Borković-Mitić, Slavica S.

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orcid::0000-0003-4895-9985
  • Borković-Mitić, Slavica S. (16)
  • Borković-Mitić, Slavica (4)
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Author's Bibliography

Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.

Đurašević, Siniša; Stojković, Maja; Sopta, Jelena; Pavlović, Slađan; Borković-Mitić, Slavica; Ivanović, Anđelija; Jasnić, Nebojša; Tosti, Tomislav; Đurović, Saša; Đorđević, Jelena; Todorović, Zoran

(Springer Nature, 2021)

TY  - BOOK
AU  - Đurašević, Siniša
AU  - Stojković, Maja
AU  - Sopta, Jelena
AU  - Pavlović, Slađan
AU  - Borković-Mitić, Slavica
AU  - Ivanović, Anđelija
AU  - Jasnić, Nebojša
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4459
PB  - Springer Nature
T2  - Scientific Reports
T1  - Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.
ER  - 
@book{
author = "Đurašević, Siniša and Stojković, Maja and Sopta, Jelena and Pavlović, Slađan and Borković-Mitić, Slavica and Ivanović, Anđelija and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Đorđević, Jelena and Todorović, Zoran",
year = "2021",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4459",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y."
}
Đurašević, S., Stojković, M., Sopta, J., Pavlović, S., Borković-Mitić, S., Ivanović, A., Jasnić, N., Tosti, T., Đurović, S., Đorđević, J.,& Todorović, Z. (2021). Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y..
Scientific Reports
Springer Nature..
Đurašević S, Stojković M, Sopta J, Pavlović S, Borković-Mitić S, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović Z. Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.. Scientific Reports. 2021;
Đurašević Siniša, Stojković Maja, Sopta Jelena, Pavlović Slađan, Borković-Mitić Slavica, Ivanović Anđelija, Jasnić Nebojša, Tosti Tomislav, Đurović Saša, Đorđević Jelena, Todorović Zoran, "Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y." Scientific Reports (2021)

The effects of meldonium on the acute ischemia/reperfusion liver injury in rats

Đurašević, Siniša; Stojković, Maja; Sopta, Jelena; Pavlović, Slađan; Borković-Mitić, Slavica; Ivanović, Anđelija; Jasnić, Nebojša; Tosti, Tomislav; Đurović, Saša; Đorđević, Jelena; Todorović, Zoran

(Springer Nature, 2021)

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Stojković, Maja
AU  - Sopta, Jelena
AU  - Pavlović, Slađan
AU  - Borković-Mitić, Slavica
AU  - Ivanović, Anđelija
AU  - Jasnić, Nebojša
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2021
UR  - https://www.nature.com/articles/s41598-020-80011-y
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4458
AB  - Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.
PB  - Springer Nature
T2  - Scientific Reports
T2  - Scientific ReportsSci Rep
T1  - The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
VL  - 11
IS  - 1
SP  - 1305
DO  - 10.1038/s41598-020-80011-y
ER  - 
@article{
author = "Đurašević, Siniša and Stojković, Maja and Sopta, Jelena and Pavlović, Slađan and Borković-Mitić, Slavica and Ivanović, Anđelija and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Đorđević, Jelena and Todorović, Zoran",
year = "2021",
url = "https://www.nature.com/articles/s41598-020-80011-y, http://cherry.chem.bg.ac.rs/handle/123456789/4458",
abstract = "Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.",
publisher = "Springer Nature",
journal = "Scientific Reports, Scientific ReportsSci Rep",
title = "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats",
volume = "11",
number = "1",
pages = "1305",
doi = "10.1038/s41598-020-80011-y"
}
Đurašević, S., Stojković, M., Sopta, J., Pavlović, S., Borković-Mitić, S., Ivanović, A., Jasnić, N., Tosti, T., Đurović, S., Đorđević, J.,& Todorović, Z. (2021). The effects of meldonium on the acute ischemia/reperfusion liver injury in rats.
Scientific ReportsSci Rep
Springer Nature., 11(1), 1305.
https://doi.org/10.1038/s41598-020-80011-y
Đurašević S, Stojković M, Sopta J, Pavlović S, Borković-Mitić S, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović Z. The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. Scientific ReportsSci Rep. 2021;11(1):1305
Đurašević Siniša, Stojković Maja, Sopta Jelena, Pavlović Slađan, Borković-Mitić Slavica, Ivanović Anđelija, Jasnić Nebojša, Tosti Tomislav, Đurović Saša, Đorđević Jelena, Todorović Zoran, "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats" Scientific ReportsSci Rep, 11, no. 1 (2021):1305,
https://doi.org/10.1038/s41598-020-80011-y .
1
2

Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus

Vujotić, Ljiljana; Matić, Siniša; Borković-Mitić, Slavica; Stojsavljević, Aleksandar; Mutić, Jelena; Baščarević, Vladimir; Joković, Miloš; Pavlović, Slađan Z.

(Termedia Publishing House, 2020)

TY  - JOUR
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Borković-Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mutić, Jelena
AU  - Baščarević, Vladimir
AU  - Joković, Miloš
AU  - Pavlović, Slađan Z.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3982
AB  - Introduction: Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus. Material and methods: Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe. Results: The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor. Conclusions: There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.
PB  - Termedia Publishing House
T2  - Archives of Medical Science
T1  - Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus
VL  - 16
IS  - 4
SP  - 811
EP  - 819
DO  - 10.5114/aoms.2019.87409
ER  - 
@article{
author = "Vujotić, Ljiljana and Matić, Siniša and Borković-Mitić, Slavica and Stojsavljević, Aleksandar and Mutić, Jelena and Baščarević, Vladimir and Joković, Miloš and Pavlović, Slađan Z.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3982",
abstract = "Introduction: Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus. Material and methods: Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe. Results: The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor. Conclusions: There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.",
publisher = "Termedia Publishing House",
journal = "Archives of Medical Science",
title = "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus",
volume = "16",
number = "4",
pages = "811-819",
doi = "10.5114/aoms.2019.87409"
}
Vujotić, L., Matić, S., Borković-Mitić, S., Stojsavljević, A., Mutić, J., Baščarević, V., Joković, M.,& Pavlović, S. Z. (2020). Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus.
Archives of Medical Science
Termedia Publishing House., 16(4), 811-819.
https://doi.org/10.5114/aoms.2019.87409
Vujotić L, Matić S, Borković-Mitić S, Stojsavljević A, Mutić J, Baščarević V, Joković M, Pavlović SZ. Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus. Archives of Medical Science. 2020;16(4):811-819
Vujotić Ljiljana, Matić Siniša, Borković-Mitić Slavica, Stojsavljević Aleksandar, Mutić Jelena, Baščarević Vladimir, Joković Miloš, Pavlović Slađan Z., "Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus" Archives of Medical Science, 16, no. 4 (2020):811-819,
https://doi.org/10.5114/aoms.2019.87409 .
2
1
1

Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Borković-Mitić, Slavica S.; Paunović, Ivan; Diklić, Aleksandar; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(2020)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Diklić, Aleksandar
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3955
AB  - The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlight its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].
T2  - Exposure and Health
T1  - Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease
VL  - 12
IS  - 2
SP  - 255
EP  - 264
DO  - 10.1007/s12403-019-00309-9
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Diklić, Aleksandar and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3955",
abstract = "The background level of lead (Pb) in drinking water in Serbia represents a significant health issue. The aim of study was to examine the content of significant toxic and essential trace metals (Mn, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U) in the thyroid tissues with diagnosed colloid goiter (CG). Different variables were investigated (sex, age, smoking habits, goiter size, and previous history of any thyroid disease). The study was designed to compare the goiter tissues (GTs) to sex- and age-matched healthy- and malignant-thyroid tissues (HTTs and MTTs, respectively). All trace metals were quantified by inductively coupled plasma mass spectrometry (ICP-MS). The reduced content of essential elements (Mn and Se) and increased content of toxic metals (Pb, Th, and U) were found in GTs compared with HTTs. The increased content of the same toxic metals separated GTs from MTTs, as well as reduced content of Mn and Cd. Our results indicated that Pb acts as the main goitrogen, which could highlight its role in the unknown etiology of CG disease. Pb/Se ratio could be considered as a relevant parameter for the tissue separation of GTs from HTTs and/or MTTs. This research also provides novel data on the effects of metal pollutants on thyroid health hazards. Graphical Abstract: [Figure not available: see fulltext.].",
journal = "Exposure and Health",
title = "Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease",
volume = "12",
number = "2",
pages = "255-264",
doi = "10.1007/s12403-019-00309-9"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Diklić, A., Gavrović-Jankulović, M.,& Manojlović, D. D. (2020). Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease.
Exposure and Health, 12(2), 255-264.
https://doi.org/10.1007/s12403-019-00309-9
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Diklić A, Gavrović-Jankulović M, Manojlović DD. Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease. Exposure and Health. 2020;12(2):255-264
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Borković-Mitić Slavica S., Paunović Ivan, Diklić Aleksandar, Gavrović-Jankulović Marija, Manojlović Dragan D., "Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease" Exposure and Health, 12, no. 2 (2020):255-264,
https://doi.org/10.1007/s12403-019-00309-9 .
5
3
5

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević, Aleksandar; Vujotić, Ljiljana; Rovčanin, Branislav; Borković-Mitić, Slavica S.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Nature Research, 2020)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Vujotić, Ljiljana
AU  - Rovčanin, Branislav
AU  - Borković-Mitić, Slavica S.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3885
AB  - The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.
PB  - Nature Research
T2  - Scientific Reports
T1  - Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors
VL  - 10
IS  - 1
DO  - 10.1038/s41598-020-60774-0
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Vujotić, Ljiljana and Rovčanin, Branislav and Borković-Mitić, Slavica S. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3885",
abstract = "The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors",
volume = "10",
number = "1",
doi = "10.1038/s41598-020-60774-0"
}
Stojsavljević, A., Vujotić, L., Rovčanin, B., Borković-Mitić, S. S., Gavrović-Jankulović, M.,& Manojlović, D. D. (2020). Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors.
Scientific Reports
Nature Research., 10(1).
https://doi.org/10.1038/s41598-020-60774-0
Stojsavljević A, Vujotić L, Rovčanin B, Borković-Mitić SS, Gavrović-Jankulović M, Manojlović DD. Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors. Scientific Reports. 2020;10(1)
Stojsavljević Aleksandar, Vujotić Ljiljana, Rovčanin Branislav, Borković-Mitić Slavica S., Gavrović-Jankulović Marija, Manojlović Dragan D., "Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors" Scientific Reports, 10, no. 1 (2020),
https://doi.org/10.1038/s41598-020-60774-0 .
6
2
5

A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)

Pavlović, Slađan; Krizmanić, Imre; Borković-Mitić, Slavica; Stojsavljević, Aleksandar; Mitić, Bojan

(Belgrade: Serbian Biological Society, 2020)

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Krizmanić, Imre
AU  - Borković-Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Mitić, Bojan
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4308
AB  - We investigated the activities of superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (GSH-Px), glutathione reductase (GR) and the phase II biotransformation enzyme glutathioneS-transferase (GST) in the whole body of fire salamander larvae (Salamandra salamandra) from twolocalities on Mt. Avala (AVS and ABP) and one locality on Mt. Vršački Breg (VSB), Serbia. We alsodetermined the total glutathione (GSH) and sulfhydryl group (SH) contents, as well as the concentrations ofmanganese (Mn), copper (Cu), zinc (Zn), selenium (Se), arsenic (As), cadmium (Cd), lead (Pb) and uranium(U). The obtained results show that animals from VSB had significantly lower weights and lengths thananimals from AVS and ABP. The activities of all investigated enzymes were significantly higher, while theSH content was significantly lower in animals from VSB compared to those from AVS and ABP. Nocorrelations between trace-element concentrations in water and animal tissue were observed. We concludedthat the obtained results were more likely a consequence of the combination of developmental differencesand the effects of different habitat conditions, environmental and anthropogenic influences than ofconcentrations of trace elements in the water alone.
PB  - Belgrade: Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)
VL  - 72
IS  - 4
DO  - 10.2298/ABS200825043P
ER  - 
@article{
author = "Pavlović, Slađan and Krizmanić, Imre and Borković-Mitić, Slavica and Stojsavljević, Aleksandar and Mitić, Bojan",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/4308",
abstract = "We investigated the activities of superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (GSH-Px), glutathione reductase (GR) and the phase II biotransformation enzyme glutathioneS-transferase (GST) in the whole body of fire salamander larvae (Salamandra salamandra) from twolocalities on Mt. Avala (AVS and ABP) and one locality on Mt. Vršački Breg (VSB), Serbia. We alsodetermined the total glutathione (GSH) and sulfhydryl group (SH) contents, as well as the concentrations ofmanganese (Mn), copper (Cu), zinc (Zn), selenium (Se), arsenic (As), cadmium (Cd), lead (Pb) and uranium(U). The obtained results show that animals from VSB had significantly lower weights and lengths thananimals from AVS and ABP. The activities of all investigated enzymes were significantly higher, while theSH content was significantly lower in animals from VSB compared to those from AVS and ABP. Nocorrelations between trace-element concentrations in water and animal tissue were observed. We concludedthat the obtained results were more likely a consequence of the combination of developmental differencesand the effects of different habitat conditions, environmental and anthropogenic influences than ofconcentrations of trace elements in the water alone.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)",
volume = "72",
number = "4",
doi = "10.2298/ABS200825043P"
}
Pavlović, S., Krizmanić, I., Borković-Mitić, S., Stojsavljević, A.,& Mitić, B. (2020). A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia).
Archives of Biological Sciences
Belgrade: Serbian Biological Society., 72(4).
https://doi.org/10.2298/ABS200825043P
Pavlović S, Krizmanić I, Borković-Mitić S, Stojsavljević A, Mitić B. A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia). Archives of Biological Sciences. 2020;72(4)
Pavlović Slađan, Krizmanić Imre, Borković-Mitić Slavica, Stojsavljević Aleksandar, Mitić Bojan, "A first record of the antioxidant defense and selected trace elements in Salamandra salamandra larvae on Mt. Avala and Mt. Vršački Breg (Serbia)" Archives of Biological Sciences, 72, no. 4 (2020),
https://doi.org/10.2298/ABS200825043P .

Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Borković-Mitić, Slavica S.; Paunović, Ivan; Kodranov, Igor D.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Kodranov, Igor D.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3285
AB  - Evaluation of trace metals at level of solid tissue can provide better information than blood or urine and, therefore, could highlight the role of metals in the etiology of organ-specific disease. The current study aimed to establish the baseline content of four essential (Mn, Cu, Zn, Se) and four toxic metals (As, Cd, Pb, U) in the healthy thyroid tissues (HTTs) by considering sex, age and smoking habits. A further aim was to examine whether differences in the content of metals exist in regard to the thyroid diseases, such as benign tumor (BT), Hashimoto's thyroiditis (HT), multinodular goiter (MNG) and thyroid cancer (TC). A total number of investigated tissue samples were 423. All metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). It was found that the content of Cu and U was higher in HTTs of women, while the content of Zn was higher in HTTs of men. Increased content of Zn and decreased content of U was found in the group of HTTs above 50 years compared to a younger group (<50 years). Increased content of Cd, Pb and U distinguish smokers from the non-smokers. In comparison with other population groups worldwide, investigated Serbian population had up to 15 times reduced content of Se. Despite the difference in metal's profile according to biological variables, this study also demonstrated, for the first time, that each thyroid disease has its unique metal's profile. The most altered metal's content was found in tissues with HT. Contrarily, the greatest similarity in metal's content with HTTs was found in BT tissues. Based on the increased content, metal's that dominantly discriminated HTTs from the HT, MNG and TC was As, Pb and Cd, respectively. Reported results could highlight the role of toxic and essential trace metals in the not very well clarified etiology of thyroid diseases and, moreover, could provide a molecular basis for pathophysiological changes of metal's hazardous effects on thyroid health at the tissue level.
PB  - Elsevier
T2  - Ecotoxicology and Environmental Safety
T1  - Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases
VL  - 183
DO  - 10.1016/j.ecoenv.2019.109479
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Kodranov, Igor D. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3285",
abstract = "Evaluation of trace metals at level of solid tissue can provide better information than blood or urine and, therefore, could highlight the role of metals in the etiology of organ-specific disease. The current study aimed to establish the baseline content of four essential (Mn, Cu, Zn, Se) and four toxic metals (As, Cd, Pb, U) in the healthy thyroid tissues (HTTs) by considering sex, age and smoking habits. A further aim was to examine whether differences in the content of metals exist in regard to the thyroid diseases, such as benign tumor (BT), Hashimoto's thyroiditis (HT), multinodular goiter (MNG) and thyroid cancer (TC). A total number of investigated tissue samples were 423. All metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). It was found that the content of Cu and U was higher in HTTs of women, while the content of Zn was higher in HTTs of men. Increased content of Zn and decreased content of U was found in the group of HTTs above 50 years compared to a younger group (<50 years). Increased content of Cd, Pb and U distinguish smokers from the non-smokers. In comparison with other population groups worldwide, investigated Serbian population had up to 15 times reduced content of Se. Despite the difference in metal's profile according to biological variables, this study also demonstrated, for the first time, that each thyroid disease has its unique metal's profile. The most altered metal's content was found in tissues with HT. Contrarily, the greatest similarity in metal's content with HTTs was found in BT tissues. Based on the increased content, metal's that dominantly discriminated HTTs from the HT, MNG and TC was As, Pb and Cd, respectively. Reported results could highlight the role of toxic and essential trace metals in the not very well clarified etiology of thyroid diseases and, moreover, could provide a molecular basis for pathophysiological changes of metal's hazardous effects on thyroid health at the tissue level.",
publisher = "Elsevier",
journal = "Ecotoxicology and Environmental Safety",
title = "Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases",
volume = "183",
doi = "10.1016/j.ecoenv.2019.109479"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Kodranov, I. D., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases.
Ecotoxicology and Environmental Safety
Elsevier., 183.
https://doi.org/10.1016/j.ecoenv.2019.109479
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Kodranov ID, Gavrović-Jankulović M, Manojlović DD. Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases. Ecotoxicology and Environmental Safety. 2019;183
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Borković-Mitić Slavica S., Paunović Ivan, Kodranov Igor D., Gavrović-Jankulović Marija, Manojlović Dragan D., "Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases" Ecotoxicology and Environmental Safety, 183 (2019),
https://doi.org/10.1016/j.ecoenv.2019.109479 .
14
9
13

Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Borković-Mitić, Slavica S.; Paunović, Ivan; Kodranov, Igor D.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Kodranov, Igor D.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3286
PB  - Elsevier
T2  - Ecotoxicology and Environmental Safety
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Borković-Mitić, Slavica S. and Paunović, Ivan and Kodranov, Igor D. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3286",
publisher = "Elsevier",
journal = "Ecotoxicology and Environmental Safety",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Borković-Mitić, S. S., Paunović, I., Kodranov, I. D., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479.
Ecotoxicology and Environmental Safety
Elsevier..
Stojsavljević A, Rovčanin B, Krstić ĐD, Borković-Mitić SS, Paunović I, Kodranov ID, Gavrović-Jankulović M, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479. Ecotoxicology and Environmental Safety. 2019;
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Borković-Mitić Slavica S., Paunović Ivan, Kodranov Igor D., Gavrović-Jankulović Marija, Manojlović Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, B.; Krstić, Đ.; Borković-Mitić, S.; Paunović, I.; Kodranov, I.; Gavrović-Jankulović, M.; Manojlović, D. Evaluation of  Trace Metals in Thyroid Tissues: Comparative Analysis with Benign and Malignant Thyroid Diseases. Ecotoxicology and Environmental Safety 2019, 183. https://doi.org/10.1016/j.ecoenv.2019.109479" Ecotoxicology and Environmental Safety (2019)

Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Jagodić, Jovana; Borković-Mitić, Slavica S.; Paunović, Ivan; Živaljević, Vladan; Mitić, Bojan M.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Jagodić, Jovana
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Mitić, Bojan M.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3293
AB  - Background: The etiology of papillary thyroid carcinoma (PTC) is unknown and some literature data support the hypothesis that heavy metals, as endocrine disrupters, could play a major role in the pathogenesis of thyroid cancer. This study aimed to estimate the content of selected toxic and essential trace metals (Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U), as well as the selected ratio's (Cu/Zn and Cd/Se) in the malignant thyroid tissues according to sex, age, smoking habits, familial history of any thyroid disease, pathohistological (PH) types of PTC, tumor size, the existence of a thyroid capsular invasion, intrathyroid tumor dissemination, retrosternal thyroid growth, and TNM progress of PTC. Methods: The study included 66 patients with PTC (women/men ratio = 46/20, mean age: 54 ± 14 years). A comparative analysis was made by collecting the healthy thyroid tissues (HTTs) of the same patients, making the total number of samples 132. All trace metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). Results: Metals that significantly separated papillary thyroid tissues (PTTs) from the HTTs were Cd, U and Se (p < 0.05). The obtained negative correlation between Cd and Se in the PTTs could explain extrusion of essential Se caused by increased content of Cd. Only Cd had an influence on the retrosternal thyroid growth, while the essential metals (Mn, Co, and Zn) had an influence on thyroid capsular invasion. Conclusion: It was found that Cd act as the main endocrine disrupter, which could highlight its role in the etiology of PTC. Considering that the Cd/Se ratio significantly separated two studied groups and had an influence on the retrosternal thyroid growth, its altered content could contribute to the better understanding of the molecular basis for pathophysiological changes in the PTC.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology
VL  - 55
SP  - 190
EP  - 195
DO  - 10.1016/j.jtemb.2019.06.009
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Jagodić, Jovana and Borković-Mitić, Slavica S. and Paunović, Ivan and Živaljević, Vladan and Mitić, Bojan M. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3293",
abstract = "Background: The etiology of papillary thyroid carcinoma (PTC) is unknown and some literature data support the hypothesis that heavy metals, as endocrine disrupters, could play a major role in the pathogenesis of thyroid cancer. This study aimed to estimate the content of selected toxic and essential trace metals (Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb, Th, and U), as well as the selected ratio's (Cu/Zn and Cd/Se) in the malignant thyroid tissues according to sex, age, smoking habits, familial history of any thyroid disease, pathohistological (PH) types of PTC, tumor size, the existence of a thyroid capsular invasion, intrathyroid tumor dissemination, retrosternal thyroid growth, and TNM progress of PTC. Methods: The study included 66 patients with PTC (women/men ratio = 46/20, mean age: 54 ± 14 years). A comparative analysis was made by collecting the healthy thyroid tissues (HTTs) of the same patients, making the total number of samples 132. All trace metals were quantified by inductively coupled plasma-mass spectrometry (ICP-MS). Results: Metals that significantly separated papillary thyroid tissues (PTTs) from the HTTs were Cd, U and Se (p < 0.05). The obtained negative correlation between Cd and Se in the PTTs could explain extrusion of essential Se caused by increased content of Cd. Only Cd had an influence on the retrosternal thyroid growth, while the essential metals (Mn, Co, and Zn) had an influence on thyroid capsular invasion. Conclusion: It was found that Cd act as the main endocrine disrupter, which could highlight its role in the etiology of PTC. Considering that the Cd/Se ratio significantly separated two studied groups and had an influence on the retrosternal thyroid growth, its altered content could contribute to the better understanding of the molecular basis for pathophysiological changes in the PTC.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology",
volume = "55",
pages = "190-195",
doi = "10.1016/j.jtemb.2019.06.009"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Jagodić, J., Borković-Mitić, S. S., Paunović, I., Živaljević, V., Mitić, B. M., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology.
Journal of Trace Elements in Medicine and Biology
Elsevier., 55, 190-195.
https://doi.org/10.1016/j.jtemb.2019.06.009
Stojsavljević A, Rovčanin B, Krstić ĐD, Jagodić J, Borković-Mitić SS, Paunović I, Živaljević V, Mitić BM, Gavrović-Jankulović M, Manojlović DD. Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology. Journal of Trace Elements in Medicine and Biology. 2019;55:190-195
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Jagodić Jovana, Borković-Mitić Slavica S., Paunović Ivan, Živaljević Vladan, Mitić Bojan M., Gavrović-Jankulović Marija, Manojlović Dragan D., "Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology" Journal of Trace Elements in Medicine and Biology, 55 (2019):190-195,
https://doi.org/10.1016/j.jtemb.2019.06.009 .
13
5
13

Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa D.; Jagodić, Jovana; Borković-Mitić, Slavica S.; Paunović, Ivan; Živaljević, Vladan; Mitić, Bojan M.; Gavrović-Jankulović, Marija; Manojlović, Dragan D.

(Elsevier, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Jagodić, Jovana
AU  - Borković-Mitić, Slavica S.
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Mitić, Bojan M.
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3294
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Krstić, Đurđa D. and Jagodić, Jovana and Borković-Mitić, Slavica S. and Paunović, Ivan and Živaljević, Vladan and Mitić, Bojan M. and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3294",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009"
}
Stojsavljević, A., Rovčanin, B., Krstić, Đ. D., Jagodić, J., Borković-Mitić, S. S., Paunović, I., Živaljević, V., Mitić, B. M., Gavrović-Jankulović, M.,& Manojlović, D. D. (2019). Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009.
Journal of Trace Elements in Medicine and Biology
Elsevier..
Stojsavljević A, Rovčanin B, Krstić ĐD, Jagodić J, Borković-Mitić SS, Paunović I, Živaljević V, Mitić BM, Gavrović-Jankulović M, Manojlović DD. Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009. Journal of Trace Elements in Medicine and Biology. 2019;
Stojsavljević Aleksandar, Rovčanin Branislav, Krstić Đurđa D., Jagodić Jovana, Borković-Mitić Slavica S., Paunović Ivan, Živaljević Vladan, Mitić Bojan M., Gavrović-Jankulović Marija, Manojlović Dragan D., "Supplementary material for the article: Stojsavljević, A.; Rovčanin, B.; Krstić; Jagodić, J.; Borković-Mitić, S.; Paunović, I.; Živaljević, V.; Mitić, B.; Gavrović-Jankulović, M.; Manojlović, D. Cadmium as Main Endocrine Disruptor in Papillary Thyroid Carcinoma and the Significance of Cd/Se Ratio for Thyroid Tissue Pathophysiology. Journal of Trace Elements in Medicine and Biology 2019, 55, 190–195. https://doi.org/10.1016/j.jtemb.2019.06.009" Journal of Trace Elements in Medicine and Biology (2019)

The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples

Stojsavljević, Aleksandar; Škrivanj, Sandra B.; Trifković, Jelena; Đoković, Nenad; Trifunović, Srećko R.; Borković-Mitić, Slavica S.; Manojlović, Dragan D.

(Springer, 2019)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Škrivanj, Sandra B.
AU  - Trifković, Jelena
AU  - Đoković, Nenad
AU  - Trifunović, Srećko R.
AU  - Borković-Mitić, Slavica S.
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3687
AB  - Pollution caused by heavy metals affects all forms of life. The aim of the study was to determine the content of toxic (Sr, Ni, Pb, V, Cd, U, Rb, As) and essential (Na, K, Ca, Mg, Zn, Cu, Se, Mn, Cr, Mo, Co) metals in the bone and whole blood samples, in regard to clinical means of long- and short-term exposure, respectively. For this purpose, the cortical and trabecular parts of femoral neck, as well as the blood samples, were collected to quantify bone-important metals by inductively coupled plasma (ICP)-based techniques. According to principal component analysis (PCA), the most influential metal discriminating blood samples was Cu, while all other quantified elements were present in higher amounts in the bones. Additionally, trabecular bones (TBs) could be characterized by higher content of Mo, Cr, V, Mn, Co, As, and Ni compared to cortical bones (CBs). Linear discrimination analysis (LDA) was successfully applied to distinguish trabecular bone from the cortical bone. Significant correlation between essential Ca and toxic Sr with other elements was found and discussed. This study provides novel data on the effects of metal pollutants on bone health hazards. The results obtained for investigating metals may serve as a baseline for further clinical investigations in the orthopedic fields.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples
VL  - 26
IS  - 16
SP  - 16577
EP  - 16587
DO  - 10.1007/s11356-019-04796-w
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Škrivanj, Sandra B. and Trifković, Jelena and Đoković, Nenad and Trifunović, Srećko R. and Borković-Mitić, Slavica S. and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3687",
abstract = "Pollution caused by heavy metals affects all forms of life. The aim of the study was to determine the content of toxic (Sr, Ni, Pb, V, Cd, U, Rb, As) and essential (Na, K, Ca, Mg, Zn, Cu, Se, Mn, Cr, Mo, Co) metals in the bone and whole blood samples, in regard to clinical means of long- and short-term exposure, respectively. For this purpose, the cortical and trabecular parts of femoral neck, as well as the blood samples, were collected to quantify bone-important metals by inductively coupled plasma (ICP)-based techniques. According to principal component analysis (PCA), the most influential metal discriminating blood samples was Cu, while all other quantified elements were present in higher amounts in the bones. Additionally, trabecular bones (TBs) could be characterized by higher content of Mo, Cr, V, Mn, Co, As, and Ni compared to cortical bones (CBs). Linear discrimination analysis (LDA) was successfully applied to distinguish trabecular bone from the cortical bone. Significant correlation between essential Ca and toxic Sr with other elements was found and discussed. This study provides novel data on the effects of metal pollutants on bone health hazards. The results obtained for investigating metals may serve as a baseline for further clinical investigations in the orthopedic fields.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples",
volume = "26",
number = "16",
pages = "16577-16587",
doi = "10.1007/s11356-019-04796-w"
}
Stojsavljević, A., Škrivanj, S. B., Trifković, J., Đoković, N., Trifunović, S. R., Borković-Mitić, S. S.,& Manojlović, D. D. (2019). The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples.
Environmental Science and Pollution Research
Springer., 26(16), 16577-16587.
https://doi.org/10.1007/s11356-019-04796-w
Stojsavljević A, Škrivanj SB, Trifković J, Đoković N, Trifunović SR, Borković-Mitić SS, Manojlović DD. The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples. Environmental Science and Pollution Research. 2019;26(16):16577-16587
Stojsavljević Aleksandar, Škrivanj Sandra B., Trifković Jelena, Đoković Nenad, Trifunović Srećko R., Borković-Mitić Slavica S., Manojlović Dragan D., "The content of toxic and essential elements in trabecular and cortical femoral neck: a correlation with whole blood samples" Environmental Science and Pollution Research, 26, no. 16 (2019):16577-16587,
https://doi.org/10.1007/s11356-019-04796-w .
2
1
2

Supplementary data for the article: Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w

Stojsavljević, Aleksandar; Škrivanj, Sandra B.; Trifković, Jelena; Đoković, Nenad; Trifunović, Srećko R.; Borković-Mitić, Slavica S.; Manojlović, Dragan D.

(Springer, 2019)

TY  - BOOK
AU  - Stojsavljević, Aleksandar
AU  - Škrivanj, Sandra B.
AU  - Trifković, Jelena
AU  - Đoković, Nenad
AU  - Trifunović, Srećko R.
AU  - Borković-Mitić, Slavica S.
AU  - Manojlović, Dragan D.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3688
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w
DO  - 10.1007/s11356-019-04796-w
ER  - 
@book{
author = "Stojsavljević, Aleksandar and Škrivanj, Sandra B. and Trifković, Jelena and Đoković, Nenad and Trifunović, Srećko R. and Borković-Mitić, Slavica S. and Manojlović, Dragan D.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3688",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w",
doi = "10.1007/s11356-019-04796-w"
}
Stojsavljević, A., Škrivanj, S. B., Trifković, J., Đoković, N., Trifunović, S. R., Borković-Mitić, S. S.,& Manojlović, D. D. (2019). Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w.
Environmental Science and Pollution Research
Springer..
https://doi.org/10.1007/s11356-019-04796-w
Stojsavljević A, Škrivanj SB, Trifković J, Đoković N, Trifunović SR, Borković-Mitić SS, Manojlović DD. Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w. Environmental Science and Pollution Research. 2019;
Stojsavljević Aleksandar, Škrivanj Sandra B., Trifković Jelena, Đoković Nenad, Trifunović Srećko R., Borković-Mitić Slavica S., Manojlović Dragan D., "Supplementary data for the article:  Stojsavljević, A.; Škrivanj, S.; Trifković, J.; Djoković, N.; Trifunović, S. R.; Borković-Mitić, S.; Manojlović, D. The Content of Toxic and Essential Elements in Trabecular and Cortical Femoral Neck: A Correlation with Whole Blood Samples. Environmental Science and Pollution Research 2019, 26 (16), 16577–16587. https://doi.org/10.1007/s11356-019-04796-w" Environmental Science and Pollution Research (2019),
https://doi.org/10.1007/s11356-019-04796-w .
2
1
2

The effects of meldonium on the renal acute ischemia/reperfusion injury in rats

Đurašević, Siniša; Stojković, Maja; Bogdanović, Ljiljana; Pavlović, Slađan Z.; Borković-Mitić, Slavica S.; Grigorov, Ilijana; Bogojević, Desanka; Jasnić, Nebojša; Tosti, Tomislav; Đurović, Saša; Đorđević, Jelena; Todorović, Zoran B.

(MDPI, 2019)

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Stojković, Maja
AU  - Bogdanović, Ljiljana
AU  - Pavlović, Slađan Z.
AU  - Borković-Mitić, Slavica S.
AU  - Grigorov, Ilijana
AU  - Bogojević, Desanka
AU  - Jasnić, Nebojša
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran B.
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3767
AB  - Acute renal ischemia/reperfusion (I/R) injury is a clinical condition that is challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, in this study we investigated the effects of a four-week meldonium pre-treatment (300 mg/kg b.m./day) on acute renal I/R in male rats (Wistar strain). Our results showed that meldonium decreased animal body mass gain, food and water intake, and carnitine, glucose, and lactic acid kidney content. In kidneys of animals subjected to I/R, meldonium increased phosphorylation of mitogen-activated protein kinase p38 and protein kinase B, and increased the expression of nuclear factor erythroid 2-related factor 2 and haeme oxygenase 1, causing manganese superoxide dismutase expression and activity to increase, as well as lipid peroxidation, cooper-zinc superoxide dismutase, glutathione peroxidase, and glutathione reductase activities to decrease. By decreasing the kidney Bax/Bcl2 expression ratio and kidney and serum high mobility group box 1 protein content, meldonium reduced apoptotic and necrotic events in I/R, as confirmed by kidney histology. Meldonium increased adrenal noradrenaline content and serum, adrenal, hepatic, and renal ascorbic/dehydroascorbic acid ratio, which caused complex changes in renal lipidomics. Taken together, our results have confirmed that meldonium pretreatment protects against I/R-induced oxidative stress and apoptosis/necrosis.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - The effects of meldonium on the renal acute ischemia/reperfusion injury in rats
VL  - 20
IS  - 22
DO  - 10.3390/ijms20225747
ER  - 
@article{
author = "Đurašević, Siniša and Stojković, Maja and Bogdanović, Ljiljana and Pavlović, Slađan Z. and Borković-Mitić, Slavica S. and Grigorov, Ilijana and Bogojević, Desanka and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Đorđević, Jelena and Todorović, Zoran B.",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3767",
abstract = "Acute renal ischemia/reperfusion (I/R) injury is a clinical condition that is challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, in this study we investigated the effects of a four-week meldonium pre-treatment (300 mg/kg b.m./day) on acute renal I/R in male rats (Wistar strain). Our results showed that meldonium decreased animal body mass gain, food and water intake, and carnitine, glucose, and lactic acid kidney content. In kidneys of animals subjected to I/R, meldonium increased phosphorylation of mitogen-activated protein kinase p38 and protein kinase B, and increased the expression of nuclear factor erythroid 2-related factor 2 and haeme oxygenase 1, causing manganese superoxide dismutase expression and activity to increase, as well as lipid peroxidation, cooper-zinc superoxide dismutase, glutathione peroxidase, and glutathione reductase activities to decrease. By decreasing the kidney Bax/Bcl2 expression ratio and kidney and serum high mobility group box 1 protein content, meldonium reduced apoptotic and necrotic events in I/R, as confirmed by kidney histology. Meldonium increased adrenal noradrenaline content and serum, adrenal, hepatic, and renal ascorbic/dehydroascorbic acid ratio, which caused complex changes in renal lipidomics. Taken together, our results have confirmed that meldonium pretreatment protects against I/R-induced oxidative stress and apoptosis/necrosis.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "The effects of meldonium on the renal acute ischemia/reperfusion injury in rats",
volume = "20",
number = "22",
doi = "10.3390/ijms20225747"
}
Đurašević, S., Stojković, M., Bogdanović, L., Pavlović, S. Z., Borković-Mitić, S. S., Grigorov, I., Bogojević, D., Jasnić, N., Tosti, T., Đurović, S., Đorđević, J.,& Todorović, Z. B. (2019). The effects of meldonium on the renal acute ischemia/reperfusion injury in rats.
International Journal of Molecular Sciences
MDPI., 20(22).
https://doi.org/10.3390/ijms20225747
Đurašević S, Stojković M, Bogdanović L, Pavlović SZ, Borković-Mitić SS, Grigorov I, Bogojević D, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović ZB. The effects of meldonium on the renal acute ischemia/reperfusion injury in rats. International Journal of Molecular Sciences. 2019;20(22)
Đurašević Siniša, Stojković Maja, Bogdanović Ljiljana, Pavlović Slađan Z., Borković-Mitić Slavica S., Grigorov Ilijana, Bogojević Desanka, Jasnić Nebojša, Tosti Tomislav, Đurović Saša, Đorđević Jelena, Todorović Zoran B., "The effects of meldonium on the renal acute ischemia/reperfusion injury in rats" International Journal of Molecular Sciences, 20, no. 22 (2019),
https://doi.org/10.3390/ijms20225747 .
5
4

Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals

Prokić, Marko D.; Borković-Mitić, Slavica S.; Krizmanić, Imre I.; Mutić, Jelena; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Elsevier Science Inc, New York, 2017)

TY  - JOUR
AU  - Prokić, Marko D.
AU  - Borković-Mitić, Slavica S.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2548
AB  - In spring, frogs from temperate regions are faced with arousal-induced oxidative stress and exposure to various xenobiotics from the environment. The question is whether pollutants can significantly modify the antioxidative defense system (AOS) response of hibernators during recovery from hibernation. If this assumption is true, we would then expect different patterns of seasonal variations in the AOS between individuals exposed to different levels of pollution. To examine this assumption, we determined the relationship between seasonal variations of accumulated metals and AOS parameters in the skin and muscle of two frog species from the Pelophylax esculentus complex (P. ridibundus and P. esculentus) inhabiting two localities (the Danube-Tisza-Danube canal and the Ponjavica River) with different levels of pollution during pre- and post-hibernation periods, respectively autumn and spring. Our results showed that even though there were differences in the concentrations of accumulated metals and AOS parameters between localities and species, the frogs displayed almost the same patterns of AOS variations during seasons, with a higher AOS response observed in spring. The parameters SH groups, GSH, GR and SOD had been contributed most rather than others. Our findings indicate that oxidative stress during the post-hibernation period was mainly caused by the organisms' recovery from hibernation, as the result of natural selection acting on the AOS, and that the accumulated metals did not significantly, modify the AOS response. The present study provides new insight into the biological and physiological cellular responses of frogs to arousal stress.
PB  - Elsevier Science Inc, New York
T2  - Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology
T1  - Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals
VL  - 202
SP  - 19
EP  - 25
DO  - 10.1016/j.cbpc.2017.07.006
ER  - 
@article{
author = "Prokić, Marko D. and Borković-Mitić, Slavica S. and Krizmanić, Imre I. and Mutić, Jelena and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2548",
abstract = "In spring, frogs from temperate regions are faced with arousal-induced oxidative stress and exposure to various xenobiotics from the environment. The question is whether pollutants can significantly modify the antioxidative defense system (AOS) response of hibernators during recovery from hibernation. If this assumption is true, we would then expect different patterns of seasonal variations in the AOS between individuals exposed to different levels of pollution. To examine this assumption, we determined the relationship between seasonal variations of accumulated metals and AOS parameters in the skin and muscle of two frog species from the Pelophylax esculentus complex (P. ridibundus and P. esculentus) inhabiting two localities (the Danube-Tisza-Danube canal and the Ponjavica River) with different levels of pollution during pre- and post-hibernation periods, respectively autumn and spring. Our results showed that even though there were differences in the concentrations of accumulated metals and AOS parameters between localities and species, the frogs displayed almost the same patterns of AOS variations during seasons, with a higher AOS response observed in spring. The parameters SH groups, GSH, GR and SOD had been contributed most rather than others. Our findings indicate that oxidative stress during the post-hibernation period was mainly caused by the organisms' recovery from hibernation, as the result of natural selection acting on the AOS, and that the accumulated metals did not significantly, modify the AOS response. The present study provides new insight into the biological and physiological cellular responses of frogs to arousal stress.",
publisher = "Elsevier Science Inc, New York",
journal = "Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology",
title = "Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals",
volume = "202",
pages = "19-25",
doi = "10.1016/j.cbpc.2017.07.006"
}
Prokić, M. D., Borković-Mitić, S. S., Krizmanić, I. I., Mutić, J., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2017). Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals.
Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology
Elsevier Science Inc, New York., 202, 19-25.
https://doi.org/10.1016/j.cbpc.2017.07.006
Prokić MD, Borković-Mitić SS, Krizmanić II, Mutić J, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology. 2017;202:19-25
Prokić Marko D., Borković-Mitić Slavica S., Krizmanić Imre I., Mutić Jelena, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals" Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology, 202 (2017):19-25,
https://doi.org/10.1016/j.cbpc.2017.07.006 .
10
9
10

Supplementary data for article : Prokic, M. D.; Borkovic-Mitic, S. S.; Krizmanic, I. I.; Mutić, J.; Gavric, J. P.; Despotovic, S. G.; Gavrilović, B. R.; Radovanovic, T. B.; Pavlovic, S. Z.; Saicic, Z. S. Oxidative Stress Parameters in Two Pelophylax Esculentus Complex Frogs during Pre- and Post-Hibernation: Arousal vs Heavy Metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology 2017, 202, 19–25.https://doi.org/10.1016/j.cbpc.2017.07.00

Prokić, Marko D.; Borković-Mitić, Slavica S.; Krizmanić, Imre I.; Mutić, Jelena; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Elsevier Science Inc, New York, 2017)

TY  - BOOK
AU  - Prokić, Marko D.
AU  - Borković-Mitić, Slavica S.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2017
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2962
PB  - Elsevier Science Inc, New York
T2  - Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology
T1  - Supplementary data for article :              Prokic, M. D.; Borkovic-Mitic, S. S.; Krizmanic, I. I.; Mutić, J.; Gavric, J. P.; Despotovic, S. G.; Gavrilović, B. R.; Radovanovic, T. B.; Pavlovic, S. Z.; Saicic, Z. S. Oxidative Stress Parameters in Two Pelophylax Esculentus Complex Frogs during Pre- and Post-Hibernation: Arousal vs Heavy Metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology 2017, 202, 19–25.https://doi.org/10.1016/j.cbpc.2017.07.00
ER  - 
@book{
author = "Prokić, Marko D. and Borković-Mitić, Slavica S. and Krizmanić, Imre I. and Mutić, Jelena and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2017, 2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2962",
publisher = "Elsevier Science Inc, New York",
journal = "Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology",
title = "Supplementary data for article :              Prokic, M. D.; Borkovic-Mitic, S. S.; Krizmanic, I. I.; Mutić, J.; Gavric, J. P.; Despotovic, S. G.; Gavrilović, B. R.; Radovanovic, T. B.; Pavlovic, S. Z.; Saicic, Z. S. Oxidative Stress Parameters in Two Pelophylax Esculentus Complex Frogs during Pre- and Post-Hibernation: Arousal vs Heavy Metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology 2017, 202, 19–25.https://doi.org/10.1016/j.cbpc.2017.07.00"
}
Prokić, M. D., Borković-Mitić, S. S., Krizmanić, I. I., Mutić, J., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2017). Supplementary data for article :              Prokic, M. D.; Borkovic-Mitic, S. S.; Krizmanic, I. I.; Mutić, J.; Gavric, J. P.; Despotovic, S. G.; Gavrilović, B. R.; Radovanovic, T. B.; Pavlovic, S. Z.; Saicic, Z. S. Oxidative Stress Parameters in Two Pelophylax Esculentus Complex Frogs during Pre- and Post-Hibernation: Arousal vs Heavy Metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology 2017, 202, 19–25.https://doi.org/10.1016/j.cbpc.2017.07.00.
Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology
Elsevier Science Inc, New York..
Prokić MD, Borković-Mitić SS, Krizmanić II, Mutić J, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Supplementary data for article :              Prokic, M. D.; Borkovic-Mitic, S. S.; Krizmanic, I. I.; Mutić, J.; Gavric, J. P.; Despotovic, S. G.; Gavrilović, B. R.; Radovanovic, T. B.; Pavlovic, S. Z.; Saicic, Z. S. Oxidative Stress Parameters in Two Pelophylax Esculentus Complex Frogs during Pre- and Post-Hibernation: Arousal vs Heavy Metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology 2017, 202, 19–25.https://doi.org/10.1016/j.cbpc.2017.07.00. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology. 2017;
Prokić Marko D., Borković-Mitić Slavica S., Krizmanić Imre I., Mutić Jelena, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Supplementary data for article :              Prokic, M. D.; Borkovic-Mitic, S. S.; Krizmanic, I. I.; Mutić, J.; Gavric, J. P.; Despotovic, S. G.; Gavrilović, B. R.; Radovanovic, T. B.; Pavlovic, S. Z.; Saicic, Z. S. Oxidative Stress Parameters in Two Pelophylax Esculentus Complex Frogs during Pre- and Post-Hibernation: Arousal vs Heavy Metals. Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology 2017, 202, 19–25.https://doi.org/10.1016/j.cbpc.2017.07.00" Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology (2017)

Supplementary data for the article: Prokić, M. D.; Borković-Mitić, S. S.; Krizmanić, I. I.; Mutić, J. J.; Trifković, J. Đ.; Gavrić, J. P.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Bioaccumulation and Effects of Metals on Oxidative Stress and Neurotoxicity Parameters in the Frogs from the Pelophylax Esculentus Complex. Ecotoxicology 2016, 25 (8), 1531–1542. https://doi.org/10.1007/s10646-016-1707-x

Prokić, Marko D.; Borković-Mitić, Slavica S.; Krizmanić, Imre I.; Mutić, Jelena; Trifković, Jelena; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Springer, Dordrecht, 2016)

TY  - BOOK
AU  - Prokić, Marko D.
AU  - Borković-Mitić, Slavica S.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Trifković, Jelena
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3391
PB  - Springer, Dordrecht
T2  - Ecotoxicology
T1  - Supplementary data for the article: Prokić, M. D.; Borković-Mitić, S. S.; Krizmanić, I. I.; Mutić, J. J.; Trifković, J. Đ.; Gavrić, J. P.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Bioaccumulation and Effects of Metals on Oxidative Stress and Neurotoxicity Parameters in the Frogs from the Pelophylax Esculentus Complex. Ecotoxicology 2016, 25 (8), 1531–1542. https://doi.org/10.1007/s10646-016-1707-x
ER  - 
@book{
author = "Prokić, Marko D. and Borković-Mitić, Slavica S. and Krizmanić, Imre I. and Mutić, Jelena and Trifković, Jelena and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3391",
publisher = "Springer, Dordrecht",
journal = "Ecotoxicology",
title = "Supplementary data for the article: Prokić, M. D.; Borković-Mitić, S. S.; Krizmanić, I. I.; Mutić, J. J.; Trifković, J. Đ.; Gavrić, J. P.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Bioaccumulation and Effects of Metals on Oxidative Stress and Neurotoxicity Parameters in the Frogs from the Pelophylax Esculentus Complex. Ecotoxicology 2016, 25 (8), 1531–1542. https://doi.org/10.1007/s10646-016-1707-x"
}
Prokić, M. D., Borković-Mitić, S. S., Krizmanić, I. I., Mutić, J., Trifković, J., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2016). Supplementary data for the article: Prokić, M. D.; Borković-Mitić, S. S.; Krizmanić, I. I.; Mutić, J. J.; Trifković, J. Đ.; Gavrić, J. P.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Bioaccumulation and Effects of Metals on Oxidative Stress and Neurotoxicity Parameters in the Frogs from the Pelophylax Esculentus Complex. Ecotoxicology 2016, 25 (8), 1531–1542. https://doi.org/10.1007/s10646-016-1707-x.
Ecotoxicology
Springer, Dordrecht..
Prokić MD, Borković-Mitić SS, Krizmanić II, Mutić J, Trifković J, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Supplementary data for the article: Prokić, M. D.; Borković-Mitić, S. S.; Krizmanić, I. I.; Mutić, J. J.; Trifković, J. Đ.; Gavrić, J. P.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Bioaccumulation and Effects of Metals on Oxidative Stress and Neurotoxicity Parameters in the Frogs from the Pelophylax Esculentus Complex. Ecotoxicology 2016, 25 (8), 1531–1542. https://doi.org/10.1007/s10646-016-1707-x. Ecotoxicology. 2016;
Prokić Marko D., Borković-Mitić Slavica S., Krizmanić Imre I., Mutić Jelena, Trifković Jelena, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Supplementary data for the article: Prokić, M. D.; Borković-Mitić, S. S.; Krizmanić, I. I.; Mutić, J. J.; Trifković, J. Đ.; Gavrić, J. P.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Bioaccumulation and Effects of Metals on Oxidative Stress and Neurotoxicity Parameters in the Frogs from the Pelophylax Esculentus Complex. Ecotoxicology 2016, 25 (8), 1531–1542. https://doi.org/10.1007/s10646-016-1707-x" Ecotoxicology (2016)

Supplementary data for the article: Borković-Mitić, S. S.; Prokić, M. D.; Krizmanić, I. I.; Mutić, J.; Trifković, J.; Gavrić, J.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Biomarkers of Oxidative Stress and Metal Accumulation in Marsh Frog (Pelophylax Ridibundus). Environmental Science and Pollution Research 2016, 23 (10), 9649–9659. https://doi.org/10.1007/s11356-016-6194-3

Borković-Mitić, Slavica S.; Prokić, Marko D.; Krizmanić, Imre I.; Mutić, Jelena; Trifković, Jelena; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Springer Heidelberg, Heidelberg, 2016)

TY  - BOOK
AU  - Borković-Mitić, Slavica S.
AU  - Prokić, Marko D.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Trifković, Jelena
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3392
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Supplementary data for the article: Borković-Mitić, S. S.; Prokić, M. D.; Krizmanić, I. I.; Mutić, J.; Trifković, J.; Gavrić, J.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Biomarkers of Oxidative Stress and Metal Accumulation in Marsh Frog (Pelophylax Ridibundus). Environmental Science and Pollution Research 2016, 23 (10), 9649–9659. https://doi.org/10.1007/s11356-016-6194-3
ER  - 
@book{
author = "Borković-Mitić, Slavica S. and Prokić, Marko D. and Krizmanić, Imre I. and Mutić, Jelena and Trifković, Jelena and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3392",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Supplementary data for the article: Borković-Mitić, S. S.; Prokić, M. D.; Krizmanić, I. I.; Mutić, J.; Trifković, J.; Gavrić, J.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Biomarkers of Oxidative Stress and Metal Accumulation in Marsh Frog (Pelophylax Ridibundus). Environmental Science and Pollution Research 2016, 23 (10), 9649–9659. https://doi.org/10.1007/s11356-016-6194-3"
}
Borković-Mitić, S. S., Prokić, M. D., Krizmanić, I. I., Mutić, J., Trifković, J., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2016). Supplementary data for the article: Borković-Mitić, S. S.; Prokić, M. D.; Krizmanić, I. I.; Mutić, J.; Trifković, J.; Gavrić, J.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Biomarkers of Oxidative Stress and Metal Accumulation in Marsh Frog (Pelophylax Ridibundus). Environmental Science and Pollution Research 2016, 23 (10), 9649–9659. https://doi.org/10.1007/s11356-016-6194-3.
Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg..
Borković-Mitić SS, Prokić MD, Krizmanić II, Mutić J, Trifković J, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Supplementary data for the article: Borković-Mitić, S. S.; Prokić, M. D.; Krizmanić, I. I.; Mutić, J.; Trifković, J.; Gavrić, J.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Biomarkers of Oxidative Stress and Metal Accumulation in Marsh Frog (Pelophylax Ridibundus). Environmental Science and Pollution Research 2016, 23 (10), 9649–9659. https://doi.org/10.1007/s11356-016-6194-3. Environmental Science and Pollution Research. 2016;
Borković-Mitić Slavica S., Prokić Marko D., Krizmanić Imre I., Mutić Jelena, Trifković Jelena, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Supplementary data for the article: Borković-Mitić, S. S.; Prokić, M. D.; Krizmanić, I. I.; Mutić, J.; Trifković, J.; Gavrić, J.; Despotović, S. G.; Gavrilović, B. R.; Radovanović, T. B.; Pavlović, S. Z.; et al. Biomarkers of Oxidative Stress and Metal Accumulation in Marsh Frog (Pelophylax Ridibundus). Environmental Science and Pollution Research 2016, 23 (10), 9649–9659. https://doi.org/10.1007/s11356-016-6194-3" Environmental Science and Pollution Research (2016)

Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex

Prokić, Marko D.; Borković-Mitić, Slavica S.; Krizmanić, Imre I.; Mutić, Jelena; Trifković, Jelena; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Springer, Dordrecht, 2016)

TY  - JOUR
AU  - Prokić, Marko D.
AU  - Borković-Mitić, Slavica S.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Trifković, Jelena
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2340
AB  - Metals are involved in the formation of reactive oxygen species and can induce oxidative stress. The aim of this study was to assess the effects of several metals on oxidative stress in the skin and muscle of the Pelophylax esculentus "complex" frogs (parental species Pelophylax ridibundus, Pelophylax lessonae, and their hybrid Pelophylax esculentus) that inhabit the wetland Obedska Bara in Serbia, and the potential use of these species as bioindicator organisms in biomonitoring studies. The biomarkers of oxidative stress (SOD, CAT, GSH-Px, GR, GST activities and GSH, SH concentrations) and cholinesterase activity were investigated. The concentrations of nine metals (Fe, Cu, Zn, As, Cd, Cr, Hg, Ni, and Pb) were measured in the water and tissues. Correlations were established between metals and biomarkers in the tissues. The results of metal accumulation distinguished the skin of P. lessonae and muscle of P. ridibundus from other P. esculentus complex species. The oxidative stress biomarkers observed in P. ridibundus and P. esculentus had greater similarity than in P. lessonae. The P. lessonae displayed the highest number of correlations between biomarkers and metals. The results of tissue responses revealed that skin was more susceptible to metal-induced oxidative stress, with only exception of As. In the light of these findings, we can suggest the use of P. esculentus complex species as a biomonitoring species in studies of metal accumulation and metal-induced oxidative stress, but with special emphasis on P. lessonae.
PB  - Springer, Dordrecht
T2  - Ecotoxicology
T1  - Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex
VL  - 25
IS  - 8
SP  - 1531
EP  - 1542
DO  - 10.1007/s10646-016-1707-x
ER  - 
@article{
author = "Prokić, Marko D. and Borković-Mitić, Slavica S. and Krizmanić, Imre I. and Mutić, Jelena and Trifković, Jelena and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2340",
abstract = "Metals are involved in the formation of reactive oxygen species and can induce oxidative stress. The aim of this study was to assess the effects of several metals on oxidative stress in the skin and muscle of the Pelophylax esculentus "complex" frogs (parental species Pelophylax ridibundus, Pelophylax lessonae, and their hybrid Pelophylax esculentus) that inhabit the wetland Obedska Bara in Serbia, and the potential use of these species as bioindicator organisms in biomonitoring studies. The biomarkers of oxidative stress (SOD, CAT, GSH-Px, GR, GST activities and GSH, SH concentrations) and cholinesterase activity were investigated. The concentrations of nine metals (Fe, Cu, Zn, As, Cd, Cr, Hg, Ni, and Pb) were measured in the water and tissues. Correlations were established between metals and biomarkers in the tissues. The results of metal accumulation distinguished the skin of P. lessonae and muscle of P. ridibundus from other P. esculentus complex species. The oxidative stress biomarkers observed in P. ridibundus and P. esculentus had greater similarity than in P. lessonae. The P. lessonae displayed the highest number of correlations between biomarkers and metals. The results of tissue responses revealed that skin was more susceptible to metal-induced oxidative stress, with only exception of As. In the light of these findings, we can suggest the use of P. esculentus complex species as a biomonitoring species in studies of metal accumulation and metal-induced oxidative stress, but with special emphasis on P. lessonae.",
publisher = "Springer, Dordrecht",
journal = "Ecotoxicology",
title = "Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex",
volume = "25",
number = "8",
pages = "1531-1542",
doi = "10.1007/s10646-016-1707-x"
}
Prokić, M. D., Borković-Mitić, S. S., Krizmanić, I. I., Mutić, J., Trifković, J., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2016). Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex.
Ecotoxicology
Springer, Dordrecht., 25(8), 1531-1542.
https://doi.org/10.1007/s10646-016-1707-x
Prokić MD, Borković-Mitić SS, Krizmanić II, Mutić J, Trifković J, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex. Ecotoxicology. 2016;25(8):1531-1542
Prokić Marko D., Borković-Mitić Slavica S., Krizmanić Imre I., Mutić Jelena, Trifković Jelena, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex" Ecotoxicology, 25, no. 8 (2016):1531-1542,
https://doi.org/10.1007/s10646-016-1707-x .
1
9
6
9

Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)

Borković-Mitić, Slavica S.; Prokić, Marko D.; Krizmanić, Imre I.; Mutić, Jelena; Trifković, Jelena; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Springer Heidelberg, Heidelberg, 2016)

TY  - JOUR
AU  - Borković-Mitić, Slavica S.
AU  - Prokić, Marko D.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Trifković, Jelena
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1941
AB  - To understand the effect of metals on the marsh frog Pelophylax ridibundus and the possible environment-induced changes in oxidative stress enzymes, we determined the concentrations of 18 metals: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, In, Li, Mn, Ni, Pb, Sr, and Zn, in the tissues (liver, skin, and muscle) and water samples collected from different locations in Serbia. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), acetylcholinesterase (AChE), and changes in concentrations of reduced glutathione (GSH) and sulfhydryl groups (SH) were analyzed in the tissues of the sampled frogs. The concentrations of Al, Cd, Co, Cr, Cu, Fe, Ga, Hg, and Ni were highest in the liver, whereas those of Ba, Ca, Li, Mn, Pb, Sr, and Zn were highest in the skin. Hg correlated positively with liver SOD (in frogs from Danube-Tisza-Danube Canal (DTD)), muscle CAT (DTD), and muscle GST Ponjavica River (PO); Pb demonstrated a strong positive correlation with liver GR in frogs from Mt. Fruka Gora (FG); Cd only exhibited a positive correlation with AChE in the skin of frogs from DTD. In the skin, Zn correlated positively with AChE (DTD), SH groups (PO), and CAT (FG), and negatively with CAT, GST, and SH in the liver of frogs from DTD. Examination of these oxidative stress biomarkers, together with analysis of metal accumulation in the liver and skin of marsh frogs, provides a powerful tool for the assessment of metal pollution.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)
VL  - 23
IS  - 10
SP  - 9649
EP  - 9659
DO  - 10.1007/s11356-016-6194-3
ER  - 
@article{
author = "Borković-Mitić, Slavica S. and Prokić, Marko D. and Krizmanić, Imre I. and Mutić, Jelena and Trifković, Jelena and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1941",
abstract = "To understand the effect of metals on the marsh frog Pelophylax ridibundus and the possible environment-induced changes in oxidative stress enzymes, we determined the concentrations of 18 metals: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, In, Li, Mn, Ni, Pb, Sr, and Zn, in the tissues (liver, skin, and muscle) and water samples collected from different locations in Serbia. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), acetylcholinesterase (AChE), and changes in concentrations of reduced glutathione (GSH) and sulfhydryl groups (SH) were analyzed in the tissues of the sampled frogs. The concentrations of Al, Cd, Co, Cr, Cu, Fe, Ga, Hg, and Ni were highest in the liver, whereas those of Ba, Ca, Li, Mn, Pb, Sr, and Zn were highest in the skin. Hg correlated positively with liver SOD (in frogs from Danube-Tisza-Danube Canal (DTD)), muscle CAT (DTD), and muscle GST Ponjavica River (PO); Pb demonstrated a strong positive correlation with liver GR in frogs from Mt. Fruka Gora (FG); Cd only exhibited a positive correlation with AChE in the skin of frogs from DTD. In the skin, Zn correlated positively with AChE (DTD), SH groups (PO), and CAT (FG), and negatively with CAT, GST, and SH in the liver of frogs from DTD. Examination of these oxidative stress biomarkers, together with analysis of metal accumulation in the liver and skin of marsh frogs, provides a powerful tool for the assessment of metal pollution.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)",
volume = "23",
number = "10",
pages = "9649-9659",
doi = "10.1007/s11356-016-6194-3"
}
Borković-Mitić, S. S., Prokić, M. D., Krizmanić, I. I., Mutić, J., Trifković, J., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2016). Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus).
Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 23(10), 9649-9659.
https://doi.org/10.1007/s11356-016-6194-3
Borković-Mitić SS, Prokić MD, Krizmanić II, Mutić J, Trifković J, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus). Environmental Science and Pollution Research. 2016;23(10):9649-9659
Borković-Mitić Slavica S., Prokić Marko D., Krizmanić Imre I., Mutić Jelena, Trifković Jelena, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus)" Environmental Science and Pollution Research, 23, no. 10 (2016):9649-9659,
https://doi.org/10.1007/s11356-016-6194-3 .
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Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution

Prokić, Marko D.; Borković-Mitić, Slavica S.; Krizmanić, Imre I.; Mutić, Jelena; Vukojević, Vesna; Nasia, Mohammed; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Pavlović, Slađan Z.; Saičić, Zorica S.

(Academic Press Inc Elsevier Science, San Diego, 2016)

TY  - JOUR
AU  - Prokić, Marko D.
AU  - Borković-Mitić, Slavica S.
AU  - Krizmanić, Imre I.
AU  - Mutić, Jelena
AU  - Vukojević, Vesna
AU  - Nasia, Mohammed
AU  - Gavrić, Jelena P.
AU  - Despotović, Svetlana G.
AU  - Gavrilović, Branka R.
AU  - Radovanović, Tijana B.
AU  - Pavlović, Slađan Z.
AU  - Saičić, Zorica S.
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1909
AB  - Heavy metal pollution of the aquatic environment is of great concern worldwide. Heavy metals are capable of inducing oxidative stress by increasing the formation of reactive oxygen species (ROS), and directly affecting the antioxidant defense system (AOS) in living organisms. The frog Pelophylax kl. esculentus is a semiaquatic species with semipermeable skin and a complex lifecycle, and represents a potentially useful bioindicator organism. The aim of this study was to investigate the accumulation of several heavy metals (Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb and Zn), and their effects on selected parameters of the AOS, including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), phase II biotransformation enzyme glutathione-S-transferase (GST), the total glutathione (GSH) contents and sulfhydryl (SH) group concentrations, as well as cholinesterases (ChEs) activities in the liver, skin and muscle of P. kl. esculentus. Frog samples were collected at two sites (the Danube-Tisza-Danube canal (DTDC) and the river Ponjavica) in Serbia, which are characterized by different levels of metal pollution. Differences between the metal contents in different tissues showed that the skin of frogs from the DTDC accumulated statistically higher concentrations of Cd, Cu, Pb and Zn, while only the Fe concentration was lower. No significant differences between metal concentrations in muscle tissues of frogs from the DTDC and Ponjavica were observed. Examination of the parameters of the AOS revealed that frogs from the DTDC had higher concentrations of GSH in the liver and of SH groups in the skin and muscle, whereas the activities of the antioxidative enzymes SOD, GHS-Px and GR in the liver and of GR in the skin were lower than in frogs from the Ponjavica. The relationship between metal concentrations and AOS parameters showed the highest number of correlations with GSH, GR and CAT, and with Ni, Zn, Hg, Cr and Cd. Based on the results in this study, we concluded that increased concentrations of heavy metals in frog tissues can alter the AOS, which leads to higher concentrations of GSH and SH groups and lower activities of antioxidative enzymes. The response of the AOS to metal pollutants allowed us to make a distinction between different frog tissues, and to conclude that the liver and skin are more suitable for assessing metal-induced oxidative stress in frogs than muscle. (C) 2016 Elsevier Inc. All rights reserved.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Ecotoxicology and Environmental Safety
T1  - Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution
VL  - 128
SP  - 21
EP  - 29
DO  - 10.1016/j.ecoenv.2016.02.005
ER  - 
@article{
author = "Prokić, Marko D. and Borković-Mitić, Slavica S. and Krizmanić, Imre I. and Mutić, Jelena and Vukojević, Vesna and Nasia, Mohammed and Gavrić, Jelena P. and Despotović, Svetlana G. and Gavrilović, Branka R. and Radovanović, Tijana B. and Pavlović, Slađan Z. and Saičić, Zorica S.",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1909",
abstract = "Heavy metal pollution of the aquatic environment is of great concern worldwide. Heavy metals are capable of inducing oxidative stress by increasing the formation of reactive oxygen species (ROS), and directly affecting the antioxidant defense system (AOS) in living organisms. The frog Pelophylax kl. esculentus is a semiaquatic species with semipermeable skin and a complex lifecycle, and represents a potentially useful bioindicator organism. The aim of this study was to investigate the accumulation of several heavy metals (Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb and Zn), and their effects on selected parameters of the AOS, including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), phase II biotransformation enzyme glutathione-S-transferase (GST), the total glutathione (GSH) contents and sulfhydryl (SH) group concentrations, as well as cholinesterases (ChEs) activities in the liver, skin and muscle of P. kl. esculentus. Frog samples were collected at two sites (the Danube-Tisza-Danube canal (DTDC) and the river Ponjavica) in Serbia, which are characterized by different levels of metal pollution. Differences between the metal contents in different tissues showed that the skin of frogs from the DTDC accumulated statistically higher concentrations of Cd, Cu, Pb and Zn, while only the Fe concentration was lower. No significant differences between metal concentrations in muscle tissues of frogs from the DTDC and Ponjavica were observed. Examination of the parameters of the AOS revealed that frogs from the DTDC had higher concentrations of GSH in the liver and of SH groups in the skin and muscle, whereas the activities of the antioxidative enzymes SOD, GHS-Px and GR in the liver and of GR in the skin were lower than in frogs from the Ponjavica. The relationship between metal concentrations and AOS parameters showed the highest number of correlations with GSH, GR and CAT, and with Ni, Zn, Hg, Cr and Cd. Based on the results in this study, we concluded that increased concentrations of heavy metals in frog tissues can alter the AOS, which leads to higher concentrations of GSH and SH groups and lower activities of antioxidative enzymes. The response of the AOS to metal pollutants allowed us to make a distinction between different frog tissues, and to conclude that the liver and skin are more suitable for assessing metal-induced oxidative stress in frogs than muscle. (C) 2016 Elsevier Inc. All rights reserved.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Ecotoxicology and Environmental Safety",
title = "Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution",
volume = "128",
pages = "21-29",
doi = "10.1016/j.ecoenv.2016.02.005"
}
Prokić, M. D., Borković-Mitić, S. S., Krizmanić, I. I., Mutić, J., Vukojević, V., Nasia, M., Gavrić, J. P., Despotović, S. G., Gavrilović, B. R., Radovanović, T. B., Pavlović, S. Z.,& Saičić, Z. S. (2016). Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution.
Ecotoxicology and Environmental Safety
Academic Press Inc Elsevier Science, San Diego., 128, 21-29.
https://doi.org/10.1016/j.ecoenv.2016.02.005
Prokić MD, Borković-Mitić SS, Krizmanić II, Mutić J, Vukojević V, Nasia M, Gavrić JP, Despotović SG, Gavrilović BR, Radovanović TB, Pavlović SZ, Saičić ZS. Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution. Ecotoxicology and Environmental Safety. 2016;128:21-29
Prokić Marko D., Borković-Mitić Slavica S., Krizmanić Imre I., Mutić Jelena, Vukojević Vesna, Nasia Mohammed, Gavrić Jelena P., Despotović Svetlana G., Gavrilović Branka R., Radovanović Tijana B., Pavlović Slađan Z., Saičić Zorica S., "Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution" Ecotoxicology and Environmental Safety, 128 (2016):21-29,
https://doi.org/10.1016/j.ecoenv.2016.02.005 .
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