TY  - JOUR
AU  - Samardžić, Stevan
AU  - Arsenijević, Jelena
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Tešević, Vele
AU  - Maksimović, Zoran
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2068
AB  - Ethnopharmacological relevance: Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and antiulcer properties. Aim of the study: To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin IL Materials and methods: Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis.. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol. Results: LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC50 = 5.1 mu g/mL). Among tested samples, astragalin 2 ''-O-gallate (IC50 = 141.1 mu g/mL) and spiraeoside (IC50 = 4.69 mu g/mL) the most markedly inhibited production of pro -inflammatory prostaglandin E-2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300 mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50 mg/kg, p.o.) and tellimagrandin II (40 mg/kg, p.o.) showed ulcer preventive ability. Conclusion: Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench
VL  - 213
SP  - 132
EP  - 137
DO  - 10.1016/j.jep.2017.11.013
ER  - 

@article{
author = "Samardžić, Stevan and Arsenijević, Jelena and Božić, Dragana and Milenković, Marina and Tešević, Vele and Maksimović, Zoran",
year = "2018",
abstract = "Ethnopharmacological relevance: Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and antiulcer properties. Aim of the study: To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin IL Materials and methods: Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis.. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol. Results: LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC50 = 5.1 mu g/mL). Among tested samples, astragalin 2 ''-O-gallate (IC50 = 141.1 mu g/mL) and spiraeoside (IC50 = 4.69 mu g/mL) the most markedly inhibited production of pro -inflammatory prostaglandin E-2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300 mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50 mg/kg, p.o.) and tellimagrandin II (40 mg/kg, p.o.) showed ulcer preventive ability. Conclusion: Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench",
volume = "213",
pages = "132-137",
doi = "10.1016/j.jep.2017.11.013"
}

Samardžić, S., Arsenijević, J., Božić, D., Milenković, M., Tešević, V.,& Maksimović, Z.. (2018). Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare., 213, 132-137.
https://doi.org/10.1016/j.jep.2017.11.013

Samardžić S, Arsenijević J, Božić D, Milenković M, Tešević V, Maksimović Z. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. in Journal of Ethnopharmacology. 2018;213:132-137.
doi:10.1016/j.jep.2017.11.013 .

Samardžić, Stevan, Arsenijević, Jelena, Božić, Dragana, Milenković, Marina, Tešević, Vele, Maksimović, Zoran, "Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench" in Journal of Ethnopharmacology, 213 (2018):132-137,
https://doi.org/10.1016/j.jep.2017.11.013 . .

TY  - JOUR
AU  - Samardžić, Stevan
AU  - Arsenijević, Jelena
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Tešević, Vele
AU  - Maksimović, Zoran
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3153
AB  - Ethnopharmacological relevance: Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and antiulcer properties. Aim of the study: To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin IL Materials and methods: Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis.. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol. Results: LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC50 = 5.1 mu g/mL). Among tested samples, astragalin 2 ''-O-gallate (IC50 = 141.1 mu g/mL) and spiraeoside (IC50 = 4.69 mu g/mL) the most markedly inhibited production of pro -inflammatory prostaglandin E-2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300 mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50 mg/kg, p.o.) and tellimagrandin II (40 mg/kg, p.o.) showed ulcer preventive ability. Conclusion: Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench
VL  - 213
SP  - 132
EP  - 137
DO  - 10.1016/j.jep.2017.11.013
ER  - 

@article{
author = "Samardžić, Stevan and Arsenijević, Jelena and Božić, Dragana and Milenković, Marina and Tešević, Vele and Maksimović, Zoran",
year = "2018",
abstract = "Ethnopharmacological relevance: Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and antiulcer properties. Aim of the study: To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin IL Materials and methods: Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis.. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol. Results: LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC50 = 5.1 mu g/mL). Among tested samples, astragalin 2 ''-O-gallate (IC50 = 141.1 mu g/mL) and spiraeoside (IC50 = 4.69 mu g/mL) the most markedly inhibited production of pro -inflammatory prostaglandin E-2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300 mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50 mg/kg, p.o.) and tellimagrandin II (40 mg/kg, p.o.) showed ulcer preventive ability. Conclusion: Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench",
volume = "213",
pages = "132-137",
doi = "10.1016/j.jep.2017.11.013"
}

Samardžić, S., Arsenijević, J., Božić, D., Milenković, M., Tešević, V.,& Maksimović, Z.. (2018). Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare., 213, 132-137.
https://doi.org/10.1016/j.jep.2017.11.013

Samardžić S, Arsenijević J, Božić D, Milenković M, Tešević V, Maksimović Z. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. in Journal of Ethnopharmacology. 2018;213:132-137.
doi:10.1016/j.jep.2017.11.013 .

Samardžić, Stevan, Arsenijević, Jelena, Božić, Dragana, Milenković, Marina, Tešević, Vele, Maksimović, Zoran, "Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench" in Journal of Ethnopharmacology, 213 (2018):132-137,
https://doi.org/10.1016/j.jep.2017.11.013 . .

TY  - DATA
AU  - Samardžić, Stevan
AU  - Arsenijević, Jelena
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Tešević, Vele
AU  - Maksimović, Zoran
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3154
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Supplementary material for the article: Samardžić, S.; Arsenijević, J.; Božić, D.; Milenković, M.; Tešević, V.; Maksimović, Z. Antioxidant, Anti-Inflammatory and Gastroprotective Activity of Filipendula Ulmaria (L.) Maxim. and Filipendula Vulgaris Moench. Journal of Ethnopharmacology 2018, 213, 132–137. https://doi.org/10.1016/j.jep.2017.11.013
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3154
ER  - 

@misc{
author = "Samardžić, Stevan and Arsenijević, Jelena and Božić, Dragana and Milenković, Marina and Tešević, Vele and Maksimović, Zoran",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Supplementary material for the article: Samardžić, S.; Arsenijević, J.; Božić, D.; Milenković, M.; Tešević, V.; Maksimović, Z. Antioxidant, Anti-Inflammatory and Gastroprotective Activity of Filipendula Ulmaria (L.) Maxim. and Filipendula Vulgaris Moench. Journal of Ethnopharmacology 2018, 213, 132–137. https://doi.org/10.1016/j.jep.2017.11.013",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3154"
}

Samardžić, S., Arsenijević, J., Božić, D., Milenković, M., Tešević, V.,& Maksimović, Z.. (2018). Supplementary material for the article: Samardžić, S.; Arsenijević, J.; Božić, D.; Milenković, M.; Tešević, V.; Maksimović, Z. Antioxidant, Anti-Inflammatory and Gastroprotective Activity of Filipendula Ulmaria (L.) Maxim. and Filipendula Vulgaris Moench. Journal of Ethnopharmacology 2018, 213, 132–137. https://doi.org/10.1016/j.jep.2017.11.013. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare..
https://hdl.handle.net/21.15107/rcub_cherry_3154

Samardžić S, Arsenijević J, Božić D, Milenković M, Tešević V, Maksimović Z. Supplementary material for the article: Samardžić, S.; Arsenijević, J.; Božić, D.; Milenković, M.; Tešević, V.; Maksimović, Z. Antioxidant, Anti-Inflammatory and Gastroprotective Activity of Filipendula Ulmaria (L.) Maxim. and Filipendula Vulgaris Moench. Journal of Ethnopharmacology 2018, 213, 132–137. https://doi.org/10.1016/j.jep.2017.11.013. in Journal of Ethnopharmacology. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3154 .

Samardžić, Stevan, Arsenijević, Jelena, Božić, Dragana, Milenković, Marina, Tešević, Vele, Maksimović, Zoran, "Supplementary material for the article: Samardžić, S.; Arsenijević, J.; Božić, D.; Milenković, M.; Tešević, V.; Maksimović, Z. Antioxidant, Anti-Inflammatory and Gastroprotective Activity of Filipendula Ulmaria (L.) Maxim. and Filipendula Vulgaris Moench. Journal of Ethnopharmacology 2018, 213, 132–137. https://doi.org/10.1016/j.jep.2017.11.013" in Journal of Ethnopharmacology (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3154 .