Vukadinović, Aleksandar

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orcid::0000-0002-9352-8036
  • Vukadinović, Aleksandar (6)
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Author's Bibliography

Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP

Stanković, Dalibor; Ristić, Slavica M.; Vukadinović, Aleksandar; Mirković, Marija D.; Vladimirov, Sandra S.; Milanović, Zorana; Radović, Magdalena; Mijović, Milica; Stanković, Dalibor; Sabo, Tibor; Vranješ-Đurić, Sanja; Janković, Drina

(SAGE PUBLICATIONS LTD, 2019)

TY  - JOUR
AU  - Stanković, Dalibor
AU  - Ristić, Slavica M.
AU  - Vukadinović, Aleksandar
AU  - Mirković, Marija D.
AU  - Vladimirov, Sandra S.
AU  - Milanović, Zorana
AU  - Radović, Magdalena
AU  - Mijović, Milica
AU  - Stanković, Dalibor
AU  - Sabo, Tibor
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2894
AB  - It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD 50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes.
PB  - SAGE PUBLICATIONS LTD
T2  - Human and Experimental Toxicology
T1  - Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP
VL  - 38
IS  - 4
SP  - 466
EP  - 481
DO  - 10.1177/0960327118819047
ER  - 
@article{
author = "Stanković, Dalibor and Ristić, Slavica M. and Vukadinović, Aleksandar and Mirković, Marija D. and Vladimirov, Sandra S. and Milanović, Zorana and Radović, Magdalena and Mijović, Milica and Stanković, Dalibor and Sabo, Tibor and Vranješ-Đurić, Sanja and Janković, Drina",
year = "2019",
abstract = "It was reported that novel O,O′-diethyl-(S, S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl) propanoate dihydrochloride (DE-EDCP) displayed in vitro antiproliferative activity on several human and mouse cancer cell lines, which was comparable to that of the prototypical anticancer drug cisplatin. In order to reveal its toxicity profile, acute and repeated-dose toxicity studies were performed in Naval Medical Research Institute (NMRI) Han mice. The intravenous LD 50 values of DE-EDCP were found to be 95.3 and 101.3 mg/kg body weight in female and male mice, respectively. In the subacute toxicity study, DE-EDCP was administered intravenously at the doses of 15, 25, and 40 mg/kg/day for a period of 28 days. There were no adverse effects on general condition, growth, feed and water consumption, and hematological parameters. There was a significant increase in urea and alanine aminotransferase in female mice and aspartate aminotransferase and alkaline phosphatase in both genders in 40 mg/kg/day dose-treated group. The histopathological changes confined to the liver and kidney, but in other organs were not found. Satellite group revealed that changes in the kidney and liver were less pronounced, suggesting their reversibility. Interactions with DNA could also be of importance for understanding DE-EDCP toxic side effects. Hyperchromic effect obtained with ultraviolet–visible, suggested electrostatic interactions between DE-EDCP and calf thymus DNA. The toxicity testing of DE-EDCP was conducted to predict human outcomes.",
publisher = "SAGE PUBLICATIONS LTD",
journal = "Human and Experimental Toxicology",
title = "Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP",
volume = "38",
number = "4",
pages = "466-481",
doi = "10.1177/0960327118819047"
}
Stanković, D., Ristić, S. M., Vukadinović, A., Mirković, M. D., Vladimirov, S. S., Milanović, Z., Radović, M., Mijović, M., Stanković, D., Sabo, T., Vranješ-Đurić, S.,& Janković, D.. (2019). Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. in Human and Experimental Toxicology
SAGE PUBLICATIONS LTD., 38(4), 466-481.
https://doi.org/10.1177/0960327118819047
Stanković D, Ristić SM, Vukadinović A, Mirković MD, Vladimirov SS, Milanović Z, Radović M, Mijović M, Stanković D, Sabo T, Vranješ-Đurić S, Janković D. Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. in Human and Experimental Toxicology. 2019;38(4):466-481.
doi:10.1177/0960327118819047 .
Stanković, Dalibor, Ristić, Slavica M., Vukadinović, Aleksandar, Mirković, Marija D., Vladimirov, Sandra S., Milanović, Zorana, Radović, Magdalena, Mijović, Milica, Stanković, Dalibor, Sabo, Tibor, Vranješ-Đurić, Sanja, Janković, Drina, "Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP" in Human and Experimental Toxicology, 38, no. 4 (2019):466-481,
https://doi.org/10.1177/0960327118819047 . .
1

Supplementary material for the article: Ognjanović, M.; Stanković, D. M.; Fabián, M.; Vukadinović, A.; Prijović, Ž.; Dojčinović, B.; Antić, B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-Modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone. Electroanalysis 2018, 30 (11), 2620–2627. https://doi.org/10.1002/elan.201800357

Ognjanović, Miloš; Stanković, Dalibor; Fabián, Martin; Vukadinović, Aleksandar; Prijović, Željko; Dojčinović, Biljana P.; Antić, Bratislav

(2018)

TY  - DATA
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor
AU  - Fabián, Martin
AU  - Vukadinović, Aleksandar
AU  - Prijović, Željko
AU  - Dojčinović, Biljana P.
AU  - Antić, Bratislav
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3150
T2  - Electroanalysis
T1  - Supplementary material for the article: Ognjanović, M.; Stanković, D. M.; Fabián, M.; Vukadinović, A.; Prijović, Ž.; Dojčinović, B.;  Antić, B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene  Oxide-Modified Electrode for Sensitive and Simultaneous Determination of Catechol and  Hydroquinone. Electroanalysis 2018, 30 (11), 2620–2627.  https://doi.org/10.1002/elan.201800357
ER  - 
@misc{
author = "Ognjanović, Miloš and Stanković, Dalibor and Fabián, Martin and Vukadinović, Aleksandar and Prijović, Željko and Dojčinović, Biljana P. and Antić, Bratislav",
year = "2018",
journal = "Electroanalysis",
title = "Supplementary material for the article: Ognjanović, M.; Stanković, D. M.; Fabián, M.; Vukadinović, A.; Prijović, Ž.; Dojčinović, B.;  Antić, B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene  Oxide-Modified Electrode for Sensitive and Simultaneous Determination of Catechol and  Hydroquinone. Electroanalysis 2018, 30 (11), 2620–2627.  https://doi.org/10.1002/elan.201800357"
}
Ognjanović, M., Stanković, D., Fabián, M., Vukadinović, A., Prijović, Ž., Dojčinović, B. P.,& Antić, B.. (2018). Supplementary material for the article: Ognjanović, M.; Stanković, D. M.; Fabián, M.; Vukadinović, A.; Prijović, Ž.; Dojčinović, B.;  Antić, B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene  Oxide-Modified Electrode for Sensitive and Simultaneous Determination of Catechol and  Hydroquinone. Electroanalysis 2018, 30 (11), 2620–2627.  https://doi.org/10.1002/elan.201800357. in Electroanalysis.
Ognjanović M, Stanković D, Fabián M, Vukadinović A, Prijović Ž, Dojčinović BP, Antić B. Supplementary material for the article: Ognjanović, M.; Stanković, D. M.; Fabián, M.; Vukadinović, A.; Prijović, Ž.; Dojčinović, B.;  Antić, B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene  Oxide-Modified Electrode for Sensitive and Simultaneous Determination of Catechol and  Hydroquinone. Electroanalysis 2018, 30 (11), 2620–2627.  https://doi.org/10.1002/elan.201800357. in Electroanalysis. 2018;..
Ognjanović, Miloš, Stanković, Dalibor, Fabián, Martin, Vukadinović, Aleksandar, Prijović, Željko, Dojčinović, Biljana P., Antić, Bratislav, "Supplementary material for the article: Ognjanović, M.; Stanković, D. M.; Fabián, M.; Vukadinović, A.; Prijović, Ž.; Dojčinović, B.;  Antić, B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene  Oxide-Modified Electrode for Sensitive and Simultaneous Determination of Catechol and  Hydroquinone. Electroanalysis 2018, 30 (11), 2620–2627.  https://doi.org/10.1002/elan.201800357" in Electroanalysis (2018).

A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone

Ognjanović, Miloš; Stanković, Dalibor; Fabián, Martin; Vukadinović, Aleksandar; Prijović, Željko; Dojčinović, Biljana P.; Antić, Bratislav

(2018)

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor
AU  - Fabián, Martin
AU  - Vukadinović, Aleksandar
AU  - Prijović, Željko
AU  - Dojčinović, Biljana P.
AU  - Antić, Bratislav
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/344
AB  - In this work facile one step synthesis of magnesium ferrite (MgFe2O4) nanoparticles decorated on reduced graphene oxide (MgFe"RGO) using a microwave assisted hydrothermal procedure is reported. The synthesized material was characterized with help of several techniques and applied for the modification of glassy carbon electrode. Such prepared electrode was utilized for successive simultaneous detection of structurally similar compounds, 1,2- and 1,4-dihydroxibenzenes (catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. It was found that oxidation current increases linearly with the concentrations of both investigated compounds. Detection limits for both species are ≤0.31 μM. The best analytical response in the presence of both CC and HQ, taking into account peak shape and peak current, was obtained at pH 5.6 utilizing acetate buffer solution. The often-presented species in the surface waters as well as gallic acid and caffeine do not interfere with determination of CC and HQ, while ascorbic acid shows high interference. The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
T2  - Electroanalysis
T1  - A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone
DO  - 10.1002/elan.201800357
UR  - Kon_1315
ER  - 
@article{
author = "Ognjanović, Miloš and Stanković, Dalibor and Fabián, Martin and Vukadinović, Aleksandar and Prijović, Željko and Dojčinović, Biljana P. and Antić, Bratislav",
year = "2018",
abstract = "In this work facile one step synthesis of magnesium ferrite (MgFe2O4) nanoparticles decorated on reduced graphene oxide (MgFe"RGO) using a microwave assisted hydrothermal procedure is reported. The synthesized material was characterized with help of several techniques and applied for the modification of glassy carbon electrode. Such prepared electrode was utilized for successive simultaneous detection of structurally similar compounds, 1,2- and 1,4-dihydroxibenzenes (catechol (CC) and hydroquinone (HQ)), using differential pulse voltammetry technique. It was found that oxidation current increases linearly with the concentrations of both investigated compounds. Detection limits for both species are ≤0.31 μM. The best analytical response in the presence of both CC and HQ, taking into account peak shape and peak current, was obtained at pH 5.6 utilizing acetate buffer solution. The often-presented species in the surface waters as well as gallic acid and caffeine do not interfere with determination of CC and HQ, while ascorbic acid shows high interference. The method is successfully applied for detection of catechol and hydroquinone in real samples analyses. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
journal = "Electroanalysis",
title = "A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone",
doi = "10.1002/elan.201800357",
url = "Kon_1315"
}
Ognjanović, M., Stanković, D., Fabián, M., Vukadinović, A., Prijović, Ž., Dojčinović, B. P.,& Antić, B.. (2018). A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone. in Electroanalysis.
https://doi.org/10.1002/elan.201800357
Kon_1315
Ognjanović M, Stanković D, Fabián M, Vukadinović A, Prijović Ž, Dojčinović BP, Antić B. A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone. in Electroanalysis. 2018;.
doi:10.1002/elan.201800357
Kon_1315 .
Ognjanović, Miloš, Stanković, Dalibor, Fabián, Martin, Vukadinović, Aleksandar, Prijović, Željko, Dojčinović, Biljana P., Antić, Bratislav, "A Voltammetric Sensor Based on MgFe2O4 Decorated on Reduced Graphene Oxide-modified Electrode for Sensitive and Simultaneous Determination of Catechol and Hydroquinone" in Electroanalysis (2018),
https://doi.org/10.1002/elan.201800357 .,
Kon_1315 .
12
12
13

Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone

Lakić, Mladen; Vukadinović, Aleksandar; Kalcher, Kurt; Nikolić, Aleksandar S.; Stanković, Dalibor

(Elsevier Science Bv, Amsterdam, 2016)

TY  - JOUR
AU  - Lakić, Mladen
AU  - Vukadinović, Aleksandar
AU  - Kalcher, Kurt
AU  - Nikolić, Aleksandar S.
AU  - Stanković, Dalibor
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2343
AB  - This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.
PB  - Elsevier Science Bv, Amsterdam
T2  - Talanta
T1  - Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone
VL  - 161
SP  - 668
EP  - 674
DO  - 10.1016/j.talanta.2016.09.029
UR  - Kon_3159
ER  - 
@article{
author = "Lakić, Mladen and Vukadinović, Aleksandar and Kalcher, Kurt and Nikolić, Aleksandar S. and Stanković, Dalibor",
year = "2016",
abstract = "This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Talanta",
title = "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone",
volume = "161",
pages = "668-674",
doi = "10.1016/j.talanta.2016.09.029",
url = "Kon_3159"
}
Lakić, M., Vukadinović, A., Kalcher, K., Nikolić, A. S.,& Stanković, D.. (2016). Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta
Elsevier Science Bv, Amsterdam., 161, 668-674.
https://doi.org/10.1016/j.talanta.2016.09.029
Kon_3159
Lakić M, Vukadinović A, Kalcher K, Nikolić AS, Stanković D. Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta. 2016;161:668-674.
doi:10.1016/j.talanta.2016.09.029
Kon_3159 .
Lakić, Mladen, Vukadinović, Aleksandar, Kalcher, Kurt, Nikolić, Aleksandar S., Stanković, Dalibor, "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone" in Talanta, 161 (2016):668-674,
https://doi.org/10.1016/j.talanta.2016.09.029 .,
Kon_3159 .
18
21
18

Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029

Lakić, Mladen; Vukadinović, Aleksandar; Kalcher, Kurt; Nikolić, Aleksandar S.; Stanković, Dalibor

(Elsevier Science Bv, Amsterdam, 2016)

TY  - DATA
AU  - Lakić, Mladen
AU  - Vukadinović, Aleksandar
AU  - Kalcher, Kurt
AU  - Nikolić, Aleksandar S.
AU  - Stanković, Dalibor
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3507
PB  - Elsevier Science Bv, Amsterdam
T2  - Talanta
T1  - Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029
ER  - 
@misc{
author = "Lakić, Mladen and Vukadinović, Aleksandar and Kalcher, Kurt and Nikolić, Aleksandar S. and Stanković, Dalibor",
year = "2016",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Talanta",
title = "Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029"
}
Lakić, M., Vukadinović, A., Kalcher, K., Nikolić, A. S.,& Stanković, D.. (2016). Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029. in Talanta
Elsevier Science Bv, Amsterdam..
Lakić M, Vukadinović A, Kalcher K, Nikolić AS, Stanković D. Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029. in Talanta. 2016;..
Lakić, Mladen, Vukadinović, Aleksandar, Kalcher, Kurt, Nikolić, Aleksandar S., Stanković, Dalibor, "Supplementary data for the article: Lakic, M.; Vukadinovic, A.; Kalcher, K.; Nikolic, A. S.; Stankovic, D. M. Effect of Cobalt Doping Level of Ferrites in Enhancing Sensitivity of Analytical Performances of Carbon Paste Electrode for Simultaneous Determination of Catechol and Hydroquinone. Talanta 2016, 161, 668–674. https://doi.org/10.1016/j.talanta.2016.09.029" in Talanta (2016).

Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent

Lakić, Mladen; Sabo, Ljubica; Ristić, Slavica; Savić, Aleksandar; Petričević, Saša; Nikolić, Nadežda; Vukadinović, Aleksandar; Janković, Drina; Sabo, Tibor; Vranješ-Đuric, Sanja

(Wiley, Hoboken, 2016)

TY  - JOUR
AU  - Lakić, Mladen
AU  - Sabo, Ljubica
AU  - Ristić, Slavica
AU  - Savić, Aleksandar
AU  - Petričević, Saša
AU  - Nikolić, Nadežda
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Sabo, Tibor
AU  - Vranješ-Đuric, Sanja
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2045
AB  - The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O'-diethylethylenediamine-N,N'-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L') and diacid ligand (L"), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m'(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley & Sons, Ltd.
PB  - Wiley, Hoboken
T2  - Applied Organometallic Chemistry
T1  - Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent
VL  - 30
IS  - 2
SP  - 81
EP  - 88
DO  - 10.1002/aoc.3401
UR  - Kon_3001
ER  - 
@article{
author = "Lakić, Mladen and Sabo, Ljubica and Ristić, Slavica and Savić, Aleksandar and Petričević, Saša and Nikolić, Nadežda and Vukadinović, Aleksandar and Janković, Drina and Sabo, Tibor and Vranješ-Đuric, Sanja",
year = "2016",
abstract = "The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O'-diethylethylenediamine-N,N'-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L') and diacid ligand (L"), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m'(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley & Sons, Ltd.",
publisher = "Wiley, Hoboken",
journal = "Applied Organometallic Chemistry",
title = "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent",
volume = "30",
number = "2",
pages = "81-88",
doi = "10.1002/aoc.3401",
url = "Kon_3001"
}
Lakić, M., Sabo, L., Ristić, S., Savić, A., Petričević, S., Nikolić, N., Vukadinović, A., Janković, D., Sabo, T.,& Vranješ-Đuric, S.. (2016). Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry
Wiley, Hoboken., 30(2), 81-88.
https://doi.org/10.1002/aoc.3401
Kon_3001
Lakić M, Sabo L, Ristić S, Savić A, Petričević S, Nikolić N, Vukadinović A, Janković D, Sabo T, Vranješ-Đuric S. Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry. 2016;30(2):81-88.
doi:10.1002/aoc.3401
Kon_3001 .
Lakić, Mladen, Sabo, Ljubica, Ristić, Slavica, Savić, Aleksandar, Petričević, Saša, Nikolić, Nadežda, Vukadinović, Aleksandar, Janković, Drina, Sabo, Tibor, Vranješ-Đuric, Sanja, "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O '-diethylethylenediamine-N,N '-di-3-propanoate as potential tumour diagnostic agent" in Applied Organometallic Chemistry, 30, no. 2 (2016):81-88,
https://doi.org/10.1002/aoc.3401 .,
Kon_3001 .
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