Milutinovic, Milica

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  • Milutinovic, Milica (2)
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Simultaneous UHPLC/DAD/( plus /-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies

Mišić, Danijela; Šiler, Branislav; Gašić, Uroš M.; Avramov, Stevan N.; Živković, Suzana; Nestorović Živković, Jasmina; Milutinovic, Milica; Tešić, Živoslav Lj.

(Wiley-Blackwell, Hoboken, 2015)

TY  - JOUR
AU  - Mišić, Danijela
AU  - Šiler, Branislav
AU  - Gašić, Uroš M.
AU  - Avramov, Stevan N.
AU  - Živković, Suzana
AU  - Nestorović Živković, Jasmina
AU  - Milutinovic, Milica
AU  - Tešić, Živoslav Lj.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1663
AB  - Introduction - Nepeta species contain a variety of secondary metabolites, including iridoid monoterpenes - nepetalactones and phenolic acids - that are considered the main bioactive constituents. This work represents the first attempt to comparatively explore variations in these two major groups of secondary metabolites within the genus. Objective - To develop an efficient analytical methodology for simultaneous analysis of nepetalactones and phenolic acids in methanol extracts of selected Nepeta species, and to evaluate its potential application in chemotaxonomic studies. Material and methods - A UHPLC combined with linear-trap quadrupole (LTQ) orbitrap MS method was used to characterise chemical diversity and complexity of phenolics among 12 selected Nepeta species. A targeted metabolomic approach using UHPLC coupled to a diode array detector (DAD) and combined with (+/-) heated electrospray ionisation (HESI) MS/MS was developed and validated for quantitative analysis of six hydroxycinnamic acid derivatives and four nepetalactones. Results - Phenolic profiling provided a valuable database of bioactive compounds in the plant group studied, including phenolic acids (hydroxybenzoic and hydroxycinnamic acids) and flavonoids (flavones, flavonols and flavanones). Principal component analysis and cluster analysis suggested the applicability of 10 targeted compounds as chemomarkers for chemotaxonomic studies. Pearson's correlation analysis revealed significant positive correlations between metabolites involved in different biosynthetic pathways (phenylpropanoid or monoterpenoid). Conclusion - The described targeted metabolomic approach proved to be highly beneficial in designing a phytochemical overview of the genus Nepeta, and might have applications in further clarification of phylogenetic relations. Furthermore, it has the potential to be implemented in a routine quality control of plant material and herbal preparations.
PB  - Wiley-Blackwell, Hoboken
T2  - Phytochemical Analysis
T1  - Simultaneous UHPLC/DAD/( plus /-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies
VL  - 26
IS  - 1
SP  - 72
EP  - 85
DO  - 10.1002/pca.2538
ER  - 
@article{
author = "Mišić, Danijela and Šiler, Branislav and Gašić, Uroš M. and Avramov, Stevan N. and Živković, Suzana and Nestorović Živković, Jasmina and Milutinovic, Milica and Tešić, Živoslav Lj.",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1663",
abstract = "Introduction - Nepeta species contain a variety of secondary metabolites, including iridoid monoterpenes - nepetalactones and phenolic acids - that are considered the main bioactive constituents. This work represents the first attempt to comparatively explore variations in these two major groups of secondary metabolites within the genus. Objective - To develop an efficient analytical methodology for simultaneous analysis of nepetalactones and phenolic acids in methanol extracts of selected Nepeta species, and to evaluate its potential application in chemotaxonomic studies. Material and methods - A UHPLC combined with linear-trap quadrupole (LTQ) orbitrap MS method was used to characterise chemical diversity and complexity of phenolics among 12 selected Nepeta species. A targeted metabolomic approach using UHPLC coupled to a diode array detector (DAD) and combined with (+/-) heated electrospray ionisation (HESI) MS/MS was developed and validated for quantitative analysis of six hydroxycinnamic acid derivatives and four nepetalactones. Results - Phenolic profiling provided a valuable database of bioactive compounds in the plant group studied, including phenolic acids (hydroxybenzoic and hydroxycinnamic acids) and flavonoids (flavones, flavonols and flavanones). Principal component analysis and cluster analysis suggested the applicability of 10 targeted compounds as chemomarkers for chemotaxonomic studies. Pearson's correlation analysis revealed significant positive correlations between metabolites involved in different biosynthetic pathways (phenylpropanoid or monoterpenoid). Conclusion - The described targeted metabolomic approach proved to be highly beneficial in designing a phytochemical overview of the genus Nepeta, and might have applications in further clarification of phylogenetic relations. Furthermore, it has the potential to be implemented in a routine quality control of plant material and herbal preparations.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytochemical Analysis",
title = "Simultaneous UHPLC/DAD/( plus /-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies",
volume = "26",
number = "1",
pages = "72-85",
doi = "10.1002/pca.2538"
}
Mišić, D., Šiler, B., Gašić, U. M., Avramov, S. N., Živković, S., Nestorović Živković, J., Milutinovic, M.,& Tešić, Ž. Lj. (2015). Simultaneous UHPLC/DAD/( plus /-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies.
Phytochemical Analysis
Wiley-Blackwell, Hoboken., 26(1), 72-85.
https://doi.org/10.1002/pca.2538
Mišić D, Šiler B, Gašić UM, Avramov SN, Živković S, Nestorović Živković J, Milutinovic M, Tešić ŽL. Simultaneous UHPLC/DAD/( plus /-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis. 2015;26(1):72-85
Mišić Danijela, Šiler Branislav, Gašić Uroš M., Avramov Stevan N., Živković Suzana, Nestorović Živković Jasmina, Milutinovic Milica, Tešić Živoslav Lj., "Simultaneous UHPLC/DAD/( plus /-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies" Phytochemical Analysis, 26, no. 1 (2015):72-85,
https://doi.org/10.1002/pca.2538 .
50
46
50

Supplementary data for article: Mišić, D.; Šiler, B.; Gašić, U.; Avramov, S.; Živković, S.; Živković, J. N.; Milutinović, M.; Tešić, Ž. Simultaneous UHPLC/DAD/(+/-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis 2015, 26 (1), 72–85. https://doi.org/10.1002/pca.2538

Mišić, Danijela; Šiler, Branislav; Gašić, Uroš M.; Avramov, Stevan N.; Živković, Suzana; Nestorović Živković, Jasmina; Milutinovic, Milica; Tešić, Živoslav Lj.

(Wiley-Blackwell, Hoboken, 2015)

TY  - BOOK
AU  - Mišić, Danijela
AU  - Šiler, Branislav
AU  - Gašić, Uroš M.
AU  - Avramov, Stevan N.
AU  - Živković, Suzana
AU  - Nestorović Živković, Jasmina
AU  - Milutinovic, Milica
AU  - Tešić, Živoslav Lj.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3420
PB  - Wiley-Blackwell, Hoboken
T2  - Phytochemical Analysis
T1  - Supplementary data for article: Mišić, D.; Šiler, B.; Gašić, U.; Avramov, S.; Živković, S.; Živković, J. N.; Milutinović, M.; Tešić, Ž. Simultaneous UHPLC/DAD/(+/-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis 2015, 26 (1), 72–85. https://doi.org/10.1002/pca.2538
ER  - 
@book{
author = "Mišić, Danijela and Šiler, Branislav and Gašić, Uroš M. and Avramov, Stevan N. and Živković, Suzana and Nestorović Živković, Jasmina and Milutinovic, Milica and Tešić, Živoslav Lj.",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3420",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytochemical Analysis",
title = "Supplementary data for article: Mišić, D.; Šiler, B.; Gašić, U.; Avramov, S.; Živković, S.; Živković, J. N.; Milutinović, M.; Tešić, Ž. Simultaneous UHPLC/DAD/(+/-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis 2015, 26 (1), 72–85. https://doi.org/10.1002/pca.2538"
}
Mišić, D., Šiler, B., Gašić, U. M., Avramov, S. N., Živković, S., Nestorović Živković, J., Milutinovic, M.,& Tešić, Ž. Lj. (2015). Supplementary data for article: Mišić, D.; Šiler, B.; Gašić, U.; Avramov, S.; Živković, S.; Živković, J. N.; Milutinović, M.; Tešić, Ž. Simultaneous UHPLC/DAD/(+/-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis 2015, 26 (1), 72–85. https://doi.org/10.1002/pca.2538.
Phytochemical Analysis
Wiley-Blackwell, Hoboken..
Mišić D, Šiler B, Gašić UM, Avramov SN, Živković S, Nestorović Živković J, Milutinovic M, Tešić ŽL. Supplementary data for article: Mišić, D.; Šiler, B.; Gašić, U.; Avramov, S.; Živković, S.; Živković, J. N.; Milutinović, M.; Tešić, Ž. Simultaneous UHPLC/DAD/(+/-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis 2015, 26 (1), 72–85. https://doi.org/10.1002/pca.2538. Phytochemical Analysis. 2015;
Mišić Danijela, Šiler Branislav, Gašić Uroš M., Avramov Stevan N., Živković Suzana, Nestorović Živković Jasmina, Milutinovic Milica, Tešić Živoslav Lj., "Supplementary data for article: Mišić, D.; Šiler, B.; Gašić, U.; Avramov, S.; Živković, S.; Živković, J. N.; Milutinović, M.; Tešić, Ž. Simultaneous UHPLC/DAD/(+/-)HESI-MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies. Phytochemical Analysis 2015, 26 (1), 72–85. https://doi.org/10.1002/pca.2538" Phytochemical Analysis (2015)