsavljević Aleksandar, Trifković Jelena, Rašić-Milutinović Zorica, Jovanović Dragana, Bogdanović Gradimir, Mutić Jelena, Manojlović Dragan D., "Supplementary data for the article: Stojsavljević, A.; Trifković, J.; Rasić-Milutinović, Z.; Jovanović, D.; Bogdanović, G.; Mutić, J.; Manojlović, D. Determination of Toxic and Essential Trace Elements in Serum of Healthy and Hypothyroid Respondents by ICP-MS: A Chemometric Approach for Discrimination of Hypothyroidism. Journal of Trace Elements in Medicine and Biology 2018, 48, 134–140. https://doi.org/10.1016/j.jtemb.2018.03.020" Journal of Trace Elements in Medicine and Biology (2018)

Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism

Stojsavljević, Aleksandar; Trifković, Jelena; Rašić-Milutinović, Zorica; Jovanović, Dragana; Bogdanović, Gradimir; Mutić, Jelena; Manojlović, Dragan D.

(Elsevier Gmbh, Urban & Fischer Verlag, Jena, 2018)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Trifković, Jelena
AU  - Rašić-Milutinović, Zorica
AU  - Jovanović, Dragana
AU  - Bogdanović, Gradimir
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2181
AB  - Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism
VL  - 48
SP  - 134
EP  - 140
DO  - 10.1016/j.jtemb.2018.03.020
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Trifković, Jelena and Rašić-Milutinović, Zorica and Jovanović, Dragana and Bogdanović, Gradimir and Mutić, Jelena and Manojlović, Dragan D.",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2181",
abstract = "Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for Cr-52, Zn-66, As-75, Cd-112 in collision mode, and Mn-55, (CO)-C-59, Ni-60, Cu-65, Se-78 in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p  lt  0.01) was observed for several elements. Results indicated clear differences in element profile between Hy and control group and it could be used as a unique profile of hypothyroid state.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism",
volume = "48",
pages = "134-140",
doi = "10.1016/j.jtemb.2018.03.020"
}
Stojsavljević, A., Trifković, J., Rašić-Milutinović, Z., Jovanović, D., Bogdanović, G., Mutić, J.,& Manojlović, D. D. (2018). Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism.
Journal of Trace Elements in Medicine and Biology
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 48, 134-140.
https://doi.org/10.1016/j.jtemb.2018.03.020
Stojsavljević A, Trifković J, Rašić-Milutinović Z, Jovanović D, Bogdanović G, Mutić J, Manojlović DD. Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. Journal of Trace Elements in Medicine and Biology. 2018;48:134-140
Stojsavljević Aleksandar, Trifković Jelena, Rašić-Milutinović Zorica, Jovanović Dragana, Bogdanović Gradimir, Mutić Jelena, Manojlović Dragan D., "Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism" Journal of Trace Elements in Medicine and Biology, 48 (2018):134-140,
https://doi.org/10.1016/j.jtemb.2018.03.020 .
13
9
13