TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Lakićević, Novak
AU  - Pavlović, Slađan Z.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6455
AB  - Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and harmful effects on the central nervous system. In this study, we present a comprehensive review and meta-analysis of peer-reviewed research encompassing five crucial clinical matrices: hair, whole blood, plasma, red blood cells (RBCs), and urine. We assess the disparities in Hg levels between gender- and age-matched neurotypical children (controls) and children diagnosed with autism spectrum disorder (ASD) (cases). After applying rigorous selection criteria, we incorporated a total of 60 case-control studies into our meta-analysis. These studies comprised 25 investigations of Hg levels in hair (controls/cases: 1134/1361), 15 in whole blood (controls/cases: 1019/1345), 6 in plasma (controls/cases: 224/263), 5 in RBCs (controls/cases: 215/293), and 9 in urine (controls/cases: 399/623). This meta-analysis did not include the data of ASD children who received chelation therapy. Our meta-analysis revealed no statistically significant differences in Hg levels in hair and urine between ASD cases and controls. In whole blood, plasma, and RBCs, Hg levels were significantly higher in ASD cases compared to their neurotypical counterparts. This indicates that ASD children could exhibit reduced detoxification capacity for Hg and impaired mechanisms for Hg excretion from their bodies. This underscores the detrimental role of Hg in ASD and underscores the critical importance of monitoring Hg levels in ASD children, particularly in early childhood. These findings emphasize the pressing need for global initiatives aimed at minimizing Hg exposure, thus highlighting the critical intersection of human–environment interaction and neurodevelopment health.
T2  - Biomedicines
T1  - Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis
VL  - 11
IS  - 12
SP  - 3344
DO  - 10.3390/biomedicines11123344
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Lakićević, Novak and Pavlović, Slađan Z.",
year = "2023",
abstract = "Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and harmful effects on the central nervous system. In this study, we present a comprehensive review and meta-analysis of peer-reviewed research encompassing five crucial clinical matrices: hair, whole blood, plasma, red blood cells (RBCs), and urine. We assess the disparities in Hg levels between gender- and age-matched neurotypical children (controls) and children diagnosed with autism spectrum disorder (ASD) (cases). After applying rigorous selection criteria, we incorporated a total of 60 case-control studies into our meta-analysis. These studies comprised 25 investigations of Hg levels in hair (controls/cases: 1134/1361), 15 in whole blood (controls/cases: 1019/1345), 6 in plasma (controls/cases: 224/263), 5 in RBCs (controls/cases: 215/293), and 9 in urine (controls/cases: 399/623). This meta-analysis did not include the data of ASD children who received chelation therapy. Our meta-analysis revealed no statistically significant differences in Hg levels in hair and urine between ASD cases and controls. In whole blood, plasma, and RBCs, Hg levels were significantly higher in ASD cases compared to their neurotypical counterparts. This indicates that ASD children could exhibit reduced detoxification capacity for Hg and impaired mechanisms for Hg excretion from their bodies. This underscores the detrimental role of Hg in ASD and underscores the critical importance of monitoring Hg levels in ASD children, particularly in early childhood. These findings emphasize the pressing need for global initiatives aimed at minimizing Hg exposure, thus highlighting the critical intersection of human–environment interaction and neurodevelopment health.",
journal = "Biomedicines",
title = "Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis",
volume = "11",
number = "12",
pages = "3344",
doi = "10.3390/biomedicines11123344"
}

Stojsavljević, A., Lakićević, N.,& Pavlović, S. Z.. (2023). Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis. in Biomedicines, 11(12), 3344.
https://doi.org/10.3390/biomedicines11123344

Stojsavljević A, Lakićević N, Pavlović SZ. Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis. in Biomedicines. 2023;11(12):3344.
doi:10.3390/biomedicines11123344 .

Stojsavljević, Aleksandar, Lakićević, Novak, Pavlović, Slađan Z., "Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis" in Biomedicines, 11, no. 12 (2023):3344,
https://doi.org/10.3390/biomedicines11123344 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Lakićević, Novak
AU  - Pavlović, Slađan Z.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6365
AB  - Environmental pollutants, particularly toxic trace metals with neurotoxic potential, have been related to the genesis of autism. One of these metals that stands out, in particular, is lead (Pb). We conducted an in-depth systematic review and meta-analysis of peer-reviewed studies on Pb levels in biological materials retrieved from autistic children (cases) and neurotypical children (controls) in this work. A systematic review was conducted after the careful selection of published studies according to established criteria to gain a broad insight into the higher or lower levels of Pb in the biological materials of cases and controls, and the findings were then strengthened by a meta-analysis. The meta-analysis included 17 studies (hair), 13 studies (whole blood), and 8 studies (urine). The overall number of controls/cases was 869/915 (hair), 670/755 (whole blood), and 344/373 (urine). This meta-analysis showed significantly higher Pb levels in all three types of biological material in cases than in controls, suggesting a higher body Pb burden in autistic children. Thus, environmental Pb exposure could be related to the genesis of autism. Since no level of Pb can be considered safe, the data from this study undoubtedly point to the importance of regularly monitoring Pb levels in autistic children.
PB  - MDPI
T2  - Toxics
T1  - Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis
VL  - 11
IS  - 9
SP  - 753
DO  - 10.3390/toxics11090753
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Lakićević, Novak and Pavlović, Slađan Z.",
year = "2023",
abstract = "Environmental pollutants, particularly toxic trace metals with neurotoxic potential, have been related to the genesis of autism. One of these metals that stands out, in particular, is lead (Pb). We conducted an in-depth systematic review and meta-analysis of peer-reviewed studies on Pb levels in biological materials retrieved from autistic children (cases) and neurotypical children (controls) in this work. A systematic review was conducted after the careful selection of published studies according to established criteria to gain a broad insight into the higher or lower levels of Pb in the biological materials of cases and controls, and the findings were then strengthened by a meta-analysis. The meta-analysis included 17 studies (hair), 13 studies (whole blood), and 8 studies (urine). The overall number of controls/cases was 869/915 (hair), 670/755 (whole blood), and 344/373 (urine). This meta-analysis showed significantly higher Pb levels in all three types of biological material in cases than in controls, suggesting a higher body Pb burden in autistic children. Thus, environmental Pb exposure could be related to the genesis of autism. Since no level of Pb can be considered safe, the data from this study undoubtedly point to the importance of regularly monitoring Pb levels in autistic children.",
publisher = "MDPI",
journal = "Toxics",
title = "Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis",
volume = "11",
number = "9",
pages = "753",
doi = "10.3390/toxics11090753"
}

Stojsavljević, A., Lakićević, N.,& Pavlović, S. Z.. (2023). Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis. in Toxics
MDPI., 11(9), 753.
https://doi.org/10.3390/toxics11090753

Stojsavljević A, Lakićević N, Pavlović SZ. Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis. in Toxics. 2023;11(9):753.
doi:10.3390/toxics11090753 .

Stojsavljević, Aleksandar, Lakićević, Novak, Pavlović, Slađan Z., "Does Lead Have a Connection to Autism? A Systematic Review and Meta-Analysis" in Toxics, 11, no. 9 (2023):753,
https://doi.org/10.3390/toxics11090753 . .

TY  - JOUR
AU  - Radaković-Ćosić, Jovana
AU  - Miković, Željko
AU  - Mandić-Rajčević, Stefan
AU  - Sudar-Milovanović, Emina
AU  - Stojsavljević, Aleksandar
AU  - Nikolić, Gorana
AU  - Radojičić, Ognjen
AU  - Perović, Milan
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6194
AB  - Infertility is a major global health issue, affecting approximately 9% of couples worldwide. Its prevalence increased steadily over the preceding decades, paralleling environmental and lifestyle changes. One assisted reproductive technique to overcome infertility is in vitro fertilization (IVF). The IVF procedure consists of several stages, one of which is controlled ovarian stimulation (COS) via various protocols allowing follicular recruitment and maturation in preparation for oocyte retrieval. Follicular fluid (FF) is the microenvironment in which oocytes develop during folliculogenesis, and FF information could be used to assess follicle and oocyte development and maturation stages. Nitric oxide (NO) is a component of FF that is being studied as a predictive factor of follicle maturation and egg quality and as a potential indicator of the success of COS during the IVF process. The hypothesis was that COS affects NO levels in the serum; more specifically, that NO levels in serum after COS correlate with NO levels in FF, based on literature data on the influence of female reproductive hormones on NO metabolism and data on the change in the hormonal milieu affected by COS use. Furthermore, it was hypothesized that NO levels in serum and FF after COS were related to the number of high-quality female reproductive cells obtained during IVF. Assuming that NO levels in serum after COS correlate with NO levels in FF, the central hypothesis of this study is that serum NO levels after COS could be a valuable predictor of oocyte quality and the number of high-quality female reproductive cells achieved by COS. As a result of the hypothesis, measuring NO could be a novel way to improve the efficiency of IVF treatment.
PB  - Elsevier
T2  - Medical Hypotheses
T1  - Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?
VL  - 174
SP  - 111061
DO  - 10.1016/j.mehy.2023.111061
ER  - 

@article{
author = "Radaković-Ćosić, Jovana and Miković, Željko and Mandić-Rajčević, Stefan and Sudar-Milovanović, Emina and Stojsavljević, Aleksandar and Nikolić, Gorana and Radojičić, Ognjen and Perović, Milan",
year = "2023",
abstract = "Infertility is a major global health issue, affecting approximately 9% of couples worldwide. Its prevalence increased steadily over the preceding decades, paralleling environmental and lifestyle changes. One assisted reproductive technique to overcome infertility is in vitro fertilization (IVF). The IVF procedure consists of several stages, one of which is controlled ovarian stimulation (COS) via various protocols allowing follicular recruitment and maturation in preparation for oocyte retrieval. Follicular fluid (FF) is the microenvironment in which oocytes develop during folliculogenesis, and FF information could be used to assess follicle and oocyte development and maturation stages. Nitric oxide (NO) is a component of FF that is being studied as a predictive factor of follicle maturation and egg quality and as a potential indicator of the success of COS during the IVF process. The hypothesis was that COS affects NO levels in the serum; more specifically, that NO levels in serum after COS correlate with NO levels in FF, based on literature data on the influence of female reproductive hormones on NO metabolism and data on the change in the hormonal milieu affected by COS use. Furthermore, it was hypothesized that NO levels in serum and FF after COS were related to the number of high-quality female reproductive cells obtained during IVF. Assuming that NO levels in serum after COS correlate with NO levels in FF, the central hypothesis of this study is that serum NO levels after COS could be a valuable predictor of oocyte quality and the number of high-quality female reproductive cells achieved by COS. As a result of the hypothesis, measuring NO could be a novel way to improve the efficiency of IVF treatment.",
publisher = "Elsevier",
journal = "Medical Hypotheses",
title = "Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?",
volume = "174",
pages = "111061",
doi = "10.1016/j.mehy.2023.111061"
}

Radaković-Ćosić, J., Miković, Ž., Mandić-Rajčević, S., Sudar-Milovanović, E., Stojsavljević, A., Nikolić, G., Radojičić, O.,& Perović, M.. (2023). Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?. in Medical Hypotheses
Elsevier., 174, 111061.
https://doi.org/10.1016/j.mehy.2023.111061

Radaković-Ćosić J, Miković Ž, Mandić-Rajčević S, Sudar-Milovanović E, Stojsavljević A, Nikolić G, Radojičić O, Perović M. Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?. in Medical Hypotheses. 2023;174:111061.
doi:10.1016/j.mehy.2023.111061 .

Radaković-Ćosić, Jovana, Miković, Željko, Mandić-Rajčević, Stefan, Sudar-Milovanović, Emina, Stojsavljević, Aleksandar, Nikolić, Gorana, Radojičić, Ognjen, Perović, Milan, "Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?" in Medical Hypotheses, 174 (2023):111061,
https://doi.org/10.1016/j.mehy.2023.111061 . .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Pavlović, Slađan Z.
AU  - Borković-Mitić, Slavica
AU  - Perović, Milan
AU  - Miković, Željko
AU  - Đurđić, Slađana Z.
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2022
UR  - https://www.mdpi.com/journal/ijms
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5522
AB  - With the ever-growing concern for human health and wellbeing, the prenatal period ofdevelopment requires special attention since fetuses can be exposed to various metals through themother. Therefore, this study explored the status of selected toxic (Pb, Cd, Ni, As, Pt, Ce, Rb, Sr, U)and essential trace metals (Mn, Co, Cu, Zn, Se) in the umbilical cord (UC) sera, maternal sera, andplacental tissue samples of 92 healthy women with normal pregnancies. A further aim focuses on thepotential transplacental transfer of these trace metals. Based on the obtained levels of investigatedelements in clinical samples, it was observed that all of the trace metals cross the placental barrierand reach the fetus. Furthermore, statistical analysis revealed significant differences in levels oftoxic Ni, As, Cd, U, Sr, Rb, and essential Mn, Cu, and Zn between all three types of analyzed clinicalsamples. Correlation analysis highlighted As to be an element with levels that differed significantlybetween all tested samples. Principal component analysis (PCA) was used to enhance these findings.PCA demonstrated that Cd, Mn, Zn, Rb, Ce, U, and Sr were the most influential trace metals indistinguishing placenta from maternal and UC serum samples. As, Co, and Cu were responsible forthe clustering of maternal serum samples, and PCA demonstrated that the Pt level in UC sera wasresponsible for the clustering of these samples. Overall, the findings of this study could contribute toa better understanding of transplacental transfer of these trace metals, and shed a light on overalllevels of metal exposure in the population of healthy pregnant women and their fetuses.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy
VL  - 23
IS  - 15
SP  - 8078
DO  - 10.3390/ijms23158078
ER  - 

@article{
author = "Jagodić, Jovana and Pavlović, Slađan Z. and Borković-Mitić, Slavica and Perović, Milan and Miković, Željko and Đurđić, Slađana Z. and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2022",
abstract = "With the ever-growing concern for human health and wellbeing, the prenatal period ofdevelopment requires special attention since fetuses can be exposed to various metals through themother. Therefore, this study explored the status of selected toxic (Pb, Cd, Ni, As, Pt, Ce, Rb, Sr, U)and essential trace metals (Mn, Co, Cu, Zn, Se) in the umbilical cord (UC) sera, maternal sera, andplacental tissue samples of 92 healthy women with normal pregnancies. A further aim focuses on thepotential transplacental transfer of these trace metals. Based on the obtained levels of investigatedelements in clinical samples, it was observed that all of the trace metals cross the placental barrierand reach the fetus. Furthermore, statistical analysis revealed significant differences in levels oftoxic Ni, As, Cd, U, Sr, Rb, and essential Mn, Cu, and Zn between all three types of analyzed clinicalsamples. Correlation analysis highlighted As to be an element with levels that differed significantlybetween all tested samples. Principal component analysis (PCA) was used to enhance these findings.PCA demonstrated that Cd, Mn, Zn, Rb, Ce, U, and Sr were the most influential trace metals indistinguishing placenta from maternal and UC serum samples. As, Co, and Cu were responsible forthe clustering of maternal serum samples, and PCA demonstrated that the Pt level in UC sera wasresponsible for the clustering of these samples. Overall, the findings of this study could contribute toa better understanding of transplacental transfer of these trace metals, and shed a light on overalllevels of metal exposure in the population of healthy pregnant women and their fetuses.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy",
volume = "23",
number = "15",
pages = "8078",
doi = "10.3390/ijms23158078"
}

Jagodić, J., Pavlović, S. Z., Borković-Mitić, S., Perović, M., Miković, Ž., Đurđić, S. Z., Manojlović, D. D.,& Stojsavljević, A.. (2022). Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy. in International Journal of Molecular Sciences
MDPI., 23(15), 8078.
https://doi.org/10.3390/ijms23158078

Jagodić J, Pavlović SZ, Borković-Mitić S, Perović M, Miković Ž, Đurđić SZ, Manojlović DD, Stojsavljević A. Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy. in International Journal of Molecular Sciences. 2022;23(15):8078.
doi:10.3390/ijms23158078 .

Jagodić, Jovana, Pavlović, Slađan Z., Borković-Mitić, Slavica, Perović, Milan, Miković, Željko, Đurđić, Slađana Z., Manojlović, Dragan D., Stojsavljević, Aleksandar, "Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy" in International Journal of Molecular Sciences, 23, no. 15 (2022):8078,
https://doi.org/10.3390/ijms23158078 . .

TY  - JOUR
AU  - Mitić, Bojan M.
AU  - Borković-Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Stojanović, Dalibor
AU  - Pavlović, Slađan Z.
AU  - Vasiljević, Ljubica
AU  - Ristić, Nataša
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5668
AB  - Three centipede species (Clinopodes flavidus, Cryptops anomalans and Eupolybothrus transsylvanicus) were used
as bioindicators of trace metal and metalloid pollution in Belgrade, Serbia. The concentrations of 13 elements (the metals
Mn, Co, Ni, Cu, Zn, Rb, Sr, Cd, Tl, Pb and U and metalloids As, Se) in whole animals and soil were measured by inductively
coupled plasma mass spectrometry (ICP-MS). Differences in the concentrations of some elements in the analyzed species
were observed, both in response to the sites and between species. In most cases, the trace element concentrations were
higher in centipedes from a polluted site (an industrial area near a busy street with heavy traffic) but C. anomalans and E.
transsylvanicus had higher Mn concentrations at an unpolluted site (a deciduous woodland on Mt. Avala). C. flavidus was
a good bioindicator for detecting differences between Zn, Se and Cd. C. flavidus and C. anomalans were more efficient in
accumulating Zn than E. transsylvanicus. It appears that C. anomalans poorly accumulated Cd, unlike C. flavidus and E.
transsylvanicus, which accumulated Cd according to the high bioaccumulation factor (BAF) values. We conclude that the
centipedes C. flavidus, C. anomalans and E. transsylvanicus can be used as suitable bioindicators of trace element exposure.
Their ability to accumulate trace elements was different and depends on their physiology and lifestyle as well as the route
of exposure.
PB  - Belgrade : Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Metal and metalloid bioaccumulation in three centipedes (Chilopoda)
VL  - 74
IS  - 3
SP  - 207
EP  - 215
DO  - 10.2298/ABS220514019M
ER  - 

@article{
author = "Mitić, Bojan M. and Borković-Mitić, Slavica and Stojsavljević, Aleksandar and Stojanović, Dalibor and Pavlović, Slađan Z. and Vasiljević, Ljubica and Ristić, Nataša",
year = "2022",
abstract = "Three centipede species (Clinopodes flavidus, Cryptops anomalans and Eupolybothrus transsylvanicus) were used
as bioindicators of trace metal and metalloid pollution in Belgrade, Serbia. The concentrations of 13 elements (the metals
Mn, Co, Ni, Cu, Zn, Rb, Sr, Cd, Tl, Pb and U and metalloids As, Se) in whole animals and soil were measured by inductively
coupled plasma mass spectrometry (ICP-MS). Differences in the concentrations of some elements in the analyzed species
were observed, both in response to the sites and between species. In most cases, the trace element concentrations were
higher in centipedes from a polluted site (an industrial area near a busy street with heavy traffic) but C. anomalans and E.
transsylvanicus had higher Mn concentrations at an unpolluted site (a deciduous woodland on Mt. Avala). C. flavidus was
a good bioindicator for detecting differences between Zn, Se and Cd. C. flavidus and C. anomalans were more efficient in
accumulating Zn than E. transsylvanicus. It appears that C. anomalans poorly accumulated Cd, unlike C. flavidus and E.
transsylvanicus, which accumulated Cd according to the high bioaccumulation factor (BAF) values. We conclude that the
centipedes C. flavidus, C. anomalans and E. transsylvanicus can be used as suitable bioindicators of trace element exposure.
Their ability to accumulate trace elements was different and depends on their physiology and lifestyle as well as the route
of exposure.",
publisher = "Belgrade : Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Metal and metalloid bioaccumulation in three centipedes (Chilopoda)",
volume = "74",
number = "3",
pages = "207-215",
doi = "10.2298/ABS220514019M"
}

Mitić, B. M., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S. Z., Vasiljević, L.,& Ristić, N.. (2022). Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences
Belgrade : Serbian Biological Society., 74(3), 207-215.
https://doi.org/10.2298/ABS220514019M

Mitić BM, Borković-Mitić S, Stojsavljević A, Stojanović D, Pavlović SZ, Vasiljević L, Ristić N. Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences. 2022;74(3):207-215.
doi:10.2298/ABS220514019M .

Mitić, Bojan M., Borković-Mitić, Slavica, Stojsavljević, Aleksandar, Stojanović, Dalibor, Pavlović, Slađan Z., Vasiljević, Ljubica, Ristić, Nataša, "Metal and metalloid bioaccumulation in three centipedes (Chilopoda)" in Archives of Biological Sciences, 74, no. 3 (2022):207-215,
https://doi.org/10.2298/ABS220514019M . .

TY  - JOUR
AU  - Manojlović-Stojanoski, Milica
AU  - Borković-Mitić, Slavica
AU  - Nestorović, Nataša
AU  - Ristić, Nataša
AU  - Trifunović, Svetlana
AU  - Stevanović, Magdalena
AU  - Filipović, Nenad
AU  - Stojsavljević, Aleksandar
AU  - Pavlović, Slađan Z.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5681
AB  - The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se0) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se+4) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na2SeO3/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se0) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se0 redox state in comparison to its inorganic sodium selenite form and Se+4 redox state.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta
VL  - 23
IS  - 21
SP  - 13068
DO  - 10.3390/ijms232113068
ER  - 

@article{
author = "Manojlović-Stojanoski, Milica and Borković-Mitić, Slavica and Nestorović, Nataša and Ristić, Nataša and Trifunović, Svetlana and Stevanović, Magdalena and Filipović, Nenad and Stojsavljević, Aleksandar and Pavlović, Slađan Z.",
year = "2022",
abstract = "The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se0) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se+4) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na2SeO3/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se0) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se0 redox state in comparison to its inorganic sodium selenite form and Se+4 redox state.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta",
volume = "23",
number = "21",
pages = "13068",
doi = "10.3390/ijms232113068"
}

Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A.,& Pavlović, S. Z.. (2022). The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. in International Journal of Molecular Sciences
MDPI., 23(21), 13068.
https://doi.org/10.3390/ijms232113068

Manojlović-Stojanoski M, Borković-Mitić S, Nestorović N, Ristić N, Trifunović S, Stevanović M, Filipović N, Stojsavljević A, Pavlović SZ. The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. in International Journal of Molecular Sciences. 2022;23(21):13068.
doi:10.3390/ijms232113068 .

Manojlović-Stojanoski, Milica, Borković-Mitić, Slavica, Nestorović, Nataša, Ristić, Nataša, Trifunović, Svetlana, Stevanović, Magdalena, Filipović, Nenad, Stojsavljević, Aleksandar, Pavlović, Slađan Z., "The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta" in International Journal of Molecular Sciences, 23, no. 21 (2022):13068,
https://doi.org/10.3390/ijms232113068 . .

TY  - DATA
AU  - Mitić, Bojan M.
AU  - Borković-Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Stojanović, Dalibor
AU  - Pavlović, Slađan Z.
AU  - Vasiljević, Ljubica
AU  - Ristić, Nataša
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5673
AB  - Three centipede species (Clinopodes flavidus, Cryptops anomalans and Eupolybothrus transsylvanicus) were usedas bioindicators of trace metal and metalloid pollution in Belgrade, Serbia. The concentrations of 13 elements (the metalsMn, Co, Ni, Cu, Zn, Rb, Sr, Cd, Tl, Pb and U and metalloids As, Se) in whole animals and soil were measured by inductivelycoupled plasma mass spectrometry (ICP-MS). Differences in the concentrations of some elements in the analyzed specieswere observed, both in response to the sites and between species. In most cases, the trace element concentrations werehigher in centipedes from a polluted site (an industrial area near a busy street with heavy traffic) but C. anomalans and E.transsylvanicus had higher Mn concentrations at an unpolluted site (a deciduous woodland on Mt. Avala). C. flavidus wasa good bioindicator for detecting differences between Zn, Se and Cd. C. flavidus and C. anomalans were more efficient inaccumulating Zn than E. transsylvanicus. It appears that C. anomalans poorly accumulated Cd, unlike C. flavidus and E.transsylvanicus, which accumulated Cd according to the high bioaccumulation factor (BAF) values. We conclude that thecentipedes C. flavidus, C. anomalans and E. transsylvanicus can be used as suitable bioindicators of trace element exposure.Their ability to accumulate trace elements was different and depends on their physiology and lifestyle as well as the routeof exposure.
PB  - Belgrade : Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Supplementary material for: Mitić, B., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S., Vasiljević, L.,& Ristić, N.. (2022). Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences Belgrade : Serbian Biological Society., 74(3), 207-215. https://doi.org/10.2298/ABS220514019M
VL  - 74
IS  - 3
SP  - 207
EP  - 215
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5673
ER  - 

@misc{
author = "Mitić, Bojan M. and Borković-Mitić, Slavica and Stojsavljević, Aleksandar and Stojanović, Dalibor and Pavlović, Slađan Z. and Vasiljević, Ljubica and Ristić, Nataša",
year = "2022",
abstract = "Three centipede species (Clinopodes flavidus, Cryptops anomalans and Eupolybothrus transsylvanicus) were usedas bioindicators of trace metal and metalloid pollution in Belgrade, Serbia. The concentrations of 13 elements (the metalsMn, Co, Ni, Cu, Zn, Rb, Sr, Cd, Tl, Pb and U and metalloids As, Se) in whole animals and soil were measured by inductivelycoupled plasma mass spectrometry (ICP-MS). Differences in the concentrations of some elements in the analyzed specieswere observed, both in response to the sites and between species. In most cases, the trace element concentrations werehigher in centipedes from a polluted site (an industrial area near a busy street with heavy traffic) but C. anomalans and E.transsylvanicus had higher Mn concentrations at an unpolluted site (a deciduous woodland on Mt. Avala). C. flavidus wasa good bioindicator for detecting differences between Zn, Se and Cd. C. flavidus and C. anomalans were more efficient inaccumulating Zn than E. transsylvanicus. It appears that C. anomalans poorly accumulated Cd, unlike C. flavidus and E.transsylvanicus, which accumulated Cd according to the high bioaccumulation factor (BAF) values. We conclude that thecentipedes C. flavidus, C. anomalans and E. transsylvanicus can be used as suitable bioindicators of trace element exposure.Their ability to accumulate trace elements was different and depends on their physiology and lifestyle as well as the routeof exposure.",
publisher = "Belgrade : Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Supplementary material for: Mitić, B., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S., Vasiljević, L.,& Ristić, N.. (2022). Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences Belgrade : Serbian Biological Society., 74(3), 207-215. https://doi.org/10.2298/ABS220514019M",
volume = "74",
number = "3",
pages = "207-215",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5673"
}

Mitić, B. M., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S. Z., Vasiljević, L.,& Ristić, N.. (2022). Supplementary material for: Mitić, B., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S., Vasiljević, L.,& Ristić, N.. (2022). Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences Belgrade : Serbian Biological Society., 74(3), 207-215. https://doi.org/10.2298/ABS220514019M. in Archives of Biological Sciences
Belgrade : Serbian Biological Society., 74(3), 207-215.
https://hdl.handle.net/21.15107/rcub_cherry_5673

Mitić BM, Borković-Mitić S, Stojsavljević A, Stojanović D, Pavlović SZ, Vasiljević L, Ristić N. Supplementary material for: Mitić, B., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S., Vasiljević, L.,& Ristić, N.. (2022). Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences Belgrade : Serbian Biological Society., 74(3), 207-215. https://doi.org/10.2298/ABS220514019M. in Archives of Biological Sciences. 2022;74(3):207-215.
https://hdl.handle.net/21.15107/rcub_cherry_5673 .

Mitić, Bojan M., Borković-Mitić, Slavica, Stojsavljević, Aleksandar, Stojanović, Dalibor, Pavlović, Slađan Z., Vasiljević, Ljubica, Ristić, Nataša, "Supplementary material for: Mitić, B., Borković-Mitić, S., Stojsavljević, A., Stojanović, D., Pavlović, S., Vasiljević, L.,& Ristić, N.. (2022). Metal and metalloid bioaccumulation in three centipedes (Chilopoda). in Archives of Biological Sciences Belgrade : Serbian Biological Society., 74(3), 207-215. https://doi.org/10.2298/ABS220514019M" in Archives of Biological Sciences, 74, no. 3 (2022):207-215,
https://hdl.handle.net/21.15107/rcub_cherry_5673 .

TY  - DATA
AU  - Manojlović-Stojanoski, Milica
AU  - Borković-Mitić, Slavica
AU  - Nestorović, Nataša
AU  - Ristić, Nataša
AU  - Trifunović, Svetlana
AU  - Stevanović, Magdalena
AU  - Filipović, Nenad
AU  - Stojsavljević, Aleksandar
AU  - Pavlović, Slađan Z.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5705
AB  - The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se0) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se+4) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na2SeO3/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se0) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se0 redox state in comparison to its inorganic sodium selenite form and Se+4 redox state.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Supplementary material for: Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A., & Pavlović, S. (2022). The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. International Journal of Molecular Sciences, 23(21), 13068. https://doi.org/10.3390/ijms232113068
VL  - 23
IS  - 21
SP  - 13068
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5705
ER  - 

@misc{
author = "Manojlović-Stojanoski, Milica and Borković-Mitić, Slavica and Nestorović, Nataša and Ristić, Nataša and Trifunović, Svetlana and Stevanović, Magdalena and Filipović, Nenad and Stojsavljević, Aleksandar and Pavlović, Slađan Z.",
year = "2022",
abstract = "The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se0) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se+4) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na2SeO3/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se0) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se0 redox state in comparison to its inorganic sodium selenite form and Se+4 redox state.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Supplementary material for: Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A., & Pavlović, S. (2022). The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. International Journal of Molecular Sciences, 23(21), 13068. https://doi.org/10.3390/ijms232113068",
volume = "23",
number = "21",
pages = "13068",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5705"
}

Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A.,& Pavlović, S. Z.. (2022). Supplementary material for: Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A., & Pavlović, S. (2022). The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. International Journal of Molecular Sciences, 23(21), 13068. https://doi.org/10.3390/ijms232113068. in International Journal of Molecular Sciences
MDPI., 23(21), 13068.
https://hdl.handle.net/21.15107/rcub_cherry_5705

Manojlović-Stojanoski M, Borković-Mitić S, Nestorović N, Ristić N, Trifunović S, Stevanović M, Filipović N, Stojsavljević A, Pavlović SZ. Supplementary material for: Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A., & Pavlović, S. (2022). The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. International Journal of Molecular Sciences, 23(21), 13068. https://doi.org/10.3390/ijms232113068. in International Journal of Molecular Sciences. 2022;23(21):13068.
https://hdl.handle.net/21.15107/rcub_cherry_5705 .

Manojlović-Stojanoski, Milica, Borković-Mitić, Slavica, Nestorović, Nataša, Ristić, Nataša, Trifunović, Svetlana, Stevanović, Magdalena, Filipović, Nenad, Stojsavljević, Aleksandar, Pavlović, Slađan Z., "Supplementary material for: Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Trifunović, S., Stevanović, M., Filipović, N., Stojsavljević, A., & Pavlović, S. (2022). The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta. International Journal of Molecular Sciences, 23(21), 13068. https://doi.org/10.3390/ijms232113068" in International Journal of Molecular Sciences, 23, no. 21 (2022):13068,
https://hdl.handle.net/21.15107/rcub_cherry_5705 .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Zečević, Nebojša
AU  - Mihailović, Mladen
AU  - Jagodić, Jovana
AU  - Đurđić, Slađana Z.
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5628
AB  - Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements
VL  - 74
SP  - 127081
DO  - 10.1016/j.jtemb.2022.127081
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Zečević, Nebojša and Mihailović, Mladen and Jagodić, Jovana and Đurđić, Slađana Z. and Perović, Milan and Manojlović, Dragan D.",
year = "2022",
abstract = "Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements",
volume = "74",
pages = "127081",
doi = "10.1016/j.jtemb.2022.127081"
}

Stojsavljević, A., Zečević, N., Mihailović, M., Jagodić, J., Đurđić, S. Z., Perović, M.,& Manojlović, D. D.. (2022). Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements. in Journal of Trace Elements in Medicine and Biology
Elsevier., 74, 127081.
https://doi.org/10.1016/j.jtemb.2022.127081

Stojsavljević A, Zečević N, Mihailović M, Jagodić J, Đurđić SZ, Perović M, Manojlović DD. Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements. in Journal of Trace Elements in Medicine and Biology. 2022;74:127081.
doi:10.1016/j.jtemb.2022.127081 .

Stojsavljević, Aleksandar, Zečević, Nebojša, Mihailović, Mladen, Jagodić, Jovana, Đurđić, Slađana Z., Perović, Milan, Manojlović, Dragan D., "Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements" in Journal of Trace Elements in Medicine and Biology, 74 (2022):127081,
https://doi.org/10.1016/j.jtemb.2022.127081 . .

TY  - JOUR
AU  - Nešić, Andrijana N.
AU  - Stojsavljević, Aleksandar
AU  - Jagodić, Jovana
AU  - Čavić, Milena
AU  - Stefanović, Aleksandra
AU  - Manojlović, Dragan D.
AU  - Gavrović-Jankulović, Marija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5636
AB  - Background: Although essential trace elements (ETEs) play pivotal roles in life-supporting biochemical processes, their function in innate and adaptive immunity has not been fully elucidated, particularly during immunization. Furthermore, the association between anti-SARS-CoV-2 specific IgG antibodies and ETE levels with vaccine responsiveness has not been investigated. Methods: The present study explored the status of ETEs (Mn, Cu, Zn, and Se) in sera of healthy women before and after vaccination with the anti-SARS-CoV-2 BNT162b2 mRNA vaccine in a follow-up period of six months. The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). Results: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. The purified protein was suitable for producing a sensitive antibody detection assay for human serum and monitored seropositivity, indicating a transient response with peak anti-SARS-CoV-2 IgG levels 2 months after vaccination. In parallel to increasing antibody titers, serum concentrations of Cu, Mn, and Se were not affected by vaccination, and concentrations remained relatively constant at the different sampling times during the 6-month observation period. Total serum Zn concentrations were slightly elevated when compared between the first and last sampling dates. Overall, no consistent effects of vaccination on any of the three trace elements analyzed in our study were observed. Conclusion: Vaccination of adult healthy female volunteers with an mRNA vaccine was not associated with consistent changes in serum trace element concentrations over a six-month observation period.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels
VL  - 74
SP  - 127079
DO  - 10.1016/j.jtemb.2022.127079
ER  - 

@article{
author = "Nešić, Andrijana N. and Stojsavljević, Aleksandar and Jagodić, Jovana and Čavić, Milena and Stefanović, Aleksandra and Manojlović, Dragan D. and Gavrović-Jankulović, Marija",
year = "2022",
abstract = "Background: Although essential trace elements (ETEs) play pivotal roles in life-supporting biochemical processes, their function in innate and adaptive immunity has not been fully elucidated, particularly during immunization. Furthermore, the association between anti-SARS-CoV-2 specific IgG antibodies and ETE levels with vaccine responsiveness has not been investigated. Methods: The present study explored the status of ETEs (Mn, Cu, Zn, and Se) in sera of healthy women before and after vaccination with the anti-SARS-CoV-2 BNT162b2 mRNA vaccine in a follow-up period of six months. The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). Results: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. The purified protein was suitable for producing a sensitive antibody detection assay for human serum and monitored seropositivity, indicating a transient response with peak anti-SARS-CoV-2 IgG levels 2 months after vaccination. In parallel to increasing antibody titers, serum concentrations of Cu, Mn, and Se were not affected by vaccination, and concentrations remained relatively constant at the different sampling times during the 6-month observation period. Total serum Zn concentrations were slightly elevated when compared between the first and last sampling dates. Overall, no consistent effects of vaccination on any of the three trace elements analyzed in our study were observed. Conclusion: Vaccination of adult healthy female volunteers with an mRNA vaccine was not associated with consistent changes in serum trace element concentrations over a six-month observation period.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels",
volume = "74",
pages = "127079",
doi = "10.1016/j.jtemb.2022.127079"
}

Nešić, A. N., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D. D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology
Elsevier., 74, 127079.
https://doi.org/10.1016/j.jtemb.2022.127079

Nešić AN, Stojsavljević A, Jagodić J, Čavić M, Stefanović A, Manojlović DD, Gavrović-Jankulović M. A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology. 2022;74:127079.
doi:10.1016/j.jtemb.2022.127079 .

Nešić, Andrijana N., Stojsavljević, Aleksandar, Jagodić, Jovana, Čavić, Milena, Stefanović, Aleksandra, Manojlović, Dragan D., Gavrović-Jankulović, Marija, "A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels" in Journal of Trace Elements in Medicine and Biology, 74 (2022):127079,
https://doi.org/10.1016/j.jtemb.2022.127079 . .

TY  - DATA
AU  - Nešić, Andrijana N.
AU  - Stojsavljević, Aleksandar
AU  - Jagodić, Jovana
AU  - Čavić, Milena
AU  - Stefanović, Aleksandra
AU  - Manojlović, Dragan D.
AU  - Gavrović-Jankulović, Marija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5658
AB  - Background: Although essential trace elements (ETEs) play pivotal roles in life-supporting biochemical processes, their function in innate and adaptive immunity has not been fully elucidated, particularly during immunization. Furthermore, the association between anti-SARS-CoV-2 specific IgG antibodies and ETE levels with vaccine responsiveness has not been investigated. Methods: The present study explored the status of ETEs (Mn, Cu, Zn, and Se) in sera of healthy women before and after vaccination with the anti-SARS-CoV-2 BNT162b2 mRNA vaccine in a follow-up period of six months. The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). Results: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. The purified protein was suitable for producing a sensitive antibody detection assay for human serum and monitored seropositivity, indicating a transient response with peak anti-SARS-CoV-2 IgG levels 2 months after vaccination. In parallel to increasing antibody titers, serum concentrations of Cu, Mn, and Se were not affected by vaccination, and concentrations remained relatively constant at the different sampling times during the 6-month observation period. Total serum Zn concentrations were slightly elevated when compared between the first and last sampling dates. Overall, no consistent effects of vaccination on any of the three trace elements analyzed in our study were observed. Conclusion: Vaccination of adult healthy female volunteers with an mRNA vaccine was not associated with consistent changes in serum trace element concentrations over a six-month observation period.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Supplementary material for: Nešić, A., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology Elsevier., 74, 127079. https://doi.org/10.1016/j.jtemb.2022.127079
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5658
ER  - 

@misc{
author = "Nešić, Andrijana N. and Stojsavljević, Aleksandar and Jagodić, Jovana and Čavić, Milena and Stefanović, Aleksandra and Manojlović, Dragan D. and Gavrović-Jankulović, Marija",
year = "2022",
abstract = "Background: Although essential trace elements (ETEs) play pivotal roles in life-supporting biochemical processes, their function in innate and adaptive immunity has not been fully elucidated, particularly during immunization. Furthermore, the association between anti-SARS-CoV-2 specific IgG antibodies and ETE levels with vaccine responsiveness has not been investigated. Methods: The present study explored the status of ETEs (Mn, Cu, Zn, and Se) in sera of healthy women before and after vaccination with the anti-SARS-CoV-2 BNT162b2 mRNA vaccine in a follow-up period of six months. The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). Results: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. The purified protein was suitable for producing a sensitive antibody detection assay for human serum and monitored seropositivity, indicating a transient response with peak anti-SARS-CoV-2 IgG levels 2 months after vaccination. In parallel to increasing antibody titers, serum concentrations of Cu, Mn, and Se were not affected by vaccination, and concentrations remained relatively constant at the different sampling times during the 6-month observation period. Total serum Zn concentrations were slightly elevated when compared between the first and last sampling dates. Overall, no consistent effects of vaccination on any of the three trace elements analyzed in our study were observed. Conclusion: Vaccination of adult healthy female volunteers with an mRNA vaccine was not associated with consistent changes in serum trace element concentrations over a six-month observation period.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "Supplementary material for: Nešić, A., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology Elsevier., 74, 127079. https://doi.org/10.1016/j.jtemb.2022.127079",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5658"
}

Nešić, A. N., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D. D.,& Gavrović-Jankulović, M.. (2022). Supplementary material for: Nešić, A., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology Elsevier., 74, 127079. https://doi.org/10.1016/j.jtemb.2022.127079. in Journal of Trace Elements in Medicine and Biology
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_5658

Nešić AN, Stojsavljević A, Jagodić J, Čavić M, Stefanović A, Manojlović DD, Gavrović-Jankulović M. Supplementary material for: Nešić, A., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology Elsevier., 74, 127079. https://doi.org/10.1016/j.jtemb.2022.127079. in Journal of Trace Elements in Medicine and Biology. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5658 .

Nešić, Andrijana N., Stojsavljević, Aleksandar, Jagodić, Jovana, Čavić, Milena, Stefanović, Aleksandra, Manojlović, Dragan D., Gavrović-Jankulović, Marija, "Supplementary material for: Nešić, A., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology Elsevier., 74, 127079. https://doi.org/10.1016/j.jtemb.2022.127079" in Journal of Trace Elements in Medicine and Biology (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5658 .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Perović, Milan
AU  - Nešić, Andrijana N.
AU  - Miković, Željko
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - https://link.springer.com/article/10.1007/s11356-022-20205-1
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5116
AB  - According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed pregnant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PB  - SpringerLink
T2  - Environmental Science and Pollution Research
T1  - Levels of non-essential trace metals and their impact on placental health: a review
VL  - 29
SP  - 43662
EP  - 43674
DO  - 10.1007/s11356-022-20205-1
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Perović, Milan and Nešić, Andrijana N. and Miković, Željko and Manojlović, Dragan D.",
year = "2022",
abstract = "According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed pregnant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
publisher = "SpringerLink",
journal = "Environmental Science and Pollution Research",
title = "Levels of non-essential trace metals and their impact on placental health: a review",
volume = "29",
pages = "43662-43674",
doi = "10.1007/s11356-022-20205-1"
}

Stojsavljević, A., Perović, M., Nešić, A. N., Miković, Ž.,& Manojlović, D. D.. (2022). Levels of non-essential trace metals and their impact on placental health: a review. in Environmental Science and Pollution Research
SpringerLink., 29, 43662-43674.
https://doi.org/10.1007/s11356-022-20205-1

Stojsavljević A, Perović M, Nešić AN, Miković Ž, Manojlović DD. Levels of non-essential trace metals and their impact on placental health: a review. in Environmental Science and Pollution Research. 2022;29:43662-43674.
doi:10.1007/s11356-022-20205-1 .

Stojsavljević, Aleksandar, Perović, Milan, Nešić, Andrijana N., Miković, Željko, Manojlović, Dragan D., "Levels of non-essential trace metals and their impact on placental health: a review" in Environmental Science and Pollution Research, 29 (2022):43662-43674,
https://doi.org/10.1007/s11356-022-20205-1 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Jagodić, Jovana
AU  - Miković, Željko
AU  - Jeremić, Ana
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5320
AB  - Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020–2021 and all participants were from Belgrade and two regions (Šumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development.
PB  - SpringerLink
T2  - Exposure and Health
T1  - Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood
VL  - 14
IS  - 3
SP  - 623
EP  - 633
DO  - 10.1007/s12403-021-00441-5
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Jagodić, Jovana and Miković, Željko and Jeremić, Ana and Perović, Milan and Manojlović, Dragan D.",
year = "2022",
abstract = "Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020–2021 and all participants were from Belgrade and two regions (Šumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development.",
publisher = "SpringerLink",
journal = "Exposure and Health",
title = "Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood",
volume = "14",
number = "3",
pages = "623-633",
doi = "10.1007/s12403-021-00441-5"
}

Stojsavljević, A., Rovčanin, M., Jagodić, J., Miković, Ž., Jeremić, A., Perović, M.,& Manojlović, D. D.. (2022). Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood. in Exposure and Health
SpringerLink., 14(3), 623-633.
https://doi.org/10.1007/s12403-021-00441-5

Stojsavljević A, Rovčanin M, Jagodić J, Miković Ž, Jeremić A, Perović M, Manojlović DD. Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood. in Exposure and Health. 2022;14(3):623-633.
doi:10.1007/s12403-021-00441-5 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Jagodić, Jovana, Miković, Željko, Jeremić, Ana, Perović, Milan, Manojlović, Dragan D., "Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood" in Exposure and Health, 14, no. 3 (2022):623-633,
https://doi.org/10.1007/s12403-021-00441-5 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Miković, Željko
AU  - Perović, Milan
AU  - Jeremić, Ana
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4879
AB  - Progressive industrialization in recent decades has contributed to the increase of metal levels in the environment, which has a dangerous impact on human health, primarily pregnant women. In this study, we aimed to compare levels of various elements in maternal and umbilical cord (UC) plasma samples collected from 125 healthy pregnant women, conduct correlation analysis among paired plasma samples, and compare our data with other populations worldwide. The study design included the following elements: essential (Mn, Co, Cu, Zn, Se, Mo), non-essential (Be, Al, Ni, As, Rb, Sr, Cd, Sb, Pb, U), rare earth (La, Pr, Ce, Nd, Sm, Eu, Gd, Dy, Ho, Er), and noble metals (Ru, Rh, Re, Pt). Levels of 30 elements were higher in maternal plasma than in UC plasma samples. However, no disparities at the statistically significant level were found for Be, Zn, Rb, Cd, Ce, and Ho. Correlation analysis among paired plasma samples revealed only positive/synergistic correlations of different strengths between most elements. Compared to other countries across the globe, our participants had considerably lower plasma levels of Zn and higher levels of Co, Ni, and As. This study provides not only a new and deeper comprehension, but also the first insight into the levels, correlation, distribution, and potential transplacental transfer of 30 elements.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood
VL  - 29
SP  - 37375
EP  - 37383
DO  - 10.1007/s11356-021-18190-y
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Miković, Željko and Perović, Milan and Jeremić, Ana and Zečević, Nebojša and Manojlović, Dragan D.",
year = "2022",
abstract = "Progressive industrialization in recent decades has contributed to the increase of metal levels in the environment, which has a dangerous impact on human health, primarily pregnant women. In this study, we aimed to compare levels of various elements in maternal and umbilical cord (UC) plasma samples collected from 125 healthy pregnant women, conduct correlation analysis among paired plasma samples, and compare our data with other populations worldwide. The study design included the following elements: essential (Mn, Co, Cu, Zn, Se, Mo), non-essential (Be, Al, Ni, As, Rb, Sr, Cd, Sb, Pb, U), rare earth (La, Pr, Ce, Nd, Sm, Eu, Gd, Dy, Ho, Er), and noble metals (Ru, Rh, Re, Pt). Levels of 30 elements were higher in maternal plasma than in UC plasma samples. However, no disparities at the statistically significant level were found for Be, Zn, Rb, Cd, Ce, and Ho. Correlation analysis among paired plasma samples revealed only positive/synergistic correlations of different strengths between most elements. Compared to other countries across the globe, our participants had considerably lower plasma levels of Zn and higher levels of Co, Ni, and As. This study provides not only a new and deeper comprehension, but also the first insight into the levels, correlation, distribution, and potential transplacental transfer of 30 elements.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood",
volume = "29",
pages = "37375-37383",
doi = "10.1007/s11356-021-18190-y"
}

Stojsavljević, A., Rovčanin, M., Miković, Ž., Perović, M., Jeremić, A., Zečević, N.,& Manojlović, D. D.. (2022). Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood. in Environmental Science and Pollution Research
Springer., 29, 37375-37383.
https://doi.org/10.1007/s11356-021-18190-y

Stojsavljević A, Rovčanin M, Miković Ž, Perović M, Jeremić A, Zečević N, Manojlović DD. Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood. in Environmental Science and Pollution Research. 2022;29:37375-37383.
doi:10.1007/s11356-021-18190-y .

Stojsavljević, Aleksandar, Rovčanin, Marija, Miković, Željko, Perović, Milan, Jeremić, Ana, Zečević, Nebojša, Manojlović, Dragan D., "Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood" in Environmental Science and Pollution Research, 29 (2022):37375-37383,
https://doi.org/10.1007/s11356-021-18190-y . .

TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Miković, Željko
AU  - Perović, Milan
AU  - Jeremić, Ana
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4880
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4880
ER  - 

@misc{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Miković, Željko and Perović, Milan and Jeremić, Ana and Zečević, Nebojša and Manojlović, Dragan D.",
year = "2022",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4880"
}

Stojsavljević, A., Rovčanin, M., Miković, Ž., Perović, M., Jeremić, A., Zečević, N.,& Manojlović, D. D.. (2022). Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.. in Environmental Science and Pollution Research
Springer..
https://hdl.handle.net/21.15107/rcub_cherry_4880

Stojsavljević A, Rovčanin M, Miković Ž, Perović M, Jeremić A, Zečević N, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.. in Environmental Science and Pollution Research. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4880 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Miković, Željko, Perović, Milan, Jeremić, Ana, Zečević, Nebojša, Manojlović, Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y." in Environmental Science and Pollution Research (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4880 .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Paunović, Ivan
AU  - Mihailović, Mladen
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2022
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4737
AB  - Pheochromocytoma (PCC) is an unusual benign adrenal tumor with an unexamined status of the elements. This study delivers the first insight into the levels of microelements (Mn, Co, Cu, Zn, As, Se, Th), toxic elements (Cd, Pb, U), and macroelements (Na, K, Mg, Ca) in both adrenal tissue and whole blood samples collected from PCC patients. The results were strengthened by comparing recorded findings with the patients’ healthy adrenal tissue (HAT) and with whole blood samples from the healthy individuals. PCCs had significantly higher levels of Zn, Se, Na, K, and Mg and lower levels of Mn, Co, Pb, and As than that of HATs. Compared to healthy blood samples, the patients’ blood exhibited considerably higher levels of Na, K, and Ca but significantly lower levels of Mn, Cu, Zn, Se, and Mg. Females had significantly higher levels of essential Se and toxic Pb and Cd in their PCC tissue samples compared to males. PCC tissue levels of Mn and Cu were significantly elevated in smokers over levels in nonsmokers and in PCC patients with tumor sizes below 5 cm compared to PCC diameters above 5 cm. The data presented in this study provide a new insight into the pathophysiology of PCC. Thus, recorded elements should be considered as initiators/modifiers of PCC and potential inductors of malignant transformation. The findings of this research deepen scientific understanding of this rare adrenal disease, which, in turn, could highlight the pathogenesis of PCC.
PB  - Springer
T2  - Biological Trace Element Research
T1  - Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level
VL  - 200
IS  - 8
SP  - 3482
EP  - 3490
DO  - 10.1007/s12011-021-02945-2
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Paunović, Ivan and Mihailović, Mladen and Zečević, Nebojša and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2022",
abstract = "Pheochromocytoma (PCC) is an unusual benign adrenal tumor with an unexamined status of the elements. This study delivers the first insight into the levels of microelements (Mn, Co, Cu, Zn, As, Se, Th), toxic elements (Cd, Pb, U), and macroelements (Na, K, Mg, Ca) in both adrenal tissue and whole blood samples collected from PCC patients. The results were strengthened by comparing recorded findings with the patients’ healthy adrenal tissue (HAT) and with whole blood samples from the healthy individuals. PCCs had significantly higher levels of Zn, Se, Na, K, and Mg and lower levels of Mn, Co, Pb, and As than that of HATs. Compared to healthy blood samples, the patients’ blood exhibited considerably higher levels of Na, K, and Ca but significantly lower levels of Mn, Cu, Zn, Se, and Mg. Females had significantly higher levels of essential Se and toxic Pb and Cd in their PCC tissue samples compared to males. PCC tissue levels of Mn and Cu were significantly elevated in smokers over levels in nonsmokers and in PCC patients with tumor sizes below 5 cm compared to PCC diameters above 5 cm. The data presented in this study provide a new insight into the pathophysiology of PCC. Thus, recorded elements should be considered as initiators/modifiers of PCC and potential inductors of malignant transformation. The findings of this research deepen scientific understanding of this rare adrenal disease, which, in turn, could highlight the pathogenesis of PCC.",
publisher = "Springer",
journal = "Biological Trace Element Research",
title = "Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level",
volume = "200",
number = "8",
pages = "3482-3490",
doi = "10.1007/s12011-021-02945-2"
}

Jagodić, J., Rovčanin, B., Paunović, I., Mihailović, M., Zečević, N., Manojlović, D. D.,& Stojsavljević, A.. (2022). Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level. in Biological Trace Element Research
Springer., 200(8), 3482-3490.
https://doi.org/10.1007/s12011-021-02945-2

Jagodić J, Rovčanin B, Paunović I, Mihailović M, Zečević N, Manojlović DD, Stojsavljević A. Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level. in Biological Trace Element Research. 2022;200(8):3482-3490.
doi:10.1007/s12011-021-02945-2 .

Jagodić, Jovana, Rovčanin, Branislav, Paunović, Ivan, Mihailović, Mladen, Zečević, Nebojša, Manojlović, Dragan D., Stojsavljević, Aleksandar, "Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level" in Biological Trace Element Research, 200, no. 8 (2022):3482-3490,
https://doi.org/10.1007/s12011-021-02945-2 . .

TY  - JOUR
AU  - Borković-Mitić, Slavica S.
AU  - Stojsavljević, Aleksandar
AU  - Vjotić, Ljiljana
AU  - Matić, Siniša
AU  - Mitić, Bojan M.
AU  - Manojlović, Dragan D.
AU  - Pavlović, Slađan Z.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4820
AB  - There are only a few reports examining the impact of oxidative stress in patients with benign andmalignant brain tumors. In this study we investigated whether there are changes in antioxidantsystem (AOS) parameters and key trace elements between control, benign and malignant braintissues. The study also aimed to examine correlations between the analyzed parameters. The studyenrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The resultswere compared with control tissue (CT) without tumor infiltration collected from patients with BT.The following antioxidant parameters were determined: activities of total, manganese‑containing,and copper/zinc‑containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities ofcatalase, glutathione peroxidase, glutathione S‑transferase, glutathione reductase and acetylcholineesterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn),copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOSparameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changesin AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and highGST activities were significant for distinguishing between MT and CT. Malignant tissue was alsocharacterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysisclearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BTand MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in theMT group. The results of this study reveal differences between the AOS parameters and the essentialtrace elements between the analyzed groups. The observed dysregulations show that oxidative stresscould have an important role in disrupting brain homeostasis and its presence in the pathogenesis ofbenign and malignant brain tumors.
PB  - Springer
T2  - Scientifc Reports
T1  - Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues
VL  - 11
SP  - 14776
DO  - 10.1038/s41598-021-94302-5
ER  - 

@article{
author = "Borković-Mitić, Slavica S. and Stojsavljević, Aleksandar and Vjotić, Ljiljana and Matić, Siniša and Mitić, Bojan M. and Manojlović, Dragan D. and Pavlović, Slađan Z.",
year = "2021",
abstract = "There are only a few reports examining the impact of oxidative stress in patients with benign andmalignant brain tumors. In this study we investigated whether there are changes in antioxidantsystem (AOS) parameters and key trace elements between control, benign and malignant braintissues. The study also aimed to examine correlations between the analyzed parameters. The studyenrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The resultswere compared with control tissue (CT) without tumor infiltration collected from patients with BT.The following antioxidant parameters were determined: activities of total, manganese‑containing,and copper/zinc‑containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities ofcatalase, glutathione peroxidase, glutathione S‑transferase, glutathione reductase and acetylcholineesterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn),copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOSparameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changesin AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and highGST activities were significant for distinguishing between MT and CT. Malignant tissue was alsocharacterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysisclearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BTand MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in theMT group. The results of this study reveal differences between the AOS parameters and the essentialtrace elements between the analyzed groups. The observed dysregulations show that oxidative stresscould have an important role in disrupting brain homeostasis and its presence in the pathogenesis ofbenign and malignant brain tumors.",
publisher = "Springer",
journal = "Scientifc Reports",
title = "Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues",
volume = "11",
pages = "14776",
doi = "10.1038/s41598-021-94302-5"
}

Borković-Mitić, S. S., Stojsavljević, A., Vjotić, L., Matić, S., Mitić, B. M., Manojlović, D. D.,& Pavlović, S. Z.. (2021). Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. in Scientifc Reports
Springer., 11, 14776.
https://doi.org/10.1038/s41598-021-94302-5

Borković-Mitić SS, Stojsavljević A, Vjotić L, Matić S, Mitić BM, Manojlović DD, Pavlović SZ. Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. in Scientifc Reports. 2021;11:14776.
doi:10.1038/s41598-021-94302-5 .

Borković-Mitić, Slavica S., Stojsavljević, Aleksandar, Vjotić, Ljiljana, Matić, Siniša, Mitić, Bojan M., Manojlović, Dragan D., Pavlović, Slađan Z., "Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues" in Scientifc Reports, 11 (2021):14776,
https://doi.org/10.1038/s41598-021-94302-5 . .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Borković-Mitić, Slavica S.
AU  - Vujotić, Ljiljana
AU  - Avdin, Viacheslav V.
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4794
AB  - Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues
VL  - 28
SP  - 47439
EP  - 47446
DO  - 10.1007/s11356-021-14013-2
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Borković-Mitić, Slavica S. and Vujotić, Ljiljana and Avdin, Viacheslav V. and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2021",
abstract = "Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues",
volume = "28",
pages = "47439-47446",
doi = "10.1007/s11356-021-14013-2"
}

Jagodić, J., Rovčanin, B., Borković-Mitić, S. S., Vujotić, L., Avdin, V. V., Manojlović, D. D.,& Stojsavljević, A.. (2021). Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues. in Environmental Science and Pollution Research
Springer., 28, 47439-47446.
https://doi.org/10.1007/s11356-021-14013-2

Jagodić J, Rovčanin B, Borković-Mitić SS, Vujotić L, Avdin VV, Manojlović DD, Stojsavljević A. Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues. in Environmental Science and Pollution Research. 2021;28:47439-47446.
doi:10.1007/s11356-021-14013-2 .

Jagodić, Jovana, Rovčanin, Branislav, Borković-Mitić, Slavica S., Vujotić, Ljiljana, Avdin, Viacheslav V., Manojlović, Dragan D., Stojsavljević, Aleksandar, "Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues" in Environmental Science and Pollution Research, 28 (2021):47439-47446,
https://doi.org/10.1007/s11356-021-14013-2 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
AU  - Jagodić, Jovana
AU  - Krstić, Đurđa D.
AU  - Paunović, Ivan
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
PY  - 2021
UR  - https://doi.org/10.1007/s12011-020-02542-9
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4780
AB  - Modest progress has been made in understanding the role of trace elements as endocrine disruptors. The aim of this study was to examine whether there is a change in the content of trace elements in thyroid disease, as well as whether the ratio of elements could be considered a blood marker for thyroid disease. In addition, this study examined the influence of biological and clinical/pathological parameters on the elemental profile. Blood samples from patients diagnosed with multinodular goiter (MNG), thyroid adenoma (TA), and thyroid cancer (TC) were examined and compared with control samples using chemometric analysis. The concentrations of essential (Mn, Co, Cu, Zn, Se) and toxic elements (Ni, As, Cd, Pb, U) were determined by ICP-MS. This study showed for the first time that the content of Mn, Co, Ni, Cu, Zn, Se, and Pb in pathological blood samples was significantly lower compared to the control, while opposite results were obtained for As, Cd, and U. Based on the classification model, the most important trace metals for discrimination of MNG and TC from the control group (CG) were Co and Zn, while Co, Zn, and Mn influenced the distinction of CG from TA. Moreover, it was found that Cu/Zn and U/Se ratios had significantly increased values in pathological blood samples leading to the possibility of establishing new circulating screening markers. These findings can represent significant translational information since these diseases are widespread and the diagnostic procedure is still difficult in many cases.
PB  - Springer
T2  - Biological Trace Element Research
T1  - Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer
VL  - 199
IS  - 11
SP  - 4055
EP  - 4065
DO  - 10.1007/s12011-020-02542-9
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Jagodić, Jovana and Krstić, Đurđa D. and Paunović, Ivan and Gavrović-Jankulović, Marija and Manojlović, Dragan D.",
year = "2021",
abstract = "Modest progress has been made in understanding the role of trace elements as endocrine disruptors. The aim of this study was to examine whether there is a change in the content of trace elements in thyroid disease, as well as whether the ratio of elements could be considered a blood marker for thyroid disease. In addition, this study examined the influence of biological and clinical/pathological parameters on the elemental profile. Blood samples from patients diagnosed with multinodular goiter (MNG), thyroid adenoma (TA), and thyroid cancer (TC) were examined and compared with control samples using chemometric analysis. The concentrations of essential (Mn, Co, Cu, Zn, Se) and toxic elements (Ni, As, Cd, Pb, U) were determined by ICP-MS. This study showed for the first time that the content of Mn, Co, Ni, Cu, Zn, Se, and Pb in pathological blood samples was significantly lower compared to the control, while opposite results were obtained for As, Cd, and U. Based on the classification model, the most important trace metals for discrimination of MNG and TC from the control group (CG) were Co and Zn, while Co, Zn, and Mn influenced the distinction of CG from TA. Moreover, it was found that Cu/Zn and U/Se ratios had significantly increased values in pathological blood samples leading to the possibility of establishing new circulating screening markers. These findings can represent significant translational information since these diseases are widespread and the diagnostic procedure is still difficult in many cases.",
publisher = "Springer",
journal = "Biological Trace Element Research",
title = "Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer",
volume = "199",
number = "11",
pages = "4055-4065",
doi = "10.1007/s12011-020-02542-9"
}

Stojsavljević, A., Rovčanin, B., Jagodić, J., Krstić, Đ. D., Paunović, I., Gavrović-Jankulović, M.,& Manojlović, D. D.. (2021). Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer. in Biological Trace Element Research
Springer., 199(11), 4055-4065.
https://doi.org/10.1007/s12011-020-02542-9

Stojsavljević A, Rovčanin B, Jagodić J, Krstić ĐD, Paunović I, Gavrović-Jankulović M, Manojlović DD. Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer. in Biological Trace Element Research. 2021;199(11):4055-4065.
doi:10.1007/s12011-020-02542-9 .

Stojsavljević, Aleksandar, Rovčanin, Branislav, Jagodić, Jovana, Krstić, Đurđa D., Paunović, Ivan, Gavrović-Jankulović, Marija, Manojlović, Dragan D., "Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer" in Biological Trace Element Research, 199, no. 11 (2021):4055-4065,
https://doi.org/10.1007/s12011-020-02542-9 . .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Paunović, Ivan
AU  - Jovanović, Milan
AU  - Gavrović-Jankulović, Marija
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4787
AB  - Background
The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA).

Methods
The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS).

Results
This is the first study that provided an insight into the elemental status of HATs. It was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition.

Conclusion
For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas
VL  - 63
SP  - 126658
DO  - 10.1016/j.jtemb.2020.126658
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Paunović, Ivan and Jovanović, Milan and Gavrović-Jankulović, Marija and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2021",
abstract = "Background
The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA).

Methods
The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS).

Results
This is the first study that provided an insight into the elemental status of HATs. It was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition.

Conclusion
For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas",
volume = "63",
pages = "126658",
doi = "10.1016/j.jtemb.2020.126658"
}

Jagodić, J., Rovčanin, B., Paunović, I., Jovanović, M., Gavrović-Jankulović, M., Manojlović, D. D.,& Stojsavljević, A.. (2021). The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas. in Journal of Trace Elements in Medicine and Biology
Elsevier., 63, 126658.
https://doi.org/10.1016/j.jtemb.2020.126658

Jagodić J, Rovčanin B, Paunović I, Jovanović M, Gavrović-Jankulović M, Manojlović DD, Stojsavljević A. The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas. in Journal of Trace Elements in Medicine and Biology. 2021;63:126658.
doi:10.1016/j.jtemb.2020.126658 .

Jagodić, Jovana, Rovčanin, Branislav, Paunović, Ivan, Jovanović, Milan, Gavrović-Jankulović, Marija, Manojlović, Dragan D., Stojsavljević, Aleksandar, "The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas" in Journal of Trace Elements in Medicine and Biology, 63 (2021):126658,
https://doi.org/10.1016/j.jtemb.2020.126658 . .

TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Rovčanin, Branislav
AU  - Miković, Željko
AU  - Jeremić, Ana
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4806
PB  - Elsevier
T2  - Chemosphere
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4806
ER  - 

@misc{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Rovčanin, Branislav and Miković, Željko and Jeremić, Ana and Perović, Milan and Manojlović, Dragan D.",
year = "2021",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4806"
}

Stojsavljević, A., Rovčanin, M., Rovčanin, B., Miković, Ž., Jeremić, A., Perović, M.,& Manojlović, D. D.. (2021). Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.. in Chemosphere
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4806

Stojsavljević A, Rovčanin M, Rovčanin B, Miković Ž, Jeremić A, Perović M, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.. in Chemosphere. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4806 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Rovčanin, Branislav, Miković, Željko, Jeremić, Ana, Perović, Milan, Manojlović, Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518." in Chemosphere (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4806 .

TY  - JOUR
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0026265X21002782
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4530
AB  - The elemental composition of control and pathological adrenal tissues remains to be resolved. This study aimed to provide an initial insight into the amounts of micro- (Mn, Co, Cu, Zn, As, Se, Cd, Pb, U) and macroelements (Na, K, Mg, Ca) in healthy adrenal tissue (HAT) and adenomatous adrenal tissue (AAT) samples collected from patients with adrenal adenoma (AA) using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). The results were accompanied by a comparative determination of the same elements in healthy blood (HB) and adenomatous blood (AB) samples. This is the first study that has provided in-depth knowledge of the baseline composition of the clinically important elements of HAT samples. Furthermore, this study showed elementary changes in AA patients. The AATs had significantly higher amounts of Mn, Cu, Zn, Se, Pb, K, and Mg compared to the HATs. The opposite results were obtained for the same elements in the AB samples, indicating that the benign adrenal masses could have the ability to withdraw these elements from circulation. These results were supplemented by principal component analysis (PCA). ICP-based techniques were successfully applied to accurately provide a more comprehensive insight into the clinically important elements in the solid tissue and blood samples. The results of this study are a deep-dive into the likely future of clinical studies. Moreover, target elements should be taken into consideration as novel initiating and/or modifying factors of AA, after further research, this would include the analysis of a larger number of samples and prospective follow-up of the patient’s elemental profile.
PB  - Elsevier
T2  - Microchemical Journal
T1  - Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES
VL  - 165
SP  - 106194
DO  - 10.1016/j.microc.2021.106194
ER  - 

@article{
author = "Jagodić, Jovana and Rovčanin, Branislav and Krstić, Đurđa D. and Paunović, Ivan and Živaljević, Vladan and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2021",
abstract = "The elemental composition of control and pathological adrenal tissues remains to be resolved. This study aimed to provide an initial insight into the amounts of micro- (Mn, Co, Cu, Zn, As, Se, Cd, Pb, U) and macroelements (Na, K, Mg, Ca) in healthy adrenal tissue (HAT) and adenomatous adrenal tissue (AAT) samples collected from patients with adrenal adenoma (AA) using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). The results were accompanied by a comparative determination of the same elements in healthy blood (HB) and adenomatous blood (AB) samples. This is the first study that has provided in-depth knowledge of the baseline composition of the clinically important elements of HAT samples. Furthermore, this study showed elementary changes in AA patients. The AATs had significantly higher amounts of Mn, Cu, Zn, Se, Pb, K, and Mg compared to the HATs. The opposite results were obtained for the same elements in the AB samples, indicating that the benign adrenal masses could have the ability to withdraw these elements from circulation. These results were supplemented by principal component analysis (PCA). ICP-based techniques were successfully applied to accurately provide a more comprehensive insight into the clinically important elements in the solid tissue and blood samples. The results of this study are a deep-dive into the likely future of clinical studies. Moreover, target elements should be taken into consideration as novel initiating and/or modifying factors of AA, after further research, this would include the analysis of a larger number of samples and prospective follow-up of the patient’s elemental profile.",
publisher = "Elsevier",
journal = "Microchemical Journal",
title = "Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES",
volume = "165",
pages = "106194",
doi = "10.1016/j.microc.2021.106194"
}

Jagodić, J., Rovčanin, B., Krstić, Đ. D., Paunović, I., Živaljević, V., Manojlović, D. D.,& Stojsavljević, A.. (2021). Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES. in Microchemical Journal
Elsevier., 165, 106194.
https://doi.org/10.1016/j.microc.2021.106194

Jagodić J, Rovčanin B, Krstić ĐD, Paunović I, Živaljević V, Manojlović DD, Stojsavljević A. Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES. in Microchemical Journal. 2021;165:106194.
doi:10.1016/j.microc.2021.106194 .

Jagodić, Jovana, Rovčanin, Branislav, Krstić, Đurđa D., Paunović, Ivan, Živaljević, Vladan, Manojlović, Dragan D., Stojsavljević, Aleksandar, "Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES" in Microchemical Journal, 165 (2021):106194,
https://doi.org/10.1016/j.microc.2021.106194 . .

TY  - DATA
AU  - Jagodić, Jovana
AU  - Rovčanin, Branislav
AU  - Krstić, Đurđa D.
AU  - Paunović, Ivan
AU  - Živaljević, Vladan
AU  - Manojlović, Dragan D.
AU  - Stojsavljević, Aleksandar
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4531
PB  - Elsevier
T2  - Microchemical Journal
T1  - Supplementary data for the article: Jagodić, J.; Rovčanin, B.; Krstić, Đ.; Paunović, I.; Živaljević, V.; Manojlović, D.; Stojsavljević, A. Elemental Profiling of Adrenal Adenomas in Solid Tissue and Blood Samples by ICP-MS and ICP-OES. Microchemical Journal 2021, 165, 106194. https://doi.org/10.1016/j.microc.2021.106194.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4531
ER  - 

@misc{
author = "Jagodić, Jovana and Rovčanin, Branislav and Krstić, Đurđa D. and Paunović, Ivan and Živaljević, Vladan and Manojlović, Dragan D. and Stojsavljević, Aleksandar",
year = "2021",
publisher = "Elsevier",
journal = "Microchemical Journal",
title = "Supplementary data for the article: Jagodić, J.; Rovčanin, B.; Krstić, Đ.; Paunović, I.; Živaljević, V.; Manojlović, D.; Stojsavljević, A. Elemental Profiling of Adrenal Adenomas in Solid Tissue and Blood Samples by ICP-MS and ICP-OES. Microchemical Journal 2021, 165, 106194. https://doi.org/10.1016/j.microc.2021.106194.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4531"
}

Jagodić, J., Rovčanin, B., Krstić, Đ. D., Paunović, I., Živaljević, V., Manojlović, D. D.,& Stojsavljević, A.. (2021). Supplementary data for the article: Jagodić, J.; Rovčanin, B.; Krstić, Đ.; Paunović, I.; Živaljević, V.; Manojlović, D.; Stojsavljević, A. Elemental Profiling of Adrenal Adenomas in Solid Tissue and Blood Samples by ICP-MS and ICP-OES. Microchemical Journal 2021, 165, 106194. https://doi.org/10.1016/j.microc.2021.106194.. in Microchemical Journal
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4531

Jagodić J, Rovčanin B, Krstić ĐD, Paunović I, Živaljević V, Manojlović DD, Stojsavljević A. Supplementary data for the article: Jagodić, J.; Rovčanin, B.; Krstić, Đ.; Paunović, I.; Živaljević, V.; Manojlović, D.; Stojsavljević, A. Elemental Profiling of Adrenal Adenomas in Solid Tissue and Blood Samples by ICP-MS and ICP-OES. Microchemical Journal 2021, 165, 106194. https://doi.org/10.1016/j.microc.2021.106194.. in Microchemical Journal. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4531 .

Jagodić, Jovana, Rovčanin, Branislav, Krstić, Đurđa D., Paunović, Ivan, Živaljević, Vladan, Manojlović, Dragan D., Stojsavljević, Aleksandar, "Supplementary data for the article: Jagodić, J.; Rovčanin, B.; Krstić, Đ.; Paunović, I.; Živaljević, V.; Manojlović, D.; Stojsavljević, A. Elemental Profiling of Adrenal Adenomas in Solid Tissue and Blood Samples by ICP-MS and ICP-OES. Microchemical Journal 2021, 165, 106194. https://doi.org/10.1016/j.microc.2021.106194." in Microchemical Journal (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4531 .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Rovčanin, Branislav
AU  - Miković, Željko
AU  - Jeremić, Ana
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4805
AB  - Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy.
PB  - Elsevier
T2  - Chemosphere
T1  - Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues
VL  - 285
SP  - 131518
DO  - 10.1016/j.chemosphere.2021.131518
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Rovčanin, Branislav and Miković, Željko and Jeremić, Ana and Perović, Milan and Manojlović, Dragan D.",
year = "2021",
abstract = "Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy.",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues",
volume = "285",
pages = "131518",
doi = "10.1016/j.chemosphere.2021.131518"
}

Stojsavljević, A., Rovčanin, M., Rovčanin, B., Miković, Ž., Jeremić, A., Perović, M.,& Manojlović, D. D.. (2021). Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues. in Chemosphere
Elsevier., 285, 131518.
https://doi.org/10.1016/j.chemosphere.2021.131518

Stojsavljević A, Rovčanin M, Rovčanin B, Miković Ž, Jeremić A, Perović M, Manojlović DD. Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues. in Chemosphere. 2021;285:131518.
doi:10.1016/j.chemosphere.2021.131518 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Rovčanin, Branislav, Miković, Željko, Jeremić, Ana, Perović, Milan, Manojlović, Dragan D., "Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues" in Chemosphere, 285 (2021):131518,
https://doi.org/10.1016/j.chemosphere.2021.131518 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Branislav
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4562
AB  - Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.
PB  - Springer
T2  - Exposure and Health
T1  - Impact of essential and toxic trace metals on thyroid health and cancer: A review
VL  - 13
SP  - 613
EP  - 627
DO  - 10.1007/s12403-021-00406-8
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Branislav",
year = "2021",
abstract = "Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.",
publisher = "Springer",
journal = "Exposure and Health",
title = "Impact of essential and toxic trace metals on thyroid health and cancer: A review",
volume = "13",
pages = "613-627",
doi = "10.1007/s12403-021-00406-8"
}

Stojsavljević, A.,& Rovčanin, B.. (2021). Impact of essential and toxic trace metals on thyroid health and cancer: A review. in Exposure and Health
Springer., 13, 613-627.
https://doi.org/10.1007/s12403-021-00406-8

Stojsavljević A, Rovčanin B. Impact of essential and toxic trace metals on thyroid health and cancer: A review. in Exposure and Health. 2021;13:613-627.
doi:10.1007/s12403-021-00406-8 .

Stojsavljević, Aleksandar, Rovčanin, Branislav, "Impact of essential and toxic trace metals on thyroid health and cancer: A review" in Exposure and Health, 13 (2021):613-627,
https://doi.org/10.1007/s12403-021-00406-8 . .