TY  - JOUR
AU  - Nikodijević, Danijela D.
AU  - Milutinović, Milena G.
AU  - Cvetković, Danijela M.
AU  - Ćupurdija, Maja Đ.
AU  - Jovanović, Milena M.
AU  - Mrkić, Ivan V.
AU  - Gavrović-Jankulović, Marija
AU  - Marković, Snežana D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4974
AB  - This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.
PB  - Taylor & Francis
T2  - Toxin Reviews
T1  - Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines
VL  - 40
IS  - 4
SP  - 1272
EP  - 1279
DO  - 10.1080/15569543.2019.1680564
ER  - 

@article{
author = "Nikodijević, Danijela D. and Milutinović, Milena G. and Cvetković, Danijela M. and Ćupurdija, Maja Đ. and Jovanović, Milena M. and Mrkić, Ivan V. and Gavrović-Jankulović, Marija and Marković, Snežana D.",
year = "2021",
abstract = "This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.",
publisher = "Taylor & Francis",
journal = "Toxin Reviews",
title = "Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines",
volume = "40",
number = "4",
pages = "1272-1279",
doi = "10.1080/15569543.2019.1680564"
}

Nikodijević, D. D., Milutinović, M. G., Cvetković, D. M., Ćupurdija, M. Đ., Jovanović, M. M., Mrkić, I. V., Gavrović-Jankulović, M.,& Marković, S. D.. (2021). Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. in Toxin Reviews
Taylor & Francis., 40(4), 1272-1279.
https://doi.org/10.1080/15569543.2019.1680564

Nikodijević DD, Milutinović MG, Cvetković DM, Ćupurdija MĐ, Jovanović MM, Mrkić IV, Gavrović-Jankulović M, Marković SD. Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. in Toxin Reviews. 2021;40(4):1272-1279.
doi:10.1080/15569543.2019.1680564 .

Nikodijević, Danijela D., Milutinović, Milena G., Cvetković, Danijela M., Ćupurdija, Maja Đ., Jovanović, Milena M., Mrkić, Ivan V., Gavrović-Jankulović, Marija, Marković, Snežana D., "Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines" in Toxin Reviews, 40, no. 4 (2021):1272-1279,
https://doi.org/10.1080/15569543.2019.1680564 . .

TY  - DATA
AU  - Nikodijević, Danijela D.
AU  - Milutinović, Milena G.
AU  - Cvetković, Danijela M.
AU  - Ćupurdija, Maja Đ.
AU  - Jovanović, Milena M.
AU  - Mrkić, Ivan V.
AU  - Gavrović-Jankulović, Marija
AU  - Marković, Snežana D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4975
PB  - Taylor & Francis
T2  - Toxin Reviews
T1  - Supplementary data for the article: Nikodijević, D. D.; Milutinović, M. G.; Cvetković, D. M.; Ćupurdija, M. Đ.; Jovanović, M. M.; Mrkić, I. V.; Jankulović-Gavrović, M. Đ.; Marković, S. D. Impact of Bee Venom and Melittin on Apoptosis and Biotransformation in Colorectal Carcinoma Cell Lines. Toxin Reviews 2021, 40 (4), 1272–1279. https://doi.org/10.1080/15569543.2019.1680564.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4975
ER  - 

@misc{
author = "Nikodijević, Danijela D. and Milutinović, Milena G. and Cvetković, Danijela M. and Ćupurdija, Maja Đ. and Jovanović, Milena M. and Mrkić, Ivan V. and Gavrović-Jankulović, Marija and Marković, Snežana D.",
year = "2021",
publisher = "Taylor & Francis",
journal = "Toxin Reviews",
title = "Supplementary data for the article: Nikodijević, D. D.; Milutinović, M. G.; Cvetković, D. M.; Ćupurdija, M. Đ.; Jovanović, M. M.; Mrkić, I. V.; Jankulović-Gavrović, M. Đ.; Marković, S. D. Impact of Bee Venom and Melittin on Apoptosis and Biotransformation in Colorectal Carcinoma Cell Lines. Toxin Reviews 2021, 40 (4), 1272–1279. https://doi.org/10.1080/15569543.2019.1680564.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4975"
}

Nikodijević, D. D., Milutinović, M. G., Cvetković, D. M., Ćupurdija, M. Đ., Jovanović, M. M., Mrkić, I. V., Gavrović-Jankulović, M.,& Marković, S. D.. (2021). Supplementary data for the article: Nikodijević, D. D.; Milutinović, M. G.; Cvetković, D. M.; Ćupurdija, M. Đ.; Jovanović, M. M.; Mrkić, I. V.; Jankulović-Gavrović, M. Đ.; Marković, S. D. Impact of Bee Venom and Melittin on Apoptosis and Biotransformation in Colorectal Carcinoma Cell Lines. Toxin Reviews 2021, 40 (4), 1272–1279. https://doi.org/10.1080/15569543.2019.1680564.. in Toxin Reviews
Taylor & Francis..
https://hdl.handle.net/21.15107/rcub_cherry_4975

Nikodijević DD, Milutinović MG, Cvetković DM, Ćupurdija MĐ, Jovanović MM, Mrkić IV, Gavrović-Jankulović M, Marković SD. Supplementary data for the article: Nikodijević, D. D.; Milutinović, M. G.; Cvetković, D. M.; Ćupurdija, M. Đ.; Jovanović, M. M.; Mrkić, I. V.; Jankulović-Gavrović, M. Đ.; Marković, S. D. Impact of Bee Venom and Melittin on Apoptosis and Biotransformation in Colorectal Carcinoma Cell Lines. Toxin Reviews 2021, 40 (4), 1272–1279. https://doi.org/10.1080/15569543.2019.1680564.. in Toxin Reviews. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4975 .

Nikodijević, Danijela D., Milutinović, Milena G., Cvetković, Danijela M., Ćupurdija, Maja Đ., Jovanović, Milena M., Mrkić, Ivan V., Gavrović-Jankulović, Marija, Marković, Snežana D., "Supplementary data for the article: Nikodijević, D. D.; Milutinović, M. G.; Cvetković, D. M.; Ćupurdija, M. Đ.; Jovanović, M. M.; Mrkić, I. V.; Jankulović-Gavrović, M. Đ.; Marković, S. D. Impact of Bee Venom and Melittin on Apoptosis and Biotransformation in Colorectal Carcinoma Cell Lines. Toxin Reviews 2021, 40 (4), 1272–1279. https://doi.org/10.1080/15569543.2019.1680564." in Toxin Reviews (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4975 .

TY  - JOUR
AU  - Žižić, Jovana B.
AU  - Vuković, Nenad L.
AU  - Jadranin, Milka
AU  - Anđelković, Boban D.
AU  - Tešević, Vele
AU  - Kacaniova, Miroslava M.
AU  - Sukdolak, Slobodan B.
AU  - Marković, Snežana D.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3472
AB  - BACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis (EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 mu gmg(-1)), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 mu gmL(-1). Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food and Agriculture
T1  - Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line
VL  - 93
IS  - 12
SP  - 3001
EP  - 3009
DO  - 10.1002/jsfa.6132
ER  - 

@article{
author = "Žižić, Jovana B. and Vuković, Nenad L. and Jadranin, Milka and Anđelković, Boban D. and Tešević, Vele and Kacaniova, Miroslava M. and Sukdolak, Slobodan B. and Marković, Snežana D.",
year = "2013",
abstract = "BACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis (EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 mu gmg(-1)), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 mu gmL(-1). Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food and Agriculture",
title = "Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line",
volume = "93",
number = "12",
pages = "3001-3009",
doi = "10.1002/jsfa.6132"
}

Žižić, J. B., Vuković, N. L., Jadranin, M., Anđelković, B. D., Tešević, V., Kacaniova, M. M., Sukdolak, S. B.,& Marković, S. D.. (2013). Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. in Journal of the Science of Food and Agriculture
Wiley, Hoboken., 93(12), 3001-3009.
https://doi.org/10.1002/jsfa.6132

Žižić JB, Vuković NL, Jadranin M, Anđelković BD, Tešević V, Kacaniova MM, Sukdolak SB, Marković SD. Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. in Journal of the Science of Food and Agriculture. 2013;93(12):3001-3009.
doi:10.1002/jsfa.6132 .

Žižić, Jovana B., Vuković, Nenad L., Jadranin, Milka, Anđelković, Boban D., Tešević, Vele, Kacaniova, Miroslava M., Sukdolak, Slobodan B., Marković, Snežana D., "Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line" in Journal of the Science of Food and Agriculture, 93, no. 12 (2013):3001-3009,
https://doi.org/10.1002/jsfa.6132 . .

TY  - JOUR
AU  - Žižić, Jovana B.
AU  - Vuković, Nenad L.
AU  - Jadranin, Milka
AU  - Anđelković, Boban D.
AU  - Tešević, Vele
AU  - Kacaniova, Miroslava M.
AU  - Sukdolak, Slobodan B.
AU  - Marković, Snežana D.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1387
AB  - BACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis (EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 mu gmg(-1)), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 mu gmL(-1). Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food and Agriculture
T1  - Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line
VL  - 93
IS  - 12
SP  - 3001
EP  - 3009
DO  - 10.1002/jsfa.6132
ER  - 

@article{
author = "Žižić, Jovana B. and Vuković, Nenad L. and Jadranin, Milka and Anđelković, Boban D. and Tešević, Vele and Kacaniova, Miroslava M. and Sukdolak, Slobodan B. and Marković, Snežana D.",
year = "2013",
abstract = "BACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis (EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 mu gmg(-1)), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 mu gmL(-1). Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food and Agriculture",
title = "Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line",
volume = "93",
number = "12",
pages = "3001-3009",
doi = "10.1002/jsfa.6132"
}

Žižić, J. B., Vuković, N. L., Jadranin, M., Anđelković, B. D., Tešević, V., Kacaniova, M. M., Sukdolak, S. B.,& Marković, S. D.. (2013). Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. in Journal of the Science of Food and Agriculture
Wiley, Hoboken., 93(12), 3001-3009.
https://doi.org/10.1002/jsfa.6132

Žižić JB, Vuković NL, Jadranin M, Anđelković BD, Tešević V, Kacaniova MM, Sukdolak SB, Marković SD. Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. in Journal of the Science of Food and Agriculture. 2013;93(12):3001-3009.
doi:10.1002/jsfa.6132 .

Žižić, Jovana B., Vuković, Nenad L., Jadranin, Milka, Anđelković, Boban D., Tešević, Vele, Kacaniova, Miroslava M., Sukdolak, Slobodan B., Marković, Snežana D., "Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line" in Journal of the Science of Food and Agriculture, 93, no. 12 (2013):3001-3009,
https://doi.org/10.1002/jsfa.6132 . .