TY  - JOUR
AU  - Mojic, Marija
AU  - Savić, Aleksandar
AU  - Arion, Vladimir B.
AU  - Bulatović, Mirna Z.
AU  - Poljarević, Jelena
AU  - Miljković, Đorđe
AU  - Sabo, Tibor
AU  - Mijatovic, Sanja
AU  - Maksimovic-Ivanic, Danijela
AU  - Grgurić-Šipka, Sanja
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1450
AB  - Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50  gt  50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50  gt  120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes
VL  - 749
SP  - 142
EP  - 149
DO  - 10.1016/j.jorganchem.2013.08.041
ER  - 

@article{
author = "Mojic, Marija and Savić, Aleksandar and Arion, Vladimir B. and Bulatović, Mirna Z. and Poljarević, Jelena and Miljković, Đorđe and Sabo, Tibor and Mijatovic, Sanja and Maksimovic-Ivanic, Danijela and Grgurić-Šipka, Sanja",
year = "2014",
abstract = "Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50  gt  50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50  gt  120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes",
volume = "749",
pages = "142-149",
doi = "10.1016/j.jorganchem.2013.08.041"
}

Mojic, M., Savić, A., Arion, V. B., Bulatović, M. Z., Poljarević, J., Miljković, Đ., Sabo, T., Mijatovic, S., Maksimovic-Ivanic, D.,& Grgurić-Šipka, S.. (2014). Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes. in Journal of Organometallic Chemistry
Elsevier Science Sa, Lausanne., 749, 142-149.
https://doi.org/10.1016/j.jorganchem.2013.08.041

Mojic M, Savić A, Arion VB, Bulatović MZ, Poljarević J, Miljković Đ, Sabo T, Mijatovic S, Maksimovic-Ivanic D, Grgurić-Šipka S. Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes. in Journal of Organometallic Chemistry. 2014;749:142-149.
doi:10.1016/j.jorganchem.2013.08.041 .

Mojic, Marija, Savić, Aleksandar, Arion, Vladimir B., Bulatović, Mirna Z., Poljarević, Jelena, Miljković, Đorđe, Sabo, Tibor, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Grgurić-Šipka, Sanja, "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes" in Journal of Organometallic Chemistry, 749 (2014):142-149,
https://doi.org/10.1016/j.jorganchem.2013.08.041 . .

TY  - JOUR
AU  - Nikodinović-Runić, Jasmina
AU  - Mojic, Marija
AU  - Kang, Yijin
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Vasiljević, Branka
AU  - Stamenković, Vojislav R.
AU  - Šenerović, Lidija
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1776
AB  - Bacterial pigment undecylprodigiosin (UP) was produced using Streptomyces sp. JS520 and conjugated to monodisperse gold nanoparticles (UP-Au). Both UP and UP-Au showed cytocidal activity towards melanoma (A375), lung carcinoma (A549), breast cancer (MCF-7) and colon cancer (HCT-116) cells, inducing apoptosis with IC50 values ranging from 0.4 to 4 mu g ml(-1). Unconjugated UP had a tendency to lose its activity over time and to change biophysical characteristics over pH. The loss of the pigment potency was overcome by conjugation with gold nanoparticles. UP-Au exhibited high stability over pH 3.8 to 7.4 and its activity remained unaffected in time. Nano-packing changed the mechanism of UP toxicity by converting the intracellular signals from a mitochondrial dependent to a mitochondrial independent apoptotic process. The availability of nonpyrogenic UP in high amounts, together with specific anticancer activity and improved stability in the complex with gold nanoparticles, presents a novel platform for further development of UP-Au complexes as an anticancer drug suitable for clinical applications.
PB  - Royal Soc Chemistry, Cambridge
T2  - Journal of Materials Chemistry. B
T1  - Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro
VL  - 2
IS  - 21
SP  - 3271
EP  - 3281
DO  - 10.1039/c4tb00300d
ER  - 

@article{
author = "Nikodinović-Runić, Jasmina and Mojic, Marija and Kang, Yijin and Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Vasiljević, Branka and Stamenković, Vojislav R. and Šenerović, Lidija",
year = "2014",
abstract = "Bacterial pigment undecylprodigiosin (UP) was produced using Streptomyces sp. JS520 and conjugated to monodisperse gold nanoparticles (UP-Au). Both UP and UP-Au showed cytocidal activity towards melanoma (A375), lung carcinoma (A549), breast cancer (MCF-7) and colon cancer (HCT-116) cells, inducing apoptosis with IC50 values ranging from 0.4 to 4 mu g ml(-1). Unconjugated UP had a tendency to lose its activity over time and to change biophysical characteristics over pH. The loss of the pigment potency was overcome by conjugation with gold nanoparticles. UP-Au exhibited high stability over pH 3.8 to 7.4 and its activity remained unaffected in time. Nano-packing changed the mechanism of UP toxicity by converting the intracellular signals from a mitochondrial dependent to a mitochondrial independent apoptotic process. The availability of nonpyrogenic UP in high amounts, together with specific anticancer activity and improved stability in the complex with gold nanoparticles, presents a novel platform for further development of UP-Au complexes as an anticancer drug suitable for clinical applications.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Journal of Materials Chemistry. B",
title = "Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro",
volume = "2",
number = "21",
pages = "3271-3281",
doi = "10.1039/c4tb00300d"
}

Nikodinović-Runić, J., Mojic, M., Kang, Y., Maksimovic-Ivanic, D., Mijatovic, S., Vasiljević, B., Stamenković, V. R.,& Šenerović, L.. (2014). Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro. in Journal of Materials Chemistry. B
Royal Soc Chemistry, Cambridge., 2(21), 3271-3281.
https://doi.org/10.1039/c4tb00300d

Nikodinović-Runić J, Mojic M, Kang Y, Maksimovic-Ivanic D, Mijatovic S, Vasiljević B, Stamenković VR, Šenerović L. Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro. in Journal of Materials Chemistry. B. 2014;2(21):3271-3281.
doi:10.1039/c4tb00300d .

Nikodinović-Runić, Jasmina, Mojic, Marija, Kang, Yijin, Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Vasiljević, Branka, Stamenković, Vojislav R., Šenerović, Lidija, "Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro" in Journal of Materials Chemistry. B, 2, no. 21 (2014):3271-3281,
https://doi.org/10.1039/c4tb00300d . .

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Savić, Aleksandar
AU  - Poljarević, Jelena
AU  - Vučković, Ivan M.
AU  - Mojic, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava D.
AU  - Miljković, Đorđe
AU  - Grgurić-Šipka, Sanja
AU  - Sabo, Tibor
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1283
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
VL  - 109
SP  - 40
EP  - 48
DO  - 10.1016/j.jinorgbio.2012.01.012
ER  - 

@article{
author = "Mihajlović-Lalić, Ljiljana and Savić, Aleksandar and Poljarević, Jelena and Vučković, Ivan M. and Mojic, Marija and Bulatović, Mirna Z. and Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava D. and Miljković, Đorđe and Grgurić-Šipka, Sanja and Sabo, Tibor",
year = "2012",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
volume = "109",
pages = "40-48",
doi = "10.1016/j.jinorgbio.2012.01.012"
}

Mihajlović-Lalić, L., Savić, A., Poljarević, J., Vučković, I. M., Mojic, M., Bulatović, M. Z., Maksimovic-Ivanic, D., Mijatovic, S., Kaluđerović, G. N., Stošić-Grujičić, S. D., Miljković, Đ., Grgurić-Šipka, S.,& Sabo, T.. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 109, 40-48.
https://doi.org/10.1016/j.jinorgbio.2012.01.012

Mihajlović-Lalić L, Savić A, Poljarević J, Vučković IM, Mojic M, Bulatović MZ, Maksimovic-Ivanic D, Mijatovic S, Kaluđerović GN, Stošić-Grujičić SD, Miljković Đ, Grgurić-Šipka S, Sabo T. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry. 2012;109:40-48.
doi:10.1016/j.jinorgbio.2012.01.012 .

Mihajlović-Lalić, Ljiljana, Savić, Aleksandar, Poljarević, Jelena, Vučković, Ivan M., Mojic, Marija, Bulatović, Mirna Z., Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava D., Miljković, Đorđe, Grgurić-Šipka, Sanja, Sabo, Tibor, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" in Journal of Inorganic Biochemistry, 109 (2012):40-48,
https://doi.org/10.1016/j.jinorgbio.2012.01.012 . .

TY  - JOUR
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Mirkov, Ivana
AU  - Stošić-Grujičić, Stanislava D.
AU  - Miljković, Đorđe
AU  - Sabo, Tibor
AU  - Trajković, Vladimir S.
AU  - Kaluđerović, Goran N.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1551
AB  - Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations
VL  - 4
IS  - 11
SP  - 1155
EP  - 1159
DO  - 10.1039/c2mt20150j
ER  - 

@article{
author = "Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Mirkov, Ivana and Stošić-Grujičić, Stanislava D. and Miljković, Đorđe and Sabo, Tibor and Trajković, Vladimir S. and Kaluđerović, Goran N.",
year = "2012",
abstract = "Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations",
volume = "4",
number = "11",
pages = "1155-1159",
doi = "10.1039/c2mt20150j"
}

Maksimovic-Ivanic, D., Mijatovic, S., Mirkov, I., Stošić-Grujičić, S. D., Miljković, Đ., Sabo, T., Trajković, V. S.,& Kaluđerović, G. N.. (2012). Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. in Metallomics
Royal Soc Chemistry, Cambridge., 4(11), 1155-1159.
https://doi.org/10.1039/c2mt20150j

Maksimovic-Ivanic D, Mijatovic S, Mirkov I, Stošić-Grujičić SD, Miljković Đ, Sabo T, Trajković VS, Kaluđerović GN. Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. in Metallomics. 2012;4(11):1155-1159.
doi:10.1039/c2mt20150j .

Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Mirkov, Ivana, Stošić-Grujičić, Stanislava D., Miljković, Đorđe, Sabo, Tibor, Trajković, Vladimir S., Kaluđerović, Goran N., "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations" in Metallomics, 4, no. 11 (2012):1155-1159,
https://doi.org/10.1039/c2mt20150j . .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatovic, Sanja A.
AU  - Zmejkovski, Bojana B.
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojic, Marija K.
AU  - Steinborn, Dirk
AU  - Miljkovic, Djordje M.
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava D.
AU  - Sabo, Tibor
AU  - Maksimovic-Ivanic, Danijela D.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1523
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
VL  - 4
IS  - 9
SP  - 979
EP  - 987
DO  - 10.1039/c2mt20058a
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatovic, Sanja A. and Zmejkovski, Bojana B. and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojic, Marija K. and Steinborn, Dirk and Miljkovic, Djordje M. and Schmidt, Harry and Stošić-Grujičić, Stanislava D. and Sabo, Tibor and Maksimovic-Ivanic, Danijela D.",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
volume = "4",
number = "9",
pages = "979-987",
doi = "10.1039/c2mt20058a"
}

Kaluđerović, G. N., Mijatovic, S. A., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojic, M. K., Steinborn, D., Miljkovic, D. M., Schmidt, H., Stošić-Grujičić, S. D., Sabo, T.,& Maksimovic-Ivanic, D. D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics
Royal Soc Chemistry, Cambridge., 4(9), 979-987.
https://doi.org/10.1039/c2mt20058a

Kaluđerović GN, Mijatovic SA, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojic MK, Steinborn D, Miljkovic DM, Schmidt H, Stošić-Grujičić SD, Sabo T, Maksimovic-Ivanic DD. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):979-987.
doi:10.1039/c2mt20058a .

Kaluđerović, Goran N., Mijatovic, Sanja A., Zmejkovski, Bojana B., Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojic, Marija K., Steinborn, Dirk, Miljkovic, Djordje M., Schmidt, Harry, Stošić-Grujičić, Stanislava D., Sabo, Tibor, Maksimovic-Ivanic, Danijela D., "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012):979-987,
https://doi.org/10.1039/c2mt20058a . .

TY  - JOUR
AU  - Mijatovic, S
AU  - Maksimovic-Ivanic, D
AU  - Radovic, J
AU  - Miljković, Đorđe
AU  - Kaludjerovic, GN
AU  - Sabo, Tibor
AU  - Trajković, Vladimir S.
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/733
AB  - The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of DNA fragmentation or phosphatidylserine exposure. Cell-based ELISA and Western blot analysis revealed that AE abolished cisplatin-triggered activation of extracellular signal-regulated kinase (ERK) in tumor cells, while activation of c-Jun N-terminal kinase was not significantly altered. A selective blockade of ERK activation with PD98059 mimicked the protective effect of AE treatment in both tumor cell lines. Moreover, AE failed to protect tumor cells against the ERK-independent toxicity of the Pt(IV)-based complex tetrachloro(O,O-dibutyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV). Taken together, these data indicate that herbal anthraquinone AE can downregulate the anticancer activity of cisplatin by blocking the activation of ERK in tumor cells.
PB  - Birkhauser Verlag Ag, Basel
T2  - Cellular and Molecular Life Sciences / CMLS
T1  - Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin
VL  - 62
IS  - 11
SP  - 1275
EP  - 1282
DO  - 10.1007/s00018-005-5041-3
ER  - 

@article{
author = "Mijatovic, S and Maksimovic-Ivanic, D and Radovic, J and Miljković, Đorđe and Kaludjerovic, GN and Sabo, Tibor and Trajković, Vladimir S.",
year = "2005",
abstract = "The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of DNA fragmentation or phosphatidylserine exposure. Cell-based ELISA and Western blot analysis revealed that AE abolished cisplatin-triggered activation of extracellular signal-regulated kinase (ERK) in tumor cells, while activation of c-Jun N-terminal kinase was not significantly altered. A selective blockade of ERK activation with PD98059 mimicked the protective effect of AE treatment in both tumor cell lines. Moreover, AE failed to protect tumor cells against the ERK-independent toxicity of the Pt(IV)-based complex tetrachloro(O,O-dibutyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV). Taken together, these data indicate that herbal anthraquinone AE can downregulate the anticancer activity of cisplatin by blocking the activation of ERK in tumor cells.",
publisher = "Birkhauser Verlag Ag, Basel",
journal = "Cellular and Molecular Life Sciences / CMLS",
title = "Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin",
volume = "62",
number = "11",
pages = "1275-1282",
doi = "10.1007/s00018-005-5041-3"
}

Mijatovic, S., Maksimovic-Ivanic, D., Radovic, J., Miljković, Đ., Kaludjerovic, G., Sabo, T.,& Trajković, V. S.. (2005). Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. in Cellular and Molecular Life Sciences / CMLS
Birkhauser Verlag Ag, Basel., 62(11), 1275-1282.
https://doi.org/10.1007/s00018-005-5041-3

Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljković Đ, Kaludjerovic G, Sabo T, Trajković VS. Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. in Cellular and Molecular Life Sciences / CMLS. 2005;62(11):1275-1282.
doi:10.1007/s00018-005-5041-3 .

Mijatovic, S, Maksimovic-Ivanic, D, Radovic, J, Miljković, Đorđe, Kaludjerovic, GN, Sabo, Tibor, Trajković, Vladimir S., "Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin" in Cellular and Molecular Life Sciences / CMLS, 62, no. 11 (2005):1275-1282,
https://doi.org/10.1007/s00018-005-5041-3 . .